Search

Your search keyword '"Simons, Estelle"' showing total 78 results
Start Over Author "Simons, Estelle"
78 results on '"Simons, Estelle"'

5. Self-injectable epinephrine for first-aid management of anaphylaxis

Author

Sicherer, Scott H. and Simons, Estelle R.

Abstract

INTRODUCTION Anaphylaxis is an acute, life-threatening reaction, usually mediated by an immunologic mechanism involving immunoglobulin E, that results in sudden systemic release of mast-cell and basophil mediators such as histamine [...], Anaphylaxis is a severe, potentially fatal systemic allergic reaction that is rapid in onset and may cause death. Epinephrine is the primary medical therapy, and it must be administered promptly. This clinical report focuses on practical issues concerning the administration of self-injectable epinephrine for first-aid treatment of anaphylaxis in the community. The recommended epinephrine dose for anaphylaxis in children, based primarily on anecdotal evidence, is 0.01 mg/kg, up to 0.30 mg. Intramuscular injection of epinephrine into the lateral thigh (vastus lateralis) is the preferred route for therapy in first-aid treatment. Epinephrine autoinjectors are currently available in only 2 fixed doses: 0.15 and 0.30 mg. On the basis of current, albeit limited, data, it seems reasonable to recommend autoinjectors with 0.15 mg of epinephrine for otherwise healthy young children who weigh 10 to 25 kg (22-55 lb) and autoinjectors with 0.30 mg of epinephrine for those who weigh approximately 25 kg (55 lb) or more; however, specific clinical circumstances must be considered in these decisions. This report also describes several quandaries in regard to management, including the selection of dose, indications for prescribing an autoinjector, and decisions regarding when to inject epinephrine. Effective care for individuals at risk of anaphylaxis requires a comprehensive management approach involving families, allergic children, schools, camps, and other youth organizations. Risk reduction entails confirmation of the trigger, discussion of avoidance of the relevant allergen, a written individualized emergency anaphylaxis action plan, and education of supervising adults with regard to recognition and treatment of anaphylaxis.

Published
2007

13. Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report

Author

Boyce, Joshua A., Assa', Amal, Burks, Wesley A., Jones, Stacie M., Sampson, Hugh A., Wood, Robert A., Plaut, Marshall, Cooper, Susan F., Fenton, Matthew J., Arshad, Hasan S., Bahna, Sami L., Beck, Lisa A., Byrd-Bredbenner, Carol, Camargo, Carlos A., Jr, Eichenfield, Lawrence, Furuta, Glenn T., Hanifin, Jon M., Jones, Carol, Kraft, Monica, Levy, Bruce D., Lieberman, Phil, Luccioli, Stefano, McCall, Kathleen M., Schneider, Lynda C., Simon, Ronald A., Simons, Estelle F. R., Teach, Stephen J., Yawn, Barbara P., and Schwaninger, Julie M.

Published
2011
Full Text
View/download PDF

14. Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report

Author

Boyce, Joshua A, Assaʼad, Amal, Burks, Wesley A, Jones, Stacie M, Sampson, Hugh A, Wood, Robert A, Plaut, Marshall, Cooper, Susan F, Fenton, Matthew J, Arshad, Hasan S, Bahna, Sami L, Beck, Lisa A, Byrd-Bredbenner, Carol, Camargo, Carlos A, Jr., Eichenfield, Lawrence, Furuta, Glenn T, Hanifin, Jon M, Jones, Carol, Kraft, Monica, Levy, Bruce D, Lieberman, Phil, Luccioli, Stefano, McCall, Kathleen M, Schneider, Lynda C, Simon, Ronald A, Simons, Estelle R. F, Teach, Stephen J, Yawn, Barbara P, and Schwaninger, Julie M

Published
2010

27. Is diet partly responsible for differences in COVID-19 death rates between and within countries?

Author

Bousquet, Jean, Anto, Josep M., Iaccarino, Guido, Czarlewski, Wienczyslawa, Haahtela, Tari, Anto, Aram, Akdis, Cezmi, Blain, Hubert, Canonica, G. Walter, Cardona, Victoria, Cruz, Alvaro A., Illario, Maddalena, Ivancevich, Juan Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Larenas-linnemann, Désirée, Mullol, Joaquim, Papadopoulos, Nikos G., Pfaar, Oliver, Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Zuberbier, Torsten, Latiff, Amir, Abdullah, Baharudin, Aberer, Werner, Abusada, Nancy, Adcock, Ian, Afani, Alejandro, Agache, Ioana, Aggelidis, Xenofon, Agustin, Jenifer, Akdis, Mübeccel, Al-Ahmad, Mona, Bassam, Abou Al Zahab, Aldrey-Palacios, Oscar, Cuesta, Emilio Alvarez, Alzaabi, Ashraf, Amad, Salma, Ambrocio, Gene, Annesi-Maesano, Isabella, Ansotegui, Ignacio, Anto, Josep, Arshad, Hasan, Artesani, Maria Cristina, Asayag, Estrella, Avolio, Francesca, Azhari, Khuzama, Baiardini, Ilaria, Bajrović, Nissera, Bakakos, Petros, Mongono, Sergio Bakeyala, Balotro-Torres, Christine, Barba, Sergio, Barbara, Cristina, Barbosa, Elsa, Barreto, Bruno, Bartra, Joan, Bateman, Eric D., Battur, Lkhagvaa, Bedbrook, Anna, Barajas, Martín Bedolla, Beghé, Bianca, Bel, Elizabeth, Kheder, Ali Ben, Benson, Mikael, Berghea, Camelia, Bergmann, Karl Christian, Bernstein, David, Bewick, Mike, Bialek, Slawomir, Białoszewski, Artur, Bieber, Thomas, Billo, Nils, Bilo, Maria Beatrice, Bindslev-Jensen, Carsten, Bjermer, Leif, Marciniak, Malgorzata Bochenska, Bond, Christine, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Botskariova, Sofia, Bouchard, Jacques, Boulet, Louis Philippe, Bourret, Rodolphe, Bousquet, Philippe, Braido, Fulvio, Briggs, Andrew, Brightling, Christopher, Brozek, Jan, Buhl, Roland, Bumbacea, Roxana, Cabañas, María Teresa Burguete, Bush, Andrew, Busse, William W., Buters, Jeroen, Caballero-Fonseca, Fernan, Calderon, Moïses A., Calvo, Mario, Camargos, Paulo, Camuzat, Thierry, Cano, Antonio, Capriles-Hulett, Arnaldo, Caraballo, Luis, Cardona, Vicky, Carlsen, Kai Hakon, Caro, Jorge, Carreon-Asun-cion, Fredelita, Carriazo, Ana Maria, Casale, Thomas, Castor, Mary Ann, Castro, Elizabeth, Cecchi, Lorenzo, Sarabia, Alfonso Cepeda, Chandrasekharan, Ramanathan, Chang, Yoon Suk, Chato-Andeza, Victoria, Chatzi, Lida, Chatzidaki, Christina, Chavannes, Niels H., Chen, Yuzhi, Cheng, Lei, Chivato, Tomas, Chkhartishvili, Ekaterine, Christoff, George, Chrystyn, Henry, Chu, Derek K., Chua, Antonio, Chuchalin, Alexander, Chung, Kian Fan, Cicerán, Alberto, Cingi, Cemal, Ciprandi, Giorgio, Cirule, Ieva, Coelho, Ana Carla, Constantinidis, Jannis, de Sousa, Jaime Correia, Costa, Elisio, Costa, David, Domínguez, María Del Carmen Costa, Coste, André, Cox, Linda, Cullen, John, Custovic, Adnan, Cvetkovski, Biljana, D’amato, Gennaro, Silva, Jane da, Dahl, Ronald, Dahlen, Sven Erik, Daniilidis, Vasilis, Nahhas, Louei Darjazini, Darsow, Ulf, Blay, Frédéric de, Guia, Eloisa De, Santos, Chato de los, Keenoy, Esteban De Manuel, Vries, Govert De, Deleanu, Diana, Demoly, Pascal, Denburg, Judah, Devillier, Philippe, Didier, Alain, Dimou, Maria, Dinh-Xuan, Anh Tuan, Djukanovic, Ratko, Dokic, Dejan, Domínguez Silva, Margarita Gabriela, Douagui, Habib, Douladiris, Nikolaos, Doulaptsi, Maria, Dray, Gérard, Dubakiene, Ruta, Durham, Stephen, Dykewicz, Mark, Ebo, Didier, Edelbaher, Natalija, Eklund, Patrik, El-Gamal, Yehia, El-Sayed, Zeinab A., El-Sayed, Shereen S., El-Seify, Magda, Emuzyte, Regina, Enecilla, Lourdes, Espinoza, Heidilita, Guillermo, Jesús, Contreras, Espinoza, Farrell, John, Fernandez, Lenora, Wagner, Antje Fink, Fiocchi, Alessandro, Fokkens, Wytske J., Fontaine, Jean François, Forastiere, Francesco, Pèrez, Jose Miguel Fuentes, Gaerlan–resureccion, Emily, Gaga, Mina, Romero, José Luis Gálvez, Gamkrelidze, Amiran, Garcia, Alexis, Cobas, Cecilia Yvonne García, García Cruz, María de la Luz Hortensia, Gayraud, Jacques, Gemicioglu, Bilun, Genova, Sonya, Gereda, José, Wijk, Roy Gerth van, Gomez, Maximiliano, Diaz, Sandra González, Gotua, Maia, Grigoreas, Christos, Grisle, Ineta, Guidacci, Marta, Guldemond, Nick, Gutter, Zdenek, Guzmán, Antonieta, Halloum, Ramsa, Hamelmann, Eckard, Hammadi, Suleiman, Harvey, Richard, Heinrich, Joachim, Hejjaoui, Adnan, Hellquist-Dahl, Birthe, Velázquez, Luiana Hernández, Hew, Mark, Hossny, Elham, Howarth, Peter, Hrubiško, Martin, Villalobos, Yunuen Rocío Huerta, Humbert, Marc, Hyland, Michael, Ibrahim, Moustafa, Ilyina, Natalia, Irani, Carla, Ispayeva, Zhanat, Jares, Edgardo, Jarvis, Deborah, Jassem, Ewa, Jenko, Klemen, Uscanga, Rubén Darío Jiméneracruz, Johnston, Sebastian, Joos, Guy, Jošt, Maja, Julge, Kaja, Jung, Ki Suck, Just, Jocelyne, Kaidashev, Igor, Kalayci, Omer, Kalyoncu, Fuat, Kapsali, Jeni, Kardas, Przemyslaw, Karjalainen, Jussi, Kasala, Carmela A., Katotomichelakis, Michael, Kazi, Bennoor, Keil, Thomas, Keith, Paul, Khaitov, Musa, Khaltaev, Nikolai, Kim, You Young, Kleine-Tebbe, Jorg, Koffi N’Goran, Bernard, Kompoti, Evangelia, Kopač, Peter, Koppelman, Gerard, Jeverica, Anja Koren, Košnik, Mitja, Kostov, Kosta V., Kowalski, Marek L., Kralimarkova, Tanya, Vrščaj, Karmen Kramer, Kraxner, Helga, Kreft, Samo, Kritikos, Vicky, Kudlay, Dmitry, Kull, Inger, Kupczyk, Maciej, Kvedariene, Violeta, Kyriakakou, Marialena, Lalek, Nika, Lane, Stephen, Larenas-Linnemann, Désiree, Lau, Susanne, Lavrut, Jorge, Le, Lan, Lessa, Marcus, Levin, Michael, Li, Jing, Lieberman, Philip, Liotta, Giuseppe, Lipworth, Brian, Liu, Xuandao, Lobo, Rommel, Lodrup Carlsen, Karin C., Lombardi, Carlo, Louis, Renaud, Loukidis, Stelios, Lourenço, Olga, Luna Pech, Jorge A., Madjar, Bojan, Magnan, Antoine, Mahboub, Bassam, Mair, Alpana, Mais, Yassin, van der Zee, Anke Hilse Maitland, Makela, Mika, Makris, Michael, Malling, Hans Jorgen, Mandajieva, Mariana, Manning, Patrick, Manousakis, Manolis, Maragoudakis, Pavlos, Marshall, Gailen, Martins, Pedro, Reza Masjedi, Mohammad, Máspero, Jorge F., Campos, Juan José Matta, Maurer, Marcus, Mavale-Manuel, Sandra, Meço, Cem, Melén, Erik, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Menzies-Gow, Andrew, Merk, Hans, Michel, Jean Pierre, Miculinic, Neven, Midão, Luís, Mihaltan, Florin, Mikael, Kuitunen, Mikos, Nikolaos, Milenkovic, Branislava, Mitsias, Dimitrios, Moalla, Bassem, Moda, Giuliana, Martínez, María Dolores Mogica, Mohammad, Yousser, Moin, Mostafa, Molimard, Mathieu, Momas, Isabelle, Monaco, Alessandro, Montefort, Steve, Mora, Dory, Morais-Almeida, Mario, Mösges, Ralph, Mostafa, Badr Eldin, Münter, Lars, Muraro, Antonella, Murray, Ruth, Mustakov, Tihomir, Naclerio, Robert, Nadif, Rachel, Nakonechna, Alla, Namazova-Baranova, Leyla, Navarro-Locsin, Gretchen, Neffen, Hugo, Nekam, Kristof, Neou, Angelos, Nicod, Laurent, Niederberger-Leppin, Verena, Niedoszytko, Marek, Nieto, Antonio, Novellino, Ettore, Nunes, Elizabete, Nyembue, Dieudonné, O’hehir, Robyn, Odjakova, Cvetanka, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimi, Oliver, Brian, Onorato, Gabrielle L., Orru, Maria Pia, Ouédraogo, Solange, Ouoba, Kampadilemba, Paggiaro, Pier Luigi, Pagkalos, Aris, Palaniappan, S. P., Pali-Schöll, Isabella, Palkonen, Susanna, Palmer, Stephen, Bunu, Carmen Panaitescu, Panzner, Petr, Papanikolaou, Vasilis, Papi, Alberto, Paralchev, Bojidar, Paraskevopoulos, Giannis, Park, Hae Sim, Passalacqua, Giovanni, Patella, Vincenzo, Pavord, Ian, Pawankar, Ruby, Pedersen, Soren, Peleve, Susete, Pereira, Ana, Pérez, Tamara, Pham-Thi, Nhân, Pigearias, Bernard, Pin, Isabelle, Piskou, Konstantina, Pitsios, Constantinos, Pitsios, Kostas, Plavec, Davor, Poethig, Dagmar, Pohl, Wolfgang, Susic, Antonija Poplas, Popov, Todor A., Portejoie, Fabienne, Potter, Paul, Poulsen, Lars, Prados-Torres, Alexandra, Prarros, Fotis, Price, David, Prokopakis, Emmanuel, Puy, Robert, Rabe, Klaus, Raciborski, Filip, Ramos, Josephine, Recto, Marysia T., Reda, Shereen M., Regateiro, Frederico, Reider, Norbert, Reitsma, Sietze, Repka-Ramirez, Susana, Rimmer, Janet, Yeverino, Daniela Rivero, Rizzo, José Angelo, Robalo-Cordeiro, Carlos, Roberts, Graham, Roche, Nicolas, González, Mónica Rodríguez, Zagal, Eréndira Rodríguez, Rolland, Christine, Roller-Wirns-berger, Regina, Rodriguez, Miguel Roman, Romano, Antonino, Rombaux, Philippe, Romualdez, Joel, Rosado-Pinto, Jose, Rosario, Nelson, Rosenwasser, Lanny, Rottem, Menachem, Rouadi, Philip, Rovina, Nikoleta, Sinur, Irma Rozman, Ruiz, Mauricio, Segura, Lucy Tania Ruiz, Ryan, Dermot, Sagara, Hironori, Sakai, Daiki, Sakurai, Daiju, Saleh, Wafaa, Salimaki, Johanna, Salina, Husain, Samitas, Konstanti Nos, Coronel, María Guadalupe Sánchez, Sanchez-Borges, Mario, Sanchez-Lopez, Jaime, Sarafoleanu, Codrut, Serpa, Faradiba Sarquis, Sastre-Dominguez, Joaquin, Scadding, Glenis, Scheire, Sophie, Schmid-Grendelmeier, Peter, Schuhl, Juan Francisco, Schunemann, Holger, Schvalbová, Maria, Scichilone, Nicola, Sepúlveda, Cecilia, Serrano, Elie, Sheikh, Aziz, Shields, Mike, Shishkov, Vasil, Siafakas, Nikos, Simeonov, Alexander, Simons, Estelle F., Sisul, Juan Carlos, Sitkauskiene, Brigita, Skrindo, Ingelbjorg, Košak, Tanja Soklič, Solé, Dirceu, Sooronbaev, Talant, Soto-Martinez, Manuel, Sova, Milan, Spertini, François, Spranger, Otto, Stamataki, Sofia, Stefanaki, Lina, Stellato, Cristiana, Stelmach, Rafael, Sterk, Peter, Strandberg, Timo, Stute, Petra, Subramaniam, Abirami, Suppli Ulrik, Charlotte, Sutherland, Michael, Sylvestre, Silvia, Syrigou, Aikaterini, Barata, Luis Taborda, Takovska, Nadejda, Tan, Rachel, Tan, Frances, Tan, Vincent, Tang, Ing Ping, Taniguchi, Masami, Tannert, Line, Tattersall, Jessica, Teixeira, Maria Do Ceu, Thijs, Carel, Thomas, Mike, To, Teresa, Todo-Bom, Ana Maria, Togias, Alkis, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Toskala, Elina, Triggiani, Massimo, Triller, Nadja, Triller, Katja, Tsiligianni, Ioanna, Ulmeanu, Ruxandra, Urbancic, Jure, Pereira, Marilyn Urrutia, Vachova, Martina, Valdés, Felipe, Valenta, Rudolf, Rostan, Marylin Valentin, Valero, Antonio, Vallianatou, Mina, Valovirta, Erkka, Eerd, Michiel Van, Ganse, Eric Van, Hage, Marianne van, Vandenplas, Olivier, Vasankari, Tuula, Vassileva, Dafina, Ventura, Teresa, Vera-Munoz, Cécilia, Vicheva, Dilyana, Vichyanond, Pakit, Vidgren, Petra, Viegi, Giovanni, Vogelmeier, Claus, Hertzen, Leena Von, Vontetsianos, Theodoros, Vourdas, Dimitris, Wagenmann, Martin, Walker, Samantha, Wallace, Dana, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Sian, Williams, Dennis, Wilson, Nicola, Woo, Kent, Wright, John, Wroczynski, Piotr, Xepapadaki, Paraskevi, Yakovliev, Plamen, Yamaguchi, Masao, Yan, Kwok, Yap, Yoke Yeow, Yawn, Barbara, Yiallouros, Panayiotis, Yoshihara, Shigemi, Young, Ian, Yusuf, Osman B., Zaidi, Asghar, Zaitoun, Fares, Zar, Heather, Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, Zubrinich, Celia, Bousquet, Jean, Anto, Josep M., Iaccarino, Guido, Czarlewski, Wienczyslawa, Haahtela, Tari, Anto, Aram, Akdis, Cezmi, Blain, Hubert, Canonica, G. Walter, Cardona, Victoria, Cruz, Alvaro A., Illario, Maddalena, Ivancevich, Juan Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Larenas-linnemann, Désirée, Mullol, Joaquim, Papadopoulos, Nikos G., Pfaar, Oliver, Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Zuberbier, Torsten, Latiff, Amir, Abdullah, Baharudin, Aberer, Werner, Abusada, Nancy, Adcock, Ian, Afani, Alejandro, Agache, Ioana, Aggelidis, Xenofon, Agustin, Jenifer, Akdis, Mübeccel, Al-Ahmad, Mona, Bassam, Abou Al Zahab, Aldrey-Palacios, Oscar, Cuesta, Emilio Alvarez, Alzaabi, Ashraf, Amad, Salma, Ambrocio, Gene, Annesi-Maesano, Isabella, Ansotegui, Ignacio, Anto, Josep, Arshad, Hasan, Artesani, Maria Cristina, Asayag, Estrella, Avolio, Francesca, Azhari, Khuzama, Baiardini, Ilaria, Bajrović, Nissera, Bakakos, Petros, Mongono, Sergio Bakeyala, Balotro-Torres, Christine, Barba, Sergio, Barbara, Cristina, Barbosa, Elsa, Barreto, Bruno, Bartra, Joan, Bateman, Eric D., Battur, Lkhagvaa, Bedbrook, Anna, Barajas, Martín Bedolla, Beghé, Bianca, Bel, Elizabeth, Kheder, Ali Ben, Benson, Mikael, Berghea, Camelia, Bergmann, Karl Christian, Bernstein, David, Bewick, Mike, Bialek, Slawomir, Białoszewski, Artur, Bieber, Thomas, Billo, Nils, Bilo, Maria Beatrice, Bindslev-Jensen, Carsten, Bjermer, Leif, Marciniak, Malgorzata Bochenska, Bond, Christine, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Botskariova, Sofia, Bouchard, Jacques, Boulet, Louis Philippe, Bourret, Rodolphe, Bousquet, Philippe, Braido, Fulvio, Briggs, Andrew, Brightling, Christopher, Brozek, Jan, Buhl, Roland, Bumbacea, Roxana, Cabañas, María Teresa Burguete, Bush, Andrew, Busse, William W., Buters, Jeroen, Caballero-Fonseca, Fernan, Calderon, Moïses A., Calvo, Mario, Camargos, Paulo, Camuzat, Thierry, Cano, Antonio, Capriles-Hulett, Arnaldo, Caraballo, Luis, Cardona, Vicky, Carlsen, Kai Hakon, Caro, Jorge, Carreon-Asun-cion, Fredelita, Carriazo, Ana Maria, Casale, Thomas, Castor, Mary Ann, Castro, Elizabeth, Cecchi, Lorenzo, Sarabia, Alfonso Cepeda, Chandrasekharan, Ramanathan, Chang, Yoon Suk, Chato-Andeza, Victoria, Chatzi, Lida, Chatzidaki, Christina, Chavannes, Niels H., Chen, Yuzhi, Cheng, Lei, Chivato, Tomas, Chkhartishvili, Ekaterine, Christoff, George, Chrystyn, Henry, Chu, Derek K., Chua, Antonio, Chuchalin, Alexander, Chung, Kian Fan, Cicerán, Alberto, Cingi, Cemal, Ciprandi, Giorgio, Cirule, Ieva, Coelho, Ana Carla, Constantinidis, Jannis, de Sousa, Jaime Correia, Costa, Elisio, Costa, David, Domínguez, María Del Carmen Costa, Coste, André, Cox, Linda, Cullen, John, Custovic, Adnan, Cvetkovski, Biljana, D’amato, Gennaro, Silva, Jane da, Dahl, Ronald, Dahlen, Sven Erik, Daniilidis, Vasilis, Nahhas, Louei Darjazini, Darsow, Ulf, Blay, Frédéric de, Guia, Eloisa De, Santos, Chato de los, Keenoy, Esteban De Manuel, Vries, Govert De, Deleanu, Diana, Demoly, Pascal, Denburg, Judah, Devillier, Philippe, Didier, Alain, Dimou, Maria, Dinh-Xuan, Anh Tuan, Djukanovic, Ratko, Dokic, Dejan, Domínguez Silva, Margarita Gabriela, Douagui, Habib, Douladiris, Nikolaos, Doulaptsi, Maria, Dray, Gérard, Dubakiene, Ruta, Durham, Stephen, Dykewicz, Mark, Ebo, Didier, Edelbaher, Natalija, Eklund, Patrik, El-Gamal, Yehia, El-Sayed, Zeinab A., El-Sayed, Shereen S., El-Seify, Magda, Emuzyte, Regina, Enecilla, Lourdes, Espinoza, Heidilita, Guillermo, Jesús, Contreras, Espinoza, Farrell, John, Fernandez, Lenora, Wagner, Antje Fink, Fiocchi, Alessandro, Fokkens, Wytske J., Fontaine, Jean François, Forastiere, Francesco, Pèrez, Jose Miguel Fuentes, Gaerlan–resureccion, Emily, Gaga, Mina, Romero, José Luis Gálvez, Gamkrelidze, Amiran, Garcia, Alexis, Cobas, Cecilia Yvonne García, García Cruz, María de la Luz Hortensia, Gayraud, Jacques, Gemicioglu, Bilun, Genova, Sonya, Gereda, José, Wijk, Roy Gerth van, Gomez, Maximiliano, Diaz, Sandra González, Gotua, Maia, Grigoreas, Christos, Grisle, Ineta, Guidacci, Marta, Guldemond, Nick, Gutter, Zdenek, Guzmán, Antonieta, Halloum, Ramsa, Hamelmann, Eckard, Hammadi, Suleiman, Harvey, Richard, Heinrich, Joachim, Hejjaoui, Adnan, Hellquist-Dahl, Birthe, Velázquez, Luiana Hernández, Hew, Mark, Hossny, Elham, Howarth, Peter, Hrubiško, Martin, Villalobos, Yunuen Rocío Huerta, Humbert, Marc, Hyland, Michael, Ibrahim, Moustafa, Ilyina, Natalia, Irani, Carla, Ispayeva, Zhanat, Jares, Edgardo, Jarvis, Deborah, Jassem, Ewa, Jenko, Klemen, Uscanga, Rubén Darío Jiméneracruz, Johnston, Sebastian, Joos, Guy, Jošt, Maja, Julge, Kaja, Jung, Ki Suck, Just, Jocelyne, Kaidashev, Igor, Kalayci, Omer, Kalyoncu, Fuat, Kapsali, Jeni, Kardas, Przemyslaw, Karjalainen, Jussi, Kasala, Carmela A., Katotomichelakis, Michael, Kazi, Bennoor, Keil, Thomas, Keith, Paul, Khaitov, Musa, Khaltaev, Nikolai, Kim, You Young, Kleine-Tebbe, Jorg, Koffi N’Goran, Bernard, Kompoti, Evangelia, Kopač, Peter, Koppelman, Gerard, Jeverica, Anja Koren, Košnik, Mitja, Kostov, Kosta V., Kowalski, Marek L., Kralimarkova, Tanya, Vrščaj, Karmen Kramer, Kraxner, Helga, Kreft, Samo, Kritikos, Vicky, Kudlay, Dmitry, Kull, Inger, Kupczyk, Maciej, Kvedariene, Violeta, Kyriakakou, Marialena, Lalek, Nika, Lane, Stephen, Larenas-Linnemann, Désiree, Lau, Susanne, Lavrut, Jorge, Le, Lan, Lessa, Marcus, Levin, Michael, Li, Jing, Lieberman, Philip, Liotta, Giuseppe, Lipworth, Brian, Liu, Xuandao, Lobo, Rommel, Lodrup Carlsen, Karin C., Lombardi, Carlo, Louis, Renaud, Loukidis, Stelios, Lourenço, Olga, Luna Pech, Jorge A., Madjar, Bojan, Magnan, Antoine, Mahboub, Bassam, Mair, Alpana, Mais, Yassin, van der Zee, Anke Hilse Maitland, Makela, Mika, Makris, Michael, Malling, Hans Jorgen, Mandajieva, Mariana, Manning, Patrick, Manousakis, Manolis, Maragoudakis, Pavlos, Marshall, Gailen, Martins, Pedro, Reza Masjedi, Mohammad, Máspero, Jorge F., Campos, Juan José Matta, Maurer, Marcus, Mavale-Manuel, Sandra, Meço, Cem, Melén, Erik, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Menzies-Gow, Andrew, Merk, Hans, Michel, Jean Pierre, Miculinic, Neven, Midão, Luís, Mihaltan, Florin, Mikael, Kuitunen, Mikos, Nikolaos, Milenkovic, Branislava, Mitsias, Dimitrios, Moalla, Bassem, Moda, Giuliana, Martínez, María Dolores Mogica, Mohammad, Yousser, Moin, Mostafa, Molimard, Mathieu, Momas, Isabelle, Monaco, Alessandro, Montefort, Steve, Mora, Dory, Morais-Almeida, Mario, Mösges, Ralph, Mostafa, Badr Eldin, Münter, Lars, Muraro, Antonella, Murray, Ruth, Mustakov, Tihomir, Naclerio, Robert, Nadif, Rachel, Nakonechna, Alla, Namazova-Baranova, Leyla, Navarro-Locsin, Gretchen, Neffen, Hugo, Nekam, Kristof, Neou, Angelos, Nicod, Laurent, Niederberger-Leppin, Verena, Niedoszytko, Marek, Nieto, Antonio, Novellino, Ettore, Nunes, Elizabete, Nyembue, Dieudonné, O’hehir, Robyn, Odjakova, Cvetanka, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimi, Oliver, Brian, Onorato, Gabrielle L., Orru, Maria Pia, Ouédraogo, Solange, Ouoba, Kampadilemba, Paggiaro, Pier Luigi, Pagkalos, Aris, Palaniappan, S. P., Pali-Schöll, Isabella, Palkonen, Susanna, Palmer, Stephen, Bunu, Carmen Panaitescu, Panzner, Petr, Papanikolaou, Vasilis, Papi, Alberto, Paralchev, Bojidar, Paraskevopoulos, Giannis, Park, Hae Sim, Passalacqua, Giovanni, Patella, Vincenzo, Pavord, Ian, Pawankar, Ruby, Pedersen, Soren, Peleve, Susete, Pereira, Ana, Pérez, Tamara, Pham-Thi, Nhân, Pigearias, Bernard, Pin, Isabelle, Piskou, Konstantina, Pitsios, Constantinos, Pitsios, Kostas, Plavec, Davor, Poethig, Dagmar, Pohl, Wolfgang, Susic, Antonija Poplas, Popov, Todor A., Portejoie, Fabienne, Potter, Paul, Poulsen, Lars, Prados-Torres, Alexandra, Prarros, Fotis, Price, David, Prokopakis, Emmanuel, Puy, Robert, Rabe, Klaus, Raciborski, Filip, Ramos, Josephine, Recto, Marysia T., Reda, Shereen M., Regateiro, Frederico, Reider, Norbert, Reitsma, Sietze, Repka-Ramirez, Susana, Rimmer, Janet, Yeverino, Daniela Rivero, Rizzo, José Angelo, Robalo-Cordeiro, Carlos, Roberts, Graham, Roche, Nicolas, González, Mónica Rodríguez, Zagal, Eréndira Rodríguez, Rolland, Christine, Roller-Wirns-berger, Regina, Rodriguez, Miguel Roman, Romano, Antonino, Rombaux, Philippe, Romualdez, Joel, Rosado-Pinto, Jose, Rosario, Nelson, Rosenwasser, Lanny, Rottem, Menachem, Rouadi, Philip, Rovina, Nikoleta, Sinur, Irma Rozman, Ruiz, Mauricio, Segura, Lucy Tania Ruiz, Ryan, Dermot, Sagara, Hironori, Sakai, Daiki, Sakurai, Daiju, Saleh, Wafaa, Salimaki, Johanna, Salina, Husain, Samitas, Konstanti Nos, Coronel, María Guadalupe Sánchez, Sanchez-Borges, Mario, Sanchez-Lopez, Jaime, Sarafoleanu, Codrut, Serpa, Faradiba Sarquis, Sastre-Dominguez, Joaquin, Scadding, Glenis, Scheire, Sophie, Schmid-Grendelmeier, Peter, Schuhl, Juan Francisco, Schunemann, Holger, Schvalbová, Maria, Scichilone, Nicola, Sepúlveda, Cecilia, Serrano, Elie, Sheikh, Aziz, Shields, Mike, Shishkov, Vasil, Siafakas, Nikos, Simeonov, Alexander, Simons, Estelle F., Sisul, Juan Carlos, Sitkauskiene, Brigita, Skrindo, Ingelbjorg, Košak, Tanja Soklič, Solé, Dirceu, Sooronbaev, Talant, Soto-Martinez, Manuel, Sova, Milan, Spertini, François, Spranger, Otto, Stamataki, Sofia, Stefanaki, Lina, Stellato, Cristiana, Stelmach, Rafael, Sterk, Peter, Strandberg, Timo, Stute, Petra, Subramaniam, Abirami, Suppli Ulrik, Charlotte, Sutherland, Michael, Sylvestre, Silvia, Syrigou, Aikaterini, Barata, Luis Taborda, Takovska, Nadejda, Tan, Rachel, Tan, Frances, Tan, Vincent, Tang, Ing Ping, Taniguchi, Masami, Tannert, Line, Tattersall, Jessica, Teixeira, Maria Do Ceu, Thijs, Carel, Thomas, Mike, To, Teresa, Todo-Bom, Ana Maria, Togias, Alkis, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Toskala, Elina, Triggiani, Massimo, Triller, Nadja, Triller, Katja, Tsiligianni, Ioanna, Ulmeanu, Ruxandra, Urbancic, Jure, Pereira, Marilyn Urrutia, Vachova, Martina, Valdés, Felipe, Valenta, Rudolf, Rostan, Marylin Valentin, Valero, Antonio, Vallianatou, Mina, Valovirta, Erkka, Eerd, Michiel Van, Ganse, Eric Van, Hage, Marianne van, Vandenplas, Olivier, Vasankari, Tuula, Vassileva, Dafina, Ventura, Teresa, Vera-Munoz, Cécilia, Vicheva, Dilyana, Vichyanond, Pakit, Vidgren, Petra, Viegi, Giovanni, Vogelmeier, Claus, Hertzen, Leena Von, Vontetsianos, Theodoros, Vourdas, Dimitris, Wagenmann, Martin, Walker, Samantha, Wallace, Dana, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Sian, Williams, Dennis, Wilson, Nicola, Woo, Kent, Wright, John, Wroczynski, Piotr, Xepapadaki, Paraskevi, Yakovliev, Plamen, Yamaguchi, Masao, Yan, Kwok, Yap, Yoke Yeow, Yawn, Barbara, Yiallouros, Panayiotis, Yoshihara, Shigemi, Young, Ian, Yusuf, Osman B., Zaidi, Asghar, Zaitoun, Fares, Zar, Heather, Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, and Zubrinich, Celia

Abstract

Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on COVID-19 focus on the differences among countries, but little attention has been given to regional differences and diet. The low-death rate European countries (e.g. Austria, Baltic States, Czech Republic, Finland, Norway, Poland, Slovakia) have used different quarantine and/or confinement times and methods and none have performed as many early tests as Germany. Among other factors that may be significant are the dietary habits. It seems that some foods largely used in these countries may reduce angiotensin-converting enzyme activity or are anti-oxidants. Among the many possible areas of research, it might be important to understand diet and angiotensin-converting enzyme-2 (ACE2) levels in populations with different COVID-19 death rates since dietary interventions may be of great benefit.

Published
2020

43. Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study

Author

Haselkorn, Tmirah, Fish, James E., Zeiger, Robert S., Szefler, Stanley J., Miller, Dave P., Chipps, Bradley E., Simons, Estelle F. R., Weiss, Scott T., Wenzel, Sally E., Borish, Larry, and Bleecker, Eugene R.

Published
2009

44. WAO International Scientific Conference (WISC 2016) Abstracts

Author

Bao, Jun, Wang, Yi-Hui, Liu, Quan-Hua, Bao, Yi-Xiao, Azouz, Nurit, Caldwell, Julie, Ray, Leanne, Rochman, Mark, Mingler, Melissa, Eilerman, Matthew, Wen, Ting, Myers, Jocelyn Biagini, Hershey, Gurjit Khurana, Kottyan, Leah, Martin, Lisa, Marc, Rothenberg, Gonzalez-Uribe, Victor, Del Rio-Chivardi, Jaime, Del Rio-Navarro, Blanca, Lou, Hongfei, Ma, Siyuan, Zhao, Yan, Cao, Feifei, He, Fei, Liu, Zhongyan, Wang, Chengshuo, Bachert, Claus, Zhang, Luo, Abrams, Elissa, Becker, Allan, Kandhare, Amit, Bodhankar, Subhash, Grossman, Nicole, Doros, Gheorghe, Laden, Francine, Fuhlbrigge, Anne, Wechsler, Michael, Pace, Wilson, Yawn, Barbara, Israel, Elliot, Lee, Junehyuk, Adler, Frederick, Kim, Peter, Huang, Yung Feng, Chen, Ying Yao, Pan, Chiun Yen, Lee, Herng Sheng, Khalemsky, Michael, Schwartz, David G., Kolkhir, Pavel, Pogorelov, Dmitry, Kochergin, Nikolay, Komarow, Hirsh, Young, Michael, Eisch, Robin, Scott, Linda, Metcalfe, Dean, Singer, Alexander, Wakeman, Andrew, Gerstner, Thomas, Song, Woo-Jung, Shim, Ji-Su, Won, Ha-Kyeong, Kang, Sung-Yoon, Sohn, Kyoung-Hee, Kim, Byung-Keun, Jo, Eun-Jung, Kim, Min-Hye, Kim, Sang-Heon, Park, Heung-Woo, Kim, Sun-Sin, Chang, Yoon-Seok, Morice, Alyn H., Lee, Byung-Jae, Cho, Sang-Heon, Min, Kyung-Up, Boscolo, Maria Assunta, Brivio, Giulio, Bosisio, Sergio, Manzocchi, Nicoletta, Pulixi, Edoardo, Grignani, Giulia, D’Andrea, Eloisia, Ricci, Massimo, Passini, Elena, Italia, Maurizio, Urrutia-Pereira, Marilyn, Fagundes, Stefani, Oliano, Vinicius Jardim, Solé, Dirceu, Benzaquen, Sadia, Aragaki, Alejandro, Balestra, Ricardo, Harden, Dawn, Caudell-Stamper, Danielle, Glady, Gilbert, Holbreich, Mark, Lyakhovska, Nataliya, Kaidashev, Igor, Bystron, Jaromir, Hutyrova, Beata, Balakirski, Galina, Vanstreels, Luk, Wurpts, Gerda, Merk, Hans F., Baron, Jens Malte, Plange, Johanna, Rihs, Hans-Peter, Raulf, Monika, Roeseler, Stefani, Tolcachier, Alberto, Chamorro, Armando, Otero, Ruth, Brooks, Joel, Hess, Michael, Benz, Jared, MacDonald, Joseph, Chatha, Usma, Lent, Dale, Köse, Şükran, Tatar, Bengü Gireniz, Akkoçlu, Gülgün, Çukurova, İbrahim, Ödemiş, İlker, Toker, Ayşin Kılınç, Hasssan, Abdullahi, Gobir, Abdulrazaq Abdullahi, Kim, Cheol-Woo, Choi, Young Hwa, Lee, Jeong Hye, Cho, Rae Jeong, Nam, Yu Ran, Nam, Joo Hyun, Kim, Woo Kyung, Filipovic, Ivana, Zivkovic, Zorica, Filipovic, Djordje, Shik, Dana, Smith, Andrew, Hsi, Wang Yui, Friedman, Stuart, Gizaw, Yonatan, Bakhda, Rima, Mohammed, Kumail, Wasserman, Richard, Hague, Angela, Pence, Deanna, Rolen, Joanna, Sugerman, Robert, Silvers, Stacy, Kamili, Qurat, Knauer, Nadezhda, Zazernyi, Alexandr, Blinova, Elena, Demina, Daria, Kozlov, Vladimir, Agrawal, Komal, Kale, Sagar, Arora, Naveen, Vasilkova, Volha, Mokhort, Tatiana, Silvers, William, Eisenberg, Rachel, Mehta, Rushita, Rubinstein, Arye, Aston, Antony, Turner, Paul, Ruiz-Garcia, Monica, Boyle, Robert, Brown, Simon, Schejter, Yael Dinur, Ovadia, Adi, Kim, Vy, Reid, Brenda, Roifman, Chaim, Rosenfield, Lana, Avilla, Ernie, Harada, Laurie, Allen, Marilyn, Waserman, Susan, Yoon, Ho Joo, Koo, Gun Woo, Chang, Suk-Il, Yoon, Hye-Ran, Park, Dong Won, Park, Tai Sun, Moon, Ji-Yong, Kim, Tae Hyung, Sohn, Jang Won, Shin, Dong Ho, Jorjoliani, Tsici, Jorjoliani, Lia, Adamia, Nino, katamadze, Nona, Ramachandra, Deepika, Jorjoliani, Liana, Karseladze, Rusudan, Saginadze, Lali, Chkuaseli, Natalia, Dolgova, Anna, Stukolova, Olga, Sudina, Anna, Cherkashina, Anna, Shipulin, German, Rosenthal, Richard, Howe, Harvey, Knause, Paul, Greemberg, Rony, De Bruycker, Jean Jacques, Fernandez, Isabel, Le Deist, Françoise, Haddad, Elie, Rha, Yeong Ho, Lee, Kyung Suk, Choi, Sun Hee, Tam, Herman, Simons, Estelle, Simons, Elinor, Golebiowska-Wawrzyniak, Maria, Markiewicz, Katarzyna, Faitelson, Yoram, Stein, Miguel, Mandelberg, Avigdor, Dalal, Ilan, Levin, Michael, Hobane, Lelani, Basera, Wisdom, Botha, Maresa, Gray, Claudia, Zar, Heather, Kjaeva, Biserka Jovkovska, Arsovski, Zoran, Grivcheva-Panovska, Vesna, Odebode, Adeyinka, Adekunle, Adedotun, Adeonipekun, Peter, Farombi, Ebenezer, Camacho-Ordoñez, Nadezhda, Martinez-Vázquez, Alejandrina Josefina, García-Cruz, María de la Luz H., Tan, Qi, Min, Rui, Dai, Guan-qun, Xie, Wei-Ping, Mao, Huang, Wang, Hong, Yadav, Rakesh, Singh, Sneha, Yadav, Divya, Khaleva, Ekaterina, Bahnson, Henry T., Franz, Amber, Garvey, Lene Heise, Jay, Nicola, Haque, Rubaiyat, Fox, Adam, Lack, Gideon, du Toit, George, Radic, Snezana, Milenkovic, Branislava, Neskovic, Ana, Danojevic, Ljiljana, Nachshon, Liat, Goldberg, Michael, Levy, Michael, Katz, Yitzhak, Elizur, Arnon, Rosario, Cristine, Kasper, Juliana, Chong-Neto, Herbeto, Riedi, Carlos, Rosario, Nelson, Levy, Michael B., Har-Even, Ronly, Carmel, Mor, Goldberg, Michael R., Kherkheulidze, Maia, Kavlashvili, Nani, Kandelaki, Eka, Adamai, Nino, Ubiria, Irma, Burke, Andrea, Kastner, Monika, Zheleva, Denica, Darlenski, Razvigor, Bozinakis, Konstantinos, Kriebardis, Anastasios, Styliara, Sofia, Karastathi, Aikaterini, Farmakas, Nikolaos, Ribeiro, Maria Luiza Kraft Kohler, Barcellos, Ana Carolina, Silva, Hannah Gabriele Ferreira, Carletto, Luís Henrique Mattei, Bet, Marcela Carolina, Rossetto, Nathalia Zorze, Rosario, Nelson Augusto, Chong-Neto, Herberto Jose, Valença, Fernanda, Novaes, Marina, Gomes, Mariana, Seifert, Carla, Neto, Alfredo, Loyola, Flavia, Rios, José, Silva, Tatiana, Neves, Aline, Abadoglu, Oznur, Gemicioglu, Bilun, Bayram, Hasan, Cimrin, Arif, Akyildiz, Levent, Cilli, Aykut, Gunen, Hakan, Ozlu, Tevfik, Suerdem, Mecit, Uzaslan, Esra, Misirligil, Zeynep, Ristic-Stojanovic, Snezana, Milicevic, A., Milenkovic, A., Cvejic, Jelena, Jankovic, Jelena, Dimic-Janjic, Sanja, Djurdjevic, Natasa, Barzylovych, Vladyslava, Umanets, Tetiana, Barzylovych, Anastasia, Winkler, Karyn, Margarinos, Jessica, Martin, Dylan, Nowakowski, Maja, Joks, Rauno, Zangen, Tsili, Bernadsky, Olga, Boaz, Mona, Hermann, Gratiana, Aviv, Rachel, Kuperboim, Olga, Ramichanov, Larisa, Broide, Efrat, Shamir, Raanan, Zevit, Noam, Shaoul, Ron, Fich, Alex, Levine, Arie, Melamed, Isaac, Gangwar, Roopesh Singh, Minai-Fleminger, Yael, Seaf, Mansour, Gutgold, Amichai, Shikotra, Aarti, Chauhan, Anoop, Holgate, Stephen, Bradding, Peter, Howarth, Peter, Eliashar, Ron, Berkman, Neville, Levi-Schaffer, Francesca, Woo, Sung-il, Celik, Betul, Bulut, Tangul, Yalcin, Arzu Didem, Caldas, Luiz Querino, Confino-Cohen, Ronit, Rosman, Yossi, Goldberg, Arnon, Breuer, Oded, Singh, Roopesh, Barhoum, Ahlam, Kerem, Eitan, Slavyanskaya, Tatiana, Sepiashvili, Revaz, Blinova, Elena A., Pashkina, Ekaterina A., Leonova, Marina I., Nepomnyaschikh, Vera M., Demina, Darya V., Kozlov, Vladimir A., Shamri, Revital, Young, Kristen M., Weller, Peter F., de Paula Vieira, Rodolfo, Oliveira-Junior, Manoel Carneiro, Damasceno-Rodrigues, Nilsa Regina, Arantes-Costa, Fernanda Magalhães, Martins, Milton Arruda, Oliveira, Ana Paula Ligeiro, Bernard, Alfred, Sardella, Antonia, Voisin, Catherine, Royce, Simon, Philpott, Hamish, Nandurkar, Sanjay, Thien, Francis, Gibson, Peter, Bianchini, Rodolfo, Roth-Walter, Franziska, Ohradanova-Repic, Anna, Hofstetter, Gerlinde, Herrmann, Ina, Carvalho, Maria Isabel, Hufnagl, Karin, Bajna, Erika, Roth, Georg, Stockinger, Hannes, Jensen-Jarolim, Erika, Almog, Meital, Kessel, Aharon, Apov, Larisa, Salguero, Carlos Sanchez, Chacon, Alvaro Sanchez, Nazarov, Abbos, Ergashev, Shaxbos, Nesterova, Irina, Kovaleva, Svetlana, Chudilova, Galina, Lomtatidze, Ludmila, De Schryver, Sarah, Dery, Alizee, Clarke, Ann, Nadeau, Kari, Weatherall, Kimberly, Greenwood, Celia, Daley, Denise, Asai, Yuka, Ben-Shoshan, Moshe, Balmasova, Irina, Malova, Elena, Wagner, Stefanie, Pacios, Luis F., Wallner, Michael, Wiederstein, Markus, Tevs, Anna E., Tataurshchikova, Nataly, Sangidorj, Baigalmaa, Ronzhina, Anna, Chikhladze, Manana, Wirz, Oliver F., van de Veen, Willem, Mirer, David, Morita, Hideaki, Altunbulakli, Can, Johnston, Sebastian L., Glanville, Nicholas, Papadopoulos, Nikolaos G., Akdis, Cezmi A., Akdis, Mübeccel, Reshef, Avner, Riedl, Marc, Panovska, Vesna Grivcheva, Moldovan, Dumitru, Baker, James, Yang, William H., Andrejevic, Sladjana, Lockey, Richard F., Hakl, Roman, Kivity, Shmuel, Bellizzi, Luca, Harper, Joseph R., Relan, Anurag, and Cicardi, Marco

Subjects
lcsh:Immunologic diseases. Allergy, Pulmonary and Respiratory Medicine, 010504 meteorology & atmospheric sciences, business.industry, Immunology, Library science, Meeting Abstracts, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Immunology and Allergy, Medicine, lcsh:RC581-607, business, 0105 earth and related environmental sciences, Wechsler Intelligence Scale for Children
Published
2017
Full Text
View/download PDF

45. Allergic Rhinitis and its Impact on Asthma (ARIA): In collaboration with the World Health Organization

Author

Bousquet, J., Van Cauwenberge, P., Khaltaev, N., Aït Khaled, N., Annesi Maesano, I., Baena Cagnani, C., Bateman, E., Canonica, G. W., Carlsen, K. H., Demoly, P., Durham, S. R., Enarson, D., Fokkens, W. J., Gerth Van Wijk, R., Howarth, P., Ivanova, N. A., Kemp, J. P., Klossek, J. M., Lockey, R. F., Lund, V., Mackay, I., Malling, H. J., Meltzer, E. O., Mygind, N., Okuda, M., Pawankar, R., Price, D., Scadding, G. K., Simons, Estelle R., Szczeklik, A., Valovirta, E., Vignola, A. M., Wang, D. Y., Warner, J. O., Weiss, K. B., BONINI, Sergio, Bousquet, J., Van Cauwenberge, P., Khaltaev, N., Aït Khaled, N., Annesi Maesano, I., Baena Cagnani, C., Bateman, E., Bonini, Sergio, Canonica, G. W., Carlsen, K. H., Demoly, P., Durham, S. R., Enarson, D., Fokkens, W. J., Gerth Van Wijk, R., Howarth, P., Ivanova, N. A., Kemp, J. P., Klossek, J. M., Lockey, R. F., Lund, V., Mackay, I., Malling, H. J., Meltzer, E. O., Mygind, N., Okuda, M., Pawankar, R., Price, D., Scadding, G. K., Simons, Estelle R., Szczeklik, A., Valovirta, E., Vignola, A. M., Wang, D. Y., Warner, J. O., and Weiss, K. B.

Subjects
Immunology
Published
2002

46. Evaluation of the effects of non-medicinal ingredients on the in vitro characteristics and in vivo bioavailability of a sublingual tablet formulation of epinephrine

Author

Gong, Yuewen (Pharmacy) Hasinoff, Brian (Pharmacy) McNicol, Archie (Oral Biology) Wu, Shirley (University of Toronto), Simons, Keith (Pharmacy) Simons, Estelle (Pediatrics and Child Health), Rachid, Ousama, Gong, Yuewen (Pharmacy) Hasinoff, Brian (Pharmacy) McNicol, Archie (Oral Biology) Wu, Shirley (University of Toronto), Simons, Keith (Pharmacy) Simons, Estelle (Pediatrics and Child Health), and Rachid, Ousama

Abstract

Objectives: To review, develop, and validate appropriate methods for quality control testing of sublingual (SL) tablets; to formulate and characterize new generations of SL tablets of epinephrine (E) for the potential first-aid treatment of anaphylaxis; and to evaluate the effects of non-medicinal ingredients (NMIs) on the in vitro characteristics and in vivo bioavailability of the formulated tablets. Methods: A custom-made apparatus and a novel method that simulates SL conditions were evaluated for dissolution testing of SL tablets. An electronic tongue (e-Tongue) was used to assess the degree of E bitterness and to demonstrate the masking effects of sweetening and/or flavoring agents. The effect of several NMIs in various properties on the in vitro characteristics of new generations of E SL tablets was evaluated. Formulations with the best in vitro characteristics, containing E 30 mg and 40 mg, were evaluated in vivo using our validated rabbit model and compared with placebo SL tablets (negative control) and E 0.3 mg intramuscular (IM) injection (positive control). Results: The novel in vitro dissolution testing resulted in accurate and reproducible data and was capable of detecting the effect of minor changes in formulations. Using the e-Tongue, E bitartrate had an extremely bitter taste which was masked to various degrees by the addition of aspartame, acesulfame potassium, and citric acid alone or in combination. Citric acid alone masked the bitter taste by >80%. The evaluation of NMIs revealed that the best formulation contained specific proportions of mannitol and coarse and fine grades of microcrystalline cellulose. Appropriate comparative testing resulted in the selection of a taste-masked E SL formulation with optimum in vitro characteristics. This formulation containing E 40 mg resulted in similar bioavailability to E 0.3 mg IM. This formulation containing E 30 mg had higher bioavailability than placebo, but lower bioavailability than E 40 mg tablets. Conc

Published
2012

Catalog

Books, media, physical & digital resources
See catalog results