1. [The impact of BMI on the course of the acute SARS-COV-2 infection and the risks that emerge during the first year after the hospital discharge. Subanalysis evidence of the AKTIV and AKTIV 2 registries].
- Author
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Arutyunov AG, Tarlovskaya EI, Galstyan GR, Batluk TI, Bashkinov RA, Arutyunov GG, Belenkov YN, Konradi AO, Lopatin YM, Rebrov AP, Tereshchenko SN, Chesnikova AI, Hayrapetyan HG, Babin AP, Bakulin IG, Bakulina NV, Balykova LA, Blagonravova AS, Boldina MV, Butomo MI, Vaisberg AR, Galyavich AS, Gomonova VV, Grigoryeva NY, Gubareva IV, Demko IV, Evzerikhina AV, Zharkov AV, Zateishchikova AA, Kamilova UK, Kim ZF, Kuznetsova TY, Kulikov AN, Lareva NAV, Makarova EV, Malchikova SV, Nedogoda SV, Petrova MM, Pochinka IG, Protasov KV, Protsenko DN, Ruzanov DY, Saiganov SA, Sarybaev AS, Selezneva NM, Sugraliev AB, Fomin IV, Khlynova OV, Chizhova OY, Shaposhnik II, Schukarev DA, Abdrakhmanova AK, Avetisyan SA, Avoyan HG, Azaryan KK, Aimakhanova GT, Ayypova DA, Akunov AC, Alieva MK, Almukhambedova AR, Aparkina AV, Aruslanova OR, Ashina EY, Badina ONY, Barysheva OY, Batchaeva AS, Bitieva AM, Bikhteev IU, Borodulina NA, Bragin MV, Brazhnik VA, Budu AM, Bykova GA, Vagapova KR, Varlamova DD, Vezikova NN, Verbitskaya EA, Vilkova OE, Vinnikova EA, Vustina VV, Galova EA, Genkel VV, Giller DB, Gorshenina EI, Grigoryeva EV, Gubareva EY, Dabylova GM, Demchenko AI, Dolgikh OY, Duishobaev MY, Evdokimov DS, Egorova KE, Ermilova AN, Zheldybaeva AE, Zarechnova NV, Zimina YD, Ivanova SY, Ivanchenko EY, Ilina MV, Kazakovtseva MV, Kazymova EV, Kalinina YS, Kamardina NA, Karachenova AM, Karetnikov IA, Karoli NA, Karsiev MK, Kaskaeva DS, Kasymova KF, Kerimbekova ZB, Kim ES, Kiseleva NV, Klimenko DA, Klimova AV, Kovalishena OV, Kozlov SV, Kolmakova EV, Kolchinskaya TP, Kolyadich MI, Kondryakova OV, Konoval MP, Konstantinov DY, Konstantinova EA, Kordyukova VA, Koroleva EV, Kraposhina AY, Kryukova TV, Kuznetsova AS, Kuzmina TY, Kuzmichev KV, Kulchoroeva CK, Kuprina TV, Kuranova IAM, Kurenkova LVV, Kurchugina NY, Kushubakova NA, Levankova VI, Ledyaeva AA, Lisun TV, Lisyanskaya VE, Lyubavina NA, Magdeeva NA, Mazalov KV, Mayseenko VI, Makarova AS, Maripov AM, Markov NV, Marusina AA, Melnikov ES, Metlinskaya AI, Moiseenko NB, Muradova FN, Muradyan RG, Musaelyan SN, Nekaeva ES, Nikitina NM, Nifontov SE, Obolentseva EY, Obukhova AA, Ogurlieva BB, Odegova AA, Omarova YV, Omurzakova NA, Ospanova SO, Pavlova VA, Pakhomova EVP, Petrov LD, Plastinina SS, Platonov DA, Pogrebetskaya VAA, Polyakov DV, Polyakov DS, Ponomarenko EEV, Popova LL, Potanin AA, Prokofieva NA, Rabik YD, Rakov NA, Rakhimov AN, Rozanova NA, Samus IV, Serikbolkyzy S, Sidorkina YA, Simonov AA, Skachkova VV, Skvortsova RD, Skuridin DS, Solovieva DV, Solovieva IA, Sukhomlinova IM, Sushilova AG, Tagaeva DR, Titoykina YV, Tikhonova EP, Tokmin DS, Tolmacheva AA, Torgunakova MS, Trenogina KV, Trostyanetskaya NAA, Trofimov DA, Trubnikova MA, Tulichev AA, Tursunova AT, Ulanova ND, Fatenkov OV, Fedorishina OV, Fil TS, Fomina IY, Fominova IS, Frolova IA, Tsvinger SM, Tsoma VV, Cholponbaeva MB, Chudinovskikh TSI, Shavrin IV, Shevchenko OA, Shikhaliev DR, Shishkina EA, Shishkov KY, Shcherbakov SY, Shcherbakova GV, and Yausheva EA
- Subjects
- Humans, Middle Aged, SARS-CoV-2, Body Mass Index, Patient Discharge, Overweight, Hospitals, Obesity, COVID-19
- Abstract
Background: There is enough evidence of the negative impact of excess weight on the formation and progression of res piratory pathology. Given the continuing SARS-CoV-2 pandemic, it is relevant to determine the relationship between body mass index (BMI) and the clinical features of the novel coronavirus infection (NCI)., Aim: To study the effect of BMI on the course of the acute SARS-COV-2 infection and the post-covid period., Materials and Methods: AKTIV and AKTIV 2 are multicenter non-interventional real-world registers. The АКТИВ registry (n=6396) includes non-overlapping outpatient and inpatient arms with 6 visits in each. The АКТИВ 2 registry (n=2968) collected the data of hospitalized patients and included 3 visits. All subjects were divided into 3 groups: not overweight (n=2139), overweight (n=2931) and obese (n=2666)., Results: A higher BMI was significantly associated with a more severe course of the infection in the form of acute kidney injury (p=0.018), cytokine storm (p<0.001), serum C-reactive protein over 100 mg/l (p<0.001), and the need for targeted therapy (p<0.001) in the hospitalized patients. Obesity increased the odds of myocarditis by 1,84 times (95% confidence interval [CI]: 1,13-3,00) and the need for anticytokine therapy by 1,7 times (95% CI: 1,30-2,30).The patients with the 1st and 2nd degree obesity, undergoing the inpatient treatment, tended to have a higher probability of a mortality rate. While in case of morbid obesity patients this tendency is the most significant (odds ratio - 1,78; 95% CI: 1,13-2,70). At the same time, the patients whose chronical diseases first appeared after the convalescence period, and those who had certain complaints missing before SARS-CoV-2 infection, more often had BMI of more than 30 kg/m2 (p<0,001).Additionally, the odds of death increased by 2,23 times (95% CI: 1,05-4,72) within 3 months after recovery in obese people over the age of 60 yearsCONCLUSION. Overweight and/or obesity is a significant risk factor for severe course of the new coronavirus infection and the associated cardiovascular and kidney damage Overweight people and patients with the 1st and 2nd degree obesity tend to have a high risk of death of SARS-CoV-2 infection in both acute and post-covid periods. On top of that, in case of morbid obesity patients this tendency is statistically significant. Normalization of body weight is a strategic objective of modern medicine and can contribute to prevention of respiratory conditions, severe course and complications of the new coronavirus infection.
- Published
- 2023
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