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5. Contributors

Author

Acioglu, Cigdem, primary, Aftab, Kiran, additional, Al Omari, Safwan, additional, de Albuquerque Cacique New York, Beatriz Souza, additional, Alomari, Safwan, additional, Al-Sammarraie, Nadia, additional, Ames, Herb, additional, Amine, Ali, additional, Amo-Aparicio, Jesús, additional, Anderson, Malcolm, additional, de Araújo, Amanda Vitória Lacerda, additional, Arevalo-Martin, Angel, additional, Aziz, Namrah, additional, Barbonetti, Arcangelo, additional, Barbosa, Valéria Ribeiro Nogueira, additional, Barderas, M.G., additional, Bradley, John C., additional, Bras, Hélène, additional, Bresnahan (J.), James, additional, Brocard, Frédéric, additional, Bsat, Shadi, additional, Budd, Maggi A., additional, Care-Unger, Candice, additional, Castellini, Chiara, additional, Cerrel Bazo, Humberto A., additional, Chanbour, Hani, additional, Chio, Jonathon Chon Teng, additional, Corbacho-Alonso, N., additional, D’Andrea, Settimio, additional, D’souza, Maria M., additional, da Silva Fiorin, Fernando, additional, Daly, Robin M., additional, Desneves, Katherine J., additional, Dingu, Nejada, additional, do Espírito Santo, Caroline Cunha, additional, do Nascimento, Débora Araújo, additional, dos Santos Abilio, Mirelly, additional, Dravid, Anusha, additional, Dsouza, Jeanne Maria, additional, Edwards, W. Brent, additional, El Houshiemy, Mohamad Nabih, additional, Elkabes, Stella, additional, Enam, Syed Ather, additional, Fedorova, Jana, additional, Fehlings, Michael G., additional, Francavilla, Felice, additional, Francavilla, Sandro, additional, Ftouni, Louna, additional, Garcia-Ovejero, Daniel, additional, Golaszewski, Stefan, additional, Gosálvez, Jaime, additional, Grassner, Lukas, additional, Gumbel, Jason H., additional, Haider, Ifaz T., additional, Halaoui, Adham, additional, Han, Inbo, additional, Heary, Robert F., additional, Hong, James, additional, Horner, Philip J., additional, Huang, Ning, additional, Hubscher, Charles H., additional, Inamasu, Joji, additional, Ishiguro, Hiroyuki, additional, Jeon, Justin Y., additional, Johnston, Stephen D., additional, Jones, Kate, additional, Jure, Ignacio, additional, Kaito, Takashi, additional, Kaur, Prabhjot, additional, Kawtharani, Sarah, additional, Kellerova, Erika, additional, Kigerl, Kristina A., additional, Kim, Dong-il, additional, Kiss, Nicole, additional, Kobeissy, Firas, additional, Korupolu, Radha, additional, Kumar, Hemant, additional, Kumar, Pawan, additional, Labombarda, Florencia, additional, Ladak, Asma Akbar, additional, Lee, Jeongmin, additional, Li, Lun, additional, Liu (H.), Roger, additional, Loh, Eldon, additional, Mehta, Swati, additional, Mneimneh, Farah, additional, Molina-Holgado, Eduardo, additional, Motl, Robert W., additional, Mourino-Alvarez, L., additional, Moussalem, Charbel, additional, Mubarak, Fatima, additional, Mujtaba, Batool, additional, Nardone, Raffaele, additional, O’Carroll, Simon J., additional, Omeis, Ibrahim, additional, Orenczuk, Steve, additional, Orme, Patricia, additional, Özkan, İlknur, additional, Pavel, Jaroslav, additional, Penas, Clara, additional, Pendleton, James, additional, Popovich, Phillip G., additional, Pryor, Julie, additional, Ray, Swapan K., additional, Riberto, Marcelo, additional, Richardson, Elizabeth J., additional, Richardson, Emma V., additional, Royes, Luiz Fernando Freire, additional, Sarieddine, Rana, additional, Sastre-Oliva, T., additional, Sawaki, Lumy Adams, additional, Sayenko, Dimitry G., additional, Schnitzer, Thomas J., additional, Scoblionko, Benjamin, additional, Sheng, Zu-Hang, additional, Silveira, Stephanie L., additional, Simonian, Narina, additional, Simpson, Grahame, additional, Sinkjær, Thomas, additional, de Souza, Daniel Rubio, additional, Stampas, Argyrios, additional, Svirskis, Darren, additional, Taccola, Giuliano, additional, Tallavajhula, Sudha S., additional, Taylan, Seçil, additional, Teasell, Robert, additional, Thompson, Aiko K., additional, Toossi, Amirali, additional, Trinka, Eugen, additional, Trost, Zina, additional, Vargas-Baquero, Eduardo, additional, Ward, Leigh C., additional, Wu, Ligia Jia Lin, additional, Zamarioli, Ariane, additional, and Zavvarian, Mohammad-Masoud, additional

Published
2022
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6. Monthly treatment with romosozumab for 1 year increases bone mineral at the hip, but not the knee, in women with chronic spinal cord injury.

Author

Crack, Laura E, Simonian, Narina, Schnitzer, Thomas J, and Edwards, W Brent

Subjects
SUBCUTANEOUS injections, SPINAL cord injuries, FINITE element method, COMPUTED tomography, LEAD
Abstract

Bone loss below the level of neurological lesion is a well-known complication of spinal cord injury (SCI). To date, most research has focused on pharmaceutical intervention using antiresorptives to prevent bone loss during the acute phase of SCI; however, limited research has investigated treatments for established osteoporosis during chronic SCI. Romosozumab, a monoclonal antibody with both antiresorptive and anabolic effects, has demonstrated significant increases in BMD for women with established PMO. Therefore, the purpose of this study was to examine the efficacy of monthly treatment with romosozumab to improve DXA-derived areal BMD at the hip, and CT-derived BMC and strength at the hip and knee in women with chronic SCI and an inability to ambulate. Twelve female participants with chronic SCI were recruited to receive 1 yr of monthly subcutaneous injections of romosozumab (210 mg). DXA and CT scans were taken at baseline, and months 3, 6, and 12 to quantify bone mineral, and finite element (FE) analysis was used to predict bone strength. Longitudinal mixed effects models were employed to determine the impact of treatment on bone properties. After 12 mo of treatment, areal BMD at the lumbar spine and total hip were significantly increased with median changes of 10.2% (IQR: 8.3–15.2%, p <.001) and 4.2% (IQR: 3.4–7.7%, p  = .009), respectively. Improvements at the hip were primarily due to increases in trabecular, not cortical, bone and effects were sufficient to significantly increase FE-predicted strength by 20.3% (IQR: 9.5–37.0%, p  = .004). Treatment with romosozumab did not lead to any significant improvement in bone mineral at the distal femur or proximal tibia. These findings provide promising results for romosozumab treatment to improve bone mineral and reduce fracture risk at the hip, but not the knee, in women with chronic SCI. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Effects of Teriparatide and Vibration on Bone Mass and Bone Strength in People with Bone Loss and Spinal Cord Injury: A Randomized, Controlled Trial

Author

Edwards, W Brent, primary, Simonian, Narina, additional, Haider, Ifaz T, additional, Anschel, Alan S, additional, Chen, David, additional, Gordon, Keith E, additional, Gregory, Elaine K, additional, Kim, Ki H, additional, Parachuri, Ramadevi, additional, Troy, Karen L, additional, and Schnitzer, Thomas J, additional

Published
2018
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17. Reply to Letter to the Editor Regarding "Durability and Delayed Treatment Effects of Zoledronic Acid on Bone Loss After Spinal Cord Injury: A Randomized, Controlled Trial".

Author

Edwards, W. Brent, Haider, Ifaz T., Simonian, Narina, Barroso, Joana, and Schnitzer, Thomas J.

Abstract

Upper-extremity factures represent less than 11% of fragility fractures after SCI, SP ( sp 5,6 SP ) sp suggesting that lower-extremity bone loss, primarily that around the knee, is the most clinically relevant target for bone loss therapy. Singhania and Bhattacharya rightly point out that sublesional bone loss after SCI may continue to persist well beyond 2 years, and that a trial examining more than 2 years of zoledronic acid therapy would be desirable. To the Editors: We appreciate the compliments from Singhania and Bhattacharya regarding our recently completed randomized, controlled trial examining the efficacy of zoledronic acid to attenuate bone loss following spinal cord injury (SCI). [Extracted from the article]

Published
2022
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