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1. Systemic Sclerosis

Author

Man, Ada, Connolly, M. Kari, Simms, Robert W., Garg, Amit, editor, Merola, Joseph F., editor, and Fitzpatrick, Laura, editor

Published
2022
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2. Morphea

Author

Man, Ada, Connolly, M. Kari, Simms, Robert W., Garg, Amit, editor, Merola, Joseph F., editor, and Fitzpatrick, Laura, editor

Published
2022
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3. Abatacept in Early Diffuse Cutaneous Systemic Sclerosis: Results of a Phase II Investigator‐Initiated, Multicenter, Double‐Blind, Randomized, Placebo‐Controlled Trial

Author

Khanna, Dinesh, Spino, Cathie, Johnson, Sindhu, Chung, Lorinda, Whitfield, Michael L, Denton, Christopher P, Berrocal, Veronica, Franks, Jennifer, Mehta, Bhavan, Molitor, Jerry, Steen, Virginia D, Lafyatis, Robert, Simms, Robert W, Gill, Anna, Kafaja, Suzanne, Frech, Tracy M, Hsu, Vivien, Domsic, Robyn T, Pope, Janet E, Gordon, Jessica K, Mayes, Maureen D, Schiopu, Elena, Young, Amber, Sandorfi, Nora, Park, Jane, Hant, Faye N, Bernstein, Elana J, Chatterjee, Soumya, Castelino, Flavia V, Ajam, Ali, Wang, Yue, Wood, Tammara, Allanore, Yannick, Matucci‐Cerinic, Marco, Distler, Oliver, Singer, Ora, Bush, Erica, Fox, David A, and Furst, Daniel E

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Brain Disorders, Clinical Research, Clinical Trials and Supportive Activities, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Abatacept, Adult, Double-Blind Method, Female, Gene Expression, Gene Expression Profiling, Humans, Male, Middle Aged, Patient Reported Outcome Measures, Scleroderma, Diffuse, Sequence Analysis, RNA, Severity of Illness Index, Skin, Treatment Outcome, Tumor Necrosis Factor Inhibitors, Visual Analog Scale, Vital Capacity, Immunology, Public Health and Health Services, Arthritis & Rheumatology, Clinical sciences
Abstract

ObjectiveT cells play a key role in the pathogenesis of early systemic sclerosis. This study was undertaken to assess the safety and efficacy of abatacept in patients with diffuse cutaneous systemic sclerosis (dcSSc).MethodsIn this 12-month, randomized, double-blind, placebo-controlled trial, participants were randomized 1:1 to receive either subcutaneous abatacept 125 mg or matching placebo, stratified by duration of dcSSc. Escape therapy was allowed at 6 months for worsening disease. The coprimary end points were change in the modified Rodnan skin thickness score (MRSS) compared to baseline and safety over 12 months. Differences in longitudinal outcomes were assessed according to treatment using linear mixed models, with outcomes censored after initiation of escape therapy. Skin tissue obtained from participants at baseline was classified into intrinsic gene expression subsets.ResultsAmong 88 participants, the adjusted mean change in the MRSS at 12 months was -6.24 units for those receiving abatacept and -4.49 units for those receiving placebo, with an adjusted mean treatment difference of -1.75 units (P = 0.28). Outcomes for 2 secondary measures (Health Assessment Questionnaire disability index and a composite measure) were clinically and statistically significantly better with abatacept. The proportion of subjects in whom escape therapy was needed was higher in the placebo group relative to the abatacept group (36% versus 16%). In the inflammatory and normal-like skin gene expression subsets, decline in the MRSS over 12 months was clinically and significantly greater in the abatacept group versus the placebo group (P < 0.001 and P = 0.03, respectively). In the abatacept group, adverse events occurred in 35 participants versus 40 participants in the placebo group, including 2 deaths and 1 death, respectively.ConclusionIn this phase II trial, abatacept was well-tolerated, but change in the MRSS was not statistically significant. Secondary outcome measures, including gene expression subsets, showed evidence in support of abatacept. These data should be confirmed in a phase III trial.

Published
2020

4. Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis

Author

Rhodes, Christopher J, Batai, Ken, Bleda, Marta, Haimel, Matthias, Southgate, Laura, Germain, Marine, Pauciulo, Michael W, Hadinnapola, Charaka, Aman, Jurjan, Girerd, Barbara, Arora, Amit, Knight, Jo, Hanscombe, Ken B, Karnes, Jason H, Kaakinen, Marika, Gall, Henning, Ulrich, Anna, Harbaum, Lars, Cebola, Inês, Ferrer, Jorge, Lutz, Katie, Swietlik, Emilia M, Ahmad, Ferhaan, Amouyel, Philippe, Archer, Stephen L, Argula, Rahul, Austin, Eric D, Badesch, David, Bakshi, Sahil, Barnett, Christopher, Benza, Raymond, Bhatt, Nitin, Bogaard, Harm J, Burger, Charles D, Chakinala, Murali, Church, Colin, Coghlan, John G, Condliffe, Robin, Corris, Paul A, Danesino, Cesare, Debette, Stéphanie, Elliott, C Gregory, Elwing, Jean, Eyries, Melanie, Fortin, Terry, Franke, Andre, Frantz, Robert P, Frost, Adaani, Garcia, Joe GN, Ghio, Stefano, Ghofrani, Hossein-Ardeschir, Gibbs, J Simon R, Harley, John, He, Hua, Hill, Nicholas S, Hirsch, Russel, Houweling, Arjan C, Howard, Luke S, Ivy, Dunbar, Kiely, David G, Klinger, James, Kovacs, Gabor, Lahm, Tim, Laudes, Matthias, Machado, Rajiv D, Ross, Robert V MacKenzie, Marsolo, Keith, Martin, Lisa J, Moledina, Shahin, Montani, David, Nathan, Steven D, Newnham, Michael, Olschewski, Andrea, Olschewski, Horst, Oudiz, Ronald J, Ouwehand, Willem H, Peacock, Andrew J, Pepke-Zaba, Joanna, Rehman, Zia, Robbins, Ivan, Roden, Dan M, Rosenzweig, Erika B, Saydain, Ghulam, Scelsi, Laura, Schilz, Robert, Seeger, Werner, Shaffer, Christian M, Simms, Robert W, Simon, Marc, Sitbon, Olivier, Suntharalingam, Jay, Tang, Haiyang, Tchourbanov, Alexander Y, Thenappan, Thenappan, Torres, Fernando, Toshner, Mark R, Treacy, Carmen M, Noordegraaf, Anton Vonk, Waisfisz, Quinten, and Walsworth, Anna K

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Genetics, Human Genome, Lung, Aetiology, 2.1 Biological and endogenous factors, Cardiovascular, Female, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Genotyping Techniques, HLA-DP alpha-Chains, HLA-DP beta-Chains, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Pulmonary Arterial Hypertension, Risk Assessment, SOXF Transcription Factors, Signal Transduction, Survival Analysis, UK NIHR BioResource Rare Diseases Consortium, UK PAH Cohort Study Consortium, US PAH Biobank Consortium, Public Health and Health Services, Other Medical and Health Sciences, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundRare genetic variants cause pulmonary arterial hypertension, but the contribution of common genetic variation to disease risk and natural history is poorly characterised. We tested for genome-wide association for pulmonary arterial hypertension in large international cohorts and assessed the contribution of associated regions to outcomes.MethodsWe did two separate genome-wide association studies (GWAS) and a meta-analysis of pulmonary arterial hypertension. These GWAS used data from four international case-control studies across 11 744 individuals with European ancestry (including 2085 patients). One GWAS used genotypes from 5895 whole-genome sequences and the other GWAS used genotyping array data from an additional 5849 individuals. Cross-validation of loci reaching genome-wide significance was sought by meta-analysis. Conditional analysis corrected for the most significant variants at each locus was used to resolve signals for multiple associations. We functionally annotated associated variants and tested associations with duration of survival. All-cause mortality was the primary endpoint in survival analyses.FindingsA locus near SOX17 (rs10103692, odds ratio 1·80 [95% CI 1·55-2·08], p=5·13 × 10-15) and a second locus in HLA-DPA1 and HLA-DPB1 (collectively referred to as HLA-DPA1/DPB1 here; rs2856830, 1·56 [1·42-1·71], p=7·65 × 10-20) within the class II MHC region were associated with pulmonary arterial hypertension. The SOX17 locus had two independent signals associated with pulmonary arterial hypertension (rs13266183, 1·36 [1·25-1·48], p=1·69 × 10-12; and rs10103692). Functional and epigenomic data indicate that the risk variants near SOX17 alter gene regulation via an enhancer active in endothelial cells. Pulmonary arterial hypertension risk variants determined haplotype-specific enhancer activity, and CRISPR-mediated inhibition of the enhancer reduced SOX17 expression. The HLA-DPA1/DPB1 rs2856830 genotype was strongly associated with survival. Median survival from diagnosis in patients with pulmonary arterial hypertension with the C/C homozygous genotype was double (13·50 years [95% CI 12·07 to >13·50]) that of those with the T/T genotype (6·97 years [6·02-8·05]), despite similar baseline disease severity.InterpretationThis is the first study to report that common genetic variation at loci in an enhancer near SOX17 and in HLA-DPA1/DPB1 is associated with pulmonary arterial hypertension. Impairment of SOX17 function might be more common in pulmonary arterial hypertension than suggested by rare mutations in SOX17. Further studies are needed to confirm the association between HLA typing or rs2856830 genotyping and survival, and to determine whether HLA typing or rs2856830 genotyping improves risk stratification in clinical practice or trials.FundingUK NIHR, BHF, UK MRC, Dinosaur Trust, NIH/NHLBI, ERS, EMBO, Wellcome Trust, EU, AHA, ACClinPharm, Netherlands CVRI, Dutch Heart Foundation, Dutch Federation of UMC, Netherlands OHRD and RNAS, German DFG, German BMBF, APH Paris, INSERM, Université Paris-Sud, and French ANR.

Published
2019

6. Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma

Author

Sullivan, Keith M, Goldmuntz, Ellen A, Keyes-Elstein, Lynette, McSweeney, Peter A, Pinckney, Ashley, Welch, Beverly, Mayes, Maureen D, Nash, Richard A, Crofford, Leslie J, Eggleston, Barry, Castina, Sharon, Griffith, Linda M, Goldstein, Julia S, Wallace, Dennis, Craciunescu, Oana, Khanna, Dinesh, Folz, Rodney J, Goldin, Jonathan, St Clair, E William, Seibold, James R, Phillips, Kristine, Mineishi, Shin, Simms, Robert W, Ballen, Karen, Wener, Mark H, Georges, George E, Heimfeld, Shelly, Hosing, Chitra, Forman, Stephen, Kafaja, Suzanne, Silver, Richard M, Griffing, Leroy, Storek, Jan, LeClercq, Sharon, Brasington, Richard, Csuka, Mary E, Bredeson, Christopher, Keever-Taylor, Carolyn, Domsic, Robyn T, Kahaleh, M Bashar, Medsger, Thomas, and Furst, Daniel E

Subjects
Autoimmune Disease, Transplantation, Stem Cell Research - Nonembryonic - Human, Scleroderma, Clinical Trials and Supportive Activities, Clinical Research, Stem Cell Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Inflammatory and immune system, Good Health and Well Being, Adolescent, Adult, Aged, Cyclophosphamide, Disease-Free Survival, Female, Follow-Up Studies, Hematopoietic Stem Cell Transplantation, Humans, Immunosuppressive Agents, Infections, Intention to Treat Analysis, Kaplan-Meier Estimate, Male, Middle Aged, Scleroderma, Systemic, Transplantation Conditioning, Transplantation, Autologous, Young Adult, SCOT Study Investigators, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundDespite current therapies, diffuse cutaneous systemic sclerosis (scleroderma) often has a devastating outcome. We compared myeloablative CD34+ selected autologous hematopoietic stem-cell transplantation with immunosuppression by means of 12 monthly infusions of cyclophosphamide in patients with scleroderma.MethodsWe randomly assigned adults (18 to 69 years of age) with severe scleroderma to undergo myeloablative autologous stem-cell transplantation (36 participants) or to receive cyclophosphamide (39 participants). The primary end point was a global rank composite score comparing participants with each other on the basis of a hierarchy of disease features assessed at 54 months: death, event-free survival (survival without respiratory, renal, or cardiac failure), forced vital capacity, the score on the Disability Index of the Health Assessment Questionnaire, and the modified Rodnan skin score.ResultsIn the intention-to-treat population, global rank composite scores at 54 months showed the superiority of transplantation (67% of 1404 pairwise comparisons favored transplantation and 33% favored cyclophosphamide, P=0.01). In the per-protocol population (participants who received a transplant or completed ≥9 doses of cyclophosphamide), the rate of event-free survival at 54 months was 79% in the transplantation group and 50% in the cyclophosphamide group (P=0.02). At 72 months, Kaplan-Meier estimates of event-free survival (74% vs. 47%) and overall survival (86% vs. 51%) also favored transplantation (P=0.03 and 0.02, respectively). A total of 9% of the participants in the transplantation group had initiated disease-modifying antirheumatic drugs (DMARDs) by 54 months, as compared with 44% of those in the cyclophosphamide group (P=0.001). Treatment-related mortality in the transplantation group was 3% at 54 months and 6% at 72 months, as compared with 0% in the cyclophosphamide group.ConclusionsMyeloablative autologous hematopoietic stem-cell transplantation achieved long-term benefits in patients with scleroderma, including improved event-free and overall survival, at a cost of increased expected toxicity. Rates of treatment-related death and post-transplantation use of DMARDs were lower than those in previous reports of nonmyeloablative transplantation. (Funded by the National Institute of Allergy and Infectious Diseases and the National Institutes of Health; ClinicalTrials.gov number, NCT00114530 .).

Published
2018

7. Safety and efficacy of abatacept in early diffuse cutaneous systemic sclerosis (ASSET): open-label extension of a phase 2, double-blind randomised trial

Author

Chung, Lorinda, Spino, Cathie, McLain, Richard, Johnson, Sindhu R, Denton, Christopher P, Molitor, Jerry A, Steen, Virginia D, Lafyatis, Robert, Simms, Robert W, Kafaja, Suzanne, Frech, Tracy M, Hsu, Vivien, Domsic, Robyn T, Pope, Janet E, Gordon, Jessica K, Mayes, Maureen D, Sandorfi, Nora, Hant, Faye N, Bernstein, Elana J, Chatterjee, Soumya, Castelino, Flavia V, Ajam, Ali, Allanore, Yannick, Matucci-Cerinic, Marco, Whitfield, Michael L, Distler, Oliver, Singer, Ora, Young, Amber, Nagaraja, Vivek, Fox, David A, Furst, Daniel E, and Khanna, Dinesh

Published
2020
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8. The American College of Rheumatology Provisional Composite Response Index for Clinical Trials in Early Diffuse Cutaneous Systemic Sclerosis

Author

Khanna, Dinesh, Berrocal, Veronica J, Giannini, Edward H, Seibold, James R, Merkel, Peter A, Mayes, Maureen D, Baron, Murray, Clements, Philip J, Steen, Virginia, Assassi, Shervin, Schiopu, Elena, Phillips, Kristine, Simms, Robert W, Allanore, Yannick, Denton, Christopher P, Distler, Oliver, Johnson, Sindhu R, Matucci-Cerinic, Marco, Pope, Janet E, Proudman, Susanna M, Siegel, Jeffrey, Wong, Weng Kee, Wells, Athol U, and Furst, Daniel E

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Scleroderma, Inflammatory and immune system, Adult, Female, Humans, Male, Middle Aged, Psychometrics, Randomized Controlled Trials as Topic, Rheumatology, Scleroderma, Diffuse, Severity of Illness Index, Public Health and Health Services, Psychology, Clinical sciences, Allied health and rehabilitation science
Abstract

ObjectiveEarly diffuse cutaneous systemic sclerosis (dcSSc) is characterized by rapid changes in the skin and internal organs. The objective of this study was to develop a composite response index in dcSSc (CRISS) for use in randomized controlled trials (RCTs).MethodsWe developed 150 paper patient profiles with standardized clinical outcome elements (core set items) using patients with dcSSc. Forty scleroderma experts rated 20 patient profiles each and assessed whether each patient had improved or not improved over a period of 1 year. Using the profiles for which raters had reached a consensus on whether the patients were improved versus not improved (79% of the profiles examined), we fit logistic regression models in which the binary outcome referred to whether the patient was improved or not, and the changes in the core set items from baseline to followup were entered as covariates. We tested the final index in a previously completed RCT.ResultsSixteen of 31 core items were included in the patient profiles after a consensus meeting and review of test characteristics of patient-level data. In the logistic regression model in which the included core set items were change over 1 year in the modified Rodnan skin thickness score, the forced vital capacity, the patient and physician global assessments, and the Health Assessment Questionnaire disability index, sensitivity was 0.982 (95% confidence interval 0.982-0.983) and specificity was 0.931 (95% confidence interval 0.930-0.932), and the model with these 5 items had the highest face validity. Subjects with a significant worsening of renal or cardiopulmonary involvement were classified as not improved, regardless of improvements in other core items. With use of the index, the effect of methotrexate could be differentiated from the effect of placebo in a 1-year RCT (P = 0.02).ConclusionWe have developed a CRISS that is appropriate for use as an outcome assessment in RCTs of early dcSSc.

Published
2016

9. Antisense Long Non-Coding RNAs Are Deregulated in Skin Tissue of Patients with Systemic Sclerosis

Author

Messemaker, Tobias C., Chadli, Loubna, Cai, Guoshuai, Goelela, Varshna S., Boonstra, Maaike, Dorjée, Annemarie L., Andersen, Stefan N., Mikkers, Harald M.M., van ‘t Hof, Peter, Mei, Hailiang, Distler, Oliver, Draisma, Harmen H.M., Johnson, Michael E., Orzechowski, Nicole M., Simms, Robert W., Toes, Rene E.M., Aarbiou, Jamil, Huizinga, Tom W., Whitfield, Michael L., DeGroot, Jeroen, de Vries-Bouwstra, Jeska, and Kurreeman, Fina

Published
2018
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14. Efficacy and Safety of Lenabasum, a Cannabinoid Type 2 Receptor Agonist, in a Phase 3 Randomized Trial in Diffuse Cutaneous Systemic Sclerosis

Author

Spiera, Robert; https://orcid.org/0000-0003-2911-6800, Kuwana, Masataka; https://orcid.org/0000-0001-8352-6136, Khanna, Dinesh; https://orcid.org/0000-0003-1412-4453, Hummers, Laura; https://orcid.org/0000-0002-4864-4011, Frech, Tracy M, Stevens, Wendy, Matucci-Cerinic, Marco, Kafaja, Suzanne, Distler, Oliver; https://orcid.org/0000-0002-2413-1959, Jun, Jae-Bum; https://orcid.org/0000-0002-0208-0505, Levy, Yair, Leszcyzński, Piotr, Gordon, Jessica; https://orcid.org/0000-0001-8068-0592, Steen, Virginia, Lee, Eun Bong; https://orcid.org/0000-0003-0703-1208, Jankowski, Tomasz, Litinsky, Irena, Chung, Lorina, Hsu, Vivien, Mayes, Maureen; https://orcid.org/0000-0001-5070-2535, Sandorfi, Nora, Simms, Robert W, Finzel, Stephanie, de Vries-Bouwstra, Jeska, Constantine, Scott, Dgetluck, Nancy, Dinh, Quinn, Bloom, Bradley J, Furst, Daniel E, White, Barbara, et al, Spiera, Robert; https://orcid.org/0000-0003-2911-6800, Kuwana, Masataka; https://orcid.org/0000-0001-8352-6136, Khanna, Dinesh; https://orcid.org/0000-0003-1412-4453, Hummers, Laura; https://orcid.org/0000-0002-4864-4011, Frech, Tracy M, Stevens, Wendy, Matucci-Cerinic, Marco, Kafaja, Suzanne, Distler, Oliver; https://orcid.org/0000-0002-2413-1959, Jun, Jae-Bum; https://orcid.org/0000-0002-0208-0505, Levy, Yair, Leszcyzński, Piotr, Gordon, Jessica; https://orcid.org/0000-0001-8068-0592, Steen, Virginia, Lee, Eun Bong; https://orcid.org/0000-0003-0703-1208, Jankowski, Tomasz, Litinsky, Irena, Chung, Lorina, Hsu, Vivien, Mayes, Maureen; https://orcid.org/0000-0001-5070-2535, Sandorfi, Nora, Simms, Robert W, Finzel, Stephanie, de Vries-Bouwstra, Jeska, Constantine, Scott, Dgetluck, Nancy, Dinh, Quinn, Bloom, Bradley J, Furst, Daniel E, White, Barbara, and et al

Abstract

INTRODUCTION Efficacy and safety of lenabasum, a cannabinoid type 2-receptor agonist, was tested in a Phase 3 study in patients with diffuse cutaneous systemic sclerosis (dcSSc). METHODS A multi-national double-blind study was conducted in 365 dcSSc patients who were randomized and dosed 1:1:1 with lenabasum 20 mg, lenabasum 5 mg, or placebo, each twice daily and added to background treatments including immunosuppressive therapies (IST). RESULTS The primary endpoint, ACR Combined Response Index in dcSSc (ACR-CRISS) score at Week 52, lenabasum 20 mg BID versus placebo, was not met, with ACR-CRISS scores of 0.888 versus 0.887, P = 0.4972, mixed models repeated measures (MMRM). Change in modified Rodnan Skin Score (mRSS) at Week 52 was -6.7 versus -8.1 points for lenabasum 20 mg BID versus placebo, P = 0.1183, MMRM. Pre-specified analyses showed higher ACR-CRISS scores, greater improvement in mRSS, and less decline in forced vital capacity in subjects on background mycophenolate and those receiving IST for ≤ 1 year duration. No deaths or excess in serious or severe adverse events related to lenabasum were observed. CONCLUSIONS A benefit of lenabasum in dcSSc was not demonstrated. The majority of patients were treated with background IST, and treatment with MMF in particular was associated with better outcomes. This supports the use of IST in the treatment of dcSSc, and highlights the challenge of demonstrating a treatment effect when investigational treatment is added to standard of care IST. These findings have relevance to trial design in SSc, as well as clinical care. This article is protected by copyright. All rights reserved.

Published
2023

15. Antinuclear antibody-negative systemic sclerosis

Author

Salazar, Gloria A., Assassi, Shervin, Wigley, Fredrick, Hummers, Laura, Varga, John, Hinchcliff, Monique, Khanna, Dinesh, Schiopu, Elena, Phillips, Kristine, Furst, Daniel E., Steen, Virginia, Baron, Murray, Hudson, Marie, Taillefer, Suzanne S., Pope, Janet, Jones, Niall, Docherty, Peter, Khalidi, Nader A., Robinson, David, Simms, Robert W., Silver, Richard M., Frech, Tracy M., Fessler, Barri J., Molitor, Jerry A., Fritzler, Marvin J., Segal, Barbara M., Al-Kassab, Firas, Perry, Marilyn, Yang, Jeremy, Zamanian, Sara, Reveille, John D., Arnett, Frank C., Pedroza, Claudia, and Mayes, Maureen D.

Published
2015
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16. Efficacy and Safety of Lenabasum, a Cannabinoid Type 2 Receptor Agonist, in a Phase 3 Randomized Trial in Diffuse Cutaneous Systemic Sclerosis

Author

Spiera, Robert, Kuwana, Masataka, Khanna, Dinesh, Hummers, Laura, Frech, Tracy M, Stevens, Wendy, Matucci-Cerinic, Marco, Kafaja, Suzanne, Distler, Oliver, Jun, Jae-Bum, Levy, Yair, Leszcyzński, Piotr, Gordon, Jessica, Steen, Virginia, Lee, Eun Bong, Jankowski, Tomasz, Litinsky, Irena, Chung, Lorina, Hsu, Vivien, Mayes, Maureen, Sandorfi, Nora, Simms, Robert W, Finzel, Stephanie, de Vries-Bouwstra, Jeska, Constantine, Scott, Dgetluck, Nancy, Dinh, Quinn, Bloom, Bradley J, Furst, Daniel E, White, Barbara, et al, and University of Zurich

Subjects
10051 Rheumatology Clinic and Institute of Physical Medicine, 610 Medicine & health
Published
2023
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18. Immunochip Analysis Identifies Multiple Susceptibility Loci for Systemic Sclerosis

Author

Ortego-Centeno, Norberto, Ríos, Raquel, Callejas, José Luis, Navarrete, Nuria, García Portales, Rosa, Camps, María Teresa, Fernández-Nebro, Antonio, González-Escribano, María F., Sánchez-Román, Julio, García-Hernández, Francisco José, Castillo, María Jesús, Aguirre, María Ángeles, Gómez-Gracia, Inmaculada, Fernández-Gutiérrez, Benjamín, Rodríguez-Rodríguez, Luis, Vicente, Esther, Andreu, José Luis, Fernández de Castro, Mónica, García de la Peña, Paloma, López-Longo, Francisco Javier, Martínez, Lina, Fonollosa, Vicente, Espinosa, Gerard, Tolosa, Carlos, Pros, Anna, Rodríguez Carballeira, Mónica, Narváez, Francisco Javier, Rubio Rivas, Manel, Ortiz Santamaría, Vera, Díaz, Bernardino, Trapiella, Luis, Freire, María del Carmen, Sousa, Adrián, Egurbide, María Victoria, Fanlo Mateo, Patricia, Sáez-Comet, Luis, Díaz, Federico, Hernández, Vanesa, Beltrán, Emma, Román-Ivorra, José Andrés, Grau, Elena, Alegre Sancho, Juan José, Blanco García, Francisco J., Oreiro, Natividad, Fernández Sueiro, Luis, Mayes, Maureen D., Bossini-Castillo, Lara, Gorlova, Olga, Martin, José Ezequiel, Zhou, Xiaodong, Chen, Wei V., Assassi, Shervin, Ying, Jun, Tan, Filemon K., Arnett, Frank C., Reveille, John D., Guerra, Sandra, Teruel, María, Carmona, Francisco David, Gregersen, Peter K., Lee, Annette T., López-Isac, Elena, Ochoa, Eguzkine, Carreira, Patricia, Simeón, Carmen Pilar, Castellví, Iván, González-Gay, Miguel Ángel, Zhernakova, Alexandra, Padyukov, Leonid, Alarcón-Riquelme, Marta, Wijmenga, Cisca, Brown, Matthew, Beretta, Lorenzo, Riemekasten, Gabriela, Witte, Torsten, Hunzelmann, Nicolas, Kreuter, Alexander, Distler, Jörg H.W., Voskuyl, Alexandre E., Schuerwegh, Annemie J., Hesselstrand, Roger, Nordin, Annika, Airó, Paolo, Lunardi, Claudio, Shiels, Paul, van Laar, Jacob M., Herrick, Ariane, Worthington, Jane, Denton, Christopher, Wigley, Fredrick M., Hummers, Laura K., Varga, John, Hinchcliff, Monique E., Baron, Murray, Hudson, Marie, Pope, Janet E., Furst, Daniel E., Khanna, Dinesh, Phillips, Kristin, Schiopu, Elena, Segal, Barbara M., Molitor, Jerry A., Silver, Richard M., Steen, Virginia D., Simms, Robert W., Lafyatis, Robert A., Fessler, Barri J., Frech, Tracy M., AlKassab, Firas, Docherty, Peter, Kaminska, Elzbieta, Khalidi, Nader, Jones, Henry Niall, Markland, Janet, Robinson, David, Broen, Jasper, Radstake, Timothy R.D.J., Fonseca, Carmen, Koeleman, Bobby P., and Martin, Javier

Published
2014
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23. Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD-1, TIGIT, and TIM-3 in Lymphocytes From Patients With Systemic Sclerosis

Author

Massachusetts Institute of Technology. Department of Biological Engineering, Fleury, Michelle, Belkina, Anna C, Proctor, Elizabeth A, Zammitti, Christopher, Simms, Robert W, Lauffenburger, Douglas A, Snyder-Cappione, Jennifer E, Lafyatis, Robert, Dooms, Hans, Massachusetts Institute of Technology. Department of Biological Engineering, Fleury, Michelle, Belkina, Anna C, Proctor, Elizabeth A, Zammitti, Christopher, Simms, Robert W, Lauffenburger, Douglas A, Snyder-Cappione, Jennifer E, Lafyatis, Robert, and Dooms, Hans

Abstract

© 2017, American College of Rheumatology Objective: Immune dysfunction is an important component of the disease process underlying systemic sclerosis (SSc), but the mechanisms contributing to altered immune cell function in SSc remain poorly defined. This study was undertaken to measure the expression and function of the coinhibitory receptors (co-IRs) programmed cell death 1 (PD-1), T cell immunoglobulin and ITIM domain (TIGIT), T cell immunoglobulin and mucin domain 3 (TIM-3), and lymphocyte activation gene 3 (LAG-3) in lymphocyte subsets from the peripheral blood of patients with SSc. Methods: Co-IR expression levels on subsets of immune cells were analyzed using a 16-color flow cytometry panel. The functional role of co-IRs was determined by measuring cytokine production after in vitro stimulation of SSc and healthy control peripheral blood mononuclear cells (PBMCs) in the presence of co-IR–blocking antibodies. Supernatants from cultures of stimulated PBMCs were added to SSc fibroblasts, and their impact on fibroblast gene expression was measured. Mathematical modeling was used to reveal differences between co-IR functions in SSc patients and healthy controls. Results: Levels of the co-IRs PD-1 and TIGIT were increased, and each was coexpressed, in distinct T cell subsets from SSc patients compared to healthy controls. Levels of TIM-3 were increased in SSc natural killer cells. PD-1, TIGIT, and TIM-3 antibody blockade revealed patient-specific roles of each of these co-IRs in modulating activation-induced T cell cytokine production. In contrast to healthy subjects, blockade of TIGIT and TIM-3, but not PD-1, failed to reverse inhibited cytokine production in SSc patients, indicating that enhanced T cell exhaustion is present in SSc. Finally, cytokines secreted in anti–TIM-3–treated PBMC cultures distinctly changed the gene expression profile in SSc fibroblasts. Conclusion: The altered expression and regulatory capacity of co-IRs in SSc lymphocytes may contribute

Published
2022

25. Cardiac Involvement in Secondary Amyloidosis

Author

Simms, Robert W., Coats, Mary H., Skinner, Martha, Cohen, Alan S., Falk, Rodney H., Natvig, Jacob B., editor, Førre, Øystein, editor, Husby, Gunnar, editor, Husebekk, Anne, editor, Skogen, Bjørn, editor, Sletten, Knut, editor, and Westermark, Per, editor

Published
1991
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30. Contributors

Author

Abdellatif, Engy, primary, Abeles, Aryeh M., additional, Abelson, Abby G., additional, Abhishek, Abhishek, additional, Abramson, Steven B., additional, Adachi, Jonathan D., additional, Adams, Michael A., additional, Aigner, Thomas, additional, Akira, Shizuo, additional, Aletaha, Daniel, additional, Aliprantis, Antonios O., additional, Almeida de Jesus, Adriana, additional, Altman, Roy D., additional, Amigo, Mary-Carmen, additional, Aringer, Martin, additional, Ascherman, Dana P., additional, Assassi, Shervin, additional, Atamas, Sergei P., additional, Azevedo, Pedro Ming, additional, Baer, Alan N., additional, Baeten, Dominique, additional, Baines, Colin, additional, Baker, Nancy A., additional, Balogh, Emese, additional, Balsa, Alejandro, additional, Baraliakos, Xenofon, additional, Bardin, Thomas, additional, Barnsley, Les, additional, Bathon, Joan M., additional, Bauch, Angela, additional, Belch, Jill J.F., additional, Bellamy, Nicholas, additional, Bellido, Teresita, additional, Benjamin, Michael, additional, Beresford, Michael W., additional, Berman, Brian, additional, Bermas, Bonnie Lee, additional, Bertsias, George, additional, Bilezikian, John P., additional, Bilginer, Yelda, additional, Birnbaum, Julius, additional, Bishop, Felicity L., additional, Bleasel, Jane F., additional, Böhm, Markus, additional, Bolster, Marcy B., additional, Bombardieri, Stefano, additional, Bonelli, Michael, additional, Bonnick, Sydney L., additional, Boumpas, Dimitrios T., additional, Bozec, Aline, additional, Brasington, Richard D., additional, Braun, Juergen, additional, Brown, Matthew A., additional, Bruce, Ian N., additional, Bugbee, William D., additional, Bukhari, Marwan A.S., additional, Burgos-Vargas, Rubén, additional, Burmester, Gerd-Rüdiger, additional, Burns, Jane C., additional, Burr, David B., additional, Buttgereit, Frank, additional, Bykerk, Vivian P., additional, Calabrese, Leonard H., additional, Callen, Jeffrey P., additional, Cavallo, Sabrina, additional, Cawston, Tim E., additional, Chandran, Vinod, additional, Chard, Michael Denis, additional, Chaudhary, Prateek, additional, Chen, Lan X., additional, Choi, Hyon K., additional, Choy, Ernest H., additional, Christopher-Stine, Lisa, additional, Chu, Alvina D., additional, Clauw, Daniel J., additional, Clements, Philip J., additional, Clowse, Megan E.B., additional, Coghlan, J. Gerry, additional, Conaghan, Philip G., additional, Cooper, Cyrus, additional, Costenbader, Karen H., additional, Creamer, Paul, additional, Crispín, José C., additional, Cronstein, Bruce N., additional, Cross, Raymond, additional, Cusano, Natalie E., additional, Cutolo, Maurizio, additional, D'Adamo, Chris, additional, D'Agati, Vivette, additional, D'Cruz, David P., additional, Dagfinrud, Hanne, additional, Daikh, David I., additional, Dalbeth, Nicola, additional, Dalton, Seamus E., additional, Dass, Shouvik, additional, Davis, Aileen M., additional, De Ceulaer, Karel, additional, Deal, Chad L., additional, Deane, Kevin D., additional, Della Rossa, Alessandra, additional, Dellaripa, Paul F., additional, Dennison, Elaine, additional, Denton, Christopher P., additional, Dieppe, Paul, additional, Doherty, Michael, additional, Dolan, Patricia, additional, Donn, Rachelle, additional, Dvorkina, Olga, additional, Dyer, George S.M., additional, Eastell, Richard, additional, Edwards, N. Lawrence, additional, Emery, Paul, additional, Erturan, Gurhan, additional, Espinoza, Luis R., additional, Eyre, Steve, additional, Fanouriakis, Antonios C., additional, Farber, Joshua, additional, Farrokhi, Shawn, additional, Fasth, Anders, additional, Feist, Eugen, additional, Feldman, Debbie, additional, Felson, David T., additional, Fisk, John D., additional, Fitzgerald, G. Kelley, additional, Flores, Raymond H., additional, Fox, David A., additional, Francomano, Clair A., additional, Frangos, Jennifer, additional, Freemont, Anthony J., additional, Fricka, Kevin B., additional, Furst, Daniel E., additional, Gabay, Cem, additional, Gadina, Massimo, additional, Gaston, J.S. Hill, additional, Gay, Steffen, additional, Gensler, Lianne S., additional, Geraldino-Pardilla, Laura, additional, Gerlag, Danielle M., additional, Ginzler, Ellen M., additional, Gizinski, Alison M., additional, Gladman, Dafna D., additional, Gold, Garry E., additional, Goldbach-Mansky, Raphaela, additional, Goldingay, Sarah, additional, Gordon, Sharon M., additional, Gorodkin, Rachel, additional, Goronzy, Jörg J., additional, Görtz, Simon, additional, Grahame, Rodney, additional, Grainger, Andrew J., additional, Gravallese, Ellen M., additional, Greenberg, Jeffrey D., additional, Gujar, Bansari, additional, Hagan, Matilda, additional, Hagley, Karlene, additional, Hakim, Alan J., additional, Hall, John C., additional, Hamuryudan, Vedat, additional, Hanly, John G., additional, Hanson, Eric P., additional, Haraoui, Boulos, additional, Harley, John B., additional, Hashkes, Philip J., additional, Hawker, Gillian A., additional, Hawkins, Philip N., additional, Heiberg, Turid, additional, Heinegård, Dick, additional, Helfgott, Simon M., additional, Ho, Pauline Y.P., additional, Hochberg, Marc C., additional, Hochman, Jacqueline, additional, Hodgkiss-Harlow, Chelsea J., additional, Hoffman, Robert W., additional, Hoffmann, Markus, additional, Holers, V. Michael, additional, Holick, Michael F., additional, Holroyd, Christopher, additional, Hübscher, Osvaldo, additional, Hunter, David J., additional, Husni, M. Elaine, additional, Inman, Robert D., additional, Isaac, Zacharia, additional, Iversen, Maura D., additional, Jabs, Douglas A., additional, Jackson, William, additional, Jaimungal, Sarada, additional, James, Judith A., additional, Javier, Rose-Marie, additional, Johnsen, Alyssa K., additional, Jordan, Joanne M., additional, Kaisho, Tsuneyasu, additional, Kallenberg, Cees G.M., additional, Kane, David, additional, Kapoor, Mohit, additional, Karlson, Elizabeth W., additional, Kassimos, Dimitrios G., additional, Kastner, Daniel L., additional, Katz, Jeffrey N., additional, Kay, Jonathan, additional, Kelly, Jennifer A., additional, Keystone, Edward, additional, Khamashta, Munther A., additional, Khanna, Dinesh, additional, Kjeken, Ingvild, additional, Koch, Alisa E., additional, Koff, Matthew F., additional, Kottyan, Leah, additional, Koutsogeorgopoulou, Loukia A., additional, Kraus, Virginia Byers, additional, Kumar, Pradeep, additional, Kvien, Tore K., additional, Lafyatis, Robert, additional, Landewé, Robert B.M., additional, Langford, Carol A., additional, Lau, Arthur N., additional, Laxer, Ronald M., additional, Learch, Thomas J., additional, Lewith, George, additional, Li, Yi, additional, Liao, Katherine P., additional, Littlejohn, Geoffrey, additional, Lorenzo, Pilar, additional, Luger, Thomas A., additional, Lundberg, Ingrid E., additional, Lundberg, Karin, additional, Machold, Klaus P., additional, MacKenzie, C. Ronald, additional, Mahr, Alfred D., additional, Manheimer, Eric, additional, Marini, Joan C., additional, Marquez, Javier, additional, Marsden, Debbie, additional, Martel-Pelletier, Johanne, additional, Martín-Mola, Emilio, additional, Martínez-Lavín, Manuel, additional, Massarotti, Elena M., additional, Matteson, Eric L., additional, Matzat, Stephen J., additional, Mayahi, Reza, additional, Mayes, Maureen Davidica, additional, McAlindon, Timothy, additional, McBain, Hayley, additional, McCarberg, Bill, additional, McCarthy, Edward F., additional, McCarthy, Geraldine, additional, McDermott, Michael F., additional, McGonagle, Dennis, additional, McLean, Lachy, additional, Merkel, Peter A., additional, Mikdashi, Jamal A., additional, Miller, Frederick W., additional, Miller, Paul D., additional, Minden, Kirsten, additional, Monach, Paul A., additional, Mulligan, Kathleen, additional, Namur, Gauthier, additional, Naredo, Esperanza, additional, Naylor, Kim E., additional, Nelson, Amanda E., additional, Newman, Stanton P., additional, Nordal, Ellen, additional, Nöth, Ulrich, additional, Ntatsaki, Eleana, additional, O'Shea, John J., additional, Oddis, Chester V., additional, Olivé, Alejandro, additional, Omair, Mohammed A., additional, Ombrello, Michael J., additional, Omisade, Antonina, additional, Ong, Voon H., additional, Önnerfjord, Patrik, additional, Orcel, Philippe, additional, Ospelt, Caroline, additional, Ozen, Seza, additional, Paget, Stephen A., additional, Patel, Dipak R., additional, Patrono, Carlo, additional, Pelletier, Jean-Pierre, additional, Pereira, Rosa Maria Rodrigues, additional, Pilkington, Clarissa A., additional, Pillinger, Michael H., additional, Pineda, Carlos, additional, Plenge, Robert M., additional, Price, Andrew, additional, Pricop, Luminita, additional, Rackwitz, Lars, additional, Ravelli, Angelo, additional, Redmond, Anthony C., additional, Reeves, Westley H., additional, Remmers, Elaine F., additional, Requena, Luis, additional, Ribbens, Clio, additional, Richardson, Bruce C., additional, Riera Alonso, Elena, additional, Riley, Graham, additional, Ritchlin, Christopher, additional, Ritter, Susan Y., additional, Rosas, Ivan O., additional, Rowan, Drew D., additional, Rudwaleit, Martin, additional, Rull, Marina, additional, Rygg, Marite, additional, Saag, Kenneth G., additional, Salmon, Jane E., additional, Salter, Donald M., additional, Salzberg, Daniel J., additional, Sambrook, Philip N., additional, Saxne, Tore, additional, Schaible, Hans-Georg, additional, Scher, Jose U., additional, Schett, Georg, additional, Schmitz, Nicole, additional, Schreiber, Benjamin, additional, Schumacher, H. Ralph, additional, Schwartz, Daniella Muallem, additional, Scott, David G.I., additional, Seton, Margaret, additional, Shapiro, Lauren M., additional, Sharby, Nancy, additional, Siegel, Jeffrey, additional, Siegel, Richard M., additional, Sieper, Joachim, additional, Silver, Richard M., additional, Silverberg, Shonni J., additional, Simard, Julia F., additional, Simmons, Barry P., additional, Simms, Robert W., additional, Singer, Nora G., additional, Smith, Malcolm D., additional, Smith, Stacy E., additional, Smolen, Josef S., additional, Spector, Tim D., additional, Steen, Virginia D., additional, Steere, Allen C., additional, Steiner, Günter, additional, Steinert, Andre F., additional, Stojan, George, additional, Stone, John H., additional, Strand, Vibeke, additional, Straub, Rainer H., additional, Streeten, Elizabeth A., additional, Superti-Furga, Giulio, additional, Symmons, Deborah P.M., additional, Szekanecz, Zoltan, additional, Tak, Paul P., additional, Tavoni, Antonio, additional, Taylor, Peter C., additional, Terkeltaub, Robert, additional, Thomas, Sarah S., additional, Thorne, Jennifer E., additional, Tobias, Jonathan H., additional, Tremoulet, Adriana H., additional, Tsokos, George C., additional, Tuan, Rocky S., additional, Turesson, Carl, additional, Unizony, Sebastian H., additional, Valdes, Ana M., additional, van den Berg, Wim B., additional, van der Heijde, Désirée, additional, van Vollenhoven, Ronald Frits, additional, Varga, John, additional, Vassilopoulos, Dimitrios, additional, Vital, Edward M., additional, Walker-Bone, Karen, additional, Wallace, Daniel J., additional, Warburton, Gary, additional, Ward, Robert J., additional, Watts, Richard, additional, Wechalekar, Mihir D., additional, Wedderburn, Lucy R., additional, Weinblatt, Michael E., additional, Weir, Matthew R., additional, Wenham, Claire Y.J., additional, West, Sterling G., additional, Weyand, Cornelia M., additional, White, Kenneth E., additional, Winthrop, Kevin L., additional, Wong, John B., additional, Woolf, Anthony D., additional, Worthington, Jane, additional, Xu, Huji, additional, Yazici, Hasan, additional, Young, D.A., additional, Yurdakul, Sebahattin, additional, Zhang, Yuqing, additional, and Zhuang, Haoyang, additional

Published
2015
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31. Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD-1, TIGIT, and TIM-3 in Lymphocytes From Patients With Systemic Sclerosis

Author

Fleury, Michelle, Belkina, Anna C, Proctor, Elizabeth A, Zammitti, Christopher, Simms, Robert W, Lauffenburger, Douglas A, Snyder-Cappione, Jennifer E, Lafyatis, Robert, Dooms, Hans, Fleury, Michelle, Belkina, Anna C, Proctor, Elizabeth A, Zammitti, Christopher, Simms, Robert W, Lauffenburger, Douglas A, Snyder-Cappione, Jennifer E, Lafyatis, Robert, and Dooms, Hans

Abstract

© 2017, American College of Rheumatology Objective: Immune dysfunction is an important component of the disease process underlying systemic sclerosis (SSc), but the mechanisms contributing to altered immune cell function in SSc remain poorly defined. This study was undertaken to measure the expression and function of the coinhibitory receptors (co-IRs) programmed cell death 1 (PD-1), T cell immunoglobulin and ITIM domain (TIGIT), T cell immunoglobulin and mucin domain 3 (TIM-3), and lymphocyte activation gene 3 (LAG-3) in lymphocyte subsets from the peripheral blood of patients with SSc. Methods: Co-IR expression levels on subsets of immune cells were analyzed using a 16-color flow cytometry panel. The functional role of co-IRs was determined by measuring cytokine production after in vitro stimulation of SSc and healthy control peripheral blood mononuclear cells (PBMCs) in the presence of co-IR–blocking antibodies. Supernatants from cultures of stimulated PBMCs were added to SSc fibroblasts, and their impact on fibroblast gene expression was measured. Mathematical modeling was used to reveal differences between co-IR functions in SSc patients and healthy controls. Results: Levels of the co-IRs PD-1 and TIGIT were increased, and each was coexpressed, in distinct T cell subsets from SSc patients compared to healthy controls. Levels of TIM-3 were increased in SSc natural killer cells. PD-1, TIGIT, and TIM-3 antibody blockade revealed patient-specific roles of each of these co-IRs in modulating activation-induced T cell cytokine production. In contrast to healthy subjects, blockade of TIGIT and TIM-3, but not PD-1, failed to reverse inhibited cytokine production in SSc patients, indicating that enhanced T cell exhaustion is present in SSc. Finally, cytokines secreted in anti–TIM-3–treated PBMC cultures distinctly changed the gene expression profile in SSc fibroblasts. Conclusion: The altered expression and regulatory capacity of co-IRs in SSc lymphocytes may contribute

Published
2021

32. 2013 Classification Criteria for Systemic Sclerosis: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative

Author

van den Hoogen, Frank, Khanna, Dinesh, Fransen, Jaap, Johnson, Sindhu R., Baron, Murray, Tyndall, Alan, Matucci-Cerinic, Marco, Naden, Raymond P., Medsger, Thomas A., Jr., Carreira, Patricia E., Riemekasten, Gabriela, Clements, Philip J., Denton, Christopher P., Distler, Oliver, Allanore, Yannick, Furst, Daniel E., Gabrielli, Armando, Mayes, Maureen D., van Laar, Jacob M., Seibold, James R., Czirjak, Laszlo, Steen, Virginia D., Inanc, Murat, Kowal-Bielecka, Otylia, Müller-Ladner, Ulf, Valentini, Gabriele, Veale, Douglas J., Vonk, Madelon C., Walker, Ulrich A., Chung, Lorinda, Collier, David H., Csuka, Mary Ellen, Fessler, Barri J., Guiducci, Serena, Herrick, Ariane, Hsu, Vivien M., Jimenez, Sergio, Kahaleh, Bashar, Merkel, Peter A., Sierakowski, Stanislav, Silver, Richard M., Simms, Robert W., Varga, John, and Pope, Janet E.

Published
2013
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36. Contributors

Author

Abeles, Aryeh M., primary, Abelson, Abby G., additional, Abhishek, Abhishek, additional, Abramson, Steven B., additional, Adams, Michael A., additional, Adlam, David M., additional, Aigner, Thomas, additional, Akira, Shizuo, additional, Aksentijevich, Ivona, additional, Aletaha, Daniel, additional, Aliprantis, Antonios O., additional, Allaart, Cornelia F., additional, Allen, Pamela G., additional, Altman, Roy D., additional, Aringer, Martin, additional, Ascherman, Dana P., additional, Assassi, Shervin, additional, Atamas, Sergei P., additional, Baer, Alan N., additional, Baeten, Dominique, additional, Baker, Nancy, additional, Balsa, Alejandro, additional, Barnsley, Les, additional, Bathon, Joan M., additional, Becker, Michael A., additional, Belch, Jill JF, additional, Bellamy, Nicholas, additional, Bellido, Teresita, additional, Benitez, R. Michael, additional, Benjamin, Michael, additional, Beresford, Michael W., additional, Berman, Brian M., additional, Bermas, Bonnie Lee, additional, Bertsias, George, additional, Bilezikian, John P., additional, Blazar, Philip E., additional, Bleasel, Jane F., additional, Böhm, Markus, additional, Boileau, Christelle, additional, Bolster, Marcy B., additional, Bombardieri, Stefano, additional, Bonnick, Sydney, additional, Boumpas, Dimitrios T., additional, Brasington, Richard D., additional, Breedveld, Ferdinand, additional, Brien, Earl W., additional, Brower, Anne C., additional, Brown, Matthew A., additional, Bruce, Ian N., additional, Bugbee, William D., additional, Bukhari, Marwan A.S., additional, Burgos-Vargas, Rubén, additional, Burns, Jane C., additional, Burr, David B., additional, Cagnoli, Patricia C., additional, Calabrese, Leonard H., additional, Callen, Jeffrey P., additional, Canoso, Juan J., additional, Cavallo, Sabrina, additional, Cawston, Tim E., additional, Chard, Michael Denis, additional, Chen, Lan X., additional, Choy, Ernest H.S., additional, Clauw, Daniel J., additional, Clements, Philip J., additional, Colburn, Nona T., additional, Coleman, Laura A., additional, Conaghan, Philip G., additional, Cooper, Cyrus, additional, Cosman, Felicia, additional, Costenbader, Karen H., additional, Creamer, Paul, additional, Crispin, José C., additional, Criswell, Lindsey A., additional, Cronstein, Bruce N., additional, Cross, Raymond, additional, Cusano, Natalie E., additional, Cush, John J., additional, Cutolo, Maurizio, additional, D’Agati, Vivette, additional, Dagfinrud, Hanne, additional, Daikh, David I., additional, Dalton, Seamus E., additional, Dass, Shouvik, additional, David, Jean-Pierre, additional, Davis, Aileen, additional, Deal, Chad L., additional, De Ceulaer, Karel, additional, Deighton, Chris, additional, Dellaripa, Paul F., additional, Rossa, Alessandra Della, additional, Dempster, David, additional, Dennison, Elaine, additional, Denton, Christopher P., additional, Denton, John, additional, Dhawale, Roshan, additional, Doherty, Michael, additional, Dolan, Patricia, additional, Donn, Rachelle, additional, Dooley, Mary Anne, additional, Dougados, Maxime, additional, Drummond, Michael F., additional, Dyer, George S.M., additional, Earp, Brandon E., additional, Edwards, N. Lawrence, additional, Ellender, Patrick, additional, Emery, Paul, additional, Espinoza, Luis R., additional, Farber, Joshua M., additional, Fasth, Anders, additional, Feldman, Debbie, additional, Felson, David T., additional, Fitzgerald, G. Kelley, additional, Flores, Raymond H., additional, Fox, David A., additional, Francomano, Clair A., additional, Freemont, Anthony J., additional, Fresko, Izzet, additional, Fricka, Kevin B., additional, Furst, Daniel E., additional, Gabay, Cem, additional, Gabriel, Sherine E., additional, Galarraga, Bernat, additional, Gäre, Boel Andersson, additional, Garnero, Patrick, additional, Gensler, Lianne S., additional, Gerlag, Danielle M., additional, Geusens, Piet P., additional, Giles, Jon T., additional, Ginzler, Ellen M., additional, Gizinski, Alison M., additional, Gold, Garry, additional, Gonzalez-Rivera, Tania, additional, Gordon, Caroline, additional, Gorodkin, Rachel, additional, Goronzy, Jorg J., additional, Görtz, Simon, additional, Gournelos, Elena, additional, Grahame, Rodney, additional, Grainger, Andrew J., additional, Gravallese, Ellen M., additional, Greenberg, Jeffrey D., additional, Hagley, Karlene, additional, Hakim, Alan J., additional, Hamuryudan, Vedat, additional, Haraoui, Boulos, additional, Harder, Adam, additional, Harley, John B., additional, Harris, E. Nigel, additional, Hashkes, Philip J., additional, Hawker, Gillian, additional, Hawkins, Philip N., additional, Heiberg, Turid, additional, Heinegård, Dick, additional, Helfgott, Simon M., additional, Heller, Jenny E., additional, Herrick, Ariane L., additional, Higgins, Laurence D., additional, Gaston, J. S. Hill, additional, Hochberg, Marc C., additional, Hoffmann, Markus, additional, Holers, V. Michael, additional, Holick, Michael F., additional, Holroyd, Christopher, additional, Hübscher, Osvaldo, additional, Huizinga, Tom W.J., additional, Hunter, David J., additional, Husni, M. Elaine, additional, Inman, Robert D., additional, Isaac, Zacharia, additional, Iversen, Maura D., additional, Jabs, Douglas A., additional, James, Hayley, additional, Javier, Rose-Marie, additional, Jayne, David, additional, Johnsen, Alyssa K., additional, Jordan, Joanne M., additional, Joy, Melanie S., additional, Kaisho, Tsuneyasu, additional, Kallenberg, Cees G.M., additional, Kanno, Yuka, additional, Karlson, Elizabeth W., additional, Kassimos, Dimitrios G., additional, Kastner, Daniel L., additional, Katz, Jeffrey N., additional, Kavanaugh, Arthur, additional, Kay, Jonathan, additional, Kelly, Jennifer A., additional, Keystone, Edward, additional, Khamashta, Munther A., additional, Khanna, Dinesh, additional, Kim, Peter W., additional, Kjeken, Ingvild, additional, Koch, Alisa E., additional, Koff, Matthew F., additional, Kraus, Virginia Byers, additional, Kremers, Hillal Maradit, additional, Krug, Hollis Elaine, additional, Kumar, Pradeep, additional, Kvien, Tore K., additional, Lafyatis, Robert, additional, Landau, Talia, additional, Landewé, Robert B.M., additional, Langford, Carol A., additional, Laxer, Ronald M., additional, Learch, Thomas J., additional, Leirisalo-Repo, Marjatta, additional, Lewith, George T., additional, Li, Yi, additional, Liao, Katherine P., additional, Littlejohn, Geoffrey, additional, Lockshin, Michael D., additional, Lorenzo, Pilar, additional, Luger, Thomas A., additional, Lundberg, Ingrid E., additional, Luthra, Harvinder S., additional, Machold, Klaus P., additional, Mackenzie, C. Ronald, additional, Mahowald, Maren Lawson, additional, Mahr, Alfred D., additional, Marini, Joan C., additional, Markalanda, Eresha, additional, Marquez, Javier, additional, Martel-Pelletier, Johanne, additional, Martin-Mola, Emilio, additional, Martinez-Lavin, Manuel, additional, Massarotti, Elena M., additional, Matteson, Eric L., additional, Mayes, Maureen, additional, Mayosi, Bongani M., additional, McAlindon, Timothy, additional, McCallum, Rex M., additional, McCarthy, Geraldine, additional, McCune, W. Joseph, additional, McGann, Stephany A., additional, McGonagle, Dennis, additional, McLean, Lachy, additional, Mease, Philip J., additional, Merkel, Peter A., additional, Mikdashi, Jamal A., additional, Miller, Frederick W., additional, Miller, Paul D., additional, Minden, Kirsten, additional, Mitsias, Dimitris I., additional, Mody, Girish M., additional, Monach, Paul A., additional, Moreland, Larry W., additional, Moutsopoulos, Haralampos M., additional, Namur, Gauthier, additional, Naredo, Esperanza, additional, Nashel, David J., additional, Nelson, Amanda E., additional, Newman, Stanton P., additional, Nossent, Johannes C., additional, Nöth, Ulrich, additional, O’Connor, Philip, additional, Oddis, Chester V., additional, Olsson, K. Sigvard, additional, Ombrello, Michael J., additional, Orcel, Philippe, additional, O'Shea, John J., additional, Paget, Stephen A., additional, Patrono, Carlo, additional, Pelletier, Jean-Pierre, additional, Pierangeli, Silvia, additional, Pierce, Heather, additional, Pilkington, Clarissa A., additional, Pillinger, Michael H., additional, Pineda, Carlos, additional, Plenge, Robert M., additional, Pricop, Luminita, additional, Rackwitz, Lars, additional, Ramani, Gautam, additional, Ravelli, Angelo, additional, Reeves, Westley H., additional, Remmers, Elaine F., additional, Repo, Heikki, additional, Requena, Luis, additional, Ribbens, Clio, additional, Riley, Graham, additional, Ritchlin, Christopher, additional, Rosas, Ivan O., additional, Roubenoff, Ronenn, additional, Rowan, A.D., additional, Rudwaleit, Martin, additional, Saag, Kenneth G., additional, Salmon, Jane E., additional, Salonen, David C., additional, Salter, Donald M., additional, Salzberg, Daniel J., additional, Sambrook, Philip N., additional, Sanofsky, Benjamin, additional, Saxne, Tore, additional, Schaible, Hans-Georg, additional, Schett, Georg, additional, Schmitz, Nicole, additional, Schon, Lew C., additional, Schumacher, H. Ralph, additional, Scott, David G.I., additional, Seidelmann, Brooke, additional, Sestak, Andrea L., additional, Seton, Margaret, additional, Shadick, Nancy A., additional, Shapiro, Lauren, additional, Shi, Lewis L., additional, Sidiropoulos, Prodromos, additional, Siegel, Richard M., additional, Sieper, Joachim, additional, Silver, Richard M., additional, Silverberg, Shonni J., additional, Simard, Julia F., additional, Simmons, Barry P., additional, Simms, Robert W., additional, Sims, John, additional, Singer, Nora G., additional, Smith, Malcolm D., additional, Smith, Stacy E., additional, Smolen, Josef S., additional, Spector, Tim D., additional, St. Clair, E. William, additional, Steen, Virginia D., additional, Steiner, Günter, additional, Steinert, Andre F., additional, Stone, John H., additional, Stone, Millicent A., additional, Straub, Rainer H., additional, Symmons, Deborah P.M., additional, Szekanecz, Zoltán, additional, Szer, Ilona S., additional, Tak, Paul P., additional, Tavoni, Antonio, additional, Taylor, Peter C., additional, Terkeltaub, Robert, additional, Thabet, Mohamed M., additional, Thorne, Jennifer E., additional, Tsokos, George C., additional, Tuan, Rocky S., additional, Turesson, Carl, additional, Tzioufas, Athanasios G., additional, Uber, Patricia A., additional, van den Berg, Wim B., additional, van der Heijde, Désirée, additional, van Gaalen, Floris A., additional, Varga, John, additional, Vassilopoulos, Dimitrios, additional, Vasudevan, Archana R., additional, Venables, Patrick J.W., additional, Vital, Edward M., additional, Wakefield, Richard J., additional, Walker, Jennifer G., additional, Ward, Robert J., additional, Watts, Richard, additional, Wedderburn, Lucy R., additional, Weinblatt, Michael E., additional, Weir, Matthew R., additional, Wenham, Claire Y.J., additional, West, Sterling G., additional, Weyand, Cornelia M., additional, White, Kenneth E., additional, Williams, Frances M.K., additional, Winthrop, Kevin L., additional, Woolf, Anthony D., additional, Worthington, Jane, additional, Wright, John, additional, Yazici, Hasan, additional, Yazici, Yusuf, additional, York, John R., additional, Young, D.A., additional, Yurdakul, Sebahattin, additional, Zhai, Guangju, additional, Zhang, Yuqing, additional, and Zhuang, Haoyang, additional

Published
2011
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40. Contributors

Author

Abelson, Abby G., Abraham, Mary, Abramson, Steven B., Adachi, Jonathan D., Aggarwal, Rohit, Akira, Shizuo, Aletaha, Daniel, Ashraf Ali, Amjid, Allem, Kavitta B., Almehthel, Mohammed, Almohaya, Mohammed, Riera Alonso, Elena, Amigo, Mary-Carmen, Aringer, Martin, Arkema, Elizabeth V., Ascherman, Dana P., Atamas, Sergei P., Atkinson, Timothy J., Azeez, Maha A., Baer, Alan N., Baraliakos, Xenofon, Bardin, Thomas, Barnsley, Leslie, Barr, Andrew J., Bathon, Joan M., Belch, Jill J.F., Bellido, Teresita, Ben-Artzi, Ami, Benedetti, Fabrizio, Bennell, Kim L., Bennett, Sarah E., Berard, Roberta A., Berenbaum, Francis, Berman, Brian, Bermas, Bonnie L., Elizabeth Berry, Alice, Bertsias, George, Bhana, Suleman, Bhattacharyya, Shamik, Bilginer, Yelda, Bleasel, Jane F., Block, Joel A., Böhm, Markus, Bonelli, Michael, Boumpas, Dimitrios T., Bozec, Aline, Brasington, Richard D., Braun, Jürgen, Brouwer, Elisabeth, Brown, Jacques P., Brown, Matthew A., Brown, Matthew L., Buch, Maya H., Buckley, Christopher D., Bugbee, William D., Burmester, Gerd-Rüdiger, Burns, Jane C., Burr, David B., Buttgereit, Frank, Buxbaum, Joel N., Bykerk, Vivian P., Calabrese, Cassandra, Calabrese, Leonard H., Callen, Jeffrey P., Carr, Andrew J., Carrino, John A., Cavallo, Sabrina, Cervera, Ricard, Chang, Christopher, Chang, Joyce C., Chaon, Benjamin C., Chaudhary, Prateek, Choi, Hyon K., Choy, Ernest H.S., Christopher-Stine, Lisa, Chung, Lorinda, Ciccia, Francesco, Clauw, Daniel J., Clinch, Jacqui, Clowse, Megan E.B., Coghlan, John (Gerry), Colbert, Robert A., Conaghan, Philip G., Cooper, Cyrus, Costello, Wendy, Costenbader, Karen H., Cox, George L.D., Creamer, Paul, Cronstein, Bruce N., Cross, Raymond K., Curtis, Jeffrey R., D'Adamo, Chris, D'Agati, Vivette D., Daikh, David I., Dakin, Stephanie G., Dalbeth, Nicola, Davis, Aileen M., D'Cruz, David P., Eduardo de Barros Branco, Carlos, de Boer, Berber, De Craemer, Ann-Sophie, de Jesus, Adriana A., De Vita, Salvatore, de Wit, Maarten, Deal, Chad L., Deane, Kevin D., Dellaripa, Paul F., Dennison, Elaine, Denton, Christopher P., DiCarlo, Edward F., Distler, Oliver, Donlan, Pamela, Doyle, Tracy J., du Preez, Hannah, Dyer, George S.M., Eastell, Richard, Ehrchen, Jan, Elewaut, Dirk, Emery, Paul, Emmerling, Max R., Espinosa, Gerard, Espinoza, Luis R., Eyre, Stephen, Fanouriakis, Antonis, Farber, Joshua, Fasth, Anders, Feist, Eugen, Feldman, Candace H., Fernandez-Ruiz, Ruth, Filer, Andrew, Fiorentino, David F., Fisher, Benjamin A., Fisk, John D., Flajnik, Martin F., Forbess, Lindsy, Fox, David A., Frech, Tracy M., Frisaldi, Elisa, Gabay, Cem, Gadina, Massimo, Gandolfo, Saviana, Garelick, Daniela, Gay, Steffen, Geifman, Nophar, George, Michael D., Eric Gershwin, M., Ghadiali, Jay, Gilis, Elisabeth, Gold, Deborah T., Gold, Garry E., Goldbach-Mansky, Raphaela, Gómez-Puerta, José A., Goodman, Susan M., Gordon, Caroline, Gordon, Sharon, Gossec, Laure, Grainger, Andrew J., Grainger, Rebecca, Gravallese, Ellen M., Greenberg, Jeffrey D., Guglielmi, Luiza Guilherme, Gül, Ahmet, Gullapalli, Rao P., Guma, Monica, Gupta, Sarthak, Han, Shuhong, Hanly, John G., Hanson, Eric P., Haraoui, Boulos, Harley, John B., Haroun, Tayseer G., Hashkes, Philip J., Hasni, Sarfaraz A., Bassim Hassan, Andrew, Haupt, Lukas, Hausmann, Jonathan S., Hawker, Gillian A., Heiberg, Turid, Helfgott, Simon M., Hinman, Rana S., Hoffmann-Vold, Anna-Maria, Holroyd, Christopher R., Holt, Cathy, Horomanski, Audra, Huizinga, Thomas W.J., Humby, Frances, Elaine Husni, M., Hwang, Jonathan, Hyrich, Kimme, Inman, Robert D., Inoue, Dai, Isaac, Zacharia, Isaacs, John D., Isenberg, David, Iversen, Maura D., Jabs, Douglas A., James, Judith A., Jandali, Bochra, Kassim Javaid, M., Javier, Rose-Marie, Jefferis, Roy, Jeffries, Matlock A., Johnson, Sindhu R., Johnstone, Brian, Helena Jonsson, Anna, Joyce, Andrew A., Jung, Michelle, Kado, Ruba, Kaisho, Tsuneyasu, Kamal, Natasha, Kane, David, Kaplan, Mariana J., Karr, Timothy L., Kassimos, Dimitrios G., Kastner, Daniel L., Katz, Jeffrey N., Kawano, Mitsuhiro, Kay, Jonathan, Keating, Richard M., Kelly, Jennifer A., Kendler, David, Keyser, Randall E., Khamashta, Munther A., Khanna, Dinesh, Khokhar, Kiran, Kiefer, David, King, Lauren K., Kloppenburg, Margreet, Kolasinski, Sharon L., Kolstad, Kathleen D., Kottyan, Leah C., Byers Kraus, Virginia, Kronberger, Leo R.W., Kroopnick, Jeffrey M., Kvien, Tore K., LaBaer, Joshua, Lafyatis, Robert, Lakkis, Jay I., Landewé, Robert B.M., Langford, Carol A., Laster, Marciana L., Latourte, Augustin, Lau, Arthur N., Laurynenka, Viktoryia, Lavin, Robert A., Laxer, Ronald M., Li, Suzanne C., Liao, Katherine P., Lieberman, Scott M., Liew, Jean W., Littlejohn, Geoffrey O., Liu, Eva S., Lo, Lawrence, Lories, Rik J., Luger, Thomas A., Lundberg, Ingrid E., Luqmani, Raashid A., Machado, Pedro M., Machold, Klaus P., Ronald MacKenzie, C., Major, Tanya J., Malfait, Anne-Marie, Malley, Tamir, Manasson, Julia, March, Lyn M., Olivé Marqués, Alejandro, Márquez, Javier, Martin, Paul, Martínez-Lavín, Manuel, Matteson, Eric L., Mayes, Maureen D., McAlindon, Timothy, McCarthy, Edward F., McCarthy, Geraldine M., McDermott, Michael F., McDonnell, Patrick J., McGonagle, Dennis, Simon Meara, Alexa, Mehta, Jay J., Melville, Andrew R., Merola, Joseph F., Micheletti, Robert G., Michou, Laëtitia, Middleton, Rob, Midha, Disha, Mikdashi, Jamal A., Miller, Frederick W., Minden, Kirsten, Miner, Jonathan J., Minhas, Deeba, Helene Moe, Rikke, Möller, Ingrid, Mopuru, Renuka, Mortaji, Parisa, Mueller, Alisa A., Myasoedova, Elena, Namur, Gauthier, Naredo, Esperanza, Navarro-Compán, Victoria, Neerinckx, Barbara, Nelson, Amanda E., Nerviani, Alessandra, Nicolson, Philippa J.A., Nordal, Ellen B., Nöth, Ulrich, Ntatsaki, Eleana, Obenhuber, Tilman, Oddis, Chester V., Ogdie-Beatty, Alexis R., Omar, Ahmed, Ombrello, Michael J., Omisade, Antonina, Onel, Karen B., Ong, Voon H., Orcel, Philippe, Orozco, Gisela, Orr, Carl, O'Shea, John J., Ospelt, Caroline, Østensen, Monika, Özen, Seza, Park, Elizabeth, Parker, Matthew J.S., Pathan, Ejaz, Patrono, Carlo, Perez-Chada, Lourdes M., Pijnenburg, Luc, Pillinger, Michael H., Pineda, Carlos, Pipitone, Nicolò, Pitzalis, Costantino, Poddubnyy, Denis, Pope, Janet E., Postolova, Anna, Price, Andrew J., Pryor, Katherine P., Quartuccio, Luca, Rackwitz, Lars, Radner, Helga, Rajendran, Aardra, Ramiro, Sofia, Raychaudhuri, Soumya, Redmond, Anthony C., Reeves, Westley H., Remmers, Elaine F., Requena, Luis, Reynolds, Gary, Reynolds, John A., Ribbens, Clio, Richards, Bethan, Richardson, Bruce, Richette, Pascal, Ritchlin, Christopher T., Ritter, Susan Y., Robinson, Philip C., Robinson, William H., Rogers, Valerie J., Romain, Paul L., Rosas, Ivan O., Rosenthal, Ann K., Rubin, Elka, Rudwaleit, Martin, Rutgers, Bram A., Rygg, Marite, Saag, Kenneth G., Salmon, Jane E., Salusky, Isidro B., Salvarani, Carlo, Sandell, Linda J., Sandhu, Vaneet K., Sandovici, Maria, Sand-Svartrud, Anne-Lene, Scanzello, Carla R., Schaible, Hans-Georg, Scher, Jose U., Schett, Georg, Schiffenbauer, Adam I., Schiller, Alan L., Schlesinger, Naomi, Schreiber, Benjamin E., Schwartz, Daniella M., Shaibani, Aziz, Sharma, Leena, Shmerling, Robert H., Siaton, Bernadette C., Siegel, Richard M., Sieghart, Daniela, Silverman, Stuart L., Simard, Julia F., Simmons, Barry P., Simms, Robert W., Singer, Nora G., Sirotich, Emily, Smith, Judith A., Smith, Stacy E., Smolen, Josef S., Solomon, Daniel H., Sparks, Jeffrey A., Stack, John, Stanley, David, Steen, Virginia D., Steere, Allen C., Stegeman, Coen A., Steiner, Günter, Steinert, Andre F., Stojan, George, Strand, Vibeke, Sufka, Paul, Sullivan, James K., Szulc, Pawel, Tang, Chen, Tang, Shiyu, Taylor, Peter C., Terkeltaub, Robert, Thomas, Afton R., Thorne, Jennifer E., Topping, Louise M., Toprover, Michael, Torralba, Karina, Touma, Zahi, Tremoulet, Adriana H., Trouw, Leendert, Tuan, Rocky S., Uçkay, Ilker, Umehara, Hisanori, van der Geest, Kornelis S.M., van der Heijde, Désirée, van Gaalen, Floris A., Van Mechelen, Margot, van Vollenhoven, Ronald F., Vandevelde, Claire Y.J., Varga, John, Vassilopoulos, Dimitrios, Veale, Douglas J., Verstappen, Gwenny M., Viatte, Sebastien, Vincent, Tonia L., Vital, Edward M., von Loga, Isabell S., Wahezi, Dawn M., Wallace, Daniel J., Wallace, Zachary S., Warburton, Gary, Watad, Abdulla, Watts, Richard A., Weinblatt, Michael E., Weir, Matthew R., Weisman, Michael H., Weiss, Pamela F., Branford White, Harriet, White, Kenneth E., Wilkinson, David J., Williams, David E., Williams, Richard, Wilson, Hannah, Winthrop, Kevin L., Witt, Claudia M., Witzmann, Gerhard, Wong, John B., Woolf, Anthony D., Paul Wordsworth, B., Xu, Huji, Yazdany, Jinoos, Young, David A., Young, Stephen P., Md Yusof, Md Yuzaiful, and Zhuang, Haoyang

Published
2023
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42. Abatacept in Early Diffuse Cutaneous Systemic Sclerosis - Results of a Phase 2 Investigator-Initiated, Multicenter, Double-Blind Randomized Placebo-Controlled Trial

Author

Khanna, Dinesh, Spino, Cathie, Johnson, Sindhu, Chung, Lorinda, Whitfield, Michael L, Denton, Christopher P, Berrocal, Veronica, Franks, Jennifer, Mehta, Bhaven, Molitor, Jerry, Steen, Virginia D, Lafyatis, Robert, Simms, Robert W, Gill, Anna, Kafaja, Suzanne, Frech, Tracy M, Hsu, Vivien, Domsic, Robyn T, Pope, Janet E, Gordon, Jessica K, Mayes, Maureen D, Schiopu, Elena, Young, Amber, Sandorfi, Nora, Park, Jane, Hant, Faye N, Bernstein, Elana J, Chatterjee, Soumya, Castelino, Flavia V, Ajam, Ali, Wang, Yue, Wood, Tammara, Allanore, Yannick, Matucci-Cerinic, Marco, Distler, Oliver, Singer, Ora, Bush, Erica, Fox, David A, Furst, Daniel E, University of Zurich, and Khanna, Dinesh

Subjects
2403 Immunology, 2745 Rheumatology, 10051 Rheumatology Clinic and Institute of Physical Medicine, 2723 Immunology and Allergy, 610 Medicine & health
Published
2020
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43. A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Oral Type I Collagen Treatment in Patients With Diffuse Cutaneous Systemic Sclerosis: I. Oral Type I Collagen Does Not Improve Skin in All Patients, But May Improve Skin in Late-Phase Disease

Author

Postlethwaite, Arnold E., Wong, Weng Kee, Clements, Philip, Chatterjee, Soumya, Fessler, Barri J., Kang, Andrew H., Korn, Joseph, Mayes, Maureen, Merkel, Peter A., Molitor, Jerry A., Moreland, Larry, Rothfield, Naomi, Simms, Robert W., Smith, Edwin A., Spiera, Robert, Steen, Virginia, Warrington, Kenneth, White, Barbara, Wigley, Frederick, and Furst, Daniel E.

Published
2008

44. A 64-year-man with cranial-nerve palsies and a positive test for antinuclear cytoplasmic antibodies

Author

Simms, Robert W. and Kirby, Robin E.

Subjects
Wegener's granulomatosis -- Diagnosis
Abstract

A 64-year-old man was admitted to a hospital with chronic sinusitis and headache, facial weakness and hearing loss on the right side of his head. CT scans of his head showed destruction of the right temporal bone, which makes up the temples. Tests of blood and cerebrospinal samples revealed no evidence of bacterial or fungal infection. His physicians suspected some type of vasculitis, which is an inflammation of blood vessels. He had tested positive for antineutrophil cytoplasmic antibodies (ANCA), which is characteristic of these disorders. A biopsy of his facial sinuses revealed that he had a type of vasculitis called Wegener's granulomatosis.

Published
1998

46. Scleroderma Lung Study (SLS): differences in the presentation and course of patients with limited versus diffuse systemic sclerosis

Author

Clements, Philip J., Roth, Michael D., Elashoff, Robert, Tashkin, Donald P., Goldin, Jonathan, Silver, Richard M., Sterz, Mildred, Seibold, James R., Schraufnagel, Dean, Simms, Robert W., Bolster, Marcy, Wise, Robert A., Steen, Virginia, Mayes, M.D., Connelly, Kari, Metersky, Mark, and Furst, Daniel E.

Subjects
Scleroderma (Disease) -- Development and progression, Scleroderma (Disease) -- Physiological aspects, Scleroderma (Disease) -- Comparative analysis, Systemic scleroderma -- Development and progression, Systemic scleroderma -- Physiological aspects, Systemic scleroderma -- Comparative analysis, Pulmonary fibrosis -- Care and treatment, Pulmonary fibrosis -- Development and progression, Health
Published
2007

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