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1. Isolation of Diverse Simian Arteriviruses Causing Hemorrhagic Disease

Author

Shaw, Teressa M., Dettle, Samuel T., Mejia, Andres, Hayes, Jennifer M., Simmons, Heather A., Basu, Puja, Kuhn, Jens H., Ramuta, Mitchell D., Warren, Cody J., Jahrling, Peter B., O'Connor, David H., Huang, Liupei, Zaeem, Misbah, Seo, Jiwon, Slukvin, Igor I., Brown, Matthew E., and Bailey, Adam L.

Subjects
United States. National Institutes of Health, Hemorrhagic fever, Ethylenediaminetetraacetic acid, Hematopoietic stem cells, Macrophages, Health, University of Wisconsin-Madison. Wisconsin National Primate Research Center
Abstract

Simarteriviruses (order Nidovirales, family Arteriviridae, subfamily Simarterivirinae) are genetically diverse viruses that naturally infect cercopithecoid monkeys throughout sub-Saharan Africa. Many divergent simarteriviruses can infect macaques, although severity of disease ranges [...]

Published
2024
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5. Early Embryonic Loss Following Intravaginal Zika Virus Challenge in Rhesus Macaques.

Author

Newman, Christina M, Tarantal, Alice F, Martinez, Michele L, Simmons, Heather A, Morgan, Terry K, Zeng, Xiankun, Rosinski, Jenna R, Bliss, Mason I, Bohm, Ellie K, Dudley, Dawn M, Aliota, Matthew T, Friedrich, Thomas C, Miller, Christopher J, and O'Connor, David H

Subjects
Zika virus, embryonic loss, intravaginal infection, macaques, pregnancy, Immunology, Medical Microbiology
Abstract

Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) and is primarily transmitted by Aedes species mosquitoes; however, ZIKV can also be sexually transmitted. During the initial epidemic and in places where ZIKV is now considered endemic, it is difficult to disentangle the risks and contributions of sexual versus vector-borne transmission to adverse pregnancy outcomes. To examine the potential impact of sexual transmission of ZIKV on pregnancy outcome, we challenged three rhesus macaques (Macaca mulatta) three times intravaginally with 1 x 107 PFU of a low passage, African lineage ZIKV isolate (ZIKV-DAK) in the first trimester (~30 days gestational age). Samples were collected from all animals initially on days 3 through 10 post challenge, followed by twice, and then once weekly sample collection; ultrasound examinations were performed every 3-4 days then weekly as pregnancies progressed. All three dams had ZIKV RNA detectable in plasma on day 3 post-ZIKV challenge. At approximately 45 days gestation (17-18 days post-challenge), two of the three dams were found with nonviable embryos by ultrasound. Viral RNA was detected in recovered tissues and at the maternal-fetal interface (MFI) in both cases. The remaining viable pregnancy proceeded to near term (~155 days gestational age) and ZIKV RNA was detected at the MFI but not in fetal tissues. These results suggest that sexual transmission of ZIKV may represent an underappreciated risk of pregnancy loss during early gestation.

Published
2021

6. Combined Treatment of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes and Endothelial Cells Regenerate the Infarcted Heart in Mice and Non-Human Primates

Author

Cheng, Yu-Che, Hsieh, Marvin L., Lin, Chen-Ju, Chang, Cindy M.C., Huang, Ching-Ying, Puntney, Riley, Wu Moy, Amy, Ting, Chien-Yu, Herr Chan, Darien Zhing, Nicholson, Martin W., Lin, Po-Ju, Chen, Hung-Chih, Kim, Gina C., Zhang, Jianhua, Coonen, Jennifer, Basu, Puja, Simmons, Heather A., Liu, Yen-Wen, Hacker, Timothy A., Kamp, Timothy J., and Hsieh, Patrick C.H.

Published
2023
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7. Development of a Geropathology Grading Platform for nonhuman primates

Author

Olstad, Katie J, Imai, Denise M, Keesler, Rebekah I, Reader, Rachel, Morrison, John H, Roberts, Jeffery A, Capitanio, John P, Didier, Elizabeth S, Kuroda, Marcelo J, Simmons, Heather, Salimi, Shabnam, Mattison, Julie A, Ikeno, Yuji, and Ladiges, Warren

Subjects
Archaeology, History, Heritage and Archaeology, Psychology, Aging, Good Health and Well Being, age-related diseases, geropathology, geroscience, marmosets, mice, nonhuman primates, rhesus macaques
Abstract

A geropathology grading platform (GGP) for assessing age-related lesions has been established and validated for in inbred strain of mice. Because nonhuman primates (NHPs) share significant similarities in aging and spontaneous chronic diseases with humans, they provide excellent translational value for correlating histopathology with biological and pathological events associated with increasing age. Descriptive age-associated pathology has been described for rhesus macaques and marmosets, but a grading platform similar to the mouse GGP does not exist. The value of these NHP models is enhanced by considerable historical data from clinical, bio-behavioral, and social domains that align with health span in these animals. Successful adaptation of the mouse GGP for NHPs will include 1) expanding the range of organs examined; 2) standardizing necropsy collection, tissue trimming, and descriptive lesion terminology; 3) expanding beyond rhesus macaques and marmosets to include other commonly used NHPs in research; and 4) creating a national resource for age-related pathology to complement the extensive in-life datasets. Adaptation of the GGP to include translational models other than mice will be crucial to advance geropathology designed to enhance aging research.

Published
2020

8. Sequestration and Destruction of Rinderpest Virus--Containing Material 10 Years after Eradication

Author

Budke, Christine M., Pfeiffer, Dirk U., Jones, Bryony A., Fournie, Guillaume, Kim, Younjung, Marrana, Mariana, and Simmons, Heather L.

Subjects
Epidemics -- Control -- United States, Hazardous substances -- Waste management, Medical wastes -- Waste management, Rinderpest -- Control, Health
Abstract

In 2011, ten years after the last confirmed outbreak, the Food and Agriculture Organization of the United Nations (FAO) and the World Organisation for Animal Health (WOAH, formerly OIE) jointly [...]

Published
2022
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9. Efficient in vivo neuronal genome editing in the mouse brain using nanocapsules containing CRISPR-Cas9 ribonucleoproteins

Author

Metzger, Jeanette M., Wang, Yuyuan, Neuman, Samuel S., Snow, Kathy J., Murray, Stephen A., Lutz, Cathleen M., Bondarenko, Viktoriya, Felton, Jesi, Gimse, Kirstan, Xie, Ruosen, Li, Dongdong, Zhao, Yi, Flowers, Matthew T., Simmons, Heather A., Roy, Subhojit, Saha, Krishanu, Levine, Jon E., Emborg, Marina E., and Gong, Shaoqin

Published
2023
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12. Metabolism in the Midwest: research from the Midwest Aging Consortium at the 49th Annual Meeting of the American Aging Association

Author

Murphy, Michaela E., Narasimhan, Akilavalli, Adrian, Alexis, Kumar, Ankur, Green, Cara L., Soto-Palma, Carolina, Henpita, Chathurika, Camell, Christina, Morrow, Christopher S., Yeh, Chung-Yang, Richardson, Claire E., Hill, Cristal M., Moore, Darcie L., Lamming, Dudley W., McGregor, Eric R., Simmons, Heather A., Pak, Heidi H., Bai, Hua, Denu, John M., Clark, Josef, Simcox, Judith, Chittimalli, Kishore, Dahlquist, Korbyn, Lee, Kyoo-a, Calubag, Mariah, Bouska, Mark, Yousefzadeh, Matthew J., Sonsalla, Michelle, Babygirija, Reji, Yuan, Rong, Tsuji, Tadataka, Rhoads, Timothy, Menon, Vinal, Jarajapu, Yagna PR., and Zhu, Yun

Published
2022
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13. Enhancing Faculty Productivity through a Centralized Communications and Project Management Infrastructure: A Case Study at the University of Kentucky Markey Cancer Center

Author

Russell-Simmons, Heather N., Anthony, Cathy, Ballard, Marcia, Coffman, Jonathan, Gilbreath, Donna, Keys, Terry L., Story, Danielle, Rogers, Jennifer, Gosky, David M., and Vanderford, Nathan L.

Abstract

Academic careers and institutional reputations are closely linked with the ability to secure funding and publish work. In today's competitive environment, it is essential for research to be clearly communicated. In our experience, many researchers need assistance with communication skills, and institutions that offer professional services in grant, manuscript and project management have an advantage in the development of their faculty and trainees. A review of the literature shows that some institutions offer centralized proposal development resources and personnel to assist with grant writing, some institutions offer workshops and lectures designed to improve researchers' writing skills for grants and/or manuscripts, and fewer institutions offer departments focused specifically on editing manuscripts. In the fall of 2009, the University of Kentucky's (UK) Markey Cancer Center (MCC) developed an infrastructure, the Research Communications Office (RCO), to enhance faculty productivity. The RCO exists to provide: expertise in scientific editing of manuscripts for academic publishing; editing and management of research, training, and career development grants; project management for multi-component and institutionally complex grants; facilitation and tracking of all MCC pilot funding mechanisms; tracking all research outcomes; preparation of graphics for presentations, posters, publications and grants; marketing and design expertise for outreach endeavors; the planning and execution of internal and external communications; and MCC web content creation and maintenance. A successful and valued service for MCC, the RCO has totaled more than 1,400 projects over six years, growing from 189 projects when tracking began in 2010 to 294 in 2015. This article will discuss why and how the RCO was created at the MCC, and in doing so, provide a framework for how the RCO model can be successfully implemented at other institutions interested in offering professional editing and management of grants and manuscripts.

Published
2016

14. Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates.

Author

Dudley, Dawn M, Van Rompay, Koen K, Coffey, Lark L, Ardeshir, Amir, Keesler, Rebekah I, Bliss-Moreau, Eliza, Grigsby, Peta L, Steinbach, Rosemary J, Hirsch, Alec J, MacAllister, Rhonda P, Pecoraro, Heidi L, Colgin, Lois M, Hodge, Travis, Streblow, Daniel N, Tardif, Suzette, Patterson, Jean L, Tamhankar, Manasi, Seferovic, Maxim, Aagaard, Kjersti M, Martín, Claudia Sánchez-San, Chiu, Charles Y, Panganiban, Antonito T, Veazey, Ronald S, Wang, Xiaolei, Maness, Nicholas J, Gilbert, Margaret H, Bohm, Rudolf P, Adams Waldorf, Kristina M, Gale, Michael, Rajagopal, Lakshmi, Hotchkiss, Charlotte E, Mohr, Emma L, Capuano, Saverio V, Simmons, Heather A, Mejia, Andres, Friedrich, Thomas C, Golos, Thaddeus G, and O'Connor, David H

Subjects
Animals, Primates, Abortion, Spontaneous, Pregnancy, Female, Male, Stillbirth, Kaplan-Meier Estimate, Zika Virus, Zika Virus Infection, Abortion, Spontaneous, Immunology, Medical and Health Sciences
Abstract

Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here, we found that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite showing few clinical signs of infection. Pregnancy loss due to asymptomatic ZIKV infection may therefore be a common but under-recognized adverse outcome related to maternal ZIKV infection.

Published
2018

15. Cotyledon‐Specific Flow Evaluation of Rhesus Macaque Placental Injury Using Ferumoxytol Dynamic Contrast‐Enhanced MRI

Author

Chen, Ruiming, primary, Seiter, Daniel, additional, Keding, Logan T., additional, Vazquez, Jessica, additional, Antony, Kathleen M., additional, Simmons, Heather A., additional, Basu, Puja, additional, Mejia, Andres F., additional, Johnson, Kevin M., additional, Stanic, Aleksandar K., additional, Liu, Ruo‐Yu, additional, Shah, Dinesh M., additional, Golos, Thaddeus G., additional, and Wieben, Oliver, additional

Published
2024
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18. Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques.

Author

Nguyen, Sydney M, Antony, Kathleen M, Dudley, Dawn M, Kohn, Sarah, Simmons, Heather A, Wolfe, Bryce, Salamat, M Shahriar, Teixeira, Leandro BC, Wiepz, Gregory J, Thoong, Troy H, Aliota, Matthew T, Weiler, Andrea M, Barry, Gabrielle L, Weisgrau, Kim L, Vosler, Logan J, Mohns, Mariel S, Breitbach, Meghan E, Stewart, Laurel M, Rasheed, Mustafa N, Newman, Christina M, Graham, Michael E, Wieben, Oliver E, Turski, Patrick A, Johnson, Kevin M, Post, Jennifer, Hayes, Jennifer M, Schultz-Darken, Nancy, Schotzko, Michele L, Eudailey, Josh A, Permar, Sallie R, Rakasz, Eva G, Mohr, Emma L, Capuano, Saverio, Tarantal, Alice F, Osorio, Jorge E, O'Connor, Shelby L, Friedrich, Thomas C, O'Connor, David H, and Golos, Thaddeus G

Subjects
Lung, Decidua, Spleen, Amniotic Fluid, Umbilical Cord, Fetus, Placenta, Animals, Macaca mulatta, Humans, Pregnancy Complications, Infectious, Viremia, Disease Models, Animal, RNA, Viral, Fetal Development, Pregnancy, Female, Infectious Disease Transmission, Vertical, Zika Virus, Zika Virus Infection, Disease Models, Animal, Infectious Disease Transmission, Vertical, Pregnancy Complications, Infectious, RNA, Viral, Virology, Microbiology, Immunology, Medical Microbiology
Abstract

Infection with Zika virus (ZIKV) is associated with human congenital fetal anomalies. To model fetal outcomes in nonhuman primates, we administered Asian-lineage ZIKV subcutaneously to four pregnant rhesus macaques. While non-pregnant animals in a previous study contemporary with the current report clear viremia within 10-12 days, maternal viremia was prolonged in 3 of 4 pregnancies. Fetal head growth velocity in the last month of gestation determined by ultrasound assessment of head circumference was decreased in comparison with biparietal diameter and femur length within each fetus, both within normal range. ZIKV RNA was detected in tissues from all four fetuses at term cesarean section. In all pregnancies, neutrophilic infiltration was present at the maternal-fetal interface (decidua, placenta, fetal membranes), in various fetal tissues, and in fetal retina, choroid, and optic nerve (first trimester infection only). Consistent vertical transmission in this primate model may provide a platform to assess risk factors and test therapeutic interventions for interruption of fetal infection. The results may also suggest that maternal-fetal ZIKV transmission in human pregnancy may be more frequent than currently appreciated.

Published
2017

21. Developing One Health capacity and networks through virtual training

Author

Arevalo, Maria de la Puente, primary, Maud, Jenny, additional, Alviti, Alessandra, additional, Tang, Hao, additional, George, Acty, additional, Simmons, Heather, additional, Castellan, David, additional, Siriaroonrat, Boripat, additional, Neill, Eimear O, additional, Longchar, Achila, additional, Nova, Rodrigo J., additional, Chikurunhe, Wilmot, additional, Obonyo, Mark, additional, Newman, Scott, additional, Dhingra, Madhur, additional, and Sumption, Keith, additional

Published
2023
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23. Nanoparticle-mediated delivery of insulin-like growth factor 1 to the placenta in the non-human primate is safe and regulates placental signaling

Author

Wilson, Rebecca L., primary, Schmidt, Jenna Kropp, additional, Ren, Emily, additional, Keding, Logan T., additional, Shaw, Sarah A., additional, Heselton, Avery R., additional, Schotzko, Michele L., additional, Antony, Kathleen M., additional, Fitz, Casey, additional, Simmons, Heather A., additional, Basu, Puja, additional, Golos, Thaddeus G., additional, and Jones, Helen N., additional

Published
2023
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25. Vertical transmission of African-lineage Zika virus through the fetal membranes in a rhesus macaque (Macaca mulatta) model

Author

Koenig, Michelle R., primary, Mitzey, Ann M., additional, Zeng, Xiankun, additional, Reyes, Leticia, additional, Simmons, Heather A., additional, Morgan, Terry K., additional, Bohm, Ellie K., additional, Pritchard, Julia C., additional, Schmidt, Jenna A., additional, Ren, Emily, additional, Leyva Jaimes, Fernanda B., additional, Winston, Eva, additional, Basu, Puja, additional, Weiler, Andrea M., additional, Friedrich, Thomas C., additional, Aliota, Matthew T., additional, Mohr, Emma L., additional, and Golos, Thaddeus G., additional

Published
2023
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28. Infection of the maternal-fetal interface and vertical transmission following low-dose inoculation of pregnant rhesus macaques (Macaca mulatta) with an African-lineage Zika virus

Author

Koenig, Michelle R., primary, Mitzey, Ann M., additional, Morgan, Terry K., additional, Zeng, Xiankun, additional, Simmons, Heather A., additional, Mejia, Andres, additional, Leyva Jaimes, Fernanda, additional, Keding, Logan T., additional, Crooks, Chelsea M., additional, Weiler, Andrea M., additional, Bohm, Ellie K., additional, Aliota, Matthew T., additional, Friedrich, Thomas C., additional, Mohr, Emma L., additional, and Golos, Thaddeus G., additional

Published
2023
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29. Fetal Tissues Reflect Decidual-Placental Inflammation

Author

Vazquez, Jessica, primary, Keding, Logan, additional, Koenig, Michelle R, additional, Schotzko, Michele, additional, Antony, Kathleen, additional, Racine, Jenna, additional, Simmons, Heather A, additional, Shah, Dinesh M, additional, Wieben, Oliver, additional, and Golos, Thaddeus, additional

Published
2023
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31. Combined Treatment of Human Induced Pluripotent Stem Cell--Derived Cardiomyocytes and Endothelial Cells Regenerate the Infarcted Heart in Mice and Non-Human Primates.

Author

Yu-Che Cheng, Hsieh, Marvin L., Chen-Ju Lin, Chang, Cindy M. C., Ching-Ying Huang, Puntney, Riley, Wu Moy, Amy, Chien-Yu Ting, Zhing Herr Chan, Darien, Nicholson, Martin W., Po-Ju Lin, Hung-Chih Chen, Kim, Gina C., Jianhua Zhang, Coonen, Jennifer, Puja Basu, Simmons, Heather A., Yen-Wen Liu, Hacker, Timothy A., and Kamp, Timothy J.

Published
2023
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32. List of Reviewers

Author

Ange-Van Heugten, Kimberly, primary, Bales, Karen, additional, Capuano, Saverio, additional, Carlson, Cathy, additional, Colman, Ricki, additional, Doxiadis, Gaby, additional, Elmore, David, additional, Flecknell, Paul, additional, Garber, Paul, additional, Hart, Bert't, additional, Hoggatt, Amber, additional, Kaas, Jon, additional, Kramer, Joshua, additional, Leblanc, Mathias, additional, Lever, Steve, additional, Maginnis, Gwendalyn, additional, Makaron, Leah, additional, Mejia, Andres, additional, Miller, Andrew, additional, Mulder, Guy B., additional, Okumura, Atsushi, additional, de Paula Faria, Daniele, additional, Phillips, Kimberley, additional, Pryce, Christopher, additional, Remington, Evan, additional, Ross, Corinna, additional, Sahota, Pritam, additional, Schmidt, Jenna Kropp, additional, Schultz-Darken, Nancy, additional, Shenton, Jacintha, additional, Simmons, Heather, additional, Turcotte, Cassandra, additional, Westmoreland, Susan, additional, and Woodward, Ruth, additional

Published
2019
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33. Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus

Author

Rosinski, Jenna R., primary, Raasch, Lauren E., additional, Barros Tiburcio, Patrick, additional, Breitbach, Meghan E., additional, Shepherd, Phoenix M., additional, Yamamoto, Keisuke, additional, Razo, Elaina, additional, Krabbe, Nicholas P., additional, Bliss, Mason I., additional, Richardson, Alexander D., additional, Einwalter, Morgan A., additional, Weiler, Andrea M., additional, Sneed, Emily L., additional, Fuchs, Kerri B., additional, Zeng, Xiankun, additional, Noguchi, Kevin K., additional, Morgan, Terry K., additional, Alberts, Alexandra J., additional, Antony, Kathleen M., additional, Kabakov, Sabrina, additional, Ausderau, Karla K., additional, Bohm, Ellie K., additional, Pritchard, Julia C., additional, Spanton, Rachel V., additional, Ver Hoove, James N., additional, Kim, Charlene B. Y., additional, Nork, T. Michael, additional, Katz, Alex W., additional, Rasmussen, Carol A., additional, Hartman, Amy, additional, Mejia, Andres, additional, Basu, Puja, additional, Simmons, Heather A., additional, Eickhoff, Jens C., additional, Friedrich, Thomas C., additional, Aliota, Matthew T., additional, Mohr, Emma L., additional, Dudley, Dawn M., additional, O’Connor, David H., additional, and Newman, Christina M., additional

Published
2023
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37. Sarcinasp. as a presumptive cause of fatal acute gastric dilation and gastric emphysema in rhesus macaques

Author

Lee, Laura M., Owens, Leah A., Krugner-Higby, Lisa A., Graham, Melissa, Simmons, Heather A., Climans, Megan, Brown, Kelsey, Bennett, Allyson J., Schaefer, Jennifer, Meyer, Kyle, and Goldberg, Tony L.

Abstract

A 4-y-old female and 3-y-old male rhesus macaque (Macaca mulatta), both housed in the same facility, died unexpectedly within 2 wk. Postmortem examination revealed severe gastric dilation in both macaques and gastric emphysema in the female macaque. Histologically, bacteria consistent with Sarcinasp. were present in both macaques within the lungs and lumen of the trachea, esophagus, and gastrointestinal (GI) tract without associated inflammation. Additionally, in the female macaque, the bacteria were found in the gastric mucosa and associated with emphysematous spaces in the gastric wall without associated inflammation. PCR and Sanger sequencing of amplicons were subsequently performed on GI contents and non-alimentary tissues from the 2 affected monkeys and on comparative samples from unaffected rhesus monkeys in the same facility and an adjacent primate facility. The cases were compared using the 2-tailed Fisher exact test (p-value at 95% confidence). PCR identified Sarcinain GI contents of both affected and unaffected monkeys (p= 0.6084) and in non-alimentary tissues of affected monkeys only (p= 0.0083). These results suggest that the presence of Sarcinasp. in non-alimentary tissues is associated with gastric distension, gas accumulation, and unexpected death in nonhuman primates.

Published
2023
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38. Listeria monocytogenesinfection in pregnant macaques alters the maternal gut microbiome†

Author

Hugon, Anna Marie, Deblois, Courtney L, Simmons, Heather A, Mejia, Andres, Schotzo, Michele L, Czuprynski, Charles J, Suen, Garret, and Golos, Thaddeus G

Abstract

Intestinal microbial composition in macaques is influenced by interaction between the pregnant state and exposure to Listeria monocytogenes, associated in particular with significant changes to Akkermansia, Eubacterium ruminantium, Methanobrevibacter, Prevotella, and Treponema.Graphical Abstract

Published
2023
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39. Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus

Author

Rosinski, Jenna R., primary, Raasch, Lauren E., additional, Tiburcio, Patrick Barros, additional, Breitbach, Meghan E., additional, Shepherd, Phoenix M., additional, Yamamoto, Keisuke, additional, Razo, Elaina, additional, Krabbe, Nicholas P., additional, Bliss, Mason I., additional, Richardson, Alexander D., additional, Einwalter, Morgan A., additional, Weiler, Andrea M., additional, Sneed, Emily L., additional, Fuchs, Kerri B., additional, Zeng, Xiankun, additional, Noguchi, Kevin K., additional, Morgan, Terry K., additional, Alberts, Alexandra J., additional, Antony, Kathleen M., additional, Kabakov, Sabrina, additional, Ausderau, Karla K., additional, Bohm, Ellie K., additional, Pritchard, Julia C., additional, Spanton, Rachel V., additional, Ver Hoove, James N., additional, Kim, Charlene B. Y., additional, Nork, T. Michael, additional, Katz, Alex W., additional, Rasmussen, Carol A., additional, Hartman, Amy, additional, Mejia, Andres, additional, Basu, Puja, additional, Simmons, Heather A., additional, Eickhoff, Jens C., additional, Friedrich, Thomas C., additional, Aliota, Matthew T., additional, Mohr, Emma L., additional, Dudley, Dawn M., additional, O’Connor, David H., additional, and Newman, Christina M., additional

Published
2022
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43. Assessment of safety and immunogenicity of MHC homozygous iPSC-derived CD34+ hematopoietic progenitors in an NHP model

Author

D’Souza, Saritha S., primary, Kumar, Akhilesh, additional, Maufort, John, additional, Weinfurter, Jason T., additional, Raymond, Matthew, additional, Strelchenko, Nick S., additional, Perrin, Elizabeth, additional, Coonen, Jennifer, additional, Mejia, Andres, additional, Simmons, Heather A., additional, Torbett, Bruce E., additional, Reynolds, Matthew, additional, Thomson, James A., additional, and Slukvin, Igor I., additional

Published
2022
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45. Fetal loss in pregnant rhesus macaques infected with high-dose African-lineage Zika virus

Author

Raasch, Lauren E., primary, Yamamoto, Keisuke, additional, Newman, Christina M., additional, Rosinski, Jenna R., additional, Shepherd, Phoenix M., additional, Razo, Elaina, additional, Crooks, Chelsea M., additional, Bliss, Mason I., additional, Breitbach, Meghan E., additional, Sneed, Emily L., additional, Weiler, Andrea M., additional, Zeng, Xiankun, additional, Noguchi, Kevin K., additional, Morgan, Terry K., additional, Fuhler, Nicole A., additional, Bohm, Ellie K., additional, Alberts, Alexandra J., additional, Havlicek, Samantha J., additional, Kabakov, Sabrina, additional, Mitzey, Ann M., additional, Antony, Kathleen M., additional, Ausderau, Karla K., additional, Mejia, Andres, additional, Basu, Puja, additional, Simmons, Heather A., additional, Eickhoff, Jens C., additional, Aliota, Matthew T., additional, Mohr, Emma L., additional, Friedrich, Thomas C., additional, Golos, Thaddeus G., additional, O’Connor, David H., additional, and Dudley, Dawn M., additional

Published
2022
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46. Efficient in vivo neuronal genome editing in the mouse brain using nanocapsules containing CRISPR-Cas9 ribonucleoproteins

Author

Metzger, Jeanette M., primary, Wang, Yuyuan, additional, Neuman, Samuel S., additional, Snow, Kathy J., additional, Murray, Stephen A., additional, Lutz, Cathleen M., additional, Bondarenko, Viktoriya, additional, Felton, Jesi, additional, Gimse, Kirstan, additional, Xie, Ruosen, additional, Zhao, Yi, additional, Flowers, Matthew T., additional, Simmons, Heather A., additional, Roy, Subhojit, additional, Saha, Krishanu, additional, Levine, Jon, additional, Emborg, Marina E., additional, and Gong, Shaoqin, additional

Published
2022
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47. Human immune globulin treatment controls Zika viremia in pregnant rhesus macaques

Author

Dudley, Dawn M., primary, Koenig, Michelle R., additional, Stewart, Laurel M., additional, Semler, Matthew R., additional, Newman, Christina M., additional, Shepherd, Phoenix M., additional, Yamamoto, Keisuke, additional, Breitbach, Meghan E., additional, Schotzko, Michele, additional, Kohn, Sarah, additional, Antony, Kathleen M., additional, Qiu, Hongyu, additional, Tunga, Priyadarshini, additional, Anderson, Deborah M., additional, Guo, Wendi, additional, Dennis, Maria, additional, Singh, Tulika, additional, Rybarczyk, Sierra, additional, Weiler, Andrea M., additional, Razo, Elaina, additional, Mitzey, Ann, additional, Zeng, Xiankun, additional, Eickhoff, Jens C., additional, Mohr, Emma L., additional, Simmons, Heather A., additional, Fritsch, Michael K., additional, Mejia, Andres, additional, Aliota, Matthew T., additional, Friedrich, Thomas C., additional, Golos, Thaddeus G., additional, Kodihalli, Shantha, additional, Permar, Sallie R., additional, and O’Connor, David H., additional

Published
2022
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48. Enhancing faculty productivity through a centralized communications and project management infrastructure: A case study at the University of Kentucky Markey cancer center

Author

Russell-Simmons, Heather N., Anthony, Cathy, Ballard, Marcia, Coffman, Jonathan, Gilbreath, Donna, Keys, Terry L., Story, Danielle, Rogers, Jennifer, Gosky, David M., and Vanderford, Nathan L.

Subjects
Career development -- Analysis, Project management -- Methods -- Analysis, Infrastructure (Economics) -- Analysis, Business, general, Business
Abstract

Abstract: Academic careers and institutional reputations are closely linked with the ability to secure funding and publish work. In today's competitive environment, it is essential for research to be clearly [...]

Published
2016

50. Infection of the maternal-fetal interface and vertical transmission following low-dose inoculation of pregnant rhesus macaques (Macaca mulatta) with an African-lineage Zika virus

Author

Koenig, Michelle R., primary, Mitzey, Ann M., additional, Morgan, Terry K., additional, Zeng, Xiankun, additional, Simmons, Heather A., additional, Mejia, Andres, additional, Jaimes, Fernanda Leyva, additional, Keding, Logan T., additional, Crooks, Chelsea M., additional, Weiler, Andrea M., additional, Bohm, Ellie K., additional, Aliota, Matthew T., additional, Friedrich, Thomas C., additional, Mohr, Emma L., additional, and Golos, Thaddeus G., additional

Published
2022
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