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2. Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to 5 Years after Diagnosis

Author

Epi Kanker Team B, Cancer, Biostatistiek Onderwijs, Apotheek Bereidingen, Anatomie, MS CGO, MS Hematologie, MS Medische Oncologie, Epi Kanker, JC onderzoeksprogramma Cancer, Smit, Karel C, Derksen, Jeroen W G, Stellato, Rebecca K, van Lanen, Anne-Sophie, Wesselink, Evertine, Belt, Eric J Th, Cloos-van Balen, Marissa, Coene, Peter Paul L O, Dekker, Jan Willem T, de Groot, Jan Willem, Haringhuizen, Annebeth W, van Halteren, Henk K, van Heek, Tjarda T, Helgason, Helgi H, Hendriks, Mathijs P, de Hingh, Ignace H J T, Hoekstra, Ronald, Houtsma, Danny, Janssen, Johan J B, Kok, Niels, Konsten, Joop L M, Los, Maartje, Meijerink, Martijn R, Mekenkamp, Leonie J M, Peeters, Koen C M J, Polée, Marco B, Rietbroek, Ron C, Schiphorst, Anandi H W, Schrauwen, Ruud W M, Schreinemakers, Jennifer, Sie, Mark P S, Simkens, Lieke, Sonneveld, Eric J A, Terheggen, Frederiek, Valkenburg-van Iersel, Liselot, Vles, Wouter J, Wasowicz-Kemps, Daria K, de Wilt, Johannes H W, Kok, Dieuwertje E, Winkels, Renate M, Kampman, Ellen, van Duijnhoven, Fränzel J B, Koopman, Miriam, May, Anne M, Epi Kanker Team B, Cancer, Biostatistiek Onderwijs, Apotheek Bereidingen, Anatomie, MS CGO, MS Hematologie, MS Medische Oncologie, Epi Kanker, JC onderzoeksprogramma Cancer, Smit, Karel C, Derksen, Jeroen W G, Stellato, Rebecca K, van Lanen, Anne-Sophie, Wesselink, Evertine, Belt, Eric J Th, Cloos-van Balen, Marissa, Coene, Peter Paul L O, Dekker, Jan Willem T, de Groot, Jan Willem, Haringhuizen, Annebeth W, van Halteren, Henk K, van Heek, Tjarda T, Helgason, Helgi H, Hendriks, Mathijs P, de Hingh, Ignace H J T, Hoekstra, Ronald, Houtsma, Danny, Janssen, Johan J B, Kok, Niels, Konsten, Joop L M, Los, Maartje, Meijerink, Martijn R, Mekenkamp, Leonie J M, Peeters, Koen C M J, Polée, Marco B, Rietbroek, Ron C, Schiphorst, Anandi H W, Schrauwen, Ruud W M, Schreinemakers, Jennifer, Sie, Mark P S, Simkens, Lieke, Sonneveld, Eric J A, Terheggen, Frederiek, Valkenburg-van Iersel, Liselot, Vles, Wouter J, Wasowicz-Kemps, Daria K, de Wilt, Johannes H W, Kok, Dieuwertje E, Winkels, Renate M, Kampman, Ellen, van Duijnhoven, Fränzel J B, Koopman, Miriam, and May, Anne M

Published
2024

3. Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to Five Years after Diagnosis

Author

Smit, Karel C., Derksen, Jeroen W.G., Stellato, Rebecca K., van Lanen, Anne-Sophie, Wesselink, Evertine, Belt, Eric J.T., Cloos-van Balen, Marissa, Coene, Peter Paul L.O., Dekker, Jan Willem T., de Groot, Jan Willem, Haringhuizen, Annebeth W., van Halteren, Henk K., van Heek, Tjarda T., Helgason, Helgi H., Hendriks, Mathijs P., de Hingh, Ignace H.J.T., Hoekstra, Ronald, Houtsma, Danny, Janssen, Johan J.B., Kok, Niels, Konsten, Joop L.M., Los, Maartje, Meijerink, Martijn R., Mekenkamp, Leonie J.M., Peeters, Koen C.M.J., Polée, Marco B., Rietbroek, Ron C., Schiphorst, Anandi H.W., Schrauwen, Ruud W.M., Schreinemakers, Jennifer, Sie, Mark P.S., Simkens, Lieke, Sonneveld, Eric J.A., Terheggen, Frederiek, Valkenburg-van Iersel, Liselot, Vles, Wouter J., Wasowicz-Kemps, Daria K., de Wilt, Johannes H.W., Kok, Dieuwertje E., Winkels, Renate M., Kampman, Ellen, van Duijnhoven, Fränzel J.B., Koopman, Miriam, May, Anne M., Smit, Karel C., Derksen, Jeroen W.G., Stellato, Rebecca K., van Lanen, Anne-Sophie, Wesselink, Evertine, Belt, Eric J.T., Cloos-van Balen, Marissa, Coene, Peter Paul L.O., Dekker, Jan Willem T., de Groot, Jan Willem, Haringhuizen, Annebeth W., van Halteren, Henk K., van Heek, Tjarda T., Helgason, Helgi H., Hendriks, Mathijs P., de Hingh, Ignace H.J.T., Hoekstra, Ronald, Houtsma, Danny, Janssen, Johan J.B., Kok, Niels, Konsten, Joop L.M., Los, Maartje, Meijerink, Martijn R., Mekenkamp, Leonie J.M., Peeters, Koen C.M.J., Polée, Marco B., Rietbroek, Ron C., Schiphorst, Anandi H.W., Schrauwen, Ruud W.M., Schreinemakers, Jennifer, Sie, Mark P.S., Simkens, Lieke, Sonneveld, Eric J.A., Terheggen, Frederiek, Valkenburg-van Iersel, Liselot, Vles, Wouter J., Wasowicz-Kemps, Daria K., de Wilt, Johannes H.W., Kok, Dieuwertje E., Winkels, Renate M., Kampman, Ellen, van Duijnhoven, Fränzel J.B., Koopman, Miriam, and May, Anne M.

Abstract

Introduction: Physical activity (PA) is associated with higher quality of life and probably better prognosis among colorectal cancer (CRC) patients. This study focuses on determinants of PA among CRC patients from diagnosis until five years post-diagnosis.Methods: Sociodemographic and disease-related factors of participants of two large CRC cohort studies were combined. Moderate-to-vigorous PA during sport and leisure time (MVPA-SL) was measured at diagnosis (T0) and six, twelve, twenty-four, and sixty (T6 to T60) months post-diagnosis, using the SQUASH questionnaire. Mixed-effects models were performed to identify sociodemographic and disease-related determinants of MVPA-SL, separately for stage I-III colon (CC), stage I-III rectal cancer (RC), and stage IV CRC (T0 and T6 only). Associations were defined as consistently present when significant at ≥4 timepoints for the stage I-III subsets. MVPA-SL levels were compared with an age- and sex-matched sample of the general Dutch population.Results: In total, 2905 CC, 1459 RC and 436 stage IV CRC patients were included. Patients with higher fatigue scores, and women compared to men had consistently lower MVPA-SL levels over time, regardless of tumor type and stage. At T6, having a stoma was significantly associated with lower MVPA-SL among stage I-III RC patients. Systemic therapy and radiotherapy were not significantly associated with MVPA-SL changes at T6. Compared to the general population, MVPA-SL levels of CRC patients were lower at all timepoints, most notably at T6.Conclusions: Female sex and higher fatigue scores were consistent determinants of lower MVPA-SL levels among all CRC patients, and MVPA-SL levels were lowest at six months post-diagnosis. Our results can inform the design of intervention studies aimed at improving PA, and guide healthcare professionals in optimizing individualized support.

Published
2024

5. Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to Five Years after Diagnosis

Author

Smit, Karel C., primary, Derksen, Jeroen W.G., additional, Stellato, Rebecca K., additional, van Lanen, Anne-Sophie, additional, Wesselink, Evertine, additional, Belt, Eric J. Th., additional, Cloos-van Balen, Marissa, additional, Coene, Peter Paul L.O., additional, Dekker, Jan Willem T., additional, de Groot, Jan Willem, additional, Haringhuizen, Annebeth W., additional, van Halteren, Henk K., additional, van Heek, Tjarda T., additional, Helgason, Helgi H., additional, Hendriks, Mathijs P., additional, de Hingh, Ignace H.J.T., additional, Hoekstra, Ronald, additional, Houtsma, Danny, additional, Janssen, Johan J.B., additional, Kok, Niels, additional, Konsten, Joop L.M., additional, Los, Maartje, additional, Meijerink, Martijn R., additional, Mekenkamp, Leonie J.M., additional, Peeters, Koen C.M.J., additional, Polée, Marco B., additional, Rietbroek, Ron C., additional, Schiphorst, Anandi H.W., additional, Schrauwen, Ruud W.M., additional, Schreinemakers, Jennifer, additional, Sie, Mark P.S., additional, Simkens, Lieke, additional, Sonneveld, Eric J.A., additional, Terheggen, Frederiek, additional, Valkenburg-van Iersel, Liselot, additional, Vles, Wouter J., additional, Wasowicz-Kemps, Daria K., additional, de Wilt, Johannes H.W., additional, Kok, Dieuwertje E., additional, Winkels, Renate M., additional, Kampman, Ellen, additional, van Duijnhoven, Fränzel J.B., additional, Koopman, Miriam, additional, and May, Anne M., additional

Published
2023
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7. Maintenance treatment with capecitabine and bevacizumab in metastatic colorectal cancer (CAIRO3): a phase 3 randomised controlled trial of the Dutch Colorectal Cancer Group

Author

Simkens, Lieke H J, van Tinteren, Harm, May, Anne, ten Tije, Albert J, Creemers, Geert-Jan M, Loosveld, Olaf J L, de Jongh, Felix E, Erdkamp, Frans L G, Erjavec, Zoran, van der Torren, Adelheid M E, Tol, Jolien, Braun, Hans J J, Nieboer, Peter, van der Hoeven, Jacobus J M, Haasjes, Janny G, Jansen, Rob L H, Wals, Jaap, Cats, Annemieke, Derleyn, Veerle A, Honkoop, Aafke H, Mol, Linda, Punt, Cornelis J A, and Koopman, Miriam

Published
2015
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11. A propensity score‐matched analysis of oncological outcome after systemic therapy for stage IV colorectal cancer: Impact of synchronous ovarian metastases.

Author

van der Meer, Richard, Bakkers, Checca, van Erning, Felice N., Simkens, Lieke H. J., de Hingh, Ignace H. J. T., and Roumen, Rudi M. H.

Subjects
COLORECTAL cancer, INTRAVENOUS therapy, OVARIAN cancer, METASTASIS, PROPENSITY score matching, OVERALL survival
Abstract

The reported incidence of synchronous and metachronous ovarian metastases (OM) from colorectal cancer (CRC) is ~3.4%. OM from CRC are often considered sanctuary sites due to their lower sensitivity to systemic treatment. It has thus been hypothesized that the presence of OM decreases overall survival. Therefore, the purpose of our study was to evaluate the impact of synchronous OM on overall survival in female patients with stage IV CRC treated with systemic therapy alone with palliative intent. The present study used data from the Netherlands Cancer Registry and included female CRC patients with synchronous systemic metastases who were treated with systemic therapy between 2008 and 2018. A subsample was created using propensity score matching to create comparable groups. Propensity scores were determined using a logistic regression model in which the dependent variable was the presence of OM and the independent variables were the variables that differed significantly between both groups. Our study included 5253 patients with stage IV CRC that received systemic therapy. Among these patients, 161 (3%) had OM while 5092 (97%) had extra‐ovarian metastases only. Three‐year overall survival rates did not show a significant difference between patients with OM compared to patients without ovarian metastases. Moreover, the propensity score‐matched analysis showed that the presence of OM in patients treated with systemic therapy for stage IV CRC disease was not associated with decreased 3‐year overall survival. However, the results of the present study should be interpreted with caution, due to its observational character and used selection criteria. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Trajectories of health-related quality of life and psychological distress in patients with colorectal cancer: A population-based study

Author

Qaderi, Seyed M., primary, van der Heijden, Joost A.G., additional, Verhoeven, Rob H.A., additional, de Wilt, Johannes H.W., additional, Custers, Jose A.E., additional, Beets, Geerard L., additional, Belt, Eric J.Th., additional, Berbée, Maaike, additional, Beverdam, Frederique H., additional, Blankenburgh, Ruud, additional, Coene, Peter Paul L.O., additional, de Groot, Jan Willem B., additional, de Hingh, Ignace H.J.T., additional, de Vos, Aad I., additional, Dekker, Jan Willem T., additional, Erdkamp, Frans L.G., additional, Haringhuizen, Annebeth W., additional, Helgason, Helgi H., additional, Hendriks, Mathijs P., additional, Hoekstra, Ronald, additional, Ijzermans, Jan N.M., additional, Jansen, Jan, additional, Kloppenberg, Frank W.H., additional, Los, Maartje, additional, Meijerink, Martijn R., additional, Mekenkamp, Leonie J.M., additional, Nieboer, Peter, additional, Peeters, Koen C.M.J., additional, Peters, Natascha A.J.B., additional, Polée, Marco B., additional, Pruijt, Johannes F.M., additional, van Ufford-Mannesse, Patricia Quarles, additional, Rietbroek, Ron C., additional, Schiphorst, Anandi H.W., additional, van der Velden, Arjan Schouten, additional, Schrauwen, Ruud W.M., additional, Sie, Mark P.S., additional, Simkens, Lieke, additional, Sommeijer, Dirkje W., additional, Sonneveld, Dirk J.A., additional, Spierings, Leontine E.A., additional, Stockmann, Hein B.A.C., additional, Talsma, Koen, additional, ten Tije, Albert J., additional, Terheggen, Frederiek, additional, Tjin-A-Ton, Manuel L.R., additional, Valkenburg-van Iersel, Liselot B.J., additional, van Cruijsen, Hester, additional, Velden, Ankie M.T. van der, additional, van Dodewaard-de Jong, Joyce M., additional, van Lent, Anja U.G., additional, van Voorthuizen, Theo, additional, Vermaas, Maarten, additional, Vles, Wouter J., additional, Vogelaar, Jeroen F.J., additional, and Zimmerman, David D.E., additional

Published
2021
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13. The Prospective Dutch Colorectal Cancer (PLCRC) cohort: real-world data facilitating research and clinical care

Author

Derksen, Jeroen W. G., Vink, Geraldine R., Elferink, Marloes A. G., Roodhart, Jeanine M. L., Verkooijen, Helena M., van Grevenstein, Wilhelmina M. U., Siersema, Peter D., May, Anne M., Koopman, Miriam, Beets, Geerard L., Belt, Eric J. Th., Berbée, Maaike, Beverdam, Frederique H., Blankenburgh, Ruud, Coene, Peter Paul L. O., van Cruijsen, Hester, Dekker, Jan Willem T., van Dodewaard-de Jong, Joyce M., Erdkamp, Frans L. G., de Groot, Jan Willem B., Haringhuizen, Annebeth W., Helgason, Helgi H., Hendriks, Mathijs P., de Hingh, Ignace H. J. T., Hoekstra, Ronald, Ijzermans, Jan N. M., Jansen, Jan, Kloppenberg, Frank W. H., van Lent, Anja U. G., Los, Maartje, Meijerink, Martijn R., Mekenkamp, Leonie J. M., Nieboer, Peter, Peeters, Koen C. M. J., Peters, Natascha A. J. B., Polée, Marco B., Pruijt, Johannes F. M., Punt, Cornelis J. A., van Ufford-Mannesse, Patricia Quarles, Rietbroek, Ron C., Schiphorst, Anandi H. W., van der Velden, Arjan Schouten, Schrauwen, Ruud W. M., Sie, Mark P. S., Simkens, Lieke, Sommeijer, Dirkje W., Sonneveld, Dirk J. A., Spierings, Leontine E. A., Stockmann, Hein B. A. C., Talsma, Koen, Terheggen, Frederiek, ten Tije, Albert J., Tjin-A-Ton, Manuel L. R., Valkenburg-van Iersel, Liselot B. J., Veenstra, Renzo P., van der Velden, Ankie M. T., Vermaas, Maarten, Vles, Wouter J., Vogelaar, Jeroen F. J., van Voorthuizen, Theo, de Vos, Aad I., Wegdam, Johannes A., de Wilt, Johannes H. W., Zimmerman, David D. E., Surgery, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Epidemiologie, CCA - Cancer Treatment and quality of life, Radiology and nuclear medicine, Internal medicine, and VU University medical center

Subjects
Male, medicine.medical_specialty, Colorectal cancer, Epidemiology, Science, Population, MODELS, MEDLINE, Logistic regression, Representativeness heuristic, Article, 03 medical and health sciences, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 0302 clinical medicine, Cancer epidemiology, Medical research, All institutes and research themes of the Radboud University Medical Center, SDG 3 - Good Health and Well-being, Multidisciplinary approach, COLON, medicine, Humans, 030212 general & internal medicine, Prospective Studies, Registries, education, Aged, Netherlands, Aged, 80 and over, education.field_of_study, Multidisciplinary, business.industry, Middle Aged, medicine.disease, Cancer registry, TRIALS, Outcomes research, 030220 oncology & carcinogenesis, Family medicine, Cohort, Medicine, Female, business, Colorectal Neoplasms
Abstract

Real-world data (RWD) sources are important to advance clinical oncology research and evaluate treatments in daily practice. Since 2013, the Prospective Dutch Colorectal Cancer (PLCRC) cohort, linked to the Netherlands Cancer Registry, serves as an infrastructure for scientific research collecting additional patient-reported outcomes (PRO) and biospecimens. Here we report on cohort developments and investigate to what extent PLCRC reflects the “real-world”. Clinical and demographic characteristics of PLCRC participants were compared with the general Dutch CRC population (n = 74,692, Dutch-ref). To study representativeness, standardized differences between PLCRC and Dutch-ref were calculated, and logistic regression models were evaluated on their ability to distinguish cohort participants from the Dutch-ref (AU-ROC 0.5 = preferred, implying participation independent of patient characteristics). Stratified analyses by stage and time-period (2013–2016 and 2017–Aug 2019) were performed to study the evolution towards RWD. In August 2019, 5744 patients were enrolled. Enrollment increased steeply, from 129 participants (1 hospital) in 2013 to 2136 (50 of 75 Dutch hospitals) in 2018. Low AU-ROC (0.65, 95% CI: 0.64–0.65) indicates limited ability to distinguish cohort participants from the Dutch-ref. Characteristics that remained imbalanced in the period 2017–Aug’19 compared with the Dutch-ref were age (65.0 years in PLCRC, 69.3 in the Dutch-ref) and tumor stage (40% stage-III in PLCRC, 30% in the Dutch-ref). PLCRC approaches to represent the Dutch CRC population and will ultimately meet the current demand for high-quality RWD. Efforts are ongoing to improve multidisciplinary recruitment which will further enhance PLCRC’s representativeness and its contribution to a learning healthcare system.

Published
2021
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14. Survival of patients with deficient mismatch repair metastatic colorectal cancer in the pre-immunotherapy era

Author

Verpleegafdeling Medische Oncologie, Onderzoek Medische Oncologie, Cancer, Epidemiology & Health Economics, JC onderzoeksprogramma Kanker, MS Medische Oncologie, Wensink, G Emerens, Elferink, Marloes A G, May, Anne M, Mol, Linda, Hamers, Patricia A H, Bakker, Sandra D, Creemers, Geert-Jan, de Groot, Jan Willem B, de Klerk, Gerty J, Haberkorn, Brigitte C M, Haringhuizen, Annebeth W, Hoekstra, Ronald, Hunting, J Cornelis B, Kerver, Emile D, Mathijssen-van Stein, Danielle, Polée, Marco B, Pruijt, Johannes F M, Quarles van Ufford-Mannesse, Patricia, Radema, Sandra, Rietbroek, Ronald C, Simkens, Lieke H J, Tanis, Bea C, Ten Bokkel Huinink, Daan, Tjin-A-Ton, Manuel L R, Tromp-van Driel, Cathrien S, Troost, Monique M, van de Wouw, Agnes J, van den Berkmortel, Franchette W P J, van der Pas, Anke J M, van der Velden, Ankie M T, van Dijk, Marjan A, van Dodewaard-de Jong, Joyce M, van Druten, Edith B, van Voorthuizen, Theo, Jan Veldhuis, Gerrit, Verheul, Henk M W, Vestjens, Hanneke J H M J, Vincent, Jeroen, Kranenburg, Onno W, Punt, Cornelis J A, Vink, Geraldine R, Roodhart, Jeanine M L, Koopman, Miriam, Verpleegafdeling Medische Oncologie, Onderzoek Medische Oncologie, Cancer, Epidemiology & Health Economics, JC onderzoeksprogramma Kanker, MS Medische Oncologie, Wensink, G Emerens, Elferink, Marloes A G, May, Anne M, Mol, Linda, Hamers, Patricia A H, Bakker, Sandra D, Creemers, Geert-Jan, de Groot, Jan Willem B, de Klerk, Gerty J, Haberkorn, Brigitte C M, Haringhuizen, Annebeth W, Hoekstra, Ronald, Hunting, J Cornelis B, Kerver, Emile D, Mathijssen-van Stein, Danielle, Polée, Marco B, Pruijt, Johannes F M, Quarles van Ufford-Mannesse, Patricia, Radema, Sandra, Rietbroek, Ronald C, Simkens, Lieke H J, Tanis, Bea C, Ten Bokkel Huinink, Daan, Tjin-A-Ton, Manuel L R, Tromp-van Driel, Cathrien S, Troost, Monique M, van de Wouw, Agnes J, van den Berkmortel, Franchette W P J, van der Pas, Anke J M, van der Velden, Ankie M T, van Dijk, Marjan A, van Dodewaard-de Jong, Joyce M, van Druten, Edith B, van Voorthuizen, Theo, Jan Veldhuis, Gerrit, Verheul, Henk M W, Vestjens, Hanneke J H M J, Vincent, Jeroen, Kranenburg, Onno W, Punt, Cornelis J A, Vink, Geraldine R, Roodhart, Jeanine M L, and Koopman, Miriam

Published
2021

15. Work Ability in Patients With Stage I to IV Colon Cancer: Results of the Dutch Prospective Colorectal Cancer Cohort

Author

Franken, Mira D., Vink, Geraldine, van Grevenstein, Wilhelmina M.U., Verkooijen, Helena M., Punt, Cornelis J.A., Koopman, Miriam, May, Anne M., Beets, Geerard L., Belt, Eric J.Th., Berbée, Maaike, Beverdam, Frederique H., Blankenburgh, Ruud, Coene, Peter Paul L.O., de Groot, Jan Willem B., de Hingh, Ignace H.J.T., de Vos, Aad I., de Wilt, Johannes H.W., Dekker, Jan Willem T., Erdkamp, Frans L.G., Haringhuizen, Annebeth W., Helgason, Helgi H., Hendriks, Mathijs P., Hoekstra, Ronald, Ijzermans, Jan N.M., Jansen, Jan, Kloppenberg, Frank W.H., Los, Maartje, Meijerink, Martijn R., Mekenkamp, Leonie J.M., Nieboer, Peter, Peeters, Koen C.M.J., Peters, Natascha A.J.B., Pruijt, Johannes F.M., van Ufford-Mannesse, Patricia Quarles, Rietbroek, Ron C., Schiphorst, Anandi H.W., Sie, Mark P.S., Simkens, Lieke H.J., Sommeijer, Dirkje W., Spierings, Leontine E.A., Stockmann, Hein B.A.C., ten Tije, Albert J., Terheggen, Frederiek, Tjin-A-Ton, Manuel L.R., Valkenburg-van Iersel, Liselot B.J., van Cruijsen, Hester, van der Velden, Ankie M.T., van Dodewaard-de Jong, Joyce M., van Lent, Anja U.G., Voorthuizen, Theo van, Vermaas, Maarten, Vles, Wouter J., Vogelaar, Jeroen F.J., and Zimmerman, David D.E.

Published
2023
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16. Loss of skeletal muscle index and survival in patients with metastatic colorectal cancer : Secondary analysis of the phase 3 CAIRO3 trial

Author

Kurk, Sophie A, Peeters, Petra H M, Dorresteijn, Bram, de Jong, Pim A, Jourdan, Marion, Creemers, Geert-Jan M, Erdkamp, Frans L G, de Jongh, Felix E, Kint, Peter A M, Poppema, Boelo J, Radema, Sandra A, Simkens, Lieke H J, Tanis, Bea C, Tjin-A-Ton, Manuel L R, Van Der Velden, Ankie, Punt, Cornelis J A, Koopman, Miriam, May, Anne M, Kurk, Sophie A, Peeters, Petra H M, Dorresteijn, Bram, de Jong, Pim A, Jourdan, Marion, Creemers, Geert-Jan M, Erdkamp, Frans L G, de Jongh, Felix E, Kint, Peter A M, Poppema, Boelo J, Radema, Sandra A, Simkens, Lieke H J, Tanis, Bea C, Tjin-A-Ton, Manuel L R, Van Der Velden, Ankie, Punt, Cornelis J A, Koopman, Miriam, and May, Anne M

Published
2020

17. Loss of skeletal muscle index and survival in patients with metastatic colorectal cancer: Secondary analysis of the phase 3 CAIRO3 trial

Author

Arts-assistenten Radiotherapie, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Researchgr. Systems Radiology, Regenerative Medicine and Stem Cells, Infection & Immunity, Circulatory Health, MS Medische Oncologie, Epidemiology & Health Economics, Kurk, Sophie A, Peeters, Petra H M, Dorresteijn, Bram, de Jong, Pim A, Jourdan, Marion, Creemers, Geert-Jan M, Erdkamp, Frans L G, de Jongh, Felix E, Kint, Peter A M, Poppema, Boelo J, Radema, Sandra A, Simkens, Lieke H J, Tanis, Bea C, Tjin-A-Ton, Manuel L R, Van Der Velden, Ankie, Punt, Cornelis J A, Koopman, Miriam, May, Anne M, Arts-assistenten Radiotherapie, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Researchgr. Systems Radiology, Regenerative Medicine and Stem Cells, Infection & Immunity, Circulatory Health, MS Medische Oncologie, Epidemiology & Health Economics, Kurk, Sophie A, Peeters, Petra H M, Dorresteijn, Bram, de Jong, Pim A, Jourdan, Marion, Creemers, Geert-Jan M, Erdkamp, Frans L G, de Jongh, Felix E, Kint, Peter A M, Poppema, Boelo J, Radema, Sandra A, Simkens, Lieke H J, Tanis, Bea C, Tjin-A-Ton, Manuel L R, Van Der Velden, Ankie, Punt, Cornelis J A, Koopman, Miriam, and May, Anne M

Published
2020

19. Survival of patients with deficient mismatch repair metastatic colorectal cancer in the pre-immunotherapy era

Author

Wensink, G. Emerens, primary, Elferink, Marloes A. G., additional, May, Anne M., additional, Mol, Linda, additional, Hamers, Patricia A. H., additional, Bakker, Sandra D., additional, Creemers, Geert-Jan, additional, de Groot, Jan Willem B., additional, de Klerk, Gerty J., additional, Haberkorn, Brigitte C. M., additional, Haringhuizen, Annebeth W., additional, Hoekstra, Ronald, additional, Hunting, J. Cornelis B., additional, Kerver, Emile D., additional, Mathijssen-van Stein, Danielle, additional, Polée, Marco B., additional, Pruijt, Johannes F. M., additional, Quarles van Ufford-Mannesse, Patricia, additional, Radema, Sandra, additional, Rietbroek, Ronald C., additional, Simkens, Lieke H. J., additional, Tanis, Bea C., additional, ten Bokkel Huinink, Daan, additional, Tjin-A-Ton, Manuel L. R., additional, Tromp-van Driel, Cathrien S., additional, Troost, Monique M., additional, van de Wouw, Agnes J., additional, van den Berkmortel, Franchette W. P. J., additional, van der Pas, Anke J. M., additional, van der Velden, Ankie M. T., additional, van Dijk, Marjan A., additional, van Dodewaard-de Jong, Joyce M., additional, van Druten, Edith B., additional, van Voorthuizen, Theo, additional, Jan Veldhuis, Gerrit, additional, Verheul, Henk M. W., additional, Vestjens, Hanneke J. H. M. J., additional, Vincent, Jeroen, additional, Kranenburg, Onno W., additional, Punt, Cornelis J. A., additional, Vink, Geraldine R., additional, Roodhart, Jeanine M. L., additional, and Koopman, Miriam, additional

Published
2020
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21. Updated Survival Analysis of the Randomized Phase III Trial of S-1 Versus Capecitabine in the First-Line Treatment of Metastatic Colorectal Cancer by the Dutch Colorectal Cancer Group

Author

Kwakman, Johannes J M, van Werkhoven, Erik, Simkens, Lieke H J, van Rooijen, Johan M, van de Wouw, Yes A J, Tije, Albert J Ten, Creemers, Geert-Jan M, Hendriks, Mathijs P, Los, Maartje, van Alphen, Robbert J, Polée, Marco B, Muller, Erik W, van der Velden, Ankie M T, van Voorthuizen, Theo, Koopman, Miriam, Mol, Linda, Punt, Cornelis J A, Kwakman, Johannes J M, van Werkhoven, Erik, Simkens, Lieke H J, van Rooijen, Johan M, van de Wouw, Yes A J, Tije, Albert J Ten, Creemers, Geert-Jan M, Hendriks, Mathijs P, Los, Maartje, van Alphen, Robbert J, Polée, Marco B, Muller, Erik W, van der Velden, Ankie M T, van Voorthuizen, Theo, Koopman, Miriam, Mol, Linda, and Punt, Cornelis J A

Published
2019

22. Skeletal muscle mass loss and dose-limiting toxicities in metastatic colorectal cancer patients

Author

Kurk, Sophie, Peeters, Petra, Stellato, Rebecca, Dorresteijn, B, de Jong, Pim, Jourdan, Marion, Creemers, Geert-Jan, Erdkamp, Frans, de Jongh, Felix, Kint, Peter, Simkens, Lieke, Tanis, Bea, Tjin-A-Ton, Manuel, Van Der Velden, Ankie, Punt, Cornelis, Koopman, Miriam, May, Anne, Kurk, Sophie, Peeters, Petra, Stellato, Rebecca, Dorresteijn, B, de Jong, Pim, Jourdan, Marion, Creemers, Geert-Jan, Erdkamp, Frans, de Jongh, Felix, Kint, Peter, Simkens, Lieke, Tanis, Bea, Tjin-A-Ton, Manuel, Van Der Velden, Ankie, Punt, Cornelis, Koopman, Miriam, and May, Anne

Published
2019

23. Updated Survival Analysis of the Randomized Phase III Trial of S-1 Versus Capecitabine in the First-Line Treatment of Metastatic Colorectal Cancer by the Dutch Colorectal Cancer Group

Author

MS CGO, MS Medische Oncologie, Kwakman, Johannes J M, van Werkhoven, Erik, Simkens, Lieke H J, van Rooijen, Johan M, van de Wouw, Yes A J, Tije, Albert J Ten, Creemers, Geert-Jan M, Hendriks, Mathijs P, Los, Maartje, van Alphen, Robbert J, Polée, Marco B, Muller, Erik W, van der Velden, Ankie M T, van Voorthuizen, Theo, Koopman, Miriam, Mol, Linda, Punt, Cornelis J A, MS CGO, MS Medische Oncologie, Kwakman, Johannes J M, van Werkhoven, Erik, Simkens, Lieke H J, van Rooijen, Johan M, van de Wouw, Yes A J, Tije, Albert J Ten, Creemers, Geert-Jan M, Hendriks, Mathijs P, Los, Maartje, van Alphen, Robbert J, Polée, Marco B, Muller, Erik W, van der Velden, Ankie M T, van Voorthuizen, Theo, Koopman, Miriam, Mol, Linda, and Punt, Cornelis J A

Published
2019

24. Implementation, participation and satisfaction rates of a web-based decision support tool for patients with metastatic colorectal cancer

Author

MS Medische Oncologie, Cancer, Keikes, Lotte, de Vos-Geelen, Judith, de Groot, Jan Willem B, Punt, Cornelis J A, Simkens, Lieke H J, Trajkovic-Vidakovic, Marija, Portielje, Johanneke E A, Vos, Allert H, Beerepoot, Laurens V, Hunting, Cornelis B, Koopman, Miriam, van Oijen, Martijn G H, MS Medische Oncologie, Cancer, Keikes, Lotte, de Vos-Geelen, Judith, de Groot, Jan Willem B, Punt, Cornelis J A, Simkens, Lieke H J, Trajkovic-Vidakovic, Marija, Portielje, Johanneke E A, Vos, Allert H, Beerepoot, Laurens V, Hunting, Cornelis B, Koopman, Miriam, and van Oijen, Martijn G H

Published
2019

25. Skeletal muscle mass loss and dose-limiting toxicities in metastatic colorectal cancer patients

Author

Arts-assistenten Radiotherapie, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Biostatistiek Onderwijs, JC onderzoeksprogramma Methodologie, Researchgr. Systems Radiology, MS Medische Oncologie, Epidemiology & Health Economics, Kurk, Sophie, Peeters, Petra, Stellato, Rebecca, Dorresteijn, B, de Jong, Pim, Jourdan, Marion, Creemers, Geert-Jan, Erdkamp, Frans, de Jongh, Felix, Kint, Peter, Simkens, Lieke, Tanis, Bea, Tjin-A-Ton, Manuel, Van Der Velden, Ankie, Punt, Cornelis, Koopman, Miriam, May, Anne, Arts-assistenten Radiotherapie, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Biostatistiek Onderwijs, JC onderzoeksprogramma Methodologie, Researchgr. Systems Radiology, MS Medische Oncologie, Epidemiology & Health Economics, Kurk, Sophie, Peeters, Petra, Stellato, Rebecca, Dorresteijn, B, de Jong, Pim, Jourdan, Marion, Creemers, Geert-Jan, Erdkamp, Frans, de Jongh, Felix, Kint, Peter, Simkens, Lieke, Tanis, Bea, Tjin-A-Ton, Manuel, Van Der Velden, Ankie, Punt, Cornelis, Koopman, Miriam, and May, Anne

Published
2019

27. Loss of skeletal muscle index and survival in patients with metastatic colorectal cancer: Secondary analysis of the phase 3 CAIRO3 trial

Author

Kurk, Sophie A., primary, Peeters, Petra H. M., additional, Dorresteijn, Bram, additional, de Jong, Pim A., additional, Jourdan, Marion, additional, Creemers, Geert‐Jan M., additional, Erdkamp, Frans L. G., additional, de Jongh, Felix E., additional, Kint, Peter A. M., additional, Poppema, Boelo J., additional, Radema, Sandra A., additional, Simkens, Lieke H. J., additional, Tanis, Bea C., additional, Tjin‐A‐Ton, Manuel L. R., additional, Van Der Velden, Ankie, additional, Punt, Cornelis J. A., additional, Koopman, Miriam, additional, and May, Anne M., additional

Published
2019
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28. Updated Survival Analysis of the Randomized Phase III Trial of S-1 Versus Capecitabine in the First-Line Treatment of Metastatic Colorectal Cancer by the Dutch Colorectal Cancer Group

Author

Kwakman, Johannes J.M., primary, van Werkhoven, Erik, additional, Simkens, Lieke H.J., additional, van Rooijen, Johan M., additional, van de Wouw, Yes A.J., additional, Tije, Albert J. ten, additional, Creemers, Geert-Jan M., additional, Hendriks, Mathijs P., additional, Los, Maartje, additional, van Alphen, Robbert J., additional, Polée, Marco B., additional, Muller, Erik W., additional, van der Velden, Ankie M.T., additional, van Voorthuizen, Theo, additional, Koopman, Miriam, additional, Mol, Linda, additional, and Punt, Cornelis J.A., additional

Published
2019
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29. Skeletal muscle mass loss and dose‐limiting toxicities in metastatic colorectal cancer patients

Author

Kurk, Sophie, primary, Peeters, Petra, additional, Stellato, Rebecca, additional, Dorresteijn, B., additional, Jong, Pim, additional, Jourdan, Marion, additional, Creemers, Geert‐Jan, additional, Erdkamp, Frans, additional, Jongh, Felix, additional, Kint, Peter, additional, Simkens, Lieke, additional, Tanis, Bea, additional, Tjin‐A‐Ton, Manuel, additional, Van Der Velden, Ankie, additional, Punt, Cornelis, additional, Koopman, Miriam, additional, and May, Anne, additional

Published
2019
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30. Loss of skeletal muscle index and survival in patients with metastatic colorectal cancer: Secondary analysis of the phase 3 CAIRO3 trial.

Author

Kurk, Sophie A., Peeters, Petra H. M., Dorresteijn, Bram, Jong, Pim A., Jourdan, Marion, Creemers, Geert‐Jan M., Erdkamp, Frans L. G., Jongh, Felix E., Kint, Peter A. M., Poppema, Boelo J., Radema, Sandra A., Simkens, Lieke H. J., Tanis, Bea C., Tjin‐A‐Ton, Manuel L. R., Van Der Velden, Ankie, Punt, Cornelis J. A., Koopman, Miriam, and May, Anne M.

Subjects
SKELETAL muscle, COLORECTAL cancer, METASTASIS, SECONDARY analysis, BODY mass index
Abstract

Background: Low skeletal muscle index (SMI) in metastatic colorectal cancer (mCRC) patients is associated with poor outcomes. The prognostic impact of SMI changes during consecutive palliative systemic treatments is unknown. Methods: This is a retrospective analysis of the phase 3 CAIRO3 study. The CAIRO3 study randomized 557 patients between maintenance capecitabine + bevacizumab (CAP‐B) or observation, after six cycles capecitabine + oxaliplatin + bevacizumab (CAPOX‐B). Upon first disease progression (PD1), CAPOX‐B was reintroduced until second progression (PD2). SMI was assessed by computed tomography (CT) (total 1355 scans). SMI and body mass index (BMI) changes were analyzed for three time‐periods; p1: during initial CAPOX‐B, p2: randomization to PD1, and p3: PD1 to PD2. The association between absolute and change in SMI and BMI (both per 1 standard deviation) during p1‐p3, with PD1, PD2, and survival was studied by Cox regression models. Results: This analysis included 450 of the 557 patients randomized in the CAIRO3 study. Mean SMI decreased during p1: mean −0.6 SMI units [95% CI −1.07;‐0.26] and p3: −2.2 units [−2.7;‐1.8], whereas during p2, SMI increased + 1.2 units [0.8‐1.6]. BMI changes did not reflect changes in SMI. SMI loss during p2 and p3 was significantly associated with shorter survival (HR 1.19 [1.09‐1.35]; 1.54 [1.31‐1.79], respectively). Sarcopenia at PD1 was significantly associated with early PD2 (HR 1.40 [1.10‐1.70]). BMI loss independent of SMI loss was only associated with shorter overall survival during p3 (HR 1.35 [1.14‐1.63]). Conclusions: In mCRC patients, SMI loss during palliative systemic treatment was related with early disease progression and reduced survival. BMI did not reflect changes in SMI and could not identify patients at risk of poor outcome during early treatment lines. [ABSTRACT FROM AUTHOR]

Published
2020
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32. Incidence of capecitabine-related cardiotoxicity in different treatment schedules of metastatic colorectal cancer: A retrospective analysis of the CAIRO studies of the Dutch Colorectal Cancer Group

Author

MS Medische Oncologie, Cancer, Kwakman, Johannes J M, Simkens, Lieke H J, Mol, Linda, Kok, Wouter E M, Koopman, Miriam, Punt, Cornelis J A, MS Medische Oncologie, Cancer, Kwakman, Johannes J M, Simkens, Lieke H J, Mol, Linda, Kok, Wouter E M, Koopman, Miriam, and Punt, Cornelis J A

Published
2017

33. Impact of skeletal muscle index (SMI) loss during palliative systemic treatment (Tx) on time to progression and overall survival (OS) in metastatic colorectal cancer (mCRC) patients.

Author

Kurk, Sophie, primary, Peeters, Petra H.M., additional, Stellato, Rebecca K., additional, Dorresteijn, Bram, additional, Jourdan, Marion, additional, Creemers, Geert-Jan, additional, Erdkamp, Frans, additional, de Jongh, Felix E., additional, Kint, Petrus Alouisius Maria, additional, Poppema, Boelo Jan, additional, Radema, Sandra Anita, additional, Simkens, Lieke H, additional, Tanis, Bea, additional, Tjin-A-Ton, Manuel Lucien Roy, additional, Van Der Velden, Ankie, additional, Punt, Cornelis J. A., additional, Koopman, Miriam, additional, and May, Anne Maria, additional

Published
2017
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34. Maintenance treatment in metastatic colorectal cancer

Author

Simkens, Lieke H J, van Tinteren, Harm, Punt, Cornelis J A, and Koopman, Miriam

Subjects
Male, Letter, Organoplatinum Compounds, Comment, Leucovorin, Angiogenesis Inhibitors, Maintenance Chemotherapy, Bevacizumab, Antineoplastic Combined Chemotherapy Protocols, Humans, Female, Fluorouracil, Colorectal Neoplasms, Capecitabine
Published
2015

35. Randomized phase 3 study of S-1 versus capecitabine in the first-line treatment of metastatic colorectal cancer (mCRC): The SALTO study of the Dutch Colorectal Cancer Group.

Author

Punt, Cornelis J. A., primary, Simkens, Lieke H, additional, Van Rooijen, Johan, additional, Van de Wouw, Agnes W, additional, Loosveld, Olaf, additional, Creemers, Geert-Jan, additional, Hendriks, Mathijs P, additional, Los, Maartje, additional, Van Alphen, Robbert Jeroen, additional, Polee, Marco, additional, Muller, Erik W, additional, Van Der Velden, Ankie, additional, Van Voorthuizen, Thymen, additional, Koopman, Miriam, additional, Mol, Linda, additional, Kwakman, Johannes J, additional, and van Werkhoven, Erik D., additional

Published
2016
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37. Maintenance treatment in metastatic colorectal cancer

Author

MS Medische Oncologie, Cancer, Simkens, Lieke H J, van Tinteren, Harm, Punt, Cornelis J A, Koopman, Miriam, MS Medische Oncologie, Cancer, Simkens, Lieke H J, van Tinteren, Harm, Punt, Cornelis J A, and Koopman, Miriam

Published
2015

39. Maintenance treatment with capecitabine and bevacizumab in metastatic colorectal cancer (CAIRO3): a phase 3 randomised controlled trial of the Dutch Colorectal Cancer Group

Author

Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, MS Medische Oncologie, Simkens, Lieke H J, van Tinteren, Harm, May, Anne, ten Tije, Albert J, Creemers, Geert-Jan M, Loosveld, Olaf J L, de Jongh, Felix E, Erdkamp, Frans L G, Erjavec, Zoran, van der Torren, Adelheid M E, Tol, Jolien, Braun, Hans J J, Nieboer, Peter, van der Hoeven, Jacobus J M, Haasjes, Janny G, Jansen, Rob L H, Wals, Jaap, Cats, Annemieke, Derleyn, Veerle A, Honkoop, Aafke H, Mol, Linda, Punt, Cornelis J A, Koopman, Miriam, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, MS Medische Oncologie, Simkens, Lieke H J, van Tinteren, Harm, May, Anne, ten Tije, Albert J, Creemers, Geert-Jan M, Loosveld, Olaf J L, de Jongh, Felix E, Erdkamp, Frans L G, Erjavec, Zoran, van der Torren, Adelheid M E, Tol, Jolien, Braun, Hans J J, Nieboer, Peter, van der Hoeven, Jacobus J M, Haasjes, Janny G, Jansen, Rob L H, Wals, Jaap, Cats, Annemieke, Derleyn, Veerle A, Honkoop, Aafke H, Mol, Linda, Punt, Cornelis J A, and Koopman, Miriam

Published
2015

45. Maintenance treatment with capecitabine and bevacizumab versus observation after induction treatment with chemotherapy and bevacizumab in metastatic colorectal cancer (mCRC): The phase III CAIRO3 study of the Dutch Colorectal Cancer Group (DCCG).

Author

Koopman, Miriam, primary, Simkens, Lieke HJ, additional, Ten Tije, Albert J., additional, Creemers, Geert-Jan, additional, Loosveld, Olaf JL, additional, de Jongh, Felix E., additional, Erdkamp, Frans, additional, Erjavec, Zoran, additional, van der Torren, Adelheid ME, additional, Van der Hoeven, Jacobus JM, additional, Nieboer, Peter, additional, Braun, J. J., additional, Jansen, Rob L., additional, Haasjes, Janny G., additional, Cats, Annemieke, additional, Wals, Jacob J., additional, Mol, Linda, additional, Dalesio, Otilia, additional, van Tinteren, Harm, additional, and Punt, Cornelis J. A., additional

Published
2013
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46. Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to 5 Years after Diagnosis.

Author

Smit KC, Derksen JWG, Stellato RK, VAN Lanen AS, Wesselink E, Belt EJT, Balen MC, Coene PPLO, Dekker JWT, DE Groot JW, Haringhuizen AW, VAN Halteren HK, VAN Heek TT, Helgason HH, Hendriks MP, DE Hingh IHJT, Hoekstra R, Houtsma D, Janssen JJB, Kok N, Konsten JLM, Los M, Meijerink MR, Mekenkamp LJM, Peeters KCMJ, Polée MB, Rietbroek RC, Schiphorst AHW, Schrauwen RWM, Schreinemakers J, Sie MPS, Simkens L, Sonneveld EJA, Terheggen F, Iersel LV, Vles WJ, Wasowicz-Kemps DK, DE Wilt JHW, Kok DE, Winkels RM, Kampman E, VAN Duijnhoven FJB, Koopman M, and May AM

Subjects
Male, Humans, Female, Exercise, Cohort Studies, Fatigue, Quality of Life, Colorectal Neoplasms diagnosis
Abstract

Introduction: Physical activity (PA) is associated with higher quality of life and probably better prognosis among colorectal cancer (CRC) patients. This study focuses on determinants of PA among CRC patients from diagnosis until 5 yr postdiagnosis., Methods: Sociodemographic and disease-related factors of participants of two large CRC cohort studies were combined. Moderate-to-vigorous PA during sport and leisure time (MVPA-SL) was measured at diagnosis (T0) and 6, 12, 24, and 60 months (T6 to T60) postdiagnosis, using the SQUASH questionnaire. Mixed-effects models were performed to identify sociodemographic and disease-related determinants of MVPA-SL, separately for stage I-III colon (CC), stage I-III rectal cancer (RC), and stage IV CRC (T0 and T6 only). Associations were defined as consistently present when significant at ≥4 timepoints for the stage I-III subsets. MVPA-SL levels were compared with an age- and sex-matched sample of the general Dutch population., Results: In total, 2905 CC, 1459 RC and 436 stage IV CRC patients were included. Patients with higher fatigue scores, and women compared with men had consistently lower MVPA-SL levels over time, regardless of tumor type and stage. At T6, having a stoma was significantly associated with lower MVPA-SL among stage I-III RC patients. Systemic therapy and radiotherapy were not significantly associated with MVPA-SL changes at T6. Compared with the general population, MVPA-SL levels of CRC patients were lower at all timepoints, most notably at T6., Conclusions: Female sex and higher fatigue scores were consistent determinants of lower MVPA-SL levels among all CRC patients, and MVPA-SL levels were lowest at 6 months postdiagnosis. Our results can inform the design of intervention studies aimed at improving PA, and guide healthcare professionals in optimizing individualized support., (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Sports Medicine.)

Published
2024
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47. Survival of patients with deficient mismatch repair metastatic colorectal cancer in the pre-immunotherapy era.

Author

Wensink GE, Elferink MAG, May AM, Mol L, Hamers PAH, Bakker SD, Creemers GJ, de Groot JWB, de Klerk GJ, Haberkorn BCM, Haringhuizen AW, Hoekstra R, Hunting JCB, Kerver ED, Mathijssen-van Stein D, Polée MB, Pruijt JFM, Quarles van Ufford-Mannesse P, Radema S, Rietbroek RC, Simkens LHJ, Tanis BC, Ten Bokkel Huinink D, Tjin-A-Ton MLR, Tromp-van Driel CS, Troost MM, van de Wouw AJ, van den Berkmortel FWPJ, van der Pas AJM, van der Velden AMT, van Dijk MA, van Dodewaard-de Jong JM, van Druten EB, van Voorthuizen T, Jan Veldhuis G, Verheul HMW, Vestjens HJHMJ, Vincent J, Kranenburg OW, Punt CJA, Vink GR, Roodhart JML, and Koopman M

Subjects
Adult, Aged, Colorectal Neoplasms mortality, DNA Mismatch Repair, Female, Humans, Male, Middle Aged, Survival Analysis, Antineoplastic Agents therapeutic use, Colorectal Neoplasms drug therapy, Colorectal Neoplasms genetics, Microsatellite Instability
Abstract

Background: Metastatic colorectal cancer patients with deficient mismatch repair (dMMR mCRC) benefit from immunotherapy. Interpretation of the single-arm immunotherapy trials is complicated by insignificant survival data during systemic non-immunotherapy. We present survival data on a large, comprehensive cohort of dMMR mCRC patients, treated with or without systemic non-immunotherapy., Methods: Two hundred and eighty-one dMMR mCRC patients (n = 54 from three prospective Phase 3 CAIRO trials; n = 227 from the Netherlands Cancer Registry). Overall survival was analysed from diagnosis of mCRC (OS), from initiation of first-line (OS1) and second-line (OS2) systemic treatment. Cox regression analysis examined prognostic factors. As comparison for OS 2746 MMR proficient mCRC patients were identified., Results: Of 281 dMMR patients, 62% received first-line and 26% second-line treatment. Median OS was 16.0 months (13.8-19.6) with antitumour therapy and 2.5 months (1.8-3.5) in untreated patients. OS1 was 12.8 months (10.7-15.2) and OS2 6.2 months (5.4-8.9) in treated dMMR patients. Treated dMMR patients had a 7.6-month shorter median OS than pMMR patients., Conclusion: Available data from immunotherapy trials lack a control arm with standard systemic treatment. Given the poor outcome compared to the immunotherapy results, our data strongly suggest a survival benefit of immunotherapy in dMMR mCRC patients.

Published
2021
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48. Maintenance treatment in metastatic colorectal cancer.

Author

Simkens LH, van Tinteren H, Punt CJ, and Koopman M

Subjects
Female, Humans, Male, Angiogenesis Inhibitors therapeutic use, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Bevacizumab therapeutic use, Capecitabine therapeutic use, Colorectal Neoplasms drug therapy, Fluorouracil therapeutic use, Leucovorin therapeutic use, Maintenance Chemotherapy, Organoplatinum Compounds therapeutic use
Published
2015
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