26 results on '"Simell, Ville"'
Number of results to display per page
Search Results
2. Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort
- Author
-
Rewers, Marian, Bautista, Kimberly, Baxter, Judith, Bedoy, Ruth, Felipe-Morales, Daniel, Frohnert, Brigitte I., Gesualdo, Patricia, Hoffman, Michelle, Karban, Rachel, Liu, Edwin, Norris, Jill, Samper-Imaz, Adela, Steck, Andrea, Waugh, Kathleen, Wright, Hali, She, Jin-Xiong, Schatz, Desmond, Hopkins, Diane, Steed, Leigh, Thomas, Jamie, Adams, Janey, Silvis, Katherine, Haller, Michael, Gardiner, Melissa, McIndoe, Richard, Sharma, Ashok, Williams, Joshua, Foghis, Gabriela, Anderson, Stephen W., Robinson, Richard, Ziegler, Anette G., Beyerlein, Andreas, Bonifacio, Ezio, Hummel, Michael, Hummel, Sandra, Foterek, Kristina, Kersting, Mathilde, Knopff, Annette, Koletzko, Sibylle, Peplow, Claudia, Roth, Roswith, Stock, Joanna, Strauss, Elisabeth, Warncke, Katharina, Winkler, Christiane, Toppari, Jorma, Simell, Olli G., Adamsson, Annika, Hyöty, Heikki, Ilonen, Jorma, Jokipuu, Sanna, Kallio, Tiina, Kähönen, Miia, Knip, Mikael, Koivu, Annika, Koreasalo, Mirva, Kurppa, Kalle, Lönnrot, Maria, Mäntymäki, Elina, Multasuo, Katja, Mykkänen, Juha, Niininen, Tiina, Nyblom, Mia, Rajala, Petra, Rautanen, Jenna, Riikonen, Anne, Romo, Minna, Simell, Satu, Simell, Tuula, Simell, Ville, Sjöberg, Maija, Stenius, Aino, Särmä, Maria, Vainionpää, Sini, Varjonen, Eeva, Veijola, Riitta, Virtanen, Suvi M., Vähä-Mäkilä, Mari, Åkerlund, Mari, Lernmark, Åke, Agardh, Daniel, Aronsson, Carin Andrén, Ask, Maria, Bremer, Jenny, Carlsson, Ulla-Marie, Cilio, Corrado, Ericson-Hallström, Emelie, Fransson, Lina, Gard, Thomas, Gerardsson, Joanna, Bennet, Rasmus, Hansen, Monica, Hansson, Gertie, Harmby, Cecilia, Hyberg, Susanne, Johansen, Fredrik, Jonasdottir, Berglind, Larsson, Helena Elding, Forss, Sigrid Lenrick, Lundgren, Markus, Månsson-Martinez, Maria, Markan, Maria, Melin, Jessica, Mestan, Zeliha, Rahmati, Kobra, Ramelius, Anita, Rosenquist, Anna, Salami, Falastin, Sibthorpe, Sara, Sjöberg, Birgitta, Swartling, Ulrica, Amboh, Evelyn Tekum, Trulsson, Erika, Törn, Carina, Wallin, Anne, Wimar, Åsa, Åberg, Sofie, Hagopian, William A., Killian, Michael, Crouch, Claire Cowen, Skidmore, Jennifer, Ayres, Stephen, Dunson, Kayleen, Hervey, Rachel, Johnson, Corbin, Lyons, Rachel, Meyer, Arlene, Mulenga, Denise, Scott, Elizabeth, Stabbert, Joshua, Tarr, Alexander, Uland, Morgan, Willis, John, Becker, Dorothy, Franciscus, Margaret, Smith, MaryEllen Dalmagro-Elias, Daftary, Ashi, Klein, Mary Beth, Yates, Chrystal, Krischer, Jeffrey P., Abbondondolo, Michael, Austin-Gonzalez, Sarah, Baethke, Sandra, Brown, Rasheedah, Burkhardt, Brant, Butterworth, Martha, Clasen, Joanna, Cuthbertson, David, Eberhard, Christopher, Fiske, Steven, Garcia, Dena, Garmeson, Jennifer, Gowda, Veena, Heyman, Kathleen, Laras, Francisco Perez, Lee, Hye-Seung, Liu, Shu, Liu, Xiang, Lynch, Kristian, Malloy, Jamie, McCarthy, Cristina, McLeod, Wendy, Meulemans, Steven, Shaffer, Chris, Smith, Laura, Smith, Susan, Sulman, Noah, Tamura, Roy, Uusitalo, Ulla, Vehik, Kendra, Vijayakandipan, Ponni, Wood, Keith, Yang, Jimin, Ballard, Lori, Hadley, David, Akolkar, Beena, Bourcier, Kasia, Briese, Thomas, Johnson, Suzanne Bennett, Triplett, Eric, Andrén Aronsson, Carin, and Norris, Jill M.
- Published
- 2016
- Full Text
- View/download PDF
3. Joint modeling of longitudinal autoantibody patterns and progression to type 1 diabetes: results from the TEDDY study
- Author
-
Köhler, Meike, Beyerlein, Andreas, Vehik, Kendra, Greven, Sonja, Umlauf, Nikolaus, Lernmark, Åke, Hagopian, William A., Rewers, Marian, She, Jin-Xiong, Toppari, Jorma, Akolkar, Beena, Krischer, Jeffrey P., Bonifacio, Ezio, Ziegler, Anette-G., Rewers, Marian, Bautista, Kimberly, Baxter, Judith, Bedoy, Ruth, Felipe-Morales, Daniel, Driscoll, Kimberly, Frohnert, Brigitte I., Gesualdo, Patricia, Hoffman, Michelle, Karban, Rachel, Liu, Edwin, Norris, Jill, Samper-Imaz, Adela, Steck, Andrea, Waugh, Kathleen, Wright, Hali, Toppari, Jorma, Simell, Olli G., Adamsson, Annika, Ahonen, Suvi, Hyöty, Heikki, Ilonen, Jorma, Jokipuu, Sanna, Kallio, Tiina, Karlsson, Leena, Kähönen, Miia, Knip, Mikael, Kovanen, Lea, Koreasalo, Mirva, Kurppa, Kalle, Latva-aho, Tiina, Lönnrot, Maria, Mäntymäki, Elina, Multasuo, Katja, Mykkänen, Juha, Niininen, Tiina, Niinistö, Sari, Nyblom, Mia, Rajala, Petra, Rautanen, Jenna, Riikonen, Anne, Riikonen, Mika, Rouhiainen, Jenni, Romo, Minna, Simell, Tuula, Simell, Ville, Sjöberg, Maija, Stenius, Aino, Leppänen, Maria, Vainionpää, Sini, Varjonen, Eeva, Veijola, Riitta, Virtanen, Suvi M., Vähä-Mäkilä, Mari, Åkerlund, Mari, Lindfors, Katri, She, Jin-Xiong, Schatz, Desmond, Hopkins, Diane, Steed, Leigh, Thomas, Jamie, Adams, Janey, Silvis, Katherine, Haller, Michael, Gardiner, Melissa, McIndoe, Richard, Sharma, Ashok, Williams, Joshua, Young, Gabriela, Anderson, Stephen W., Jacobsen, Laura, Ziegler, Anette G., Beyerlein, Andreas, Bonifacio, Ezio, Hummel, Michael, Hummel, Sandra, Foterek, Kristina, Janz, Nicole, Kersting, Mathilde, Knopff, Annette, Koletzko, Sibylle, Peplow, Claudia, Roth, Roswith, Scholz, Marlon, Stock, Joanna, Warncke, Katharina, Wendel, Lorena, Winkler, Christiane, Lernmark, Åke, Agardh, Daniel, Aronsson, Carin Andrén, Ask, Maria, Bremer, Jenny, Carlsson, Ulla-Marie, Cilio, Corrado, Ericson-Hallström, Emelie, Fransson, Lina, Gard, Thomas, Gerardsson, Joanna, Bennet, Rasmus, Hansen, Monica, Hansson, Gertie, Hyberg, Susanne, Johansen, Fredrik, Jonsdottir, Berglind, Larsson, Helena Elding, Lindström, Marielle, Lundgren, Markus, Månsson-Martinez, Maria, Markan, Maria, Melin, Jessica, Mestan, Zeliha, Ottosson, Karin, Rahmati, Kobra, Ramelius, Anita, Salami, Falastin, Sibthorpe, Sara, Sjöberg, Birgitta, Swartling, Ulrica, Amboh, Evelyn Tekum, Törn, Carina, Wallin, Anne, Wimar, Åsa, Åberg, Sofie, Hagopian, William A., Killian, Michael, Crouch, Claire Cowen, Skidmore, Jennifer, Carson, Josephine, Dalzell, Maria, Dunson, Kayleen, Hervey, Rachel, Johnson, Corbin, Lyons, Rachel, Meyer, Arlene, Mulenga, Denise, Tarr, Alexander, Uland, Morgan, Willis, John, Becker, Dorothy, Franciscus, Margaret, Smith, MaryEllen Dalmagro-Elias, Daftary, Ashi, Klein, Mary Beth, Yates, Chrystal, Krischer, Jeffrey P., Abbondondolo, Michael, Austin-Gonzalez, Sarah, Avendano, Maryouri, Baethke, Sandra, Brown, Rasheedah, Burkhardt, Brant, Butterworth, Martha, Clasen, Joanna, Cuthbertson, David, Eberhard, Christopher, Fiske, Steven, Garcia, Dena, Garmeson, Jennifer, Gowda, Veena, Heyman, Kathleen, PerezLaras, Francisco, Lee, Hye-Seung, Liu, Shu, Liu, Xiang, Lynch, Kristian, Malloy, Jamie, McCarthy, Cristina, Meulemans, Steven, Parikh, Hemang, Shaffer, Chris, Smith, Laura, Smith, Susan, Sulman, Noah, Tamura, Roy, Uusitalo, Ulla, Vehik, Kendra, Vijayakandipan, Ponni, Wood, Keith, Yang, Jimin, Ballard, Lori, Hadley, David, McLeod, Wendy, Akolkar, Beena, Yu, Liping, Miao, Dongmei, Bingley, Polly, Williams, Alistair, Chandler, Kyla, Rokni, Saba, Williams, Claire, Wyatt, Rebecca, George, Gifty, Grace, Sian, Erlich, Henry, Mack, Steven J., Ke, Sandra, Mulholland, Niveen, Bourcier, Kasia, Briese, Thomas, Johnson, Suzanne Bennett, Triplett, Eric, TEDDY study group, Ancillary Studies, Diet, Genetics, Human Subjects/Publicity/Publications, Immune Markers, Infectious Agents, Laboratory Implementation, Maternal Studies, Psychosocial, Quality Assurance, Steering, Study Coordinators, Celiac Disease, Clinical Implementation, and Quality Assurance Subcommittee on Data Quality
- Published
- 2017
- Full Text
- View/download PDF
4. Cesarean Section on the Risk of Celiac Disease in the Offspring: The Teddy Study
- Author
-
Koletzko, Sibylle, Lee, Hye-Seung, Beyerlein, Andreas, Aronsson, Carin A., Hummel, Michael, Liu, Edwin, Simell, Ville, Kurppa, Kalle, Lernmark, Åke, Hagopian, William, Rewers, Marian, She, Jin-Xiong, Simell, Olli, Toppari, Jorma, Ziegler, Anette-G., Krischer, Jeffrey, and Agardh, Daniel
- Published
- 2018
- Full Text
- View/download PDF
5. Diagnostic methods for and clinical pictures of polyomavirus primary infections in children, Finland
- Author
-
Chen, Tingting, Tanner, Laura, Simell, Ville, Hedman, Lea, Makinen, Marjaana, Sadeghi, Mohammadreza, Veijola, Riitta, Hyoty, Heikki, Ilonen, Jorma, Knip, Mikael, Toppari, Jorma, Simell, Olli, Soderlund-Venermo, Maria, and Hedman, Klaus
- Subjects
Conjunctivitis -- Diagnosis -- Methods -- Health aspects ,Children -- Methods -- Health aspects ,Skin -- Methods -- Health aspects ,Immunoglobulin G -- Methods -- Health aspects ,Health - Abstract
Two novel human polyomaviruses can cause skin diseases that are predominant in immunosuppressed persons. Merkel cell polyomavirus (MCPyV) is associated with Merkel cell carcinoma, which is an uncommon aggressive skin [...]
- Published
- 2014
- Full Text
- View/download PDF
6. Serum 25-Hydroxyvitamin D Concentrations in Children Progressing to Autoimmunity and Clinical Type 1 Diabetes
- Author
-
Mäkinen, Marjaana, Mykkänen, Juha, Koskinen, Maarit, Simell, Ville, Veijola, Riitta, Hyöty, Heikki, Ilonen, Jorma, Knip, Mikael, Simell, Olli, and Toppari, Jorma
- Published
- 2016
7. Association of human bocavirus 1 infection with respiratory disease in childhood follow-up study, Finland
- Author
-
Meriluoto, Mira, Hedman, Lea, Tanner, Laura, Simell, Ville, Makinen, Marjaana, Simell, Satu, Mykkanen, Juha, Korpelainen, Jan, Ruuskanen, Olli, Ilonen, Jorma, Knip, Mikael, Simell, Olli, Hedman, Klaus, and Soderlund-Venermo, Maria
- Subjects
Medical research -- Health aspects ,Respiratory tract diseases -- Health aspects ,DNA -- Health aspects ,Viral antibodies -- Health aspects ,Infection in children -- Health aspects ,Infection -- Health aspects ,Immunoglobulin G -- Health aspects ,Children -- Diseases ,Medicine, Experimental -- Health aspects ,Lung diseases -- Health aspects ,Immunoglobulins -- Health aspects ,Conjunctivitis -- Health aspects ,Enzymes -- Health aspects ,Antibodies -- Health aspects ,Health - Abstract
Human bocavirus 1 (HBoV1), a new member of the Bocavirus genus of the family Parvoviridae, was discovered in 2005 by large-scale sequencing in nasopharyngeal samples from children (1). HBoV1 DNA [...]
- Published
- 2012
- Full Text
- View/download PDF
8. Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort
- Author
-
Aronsson, Carin Andrén, Lee, Hye-Seung, Koletzko, Sibylle, Uusitalo, Ulla, Yang, Jimin, Virtanen, Suvi M., Liu, Edwin, Lernmark, Åke, Norris, Jill M., Agardh, Daniel, Rewers, Marian, Bautista, Kimberly, Baxter, Judith, Bedoy, Ruth, Felipe-Morales, Daniel, Frohnert, Brigitte I., Gesualdo, Patricia, Hoffman, Michelle, Karban, Rachel, Liu, Edwin, Norris, Jill, Samper-Imaz, Adela, Steck, Andrea, Waugh, Kathleen, Wright, Hali, She, Jin-Xiong, Schatz, Desmond, Hopkins, Diane, Steed, Leigh, Thomas, Jamie, Adams, Janey, Silvis, Katherine, Haller, Michael, Gardiner, Melissa, McIndoe, Richard, Sharma, Ashok, Williams, Joshua, Foghis, Gabriela, Anderson, Stephen W., Robinson, Richard, Ziegler, Anette G., Beyerlein, Andreas, Bonifacio, Ezio, Hummel, Michael, Hummel, Sandra, Foterek, Kristina, Kersting, Mathilde, Knopff, Annette, Koletzko, Sibylle, Peplow, Claudia, Roth, Roswith, Stock, Joanna, Strauss, Elisabeth, Warncke, Katharina, Winkler, Christiane, Toppari, Jorma, Simell, Olli G., Adamsson, Annika, Hyöty, Heikki, Ilonen, Jorma, Jokipuu, Sanna, Kallio, Tiina, Kähönen, Miia, Knip, Mikael, Koivu, Annika, Koreasalo, Mirva, Kurppa, Kalle, Lönnrot, Maria, Mäntymäki, Elina, Multasuo, Katja, Mykkänen, Juha, Niininen, Tiina, Nyblom, Mia, Rajala, Petra, Rautanen, Jenna, Riikonen, Anne, Romo, Minna, Simell, Satu, Simell, Tuula, Simell, Ville, Sjöberg, Maija, Stenius, Aino, Särmä, Maria, Vainionpää, Sini, Varjonen, Eeva, Veijola, Riitta, Virtanen, Suvi M., Vähä-Mäkilä, Mari, Åkerlund, Mari, Lernmark, Åke, Agardh, Daniel, Ask, Maria, Bremer, Jenny, Carlsson, Ulla-Marie, Cilio, Corrado, Ericson-Hallström, Emelie, Fransson, Lina, Gard, Thomas, Gerardsson, Joanna, Bennet, Rasmus, Hansen, Monica, Hansson, Gertie, Harmby, Cecilia, Hyberg, Susanne, Johansen, Fredrik, Jonasdottir, Berglind, Larsson, Helena Elding, Forss, Sigrid Lenrick, Lundgren, Markus, Månsson-Martinez, Maria, Markan, Maria, Melin, Jessica, Mestan, Zeliha, Rahmati, Kobra, Ramelius, Anita, Rosenquist, Anna, Salami, Falastin, Sibthorpe, Sara, Sjöberg, Birgitta, Swartling, Ulrica, Amboh, Evelyn Tekum, Trulsson, Erika, Törn, Carina, Wallin, Anne, Wimar, Åsa, Åberg, Sofie, Hagopian, William A., Killian, Michael, Crouch, Claire Cowen, Skidmore, Jennifer, Ayres, Stephen, Dunson, Kayleen, Hervey, Rachel, Johnson, Corbin, Lyons, Rachel, Meyer, Arlene, Mulenga, Denise, Scott, Elizabeth, Stabbert, Joshua, Tarr, Alexander, Uland, Morgan, Willis, John, Becker, Dorothy, Franciscus, Margaret, Smith, MaryEllen Dalmagro-Elias, Daftary, Ashi, Klein, Mary Beth, Yates, Chrystal, Krischer, Jeffrey P., Abbondondolo, Michael, Austin-Gonzalez, Sarah, Baethke, Sandra, Brown, Rasheedah, Burkhardt, Brant, Butterworth, Martha, Clasen, Joanna, Cuthbertson, David, Eberhard, Christopher, Fiske, Steven, Garcia, Dena, Garmeson, Jennifer, Gowda, Veena, Heyman, Kathleen, Laras, Francisco Perez, Lee, Hye-Seung, Liu, Shu, Liu, Xiang, Lynch, Kristian, Malloy, Jamie, McCarthy, Cristina, McLeod, Wendy, Meulemans, Steven, Shaffer, Chris, Smith, Laura, Smith, Susan, Sulman, Noah, Tamura, Roy, Uusitalo, Ulla, Vehik, Kendra, Vijayakandipan, Ponni, Wood, Keith, Yang, Jimin, Ballard, Lori, Hadley, David, Akolkar, Beena, Bourcier, Kasia, Briese, Thomas, Johnson, Suzanne Bennett, and Triplett, Eric
- Published
- 2016
- Full Text
- View/download PDF
9. An Increase in Serum 25-Hydroxyvitamin D Concentrations Preceded a Plateau in Type 1 Diabetes Incidence in Finnish Children
- Author
-
Mäkinen, Marjaana, Simell, Ville, Mykkänen, Juha, Ilonen, Jorma, Veijola, Riitta, Hyöty, Heikki, Knip, Mikael, Simell, Olli, Toppari, Jorma, and Hermann, Robert
- Published
- 2014
10. Risk of Pediatric Celiac Disease According to HLA Haplotype and Country
- Author
-
Liu, Edwin, Lee, Hye-Seung, Aronsson, Carin A., Hagopian, William A., Koletzko, Sibylle, Rewers, Marian J., Eisenbarth, George S., Bingley, Polly J., Bonifacio, Ezio, Simell, Ville, and Agardh, Daniel
- Published
- 2014
- Full Text
- View/download PDF
11. Cord Serum Lipidome in Prediction of Islet Autoimmunity and Type 1 Diabetes
- Author
-
Orešič, Matej, Gopalacharyulu, Peddinti, Mykkänen, Juha, Lietzen, Niina, Mäkinen, Marjaana, Nygren, Heli, Simell, Satu, Simell, Ville, Hyöty, Heikki, Veijola, Riitta, Ilonen, Jorma, Sysi-Aho, Marko, Knip, Mikael, Hyötyläinen, Tuulia, and Simell, Olli
- Published
- 2013
- Full Text
- View/download PDF
12. Age at Development of Type 1 Diabetes– and Celiac Disease–Associated Antibodies and Clinical Disease in Genetically Susceptible Children Observed From Birth
- Author
-
Simell, Satu, Hoppu, Sanna, Simell, Tuu, Ståhlberg, Marja-Riitta, Viander, Markku, Routi, Taina, Simell, Ville, Veijola, Riitta, Ilonen, Jorma, Hyöty, Heikki, Knip, Mikael, and Simell, Olli
- Published
- 2010
- Full Text
- View/download PDF
13. Fate of Five Celiac Disease-Associated Antibodies During Normal Diet in Genetically At-Risk Children Observed from Birth in a Natural History Study
- Author
-
Simell, Satu, Hoppu, Sanna, Hekkala, Anne, Simell, Tuula, Ståhlberg, Marja-Riitta, Viander, Markku, Yrjänäinen, Heta, Grönlund, Juhani, Markula, Perttu, Simell, Ville, Knip, Mikael, Ilonen, Jorma, Hyöty, Heikki, and Simell, Olli
- Published
- 2007
14. Correction: B-Cell Responses to Human Bocaviruses 1–4: New Insights from a Childhood Follow-Up Study
- Author
-
Kantola, Kalle, primary, Hedman, Lea, additional, Tanner, Laura, additional, Simell, Ville, additional, Mäkinen, Marjaana, additional, Partanen, Juulia, additional, Sadeghi, Mohammadreza, additional, Veijola, Riitta, additional, Knip, Mikael, additional, Ilonen, Jorma, additional, Hyöty, Heikki, additional, Toppari, Jorma, additional, Simell, Olli, additional, Hedman, Klaus, additional, and Söderlund-Venermo, Maria, additional
- Published
- 2017
- Full Text
- View/download PDF
15. Correction: Vol. 18, No. 2
- Author
-
Meriluoto, Mira, Hedman, Lea, Tanner, Laura, Simell, Ville, Makinen, Marjaana, Simell, Satu, Mykkanen, Juha, Korpelainen, Jan, Ruuskanen, Olli, Ilonen, Jorma, Knip, Mikael, Simell, Olli, Hedman, Klaus, and Soderlund-Venermo, Maria
- Subjects
Health - Abstract
To the Editor: In our earlier assessment of the etiologic role of human bocavirus 1 (HBoVl) among 109 constitutionally healthy children, seroconversion measured by a standard IgG enzyme immunoassay (EIA) [...]
- Published
- 2016
16. Reduced beta-cell function in early preclinical type 1 diabetes
- Author
-
University of Helsinki, Clinicum, Koskinen, Maarit K., Helminen, Olli, Matomaki, Jaakko, Aspholm, Susanna, Mykkanen, Juha, Makinen, Marjaana, Simell, Ville, Vaha-Makila, Mari, Simell, Tuula, Ilonen, Jorma, Knip, Mikael, Veijola, Riitta, Toppari, Jorma, Simell, Olli, University of Helsinki, Clinicum, Koskinen, Maarit K., Helminen, Olli, Matomaki, Jaakko, Aspholm, Susanna, Mykkanen, Juha, Makinen, Marjaana, Simell, Ville, Vaha-Makila, Mari, Simell, Tuula, Ilonen, Jorma, Knip, Mikael, Veijola, Riitta, Toppari, Jorma, and Simell, Olli
- Abstract
Objective: We aimed to characterize insulin responses to i.v. glucose during the preclinical period of type 1 diabetes starting from the emergence of islet autoimmunity. Design and methods: A large population-based cohort of children with HLA-conferred susceptibility to type 1 diabetes was observed from birth. During regular follow-up visits islet autoantibodies were analysed. We compared markers of glucose metabolism in sequential intravenous glucose tolerance tests between 210 children who were positive for multiple (>= 2) islet autoantibodies and progressed to type 1 diabetes (progressors) and 192 children testing positive for classical islet-cell antibodies only and remained healthy (non-progressors). Results: In the progressors, the first phase insulin response (FPIR) was decreased as early as 4-6 years before the diagnosis when compared to the non-progressors (P=0.001). The difference in FPIR between the progressors and non-progressors was significant (P Conclusions: FPIR is decreased several years before the diagnosis of type 1 diabetes, implying an intrinsic defect in beta-cell mass and/or function.
- Published
- 2016
17. Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort
- Author
-
Andrén Aronsson, Carin, primary, Lee, Hye-Seung, additional, Koletzko, Sibylle, additional, Uusitalo, Ulla, additional, Yang, Jimin, additional, Virtanen, Suvi M., additional, Liu, Edwin, additional, Lernmark, Åke, additional, Norris, Jill M., additional, Agardh, Daniel, additional, Rewers, Marian, additional, Bautista, Kimberly, additional, Baxter, Judith, additional, Bedoy, Ruth, additional, Felipe-Morales, Daniel, additional, Frohnert, Brigitte I., additional, Gesualdo, Patricia, additional, Hoffman, Michelle, additional, Karban, Rachel, additional, Norris, Jill, additional, Samper-Imaz, Adela, additional, Steck, Andrea, additional, Waugh, Kathleen, additional, Wright, Hali, additional, She, Jin-Xiong, additional, Schatz, Desmond, additional, Hopkins, Diane, additional, Steed, Leigh, additional, Thomas, Jamie, additional, Adams, Janey, additional, Silvis, Katherine, additional, Haller, Michael, additional, Gardiner, Melissa, additional, McIndoe, Richard, additional, Sharma, Ashok, additional, Williams, Joshua, additional, Foghis, Gabriela, additional, Anderson, Stephen W., additional, Robinson, Richard, additional, Ziegler, Anette G., additional, Beyerlein, Andreas, additional, Bonifacio, Ezio, additional, Hummel, Michael, additional, Hummel, Sandra, additional, Foterek, Kristina, additional, Kersting, Mathilde, additional, Knopff, Annette, additional, Peplow, Claudia, additional, Roth, Roswith, additional, Stock, Joanna, additional, Strauss, Elisabeth, additional, Warncke, Katharina, additional, Winkler, Christiane, additional, Toppari, Jorma, additional, Simell, Olli G., additional, Adamsson, Annika, additional, Hyöty, Heikki, additional, Ilonen, Jorma, additional, Jokipuu, Sanna, additional, Kallio, Tiina, additional, Kähönen, Miia, additional, Knip, Mikael, additional, Koivu, Annika, additional, Koreasalo, Mirva, additional, Kurppa, Kalle, additional, Lönnrot, Maria, additional, Mäntymäki, Elina, additional, Multasuo, Katja, additional, Mykkänen, Juha, additional, Niininen, Tiina, additional, Nyblom, Mia, additional, Rajala, Petra, additional, Rautanen, Jenna, additional, Riikonen, Anne, additional, Romo, Minna, additional, Simell, Satu, additional, Simell, Tuula, additional, Simell, Ville, additional, Sjöberg, Maija, additional, Stenius, Aino, additional, Särmä, Maria, additional, Vainionpää, Sini, additional, Varjonen, Eeva, additional, Veijola, Riitta, additional, Vähä-Mäkilä, Mari, additional, Åkerlund, Mari, additional, Aronsson, Carin Andrén, additional, Ask, Maria, additional, Bremer, Jenny, additional, Carlsson, Ulla-Marie, additional, Cilio, Corrado, additional, Ericson-Hallström, Emelie, additional, Fransson, Lina, additional, Gard, Thomas, additional, Gerardsson, Joanna, additional, Bennet, Rasmus, additional, Hansen, Monica, additional, Hansson, Gertie, additional, Harmby, Cecilia, additional, Hyberg, Susanne, additional, Johansen, Fredrik, additional, Jonasdottir, Berglind, additional, Larsson, Helena Elding, additional, Forss, Sigrid Lenrick, additional, Lundgren, Markus, additional, Månsson-Martinez, Maria, additional, Markan, Maria, additional, Melin, Jessica, additional, Mestan, Zeliha, additional, Rahmati, Kobra, additional, Ramelius, Anita, additional, Rosenquist, Anna, additional, Salami, Falastin, additional, Sibthorpe, Sara, additional, Sjöberg, Birgitta, additional, Swartling, Ulrica, additional, Amboh, Evelyn Tekum, additional, Trulsson, Erika, additional, Törn, Carina, additional, Wallin, Anne, additional, Wimar, Åsa, additional, Åberg, Sofie, additional, Hagopian, William A., additional, Killian, Michael, additional, Crouch, Claire Cowen, additional, Skidmore, Jennifer, additional, Ayres, Stephen, additional, Dunson, Kayleen, additional, Hervey, Rachel, additional, Johnson, Corbin, additional, Lyons, Rachel, additional, Meyer, Arlene, additional, Mulenga, Denise, additional, Scott, Elizabeth, additional, Stabbert, Joshua, additional, Tarr, Alexander, additional, Uland, Morgan, additional, Willis, John, additional, Becker, Dorothy, additional, Franciscus, Margaret, additional, Smith, MaryEllen Dalmagro-Elias, additional, Daftary, Ashi, additional, Klein, Mary Beth, additional, Yates, Chrystal, additional, Krischer, Jeffrey P., additional, Abbondondolo, Michael, additional, Austin-Gonzalez, Sarah, additional, Baethke, Sandra, additional, Brown, Rasheedah, additional, Burkhardt, Brant, additional, Butterworth, Martha, additional, Clasen, Joanna, additional, Cuthbertson, David, additional, Eberhard, Christopher, additional, Fiske, Steven, additional, Garcia, Dena, additional, Garmeson, Jennifer, additional, Gowda, Veena, additional, Heyman, Kathleen, additional, Laras, Francisco Perez, additional, Liu, Shu, additional, Liu, Xiang, additional, Lynch, Kristian, additional, Malloy, Jamie, additional, McCarthy, Cristina, additional, McLeod, Wendy, additional, Meulemans, Steven, additional, Shaffer, Chris, additional, Smith, Laura, additional, Smith, Susan, additional, Sulman, Noah, additional, Tamura, Roy, additional, Vehik, Kendra, additional, Vijayakandipan, Ponni, additional, Wood, Keith, additional, Ballard, Lori, additional, Hadley, David, additional, Akolkar, Beena, additional, Bourcier, Kasia, additional, Briese, Thomas, additional, Johnson, Suzanne Bennett, additional, and Triplett, Eric, additional
- Published
- 2016
- Full Text
- View/download PDF
18. Reduced β-cell function in early preclinical type 1 diabetes
- Author
-
Koskinen, Maarit K, primary, Helminen, Olli, additional, Matomäki, Jaakko, additional, Aspholm, Susanna, additional, Mykkänen, Juha, additional, Mäkinen, Marjaana, additional, Simell, Ville, additional, Vähä-Mäkilä, Mari, additional, Simell, Tuula, additional, Ilonen, Jorma, additional, Knip, Mikael, additional, Veijola, Riitta, additional, Toppari, Jorma, additional, and Simell, Olli, additional
- Published
- 2016
- Full Text
- View/download PDF
19. B-Cell Responses to Human Bocaviruses 1–4: New Insights from a Childhood Follow-Up Study
- Author
-
Kantola, Kalle, primary, Hedman, Lea, additional, Tanner, Laura, additional, Simell, Ville, additional, Mäkinen, Marjaana, additional, Partanen, Juulia, additional, Sadeghi, Mohammadreza, additional, Veijola, Riitta, additional, Knip, Mikael, additional, Ilonen, Jorma, additional, Hyöty, Heikki, additional, Toppari, Jorma, additional, Simell, Olli, additional, Hedman, Klaus, additional, and Söderlund-Venermo, Maria, additional
- Published
- 2015
- Full Text
- View/download PDF
20. Antibodies to Deamidated Gliadin Peptide in Diagnosis of Celiac Disease in Children
- Author
-
Lammi, Anne, primary, Arikoski, Pekka, additional, Simell, Satu, additional, Kinnunen, Tuure, additional, Simell, Ville, additional, Paavanen-Huhtala, Sari, additional, Hinkkanen, Ari, additional, Veijola, Riitta, additional, Knip, Mikael, additional, Toppari, Jorma, additional, Vaarala, Outi, additional, Simell, Olli, additional, and Ilonen, Jorma, additional
- Published
- 2015
- Full Text
- View/download PDF
21. Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity.
- Author
-
Kemppainen, Kaisa M., Vehik, Kendra, Lynch, Kristian F., Larsson, Helena Elding, Canepa, Ronald J., Simell, Ville, Koletzko, Sibylle, Liu, Edwin, Simell, Olli G., Toppari, Jorma, Ziegler, Anette G., Rewers, Marian J., Lernmark, Åke, Hagopian, William A., Jin-Xiong She, Akolkar, Beena, Schatz, Desmond A., Atkinson, Mark A., Blaser, Martin J., and Krischer, Jeffrey P.
- Published
- 2017
- Full Text
- View/download PDF
22. Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes
- Author
-
Davis-Richardson, Austin G., primary, Ardissone, Alexandria N., additional, Dias, Raquel, additional, Simell, Ville, additional, Leonard, Michael T., additional, Kemppainen, Kaisa M., additional, Drew, Jennifer C., additional, Schatz, Desmond, additional, Atkinson, Mark A., additional, Kolaczkowski, Bryan, additional, Ilonen, Jorma, additional, Knip, Mikael, additional, Toppari, Jorma, additional, Nurminen, Noora, additional, Hyöty, Heikki, additional, Veijola, Riitta, additional, Simell, Tuula, additional, Mykkänen, Juha, additional, Simell, Olli, additional, and Triplett, Eric W., additional
- Published
- 2014
- Full Text
- View/download PDF
23. Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort.
- Author
-
Sharma, Ashok, Liu, Xiang, Hadley, David, Hagopian, William, Liu, Edwin, Chen, Wei-Min, Onengut-Gumuscu, Suna, Simell, Ville, Rewers, Marian, Ziegler, Anette-G., Lernmark, Åke, Simell, Olli, Toppari, Jorma, Krischer, Jeffrey P., Akolkar, Beena, Rich, Stephen S., Agardh, Daniel, She, Jin-Xiong, and null, null
- Subjects
CELIAC disease ,HLA histocompatibility antigens ,DISEASE incidence ,DISEASE prevalence ,AUTOANTIBODIES ,PEDIATRICS - Abstract
Objectives: There are significant geographical differences in the prevalence and incidence of celiac disease that cannot be explained by HLA alone. More than 40 loci outside of the HLA region have been associated with celiac disease. We investigated the roles of these non-HLA genes in the development of tissue transglutaminase autoantibodies (tTGA) and celiac disease in a large international prospective cohort study. Methods: A total of 424,788 newborns from the US and European general populations and first-degree relatives with type 1 diabetes were screened for specific HLA genotypes. Of these, 21,589 carried 1 of the 9 HLA genotypes associated with increased risk for type 1 diabetes and celiac disease; we followed 8676 of the children in a 15 y prospective follow-up study. Genotype analyses were performed on 6010 children using the Illumina ImmunoChip. Levels of tTGA were measured in serum samples using radio-ligand binding assays; diagnoses of celiac disease were made based on persistent detection of tTGA and biopsy analysis. Data were analyzed using Cox proportional hazards analyses. Results: We found 54 single-nucleotide polymorphisms (SNPs) in 5 genes associated with celiac disease (TAGAP, IL18R1, RGS21, PLEK, and CCR9) in time to celiac disease analyses (10
−4 >P>5.8x10−6 ). The hazard ratios (HR) for the SNPs with the smallest P values in each region were 1.59, 1.45, 2.23, 2.64, and 1.40, respectively. Outside of regions previously associated with celiac disease, we identified 10 SNPs in 8 regions that could also be associated with the disease (P<10−4 ). A SNP near PKIA (rs117128341, P = 6.5x10−8 , HR = 2.8) and a SNP near PFKFB3 (rs117139146, P<2.8x10−7 , HR = 4.9) reached the genome-wide association threshold in subjects from Sweden. Analyses of time to detection of tTGA identified 29 SNPs in 2 regions previously associated with celiac disease (CTLA4, P = 1.3x10−6 , HR = 0.76 and LPP, P = 2.8x10−5 , HR = .80) and 6 SNPs in 5 regions not previously associated with celiac disease (P<10−4 ); non-HLA genes are therefore involved in development of tTGA. Conclusions: In conclusion, using a genetic analysis of a large international cohort of children, we associated celiac disease development with 5 non-HLA regions previously associated with the disease and 8 regions not previously associated with celiac disease. We identified 5 regions associated with development of tTGA. Two loci associated with celiac disease progression reached a genome-wide association threshold in subjects from Sweden. [ABSTRACT FROM AUTHOR]- Published
- 2016
- Full Text
- View/download PDF
24. Diagnostic Methods for and Clinical Pictures of Polyomavirus Primary Infections in Children, Finland.
- Author
-
Tingting Chen, Tanner, Laura, Simell, Ville, Hedman, Lea, Mäkinen, Marjaana, Sadeghi, Mohammadreza, Veijola, Riitta, Hyöty, Heikki, Ilonen, Jorma, Knip, Mikael, Toppari, Jorma, Simell, Olli, Söderlund-Venermo, Maria, and Hedman, Klaus
- Subjects
SERODIAGNOSIS ,MERKEL cells ,POLYOMAVIRUSES ,POLYOMAVIRUS diseases ,INFECTION in children ,JUVENILE diseases - Abstract
We used comprehensive serodiagnostic methods (IgM, IgG, and IgG avidity) and PCR to study Merkel cell polyomavirus and trichodysplasia spinulosa-associated polyomavirus infections in children observed from infancy to adolescence. Comparing seroconversion intervals with previous and subsequent intervals, we found that primary infections with these 2 viruses were asymptomatic in childhood. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
25. Celiac Disease-Associated Antibodies in Children with Genetic Risk for both Type 1 Diabetes and Celiac Disease.
- Author
-
Simell, Satu, Hoppu, Sanna, Hekkala, Anne, Simell, Tuula, StÅhlberg, Marja-Riitta, Viander, Markku, Yrjänäinen, Heta, Grönlund, Juhani, Markula, Perttu, Simell, Ville, Knip, Mikael, Ilonen, Jorma, Hyöyy, Heikki, and Simell, Olli
- Subjects
CELIAC disease ,IMMUNOGLOBULINS ,CELIAC disease in children ,DIABETES in children ,TRANSGLUTAMINASES ,GLUTEN - Abstract
Because celiac disease (CD) is a common partner of type 1 diabetes (T1D), the two diseases may share pathways in pathogenesis. In T1D Prediction and Prevention Study (DIPP) we examined serum samples from over 2000 children with HLA-conferred genetic T1D and CD susceptibility, born between 11/1994 and 12/2002. The samples were collected at 3- to 12-month intervals and examined for antibodies to tissue transglutaminase (TGA). If positive, all previous and forthcoming samples were also examined for endomysium (EMA), reticulin (ARA) and gliadin antibodies (AGA-IgA,AGA-IgG). Eighty one (ca 4%) of the 2000 children were TGA-positive. AGA-IgG emerged first at age 2.2 ± 1.7; 0.5-7.5 years (mean ± SD; range). TGA, EMA and ARA emerged slightly later (TGA at 3.5±1.9; 1.0-9.0 years; p<0.001). Very few TGA-positive children had symptoms of CD; most were symptom-flee. Because a majority of serum samples was collected before this CD study began, the children were continuously exposed to gluten until TGA positivity was retrospectively discovered using biobanked serum samples. Despite continued gluten exposure TGA, EMA, ARA, AGA-IgA and AGA-IgG positivity disappeared spontaneously in 47%, 36%, 37, 43% and 29% of the children, respectively. CD was diagnosed in 42 of 53 TGA positive children whose parents consented to biopsy. In conclusion, potential non-gluten factor(s) regulating onset of CD autoimmunity probably function before AGA-IgG emerges. In a large proportion of children CD-associated antibodies disappear spontaneously suggesting that regulatory immune phenomena often extinguish incipient CD without exclusion of gluten from the diet. [ABSTRACT FROM AUTHOR]
- Published
- 2007
26. Clinical features of celiac disease: a prospective birth cohort.
- Author
-
Agardh D, Lee HS, Kurppa K, Simell V, Aronsson CA, Jörneus O, Hummel M, Liu E, and Koletzko S
- Subjects
- Adolescent, Biopsy, Celiac Disease genetics, Celiac Disease pathology, Child, Child, Preschool, Cohort Studies, Female, Genetic Predisposition to Disease genetics, Genotype, Humans, Infant, Infant, Newborn, Intestinal Mucosa pathology, Longitudinal Studies, Male, Prospective Studies, Risk Factors, Celiac Disease diagnosis
- Abstract
Objectives: To investigate clinical features of celiac disease (CD) and their association with risk factors for CD in a genetic risk birth cohort., Methods: Children from 6 clinical centers in 4 countries positive for HLA-DR3-DQ2 or DR4-DQ8 were annually screened for tissue transglutaminase antibodies (tTGA) and assessed for symptoms by questionnaires. Associations of symptoms with anthropometrics, known risk factors for CD, tTGA levels, and mucosal lesions in those biopsied were examined., Results: Of 6706 screened children, 914 developed persistent positive tTGA, 406 underwent biopsies, and 340 had CD. Compared with age-matched tTGA-negative children, those with persistent tTGA were more likely to have symptoms at 2 (34% vs 19%, P < .001) and 3 years of age (28% vs 19%, P = .009) but not at 4 years (27% vs 21%, NS). Z-scores for height, weight, and BMI did not differ between groups. In children with persistent tTGA, having ≥ 1 symptom was associated with family history of CD (odds ratio = 2.59, 95% confidence interval, 1.21-5.57) but not with age, gender, or HLA-DR3-DQ2 homozygosity. At seroconversion, tTGA levels were higher in symptomatic than asymptomatic children (P < .001), in those from CD families (P < .001), and in US participants (P < .001) but not associated with age, gender, or HLA genotype. tTGA levels correlated with severity of mucosal lesions both in symptomatic (r = 0.53, P < .001) and asymptomatic children (r = 0.22, P = .01)., Conclusions: A majority of children detected with persistent tTGA in screenings are asymptomatic and have normal growth by age 4 years. tTGA levels correlate more strongly with severity of mucosal lesions in symptomatic as compared with asymptomatic children., (Copyright © 2015 by the American Academy of Pediatrics.)
- Published
- 2015
- Full Text
- View/download PDF
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.