37 results on '"Silvio, Capizzi"'
Search Results
2. Lower probability and shorter duration of infections after COVID-19 vaccine correlate with anti-SARS-CoV-2 circulating IgGs
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Chiara Ronchini, Sara Gandini, Sebastiano Pasqualato, Luca Mazzarella, Federica Facciotti, Marina Mapelli, IEO Covid Team, Gianmaria Frige’, Rita Passerini, Luca Pase, Silvio Capizzi, Fabrizio Mastrilli, Roberto Orecchia, Gioacchino Natoli, and Pier Giuseppe Pelicci
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Medicine ,Science - Abstract
The correlation between immune responses and protection from SARS-CoV-2 infections and its duration remains unclear. We performed a sanitary surveillance at the European Institute of Oncology (IEO) in Milan over a 17 months period. Pre-vaccination, in 1,493 participants, we scored 266 infections (17.8%) and 8 possible reinfections (3%). Post-vaccination, we identified 30 infections in 2,029 vaccinated individuals (1.5%). We report that the probability of infection post-vaccination is i) significantly lower compared to natural infection, ii) associated with a significantly shorter median duration of infection than that of first infection and reinfection, iii) anticorrelated with circulating antibody levels.
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- 2022
3. COVID-19 and radiotherapy: impact on work and personal life of Lombardy residents during first lockdown, survey endorsed by AIRO Young
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Roberto Orecchia, Barbara Alicja Jereczek-Fossa, Gabriella Pravettoni, Isacco Desideri, Mattia Zaffaroni, Giulia Marvaso, Giulia Corrao, Fabrizio Mastrilli, Luca Bergamaschi, Silvio Capizzi, Daniela Alterio, and Iacopo Cavallo
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Cancer Research ,2019-20 coronavirus outbreak ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,SARS-CoV-2 ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,COVID-19 ,Personal life ,General Medicine ,030227 psychiatry ,03 medical and health sciences ,0302 clinical medicine ,Oncology ,Work (electrical) ,Surveys and Questionnaires ,030220 oncology & carcinogenesis ,Family medicine ,Communicable Disease Control ,Pandemic ,medicine ,Humans ,business ,Pandemics - Abstract
Aim: Since 20 February 2020, Lombardy has been one of the most affected areas worldwide by the coronavirus disease 2019 (COVID-19) pandemic. The aim of this study is to evaluate work and psychological impact of COVID-19 on Lombardy radiation therapy (RT) residents in the first 3 months of the outbreak (first lockdown). Methods: An online questionnaire (22 multiple choice questions) via Microsoft Forms was administered on 30 May 2020 to RT residents. Results: Nineteen Lombardy RT residents responded to the survey. Nineteen percent of residents underwent a nasal swab and 11% were quarantined. Seventeen residents (89%) reported an increase in workload. Twelve residents (63%) did not find any difference in terms of work distress; worsening was highlighted in 5 cases (26%). The majority has never considered the possibility of stopping work due to excessive stress (89%). Almost all the residents experienced self- or relative-referred apprehension (95%). Ninety-five percent reported having missed extra-work social relationships. Most of the sample noted worsening sleep quality and difficulty concentrating (69%). No residents requested psychological support, even if provided by the hospital. Conclusion: Overall, the residents adapted to the new workplace scenario, although some health risks and well-being challenges have been reported. An extension of the survey to all Italian RT residents endorsed by Italian Association of Radiotherapy and Clinical Oncology “Young AIRO” will allow an evaluation of COVID-19 impact on a national level. A second survey is planned to underline differences between the first lockdown and the current situation of the pandemic.
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- 2021
4. Are age and gender associated to tobacco use and knowledge among general practitioners?: Results of a survey in Italy
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Brigid Unim, Giuseppe Del Prete, Maria Rosaria Gualano, Silvio Capizzi, Walter Ricciardi, Antonio Boccia, and Giuseppe La Torre
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smoking ,cessation ,tobacco ,counseling ,general practitioner (GP) ,Public aspects of medicine ,RA1-1270 - Abstract
OBJECTIVES: The aim of this study was to assess knowledge and opinions of Italian general practitioners about the effectiveness of smoking cessation interventions and physicians' attitudes in addressing tobacco-related issues. METHODS: The survey was carried out through a questionnaire administered to general practitioners (GPs) attending a medical refresher course. 133 Italian GPs participated in the study with a mean age of 51.4 years (SD = 6.2). RESULTS: The GPs had good knowledge about the predictors of smoking onset, pharmacotherapies for tobacco cessation and the clinical guidelines recommendations. Wrong answers were encountered for the prevalence of smokers in Italy, the Fagerstrom Test for nicotine dependence and minimal advice. Females were more subjected to higher knowledge about tobacco, and at lower risk to be a smoker/ex smoker. Furthermore, physicians > 50 years old living in northern Italy had higher knowledge score. CONCLUSIONS: Physician education on tobacco counseling is associated to increased comfort and practice in advising patients who smoke. Tobacco cessation training might increase the success rate of helping patients to quit smoking.
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- 2013
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5. Lower probability and shorter duration of infections after COVID-19 vaccine correlate with anti-SARS-CoV-2 circulating IgGs
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Gianmaria Frigè, Sebastiano Pasqualato, Sara Gandini, Ieo Covid Team, Luca Mazzarella, Silvio Capizzi, Luca Pase, Fabrizio Mastrilli, Marina Mapelli, Gioacchino Natoli, Federica Facciotti, Pier Giuseppe Pelicci, Chiara Ronchini, Roberto Orecchia, Rita Passerini, Ronchini, C, Gandini, S, Pasqualato, S, Mazzarella, L, Facciotti, F, Mapelli, M, Frige', G, Passerini, R, Pase, L, Capizzi, S, Mastrilli, F, Orecchia, R, Natoli, G, and Pelicci, P
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Male ,RNA viruses ,Viral Diseases ,Time Factors ,Coronaviruses ,Physiology ,Antibodies, Viral ,Biochemistry ,Medical Conditions ,Immune Physiology ,Medicine ,Public and Occupational Health ,Pathology and laboratory medicine ,Virus Testing ,Aged, 80 and over ,Vaccines ,Multidisciplinary ,Immune System Proteins ,Middle Aged ,Medical microbiology ,Vaccination and Immunization ,Antibodies, Anti-Idiotypic ,Body Fluids ,Infectious Diseases ,Viruses ,Female ,SARS CoV 2 ,Pathogens ,Anatomy ,Research Article ,Adult ,2019-20 coronavirus outbreak ,COVID-19, SARS-CoV2, IgG, antibodies ,COVID-19 Vaccines ,Coronavirus disease 2019 (COVID-19) ,SARS coronavirus ,Infectious Disease Control ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Science ,Immunology ,Antibody level ,Mass Vaccination ,Microbiology ,Antibodies ,Young Adult ,Immune system ,Diagnostic Medicine ,Virology ,Humans ,Saliva ,Aged ,Medicine and health sciences ,Biology and life sciences ,business.industry ,SARS-CoV-2 ,Organisms ,Viral pathogens ,COVID-19 ,Proteins ,Viral Vaccines ,Covid 19 ,Microbial pathogens ,Immunoglobulin G ,Preventive Medicine ,business - Abstract
The correlation between immune responses and protection from SARS-CoV-2 infections and its duration remains unclear. We performed a sanitary surveillance at the European Institute of Oncology (IEO) in Milan over a 17 months period. Pre-vaccination, in 1,493 participants, we scored 266 infections (17.8%) and 8 possible reinfections (3%). Post-vaccination, we identified 30 infections in 2,029 vaccinated individuals (1.5%). We report that the probability of infection post-vaccination is i) significantly lower compared to natural infection, ii) associated with a significantly shorter median duration of infection than that of first infection and reinfection, iii) anticorrelated with circulating antibody levels.
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- 2022
6. The Prevention of Postmenopausal Osteoporotic Fractures: Results of the Health Technology Assessment of a New Antiosteoporotic Drug
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Maria Rosaria Gualano, Silvio Capizzi, Maria Lucia Specchia, Giuseppe La Torre, Chiara Cadeddu, Maria Luisa Di Pietro, Walter Ricciardi, Nicola Nicolotti, S Capri, Antonella Sferrazza, Flavia Kheiraoui, Maria Assunta Veneziano, and Chiara De Waure
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Budgets ,Genetics and Molecular Biology (all) ,Drug ,medicine.medical_specialty ,Technology Assessment, Biomedical ,Article Subject ,Immunology and Microbiology (all) ,Cost-Benefit Analysis ,media_common.quotation_subject ,Osteoporosis ,MEDLINE ,lcsh:Medicine ,Antibodies, Monoclonal, Humanized ,Biochemistry ,General Biochemistry, Genetics and Molecular Biology ,Strontium ranelate ,Epidemiology ,Biochemistry, Genetics and Molecular Biology (all) ,medicine ,Humans ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,Aged ,media_common ,Aged, 80 and over ,Bone Density Conservation Agents ,General Immunology and Microbiology ,Cost–benefit analysis ,business.industry ,lcsh:R ,Health Technology Assessment ,Health technology ,General Medicine ,Middle Aged ,medicine.disease ,Markov Chains ,Surgery ,Hospitalization ,Postmenopause ,Treatment Outcome ,Denosumab ,Italy ,Physical therapy ,Female ,business ,Osteoporotic Fractures ,Research Article ,medicine.drug - Abstract
Objective. The Health Technology Assessment (HTA) approach was applied to denosumab in the prevention of osteoporotic fractures in postmenopausal women.Method. Epidemiological, clinical, technical, economic, organizational, and ethical aspects were considered. Medical electronic databases were accessed to evaluate osteoporosis epidemiology and therapeutical approaches. A budget impact and a cost-effectiveness analyses were performed to assess economic implications. Clinical benefits and patient needs were considered with respect to organizational and ethical evaluation.Results. In Italy around four millions women are affected by osteoporosis and have a higher risk for fractures with 70,000 women being hospitalized every year. Bisphosphonates and strontium ranelate are recommended as first line treatment for the prevention of osteoporotic fractures. Denosumab is effective in reducing vertebral, nonvertebral, and hip/femoral fractures with an advantage of being administered subcutaneously every six months. The budget impact analysis estimated a reduction in costs for the National Health Service with the introduction of denosumab. Furthermore, the economic analysis demonstrated that denosumab is cost-effective in comparison to oral bisphosphonates and strontium ranelate. Denosumab can be administered in outpatients by involving General Practitioners in the management. Ethical evaluation is positive because of its efficacy and compliance.Conclusion. Denosumab could add value in the prevention of osteoporotic fractures.
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- 2014
7. Planning,budgeting and control systems,and management strategies of inputs in lean hospitals: literature review and potentialities of HTA
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Rosaria, Gualano Maria, Lovato, Emanuela, Bert, Fabrizio, Camussi, Elisa, Silvio, Capizzi, Andrea, Poscia, Brescia, Valerio, Eugenio, Anessi Pessina, Michela, Gianino Maria, and Siliquini, Roberta
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Intensity of care ,management strategies ,Health Technology Assessment - Published
- 2016
8. Economic value of influenza vaccination
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Chiara Cadeddu, Maria Lucia Specchia, S Capri, Walter Ricciardi, Silvio Capizzi, Chiara De Waure, and Maria Assunta Veneziano
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Adult ,Male ,Risk ,Adolescent ,Cost effectiveness ,Cost-Benefit Analysis ,Immunology ,Psychological intervention ,MEDLINE ,Young Adult ,Pregnancy ,Environmental health ,Influenza, Human ,Humans ,Immunology and Allergy ,Medicine ,Pregnancy Complications, Infectious ,Young adult ,Child ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,Aged ,Pharmacology ,Cost–benefit analysis ,business.industry ,Vaccination ,Infant ,Middle Aged ,Economic evaluation ,Influenza ,Checklist ,Europe ,Influenza Vaccines ,Child, Preschool ,Female ,business ,Vaccine - Abstract
Influenza epidemics are responsible for high mortality and morbidity rates in particular among elderly and high risk groups. This review is aimed at assessing the economic value of vaccination in these groups. A search of full economic evaluations of influenza vaccination in comparison with no interventions was performed on PubMed from January 1990 to May 2011. Only economic evaluations dealing with elderly and high risk groups were considered. The quality of selected articles was assessed through Drummond's checklist. Sixteen cost-effectiveness analyses and four cost-benefit analyses were included: overall, the quality of studies was fairly good. The vaccination was demonstrated to be cost-effective or cost-saving in almost all studies, independently by the perspective and the type of analysis. Influenza vaccination is a worthwhile intervention from the pharmacoeconomic view-point, anyway a standardization of methods should be desirable in order to guarantee the comparability and transferability of results.
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- 2012
9. [Burden of medical errors in Italy: an analysis of the literature]
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Maria Lucia, Specchia, Chiara, Cadeddu, Emanuela, Lovato, Silvio, Capizzi, Anna Maria, Ferriero, Marina, Veneziano, Agostino, Mancuso, and Walter, Ricciardi
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Evidence-Based Medicine ,Italy ,Medical Errors ,General Surgery ,Malpractice ,Cardiology ,Humans ,Patient Safety ,Laboratories, Hospital ,Radiology ,Quality of Health Care - Abstract
Medical malpractice and litigation have a significant impact on the Italian National Health Service. The aim of this study was to analyze the state of the art of medical errors in Italy, in particular, assessing which specialties are most affected.We performed a literature search in PubMed, Google Scholar; institutional websites (Ministry of Health, Higher Institute of Health, National Agency for Regional Health Services, National Institute of Statistics, National Research Council, Court of Auditors), gray literature and specialized magazines.Results show that data regarding the frequency of medical errors and the effectiveness of prevention measures in Italy are scarce. Most papers published on this topic refer to a few specialties, including Surgery, Radiology, Cardiology, and Laboratory medicine. Surgery is the specialty most affected.Despite a growing attention towards patient safety and quality of healthcare, medical errors continue to occur in clinical practice. Most errors are not due to individual incompetence or negligence but they are rooted in system breakdowns. A systematic approach is therefore required, based on: an analysis of critical aspects in the system; the selection and implementation, at different levels of the system, of appropriate and evidence-based risk management interventions involving all stakeholders; a context analysis to identify barriers and facilitators for change; a performance assessment to verify results and identify actions for improvement.
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- 2015
10. Economic impact of childhood obesity on health systems: a systematic review
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Agostino Mancuso, S Bucci, Maria Lucia Specchia, AG de Belvis, Walter Ricciardi, Silvio Capizzi, Ferruccio Pelone, and Maria Assunta Veneziano
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Gerontology ,business.industry ,Endocrinology, Diabetes and Metabolism ,media_common.quotation_subject ,Public Health, Environmental and Occupational Health ,Overweight ,medicine.disease ,Checklist ,Childhood obesity ,Environmental health ,Health care ,Medicine ,Quality (business) ,Economic impact analysis ,Medical journal ,medicine.symptom ,business ,Healthcare system ,media_common - Abstract
Summary The primary purpose of this study is to analyse the costs related to childhood obesity (CO) with reference to different models of healthcare systems. A systematic review of the economic impact of CO on healthcare systems was conducted by searching the main electronic scientific databases. Cost-of-illness (COI) analyses of children aged under 18 years who had been diagnosed as overweight or obese published up to July 2010 were considered. Short- and long-term consequences of CO were taken into account. In order to appraise the quality of the included studies, the British Medical Journal referees' checklist was used. About 3,844 COI analyses were initially found and 10 were finally considered in the current review: two studies referred to Beveridge and eight referred to Voluntary health insurance models. No studies have been conducted within a Bismarck model. Six studies considered in-patient costs, four studies estimated outpatient and primary care costs and seven studies considered pharmaceutical costs. The average quality of the included analyses was medium. The analysis confirmed the significance of CO related costs and the heterogeneity among available studies, which made it impossible to compare the different healthcare models.
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- 2011
11. Tobacco use prevalence, knowledge and attitudes among Italian hospital healthcare professionals
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Giuseppe La Torre, Roberto Bucci, Walter Ricciardi, Roberta Siliquini, Giorgio Liguori, Giuseppe Michele Masanotti, Chiara De Waure, Maria Giovanna Ficarra, Antonino Parlato, Silvio Capizzi, Lamberto Briziarelli, Lamberto Manzoli, Simone Chiadò Piat, Maria Rosaria Gualano, and Pasquale Cuccurullo
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Adult ,Male ,Health Knowledge, Attitudes, Practice ,medicine.medical_specialty ,Multivariate analysis ,Cross-sectional study ,Health Behavior ,education ,Population ,Psychological intervention ,Socio-culturale ,health personnel ,tobacco smoking ,prevalence ,tobacco ,Public health professionals ,Nursing ,Health care ,Personnel ,Prevalence ,Humans ,Medicine ,hospital ,health professional ,Practice ,education.field_of_study ,business.industry ,Health Knowledge ,Smoking ,Tobacco use ,Public Health, Environmental and Occupational Health ,Odds ratio ,Adult, Cross-Sectional Studies, Female, Health Behavior, Health Knowledge ,Attitudes ,Practice, Humans, Italy ,epidemiology, Male, Personnel ,Hospital, Prevalence, Smoking ,epidemiology, Socioeconomic Factors ,Confidence interval ,Personnel, Hospital ,Cross-Sectional Studies ,Health promotion ,Italy ,Socioeconomic Factors ,Family medicine ,epidemiology ,Female ,business - Abstract
Background: Healthcare professionals play a key role in tobacco use prevention because they are considered as model by patients. This multicenter study was aimed to evaluate smoking prevalence, knowledge and attitudes towards tobacco among Italian hospital professionals. Methods: A crosssectional study was carried out using a questionnaire administered to healthcare professionals in seven Italian hospitals, to investigate personal and occupational data, knowledge, attitudes, job setting, clinical activities, smoking habits and pattern for current smokers. Potential predictors of current smoking habits were evaluated using multiple logistic regressions. Results: Sample population was comprised of 1082 health professionals (51.4% females; mean age was 37.3 years: 25.3% were nurses, 24.5% medical doctors, 17.1% students and 33.1% other healthcare workers). Smoking prevalence was 44%. Among responders, 67.7% considered healthcare professional as a model for citizens, 90.5% declared to see colleagues smoking cigarettes inside the hospital (47.4% in the dependents’ toilets, 33.4% in the department kitchens and 4.7% in the patient room). Multivariate analysis showed that healthcare professionals working in Naples had a higher risk to be smokers in comparison to Rome [odds ratio (OR) = 2.29; 95% confidence interval (CI) 1.40–3.73]. Compared to medical doctors, post-graduate students (OR = 3.42; 95% CI: 1.81–6.44), nurses (OR = 2.48; 95% CI 1.51–4.08), nursing students (OR = 1.91; 95% CI 1.08–3.38) and auxiliary personnel (OR = 2.72; 95% CI 1.51–4.88), showed a higher likelihood of smoking. Conclusions: Among Italian hospital personnel there is a paradoxically large prevalence of smokers, higher than in the general population. Interventions aimed for the development of an adequate culture of health promotion, among these professionals, are urgently needed.
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- 2010
12. Does Quality of Observational Studies Affect the Results of a Meta-Analysis?
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Giuseppe La Torre, Silvio Capizzi, Gennaro Clemente, Nicola Nicolotti, Antonella Bilotta, Walter Ricciardi, Chiara De Waure, and Maria Lucia Specchia
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medicine.medical_specialty ,Epidemiology ,Endocrinology, Diabetes and Metabolism ,Cancer of pancreas ,Cohort Studies ,Endocrinology ,Cigarette smoking ,Risk Factors ,Internal medicine ,Internal Medicine ,Humans ,Medicine ,Risk factor ,Observational studies ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,Hepatology ,business.industry ,Smoking ,Case-control study ,Odds ratio ,Confidence interval ,Surgery ,Pancreatic Neoplasms ,Meta-analysis ,Case-Control Studies ,Relative risk ,business ,Cohort study - Abstract
OBJECTIVES A meta-analysis of observational studies on association between cigarette smoking and pancreatic cancer was performed to focus, particularly, on the role of the studies' quality in affecting meta-analysis results. METHODS A bibliographic search was carried out on PubMed and EMBASE databases until February 15, 2008. Key words were "pancreatic neoplasms," "pancreatic cancer," "smoking," "smoke," "cigarette," "case-control studies," and "cohort studies." Studies about cigarette smoking and pancreatic cancer were selected and assessed on quality. STATA 9.0 was used. RESULTS Six cohort studies and 24 case-control studies were selected, with median quality scores of 8 (range, 3) and 10 (range, 8), respectively. Pooled case-control studies' odds ratio (OR) and cohort studies' risk ratio were, respectively, 1.45 (95% confidence interval [CI], 1.33-1.57) and 1.78 (95% CI, 1.64-1.92). After stratifying for quality scoring, high-quality-scored case-control studies yielded an OR of 1.38 (95% CI, 1.27-1.49), whereas the others gave an OR of 1.52 (95% CI, 1.34-1.73). The results of meta-analysis for cohort studies showed a risk ratio of 1.74 (95% CI, 1.61-1.90) and of 2.10 (95% CI, 1.64-2.67), respectively, for high- and low-quality score studies. CONCLUSIONS There is evidence that cigarette smoking is an important risk factor for pancreatic cancer, but the estimate of the association greatly relies on the studies' quality.
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- 2009
13. Defensive medicine in Europe: which solutions?
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Gianfranco Damiani, Silvio Capizzi, Anna Maria Ferriero, Gualtiero Ricciardi, Maria Lucia Specchia, and Vincenzo Di Gregorio
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medicine.medical_specialty ,defensive medicine ,business.industry ,Public Health, Environmental and Occupational Health ,Alternative medicine ,medicine ,Criminology ,business ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,Defensive medicine - Published
- 2015
14. Effectiveness of 7-valent pneumococcal conjugate vaccine: A meta-analysis of post-marketing studies
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Milos Dujovic, Silvio Capizzi, Mufida Aljicevic, Chiara De Waure, Walter Ricciardi, Admir Malaj, and Maria Lucia Specchia
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pneumococcal vaccine ,business.industry ,Effectiveness ,complex mixtures ,Virology ,Pneumococcal conjugate vaccine ,stomatognathic system ,Meta-analysis ,otorhinolaryngologic diseases ,medicine ,business ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,health care economics and organizations ,medicine.drug - Abstract
Effectiveness of 7-valent pneumococcal conjugate vaccine: A meta-analysis of post-marketing studies
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- 2015
15. Global Burden and Health Trends of Non-Communicable Diseases
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Chiara De Waure, Silvio Capizzi, and Stefania Boccia
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medicine.medical_specialty ,business.industry ,Metabolic risk ,Burden of disease ,Communicable diseases ,Overweight ,medicine.disease ,Obesity ,Epidemiology ,Medicine ,Raised blood pressure ,medicine.symptom ,business ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,Demography - Abstract
Non-communicable diseases (NCD) are the biggest global killers today. More than 60 % of all deaths are caused by NCDs and nearly 80 % of these deaths occur in low- and middle-income countries, where the highest proportion of deaths under the age of 60 from NCDs occur. A large percentage of NCDs are preventable through the reduction of main behavioural (tobacco, alcohol, unhealthy diet, physical inactivity) and metabolic risk factors (raised cholesterol, raised blood pressure, overweight and obesity) .
- Published
- 2015
16. Knowledge, opinions and attitudes of Italian mothers towards HPV vaccination and Pap test
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Mauro Bergamini, Clara Ferrara, Maria Grazia Laura Marsala, Silvio Capizzi, Alberto Firenze, Brigid Unim, Maria Ferrara, Elisabetta De Vito, Silvia Miccoli, Rosella Saulle, Leda Semyonov, Valentina Bonanno, Giulio de Belvis, G Giraldi, Giuseppe La Torre, Pasquale Gregorio, Rosaria Nardella, Silvia Lupi, Enrica Guidi, Elisa Langiano, Maria Giovanna Ficarra, Antonio Boccia, La Torre, G., De Vito, E., Ficarra, M., Firenze, A., Gregorio, P., Miccoli, S., Giraldi, G., Unim, B., De Belvis, G., Boccia, A., Saulle, R., Semyonov, L., Ferrara, M., Langiano, E., Capizzi, S., Nardella, R., Marsala, M., Bonanno, V., Ferrara, C., Guidi, E., Bergamini, M., and Lupi, S.
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Questionnaires ,Uterine Cervical Neoplasm ,Health Knowledge, Attitudes, Practice ,Cancer Research ,Uterine Cervical Neoplasms ,Surveys and Questionnaires ,Surveys and Questionnaire ,Child ,Papillomavirus Vaccine ,Cervical cancer ,Univariate analysis ,Practice ,Mother ,medicine.diagnostic_test ,Health Knowledge ,Medicine (all) ,Vaccination ,Hpv vaccination ,General Medicine ,Middle Aged ,Pap-test ,Italy ,Oncology ,Female ,Human ,Papanicolaou Test ,Adult ,medicine.medical_specialty ,Human papillomavirus ,Adolescent ,Public health interventions ,Socio-culturale ,Mothers ,Judgment ,medicine ,Sexually transmitted infections ,Humans ,Pap test ,Papillomavirus Vaccines ,Papillomavirus Infections ,Self Report ,Papillomavirus Infection ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,Gynecology ,Sexually transmitted infection ,business.industry ,human papillomavirus ,mothers ,pap-test ,sexually transmitted infections ,vaccination ,medicine.disease ,Sexual intercourse ,Human papillomaviru ,Multicenter study ,Family medicine ,Attitudes ,business - Abstract
Aim This study evaluated the knowledge and attitudes of Italian mothers – whose daughters had been vaccinated in 2012 – towards primary (anti-HPV vaccination) and secondary (Pap test screening) cervical cancer prevention, as well as sources of information and mother-daughter communication on health issues. Methods The survey – part of a multicenter study carried out in 4 Italian cities (Ferrara, Rome, Cassino and Palermo) – was conducted through self-administered questionnaires. The first univariate analysis evaluated differences between mothers of under-18s and over-18s relative to knowledge and attitudes on HPV vaccination and Pap test. The second univariate analysis evaluated differences between the 2 groups of mothers and possible geographical variations regarding the sources of information on HPV and Pap test. Results The sample proved knowledgeable about the correlation between HPV and cervical cancer (>85%) but less aware of other HPV-related diseases. HPV vaccination should be administered before first sexual intercourse according to mothers of over-18s, and to 14- to 17-year-olds according to mothers of under-18s. Up to 88% of mothers of under-18s and 80% of mothers of over-18s declared that the vaccine should be given free of charge. More mothers of under-18s consulted a general practitioner (GP) or gynecologist before deciding to vaccinate their daughters. Mothers of under-18s received information on HPV vaccination mainly from GPs and gynecologists, while mothers of over-18s were informed through TV and books/journals. Over 80% of the sample declared satisfaction with the information received from their gynecologist during the Pap test. Conclusions The findings provide useful information for the development of effective public health interventions that may help improve acceptance of HPV vaccination among mothers.
- Published
- 2015
17. Economic burden of schizophrenia: the European situation. A scientific literature review
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Agostino Mancuso, Silvio Capizzi, Maria Lucia Specchia, Chiara Cadeddu, E Lovato, Anna Maria Ferriero, Walter Ricciardi, and C Marone
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Burden of disease ,medicine.medical_specialty ,business.industry ,Public health ,Schizophrenia (object-oriented programming) ,Public Health, Environmental and Occupational Health ,Prevalence ,Medicine ,Scientific literature ,business ,Psychiatry ,Economic consequences ,Schizophrenic disorders - Abstract
Background Schizophrenic disorders represent one of the most common public health issues in psychiatry. An estimated 4 million people in Europe suffer from schizophrenia. The European Burden of Disease Report quotes a point prevalence of 0.25-0.56% for schizophrenia. This disorder has been demonstrated to have important social and economic consequences, so it is necessary to assess its economic burden. The aim of this study was to analyze the costs related to …
- Published
- 2014
18. Health Technology Assessment of Belimumab: A New Monoclonal Antibody for the Treatment of Systemic Lupus Erythematosus
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Maria Lucia Specchia, Silvio Capizzi, Nicola Nicolotti, Maria Assunta Veneziano, F. Pierotti, Chiara Cadeddu, Antonella Sferrazza, Giuseppe Turchetti, Andrea Doria, R. Porcasi, Lara Pippo, Maria Luisa Di Pietro, Giuseppe La Torre, Daniela Gliubizzi, Luca Iaccarino, Francesco Di Nardo, Chiara De Waure, Ilaria Palla, Flavia Kheiraoui, Walter Ricciardi, and Maria Rosaria Gualano
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Adult ,Male ,medicine.medical_specialty ,Article Subject ,Cost-Benefit Analysis ,MEDLINE ,Lupus ,lcsh:Medicine ,Disease ,Antibodies, Monoclonal, Humanized ,General Biochemistry, Genetics and Molecular Biology ,Quality of life ,Epidemiology ,medicine ,Humans ,Lupus Erythematosus, Systemic ,Intensive care medicine ,skin and connective tissue diseases ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,Systemic lupus erythematosus ,Lupus erythematosus ,General Immunology and Microbiology ,business.industry ,lcsh:R ,HTA ,General Medicine ,medicine.disease ,Belimumab ,Quality-adjusted life year ,Italy ,Immunology ,Quality of Life ,Female ,business ,Immunosuppressive Agents ,Research Article ,medicine.drug - Abstract
Objective.Systemic lupus erythematosus (SLE) is treated with anti-inflammatory and immunosuppressive drugs and off-label biologics. Belimumab is the first biologic approved after 50 years as an add-on therapy for active disease. This paper summarizes a health technology assessment performed in Italy.Methods.SLE epidemiology and burden were assessed using the best published international and national evidences and efficacy and safety of belimumab were synthesized using clinical data. A cost-effectiveness analysis was performed by a lifetime microsimulation model comparing belimumab to standard of care (SoC). Organizational and ethical implications were discussed.Results.Literature review showed that SLE affects 47 per 100,000 people for a total of 28,500 patients in Italy, 50% of whom are affected by active form of the disease despite SoC. These patients, if autoantibodies and anti-dsDNA positive with low complement, are eligible for belimumab. SLE determines work disability and a 2–5-fold increase in mortality. Belimumab with SoC may prevent 4,742 flares in three years being cost-effective with an incremental cost-effectiveness ratio of €32,859 per quality adjusted life year gained. From the organizational perspective, the development of clear and comprehensive clinical pathways is crucial.Conclusions.The assessment supports the use of belimumab into the SLE treatment paradigm in Italy.
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- 2014
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19. Building successful collaborations between Public Health and Primary Health Care
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Maria Lucia, Specchia, Antonio Giulio, de Belvis, Silvio, Capizzi, Maria Assunta, Veneziano, Flavia, Kheiraoui, Luca, Morelli, Anna Maria, Ferriero, Chiara, Cadeddu, and Walter, Ricciardi
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Infection Control ,Primary Health Care ,Delivery of Health Care, Integrated ,Developed Countries ,Chronic Disease ,Outcome Assessment, Health Care ,Humans ,Public Health ,Cooperative Behavior ,Global Health ,Developing Countries - Abstract
Public Health (PH) and Primary Health Care (PHC) need to be better integrated, at different levels of the healthcare system, in order to improve health and social outcomes. The aim of this study was to review international models and approaches supporting the integration of PH and PHC and to classify these according to their main focus. A literature search was performed using the main scientific databases, to identify national and international journal publications regarding models to support integration between PH and PHC. The final set of the documents provided a broad coverage of the topic. Four models of integration were identified: general integration, chronic disease prevention, targeted prevention or care delivery and infection control. Models differed in their levels of implementation, stages of development and focus. This review, by classifying the main characteristics and results of the experiences retrieved, indicates a relatively scarce use of integration models in the global health care landscape, with the exception of Canada. In fact, Canada has been a leader in developing models of integrated health systems that combine tailored approaches to influence personal health behaviour and community-oriented approaches to influence the health of the population. The review also revealed a general lack of experience in evaluating the sustainability of integration between PH and PHC, not only in terms of cost-effectiveness, but also in terms of better health and work conditions and self-perceived quality of care in the population. Collaboration between PH and PHC seems to be an important strategy for achieving principles of equity and access in health care and for ensuring a more equal distribution of health care services.
- Published
- 2013
20. Pharmaceutical policies: the effects of reference pricing, cost sharing and risk sharing on public expenditure. A literature review
- Author
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Chiara Cadeddu, Silvio Capizzi, Anna Maria Ferriero, Agostino Mancuso, E Lovato, Walter Ricciardi, Maria Lucia Specchia, and Maria Assunta Veneziano
- Subjects
Public economics ,Public Health, Environmental and Occupational Health ,Risk sharing ,Cost sharing ,Public expenditure ,Business ,Public Expenditure ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,Pharmaceutical Policies ,Reference pricing - Published
- 2013
21. Economic burden of community-acquired pneumonia and invasive pneumococcal diseases in subjects aged ≥50 years: the Italian situation
- Author
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Antonella Sferrazza, Maria Lucia Specchia, Maria Assunta Veneziano, C de Waure, G La Torre, Flavia Kheiraoui, Walter Ricciardi, and Silvio Capizzi
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medicine.medical_specialty ,Pediatrics ,Pneumococcal disease ,Inpatient care ,business.industry ,Public Health, Environmental and Occupational Health ,medicine.disease ,medicine.disease_cause ,National health service ,Pneumonia ,Community-acquired pneumonia ,Health care ,Streptococcus pneumoniae ,Emergency medicine ,medicine ,business ,Medical costs - Abstract
Background Streptococcus pneumoniae (Spn) is a common cause of Community-Acquired Pneumonia (CAP) and Invasive Pneunmococcal Diseases (IPD) and an important cause of health care costs. The purpose of this cost-of-illness analysis (COI) is to estimate the economic burden of diseases caused by Spn among people ≥50 years old in Italy. Methods This analysis was performed from the Italian National Health Service perspective. Only direct medical costs related to outpatient and inpatient care were …
- Published
- 2013
22. Peer pressure and public reporting within healthcare setting: improving accountability and health care quality in hospitals
- Author
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Maria Lucia, Specchia, Maria Assunta, Veneziano, Chiara, Cadeddu, Anna Maria, Ferriero, Silvio, Capizzi, and Walter, Ricciardi
- Subjects
Social Responsibility ,Quality Assurance, Health Care ,Humans ,Hospitals ,Peer Group ,Information Systems - Abstract
In the last few years, the need of public reporting of health outcomes has acquired a great importance. The public release of performance results could be a tool for improving health care quality and many attempts have been made in order to introduce public reporting programs within the health care context at different levels. It would be necessary to promote the introduction of a standardized set of outcome and performance measures in order to improve quality of health care services and to make health care providers aware of the importance of transparency and accountability.
- Published
- 2013
23. Are age and gender associated to tobacco use and knowledge among general practitioners? Results of a survey in Italy
- Author
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Brigid, Unim, Giuseppe, Del Prete, Maria Rosaria, Gualano, Silvio, Capizzi, Walter, Ricciardi, Antonio, Boccia, and Giuseppe, La Torre
- Subjects
Adult ,Male ,Health Knowledge, Attitudes, Practice ,general practitioner (GP) ,Data Collection ,lcsh:Public aspects of medicine ,Age Factors ,lcsh:RA1-1270 ,Middle Aged ,tobacco ,smoking ,Tobacco Use ,Logistic Models ,Sex Factors ,cessation ,counseling ,Italy ,Socioeconomic Factors ,General Practitioners ,Surveys and Questionnaires ,Humans ,Female ,Smoking Cessation ,Settore MED/42 - IGIENE GENERALE E APPLICATA - Abstract
OBJECTIVES: The aim of this study was to assess knowledge and opinions of Italian general practitioners about the effectiveness of smoking cessation interventions and physicians' attitudes in addressing tobacco-related issues. METHODS: The survey was carried out through a questionnaire administered to general practitioners (GPs) attending a medical refresher course. 133 Italian GPs participated in the study with a mean age of 51.4 years (SD = 6.2). RESULTS: The GPs had good knowledge about the predictors of smoking onset, pharmacotherapies for tobacco cessation and the clinical guidelines recommendations. Wrong answers were encountered for the prevalence of smokers in Italy, the Fagerstrom Test for nicotine dependence and minimal advice. Females were more subjected to higher knowledge about tobacco, and at lower risk to be a smoker/ex smoker. Furthermore, physicians > 50 years old living in northern Italy had higher knowledge score. CONCLUSIONS: Physician education on tobacco counseling is associated to increased comfort and practice in advising patients who smoke. Tobacco cessation training might increase the success rate of helping patients to quit smoking.
- Published
- 2013
24. Economic issues related to tobacco smoking
- Author
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Maria Lucia Specchia, Giuseppe La Torre, Guido Citoni, Silvio Capizzi, and Alice Mannocci
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supply ,smoking-related illnesses ,business.industry ,demand ,Economic issues ,Tobacco smoking ,humanities ,smoking ,Environmental health ,Production (economics) ,Medicine ,trade ,business ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,health care economics and organizations ,Tobacco product - Abstract
The aim of this chapter is to give an overview on the economic aspects related to tobacco smoking, including production and supply of tobacco products.
- Published
- 2013
25. Assessing Medical Devices: Threats And Opportunities In The Evaluation Of The Value Of New Technologies In Different Fields
- Author
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Flavia, Kheiraoui, Chiara De Waure, Maria Lucia Specchia, Stefano, Capri, Silvio, Capizzi, Chiara, Cadeddu, Maria Assunta Veneziano, Francesco Di Nardo, Nicola, Nicolotti, Gualano, MARIA ROSARIA, Daniela, Gliubizzi, Agostino, Mancuso, Giuseppe, Avallone, Maria Luisa Di Pietro, Giuseppe La Torre, and Walter, Ricciardi
- Published
- 2013
26. Can Clinical Governance tools improve the appropriateness in hospital stay?
- Author
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Gualtiero Ricciardi, Andrea Poscia, Silvio Capizzi, Maria Lucia Specchia, Antonio Giulio de Belvis, Gianfranco Damiani, Paolo Parente, Andrea Cambieri, S Bucci, Marco Colotto, and Massimo Volpe
- Subjects
Clinical governance ,clinical governance ,medicine.medical_specialty ,business.industry ,Emergency medicine ,Public Health, Environmental and Occupational Health ,medicine ,Medical emergency ,business ,medicine.disease ,appropriateness ,Hospital stay ,Settore MED/42 - IGIENE GENERALE E APPLICATA - Published
- 2013
27. The 13-valent pneumococcal conjugated vaccine introduction in subjects aged> 50 years: the result of a Health Technology Assessment
- Author
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Pietro Refolo, Anna Maria Ferriero, M.L. Di Pietro, Silvio Capizzi, Flavia Kheiraoui, C de Waure, G Furneri, Walter Ricciardi, Nicola Nicolotti, Antonella Sferrazza, Gualano, G La Torre, F Di Nardo, Maria Assunta Veneziano, R Saulle, Gliubizzi, Maria Lucia Specchia, Chiara Cadeddu, and Lorenzo G. Mantovani
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medicine.medical_specialty ,Pediatrics ,business.industry ,Public Health, Environmental and Occupational Health ,Health technology ,Context (language use) ,medicine.disease ,medicine.disease_cause ,Vaccine introduction ,Clinical trial ,Pneumonia ,Pneumococcal vaccine ,Epidemiology ,Streptococcus pneumoniae ,medicine ,health technology assessment ,business ,Settore MED/42 - IGIENE GENERALE E APPLICATA - Abstract
Background Streptococcus pneumoniae (Spn) is a common cause of Community-Acquired Pneumonia (CAP) and Invasive Pneunmococcal Diseases (IPD). Risk for infection increases in particular in elderly. The aim of the study was to evaluate the introduction of 13-valent conjugate pneumococcal vaccine (PCV13) among patients ≥50 years. Methods The epidemiological context was studied thought literature review and national databases consultation. PCV13 efficacy was assessed analysing results from clinical trial. …
- Published
- 2013
28. Project Financing in healthcare: the state of the art in Europe
- Author
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Chiara Cadeddu, G Avallone, Maria Lucia Specchia, Silvio Capizzi, E Lovato, Gualtiero Ricciardi, Agostino Mancuso, Anna Maria Ferriero, and Maria Assunta Veneziano
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Project Financing ,Harm reduction ,business.industry ,media_common.quotation_subject ,Healthcare ,Public Health, Environmental and Occupational Health ,Public administration ,Europe ,State (polity) ,Health care ,Medicine ,business ,Inclusion (education) ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,media_common - Abstract
two major Roma NGOs in Romania with regard to drug use among Roma. The main objective of this initiative was to prioritize the topic on the policy agenda and ensure proper funding for harm reduction activities. Results (effects/changes) Up to now, NAR and the two Roma NGOs have become open to the issue of drug use among Roma. Moreover, the Roma NGOs took the lead in changing the National Roma Strategy and, besides other topics, militated for the inclusion of drug use and harm reduction in the priorities of the Strategy. Lessons
- Published
- 2013
29. Health technology assessment of fostimon, a highly purified human-derived urofollitropin for the treatment of infertility
- Author
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Chiara, Cadeddu, Maria Lucia Specchia, Chiara De Waure, Francesco Di Nardo, Silvio, Capizzi, Stefano, Capri, Gualano, MARIA ROSARIA, Nicola, Nicolotti, Flavia, Kheiraoui, Antonella, Sferrazza, Agostino, Mancuso, Giuseppe, Avallone, Giuseppe La Torre, and Walter, Ricciardi
- Published
- 2013
30. A new drug responding an unmet need: belimumab in the treatment of systemic lupus erythematosus
- Author
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Chiara De Waure, Maria Lucia Specchia, Andrea, Doria, Giuseppe, Turchetti, Silvio, Capizzi, Luca, Iaccarino, Francesca, Pierotti, Flavia, Kheiraoui, Chiara, Cadeddu, Maria Assunta Veneziano, Ilaria, Palla, Francesco Di Nardo, Daniela, Gliubizzi, Antonella, Sferrazza, Nicola, Nicolotti, Gualano, MARIA ROSARIA, Giuseppe La Torre, Maria Luisa Di Pietro, and Walter, Ricciardi
- Published
- 2013
31. Health technology assessment evaluation of the 13-valent pneumococcal conjugate vaccine in the adult and elderly population
- Author
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Maria Lucia Specchia, Chiara De Waure, Flavia, Kheiraoui, Lorenzo, Mantovani, Maria Luisa Di Pietro, Chiara, Cadeddu, Francesco Di Nardo, Anna Maria Ferriero, Silvio, Capizzi, Gualano, MARIA ROSARIA, Nicola, Nicolotti, Antonella, Sferrazza, Maria Assunta Veneziano, Rosella, Saulle, Daniela, Gliubizzi, Giuseppe La Torre, and Walter, Ricciardi
- Published
- 2013
32. Economic burden of medical error: the Italian situation. A scientific literature review
- Author
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Chiara Cadeddu, G Avallone, Silvio Capizzi, Maria Lucia Specchia, Agostino Mancuso, Maria Assunta Veneziano, Anna Maria Ferriero, Gualtiero Ricciardi, and E Lovato
- Subjects
Pediatrics ,medicine.medical_specialty ,Medical education ,business.industry ,Public Health, Environmental and Occupational Health ,medicine ,Medical Error ,Scientific literature ,business ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,Economic Burden - Published
- 2013
33. [Pay for performance in primary care]
- Author
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Maria Lucia, Specchia, Maria Assunta, Veneziano, Silvio, Capizzi, and Walter, Ricciardi
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Primary Health Care ,Humans ,Reimbursement, Incentive ,Quality of Health Care - Abstract
Pay for Performance is a tool that links payment of healthcare professionals to the quality of health outcomes and processes. In this article the authors discuss the results of a literature review on the subject, highlighting the importance of introducing a Pay for Performance system in primary care, and the advantages and critical issues associated with the system. The experience of the British National Health Service and possible uses of the described payment system in Italy are also briefly discussed.
- Published
- 2012
34. Epidemiologia della degenerazione maculare senile (AMD)
- Author
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Nicola, Nicolotti, Giuseppe La Torre, Gualano, MARIA ROSARIA, Silvio, Capizzi, and Walter, Ricciardi
- Published
- 2009
35. Tobacco use prevalence, knowledge and attitudes among hospital healthcare professionals: a multicenter study in Italy
- Author
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Maria Giovanna Ficarra, Gualano, MARIA ROSARIA, Silvio, Capizzi, Siliquini, Roberta, Giorgio, Liguori, Lamberto, Manzoli, Lamberto, Briziarelli, Antonino, Parlato, Pasquale, Cuccurullo, Roberto, Bucci, Simone Chiadò Piat, Giuseppe, Masanotti, Walter, Ricciardi, and Giuseppe La Torre
- Published
- 2009
36. Il trattamento del carcinoma metastatico della mammella con lapatinib. La risposta dell’Health Technology Assessment
- Author
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Maria Lucia Specchia, Giuseppe La Torre, Carlo, Barone, Chiara de Waure, Silvio, Capizzi, Nicola, Nicolotti, Gualano, MARIA ROSARIA, Alice, Mannocci, Emma De Feo, and Walter, Ricciardi
- Published
- 2009
37. OPTIGOV - A new methodology for evaluating Clinical Governance implementation by health providers
- Author
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Alessandro Campana, Giuseppe La Torre, Roberta Siliquini, Walter Ricciardi, Pierangela Nardella, Luca Valerio, Maria Lucia Specchia, and Silvio Capizzi
- Subjects
Clinical governance ,medicine.medical_specialty ,Process management ,Quality Assurance, Health Care ,business.industry ,lcsh:Public aspects of medicine ,Corporate governance ,Public health ,Nursing research ,Health Policy ,lcsh:RA1-1270 ,Health informatics ,Project team ,Health administration ,Hospital Administration ,Nursing ,Surveys and Questionnaires ,Correspondence ,Health care ,medicine ,Diffusion of Innovation ,business - Abstract
Background The aim of Clinical Governance (CG) is to the pursuit of quality in health care through the integration of all the activities impacting on the patient into a single strategy. OPTIGOV (Optimizing Health Care Governance) is a methodology for the assessment of the level of implementation of CG within healthcare organizations. The aim of this paper is to explain the process underlying the development of OPTIGOV, and describe its characteristics and steps. Methods OPTIGOV was developed in 2006 by the Institute of Hygiene of the Catholic University of the Sacred Heart and Eurogroup Consulting Alliance. The main steps of the process were: choice of areas for analysis and questionnaire development, based on a review of scientific literature; assignment of scores and weights to individual questions and areas; implementation of a software interfaceable with Microsoft Office. Results OPTIGOV consists of: a) a hospital audit with a structured approach; b) development of an improvement operational plan. A questionnaire divided into 13 areas of analysis is used. For each area there is a form with a variable number of questions and "closed" answers. A score is assigned to each answer, area of analysis, healthcare department and unit. The single scores can be gathered for the organization as a whole. The software application allows for collation of data, calculation of scores and development of benchmarks to allow comparisons between healthcare organizations. Implementation consists of three stages: the preparation phase includes a kick off meeting, selection of interviewees and development of a survey plan. The registration phase includes hospital audits, reviewing of hospital documentation, data collection and score processing. Lastly, results are processed, inserted into a final report, and discussed in a meeting with the Hospital Board and in a final workshop. Conclusions The OPTIGOV methodology for the evaluation of CG implementation was developed with an evidence-based approach. The ongoing adoption of OPTIGOV in several projects will put to the test its potential to realistically represent the organization status, pinpoint criticalities and transferable best practices, provide a plan for improvement, and contribute to triggering changes and pursuit of quality in health care.
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