Search

Objetivou-se, com o presente relato, descrever um caso de colite hiperplásica associada ao parasitismo por Strongyloides sp. em um gato macho de dois anos de idade, atendido na emergência apresentando tenesmo e prolapso retal. Foi realizada uma laparotomia exploratória em que foi possível observar nódulos transmurais no ceco e cólon, com diâmetro variando entre 2 e 4mm, de distribuição multifocal a coalescente, consistência firme e que, ao corte, continham sangue. Histologicamente, os nódulos eram áreas circulares compostas por projeções da mucosa intestinal para a submucosa, formadas por estruturas tubulares revestidas por uma camada de enterócitos volumosos monomórficos e raras células caliciformes. Larvas rabditoides, filarioides e adultos com morfologias compatíveis com nematoides do gênero Strongyloides foram observados no lume do epitélio hiperplásico, entre os túbulos e no limite dos nódulos, possivelmente constituindo a causa primária dessas alterações no animal.

This study aimed to investigate the effects of oral administration of Platonia insignis Mart. (“bacuri”) seed butter (BSB) on oxidative stress and diabetes mellitus-related parameters in streptozotocin-induced (STZ) diabetic rats. Diabetes mellitus was induced in female Wistar rats (180–250 g) by the intraperitoneal administration of STZ (45 mg/kg, b.w). BSB (25, 50, and 100 mg/kg) was administered to animals for four weeks. The effect on weight gain, food intake, blood glucose, glycated hemoglobin, hepatic transaminases, plasma and liver TBARS and MPO activity, erythrocyte SOD activity, non-protein sulfhydryl groups (SH-NP), and histopathology of the liver tissue was investigated. BSB at the dose of 100 mg/kg had a positive effect on the reduction in glycated hemoglobin percentage and increased albumin concentration, as well as decreased ALT and AST levels and increased SH-NP liver levels in treated animals compared to normal control rats. Moreover, BSB had no effects on weight gain, food intake, and fasting glucose. Thus, the BSB presented marked properties in improvement of hepatic antioxidant defenses, which demonstrates BSB as a potential hepatoprotective agent in metabolic disorders.

Abstract A high frequency of feline leishmaniasis has been reported in several countries. However, much information about disease progression in cats still needs to be clarified. This study aimed to verify the occurrence of clinicopathological changes in cats infected with Leishmania infantum. A total of 60 cats were divided into three groups of 20 animals each: control, suspects, and infected. All 60 cats underwent blood count and biochemical analyses. Serum samples from 20 animals with leishmaniasis were also used to diagnose feline immunodeficiency virus and feline leukemia virus. A total of five of the infected animals underwent necropsy for a histopathological study. The main clinical findings in cats with leishmaniasis were lymphadenomegaly (65%), alopecia (55%), ulcerative skin lesions and weight loss (40%), skin nodules (25%), a significant reduction in red blood cells (p=0.0005) and hematocrit (p=0.0007), hyperplasia in spleen 4/5(80%), presence of Leishmania in the spleen 2/5(40%), hepatitis 3/5(60%), liver degeneration 4/5(80%) and inflammatory nephropathy 3/5(60%). It was concluded that cats with leishmaniasis presented significant clinical, hematological, and histopathological alterations compatible with L. infantum infection. The observation of lymphadenomegaly, weight loss, skin lesions and low concentration of red blood cells, contributes significantly to the diagnosis and analysis of progression of feline leishmaniasis.

Abstract Purpose: To assess the efficacy of allogeneic mesenchymal stem cells and xenogenic platelet rich plasma in the treatment of bone failure of osteoporotic rabbits secondary to estrogenic deprivation and iatrogenic hypercortisolism. Methods: Eight female rabbits underwent ovarian resection and corticoid therapy to induce clinical status of osteoporosis. Four failures were produced in the tibiae, with each failure being treated with hemostatic sponge, allogenic mesenchymal stem cells, xenogenic platelet-rich plasma and the association between both. The animals were divided into two groups, evaluated radiographically and histopathologically at 30 and 60 days post treatment. Results: A radiographically confirmed consolidation of bone failures treated with allogeneic mesenchymal stem cells, associated with the histopathological image of mature and immature bone tissue, without evidence of osteopenia, was compared with the other groups, in which radiolucent failures with osteopenia and fibrosis were still present, denoting the satisfactory effect of the first treatment in detriment to the others. Conclusion: The treatment of bone failures of rabbits with secondary osteoporosis with allogeneic mesenchymal stem cells induced greater bone consolidation with mature and immature bone tissue production (p

As neoplasias testiculares em cães são predominantes em animais com criptorquidismo. Sendo as mais comuns sertolioma e o seminoma. Este último se desenvolve nos túbulos seminíferos, sendo a segunda neoplasia testicular mais encontrada em cães. O diagnóstico é confirmado apenas com a histopatologia dos testículos coletado durante a cirurgia, a qual é a terapia de eleição para retirada do tumor. A remoção dos testículos é a terapia preferencial, pois estudos sobre quimioterápicos para esta neoplasia ainda são escassos. Revisa-se neste estudo o seminoma, através de um relato de caso como também os protocolos terapêuticos escolhidos.

Testicular neoplasia are prevalent in dogs with cryptorchidism. The most common are sertolioma and seminoma. The seminoma develops in the seminiferous tubules and this is second most frequent testicular neoplasia in dogs. The diagnosis is confirmed with histopathology of the testicle collected during surgery for tumor removal. The removal of the testicle is the therapy preferred once studies on chemotherapy for this cancer are still scarce. This review about seminoma occurs through a case report as well as therapeutic protocols chosen