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329 results on '"Silvestri, Rosalia"'

1. Phenotyping sleep disturbances in ADHD and identifying harmonised outcome measures: A personalised precision medicine approach to disruptive behaviours

Author

Ipsiroglu, Osman S., Klösch, Gerhard, Stein, Mark, Blunden, Sarah, Brand, Serge, Clemens, Stefan, Cortese, Samuele, Dück, Alexander, Dye, Thomas, Gringras, Paul, Kühle, Hans-Jürgen, Lawrence, Kate, Lecendreux, Michel, Miano, Silvia, Mollin, Julian, Nobili, Lino, Owens, Judy, Kaur Pandher, Parveer, Sadeghi-Bahmani, Dena, Schlarb, Angelika Anita, Schneider, Barbara, Silvestri, Rosalia, Smith, Susan, Spruyt, Karen, and Weiss, Margaret Danielle

Published
2024
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9. Iron Deficiency and Sleep/Wake Behaviors: A Scoping Review of Clinical Practice Guidelines—How to Overcome the Current Conundrum?

Author

McWilliams, Scout, Hill, Olivia, Ipsiroglu, Osman S., Clemens, Stefan, Weber, Alexander Mark, Chen, Michael, Connor, James, Felt, Barbara T., Manconi, Mauro, Mattman, Andre, Silvestri, Rosalia, Simakajornboon, Narong, Smith, Susan M., and Stockler, Sylvia

Abstract

Current evidence suggests that iron deficiency (ID) plays a key role in the pathogenesis of conditions presenting with restlessness such as attention deficit hyperactivity disorder (ADHD) and restless legs syndrome (RLS). In clinical practice, ID and iron supplementation are not routinely considered in the diagnostic work-up and/or as a treatment option in such conditions. Therefore, we conducted a scoping literature review of ID guidelines. Of the 58 guidelines included, only 9 included RLS, and 3 included ADHD. Ferritin was the most frequently cited biomarker, though cutoff values varied between guidelines and depending on additional factors such as age, sex, and comorbidities. Recommendations surrounding measurable iron biomarkers and cutoff values varied between guidelines; moreover, despite capturing the role of inflammation as a concept, most guidelines often did not include recommendations for how to assess this. This lack of harmonization on the interpretation of iron and inflammation biomarkers raises questions about the applicability of current guidelines in clinical practice. Further, the majority of ID guidelines in this review did not include the ID-associated disorders, ADHD and RLS. As ID can be associated with altered movement patterns, a novel consensus is needed for investigating and interpreting iron status in the context of different clinical phenotypes. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Gender medicine and sleep disorders: from basic science to clinical research.

Author

Perger, Elisa, Silvestri, Rosalia, Bonanni, Enrica, Di Perri, Maria Caterina, Fernandes, Mariana, Provini, Federica, Zoccoli, Giovanna, and Lombardi, Carolina

Subjects
SLEEP disorders, GENDER medicine, MEDICAL research, GENDER, GENDER differences (Psychology)
Abstract

Several pivotal differences in sleep and sleep disorders are recognized between women and men. This is not only due to changes in hormonal balance during women's reproductive life, such as in pregnancy and menopause. Women are more likely to report insomnia and non-specific symptoms of apneas, such as fatigue or mood disturbance, compared to men. Thus, it is important for clinicians and researchers to take sex and gender differences into account when addressing sleep disorders in order to acknowledge the biology unique to women. We present a narrative review that delves into the primary sleep disorders, starting from basic science, to explore the impact of gender differences on sleep and the current status of research on women's sleep health. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Is iron depletion the only cause of motor restlessness in restless sleep presenting in autism spectrum disorder?Commentary on Voci A, Mazzone L, De Stefano D, Valeriani M, Bruni O, Moavero R. Restless sleep disorder in a sample of children and adolescents with autism spectrum disorder: preliminary results from a case series. J Clin Sleep Med . 2024;20(3):427–432. doi:10.5664/jcsm.10902

Author

Silvestri, Rosalia, primary and Di Perri, Maria Caterina, additional

Published
2024
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16. Sleep, vigilance & disruptive behaviours

Author

Ipsiroglu, Osman S., Kloesch, Gerhard, Silvestri, Rosalia Cesarea, McCabe, Susan Mary, Dorffner, Georg, Wetter, Thomas Christian, Wiggs, Luci, Ipsiroglu, Osman S., Kloesch, Gerhard, Silvestri, Rosalia Cesarea, McCabe, Susan Mary, Dorffner, Georg, Wetter, Thomas Christian, and Wiggs, Luci

Published
2023

17. Editorial: Sleep, vigilance & disruptive behaviors

Author

Ipsiroglu, Osman S., Klösch, Gerhard, Silvestri, Rosalia C., McCabe, Susan M., Dorffner, Georg, Wetter, Thomas C., Wiggs, Luci, Ipsiroglu, Osman S., Klösch, Gerhard, Silvestri, Rosalia C., McCabe, Susan M., Dorffner, Georg, Wetter, Thomas C., and Wiggs, Luci

Abstract

The Frontiers in Psychiatry Research Theme of Sleep, vigilance, and disruptive behaviors has two aims: first, to promote the understanding of the connections between vigilance and disruptive daytime behavior in the context of sleep deprivation and, second, to explore how naturalistic observations and pattern recognition can play a role in furthering our understanding of these connections. . . .

Published
2023

22. Additional file 1 of Hyperactivity in patients with narcolepsy and idiopathic hypersomnia: an exploratory study

Author

Dodson, Caroline, Spruyt, Karen, Considine, Ciaran, Thompson, Emily, Ipsiroglu, Osman S., Bagai, Kanika, Silvestri, Rosalia, Couvadelli, Barbara, and Walters, Arthur S.

Abstract

Additional file 1: Supplementary Table 1. Descriptive Means±standard deviations and proportions (%) above clinical cut-off score, of the ESS score, ISI score, PhQ-4 score, VAS sleepiness, and Digit Vigilance Test per patients on/off medication.

Published
2023
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23. Understanding patient characteristics and medication prescriptions in children with mental health and neurodevelopmental disorders referred to a sleep clinic—A quality improvement/quality assurance analysis

Author

Ipsiroglu, Osman S., primary, Bhathella, Juhi, additional, Boldut, Renee Paula, additional, Elbe, Dean, additional, Hill, Olivia, additional, Keys, Elizabeth, additional, McWilliams, Scout, additional, Silvestri, Rosalia, additional, and Wensley, David F., additional

Published
2022
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33. Sleep-related movement disorders in children and adolescents

Author

Silvestri, Rosalia and Nevsimalova, Sona

Subjects
body rocking/rolling, iron, periodic leg movements, body rocking/rolling, iron, pediatric sleep disorders, periodic leg movements, restless sleep, restless sleep, pediatric sleep disorders
Published
2021

34. Association of rs3027178 polymorphism in the circadian clock gene PER1 with susceptibility to Alzheimer's disease and longevity in an Italian population

Author

Bacalini Maria Giulia, Palombo, Flavia, Garagnani, Paolo, Giuliani, Cristina, Fiorini, Claudio, Caporali, Leonardo, Maserati Michelangelo Stanzani, Capellari, Sabina, Romagnoli, Martina, De Fanti Sara, Benussi, Luisa, Binetti, Giuliano, Ghidoni, Roberta, Galimberti, Daniela, Scarpini, Elio, Arcaro, Marina, Bonanni, Enrica, Siciliano, Gabriele, Maestri, Michelangelo, Guarnieri, Biancamaria, Cucchiara, Federico, Schirru, Alessandro, Lo Gerfo Annalisa, Lombardi, Gemma, Arnaldi, Dario, Mattioli, Pietro, Nobili, Flavio, Cerroni, Gianluigi, Bartoli, Antonella, Manni, Raffaele, Elena, Sinforian, Terzaghi, Michele, Arena, Maria Grazia, Silvestri, Rosalia, Di Perri Maria Caterina, Franzoni, Ferdinando, Tognoni, Gloria, Mancuso, Michelangelo, Sorbi, Sandro, Bonuccelli, Ubaldo, Faraguna, Ugo, Martucci, Morena, Monti, Daniela, Carelli, Valerio, Franceschi, Claudio, La Morgia Chiara, Santoro, Aurelia, Bacalini, Maria Giulia, Palombo, Flavia, Garagnani, Paolo, Giuliani, Cristina, Fiorini, Claudio, Caporali, Leonardo, Stanzani Maserati, Michelangelo, Capellari, Sabina, Romagnoli, Martina, De Fanti, Sara, Benussi, Luisa, Binetti, Giuliano, Ghidoni, Roberta, Galimberti, Daniela, Scarpini, Elio, Arcaro, Marina, Bonanni, Enrica, Siciliano, Gabriele, Maestri, Michelangelo, Guarnieri, Biancamaria, Martucci, Morena, Monti, Daniela, Carelli, Valerio, Franceschi, Claudio, La Morgia, Chiara, and Santoro, Aurelia

Subjects
Aged, 80 and over, Aging, CLOCK gene, Longevity, Period Circadian Proteins, Aging · Alzheimer’s disease · Centenarians · CLOCK genes · Polymorphism · Circadian rhythms, Alzheimer’s disease, CLOCK genes, Centenarians, Circadian rhythms, Polymorphism, Circadian Rhythm, Humans, Italy, Alzheimer Disease, Circadian Clocks, Settore BIO/13 - Biologia Applicata, 80 and over, Centenarian, Geriatrics and Gerontology, Aged
Abstract

Many physiological processes in the human body follow a 24-h circadian rhythm controlled by the circadian clock system. Light, sensed by retina, is the predominant “zeitgeber” able to synchronize the circadian rhythms to the light-dark cycles. Circadian rhythm dysfunction and sleep disorders have been associated with aging and neurodegenerative diseases including mild cognitive impairment (MCI) and Alzheimer’s disease (AD). In the present study, we aimed at investigating the genetic variability of clock genes in AD patients compared to healthy controls from Italy. We also included a group of Italian centenarians, considered as super-controls in association studies given their extreme phenotype of successful aging. We analyzed the exon sequences of eighty-four genes related to circadian rhythms, and the most significant variants identified in this first discovery phase were further assessed in a larger independent cohort of AD patients by matrix assisted laser desorption/ionization-time of flight mass spectrometry. The results identified a significant association between the rs3027178 polymorphism in the PER1 circadian gene with AD, the G allele being protective for AD. Interestingly, rs3027178 showed similar genotypic frequencies among AD patients and centenarians. These results collectively underline the relevance of circadian dysfunction in the predisposition to AD and contribute to the discussion on the role of the relationship between the genetics of age-related diseases and of longevity.

Published
2021

40. Multicenter Study on Sleep and Circadian Alterations as Objective Markers of Mild Cognitive Impairment and Alzheimer’s Disease Reveals Sex Differences

Author

Guarnieri, Biancamaria, primary, Maestri, Michelangelo, additional, Cucchiara, Federico, additional, Lo Gerfo, Annalisa, additional, Schirru, Alessandro, additional, Arnaldi, Dario, additional, Mattioli, Pietro, additional, Nobili, Flavio, additional, Lombardi, Gemma, additional, Cerroni, Gianluigi, additional, Bartoli, Antonella, additional, Manni, Raffaele, additional, Sinforiani, Elena, additional, Terzaghi, Michele, additional, Arena, Maria Grazia, additional, Silvestri, Rosalia, additional, La Morgia, Chiara, additional, Di Perri, Maria Caterina, additional, Franzoni, Ferdinando, additional, Tognoni, Gloria, additional, Mancuso, Michelangelo, additional, Sorbi, Sandro, additional, Bonuccelli, Ubaldo, additional, Siciliano, Gabriele, additional, Faraguna, Ugo, additional, and Bonanni, Enrica, additional

Published
2020
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47. Video Recordings of Naturalistic Observations: Pattern Recog­nition of Disruptive Behaviours in People with Mental Health or Neurodevelopmental Conditions

Author

Ipsiroglu, Osman S., Gerhard, Kloesch, Nadia, Beyzaei, Sue, Mccabe, Mai, Berger, Kühle, Hans J., Bernhard, Kohn, Joseph, Puyat, Machiel Van der Loos, H. F., Heinrich, Garn, Allen, Richard P., Mark, Blumberg, Oliviero, Bruni, David, Champion, Giovanni, Cioni, Felt, Barbara T., Andrea, Guzetta, Hill, Catherine M., Reinhold, Kerbl, Sebastian, Kerzel, Suresh, Kotagal, Teresa, Paiva, Federica, Provini, Owens, Judith A., Denise, Sharon, Silvestri, Rosalia, Karen, Spruyt, Arthur, Teng, and Arthur, Walters

Subjects
Video Recordings, Naturalistic Observations, Pattern Recognition, Disruptive Behaviours, Mental Health, Neurodevelopmental Disorders, Intellectual Disability, Mental Health, Disruptive Behaviours, Neurodevelopmental Disorders, Naturalistic Observations, Intellectual Disability, Pattern Recognition, Video Recordings
Published
2017

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