729 results on '"Silvestri, Romano"'
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2. Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators
3. Chemo- and enantio-selective reversed-phase HPLC analysis of rosuvastatin using a cellulose-based chiral stationary phase in gradient elution mode
4. RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo
5. Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment
6. Toll-Like Receptor 4-Dependent Platelet-Related Thrombosis in SARS-CoV-2 Infection
7. Targeting CBP and p300: Emerging Anticancer Agents.
8. Modulating undruggable targets to overcome cancer therapy resistance
9. Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia
10. New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains
11. Selenotriapine – An isostere of the most studied thiosemicarbazone with pronounced pro-apoptotic activity, low toxicity and ability to challenge phenotype reprogramming of 3-D mammary adenocarcinoma tumors
12. Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies
13. Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer
14. Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics
15. Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: Structure-activity relationships and mode of action studies
16. Metabolic Rewiring in Cancer: Small Molecule Inhibitors in Colorectal Cancer Therapy.
17. Quinoline‐based thiazolyl‐hydrazones target cancer cells through autophagy inhibition
18. Recent Advances in Drug Discovery for Triple-Negative Breast Cancer Treatment
19. 4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells
20. New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors
21. Biological evaluation of [4‐(4‐aminophenyl)‐1‐(4‐fluorophenyl)‐1H‐pyrrol‐3‐yl](3,4,5‐trimethoxyphenyl)methanone as potential antineoplastic agent in 2D and 3D breast cancer models
22. Novel N-(Heterocyclylphenyl)benzensulfonamide Sharing an Unreported Binding Site with T-Cell Factor 4 at the β-Catenin Armadillo Repeats Domain as an Anticancer Agent
23. Heterocyclic pharmacochemistry of new rhinovirus antiviral agents: A combined computational and experimental study
24. Mutational analysis of the essential lipopolysaccharide-transport protein LptH of Pseudomonas aeruginosa to uncover critical oligomerization sites
25. Quinoline‐based thiazolyl‐hydrazones target cancer cells through autophagy inhibition.
26. β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy
27. Rimonabant-Based Compounds Bearing Hydrophobic Amino Acid Derivatives as Cannabinoid Receptor Subtype 1 Ligands
28. Recent Advances in Drug Discovery for Triple-Negative Breast Cancer Treatment
29. VP1 crystal structure-guided exploration and optimization of 4,5-dimethoxybenzene-based inhibitors of rhinovirus 14 infection
30. Structure-activity relationship of dibenzylideneacetone analogs against the neglected disease pathogen, Trypanosoma brucei
31. A Novel Validated UHPLC Method for the Estimation of Rosuvastatin and Its Complete Impurity Profile in Tablet Formulations
32. New 1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides inhibit hepatitis C virus replication via suppression of cyclooxygenase-2
33. Structural Investigations on Novel Non-Nucleoside Inhibitors of Human Norovirus Polymerase
34. Multiplexed cellular profiling identifies an organoselenium compound as an inhibitor of CRM1 ‐mediated nuclear export
35. Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor
36. Emerging Direct Targeting β-Catenin Agents
37. New indolylarylsulfones as highly potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors
38. Exploring 4-substituted-2-thiazolylhydrazones from 2-, 3-, and 4-acetylpyridine as selective and reversible hMAO-B inhibitors
39. Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus
40. Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor
41. Anticancer Activity of (S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide (RS4690), a New Dishevelled 1 Inhibitor
42. Pharmacological folding chaperones act as allosteric ligands of Frizzled4
43. De novo computer-aided design of novel antiviral agents
44. Exploring CCRL2 chemerin binding using accelerated molecular dynamics
45. Anticancer Activity of (S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide (RS4690), a New Dishevelled 1 Inhibitor
46. 1-Aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamide: An effective scaffold for the design of either CB1 or CB2 receptor ligands
47. Single‐run chemo‐ and enantio‐selective high‐performance liquid chromatography separation of tramadol and its principal metabolite, O‐desmethyltramadol, using a chlorinated immobilized amylose‐based chiral stationary phase under multimodal elution conditions
48. RS6077 Induces Mitotic Arrest and Selectively Activates Cell Death in Human Cancer Cell Lines and in a Lymphoma Tumor In Vivo
49. Emerging Therapeutic Agents for Colorectal Cancer
50. Structural Investigations on Novel Non-Nucleoside Inhibitors of Human Norovirus Polymerase.
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