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2. Diabetes Technologies and Their Role in Diabetes Management

Author

Kollipara, Sobha, Silverstein, Janet H., and Marschilok, Katie

Abstract

The 1993 Diabetes Complications and Control Trial (DCCT) showed that controlling blood glucose prevents and delays the progression of long term complications of diabetes. New diabetes technologies can make control of diabetes possible and safer. This paper reviews these technologies used to monitor blood glucose, administer insulin and evaluate effectiveness of therapy. Self-monitoring of blood glucose has been a standard of care for several decades. Today, patients and practitioners can gain great benefit from data that can be provided by using Continuous Glucose Monitoring (CGM). Current physiologic insulin therapy regimens have improved blood glucose control capabilities. Insulin therapy devices; including pens and pumps are reviewed. Advantages of insulin pump therapy and features of the latest "smart" pumps are described. Children with diabetes, and their families, have many challenges as well as many opportunities to employ new technologies in diabetes management plans. The ability of school and care givers to support children can impact the overall success of any diabetes therapy regimen. (Contains 2 tables and 2 figures.)

Published
2009

3. Providing a Safe Environment for Students with Diabetes

Author

Silverstein, Janet H., Jackson, Crystal C., and Bobo, Nichole

Abstract

Current diabetes regimens require more effort than ever before. The level of diabetes control students are able to maintain is affected greatly by their ability to care for their diabetes during the school day. This article reviews use of School Health Plans and Diabetes Medical Management Plans in schools. Students with diabetes, their families, health care providers and school personnel all have responsibilities that should be outlined in these plans. School nurses coordinate school-based diabetes care, provide training to school staff members, advocate for students and monitor implementation of students' school plans. Normal growth and development, prevention of complications and full participation in academic and social opportunities should be possible for students with diabetes. A variety of resources that support students with diabetes are described and referenced.

Published
2009

5. Obesity in Youth with Type 1 Diabetes in Germany, Austria, and the United States

Author

Willi, Steven, Lipman, Terri, Calvano, Tammy, Kucheruk, Olena, Minnock, Pantea, Nguyen, Chau, Klingensmith, Georgeanna, Banion, Carolyn, Barker, Jennifer, Cain, Cindy, Chase, Peter, Hoops, Sandy, Kelsy, Megan, Maahs, David, Mowry, Cathy, Nadeau, Kristen, Raymond, Jennifer, Rewers, Marian, Rewers, Arleta, Slover, Robert, Steck, Andrea, Wadwa, Paul, Walravens, Philippe, Zeitler, Philip, Haro, Heidi, Manseau, Katherine, Weinstock, Ruth, Izquierdo, Roberto, Sheikh, Umair, Conboy, Patricia, Bulger, Jane, Bzdick, Suzan, Goland, Robin, Gandica, Rachelle, Weiner, Lindsay, Cook, Steve, Greenberg, Ellen, Kohm, Kevin, Pollack, Sarah, Lee, Joyce, Gregg, Brigid, Tan, Meng, Burgh, Kimberly, Eason, Ashley, Garg, Satish, Michels, Aaron, Myers, Lisa, DiMeglio, Linda, Hannon, Tamara, Orr, Donald, Cruz, Christy, Woerner, Stephanie, Wolfsdorf, Joseph, Quinn, Maryanne, Tawa, Olivia, Ahmann, Andrew, Castle, Jessica, Joarder, Farahnaz, Bogan, Chris, Cady, Nancy, Cox, Jennifer, Pitts, Amy, Fitch, Rebecca, White, Brad, Wollam, Bethany, Bode, Bruce, Lindmark, Katie, Hosey, RaShonda, Bethin, Kathleen, Quattrin, Teresa, Ecker, Michelle, Wood, Jamie, Chao, Lily, Cheung, Clement, Fisher, Lynda, Jeandron, Debra, Kaufman, Francine, Kim, Mimi, Miyazaki, Brian, Monzavi, Roshanak, Patel, Payal, Pitukcheewanont, Pisit, Sandstrom, Anna, Cohen, Marisa, Ichihara, Brian, Lipton, Megan, Cemeroglu, Ayse, Appiagyei-Dankah, Yaw, Daniel, Maala, Postellon, Daniel, Racine, Michael, Wood, Michael, Kleis, Lora, Hirsch, Irl, DeSantis, Anthony, Dugdale, D.C., Failor, R. Alan, Gilliam, Lisa, Greenbaum, Carla, Janci, Mary, Odegard, Peggy, Trence, Dace, Wisse, Brent, Batts, Emily, Dove, Angela, Hefty, Deborah, Khakpour, Dori, Klein, Jani, Kuhns, Kristen, McCulloch-Olson, Marli, Peterson, Christina, Ramey, Mary, Marie, Marissa St., Thomson, Pam, Webber, Christine, Liljenquist, David, Sulik, Mark, Vance, Carl, Coughenour, Tiffany, Brown, Chris, Halford, Jean, Prudent, Andrea, Rigby, Shanda, Robison, Brandon, Starkman, Harold, Berry, Tymara, Cerame, Barbara, Chin, Daisy, Ebner-Lyon, Laurie, Guevarra, Frances, Sabanosh, Kristen, Silverman, Lawrence, Wagner, Christine, Fox, Marie, Buckingham, Bruce, Shah, Avni, Caswell, Kimberly, Harris, Breanne, Bergenstal, Richard, Criego, Amy, Damberg, Greg, Matfin, Glenn, Powers, Margaret, Tridgell, David, Burt, Cassie, Olson, Beth, Thomas, LeeAnn, Mehta, Sanjeev, Katz, Michelle, Laffel, Lori, Hathway, Joanne, Phillips, Roxanne, Cengiz, Eda, Tamborlane, William, Cappiello, Darryll, Steffen, Amy, Zgorski, Melinda, Peters, Anne, Ruelas, Valerie, Benjamin, Robert, Adkins, Deanna, Cuffee, Juanita, Spruill, Amber, Aleppo-Kacmarek, Grazia, Derby, Teresa, Massaro, Elaine, Webb, Kimberly, Burt Solorzano, Christine, DeBoer, Mark, Madison, Helen, McGill, Janet, Buechler, Lori, Clifton, Mary Jane, Hurst, Stacy, Kissel, Sarah, Recklein, Carol, Tsalikian, Eva, Tansey, Michael, Cabbage, Joanne, Coffey, Julie, Salamati, Sarah, Clements, Mark, Raman, Sripriya, Turpin, Angela, Bedard, Jennifer, Cohoon, Cyndy, Elrod, Aliza, Fridlington, Amanda, Hester, Lois, Kruger, Davida, Schatz, Desmond, Clare-Salzler, Michael, Cusi, Kenneth, Digman, Colleen, Fudge, Becky, Haller, Mike, Meehan, Collette, Rohrs, Henry, Silverstein, Janet, Wagh, Sujata, Cintron, Miriam, Sheehan, Eleni, Thomas, Jamie, Daniels, Mark, Clark, Susan, Flannery, Timothy, Forghani, Nikta, Naidu, Ajanta, Reh, Christina, Scoggin, Peggy, Trinh, Lien, Ayala, Natalie, Quintana, Rebeca, Speer, Heather, Zipf, William, Seiple, Diane, Kittelsrud, Julie, Gupta, Ashutosh, Peterson, Vikki, Stoker, Ashley, Gottschalk, Michael, Hashiguchi, Marla, Smith, Katheryn, Rodriguez, Henry, Bobik, Craig, Henson, Danielle, Simmons, Jill, Potter, Amy, Black, Margo, Brendle, Faith, Gubitosi-Klug, Rose, Kaminski, Beth, Bergant, Susan, Campbell, Wendy, Tasi, Catherine, Copeland, Kenneth, Beck, Joni, Less, Joane, Schanuel, Jill, Tolbert, Jennifer, Adi, Saleh, Gerard-Gonzalez, Andrea, Gitelman, Stephen, Chettout, Nassim, Torok, Christine, Pihoker, Catherine, Yi-Frazier, Joyce, Kearns, Susan, Libman, Ingrid, Bills, Vicky, Diaz, Ana, Duke, Julie, Nathan, Brandon, Moran, Antoinette, Bellin, Melena, Beasley, Shannon, Kogler, Anne, Leschyshyn, Janice, Schmid, Kara, Street, Anne, Nelson, Bryce, Frost, Carrie, Reifeis, Erin, Haymond, Morey, Bacha, Fida, Caldas-Vasquez, Maria, Klinepeter, Sara, Redondo, Maria, Berlanga, Rosa, Falk, Teresa, Garnes, Elizabeth, Gonzalez, Janette, Martinez, Cecilia, Pontifes, Mariam, Yulatic, Ronald, Arnold, Kathleen, Evans, Traci, Sellers, Sharon, Raman, Vandana, Foster, Carol, Murray, Mary, Brown, Trina, Slater, Hillarie, Wheeler, Karen, Harlan, David, Lee, Mary, Lock, John-Paul, Hartigan, Celia, Hubacz, Lisa, Buse, John, Calikoglu, Ali, Largay, Joseph, Young, Laura, Brown, Helen, Duncan, Vinnie, Duclos, Michelle, Tricome, Julie, Brandenburg, Verdayne, Blehm, Julie, Hallanger-Johnson, Julie, Hanson, Dawn, Miller, Corliss, Weiss, Jennifer, Hoffman, Robert, Chaudhari, Monika, Repaske, David, Gilson, Elizabeth, Haines, Jesse, Rudolph, Justen, McClave, Charles, Biersdorf, Doris, Tello, Anthony, Amundson, Donna, Ward, Rhonda, Rickels, Michael, Dalton-Bakes, Cornelia, Markman, Eileen, Peleckis, Amy, Rosenfeld, Nora, Dolan, Lawrence, Corathers, Sarah, Kichler, Jessica, Baugh, Holly, Standiford, Debbie, Hassing, Jeanne, Jones, Jennifer, Willis, Stephen, Wysham, Carol, Davis, Lisa, Blackman, Scott, Abel, Kimber-Lee, Clark, Loretta, Jonas, Andrea, Kagan, Ellie, Sosenko, Jay, Blashke, Carlos, Matheson, Della, Edelen, Rachel, Repas, Thomas, Baldwin, Denise, Borgwardt, Trista, Conroy, Christina, DeGrote, Kelly, Marchiando, Rod, Wasson, Michelle, Fox, Larry, Mauras, Nelly, Damaso, Ligeia, Englert, Kim, Hamaty, Marwan, Kennedy, Laurence, Schweiger, Michelle, Konstantinopoulos, Pantelis, Mawhorter, Carolyn, Orasko, Amy, Rose, Denise, Deeb, Larry, Rohrbacher, Kim, Schroeder, Leroy, Roark, Amanda, Ali, Omar, Kramer, Joanna, Whitson-Jones, Donna, Gassner, Heidi, Kollipara, Sobha, Harwood, Katerina, Prasad, Vijaya, Brault, Judy, DuBose, Stephanie N., Hermann, Julia M., Tamborlane, William V., Beck, Roy W., Dost, Axel, DiMeglio, Linda A., Schwab, Karl Otfried, Holl, Reinhard W., Hofer, Sabine E., and Maahs, David M.

Published
2015
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18. Management of Type 2 Diabetes Mellitus in Children and Adolescents

Author

Springer, Shelley C., primary, Silverstein, Janet, additional, Copeland, Kenneth, additional, Moore, Kelly R., additional, Prazar, Greg E., additional, Raymer, Terry, additional, Shiffman, Richard N., additional, Thaker, Vidhu V., additional, Anderson, Meaghan, additional, Spann, Stephen J., additional, and Flinn, Susan K., additional

Published
2014
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26. Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children

Author

Stacpoole, Peter W., Kerr, Douglas S., Barnes, Carie, Bunch, S. Terri, Carney, Paul R., Fennell, Eileen M., Felitsyn, Natalia M., Gilmore, Robin L., Greer, Melvin, Henderson, George N., Hutson, Alan D., Neiberger, Richard E., O'Brien, Ralph G., Perkins, Leigh Ann, Quisling, Ronald G., Shroads, Albert L., Shuster, Jonathan J., Silverstein, Janet H., Theriaque, Douglas W., and Valenstein, Edward

Subjects
Children -- Health aspects, Lactic acidosis -- Care and treatment
Abstract

OBJECTIVE. Open-label studies indicate that oral dichloroacetate (DCA) may be effective in treating patients with congenital lactic acidosis. We tested this hypothesis by conducting the first double-blind, randomized, control trial of DCA in this disease. METHODS. Forty-three patients who ranged in age from 0.9 to 19 years were enrolled. All patients had persistent or intermittent hyperlactatemia, and most had severe psychomotor delay. Eleven patients had pyruvate dehydrogenase deficiency, 25 patients had 1 or more defects in enzymes of the respiratory chain, and 7 patients had a mutation in mitochondrial DNA. Patients were preconditioned on placebo for 6 months and then were randomly assigned to receive an additional 6 months of placebo or DCA, at a dose of 12.5 mg/kg every 12 hours. The primary outcome results were (1) a Global Assessment of Treatment Efficacy, which incorporated tests of neuromuscular and behavioral function and quality of life; (2) linear growth; (3) blood lactate concentration in the fasted state and after a carbohydrate meal; (4) frequency and severity of intercurrent illnesses and hospitalizations; and (5) safety, including tests of liver and peripheral nerve function. OUTCOME. There were no significant differences in Global Assessment of Treatment Efficacy scores, linear growth, or the frequency or severity of intercurrent illnesses. DCA significantly decreased the rise in blood lactate caused by carbohydrate feeding. Chronic DCA administration was associated with a fall in plasma clearance of the drug and with a rise in the urinary excretion of the tyrosine catabolite maleylacetone and the heme precursor [delta]-aminolevulinate. CONCLUSIONS. In this highly heterogeneous population of children with congenital lactic acidosis, oral DCA for 6 months was well tolerated and blunted the postprandial increase in circulating lactate. However, it did not improve neurologic or other measures of clinical outcome. Key Words dichloroacetate, congenital lactic acidosis, mitochondfia, clinical trial, pyruvate dehydrogenase, respiratory chain, peripheral neuropathy, Abbreviations PDC--pyruvate dehydrogenase complex mtDNA--mitochondrial DNA MELAS--mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes CSF--cerebrospinal fluid DCA--dichloroacetate TCA--tricarboxylic add GCRC--General Clinical Research Center DSMB--Data Safety Monitoring Board EEG--electroencephalogram GATE--Global Assessment of [...]

Published
2006

27. Screening for retinopathy in the pediatric patient with type 1 diabetes mellitus

Author

Lueder, Gregg T. and Silverstein, Janet

Subjects
Children -- Health aspects, Type 1 diabetes -- Diagnosis, Retinal diseases -- Diagnosis
Abstract

Diabetic retinopathy (DR) is the leading cause of blindness in young adults in the United States. Early identification and treatment of DR can decrease the risk of vision loss in affected patients. This clinical report reviews the risk factors for the development of DR and screening guidance for pediatric patients with type 1 diabetes mellitus. type 1 diabetes mellitus, diabetic retinopathy, ophthalmic screening. ABBREVIATIONS. DR, diabetic retinopathy; DCCT, Diabetes Control and Complications Trial., BACKGROUND Type 1 diabetes mellitus is one of the most common metabolic disorders in children, with a prevalence of approximately 2 per 1000 school-aged children in the United States. The [...]

Published
2005

28. Validation of the pediatric inventory for parents in mothers of children with Type 1 diabetes: an examination of parenting stress, anxiety, and childhood psychopathology

Author

Lewin, Adam B., Storch, Eric A., Silverstein, Janet H., Baumeister, Audrey L., Strawser, Melissa S., and Geffken, Gary R.

Subjects
Children
Abstract

The primary objective of this study was to provide psychometric validation of a measure of chronic disease-related parental stress in a sample of mothers of children with Type 1 diabetes. [...]

Published
2005

32. Type 2 diabetes mellitus among Florida children and adolescents, 1994 through 1998. (Research Articles)

Author

Macaluso, Christine J., Bauer, Ursula E., Deeb, Larry C., Malone, John I., Chaudhari, Monika, Silverstein, Janet, Eidson, Margaret, Goldberg, Ronald B., Gaughan-Bailey, Bonnie, Brooks, Robert G., and Rosenbloom, Arlan L.

Subjects
Chronically ill children -- Demographic aspects, Chronically ill children -- Statistics, Diabetics -- Demographic aspects, Diabetics -- Statistics, Type 2 diabetes -- Diagnosis, Type 2 diabetes -- Statistics
Abstract

Numerous reports have recently documented an increase in the frequency of Type 2 diabetes among children and adolescents. (1-8) The proportion of Type 2 diabetes among all children and adolescents […]

Published
2002

33. Technical Report: Congenital Adrenal Hyperplasia

Author

Frias, Jaime, Levine, Lenore S., Oberfield, Sharon E., Pang, Sonya, Silverstein, Janet, Schwartz, Robert P., Hansen, Inger L., Kaufman, Francine, Varma, Surendra Kumar, Oberfield, Sharon E., Silverstein, Janet, Levitsky, Lynn, Suriano, Mary Jean, Poulin, Laura, Cunniff, Christopher, Frias, Jaime L., Kaye, Celia, Moeschler, John B., Panny, Susan R., Trotter, Tracy L., de la Cruz, Felix, Hanson, James W., Lloyd-Puryear, Michele, Moore, Cynthia A., Williams, John, III, Hoyme, H. Eugene, and Hall, Lauri

Published
2000

38. Real-World Screening for Retinopathy in Youth With Type 1 Diabetes Using a Nonmydriatic Fundus Camera

Author

Zimmerman, Chelsea, primary, Bruggeman, Brittany, additional, LaPorte, Amanda, additional, Kaushal, Shalesh, additional, Stalvey, Michael, additional, Beauchamp, Giovanna, additional, Dayton, Kristin, additional, Hiers, Paul, additional, Filipp, Stephanie L., additional, Gurka, Matthew J., additional, Silverstein, Janet H., additional, and Jacobsen, Laura M., additional

Published
2020
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