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287 results on '"Silveri, Marisa M."'

7. Anterior cingulate metabolite levels, memory, and inhibitory control in abstinent men and women with alcohol use disorder.

Author

Oot, Emily N, Sawyer, Kayle S, Oscar-Berman, Marlene, Luhar, Riya B, Jensen, J E, and Silveri, Marisa M

Subjects
BRAIN abnormalities, PREVENTION of alcoholism, MEMORY, BIOCHEMISTRY, BRAIN, BIOMARKERS, RISK-taking behavior, ALCOHOLISM, LIMBIC system, NEUROBIOLOGY, NEUROPSYCHOLOGY, FUNCTIONAL status, PHENOMENOLOGICAL biology, CROSS-sectional method, PROTON magnetic resonance spectroscopy, MEN, WOMEN, COGNITION, TEMPERANCE, SEX distribution, RESEARCH funding, CEREBRAL cortex, METABOLITES, CONTROL (Psychology), DRUG abusers
Abstract

Alcohol use disorder (AUD) has been shown to have harmful cognitive and physiological effects, including altered brain chemistry. Further, although men and women may differ in vulnerability to the neurobiological effects of AUD, the results of existing studies have been conflicting. We examined brain metabolite levels and cognitive functions in a cross-section of men with AUD (AUDm) and women with AUD (AUDw) to determine the degree of abnormalities after extended periods of abstinence (mean, 6 years) and to evaluate gender differences in neuropsychological and metabolite measures. Participants were 40 abstinent individuals with AUD (22 AUDw, 18 AUDm) and 50 age-equivalent non-AUD comparison participants (26 NCw, 24 NCm). Proton magnetic resonance spectroscopy (MRS) was employed at 3 Tesla to acquire metabolite spectra from the dorsal anterior cingulate cortex (dACC). Brain metabolites N-acetyl aspartate (NAA), choline (Cho), myo-Inositol (mI), and glutamate & glutamine (Glx) were examined relative to measures of memory and inhibitory control. Metabolite levels did not differ significantly between AUD and NC groups. Memory and inhibitory-control impairments were observed in the AUD group. There also were significant group-specific associations between metabolite ratios and measures of inhibitory control. There were no group-by-gender interactions for the four metabolite ratios. These findings demonstrate that brain metabolite levels in men and women with AUD, following long-term abstinence, do not differ from individuals without AUD. The data also provide preliminary evidence of sustained associations between metabolite levels and measures of inhibitory control, a functional domain important for curtailing harmful drinking. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Forgiveness Mediates the Relationship Between Middle Frontal Gyrus Volume and Clinical Symptoms in Adolescents

Author

Schuttenberg, Eleanor M., Sneider, Jennifer T., Rosmarin, David H., Cohen-Gilbert, Julia E., Oot, Emily N., Seraikas, Anna M., Stein, Elena R., Maksimovskiy, Arkadiy L., Harris, Sion K., and Silveri, Marisa M.

Subjects
Behavioral Neuroscience, Psychiatry and Mental health, Neuropsychology and Physiological Psychology, Neurology, Biological Psychiatry
Abstract

Dispositional forgiveness is positively associated with many facets of wellbeing and has protective implications against depression and anxiety in adolescents. However, little work has been done to examine neurobiological aspects of forgiveness as they relate to clinical symptoms. In order to better understand the neural mechanisms supporting the protective role of forgiveness in adolescents, the current study examined the middle frontal gyrus (MFG), which comprises the majority of the dorsolateral prefrontal cortex (DLPFC) and is associated with cognitive regulation, and its relationship to forgiveness and clinical symptoms in a sample of healthy adolescents. In this cross-sectional study (n = 64), larger MFG volume was significantly associated with higher self-reported dispositional forgiveness scores and lower levels of depressive and anxiety symptoms. Forgiveness mediated the relationship between MFG volume and both depressive and anxiety symptom levels. The mediating role of forgiveness in the relationship between MFG volume and clinical symptoms suggests that one way that cognitive regulation strategies supported by this brain region may improve adolescent mental health is via increasing a capacity for forgiveness. The present study highlights the relevance of forgiveness to neurobiology and their relevance to emotional health in adolescents. Future longitudinal studies should focus on the predictive quality of the relationship between forgiveness, brain volume and clinical symptoms and the effects of forgiveness interventions on these relationships.

Published
2021

20. Clinical Outcomes Following Acute Residential Psychiatric Treatment in Transgender and Gender Diverse Adolescents

Author

Silveri, Marisa M., primary, Schuttenberg, Eleanor M., additional, Schmandt, Kaya, additional, Stein, Elena R., additional, Rieselbach, Maya M., additional, Sternberg, Ariel, additional, Cohen-Gilbert, Julia E., additional, Katz-Wise, Sabra L., additional, Blackford, Jennifer Urbano, additional, Potter, Alexandra S., additional, Potter, Mona P., additional, Sarvey, Dana B., additional, McWhinnie, Chad M., additional, Feinberg, Jessica E., additional, and Boger, Kathryn D., additional

Published
2021
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