Search

Your search keyword '"Silveira, Douglas R. A."' showing total 19 results
Start Over Author "Silveira, Douglas R. A."
19 results on '"Silveira, Douglas R. A."'

3. Combining gene mutation with gene expression analysis improves outcome prediction in acute promyelocytic leukemia

Author

Lucena-Araujo, Antonio R., Coelho-Silva, Juan L., Pereira-Martins, Diego A., Silveira, Douglas R., Koury, Luisa C., Melo, Raul A.M., Bittencourt, Rosane, Pagnano, Katia, Pasquini, Ricardo, Nunes, Elenaide C., Fagundes, Evandro M., Gloria, Ana B., Kerbauy, Fábio, de Lourdes Chauffaille, Maria, Bendit, Israel, Rocha, Vanderson, Keating, Armand, Tallman, Martin S., Ribeiro, Raul C., Dillon, Richard, Ganser, Arnold, Löwenberg, Bob, Valk, P.J.M., Lo-Coco, Francesco, Sanz, Miguel A., Berliner, Nancy, and Rego, Eduardo M.

Published
2019
Full Text
View/download PDF

4. NTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia

Author

Thomé, Carolina Hassibe, Ferreira, Germano Aguiar, Pereira-Martins, Diego Antonio, dos Santos, Guilherme Augusto, Ortiz, César Alexander, de Souza, Lucas Eduardo Botelho, Sobral, Lays Martins, Silva, Cleide Lúcia Araújo, Scheucher, Priscila Santos, Gil, Cristiane Damas, Leopoldino, Andréia Machado, Silveira, Douglas R. A., Coelho-Silva, Juan L., Traina, Fabíola, Koury, Luisa C., Melo, Raul A. M., Bittencourt, Rosane, Pagnano, Katia, Pasquini, Ricardo, Nunes, Elenaide C., Fagundes, Evandro M., Gloria, Ana Beatriz F., Kerbauy, Fábio Rodrigues, Chauffaille, Maria de Lourdes, Keating, Armand, Tallman, Martin S., Ribeiro, Raul C., Dillon, Richard, Ganser, Arnold, Löwenberg, Bob, Valk, Peter, Lo-Coco, Francesco, Sanz, Miguel A., Berliner, Nancy, Faça, Vitor Marcel, and Rego, Eduardo M.

Published
2020
Full Text
View/download PDF

5. M2 macrophages drive leukemic transformation by imposing resistance to phagocytosis and improving mitochondrial metabolism

Author

Weinhäuser, Isabel, primary, Pereira-Martins, Diego A., additional, Almeida, Luciana Y., additional, Hilberink, Jacobien R., additional, Silveira, Douglas R. A., additional, Quek, Lynn, additional, Ortiz, Cesar, additional, Araujo, Cleide L., additional, Bianco, Thiago M., additional, Lucena-Araujo, Antonio, additional, Mota, Jose Mauricio, additional, Hogeling, Shanna M., additional, Sternadt, Dominique, additional, Visser, Nienke, additional, Diepstra, Arjan, additional, Ammatuna, Emanuele, additional, Huls, Gerwin, additional, Rego, Eduardo M., additional, and Schuringa, Jan Jacob, additional

Published
2023
Full Text
View/download PDF

6. Clinical significance of mitochondrial DNA content in acute promyelocytic leukaemia

Author

Pereira‐Martins, Diego A., primary, Coelho‐Silva, Juan L., additional, Weinhäuser, Isabel, additional, Franca‐Neto, Pedro L., additional, Silveira, Douglas R., additional, Ortiz, César, additional, Moreira‐Aguiar, Amanda, additional, Lima, Marinus M., additional, Koury, Luisa C., additional, de Melo, Raul A., additional, Glória, Ana B., additional, Fagundes, Evandro M., additional, Lino, Bruno K., additional, Pagnano, Katia, additional, Bittencourt, Rosane, additional, Nunes, Elenaide, additional, Traina, Fabiola, additional, Figueiredo‐Pontes, Lorena, additional, Keating, Armand, additional, Tallman, Martin S., additional, Ribeiro, Raul C., additional, Dilon, Richard, additional, Ganser, Arnold, additional, Sanz, Miguel A., additional, Berliner, Nancy, additional, Valk, Peter, additional, Löwenberg, Bob, additional, Ottone, Tiziana, additional, Noguera, Nelida I., additional, Voso, Maria T., additional, Paoloni, Francesca, additional, Fazi, Paola, additional, Ammatuna, Emanuele, additional, Huls, Gerwin, additional, Schuringa, Jan Jacob, additional, Rego, Eduardo M., additional, and Lucena‐Araujo, Antonio R., additional

Published
2022
Full Text
View/download PDF

7. Clinical significance of mitochondrial DNA content in acute promyelocytic leukaemia.

Author

Pereira‐Martins, Diego A., Coelho‐Silva, Juan L., Weinhäuser, Isabel, Franca‐Neto, Pedro L., Silveira, Douglas R., Ortiz, César, Moreira‐Aguiar, Amanda, Lima, Marinus M., Koury, Luisa C., de Melo, Raul A., Glória, Ana B., Fagundes, Evandro M., Lino, Bruno K., Pagnano, Katia, Bittencourt, Rosane, Nunes, Elenaide, Traina, Fabiola, Figueiredo‐Pontes, Lorena, Keating, Armand, and Tallman, Martin S.

Subjects
ACUTE promyelocytic leukemia, MITOCHONDRIAL DNA, PROPORTIONAL hazards models
Abstract

Summary: Although a growing body of evidence demonstrates that altered mtDNA content (mtDNAc) has clinical implications in several types of solid tumours, its prognostic relevance in acute promyelocytic leukaemia (APL) patients remains largely unknown. Here, we show that patients with higher‐than‐normal mtDNAc had better outcomes regardless of tumour burden. These results were more evident in patients with low‐risk of relapse. The multivariate Cox proportional hazard model demonstrated that high mtDNAc was independently associated with a decreased cumulative incidence of relapse. Altogether, our data highlights the possible role of mitochondrial metabolism in APL patients treated with ATRA. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

8. Co-occurrence of DNMT3A, NPM1, FLT3 mutations identifies a subset of acute myeloid leukemia with adverse prognosis

Author

Bezerra, Matheus F., Lima, Aleide S., Piqué-Borràs, Maria-Riera, Silveira, Douglas R., Coelho-Silva, Juan L., Pereira-Martins, Diego A., Weinhäuser, Isabel, Franca-Neto, Pedro L., Quek, Lynn, Corby, Anna, Oliveira, Mayara M., Lima, Marinus M., de Assis, Reijane A., de Melo Campos, Paula, Duarte, Bruno K., Bendit, Israel, Rocha, Vanderson, Rego, Eduardo M., Traina, Fabiola, Saad, Sara T., Beltrão, Eduardo I., Bezerra, Marcos A., and Lucena-Araujo, Antonio R.

Published
2020
Full Text
View/download PDF

10. Reduced SLIT2 is Associated with Increased Cell Proliferation and Arsenic Trioxide Resistance in Acute Promyelocytic Leukemia

Author

Weinhäuser, Isabel, primary, Pereira-Martins, Diego A., additional, Ortiz, Cesar, additional, Silveira, Douglas R., additional, Simões, Luíse A. A., additional, Bianco, Thiago M., additional, Araujo, Cleide L., additional, Koury, Luisa C., additional, Melo, Raul A. M., additional, Bittencourt, Rosane I., additional, Pagnano, Katia, additional, Pasquini, Ricardo, additional, Nunes, Elenaide C., additional, Fagundes, Evandro M., additional, Gloria, Ana B., additional, Kerbauy, Fábio, additional, Chauffaille, Maria de Lourdes, additional, Keating, Armand, additional, Tallman, Martin S., additional, Ribeiro, Raul C., additional, Dillon, Richard, additional, Ganser, Arnold, additional, Löwenberg, Bob, additional, Valk, Peter, additional, Lo-Coco, Francesco, additional, Sanz, Miguel A., additional, Berliner, Nancy, additional, Ammatuna, Emanuele, additional, Lucena-Araujo, Antonio R., additional, Schuringa, Jan Jacob, additional, and Rego, Eduardo M., additional

Published
2020
Full Text
View/download PDF

11. A multicenter comparative acute myeloid leukemia study: can we explain the differences in the outcomes in resource-constrained settings?

Author

Silveira, Douglas R. A., primary, Coelho-Silva, Juan L., additional, Silva, Wellington F., additional, Vallance, Grant, additional, Pereira-Martins, Diego A., additional, Madeira, Maria I. A., additional, Figueredo-Pontes, Lorena L., additional, Velloso, Elvira D. R. P., additional, Simões, Belinda P., additional, Peniket, Andy, additional, Danby, Robert, additional, Rego, Eduardo M., additional, Vyas, Paresh, additional, Traina, Fabiola, additional, Bendit, Israel, additional, Quek, Lynn, additional, and Rocha, Vanderson, additional

Published
2020
Full Text
View/download PDF

12. Integrating clinical features with genetic factors enhances survival prediction for adults with acute myeloid leukemia

Author

Silveira, Douglas R. A., primary, Quek, Lynn, primary, Santos, Itamar S., primary, Corby, Anna, primary, Coelho-Silva, Juan L., primary, Pereira-Martins, Diego A., primary, Vallance, Grant, primary, Brown, Benjamin, primary, Nardinelli, Luciana, primary, Silva, Wellington F., primary, Velloso, Elvira D. R. P., primary, Lucena-Araujo, Antonio R., primary, Traina, Fabiola, primary, Peniket, Andy, primary, Vyas, Paresh, primary, Rego, Eduardo M., primary, Bendit, Israel, primary, and Rocha, Vanderson, primary

Published
2020
Full Text
View/download PDF

13. Combining Clinical Features with Genetic Factors Improves Survival Prediction for Adults with Acute Myeloid Leukemia: Validation of a New Score System in 3 Cohorts

Author

Silveira, Douglas R. A., primary, Quek, Lynn, additional, Corby, Anna, additional, Coelho-Silva, Juan L, additional, Pereira-Martins, Diego A, additional, Vallance, Grant, additional, Brown, Benjamin, additional, Nardinelli, Luciana, additional, Silva, Wellington F, additional, Velloso, Elvira DRP, additional, Traina, Fabiola, additional, Peniket, Andy, additional, Vyas, Paresh, additional, Rego, Eduardo M, additional, Bendit, Israel, additional, and Rocha, Vanderson, additional

Published
2019
Full Text
View/download PDF

14. Molecular-Based Score Inspired on Metabolic Signature Improves Prognostic Stratification for Myelodysplastic Syndrome

Author

Coelho-Silva, Juan L, primary, Silveira, Douglas R. A., additional, Pereira-Martins, Diego A, additional, Ortiz Rojas, César Alexander, additional, Lucena-Araujo, Antonio R., additional, Rego, Eduardo M, additional, Machado-Neto, João Agostinho, additional, Bendit, Israel, additional, Rocha, Vanderson, additional, and Traina, Fabiola, additional

Published
2019
Full Text
View/download PDF

16. Association betweenANXA2*5681 polymorphism (rs7170178) and osteonecrosis in haemoglobin SS‐genotyped patients

Author

Pereira‐Martins, Diego A., primary, Coelho‐Silva, Juan L., additional, Domingos, Igor F., additional, Weinhäuser, Isabel, additional, Silveira, Douglas R., additional, Cunha, Anderson F., additional, Franca‐Neto, Pedro L., additional, Franca, Rafael F., additional, Costa, Fernando F., additional, Araújo, Aderson S., additional, Lucena‐Araujo, Antonio R., additional, and Bezerra, Marcos A., additional

Published
2019
Full Text
View/download PDF

17. A multicenter comparative acute myeloid leukemia study: can we explain the differences in the outcomes in resource-constrained settings?

Author

Silveira, Douglas R. A., Coelho-Silva, Juan L., Silva, Wellington F., Vallance, Grant, Pereira-Martins, Diego A., Madeira, Maria I. A., Figueredo-Pontes, Lorena L., Velloso, Elvira D. R. P., Simões, Belinda P., Peniket, Andy, Danby, Robert, Rego, Eduardo M., Vyas, Paresh, Traina, Fabiola, Bendit, Israel, Quek, Lynn, and Rocha, Vanderson

Subjects
*ACUTE myeloid leukemia, *GRAM-negative bacterial diseases, *STEM cell transplantation, *HEMATOPOIETIC stem cells, *INFECTION prevention
Abstract

Outcomes in acute myeloid leukemia (AML) are dependent on patient- and disease-characteristics, treatment, and socioeconomic factors. AML outcomes between resource-constrained and developed countries have not been compared directly. We analyzed two cohorts: from São Paulo state, Brazil (USP, n = 312) and Oxford, United Kingdom (OUH, n = 158). USP cohort had inferior 5-year overall survival compared with OUH (29% vs. 49%, adjusted-p=.027). USP patients have higher early-mortality (23% vs. 6% p<.001) primarily due to multi-resistant Gram-negative bacterial and fungal infections. USP had higher 5-year cumulative incidence of relapse (60% vs. 50%, p=.0022), were less likely to undergo hematopoietic stem cell transplant (HSCT) (28% vs. 75%, p<.001) and waited longer for HSCT (median, 23.8 vs. 7.2 months, p<.001). Three-year survival in relapsed patients was worse in USP than OUH (10% vs. 39%, p<.001). Our study indicates that efforts to improve AML outcomes in Brazil should focus on infection prevention and control, and access to HSCT. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

18. Co-occurrence of DNMT3A, NPM1, FLT3mutations identifies a subset of acute myeloid leukemia with adverse prognosis

Author

Bezerra, Matheus F., Lima, Aleide S., Piqué-Borràs, Maria-Riera, Silveira, Douglas R., Coelho-Silva, Juan L., Pereira-Martins, Diego A., Weinhäuser, Isabel, Franca-Neto, Pedro L., Quek, Lynn, Corby, Anna, Oliveira, Mayara M., Lima, Marinus M., de Assis, Reijane A., de Melo Campos, Paula, Duarte, Bruno K., Bendit, Israel, Rocha, Vanderson, Rego, Eduardo M., Traina, Fabiola, Saad, Sara T., Beltrão, Eduardo I., Bezerra, Marcos A., and Lucena-Araujo, Antonio R.

Published
2020
Full Text
View/download PDF

19. Association between ANXA2*5681 polymorphism (rs7170178) and osteonecrosis in haemoglobin SS‐genotyped patients.

Author

Pereira‐Martins, Diego A., Coelho‐Silva, Juan L., Domingos, Igor F., Weinhäuser, Isabel, Silveira, Douglas R., Cunha, Anderson F., Franca‐Neto, Pedro L., Franca, Rafael F., Costa, Fernando F., Araújo, Aderson S., Lucena‐Araujo, Antonio R., and Bezerra, Marcos A.

Subjects
OSTEONECROSIS, HEMOGLOBINS
Abstract

Recurrent vaso-occlusive crises resulting in bone infarction constitute the main cause of osteonecrosis in patients with sickle cell anaemia (SCA) (da Silva Junior I et al., i [10]). Patients with ANXA2*5681 AA genotype (22%, 95% CI: 16-31%) had a significantly higher osteonecrosis development rate compared to patients with non-AA genotype (6%, 95% CI: 4-11%) (P < 0-0001). Genetic assessment of the ANXA2*5681 polymorphism (rs7170178) distribution revealed 44/85 patients (52%) harbouring the ANXA2*5681 non-AA genotype and 41/85 (48%) carrying the ANXA2*5681 AA genotype. To examine the biological impact of I ANXA2 i *5681 polymorphism (rs7170178) at the transcriptional and translational levels, we evaluated 85 new freshly collected samples from patients with SCA who developed (26 patients) or did not develop (59 patients) osteonecrosis. [Extracted from the article]

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results