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Since the beginning of the COVID-19 pandemic, many works have been published proposing solutions to the problems that arose in this scenario. In this vein, one of the topics that attracted the most attention is the development of computer-based strategies to detect COVID-19 from thoracic medical imaging, such as chest X-ray (CXR) and computerized tomography scan (CT scan). By searching for works already published on this theme, we can easily find thousands of them. This is partly explained by the fact that the most severe worldwide pandemic emerged amid the technological advances recently achieved, and also considering the technical facilities to deal with the large amount of data produced in this context. Even though several of these works describe important advances, we cannot overlook the fact that others only use well-known methods and techniques without a more relevant and critical contribution. Hence, differentiating the works with the most relevant contributions is not a trivial task. The number of citations obtained by a paper is probably the most straightforward and intuitive way to verify its impact on the research community. Aiming to help researchers in this scenario, we present a review of the top-100 most cited papers in this field of investigation according to the Google Scholar search engine. We evaluate the distribution of the top-100 papers taking into account some important aspects, such as the type of medical imaging explored, learning settings, segmentation strategy, explainable artificial intelligence (XAI), and finally, the dataset and code availability. [ABSTRACT FROM AUTHOR]

Recent studies have been evaluating the presence of patterns associated with the occurrence of cancer in different types of tissue present in the individual affected by the disease. In this article, we describe preliminary results for the automatic detection of cancer (Walker 256 tumor) in laboratory animals using preclinical microphotograph images of the subject's liver tissue. In the proposed approach, two different types of descriptors were explored to capture texture properties from the images, and we also evaluated the complementarity between them. The first texture descriptor experimented is the widely known Local Phase Quantization (LPQ), which is a descriptor based on spectral information. The second one is built by the application of a granulometry given by a family of morphological filters. For classification, we have evaluated the algorithms Support Vector Machine (SVM), k-Nearest Neighbor (k-NN) and Logistic Regression. Experiments carried out on a carefully curated dataset developed by the Enteric Neural Plasticity Laboratory of the State University of Maringá showed that both texture descriptors provide good results in this scenario. The accuracy rates obtained using the SVM classifier were 96.67% for the texture operator based on granulometry and 91.16% for the LPQ operator. The dataset was made available also as a contribution of this work. In addition, it is important to remark that the best overall result was obtained by combining classifiers created using both descriptors in a late fusion strategy, achieving an accuracy of 99.16%. The results obtained show that it is possible to automatically perform the identification of cancer in laboratory animals by exploring texture properties found on the tissue taken from the liver. Moreover, we observed a high level of complementarity between the classifiers created using LPQ and granulometry properties in the application addressed here. [ABSTRACT FROM AUTHOR]

Background/aims: p53 is a transcriptional factor that responds to severe cell damage promoting the transcription of proapoptotic and prooxidant genes. In this study, we evaluated the role of p53 activation in glycerol-induced acute kidney injury (Gly-AKI).Methods: Rats were treated with p53 inhibitor (pifithrin-α) in the moment we injected glycerol. Renal function, renal histology (HE), TUNEL labeling, cleaved caspase-3 staining, renal p53, Bax, PUMA, Bcl-2, p21 and survivin expressions, renal lipid and DNA oxidative markers, and the expression of antioxidant enzymes (Mn-SOD, HO-1, and NAD(P)H:quinone-oxidoreductase-1) were evaluated.Results: Gly-AKI rats showed an increased renal expression of phosphorylated-p53. The p53 inhibitor attenuated renal impairment and significantly reduced tubular injury. The expression of the oxidative markers was significantly reduced in treated rats. Proapoptotic and prooxidant proteins Bax and PUMA were overexpressed in Gly-AKI rats and reduced in treated rats. On the contrary, antiapoptotic Bcl-2, p21, and survivin showed a tendency to increase in treated rats. The antioxidant enzymes' expression remained elevated or increased in treated rats.Conclusion: On the whole, p53 inhibition was protective in the short term. The oxidative stress subsided and the transcription tipped toward prosurvival genes; consequently tubular injury was attenuated in treated rats. [ABSTRACT FROM AUTHOR]