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1. Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial

Author: Abdelhamid, N, Abdul Rahman, D, Abdul-Saheb, M, Abreu, P, Abroskina, M, Abu Ahmad, F, Accassat, S, Acciaresi, M, Adami, A, Ahmad, N, Ahmed, F, Alberto Hawkes, M, Alemseged, F, Ali, A, Altavilla, R, Alwis, L, Amarenco, P, Amaro, S, Amaya Sanchez, LE, Amelia Pinto, A, Ameriso, SF, Amin, H, Amino, T, Amjad, AK, Anagnostou, E, Andersen, G, Anderson, C, Anderson, DC, Andrea Falco, M, Andres Mackinnon, F, Andreu, D, Androulakis, M, Angel Gamero, M, Angel Saredo, G, Angeles Diaz, R, Angels Font, M, Anticoli, S, Arauz, A, Arauz Gongora, AA, Araya, P, Arenillas Lara, JF, Arias Rivas, S, Arnold, M, Augustin, S, Avelar, W, Azevedo, E, Babikian, V, Bacellar, A, Badalyan, K, Bae, HJ, Baez Martinez, EM, Bagelmann, H, Bailey, P, Bak, Z, Baker, M, Balazs, A, Baldaranov, D, Balogun, I, Balueva, T, Bankuti, Z, Bar, M, Baranowska, A, Bardutzky, J, Barker Trejo, S, Barlinn, J, Baronnet, F, Barroso, C, Barteys, M, Bartolottiova, T, Barulin, A, Bas, M, Bashir, S, Basile, V, Bathe-Peters, R, Bathula, R, Batista, C, Batur Caglayan, H, Baumgartner, P, Bazan, R, Bazhenova, O, Beaudry, M, Beer, J, Behnam, Y, Beilei, C, Beinlich, A, Bejot, Y, Belkin, A, Benavente, OR, Benjamin, A, Berardi, V, Bereczki, D, Berkowitz, SD, Berlingieri, J, Berrios, W, Berrouschot, J, Bhandari, M, Bhargavah, M, Bicker, H, Bicsak, T, Bilik, M, Bindila, D, Birchenall, J, Birnbaum, L, Black, T, Blacker, D, Blacquiere, D, Blanc-Labarre, C, Blank, C, Blazejewska-Hyzorek, B, Bloch, S, Bodiguel, E, Bogdanov, E, Boos, L, Borcsik, L, Bornstein, N, Bouly, S, Braga, G, Bragado, I, Bravi, MC, Brokalaki, C, Brola, W, Brouns, R, Bruce, D, Brzoska-Mizgalska, J, Buck, B, Buksinska-Lisik, M, Burke, J, Burn, M, Bustamante, G, Cabrejo, L, Cai, K, Cajaraville, S, Calejo, M, Calvet, D, Campillo, J, Campos Costa, E, Camps, P, Can Alaydin, H, Candeloro, E, Canepa, C, Cantu Brito, CG, Cappellari, M, Carcel, C, Cardona Portela, P, Cardoso, F, Carek, M, Carletti, M, Carlos Portilla, J, Caruso, P, Casado-Naranjo, I, Castellini, P, Castro, D, Castro Meira, F, Cavallini, A, Cayuela Caudevilla, N, Cenciarelli, S, Cereda, C, Cerrone, P, Chakrabarti, A, Chaloulos-Iakovidis, P, Chamorro, A, Chandrasena, D, Chang, DI, Che, C, Chembala, J, Chen, J, Chen, Z, Chen, T, Chen, H, Chen, X, Chen, G, Chen, L, Chen, S, Cheripelli, B, Chin, M, Chiquete Anaya, E, Chorazy, M, Christensen, H, Christensen, T, Christian, L, Chu, F, Chung, CS, Clark, W, Clarke, R, Claverie, S, Clemente Agostoni, E, Clissold, B, Coelho, J, Cohen, D, Colakoglu, S, Collas, D, Condurso, R, Connolly, SJ, Consoli, D, Constantin, C, Constantino Silva, AB, Contardo, L, Corlobe, A, Correia, M, Correia, C, Cortijo Garcia, E, Coull, B, Coutts, S, Coveney, S, Cras, P, Crols, R, Crozier, S, Csanyi, A, Csiba, L, Csontos, K, Csuha, R, Cui, L, Cunha, L, Curtze, S, Czerska, M, Czlonkowska, A, Czurko, M, Czuryszkiewicz, M, Dagnino, M, Dai, C, Daineko, A, Dalek, G, Damgaard, D, Danese, A, Dani, K, Danku, V, Dario Toledo, W, Dávalos, A, De Havenon, A, De Keyser, J, De Klippel, N, De La Torre, J, De Pauw, A, De Smedt, A, De Torres, R, De Vries Basson, MM, Dearborn, J, Deganutto, R, Degeorgia, M, Deguchi, I, Del Giudice, A, Delcourt, C, Delgado-Mederos, R, Della Marca, G, Delpont, B, Deltour, S, Demets, DL, Dennis, M, Desai, J, Devine, J, Dhollander, I, Di Mascio, MT, Diaconu, M, Diaz Otero, F, Dietzel, J, Diez-Tejedor, E, Ding, N, Ding, J, Diomedi, M, Dioszeghy, P, Distefano, M, Domigo, V, Dorodnicov, E, Dossi, D, Doubal, F, Druzenko, I, Du, P, Du, J, Duman, T, Duodu, Y, Dutta, D, Dylewicz, L, Eckstein, J, Ehrensperger, E, Ehrlich, S, Einer Allende, G, Elena Halac, B, Elyas, S, Endres, M, Engelbrecht, JM, Engelter, S, Epinat, M, Eren, F, Esbjornsson, M, Escribano, B, Escudero, I, Esisi, B, Essa, B, Esterbauer, M, Evans, N, Eveson, D, Fabio, S, Fang, L, Fanta, S, Fares, M, Fatar, M, Faust, K, Favate, A, Fazekas, F, Federica Denaro, M, Fedin, A, Felipe Amaya, P, Feng, J, Ferencova, K, Fernanda Gilli, M, Fernandez, MD, Fernandez Pirrone, PN, Fernandez Vera, J, Ferrari, J, Ferreira, A, Ferreira Junior, G, Fidler, M, Field, D, Field, T, Figueroa, C, Fiksa, J, Filipov, A, Firstenfeld, A, Fisch, L, Fischer, U, Fisselier, M, Fiszer, U, Fluri, F, Fortea, G, Fotherby, K, Fraczek, A, France, E, Freitas, G, Frey, S, Frick, M, Friedman, A, Friedrich, M, Frisullo, G, Fryze, W, Fuentes Gimeno, B, Fujigasaki, H, Fukuyama, K, Furlan, A, Furlanis, G, Furnace, J, Gabriel, M, Gabriel Reich, E, Gagliardi, RJ, Galati, F, Galli Giqueauk, E, Gallina, A, Gallinella, E, Gallo, J, Gangadharan, S, Gao, Y, Garcia Lopez, R, Garcia Pastor, A, Garcia Sanchez, SM, Garnauf, M, Garnier, P, Gasecki, D, Gasic, K, Gasiorek, K, Gasser, S, Gaugg, M, Gebreyohanns, M, Gebura, K, Geng, J, Geniz Clavijo, M, Georg Haeusler, K, Geran, R, Geremek, M, Gerocs, Z, Ghia, D, Giannandrea, D, Giatsidis, F, Gien Lopez, JA, Gil Nunez, A, Gimenez, L, Giralt, E, Glabinski, A, Gladstone, D, Gliem, M, Gluszkiewicz, M, Goddeau, R, Gogoleva, E, Gokce, M, Goldemund, D, Golikov, K, Gomes Neto, A, Gomez Schneider, M, Gomez-Choco, M, Gomis, M, Gongora-Rivera, JF, Gonysheva, Y, Gonzalez, L, Gonzalez Toledo, ME, Gottschal, M, Gozdzik, I, Grabowski, S, Graf, S, Green, D, Greer, D, Gregorio, T, Greisenegger, S, Greshnova, I, Griebe, M, Grzesik, M, Guan, J, Guarda, S, Gueguen, A, Guidoux, C, Guillermo Povedano, P, Guillon, B, Guiraudg, V, Gunathilagan, G, Guryanova, N, Gusev, V, Gustavo Persi, G, Gutiérrez, R, Guyler, P, Gyuker, N, Hachinski, V, Hajas, A, Hallevi, H, Hankey, G, Hankey, GJ, Hanouskova, L, Hao, L, Haraguchi, K, Haralur Sreekantaiah, Y, Haratz, S, Hargroves, D, Harkness, K, Harmel, P, Harrasser, M, Hart, RG, Harvey, M, Hasan, R, Hasegawa, Y, Hassan, A, Hattori, M, Hatzitolios, A, Hauk, M, Hayashi, T, Hayhoe, H, Hedna, VS, Heine, M, Held, V, Hellwig, S, Henkner, J, Henninger, N, Hermans, S, Hernandez, J, Herrero, D, Hervieu-Begue, M, Herzig, R, Hicken, L, Hieber, M, Hill, M, Hirose, M, Hobeanu, MC, Hobson, B, Hochstetter, M, Hoe Heo, J, Hoffmann, M, Holmstedt, C, Hon, P, Hong, KS, Honma, Y, Horev, A, Horgan, G, Horvath, L, Horvath, M, Hoyer, C, Huang, D, Huang, H, Huber, B, Huhtakangas, J, Hussain, M, Igarashi, S, Iglesias Mohedano, AM, Ignacio Tembl, J, Impellizzeri, M, Inanc, Y, Ioli, P, Irina Aniculaesei, A, Ishida, K, Itabashi, R, Iversen, H, Jagolino, A, Jakab, K, Jander, S, Janka, H, Jankovych, J, Jansen, J, Jasek, L, Javier Alet, M, Javor, L, Jin, X, Jing, P, Joachim, B, Joan Macleod, M, Johnson, M, Jose Martin, J, Joyner, C, Judit Szabo, K, Jun-Oconnell, A, Jura, R, Kaczorowska, B, Kadlcikova, J, Kahles, T, Kakaletsis, N, Kakuk, I, Kalinowska, K, Kaminska, K, Kaneko, C, Kanellos, I, Kapeller, P, Kapica-Topczewska, K, Karasz, O, Karlinski, M, Karlsson, JE, Kasa, K, Kashaeva, E, Kasner, SE, Kaste, M, Kasza, J, Katalin Iljicsov, A, Katsurayama, M, Kaur, S, Kawanishi, M, Kaygorodtseva, S, Ke, K, Kei, A, Keilitz, J, Kellner, J, Kelly, P, Kelly, S, Kemlink, D, Kerekgyarto, M, Keskinarkaus, I, Khairutdinova, D, Khanna, A, Khaw, A, Kholopov, M, Khoumri, C, Kirpicheva, S, Kirshner, H, Kitagawa, K, Kittner, S, Kivioja, R, Klein, F, Kleindorfer, D, Kleinig, T, Klivenyi, P, Knecht, S, Kobayashi, Y, Kobayashi, A, Koch, M, Koehler, L, Koivu, M, Kolianov, V, Koltsov, I, Kondo, T, Konkov, I, Kopecky, S, Korompoki, E, Korpela, J, Kosarz-Lanczek, K, Koutroubi, A, Kovacs, K, Kovacs, T, Kovacs, H, Kowalczyk, K, Kowalska, M, Krajickova, D, Kral, M, Krarup Hansen, C, Kraska, J, Krebs, S, Krejci, V, Kremer, C, Kreuzpointer, R, Krzyzanowska, M, Kucken, D, Kulakowska, A, Kunzmann, J, Kurenkova, N, Kuris, A, Kurkowska-Jastrzebska, I, Kurtenkova, N, Kurushina, O, Kusnick, G, Kustova, M, Kuwashiro, T, Kwan Cha, J, Lago, A, Lagutenko, M, Lajos, B, Lambeck, J, Lamy, C, Landolfi, A, Lanfranconi, S, Lang, W, Lara Lezama, LB, Lara Rodriguez, B, Largo, T, Lasek-Bal, A, Latte, L, Lauer, V, Lavados, P, Le Bouc, R, Leal Cantu, R, Lechner, H, Lecouturier, K, Leder, S, Lee, J, Lee, BC, Leger, A, Leira, E, Leisse, I, Leker, R, Lembo, G, Lenskaya, L, Leyden, J, Li, G, Li, M, Li, S, Li, J, Liamis, G, Liang, H, Liang, Z, Ligot, N, Lin, H, Lindert, R, Lindgren, A, Linna, M, Litwin, T, Liu, K, Liu, X, Llull, L, Lohninger, B, Longoni, M, Loomis, C, Lopes, D, Lopez Fernandez, M, Lopez Garza, N, Lord, A, Louw, S, Lovasz, R, Lowenkopf, T, Lu, Z, Lubke-Detring, SC, Luder, R, Lujan, S, Luo, B, Lupinogina, L, Luschin, G, Lutsep, H, Lvova, A, Ly, J, Grosse, G.M., Ma, H, Ma, C, Machado, M, Machado, C, Macher, S, Machetanz, J, Macian-Montoro, F, Mackey, E, Mackey, A, Maclean, G, Maestre-Moreno, J, Magadan, A, Magyar, T, Mahagney, A, Majid, A, Majjhoo, A, Makaritsis, K, Mandzia, J, Mangas Guijarro, M, Mangion, D, Manios, E, Mann, S, Manning, L, Manno, C, Manuel Garcia, J, Maqueda, V, Mar Castellanos, M, Mar Freijo, M, Marando, C, Marcela Lepera, S, Marcos Couto, J, Maria Bruera, G, Maria Greco, L, Maria Lorenzo, A, Maria Obmann, S, Maria Roa, A, Marini, C, Marinkovic, I, Mario Sumay, G, Mario Torres, C, Marko, M, Markova, S, Markus, H, Marsh, R, Marsili, E, Marta Esnaola, M, Marta Moreno, J, Marti-Fabregas, J, Martina Angelocola, S, Martínez Sánchez, P, Martinez-Majander, N, Martins, S, Marzelik, O, Mastrocola, S, Matamala, G, Matoltsy, A, Matosevic, B, Matsumoto, S, Maud, A, Mauri Cabdevila, G, May, Z, Mayasi, Y, Mayr, A, Mazzoli, T, Mcarthur, K, Mccullough, L, Medina Pech, CE, Medlin, F, Mehdiratta, M, Mehta, S, Mehta, D, Mehta, B, Melis, M, Melnikova, E, Mendez, B, Mendonca, T, Mengual Chirifie, JJ, Menon, N, Mensch, A, Meseguer, E, Messe, S, Metcalf, K, Meyer, N, Michas, F, Micheletti, N, Mikulik, R, Milionis, H, Miller, B, Milling, T, Minelli, C, Minhas, J, Minns, M, Mircea, D, Mishra, S, Mismas, A, Mistri, A, Mitrovic, N, Miyake, H, Modrau, B, Moey, A, Molina, C, Molina, J, Molis, A, Moller, J, Molnar, S, Moniche, F, Monosi, C, Monzani, V, Moonis, M, Morais, R, Morales, L, Morales, A, Morar-Precup, D, Moreton, F, Moro, C, Morozova, E, Morton, M, Morvan, T, Morvan, E, Motko, T, Mowla, A, Mozhejko, E, Muddegowda, G, Mudhar, O, Mueller, T, Muhl, C, Muir, KW, Mundl, H, Munoz, S, Murphy, C, Murphy, S, Murtuzova, A, Musuka, T, Mutzenbach, J, Myint, M, Mysliwy, W, Naccarato, M, Naeije, G, Nagakane, Y, Natarajan, I, Navaratnam, D, Nave, A, Nazliel, B, Nedeltchev, K, Nel, J, Nell, H, Nemeth, R, Nemeth, L, Neto, O, Ng, K, Ngeh, J, Nicolas Chialvo, L, Nieminen, T, Nikkanen, M, Nikl, J, Nikoforova, M, Nishino, S, Nishiyama, Y, Njovane, X, Nogawa, S, Nombela, F, Norrving, B, Nosek, K, Nowak, B, Nowakowska-Sledz, E, Ntaios, G, Numminen, H, Nunez, F, Obadia, M, Oberndorfer, S, Obrezan, A, Ochiai, J, Oczkowski, W, O'Donnell, MJ, Odyniec, A, Oh, K, Ohira, M, Okamoto, Y, Okpala, M, Okubo, S, Olah, L, Olavarria, V, Oleszek, J, Onat Demirci, N, Ondar, V, Ongun, G, Ooyama, K, Orosz, V, Ortiz, R, Osseby, G, Österlund-Tauriala, E, Ovesen, C, Ozcekic Demirhan, S, Ozdoba-Rot, J, Ozturk, S, Ozyurt, E, Pablo Grecco, M, Pablo Povedano, G, Paciaroni, M, Padiglioni, C, Pagola, J, Palasik, W, Panczel, G, Panos, L, Papadopoulos, G, Papadopoulou, E, Papagiannis, A, Papavasileiou, V, Papina, M, Pardo De Donlebun, JR, Parisi, V, Park, JM, Pasten, J, Patel, N, Pavlik, O, Pawelczyk, M, Peacock, WF, Pei, H, Peisker, T, Pena Sedna, LF, Penn, A, Pentek, S, Pepper, E, Pereira, L, Perera, K, Perez, Y, Perez, S, Perez Leguizamon, P, Pernicka, M, Perry, R, Persico, A, Pesant, Y, Peska, S, Peters, D, Peters, G, Pettigrew, L, Phan, T, Philippi, S, Phinney, T, Pico, F, Pidal, A, Piechowski-Jozwiak, B, Pieroni, A, Pineiro, S, Piras, V, Pizova, N, Polanco, J, Polin, M, Polyakov, A, Polychronopoulou, E, Polymeris, A, Popov, D, Poppe, A, Postorino, P, Pozzerese, C, Pradhan, M, Prats, L, Prazdnichkova, E, Prendl, B, Pretorius, M, Profice, P, Prokopenko, S, Pudov, E, Pujol Lereis, V, Punzo Bravo, G, Purroy, F, Qiu, J, Qu, X, Quenardelle, V, Quesada Garcia, H, Radrizzani, L, Radtke, A, Raffelsberger, T, Ramirez Moreno, JM, Ramos-Estebanez, C, Rani, A, Rapantova, P, Rashed, K, Rasheed Nihara, A, Rasmussen, J, Redondo Robles, L, Reif, M, Reiner, P, Rekova, P, Renu, A, Repetto, M, Reyes, P, Reyes Morales, S, Rha, JH, Ribeiro, J, Ricci, S, Richard, C, Rigual, R, Rinaldi, C, Riveira Rodriguez, C, Rizzato, B, Robinson, TG, Rocco, A, Rodrigues, M, Rodriguez, G, Rodriguez Campello, A, Rodriguez Lucci, F, Rodriguez Yanez, M, Roesler, C, Roffe, C, Roine, R, Roine, S, Roldan, A, Romana Pezzella, F, Romano, M, Roos, JS, Rosso, C, Rostrup Kruuse, C, Roth, Y, Roukens, R, Roveri, L, Rozanski, D, Rozniecki, J, Rozsa, C, Rudilosso, S, Ruiz Ares, G, Ruiz Franco, A, Rum, G, Ruuskanen, J, Rybinnik, I, Ryota, K, Saarinen, J, Saavedra, V, Sabben, C, Sabet, A, Sagris, D, Sahlas, J, Sakai, N, Salamanca, P, Salgado, P, Salig, S, Salletmayr, T, Salnikov, M, Samoshkina, O, Samson, Y, Sanak, D, Sànchez Cerón, M, Santalucia, P, Santamaria Cadavid, M, Santiago, P, Santo, G, Sanz Cuesta, B, Sargento, J, Sarraj, A, Sas, K, Sas, A, Satoshi, O, Satsoglou, S, Sattar, N, Savitz, S, Savopoulos, C, Saw, J, Sawicka, M, Sawyer, R, Scandura, T, Schillinger, N, Schindler, J, Schlachetzki, F, Schneider, I, Schuppner, R, Schurig, J, Schwarzbach, CJ, Sebejova, M, Seidel, G, Sekaran, L, Selcuk, D, Selvarajah, J, Semerano, A, Semjen, J, Semushina, D, Sen, S, Seok Park, M, Serena, J, Serhat Tokgoz, O, Serles, W, Serrano, F, Sevin, M, Seynaeve, L, Shah, S, Shamalov, N, Shang, T, Sharma, M, Sharrief, A, Shazam Hussain, M, Shchukin, I, Shen, W, Shepeleva, E, Shinsuke, I, Shmonin, A, Shoamanesh, A, Shuaib, A, Shulga, A, Sibolt, G, Sibon, I, Sicilia, I, Siebert, M, Sieczkowska, E, Sila, C, Silva, AA, Silva, D, Silva, P, Silva, Y, Silvestrini, M, Simony, Z, Simpkins, A, Singh, B, Sinha, D, Sipos, I, Skoda, O, Skowron, P, Skowronska, M, Sliwinska, B, Slonkova, J, Smolkin, A, Smyth, A, Sobolewski, P, Sobota, A, Sohn, SI, Soldatov, M, Solganov, I, Soloveva, L, Solovyeva, E, Sonntag, N, Soors, P, Sorgun, M, Soriano, C, Spence, D, Spengos, K, Sposato, L, Staaf, G, Stadler, K, Stakhovskaya, L, Stamatelopoulos, K, Steinert, S, Stetkarova, I, Stiehm, M, Stocker, R, Stoinski, J, Stoll, A, Stotts, G, Stumpp, A, Sucapane, P, Suenaga, T, Sun, X, Sundararajan, S, Sung Kim, J, Suzuki, H, Svaneborg, N, Szasz, G, Szczuchniak, W, Szczyrba, S, Szegedi, N, Szekely, A, Szewczyk, Z, Szilagyi, G, Szlufik, S, Szoboszlai, K, Szpisjak, L, Sztajzel, R, Sztriha, L, Ta Wil, SE, Taggeselle, J, Takamatsu, K, Takao, M, Taki, W, Takizawa, S, Talahma, M, Tamayo, A, Tan, J, Tanne, D, Tapanainen, A, Tapiola, T, Tarasiuk, J, Tatlisumak, T, Tayal, A, Tcvetkova, S, Teal, P, Tejada Garcia, J, Tejada Meza, H, Tenora, D, Terceno, M, Terentiou, A, Tezcan, S, Thaler, D, Thomson, A, Thouvenot, E, Tiainen, M, Timberg, I, Timsit, S, Tinchon, A, Tirschwell, D, Togay Isikay, C, Tokunaga, K, Tolino, M, Toloza, C, Tomelleri, G, Tomoyuki, K, Tomppo, LM, Tong, Z, Tong, L, Toni, D, Torres, J, Tossavainen, C, Toth, G, Tountopoulou, A, Touze, E, Tovar, M, Toyoda, K, Trillo, S, Trommer, A, Tropepi, D, Tryambake, D, Tu, H, Tuetuencue, S, Tumova, R, Tumpula, O, Turc, G, Tutaj, A, Tynkkynen, J, Uchiyama, S, Uchwat, U, Uhrinyakova, L, Ulku Acar, R, Uluduz Ugurlu, D, Urra, X, Urui, S, Usero Ruiz, M, Vaclavik, D, Vahedi, K, Valikovics, A, Valpas, J, Van Acker, P, Van Daele, W, Vanderschueren, G, Vanina Jure, L, Varela, R, Varga, Z, Varvat, J, Varvyanskaya, N, Vasco Salgado, A, Vasko, P, Vass, L, Vassilopoulou, S, Vastagh, I, Vazquez, P, Vecsei, L, Veltkamp, R, Venti, M, Verdugo, M, Verocai, V, Veronica Marroquin, M, Veronica Simonsini, C, Veverka, T, Vigl, M, Vila, A, Vilar, C, Villanueva Osorio, JA, Virta, J, Vitkova, E, Voglsperger, B, Volna, J, Von Weitzel-Mudersbach, PA, Vora, N, Voznyuk, I, Wach-Klink, A, Wacongne, A, Walters, D, Wang, Y, Wang, J, Wang, L, Wang, X, Wang, W, Wang, N, Wang, D, Wang, H, Warnack, W, Wartenberg, K, Waters, R, Waters, M, Webb, T, Weber, J, Weiss, G, Weissenborn, K, Weitz, JI, Weller, B, Wen, G, Weng, G, Werner, P, Werring, D, Wester, P, Whiteley, W, Whiting, R, Wijeratne, T, Willems, C, Wilson, L, Wilson, C, Winder, T, Windt, J, Winkler, A, Winska-Tereszkiewicz, A, Wisniewska, A, Wittayer, M, Wlodek, A, Wojnarowska-Arendt, A, Wolf, M, Wolff, V, Wolter, C, Wong, A, Wook Nah, H, Worthmann, H, Wu, W, Wu, S, Wunderlich, S, Wurzinger, H, Wyse, DG, Xiao, B, Xiaopeng, W, Ximenez-Carrillo, A, Xiong, L, Xiong, Y, Xiong, W, Xu, Y, Xu, J, Xu, Z, Yalo, B, Yamada, T, Yamasaki, M, Yang, L, Yang, Y, Yang, X, Yang, Q, Yang, B, Yang, J, Yasuhiro, I, Yee Lam, M, Yegappan, C, Yip, S, Ylikallio, E, Ylikotila, P, Yongwon Jin, A, Yoon, BW, Yoshida, Y, Yperzeele, L, Yuan, H, Yuasa, H, Zalewska, J, Zanferrari, C, Zapata, E, Zboznovits, D, Zelenka, I, Zhang, C, Zhang, B, Zhang, S, Zhang, M, Zhang, X, Zhang, J, Zhao, L, Zhirnova, O, Zhou, L, Zielinska-Turek, J, Zinchenko, I, Ziomek, M, Zitzmann, A, Zweifler, R, Zwiernik, J, Kasner, Scott E, Swaminathan, Balakumar, Lavados, Pablo, Sharma, Mukul, Muir, Keith, Veltkamp, Roland, Ameriso, Sebastian F, Endres, Matthias, Lutsep, Helmi, Messé, Steven R, Spence, J David, Nedeltechev, Krassen, Perera, Kanjana, Santo, Gustavo, Olavarria, Veronica, Lindgren, Arne, Bangdiwala, Shrikant, Shoamanesh, Ashkan, Berkowitz, Scott D, Mundl, Hardi, Connolly, Stuart J, and Hart, Robert G
Published: 2018
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2. EFEITOS PROGNÓSTICOS DA UTILIZAÇÃO DOS INIBIDORES DA TIROSINA QUINASE NO TRATAMENTO DA LEUCEMIA MIELOIDE CRÔNICA: UMA REVISÃO SISTEMÁTICA

Author: Silva, AA, primary, Barreto, JC, additional, Wanderley, MCA, additional, and Albertim, GJB, additional
Published: 2023
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3. Analysis of motor performance in individuals with cerebral palsy using a non-immersive virtual reality task – a pilot study

Author: Martins FPA, Massetti T, Crocetta TB, Bianchi Lopes P, da Silva AA, Figueiredo EF, de Abreu LC, da Silva TD, and Monteiro CBM
Subjects: Cerebral Palsy, Motor Performance, Virtual Reality, Motor Disability, Spastic Cerebral Palsy., Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract: Fabiana Paula Almeida Martins,1,2 Thaís Massetti,3 Tania Brusque Crocetta,1 Priscila Bianchi Lopes,4 Amanda Abreu da Silva,2 Eliketylen Fernandes Figueiredo,2 Luiz Carlos de Abreu,1 Talita Dias da Silva,5 Carlos Bandeira de Mello Monteiro3 1Study Design and Scientific Writing Laboratory, ABC Medical School (FMABC), Santo André, São Paulo, Brazil; 2Research Laboratory, Northern Union of Education (UniNorte), Barão do Rio Branco Faculty, Rio Branco, Acre, Brazil; 3Postgraduate Program in Rehabilitation Sciences, Faculty of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil; 4Federal University of São Paulo, São Paulo, São Paulo, Brazil; 5Department of Medicine, School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, São Paulo, Brazil Purpose: To evaluate the performance improvement of individuals with hemiparesis cerebral palsy (CP) using a virtual task. Participants and methods: Twenty individuals were selected and distributed into two groups. The experimental group (CP group) comprised ten individuals with a medical diagnosis of CP, and ten individuals with typical development (sex- and age-matched) composed the control group (TD group). Both groups followed the same intervention protocol, which included a virtual coincident timing task: the participants performed upper limb movements in front of a computer’s webcam and interacted with the task with the aim of virtually intercepting spheres that fell in four rows following the rhythm of a pre-selected song during an 8-minute period. To verify the influence on a real task, pre- and posttests were performed in a similar task, but with physical contact (using the spacebar on the keyboard of a computer). To analyze the data, we evaluated the variable, constant, and absolute errors during the task and in the pre- and posttests. Results: The results showed that there was an improvement in performance between the pre- and posttests; that is, after practicing the task in an environment without physical contact, there was a performance improvement in posttests in the real task, but only for the CP group. Moreover, there were significant differences in precision and accuracy between the two groups, with worse performance in the CP group. Conclusion: Individuals with CP presented better performance in the real task after practice in a virtual reality task, albeit with worse performance compared with individuals with TD. This is an interesting result that supports the possible use of virtual tasks for the rehabilitation of individuals with CP. Keywords: cerebral palsy, motor performance, virtual reality, motor disability, spastic cerebral palsy
Published: 2019

4. FINANCIAL IMPACT OF IMATINIB DISCONTINUATION IN BRAZIL – A PHARMACOECONOMIC STUDY IN CHRONIC MYELOID LEUKEMIA OF A PRIVATE INSTITUTION

Author: Centrone, RT, primary, Bellesso, M, additional, Santucci, R, additional, Ferreira, JBMR, additional, Travassos, LC, additional, Espadas, C, additional, Gomes, T, additional, Rodrigues, MC, additional, and Silva, AA, additional
Published: 2022
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5. Impact of Pre-transport Feed Withdrawal on Welfare and Meat Characteristics of European Quails

Author: Silva,AA, Silva,FV, Maciel,MP, Ferreira,F, Oliveira,LLS, Silva Jr,AA, Aspiazú,I, and Oliveira,PHA
Subjects: preslaughter, meat-type quail, restricted feeding, Fasting, hunger
Abstract: The objective of this study was evaluate whether pretransport feed withdrawal affects welfare, carcass, and meat characteristics of European quails. A total of 120 European quails were used, with an initial age of 15 days. Bird feed was removed before transport to the slaughterhouse at the following times, which characterised the different treatments: zero hours, three hours, six hours, nine hours and twelve hours. The transport took 54 minutes to cover 27 kilometres to a commercial slaughterhouse. The birds were slaughtered at 41 days of age. During bleeding, blood samples were collected. Blood glucose, total protein, albumin, uric acid, and corticosterone concentrations were measured. The carcasses and meat characteristics were measured. Poultry body weight decreased and blood glucose concentrations increased with the increase in feed withdrawal time. The treatments did not affect carcass weights. Carcass yields after three hours fasting were similar to those in the six hours and nine hours groups, indicating that gastrointestinal tracts were empty after the third hour. Meat quality was negatively affected (pH, lightness, water holding capacity, cooking loss) by the increase in feed withdrawal time; integrated parameters that characterise dark, firm, dry meat. Pre transport feed withdrawal time should be three hours to empty the gastrointestinal tract and minimise losses in meat quality of European quails. It is necessary to adjust feed withdrawal so that it does not exceed this time, since there is no technical justification for supporting it.
Published: 2022

6. Obesity, hypertension, and chronic kidney disease

Author: Hall ME, do Carmo JM, da Silva AA, Juncos LA, Wang Z, and Hall JE
Subjects: Diseases of the genitourinary system. Urology, RC870-923
Abstract: Michael E Hall,1,2 Jussara M do Carmo,2 Alexandre A da Silva,2 Luis A Juncos,1,2 Zhen Wang,2 John E Hall2 1Department of Medicine, 2Department of Physiology and Biophysics, Mississippi Center for Obesity Research, University of Mississippi Medical Center, Jackson, MS, USA Abstract: Obesity is a major risk factor for essential hypertension, diabetes, and other comorbid conditions that contribute to development of chronic kidney disease. Obesity raises blood pressure by increasing renal tubular sodium reabsorption, impairing pressure natriuresis, and causing volume expansion via activation of the sympathetic nervous system and renin-angiotensin-aldosterone system and by physical compression of the kidneys, especially when there is increased visceral adiposity. Other factors such as inflammation, oxidative stress, and lipotoxicity may also contribute to obesity-mediated hypertension and renal dysfunction. Initially, obesity causes renal vasodilation and glomerular hyperfiltration, which act as compensatory mechanisms to maintain sodium balance despite increased tubular reabsorption. However, these compensations, along with increased arterial pressure and metabolic abnormalities, may ultimately lead to glomerular injury and initiate a slowly developing vicious cycle that exacerbates hypertension and worsens renal injury. Body weight reduction, via caloric restriction and increased physical activity, is an important first step for management of obesity, hypertension, and chronic kidney disease. However, this strategy may not be effective in producing long-term weight loss or in preventing cardiorenal and metabolic consequences in many obese patients. The majority of obese patients require medical therapy for obesity-associated hypertension, metabolic disorders, and renal disease, and morbidly obese patients may require surgical interventions to produce sustained weight loss. Keywords: visceral adiposity, type II diabetes, sodium reabsorption, glomerular filtration rate, sympathetic nervous system, renin-angiotensin-aldosterone system
Published: 2014

7. Impact of Pre-transport Feed Withdrawal on Welfare and Meat Characteristics of European Quails

Author: Silva, AA, primary, Silva, FV, additional, Maciel, MP, additional, Ferreira, F, additional, Oliveira, LLS, additional, Silva Jr, AA, additional, Aspiazú, I, additional, and Oliveira, PHA, additional
Published: 2022
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8. RESOLUÇÃO DE PROBLEMAS SOROLOGICOS DEVIDO A PRESENÇA DE AUTO-ANTICORPO FRIO × TRANSFUSÃO

Author: Valvasori, M, primary, Oliveira, AS, additional, Silva, AA, additional, Junior, ESB, additional, Araújo, EP, additional, Gonzaga, FDN, additional, Rosa, LFS, additional, Piovesan, PLS, additional, Moraes, RS, additional, and Nascimento, WDAD, additional
Published: 2021
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9. Land-Use Effect on Olive Groves Pest Prays oleae and on Its Potential Biocontrol Agent Chrysoperla carnea

Author: Alves JF, Mendes S, Silva AA, Sousa JP, and Paredes D
Abstract: To rethink the counterproductive effects of the recurrent use of pesticides to control pests, we examine how a conservation biological control approach can promote the necessary conditions for the development of a natural enemy (Chrysoperla carnea) that controls olive moth pest (Prays oleae) in 25 olive groves of the Portuguese Beira Interior region. Our study has the distinctive peculiarity of joining varied technical approaches, since the databases contained information related to the abundance records of both insect populations, the record of olive fruits infestation by the pest, and the information obtained after a geospatial analysis that resulted in landscape metrics. Overall, we corroborated the attraction of C. carnea to the olive moth, highlighted the possible biocontrol potential of C. carnea on this pest, asserted that the promotion of the diversity of land-uses has a significant effect in reducing the abundance of pest, and confirmed that landscapes dominated by olive groves promote the development of P. oleae. The implication of these results is of extreme importance for olive growers since promoting land-uses complexity and heterogeneity surrounding olive groves can reduce the likelihood of suffering pest outbreaks and help to avoid associated economic and environmental problems.
Published: 2021

10. Do age and time of practice predict the development of life skills among youth futsal practitioners?

Author: Freire,GLM, Silva,AA, Moraes,JFVN, Costa,NLG, Oliveira,DV, and Nascimento Junior,JRA
Subjects: Adolescentes Deporte, Positive Youth Development, Desarrollo Juvenil Positivo, Esporte, Desenvolvimento Positivo de Jovens, Adolescents, Adolescentes, Sport
Abstract: (150 words) (same order that title) The practice of sports has been considered one of the main tools for the life skills development among youth sport participants. This cross-sectional study investigated the predicting role of age and time of practice in the development of life skills among 207 male youth futsal practitioners from the state of Pernambuco, Brazil. The instruments used were the Life Skills Scale for Sports and a semi-structured questionnaire. Data analysis was conducted through Multivariate Analysis of Variance, Pearson's correlation and Multiple Regression (p
Published: 2021

11. Survey of Fertility Preservation Options Available to Patients With Cancer Around the Globe

Author: Rashedi, AS, de Roo, SF, Ataman, LM, Edmonds, ME, Silva, AA, Scarella, A, Horbaczewska, A, Anazodo, A, Arvas, A, de Carvalho, BR, Sartorio, C, Beerendonk, CCM, Diaz-Garcia, C, Suh, CS, Melo, C, Andersen, CY, Motta, E, Greenblatt, EM, Van Moer, E, Zand, E, Reis, FM, Sanchez, F, Terrado, G, Rodrigues, JK, de Meneses e Silva, JM, Smitz, J, Medrano, J, Lee, JR, Winkler-Crepaz, K, Smith, K, Ferreira Melo e Silva, LH, Wildt, L, Salama, M, del Mar Andres, M, Bourlon, MT, Vega, M, Chehin, MB, De Vos, M, Khrouf, M, Suzuki, N, Azmy, O, Fontoura, P, Almeida Campos-Junior, PH, Mallmann, P, Azambuja, R, Marinho, RM, Anderson, RA, Jach, R, Antunes, RDA, Mitchell, R, Fathi, R, Adiga, SK, Takae, S, Kim, SH, Romero, S, Grieco, SC, Shaulov, T, Furui, T, Almeida-Santos, T, Nelen, W, Jayasinghe, Y, Sugishita, Y, Woodruff, TK, Rashedi, AS, de Roo, SF, Ataman, LM, Edmonds, ME, Silva, AA, Scarella, A, Horbaczewska, A, Anazodo, A, Arvas, A, de Carvalho, BR, Sartorio, C, Beerendonk, CCM, Diaz-Garcia, C, Suh, CS, Melo, C, Andersen, CY, Motta, E, Greenblatt, EM, Van Moer, E, Zand, E, Reis, FM, Sanchez, F, Terrado, G, Rodrigues, JK, de Meneses e Silva, JM, Smitz, J, Medrano, J, Lee, JR, Winkler-Crepaz, K, Smith, K, Ferreira Melo e Silva, LH, Wildt, L, Salama, M, del Mar Andres, M, Bourlon, MT, Vega, M, Chehin, MB, De Vos, M, Khrouf, M, Suzuki, N, Azmy, O, Fontoura, P, Almeida Campos-Junior, PH, Mallmann, P, Azambuja, R, Marinho, RM, Anderson, RA, Jach, R, Antunes, RDA, Mitchell, R, Fathi, R, Adiga, SK, Takae, S, Kim, SH, Romero, S, Grieco, SC, Shaulov, T, Furui, T, Almeida-Santos, T, Nelen, W, Jayasinghe, Y, Sugishita, Y, and Woodruff, TK
Abstract: PURPOSE: In the accompanying article, "Analysis of Fertility Preservation Options Available to Patients With Cancer Around the Globe," we showed that specific fertility preservation services may not be offered at various sites around the world because of cultural and legal barriers. We assessed global and regional experiences as well as the legal status of third-party reproduction and adoption to serve as a comprehensive international data set and resource for groups that wish to begin oncofertility interventions. METHODS: We provide data on the legalities of third-party assisted reproductive technologies and other family-building options in the 28 oncofertility-practicing countries surveyed. RESULTS: We found regional and country differences that will be important in the development of tailored resources for physicians and for patient brochures that are sensitive to these local restrictions and cultural norms. CONCLUSION: Because many patients first consult Web-based materials, the formal assessment of the availability of these options provides members of the global oncofertility community with data to which they might otherwise not have ready access to better serve their patients.
Published: 2020

12. Biopolymer Extracted from Anadenanthera colubrina (Red Angico Gum) Exerts Therapeutic Potential in Mice: Antidiarrheal Activity and Safety Assessment

Author: Araujo, TSL, de Oliveira, TM, de Sousa, NA, Souza, LKM, Sousa, FBM, de Oliveira, AP, Nicolau, LAD, Silva, AA, Araujo, AR, Magalhaes, PJC, Vasconcelos, DFP, de Jonge, Hugo, Souza, M, Silva, DAS, Paula, RCM, Medeiros, JVR, Araujo, TSL, de Oliveira, TM, de Sousa, NA, Souza, LKM, Sousa, FBM, de Oliveira, AP, Nicolau, LAD, Silva, AA, Araujo, AR, Magalhaes, PJC, Vasconcelos, DFP, de Jonge, Hugo, Souza, M, Silva, DAS, Paula, RCM, and Medeiros, JVR
Published: 2020

13. Acute Cerebrovascular Disease in the Young: The Stroke in Young Fabry Patients Study

Author: Rolfs, Arndt, Fazekas, Franz, Grittner, Ulrike, Dichgans, Martin, Martus, Peter, Holzhausen, Martin, Böttcher, Tobias, Heuschmann, Peter U., Tatlisumak, Turgut, Tanislav, Christian, Jungehulsing, Gerhard J., Giese, Anne-Katrin, Putaala, Jukaa, Huber, Roman, Bodechtel, Ulf, Lichy, Christoph, Enzinger, Christian, Schmidt, Reinhold, Hennerici, Michael G., Kaps, Manfred, Kessler, Christof, Lackner, Karl, Paschke, Eduard, Meyer, Wolfgang, Mascher, Hermann, Riess, Olaf, Kolodny, Edwin, Norrving, Bo, Rolfs, A, Ginsberg, M, Hennerici, MG, Kessler, C, Kolodny, E, Martus, P, Norrving, B, Ringelstein, EB, Rothwell, PM, Venables, G, Bornstein, N, deDeyn, P, Dichgans, M, Fazekas, F, Markus, H, Rie, O, Biedermann, C, Böttcher, T, Brüderlein, K, Burmeister, J, Federow, I, König, F, Makowei, G, Niemann, D, Rolfs, A, Rösner, S, Zielke, S, Grittner, U, Martus, P, Holzhausen, M, Fazekas, F, Enzinger, C, Schmidt, R, Ropele, S, Windisch, M, Sterner, E, Bodamer, O, Fellgiebel, A, Hillen, U, Jonas, L, Kampmann, C, Kropp, P, Lackner, K, Laue, M, Mascher, H, Meyer, W, Paschke, E, Weidemann, F, Berrouschot, J, Stoll, A, Rokicha, A, Sternitzky, C, Thomä, M, DeDeyn, PP, Sheorajpanday, R, De Brabander, I, Yperzeele, L, Brouns, R, Oschmann, P, Pott, M, Schultes, K, Schultze, C, Hirsekorn, J, Jungehulsing, GJ, Villringer, A, Schmidt, W, Liman, T, Nowe, T, Ebinger, M, Wille, A, Loui, H, Objartel, A, übelacker, A, Mette, R, Jegzentis, K, Nabavi, DG, Crome, O, Bahr, D, Ebke, M, Platte, B, Kleinen, C, Mermolja Gunther, K, Heide, W, Pape, O, Hanssen, JR, Stangenberg, D, Klingelhofer, J, Schmidt, B, Schwarz, S, Schwarze, J, Frandlih, L, Iwanow, J, Steinbach, I, Krieger, D, Boysen, G, Leth Jeppesen, L, Petersen, A, Reichmann, H, Becker, U, Dzialkowski, I, Hentschel, H, Lautenschlager, C, Hanso, H, Gahn, G, Ziemssen, T, Fleischer, K, Sehr, B, McCabe, DJH, Tobin, O, Kinsella, J, Murphy, RP, Jander, S, Hartung, HP, Siebler, M, Bottcher, C, Kohne, A, Platzen, J, Brosig, TC, Rothhammer, V, Henseler, C, Neumann-Haefelin, T, Singer, OC, Ermis, U, dos Santos, IMRM, Schuhmann, C, van de Loo, S, Kaps, M, Allendorfer, J, Tanislav, C, Brandtner, M, Muir, K, Dani, K, MacDougall, N, Smith, W, Rowe, A, Welch, A, Fazekas, F, Schrotter, G, Krenn, U, Horner, S, Pendl, B, Pluta-Fuerst, A, Trummer, U, Kessler, C, Chatzopoulos, M, v Sarnowski, Bettina, Schminke, Ulf, Link, T, Khaw, A, Nieber, E, Zierz, S, Muller, T, Wegener, N, Wartenberg, K, Gaul, C, Richter, D, Rosenkranz, M, Krützelmann, AC, Hoppe, J, Choe, CU, Narr, S, Magnus, TU, Thomalla, G, Leypoldt, F, Otto, D, Lichy, C, Hacke, W, Barrows, RJ, Tatlisumak, T, Putaala, J, Curtze, S, Metso, M, Willeit, J, Furtner, M, Spiegel, M, Knoflach, MH, Prantl, B, Witte, OW, Brämer, D, Günther, A, Prell, T, Herzau, C, Aurich, K, Deuschl, G, Wodarg, F, Zimmermann, P, Eschenfelder, CC, Levsen, M, Weber, JR, Marecek, SM, Schneider, D, Michalski, D, Kloppig, W, Küppers-Tiedt, L, Schneider, M, Schulz, A, Matzen, P, Weise, C, Hobohm, C, Meier, H, Langos, R, Urban, D, Gerhardt, I, Thijs, V, Lemmens, R, Marcelis, E, Hulsbosch, C, Aichner, F, Haring, HP, Bach, E, Machado Candido, J, e Silva, AA, Lourenco, M, de Sousa, AIM, Derex, L, Cho, TH, Díez-Tejedor, E, Fuentes, B, Martínez-Sanchez, P, Pérez-Guevara, MI, Hamer, H, Metz, A, Hallenberger, K, Müller, P, Baron, P, Bersano, A, Gattinoni, M, Vella, N, Mallia, M, Jauss, M, Adam, L, Heidler, F, Gube, C, Kiszka, M, Dichgans, M, Karpinska, A, Mewald, Y, Straub, V, Dörr, A, Zollver, A, Ringelstein, EB, Schilling, M, Borchert, A, Preuth, N, Duning, T, Kuhlenbäumer, G, Schulte, D, Rothwell, PM, Marquardt, L, Schlachetzki, F, Boy, S, Mädl, J, Ertl, GM, Fehm, NPR, Stadler, C, Benecke, R, Dudesek, A, Kolbaske, S, Lardurner, G, Sulzer, C, Zerbs, A, Lilek, S, Walleczek, AM, Sinadinowska, D, Janelidze, M, Beridze, M, Lobjanidze, N, Dzagnidze, A, Melms, A, Horber, K, Fink, I, Liske, B, Ludolph, AC, Huber, R, Knauer, K, Hendrich, C, Raubold, S, Czlonkowska, A, Baranowska, A, Blazejewska-Hyzorek, B, Lang, W, Kristoferitsch, W, Ferrari, J, Ulrich, E, Flamm-Horak, A, Lischka-Lindner, A, Schreiber, W, Demarin, V, Tranjec, Z, Bosner-Puretic, M, Jurašić, MJ, Basic Kes, V, Budisic, M, and Kopacevic, L
Published: 2013
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14. Consequences of ignoring patient diagnoses when using the 2015 Updated Beers Criteria

Author: Lavrador, M, Silva, AA, Cabral, AC, Caramona, MM, Fernandez-Llimos, F, Figueiredo, IV, Castel-Branco, MM, Lavrador, M, Silva, AA, Cabral, AC, Caramona, MM, Fernandez-Llimos, F, Figueiredo, IV, and Castel-Branco, MM
Abstract: © 2019, Springer Nature Switzerland AG. Background: Beers Criteria are one of the best known explicit criteria to identify inappropriate medication in elderly that can be used in medication review. The access to patients’ medical records may be different among healthcare professionals and settings and, subsequently, the identification of patients’ diagnoses may be compromised. Objective: To assess the consequences of ignoring patient diagnoses when applying 2015 Beers Criteria to identify potentially inappropriate medication (PIM). Setting: Three nursing homes in Central Portugal. Method: Medical records of nursing home residents over 65 years old were appraised to identify medication profile and medical conditions. 2015 Beers Criteria were used with and without considering patients’ diagnoses. To compare the number of PIM and PIM-qualifying criteria complied in these two judgements, Wilcoxon signed-rank tests were performed. Main outcome measure: Number of PIMs and number of PIM-qualifying criteria. Results: A total of 185 patients with a mean age of 86.7 years (SD = 7.8) with a majority of female (70.3%) were studied. When assessing the patients with full access to the diagnoses, median number of PIMs was 4 (IQR 0–10) and number of PIM-qualifying criteria was 5 (IQR 0–15). When evaluating only patient current medication, median number of PIMs was 4 (IQR 0–10) and PIM-qualifying criteria was 4 (IQR 0–12). Statistical difference was found in the number of PIM-qualifying criteria identified (p < 0.001), but not in the number of PIMs per patient (p = 0.090). In 171 patients (92.4%) PIMs identified were identical when using or ignoring their medical diagnoses. However, in 80 patients (43.2%) the PIM-qualifying criteria complied were different with and without access to patient diagnoses. Conclusion: Although restricted access to patients’ diagnoses may limit the judgement of Beers PIM-qualifying criteria, this limitation had no effect on the number of PIM identified.
Published: 2019

15. Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial

Author: Kasner, Scott E, primary, Swaminathan, Balakumar, additional, Lavados, Pablo, additional, Sharma, Mukul, additional, Muir, Keith, additional, Veltkamp, Roland, additional, Ameriso, Sebastian F, additional, Endres, Matthias, additional, Lutsep, Helmi, additional, Messé, Steven R, additional, Spence, J David, additional, Nedeltechev, Krassen, additional, Perera, Kanjana, additional, Santo, Gustavo, additional, Olavarria, Veronica, additional, Lindgren, Arne, additional, Bangdiwala, Shrikant, additional, Shoamanesh, Ashkan, additional, Berkowitz, Scott D, additional, Mundl, Hardi, additional, Connolly, Stuart J, additional, Hart, Robert G, additional, Abdelhamid, N, additional, Abdul Rahman, D, additional, Abdul-Saheb, M, additional, Abreu, P, additional, Abroskina, M, additional, Abu Ahmad, F, additional, Accassat, S, additional, Acciaresi, M, additional, Adami, A, additional, Ahmad, N, additional, Ahmed, F, additional, Alberto Hawkes, M, additional, Alemseged, F, additional, Ali, A, additional, Altavilla, R, additional, Alwis, L, additional, Amarenco, P, additional, Amaro, S, additional, Amaya Sanchez, LE, additional, Amelia Pinto, A, additional, Ameriso, SF, additional, Amin, H, additional, Amino, T, additional, Amjad, AK, additional, Anagnostou, E, additional, Andersen, G, additional, Anderson, C, additional, Anderson, DC, additional, Andrea Falco, M, additional, Andres Mackinnon, F, additional, Andreu, D, additional, Androulakis, M, additional, Angel Gamero, M, additional, Angel Saredo, G, additional, Angeles Diaz, R, additional, Angels Font, M, additional, Anticoli, S, additional, Arauz, A, additional, Arauz Gongora, AA, additional, Araya, P, additional, Arenillas Lara, JF, additional, Arias Rivas, S, additional, Arnold, M, additional, Augustin, S, additional, Avelar, W, additional, Azevedo, E, additional, Babikian, V, additional, Bacellar, A, additional, Badalyan, K, additional, Bae, HJ, additional, Baez Martinez, EM, additional, Bagelmann, H, additional, Bailey, P, additional, Bak, Z, additional, Baker, M, additional, Balazs, A, additional, Baldaranov, D, additional, Balogun, I, additional, Balueva, T, additional, Bankuti, Z, additional, Bar, M, additional, Baranowska, A, additional, Bardutzky, J, additional, Barker Trejo, S, additional, Barlinn, J, additional, Baronnet, F, additional, Barroso, C, additional, Barteys, M, additional, Bartolottiova, T, additional, Barulin, A, additional, Bas, M, additional, Bashir, S, additional, Basile, V, additional, Bathe-Peters, R, additional, Bathula, R, additional, Batista, C, additional, Batur Caglayan, H, additional, Baumgartner, P, additional, Bazan, R, additional, Bazhenova, O, additional, Beaudry, M, additional, Beer, J, additional, Behnam, Y, additional, Beilei, C, additional, Beinlich, A, additional, Bejot, Y, additional, Belkin, A, additional, Benavente, OR, additional, Benjamin, A, additional, Berardi, V, additional, Bereczki, D, additional, Berkowitz, SD, additional, Berlingieri, J, additional, Berrios, W, additional, Berrouschot, J, additional, Bhandari, M, additional, Bhargavah, M, additional, Bicker, H, additional, Bicsak, T, additional, Bilik, M, additional, Bindila, D, additional, Birchenall, J, additional, Birnbaum, L, additional, Black, T, additional, Blacker, D, additional, Blacquiere, D, additional, Blanc-Labarre, C, additional, Blank, C, additional, Blazejewska-Hyzorek, B, additional, Bloch, S, additional, Bodiguel, E, additional, Bogdanov, E, additional, Boos, L, additional, Borcsik, L, additional, Bornstein, N, additional, Bouly, S, additional, Braga, G, additional, Bragado, I, additional, Bravi, MC, additional, Brokalaki, C, additional, Brola, W, additional, Brouns, R, additional, Bruce, D, additional, Brzoska-Mizgalska, J, additional, Buck, B, additional, Buksinska-Lisik, M, additional, Burke, J, additional, Burn, M, additional, Bustamante, G, additional, Cabrejo, L, additional, Cai, K, additional, Cajaraville, S, additional, Calejo, M, additional, Calvet, D, additional, Campillo, J, additional, Campos Costa, E, additional, Camps, P, additional, Can Alaydin, H, additional, Candeloro, E, additional, Canepa, C, additional, Cantu Brito, CG, additional, Cappellari, M, additional, Carcel, C, additional, Cardona Portela, P, additional, Cardoso, F, additional, Carek, M, additional, Carletti, M, additional, Carlos Portilla, J, additional, Caruso, P, additional, Casado-Naranjo, I, additional, Castellini, P, additional, Castro, D, additional, Castro Meira, F, additional, Cavallini, A, additional, Cayuela Caudevilla, N, additional, Cenciarelli, S, additional, Cereda, C, additional, Cerrone, P, additional, Chakrabarti, A, additional, Chaloulos-Iakovidis, P, additional, Chamorro, A, additional, Chandrasena, D, additional, Chang, DI, additional, Che, C, additional, Chembala, J, additional, Chen, J, additional, Chen, Z, additional, Chen, T, additional, Chen, H, additional, Chen, X, additional, Chen, G, additional, Chen, L, additional, Chen, S, additional, Cheripelli, B, additional, Chin, M, additional, Chiquete Anaya, E, additional, Chorazy, M, additional, Christensen, H, additional, Christensen, T, additional, Christian, L, additional, Chu, F, additional, Chung, CS, additional, Clark, W, additional, Clarke, R, additional, Claverie, S, additional, Clemente Agostoni, E, additional, Clissold, B, additional, Coelho, J, additional, Cohen, D, additional, Colakoglu, S, additional, Collas, D, additional, Condurso, R, additional, Connolly, SJ, additional, Consoli, D, additional, Constantin, C, additional, Constantino Silva, AB, additional, Contardo, L, additional, Corlobe, A, additional, Correia, M, additional, Correia, C, additional, Cortijo Garcia, E, additional, Coull, B, additional, Coutts, S, additional, Coveney, S, additional, Cras, P, additional, Crols, R, additional, Crozier, S, additional, Csanyi, A, additional, Csiba, L, additional, Csontos, K, additional, Csuha, R, additional, Cui, L, additional, 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additional, Stotts, G, additional, Stumpp, A, additional, Sucapane, P, additional, Suenaga, T, additional, Sun, X, additional, Sundararajan, S, additional, Sung Kim, J, additional, Suzuki, H, additional, Svaneborg, N, additional, Szasz, G, additional, Szczuchniak, W, additional, Szczyrba, S, additional, Szegedi, N, additional, Szekely, A, additional, Szewczyk, Z, additional, Szilagyi, G, additional, Szlufik, S, additional, Szoboszlai, K, additional, Szpisjak, L, additional, Sztajzel, R, additional, Sztriha, L, additional, Ta Wil, SE, additional, Taggeselle, J, additional, Takamatsu, K, additional, Takao, M, additional, Taki, W, additional, Takizawa, S, additional, Talahma, M, additional, Tamayo, A, additional, Tan, J, additional, Tanne, D, additional, Tapanainen, A, additional, Tapiola, T, additional, Tarasiuk, J, additional, Tatlisumak, T, additional, Tayal, A, additional, Tcvetkova, S, additional, Teal, P, additional, Tejada Garcia, J, additional, Tejada Meza, H, additional, Tenora, D, additional, Terceno, M, additional, Terentiou, A, additional, Tezcan, S, additional, Thaler, D, additional, Thomson, A, additional, Thouvenot, E, additional, Tiainen, M, additional, Timberg, I, additional, Timsit, S, additional, Tinchon, A, additional, Tirschwell, D, additional, Togay Isikay, C, additional, Tokunaga, K, additional, Tolino, M, additional, Toloza, C, additional, Tomelleri, G, additional, Tomoyuki, K, additional, Tomppo, LM, additional, Tong, Z, additional, Tong, L, additional, Toni, D, additional, Torres, J, additional, Tossavainen, C, additional, Toth, G, additional, Tountopoulou, A, additional, Touze, E, additional, Tovar, M, additional, Toyoda, K, additional, Trillo, S, additional, Trommer, A, additional, Tropepi, D, additional, Tryambake, D, additional, Tu, H, additional, Tuetuencue, S, additional, Tumova, R, additional, Tumpula, O, additional, Turc, G, additional, Tutaj, A, additional, Tynkkynen, J, additional, Uchiyama, S, additional, Uchwat, U, additional, Uhrinyakova, L, additional, Ulku Acar, R, additional, Uluduz Ugurlu, D, additional, Urra, X, additional, Urui, S, additional, Usero Ruiz, M, additional, Vaclavik, D, additional, Vahedi, K, additional, Valikovics, A, additional, Valpas, J, additional, Van Acker, P, additional, Van Daele, W, additional, Vanderschueren, G, additional, Vanina Jure, L, additional, Varela, R, additional, Varga, Z, additional, Varvat, J, additional, Varvyanskaya, N, additional, Vasco Salgado, A, additional, Vasko, P, additional, Vass, L, additional, Vassilopoulou, S, additional, Vastagh, I, additional, Vazquez, P, additional, Vecsei, L, additional, Veltkamp, R, additional, Venti, M, additional, Verdugo, M, additional, Verocai, V, additional, Veronica Marroquin, M, additional, Veronica Simonsini, C, additional, Veverka, T, additional, Vigl, M, additional, Vila, A, additional, Vilar, C, additional, Villanueva Osorio, JA, additional, Virta, J, additional, Vitkova, E, additional, Voglsperger, B, additional, Volna, J, additional, Von Weitzel-Mudersbach, PA, additional, Vora, N, additional, Voznyuk, I, additional, Wach-Klink, A, additional, Wacongne, A, additional, Walters, D, additional, Wang, Y, additional, Wang, J, additional, Wang, L, additional, Wang, X, additional, Wang, W, additional, Wang, N, additional, Wang, D, additional, Wang, H, additional, Warnack, W, additional, Wartenberg, K, additional, Waters, R, additional, Waters, M, additional, Webb, T, additional, Weber, J, additional, Weiss, G, additional, Weissenborn, K, additional, Weitz, JI, additional, Weller, B, additional, Wen, G, additional, Weng, G, additional, Werner, P, additional, Werring, D, additional, Wester, P, additional, Whiteley, W, additional, Whiting, R, additional, Wijeratne, T, additional, Willems, C, additional, Wilson, L, additional, Wilson, C, additional, Winder, T, additional, Windt, J, additional, Winkler, A, additional, Winska-Tereszkiewicz, A, additional, Wisniewska, A, additional, Wittayer, M, additional, Wlodek, A, additional, Wojnarowska-Arendt, A, additional, Wolf, M, additional, Wolff, V, additional, Wolter, C, additional, Wong, A, additional, Wook Nah, H, additional, Worthmann, H, additional, Wu, W, additional, Wu, S, additional, Wunderlich, S, additional, Wurzinger, H, additional, Wyse, DG, additional, Xiao, B, additional, Xiaopeng, W, additional, Ximenez-Carrillo, A, additional, Xiong, L, additional, Xiong, Y, additional, Xiong, W, additional, Xu, Y, additional, Xu, J, additional, Xu, Z, additional, Yalo, B, additional, Yamada, T, additional, Yamasaki, M, additional, Yang, L, additional, Yang, Y, additional, Yang, X, additional, Yang, Q, additional, Yang, B, additional, Yang, J, additional, Yasuhiro, I, additional, Yee Lam, M, additional, Yegappan, C, additional, Yip, S, additional, Ylikallio, E, additional, Ylikotila, P, additional, Yongwon Jin, A, additional, Yoon, BW, additional, Yoshida, Y, additional, Yperzeele, L, additional, Yuan, H, additional, Yuasa, H, additional, Zalewska, J, additional, Zanferrari, C, additional, Zapata, E, additional, Zboznovits, D, additional, Zelenka, I, additional, Zhang, C, additional, Zhang, B, additional, Zhang, S, additional, Zhang, M, additional, Zhang, X, additional, Zhang, J, additional, Zhao, L, additional, Zhirnova, O, additional, Zhou, L, additional, Zielinska-Turek, J, additional, Zinchenko, I, additional, Ziomek, M, additional, Zitzmann, A, additional, Zweifler, R, additional, and Zwiernik, J, additional
Published: 2018
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16. Survey of fertility preservation options available to patients with cancer around the globe

Author: Rashedi, AS, De Roo, SF, Ataman, LM, Edmonds, ME, Silva, AA, Scarella, A, Horbaczewska, A, Anazodo, A, Arvas, A, De Carvalho, BR, Sartorio, C, Beerendonk, CCM, Diaz-Garcia, C, Suh, CS, Melo, C, Andersen, CY, Motta, E, Greenblatt, EM, Van Moer, E, Zand, E, Reis, FM, Sánchez, F, Terrado, G, Rodrigues, JK, De Meneses e Silva, JM, Smitz, J, Medrano, J, Lee, JR, Winkler-Crepaz, K, Smith, K, Melo e Silva, LHF, Wildt, L, Salama, M, Del Mar Andrés, M, Bourlon, MT, Vega, M, Chehin, MB, De Vos, M, Khrouf, M, Suzuki, N, Azmy, O, Fontoura, P, Campos-Junior, PHA, Mallmann, P, Azambuja, R, Marinho, RM, Anderson, RA, Jach, R, Antunes, RA, Mitchell, R, Fathi, R, Adiga, SK, Takae, S, Kim, SH, Romero, S, Grieco, SC, Shaulov, T, Furui, T, Almeida-Santos, T, Nelen, W, Jayasinghe, Y, Sugishita, Y, Woodruff, TK, Rashedi, AS, De Roo, SF, Ataman, LM, Edmonds, ME, Silva, AA, Scarella, A, Horbaczewska, A, Anazodo, A, Arvas, A, De Carvalho, BR, Sartorio, C, Beerendonk, CCM, Diaz-Garcia, C, Suh, CS, Melo, C, Andersen, CY, Motta, E, Greenblatt, EM, Van Moer, E, Zand, E, Reis, FM, Sánchez, F, Terrado, G, Rodrigues, JK, De Meneses e Silva, JM, Smitz, J, Medrano, J, Lee, JR, Winkler-Crepaz, K, Smith, K, Melo e Silva, LHF, Wildt, L, Salama, M, Del Mar Andrés, M, Bourlon, MT, Vega, M, Chehin, MB, De Vos, M, Khrouf, M, Suzuki, N, Azmy, O, Fontoura, P, Campos-Junior, PHA, Mallmann, P, Azambuja, R, Marinho, RM, Anderson, RA, Jach, R, Antunes, RA, Mitchell, R, Fathi, R, Adiga, SK, Takae, S, Kim, SH, Romero, S, Grieco, SC, Shaulov, T, Furui, T, Almeida-Santos, T, Nelen, W, Jayasinghe, Y, Sugishita, Y, and Woodruff, TK
Abstract: Purpose Oncofertility focuses on providing fertility and endocrine-sparing options to patients who undergo life-preserving but gonadotoxic cancer treatment. The resources needed to meet patient demand often are fragmented along disciplinary lines. We quantify assets and gaps in oncofertility care on a global scale. Methods Survey-based questionnaires were provided to 191 members of the Oncofertility Consortium Global Partners Network, a National Institutes of Health–funded organization. Responses were analyzed to measure trends and regional subtleties about patient oncofertility experiences and to analyze barriers to care at sites that provide oncofertility services. Results Sixty-three responses were received (response rate, 25%), and 40 were analyzed from oncofertility centers in 28 countries. Thirty of 40 survey results (75%) showed that formal referral processes and psychological care are provided to patients at the majority of sites. Fourteen of 23 respondents (61%) stated that some fertility preservation services are not offered because of cultural and legal barriers. The growth of oncofertility and its capacity to improve the lives of cancer survivors around the globe relies on concentrated efforts to increase awareness, promote collaboration, share best practices, and advocate for research funding. Conclusion This survey reveals global and regional successes and challenges and provides insight into what is needed to advance the field and make the discussion of fertility preservation and endocrine health a standard component of the cancer treatment plan. As the field of oncofertility continues to develop around the globe, regular assessment of both international and regional barriers to quality care must continue to guide process improvements.
Published: 2018

17. The phenotypic spectrum of congenital Zika syndrome

Author: Del Campo M, Feitosa IM, Ribeiro EM, Horovitz DD, Pessoa AL, França GV, García-Alix A, Doriqui MJ, Wanderley HY, Sanseverino MV, Neri JI, Pina-Neto JM, Santos ES, Verçosa I, Cernach MC, Medeiros PF, Kerbage SC, Silva AA, van der Linden V, Martelli CM, Cordeiro MT, Dhalia R, Vianna FS, Victora CG, Cavalcanti DP, Schuler-Faccini L, and Zika Embryopathy Task Force-Brazilian Society of Medical Genetics ZETF-SBGM
Subjects: disruptive sequence, congenital Zika syndrome, teratogen, congenital Zika infection, dysmorphology, congenital Zika sequence, fetal brain disruption sequence, disruption, Zika virus, teratology
Abstract: In October 2015, Zika virus (ZIKV) outbreak the Brazilian Ministry of Health (MoH). In response, the Brazilian Society of Medical Genetics established a task force (SBGM-ZETF) to study the phenotype of infants born with microcephaly due to ZIKV congenital infection and delineate the phenotypic spectrum of this newly recognized teratogen. This study was based on the clinical evaluation and neuroimaging of 83 infants born during the period from July, 2015 to March, 2016 and registered by the SBGM-ZETF. All 83 infants had significant findings on neuroimaging consistent with ZIKV congenital infection and 12 had confirmed ZIKV IgM in CSF. A recognizable phenotype of microcephaly, anomalies of the shape of skull and redundancy of the scalp consistent with the Fetal Brain Disruption Sequence (FBDS) was present in 70% of infants, but was most often subtle. In addition, features consistent with fetal immobility, ranging from dimples (30.1%), distal hand/finger contractures (20.5%), and feet malpositions (15.7%), to generalized arthrogryposis (9.6%), were present in these infants. Some cases had milder microcephaly or even a normal head circumference (HC), and other less distinctive findings. The detailed observation of the dysmorphic and neurologic features in these infants provides insight into the mechanisms and timings of the brain disruption and the sequence of developmental anomalies that may occur after prenatal infection by the ZIKV.
Published: 2017

18. Influence of different alcohol intake frequencies on alveolar bone loss in adult rats: A sem study

Author: de Souza, DM, primary, Rodrigues, VA, additional, Silva, AA, additional, Gonsalves, VS, additional, Pereira, KA, additional, Nishioka, RS, additional, and de Carvalho, C, additional
Published: 2018
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19. Survey of Third-Party Parenting Options Associated With Fertility Preservation Available to Patients With Cancer Around the Globe

Author: Rashedi, AS, de Roo, SF, Ataman, LM, Edmonds, ME, Silva, AA, Scarella, A, Horbaczewska, A, Anazodo, AC, Arvas, A, Ramalho de Carvalho, B, Rashedi, AS, de Roo, SF, Ataman, LM, Edmonds, ME, Silva, AA, Scarella, A, Horbaczewska, A, Anazodo, AC, Arvas, A, and Ramalho de Carvalho, B
Published: 2017

20. Survey of Fertility Preservation Options Available to Patients With Cancer Around the Globe

Author: Rashedi, AS, de Roo, SF, Ataman, LM, Edmonds, ME, Silva, AA, Scarella, A, Horbaczewska, A, Anazodo, A, Arvas, A, de Carvalho, BR, Sartorio, C, Beerendonk, CCM, Diaz-Garcia, C, Suh, CS, Melo, C, Andersen, CY, Motta, E, Greenblatt, EM, Van Moer, E, Zand, E, Reis, FM, Sanchez, F, Terrado, G, Rodrigues, JK, de Meneses e Silva, JM, Smitz, J, Medrano, J, Lee, JR, Winkler-Crepaz, K, Smith, K, Melo e Silva, LHF, Wildt, L, Salama, M, Andres, MDM, Bourlon, MT, Vega, M, Chehin, MB, De Vos, M, Khrouf, M, Suzuki, N, Azmy, O, Fontoura, P, Almeida Campos-Junior, PH, Mallmann, P, Azambuja, R, Marinho, RM, Anderson, RA, Jach, R, Antunes, RDA, Mitchell, R, Fathi, R, Adiga, SK, Takae, S, Kim, SH, Romero, S, Grieco, SC, Shaulov, T, Furui, T, Almeida-Santos, T, Nelen, W, Jayasinghe, Y, Sugishita, Y, Woodruff, TK, Rashedi, AS, de Roo, SF, Ataman, LM, Edmonds, ME, Silva, AA, Scarella, A, Horbaczewska, A, Anazodo, A, Arvas, A, de Carvalho, BR, Sartorio, C, Beerendonk, CCM, Diaz-Garcia, C, Suh, CS, Melo, C, Andersen, CY, Motta, E, Greenblatt, EM, Van Moer, E, Zand, E, Reis, FM, Sanchez, F, Terrado, G, Rodrigues, JK, de Meneses e Silva, JM, Smitz, J, Medrano, J, Lee, JR, Winkler-Crepaz, K, Smith, K, Melo e Silva, LHF, Wildt, L, Salama, M, Andres, MDM, Bourlon, MT, Vega, M, Chehin, MB, De Vos, M, Khrouf, M, Suzuki, N, Azmy, O, Fontoura, P, Almeida Campos-Junior, PH, Mallmann, P, Azambuja, R, Marinho, RM, Anderson, RA, Jach, R, Antunes, RDA, Mitchell, R, Fathi, R, Adiga, SK, Takae, S, Kim, SH, Romero, S, Grieco, SC, Shaulov, T, Furui, T, Almeida-Santos, T, Nelen, W, Jayasinghe, Y, Sugishita, Y, and Woodruff, TK
Abstract: PURPOSE: Oncofertility focuses on providing fertility and endocrine-sparing options to patients who undergo life-preserving but gonadotoxic cancer treatment. The resources needed to meet patient demand often are fragmented along disciplinary lines. We quantify assets and gaps in oncofertility care on a global scale. METHODS: Survey-based questionnaires were provided to 191 members of the Oncofertility Consortium Global Partners Network, a National Institutes of Health-funded organization. Responses were analyzed to measure trends and regional subtleties about patient oncofertility experiences and to analyze barriers to care at sites that provide oncofertility services. RESULTS: Sixty-three responses were received (response rate, 25%), and 40 were analyzed from oncofertility centers in 28 countries. Thirty of 40 survey results (75%) showed that formal referral processes and psychological care are provided to patients at the majority of sites. Fourteen of 23 respondents (61%) stated that some fertility preservation services are not offered because of cultural and legal barriers. The growth of oncofertility and its capacity to improve the lives of cancer survivors around the globe relies on concentrated efforts to increase awareness, promote collaboration, share best practices, and advocate for research funding. CONCLUSION: This survey reveals global and regional successes and challenges and provides insight into what is needed to advance the field and make the discussion of fertility preservation and endocrine health a standard component of the cancer treatment plan. As the field of oncofertility continues to develop around the globe, regular assessment of both international and regional barriers to quality care must continue to guide process improvements.
Published: 2017

21. Emerging treatment options for the mucopolysaccharidoses

Author: Matte U, Baldo G, Mayer FQ, Netto CB, de Souza CF, Bittar CM, Silva AA, Federhen A, and Giugliani R
Subjects: lcsh:Internal medicine, lcsh:RC648-665, lcsh:Specialties of internal medicine, lcsh:RC581-951, lcsh:R, lcsh:Medicine, lcsh:RC31-1245, lcsh:Diseases of the endocrine glands. Clinical endocrinology
Abstract: Roberto Giugliani,1–6 Andressa Federhen,1,4 André Anjos da Silva,1,5 Camila Matzenbacher Bittar,1,5 Carolina Fischinger Moura de Souza,1 Cristina Brinckmann Oliveira Netto,1 Fabiana Mayer,2,7 Guilherme Baldo,1,2,8 Ursula Matte1–51Medical Genetics Service, 2Gene Therapy Center, Hospital de Clínicas (HCPA), Porto Alegre, RS, Brazil; 3Department of Genetics, 4Postgraduate Program in Child and Adolescent Health, 5Postgraduate Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; 6National Institute of Population Medical Genetics (INAGEMP), Porto Alegre, RS, Brazil; 7Fundação Estadual de Pesquisa Agropecuária (FEPAGRO), Eldorado do Sul, RS, Brazil; 8Department of Biophysics, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, BrazilAbstract: The mucopolysaccharidoses (MPS) are a group of diseases arising from one of eleven different enzyme defects, each one affecting one single step of the degradation pathway of glycosamynoglycans. Several developments in the understanding of the MPS have occurred since the first clinical report about their occurrence in 1917: the nature of the storage product was recognized, a useful biomarker (mucopolysacchariduria) was developed, the enzyme defects became identified, and the gene defects were elucidated. The first successful treatment for MPS diseases was bone marrow transplantation, which was introduced for the therapy in 1980. Over the last decade, a whole new set of therapeutic approaches have become available or are currently in development to address MPS. Intravenous enzyme replacement therapy, already approved for MPS I, II, and VI, will possibly be available for MPS IVA and for MPS VII within the next few years. Intrathecal enzyme replacement therapy (tested in animals and already reported in a few patients) may become a tool to treat or prevent the central nervous system (CNS) manifestations which occur in several MPS. Substrate inhibition therapy using small molecules which cross the blood–brain barrier is also being tested for MPS types with CNS manifestations. In vitro studies point out that chaperones may also be of therapeutic value when the main cause is protein misfolding and retention at the endoplasmic reticulum. Stop-codon read-through strategy has been tried in preclinical studies with MPS models caused by nonsense mutations. Preclinical studies assessing gene therapy also show quite encouraging results, and this modality of treatment is now moving toward clinical development. The use of neural stem cells in MPS types which have CNS involvement is also promising. It is important to point out that MPS diseases are hard to treat, and demand specific therapies with a broad range of supportive measures. An additional challenge arises from the high cost of these technology intensive approaches, and this needs to be addressed if the treatments are to become widely available. Finally, since there is evidence that early diagnosis followed by early treatment considerably improves the health outcomes for these patients, newborn screening is becoming increasingly important for the early diagnosis of affected patients.Keywords: mucopolysaccharidoses, glycosaminoglycans, treatment, enzyme replacement therapy, gene therapy, lysosomal diseases
Published: 2012

22. Comparação entre duas coortes de mães adolescentes em município do Sudeste do Brasil

Author: da Silva Aa, Marco Antonio Barbieri, Heloisa Bettiol, and Eleonora Ro Ribeiro
Subjects: pregnancy in adolescence, Baixo peso ao nascer, Serviços de saúde materna, Mothers, Prenatal care, Adolescent age, Birth rate, infant, low birth weigth, Gravidez na adolescência, Prematuro, Mães, medicine, Childbirth, Pregnancy, business.industry, lcsh:Public aspects of medicine, Cuidado pré-natal, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Single mothers, medicine.disease, Pregnancy in adolescence, mothers, Low birth weight, Fatores socioeconômicos, prenatal care, medicine.symptom, business, Infant, low birth weigth, Demography, Cohort study
Abstract: OBJETIVO: Comparar a prevalência de gravidez na adolescência e analisar variáveis sociobiológicas relacionadas ao binômio mãe-filho entre duas coortes de mães adolescentes de nascidos vivos em Ribeirão Preto (1978-1979 e 1994). MÉTODOS: Foram entrevistadas mães adolescentes logo após o parto, sendo 943 em 1978/79 e 499 em 1994, abrangendo nascidos vivos de parto único, de famílias residentes em Ribeirão Preto, SP. Foi utilizado o teste do qui-quadrado, com nível de significância de 0,05. RESULTADOS: O percentual de mães adolescentes aumentou de 14,1% em 1978/79 para 17,5% em 1994 (p
Published: 2000

23. Cobertura de puericultura e fatores associados em São Luís (Maranhão), Brasil

Author: Uilho Antônio Gomes, da Silva Aa, da Silva Ra, and Tonial
Subjects: medicine.medical_specialty, education.field_of_study, lcsh:Arctic medicine. Tropical medicine, Cross-sectional study, business.industry, lcsh:RC955-962, lcsh:Public aspects of medicine, Confounding, Population, lcsh:R, Public Health, Environmental and Occupational Health, lcsh:Medicine, lcsh:RA1-1270, Family income, Confidence interval, Family planning, Family medicine, Relative risk, medicine, Cluster sampling, education, business
Abstract: Pediatric care is fundamental to preventing several diseases during the early years of childhood. Early medical care and having at least nine checkups in the first year of life are the ideal in pediatric care. It is essential to periodically assess whether or not these goals are being met. In 1994, a cross-sectional study was carried out using three-stage cluster sampling to measure coverage of pediatric care and factors associated with that care among children in the city of Sao Luis, in the state of Maranhao, Brazil. For data collection, a standardized questionnaire was used with the mother of the child or another person responsible for the child. The percentage of those refusing to participate or who were absent was 7%. This work analyzes data concerning 290 children between 1 and 23 months of age. The coverage estimates and 95% confidence intervals took into consideration possible effects of the study design. Cox's regression, modified for cross-sectional studies, was used to estimate adjusted relative risks. Pediatric care coverage for the population studied was 80%. The children had an average of 7.8 checkups in the first year; 44% of the children had six or fewer checkups during the first year of life, well below the recommended number. Eighty-one percent of the children were seen in the Brazilian public health care system (Sistema Unico de Saude, SUS), and only 15% used health insurance. After adjusting for confounding factors, the factors "greater number of siblings at home" and "father with four or fewer years of schooling" were associated with not having checkups. After adjustment, family income was not associated with the number of checkups. Encouraging educational activities and perhaps also family planning programs are important strategies for increasing the coverage of pediatric care in the city of Sao Luis.
Published: 1999

24. Zika virus: A new human teratogen? Implications for women of reproductive age

Author: Schuler-Faccini, L, primary, Sanseverino, MTV, additional, Vianna, FSL, additional, da Silva, AA, additional, Larrandaburu, M, additional, Marcolongo-Pereira, C, additional, and Abeche, AM, additional
Published: 2016
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25. Lhermitte-Duclos Disease (Cerebellar Gangliocytoma)

Author: Banerjee T, da Silva Aa, and Coimbra Rl
Subjects: Male, medicine.medical_specialty, Cerebellum, Lhermitte–Duclos disease, Open biopsy, Computed tomography, Diagnosis, Differential, Café au lait spot, medicine, Humans, Cerebellar Neoplasms, Gangliocytoma, medicine.diagnostic_test, business.industry, Ganglioneuroma, Magnetic resonance imaging, General Medicine, medicine.disease, Magnetic Resonance Imaging, Hydrocephalus, medicine.anatomical_structure, Child, Preschool, Radiology, medicine.symptom, Tomography, X-Ray Computed, business
Abstract: We report a case of Lhermitte-Duclos disease (cerebellar gangliocytoma) in a 7-year-old child with café au lait spots and mild cerebellar symptoms. Findings on computed tomography 4 years earlier had been normal. Subsequent development of intracranial hypertension caused by hydrocephalus led to ventriculoperitoneal shunting. The appearance of the cerebellum on magnetic resonance imaging was supportive of the diagnosis, and open biopsy confirmed it.
Published: 1996

26. Morbimortalidade infantil por diarréia aguda em área metropolitana da região Nordeste do Brasil, 1986-1989

Author: Novochadlo Ma, Galvao Ce, da Silva Aa, dos Reis Filho Sa, da Silva Ra, and Campos Gde J
Subjects: Acute diarrhea, Under-five, business.industry, Public Health, Environmental and Occupational Health, Medicine, Population based, business, Metropolitan area, Infant mortality, Demography, Cause of death
Abstract: Foi realizado inquérito domiciliar do tipo transversal abrangendo crianças menores de cinco anos residentes em 3 áreas da ilha de São Luís (Brasil): Vila Palmeira, Anjo da Guarda e São José de Ribamar. Aplicou-se um questionário onde se perguntou à mãe ou à pessoa responsável pela criança sobre a presença de diarréia nas duas últimas semanas. Foram realizados dois estudos censitários (maio de 1986 e 1989) e quatro amostragens sazonais (novembro de 1986, 1987 e 1988 e maio de 1989). A prevalência de diarréia foi maior em maio de 1986 e novembro de 1987; São José de Ribamar foi o local de maior prevalência; a distribuição dos casos por idade mostrou maior prevalência entre crianças de 6 a 11 meses e de 1 a 2 anos de idade; a prevalência da diarréia foi maior nas famílias que tinham como destino dos dejetos a maré e fossa negra; que se abasteciam de água de poço descoberto, nas famílias cujos pais eram desempregados e nas que depositavam o lixo na maré. A diarréia foi a principal causa de morte nos dois estudos censitários; a taxa de mortalidade infantil em maio de 1986 foi, respectivamente, de 44,0 por mil em menores de um ano e 12,8 por mil em menores de cinco anos; em maio de 1989 foi de 7,9 por mil e 4,9 por mil. As reduções na morbidade e mortalidade infantil por diarréia aguda entre 1986 e 1989 foram estatisticamente significantes.
Published: 1995

27. A PROSPECTIVE EVALUATION OF PRIMIGRAVIDAE MOTHERS' SLEEP PATTERN

Author: Viegas, Carlos, Rodrigues, RN, Silva, AA, and Arboes, HD Jr.
Subjects: Sleep -- Stages, Pregnant women -- Health aspects, Health, Health aspects
Abstract: Carlos Viegas, MD, FCCP(*); RN Rodrigues, MD; AA Silva, MD and HD Arboes, Jr., MD. Hospital Universitario de Brasilia-UnB, Brasilia, DF, Brazil. PURPOSE: Prior studies have reported increased daytime sleepiness [...]
Published: 2000

28. Health-related factors associated with intimate partner violence in women attending a primary care clinic in south-western Nigeria

Author: Silva, AA, primary, Irabor, A, additional, Olowookere, OO, additional, Owoaje, E, additional, and Adebusoye, LA, additional
Published: 2015
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29. CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis

Author: Marino, APMP, Silva, AA, Santos, PVA, Pinto, LMO, Gazinelli, RT, Teixeira, MM, and Lannes-Vieira, J
Subjects: Met-RANTES, Trypanosoma cruzi, parasitic diseases, CC-chemokine receptors, myocarditis, CC-chemokines
Abstract: The comprehension of the pathogenesis of Trypanosoma cruzi-elicited myocarditis is crucial to delineate new therapeutic strategies aiming to ameliorate the inflammation that leads to heart dysfunction, without hampering parasite control. The augmented expression of CCL5/RANTES and CCL3/MIP-1alpha, and their receptor CCR5, in the heart of T. cruzi-infected mice suggests a role for CC-chemokines and their receptors in the pathogenesis of T. cruzi-elicited myocarditis. Herein, we discuss our recent results using a CC-chemokine receptor inhibitor (Met-RANTES), showing the participation of CC-chemokines in T. cruzi infection and unraveling CC-chemokine receptors as an attractive therapeutic target for further evaluation in Chagas disease.
Published: 2005

30. Isolation of the constituents and evaluation of allelopathic potential of Raphanus sativus L. (Brassicaceae)

Author: Fiorucci, LLR, primary, Mantovanelli, GC, additional, Bernardi, DI, additional, Silva, AA, additional, de Oliveira Jr, RS, additional, Ishii- Iwamoto, EL, additional, Sarragiotto, MH, additional, and Baldoqui, DC, additional
Published: 2014
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31. O Cuidado de si entre Profissionais de Enfermagem: Revisão das Dissertações e Teses Brasileiras

Author: SILVA, AA, primary, TERRA, MG, additional, GONÇALVES, MO, additional, and SOUTO, VT, additional
Published: 2014
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32. Characteristics of adolescent pregnancy, Brazil

Author: Tonial, Fernando Lamy-Filho, da Silva Aa, Heloisa Bettiol, Vanda Maria Ferreira Simões, and Elba Gomide Mochel
Subjects: pregnancy in adolescence, medicine.medical_treatment, Serviços de saúde materna, Infant mortality, Parto, risk factors, Medicine, media_common, maternal health services, lcsh:Public aspects of medicine, Smoking, infant, low birth weight, infant mortality, Fatores socioeconômicos, Maternal health services, Qualidade dos cuidados de saúde, pregnancy rate, prenatal care, Prenatal care, iinfant, prematur, medicine.symptom, Mortalidade infantil, Tabagismo, media_common.quotation_subject, Infant, low birth weight, Iinfant, prematur, socioeconomic factors, Fertility, Socioeconomic factors, adolescent behavior, smoking, Pregnancy rate, Gravidez na adolescência, quality of health care, Prematuro, Caesarean section, parturition, Socioeconomic status, Pregnancy, Fatores de risco, business.industry, Cuidado pré-natal, Parturition, Public Health, Environmental and Occupational Health, Comportamento do adolescente, lcsh:RA1-1270, Anthropometry, medicine.disease, Pregnancy in adolescence, Low birth weight, Coeficiente de fecundidade, Risk factors, Quality of health care, business, Recém-nascido de baixo peso, Adolescent behavior, Demography
Abstract: OBJETIVO: Identificar as principais características socioeconômicas, demográficas, antropométricas e comportamentais, bem como os resultados perinatais da gravidez na adolescência. Conhecer os tipos de serviços de saúde utilizados pelas gestantes adolescentes. MÉTODOS: A amostra de 2.429 partos de mulheres residentes em São Luís, MA, abrangeu 94% dos nascimentos hospitalares. As mulheres foram separadas em seis grupos de idade para melhor avaliação do comportamento das variáveis entre os dois grupos de adolescentes (abaixo de 18 anos; 18 a 19 anos) e entre as adolescentes e as demais mulheres. O teste do qui-quadrado foi utilizado para a comparação de proporções e a razão de prevalências foi empregada como medida de efeito. RESULTADOS: Das 2.429 mulheres, 714 eram adolescentes (29,4%). Seu coeficiente específico de fecundidade, 72,2 por mil, foi mais elevado que em outras regiões do País. As adolescentes apresentaram piores condições socioeconômicas e reprodutivas que as demais mulheres, maior proporção de pré-natal inadequado (39,2%) e muitas não tinham companheiro (34,5%). Por outro lado, tiveram menor proporção de parto cesáreo (23,0%) e de fumantes (3.5%). CONCLUSÕES: Apesar da situação socioeconômica igualmente desfavorável, as adolescentes de 18 a 19 anos apresentaram resultados perinatais semelhantes às mulheres de 25 a 29 anos. Já as menores de 18 anos tiveram maiores proporções de filhos com baixo peso ao nascer, prematuros e com maior risco de mortalidade infantil. Isto sugere que a imaturidade biológica possa estar associada a maiores taxas de prematuridade, baixo peso ao nascer e mortalidade infantil. OBJECTIVE: To identify the main socioeconomic, demographic, anthropometric and behavioral characteristics, and pregnancy outcomes of adolescent pregnancy and to assess health services used by pregnant adolescents. METHODS: Data were collected from a cross-section of 2,429 deliveries by women residing in the municipality of São Luís, Brazil, of which 94% were hospital births. Women were categorized into six age groups. The two groups of teenagers (under 18 and 18-19 years) were compared to four groups of older women. Comparison was also made between the two teenage groups. The chi-square test was used to compare proportions and prevalence ratio was used as an effect measure. RESULTS: Of 2,429 women, 714 (29.4%) were adolescents. Their specific fertility coefficient was higher than in other regions of the country. Adolescents showed lower socioeconomic and reproductive conditions than older women and a higher proportion of inadequate prenatal care. The majority had no partner. They had the lowest percentages of caesarean section and smokers. CONCLUSIONS: Despite their equally unfavorable socioeconomic situation, 18-19 year-old adolescents had pregnancy outcomes comparable to the age group 25-29, whereas those under 18 had the highest proportions of low birth weight, preterm birth, and infant mortality rate. This suggests that biologic immaturity may be associated with adverse pregnancy outcomes.
Published: 2003

33. Epidemia de dengue em Ribeirão Preto, SP, Brasil: nota prévia

Author: Vilma Delphino de Oliveira Garotti, Dal Fabbro Al, Rocha Gde M, Luis Tadeu Moraes Figueiredo, Castro e Silva Aa, Ricardo José Soares Pontes, Roseli Claudino Santiago, and Josely Mendonça Pereira Pintyá
Subjects: medicine.medical_specialty, Dengue hemorrhagic fever, business.industry, Public Health, Environmental and Occupational Health, Outbreak, medicine.disease, Dengue shock syndrome, Dengue fever, Shock (circulatory), Emergency medicine, medicine, Level ii, medicine.symptom, business
Abstract: Apresenta-se Nota preliminar de uma epidemia de dengue, ocorrida em Ribeirão Preto, São Paulo, Brasil, no período de novembro de 1990 a março de 1991. Descreve-se a ocorrência de um caso de "Dengue Hemorrhagic Fever/Dengue Shock Syndrome" Grau II (DHF/DSS) e de dois óbitos associados ao dengue devido a síndrome de choque. Alerta clínicos e epidemiologistas quanto à possibilidade de ocorrência de casos isolados de DHF/DSS durante epidemias de dengue clássico em áreas antes indenes à doença.
Published: 1991

34. Myorelaxant effects of methyl cinnamate, the major constituent of the essential oil of Ocimum micranthum, on smooth muscle of the gastrointestinal tract of rats

Author: Lima, FJ, primary, Soares, MA, additional, Vasconcelos-Silva, AA, additional, Ribeiro-Filho, HV, additional, Cosker, F, additional, Souza, MH, additional, and Magalhães, PJ, additional
Published: 2013
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35. Water-contact patterns and risk factors for Schistosoma mansoni infection in a rural village of northeast Brazil

Author: Tonial, Borges Dp, Coimbra Lc, Cutrim Rn, de Britto e Alves Mt e Alves Mt, and da Silva Aa
Subjects: Adult, Male, Bathing, Adolescent, Schistosomiasis, Rural Health, Persistence (computer science), Risk Factors, Environmental health, medicine, Prevalence, Humans, Child, Socioeconomic status, biology, Sewage, Proportional hazards model, Confounding, Infant, Newborn, Infant, Water, Systematic sampling, General Medicine, Middle Aged, medicine.disease, biology.organism_classification, Schistosomiasis mansoni, Infectious Diseases, Geography, Child, Preschool, Female, Schistosoma mansoni, Brazil
Abstract: Schistosomiasis mansoni in the Serrano village, municipality of Cururupu, state of Maranhão, Brazil, is a widely spread disease. The PECE (Program for the Control of Schistosomiasis), undertaken since 1979 has reduced the prevalence of S. mansoni infection and the hepatosplenic form of the disease. Nevertheless piped water is available in 84% of the households, prevalence remains above 20%. In order to identify other risk factors responsible for the persistence of high prevalence levels, a cross-sectional survey was carried out in a systematic sample of 294 people of varying ages. Socioeconomic, environmental and demographic variables, and water contact patterns were investigated. Fecal samples were collected and analyzed by the Kato-Katz technique. Prevalence of S. mansoni infection was 24.1%, higher among males (35.5%) and between 10-19 years of age (36.6%). The risk factors identified in the univariable analysis were water contacts for vegetable extraction (Risk Ratio - RR = 2.92), crossing streams (RR = 2.55), bathing (RR = 2.35), fishing (RR = 2.19), hunting (RR = 2.17), cattle breeding (RR = 2.04), manioc culture (RR = 1.90) and leisure (RR = 1.56). After controlling for confounding variables by proportional hazards model the risks remained higher for males, vegetable extraction, bathing in rivers and water contact in rivers or in periodically inundated parts of riverine woodland (swamplands)
Published: 1997

36. The effects of urine level, duration of treatment and moisture level on nutritive value of wheat straw

Author: Cadavez, Vap, Dias-Da-Silva, Aa, and Revues Inra, Import
Subjects: [SDV.SA.ZOO] Life Sciences [q-bio]/Agricultural sciences/Zootechny, ComputingMilieux_MISCELLANEOUS
Published: 1996

37. Vasorelaxation induced by (-)-α-Bisabolol in rat aorta is preferential to voltage-operated contractile pathways

Author: de Siqueira, RJB, primary, Cosker, F, additional, Freire, RS, additional, Freire, WBS, additional, Fonseca-Magalhães, PA, additional, Vasconcelos-Silva, AA, additional, Ferreira, LC, additional, Roque, CR, additional, Lahlou, S, additional, and Magalhães, PJC, additional
Published: 2012
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38. PLUNC protein expression in major salivary glands of HIV-infected patients

Author: da Silva, AA, primary, Bingle, L, additional, Speight, PM, additional, Bingle, CD, additional, Mauad, T, additional, da Silva, LFF, additional, and Vargas, PA, additional
Published: 2010
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39. Associação entre idade, classe social e hábito de fumar maternos com peso ao nascer

Author: Uilho Antônio Gomes, Dal Bo Cm, Marco Antonio Barbieri, da Silva Aa, Heloisa Bettiol, and Gerson Mucillo
Subjects: medicine.medical_specialty, Offspring, Baixo peso ao nascer, Birth weight, media_common.quotation_subject, Infant, low birth weight, Prenatal care, Social class, smoking, Epidemiology, Medicine, Maternal age, media_common, Fumo/efeitos adversos, Middle class, Idade materna, business.industry, Singleton, lcsh:Public aspects of medicine, Smoking, Public Health, Environmental and Occupational Health, infant, low birth weight, Fumo, lcsh:RA1-1270, Working class, maternal age, social class, business, Classe Social, Demography
Abstract: Foi realizado inquérito em Ribeirão Preto, Brasil, de junho de 1978 a maio de 1979, que constou de entrevistas com mães de nascidos vivos hospitalares, de partos únicos, correspondendo a 98 % dos nascimentos ocorridos durante o período no Município. O maior percentual de nascimentos com baixo peso ocorreu entre as mães jovens, fumantes e pertencentes às classes trabalhadoras. O maior número de mães jovens foi encontrado também nessas classes. A prevalência do hábito de fumar foi maior nas mães jovens, porém houve pouca diferença na freqüência de mulheres fumantes entre as classes sociais, variando de 25 a 30%. Observou-se que o pencentual de baixo peso foi maior para as mães trabalhadoras não fumantes do que para as mães burguesas fumantes. O modelo logito foi ajustado aos dados para estudo da possível associação múltipla entre hábito de fumar, idade materna e classe social com o peso ao nascer. Os resultados indicaram que hábito de fumar materno, idade materna e classe social foram independentes no seu efeito sobre o peso ao nascer, não se observando interação. Esses achados sugerem que a maior prevalência de baixo peso entre mães não fumantes das classes trabalhadoras em relação às mães fumantes da burguesia provavelmente refletiu a concentração de outros fatores de risco entre as mulheres das classes trabalhadoras, tais como: baixa escolaridade, cuidado pré-natal inadequado, alta paridade, diferenças no comportamento reprodutivo. An epidemiological survey was carried out in Ribeirão Preto, Brazil, from June 1978 to May 1979. Interviews were held with mother of singleton live borne children, delivered in hospitals, which accounted for 98% of all births in the area. The higher percentages of low birthweight children related to the offspring of smokers, young mother and women belonging to the working class. The majority of young women were found in the working class and the prevalence of smoking was higher in the group of women below 20 years of age. There was no statistical difference in the smoking habit as between different social classes. A larger number of low birthweight children were observed in nonsmoking women of the working class than among women smokers of the middle class. A log model was adjusted to the data in order to study the possible multiple association of smoking, maternal age and social class with birthweight. The results indicated that maternal smoking, maternal age and social class had independent effects on birthweight. The was no interaction between them. These findings suggest that the higher prevalence of low birthweight in nonsmoking mothers of the working class in relation to smoking mothers of the middle class probably reflects clustering of other risk factors-such as poor education inadequate prenatal care, high parity and differences in reproductive behavior in women of the working class.
Published: 1992

40. CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis

Author: Marino, APMP, primary, Silva, AA, additional, Santos, PVA, additional, Pinto, LMO, additional, Gazinelli, RT, additional, Teixeira, MM, additional, and Lannes-Vieira, J, additional
Published: 2005
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41. Haemorragic acute abdomen after oocyte retrievel for in vitro fertilization

Author: Silva, AA, primary, Iglesias, JR, additional, Barbosa, ACP, additional, Cabral, IO, additional, Calvano, DC., additional, Sanchez, CP, additional, and Nakagawa, H M, additional
Published: 2002
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42. Interstitial pregnancy after in vitro fertilization with failure to the conservative treatment using methotrexate

Author: Silva, AA, primary, Nakagava, HM, additional, Barbosa, ACP, additional, Iglesias, JR, additional, Cabral, ID, additional, and Cortês, LS, additional
Published: 1999
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43. ICSI implantation program - Preliminary outcomes

Author: Silva, AA, primary, Cabral, IO, additional, Nakagava, HM, additional, Barbosa, ACP, additional, Iglesias, JR, additional, Rabelo, RP, additional, and Nolasco, LAP, additional
Published: 1997
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44. The effects of urine level, duration of treatment and moisture level on nutritive value of wheat straw

Author: Cadavez, VAP, primary and Bias-Da-Silva, AA, additional
Published: 1996
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45. Role of leptin and central nervous system melanocortins in obesity hypertension.

Author: da Silva AA, Carmo JM, Hall JE, da Silva, Alexandre A, do Carmo, Jussara M, and Hall, John E
Published: 2013
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46. Severe food insecurity is associated with obesity among Brazilian adolescent females.

Author: Kac G, Velásquez-Melendez G, Schlüssel MM, Segall-Côrrea AM, Silva AA, Pérez-Escamilla R, Kac, Gilberto, Velásquez-Melendez, Gustavo, Schlüssel, Michael M, Segall-Côrrea, Ana Maria, Silva, Antônio Am, and Pérez-Escamilla, Rafael
Abstract: Objective: To determine whether household food insecurity (HFI) is associated with a higher prevalence of excessive weight (EW) in a large random sample of Brazilian female adolescents.Design: Nationally representative cross-sectional study. EW was the outcome variable (BMI ≥ 85th percentile of WHO reference for adolescents aged 15-18 years and BMI ≥ 25 kg/m(2) for those aged 19 years). HFI was measured with the Brazilian Food Insecurity Scale. Associations were measured using crude and adjusted prevalence ratios (PR) with 95 % confidence intervals through Poisson regression models taking into account the complex sampling design.Setting: Data were derived from the third wave of the Demographic and Health Survey conducted in 2006-2007, in Brazil.Subjects: The sample included 1529 female adolescents aged 15-19 years.Results: The prevalence of any level of HFI was 40.8 %, with 26.6 % of households experiencing mild, 9.4 % moderate and 4.8 % severe food insecurity. The overall prevalence of EW was 21.9 % (12.9 % were overweight and 9.0 % obese). EW prevalence among those living in severely, moderately and mildly food-insecure households was 36.8 %, 14.9 % and 16.5 %, respectively (P for the overall association = 0.036). Women living in severely food-insecure households had an increased prevalence of EW compared with their food-secure counterparts (PR = 1.96; 95 % CI 1.18, 3.27; P = 0.007), after adjusting for important confounders.Conclusions: The study suggests that severe but not mild or moderate HFI is independently associated with EW among adolescents residing in Brazil, a middle-income country undergoing the nutrition transition. [ABSTRACT FROM AUTHOR]
Published: 2012
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47. PLUNC protein expression in major salivary glands of HIV-infected patients.

Author: da Silva, AA, Bingle, L, Speight, PM, Bingle, CD, Mauad, T, da Silva, LFF, and Vargas, PA
Subjects: *PROTEIN analysis, *ANALYSIS of variance, *COMPUTER software, *HIV infections, *HIV-positive persons, *IMMUNOHISTOCHEMISTRY, *SALIVA, *SALIVARY glands, *SEX distribution, *STATISTICS, *U-statistics, *SAMPLE size (Statistics), *DATA analysis
Abstract: Oral Diseases (2011) , 258-264 To analyse and compare the expression of Palate, Lung, and Nasal Epithelium Clone (PLUNC) proteins in salivary glands from patients with and without AIDS (control group) using autopsy material. We analysed the expression of PLUNCs using immunohistochemistry in parotid ( n = 45), submandibular ( n = 47) and sublingual gland ( n = 37) samples of AIDS patients [30 with normal histology, 21 with mycobacteriosis, 14 with cytomegalovirus (CMV) infection, 30 with chronic non-specific sialadenitis, and 30 HIV-negative controls. In situ hybridization (ISH) for SPLUNC 2 in the HIV-negative group was performed. SPLUNC 1 expression was detected in the mucous acini of submandibular and sublingual glands, and SPLUNC 2 were seen in the serous cells. LPLUNC 1 expression was only positive in the salivary ducts. There was a higher expression of SPLUNC 2 in AIDS patients with CMV infection and mycobacteriosis when compared with all other groups. The intensity of staining for SPLUNC 2 was greater around the lesions than the peripheral ones. ISH for SPLUNC 2 showed perinuclear positivity in the serous cells in all HIV-negative cases. SPLUNC 1 and LPLUNC 1 proteins were similarly expressed in the salivary glands of AIDS patients and non-HIV patients. CMV infection and mycobacteriosis increase SPLUNC 2 expression in serous cells in the salivary gland of AIDS patients. [ABSTRACT FROM AUTHOR]
Published: 2011
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48. Chronic blood pressure and appetite responses to central leptin infusion in rats fed a high fat diet.

Author: Dubinion JH, da Silva AA, and Hall JE
Published: 2011
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49. Enhanced blood pressure and appetite responses to chronic central melanocortin-3/4 receptor blockade in dietary-induced obesity.

Author: Dubinion JH, da Silva AA, Hall JE, Dubinion, John H, da Silva, Alexandre A, and Hall, John E
Published: 2010
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50. Association of the length polymorphism in the human Per3 gene with the delayed sleep-phase syndrome: does latitude have an influence upon it?

Author: Pereira DS, Tufik S, Louzada FM, Benedito-Silva AA, Lopez AR, Lemos NA, Korczak AL, D'Almeida V, and Pedrazzoli M
Published: 2005

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