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14 results on '"Silva, Nicole R."'

3. Distinct sex-dependent behavioral responses induced by two positive allosteric modulators of alpha 5 subunit-containing GABAA receptors

Author

Souza, Adriana Jesus, Cortez, Isadora L., Silva, Nicole R., Pedrazzi, João Francisco C., Domingos, Luana B., Braga, Matheus Silva, Santos-Silva, Thamyris, Del-Bel, Elaine A., Resstel, Leonardo B.M., Li, Guanguan, Mian, Md Yeunus, Sharmin, Dishary, Guimarães, Francisco S., Cook, James M., and Gomes, Felipe V.

Published
2022
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7. Supplementary Figure from PD-1/PD-L1 Inhibition Enhances Chemotherapy-Induced Neuropathic Pain by Suppressing Neuroimmune Antinociceptive Signaling

Author

Wanderley, Carlos Wagner S., primary, Maganin, Alexandre G.M., primary, Adjafre, Beatriz, primary, Mendes, Atlante S., primary, Silva, Conceição Elidianne Anibal, primary, Quadros, Andreza Urba, primary, Luiz, João Paulo Mesquita, primary, Silva, Camila Meirelles S., primary, Silva, Nicole R., primary, Oliveira, Francisco Fabio Bezerra, primary, Gomes, Francisco Isaac F., primary, Restrepo, Jeferson Leandro J., primary, Speck-Hernandez, Cesar A., primary, Turaça, Fernanda, primary, Silva, Gabriel Victor Lucena, primary, Pigatto, Glauce R., primary, Nakaya, Helder I., primary, Mota, Jose Mauricio, primary, Barroso-Sousa, Romualdo, primary, Alves-Filho, José C., primary, Cunha, Thiago M., primary, and Cunha, Fernando Q., primary

Published
2023
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8. Supplementary Data from PD-1/PD-L1 Inhibition Enhances Chemotherapy-Induced Neuropathic Pain by Suppressing Neuroimmune Antinociceptive Signaling

Author

Wanderley, Carlos Wagner S., primary, Maganin, Alexandre G.M., primary, Adjafre, Beatriz, primary, Mendes, Atlante S., primary, Silva, Conceição Elidianne Anibal, primary, Quadros, Andreza Urba, primary, Luiz, João Paulo Mesquita, primary, Silva, Camila Meirelles S., primary, Silva, Nicole R., primary, Oliveira, Francisco Fabio Bezerra, primary, Gomes, Francisco Isaac F., primary, Restrepo, Jeferson Leandro J., primary, Speck-Hernandez, Cesar A., primary, Turaça, Fernanda, primary, Silva, Gabriel Victor Lucena, primary, Pigatto, Glauce R., primary, Nakaya, Helder I., primary, Mota, Jose Mauricio, primary, Barroso-Sousa, Romualdo, primary, Alves-Filho, José C., primary, Cunha, Thiago M., primary, and Cunha, Fernando Q., primary

Published
2023
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9. Data from PD-1/PD-L1 Inhibition Enhances Chemotherapy-Induced Neuropathic Pain by Suppressing Neuroimmune Antinociceptive Signaling

Author

Wanderley, Carlos Wagner S., primary, Maganin, Alexandre G.M., primary, Adjafre, Beatriz, primary, Mendes, Atlante S., primary, Silva, Conceição Elidianne Anibal, primary, Quadros, Andreza Urba, primary, Luiz, João Paulo Mesquita, primary, Silva, Camila Meirelles S., primary, Silva, Nicole R., primary, Oliveira, Francisco Fabio Bezerra, primary, Gomes, Francisco Isaac F., primary, Restrepo, Jeferson Leandro J., primary, Speck-Hernandez, Cesar A., primary, Turaça, Fernanda, primary, Silva, Gabriel Victor Lucena, primary, Pigatto, Glauce R., primary, Nakaya, Helder I., primary, Mota, Jose Mauricio, primary, Barroso-Sousa, Romualdo, primary, Alves-Filho, José C., primary, Cunha, Thiago M., primary, and Cunha, Fernando Q., primary

Published
2023
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11. PD-1/PD-L1 Inhibition Enhances Chemotherapy-Induced Neuropathic Pain by Suppressing Neuroimmune Antinociceptive Signaling

Author

Wanderley, Carlos Wagner S., primary, Maganin, Alexandre G.M., additional, Adjafre, Beatriz, additional, Mendes, Atlante S., additional, Silva, Conceição Elidianne Anibal, additional, Quadros, Andreza Urba, additional, Luiz, João Paulo Mesquita, additional, Silva, Camila Meirelles S., additional, Silva, Nicole R., additional, Oliveira, Francisco Fabio Bezerra, additional, Gomes, Francisco Isaac F., additional, Restrepo, Jeferson Leandro J., additional, Speck-Hernandez, Cesar A., additional, Turaça, Fernanda, additional, Silva, Gabriel Victor Lucena, additional, Pigatto, Glauce R., additional, Nakaya, Helder I., additional, Mota, Jose Mauricio, additional, Barroso-Sousa, Romualdo, additional, Alves-Filho, José C., additional, Cunha, Thiago M., additional, and Cunha, Fernando Q., additional

Published
2022
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12. Blockade of bradykinin receptors or angiotensin II type 2 receptor prevents paclitaxel‐associated acute pain syndrome in mice

Author

Zanata, Graziele C., primary, Pinto, Larissa G., additional, Silva, Nicole R., additional, Lopes, Alexandre H. P., additional, Oliveira, Francisco F. B., additional, Schivo, Ieda R. S., additional, Cunha, Fernando Q., additional, McNaughton, Peter, additional, Cunha, Thiago M., additional, and Silva, Rangel L., additional

Published
2020
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13. Blockade of bradykinin receptors or angiotensin II type 2 receptor prevents paclitaxel-associated acute pain syndrome in mice.

Author

Zanata, Graziele C., Pinto, Larissa G., Silva, Nicole R., Lopes, Alexandre H. P., Oliveira, Francisco F. B., Schivo, Ieda R. S., Cunha, Fernando Q., McNaughton, Peter, Cunha, Thiago M., Silva, Rangel L., da Silva, Nicole R, and de Oliveira, Francisco F B

Abstract

Background: Paclitaxel (PCX) is the first-line choice for the treatment of several types of cancer, including breast, ovarian, and lung cancers. However, patients who receive even a single dose with PCX commonly develop mechanical and cold allodynia, a symptom known as PCX-associated acute pain syndrome (P-APS). Here, we assessed possible involvement of kinin-kallikrein and renin-angiotensin systems in P-APS in mice.Methods: Male mice C57Bl/6 wild type (WT) and knockouts for bradykinin receptors, B1 (B1-/- ) and B2 (B2-/- ), were used. Mechanical and cold allodynia were evaluated by using von Frey filaments and acetone test, respectively. P-APS was induced by administration of PCX 4 mg/kg, i.v.. ACE inhibitors (captopril and enalapril), antagonists for angiotensin II type 1 (losartan) and type 2 ([AT2R]; PD123319 and EMA 401) receptors were administrated prior the treatment with PCX. RT-PCR was used to analyse the expression of mRNA for B1, B2 and AT2R receptors.Results: Administration of PCX in B1-/- and B2-/- mice induced lower mechanical and cold allodynia compared to the WT. However, the pre-treatment with ACE inhibitors reduced the development of mechanical and cold allodynia in P-APS. Surprisingly, we found that mice pre-treatment with the PD123319 or EMA401, but not losartan, prevented the development of mechanical and cold allodynia induced by PCX.Conclusion: Our results demonstrated the involvement of bradykinin receptors B1 and B2 as well as AT2R in the induction of P-APS in mice, and suggest the use of AT2R antagonists as a potential therapy for the prevention of P-APS in humans.Significance: Kinin-kallikrein and renin-angiotensin systems, through B1, B2 and AT2 receptors, potentiates paclitaxel-associated acute pain syndrome (P-APS) in mice. Antagonists for AT2R are potential alternatives to prevent P-APS. [ABSTRACT FROM AUTHOR]

Published
2021
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14. A novel peptide that improves metabolic parameters without adverse central nervous system effects

Author

Reckziegel, Patrícia, primary, Festuccia, William T., additional, Britto, Luiz R. G., additional, Jang, Karen L. Lopes, additional, Romão, Carolina M., additional, Heimann, Joel C., additional, Fogaça, Manoela V., additional, Rodrigues, Naielly S., additional, Silva, Nicole R., additional, Guimarães, Francisco S., additional, Eichler, Rosangela A. S., additional, Gupta, Achla, additional, Gomes, Ivone, additional, Devi, Lakshmi A., additional, Heimann, Andrea S., additional, and Ferro, Emer S., additional

Published
2017
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