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4 results on '"Silva, Emanuel Pereira"'

1. Riparin II-type benzamides as novel antibiofilm agents against dermatophytes: chemical synthesis, in vitro, ex vivo and in silico evaluation

Author

Rocha, Marcelo Antônio Nóbrega da, primary, Silva, Emanuel Pereira, additional, Silva, Risley Nikael Medeiros, additional, Sousa, Gabriela Ribeiro de, additional, Barbosa-Filho, José Maria, additional, Maia, Mayara dos Santos, additional, Lima, Alberto Shellygton, additional, de Souza-Ferrari, Jailton, additional, and Pereira, Fillipe de Oliveira, additional

Published
2024
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2. In vitro and ex vivo antibiofilm activity of riparin 1, and its nor and dinor homologs, against dermatophytes

Author

Medeiros Silva, Risley Nikael, primary, Nóbrega da Rocha, Marcelo Antônio, additional, Silva, Emanuel Pereira, additional, Moura-Mendes, Juliana, additional, Ribeiro-Filho, Jaime, additional, de Sousa, Gabriela Ribeiro, additional, de Souza-Ferrari, Jailton, additional, Barbosa-Filho, José Maria, additional, and de Oliveira Pereira, Fillipe, additional

Published
2023
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3. Antifungal and Antibiofilm Activity of Riparin III against Dermatophytes

Author

Silva, Emanuel Pereira, primary, Rocha, Marcelo Antônio Nóbrega da, additional, Silva, Risley Nikael Medeiros, additional, Moura-Mendes, Juliana, additional, Sousa, Gabriela Ribeiro de, additional, de Souza-Ferrari, Jailton, additional, Barbosa-Filho, José Maria, additional, Lima, Edeltrudes de Oliveira, additional, and Pereira, Fillipe de Oliveira, additional

Published
2023
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4. In vitroand ex vivoantibiofilm activity of riparin 1, and its norand dinorhomologs, against dermatophytes

Author

Medeiros Silva, Risley Nikael, Nóbrega da Rocha, Marcelo Antônio, Silva, Emanuel Pereira, Moura-Mendes, Juliana, Ribeiro-Filho, Jaime, de Sousa, Gabriela Ribeiro, de Souza-Ferrari, Jailton, Barbosa-Filho, José Maria, and de Oliveira Pereira, Fillipe

Abstract

ABSTRACTDermatophytosis is one of the most frequent superficial mycoses in the world. They are mainly caused by the dermatophytes Trichophyton rubrumand Microsporum canis. Biofilm production is an essential factor in the pathogenesis of dermatophytes; it confers drug resistance and significantly impairs antifungal effectiveness. Therefore, we evaluated the antibiofilm activity of an alkamide-type alkaloid called riparin 1 (RIP1) against clinically relevant dermatophytes. We also produced synthetic nor(NOR1) and dinor(DINOR1) homologs for pharmacological evaluation, with a 61–70% yield. We used invitro(96-well polystyrene plates) and ex vivo(hair fragments) models to verify the effects of these compounds on the formation and viability of biofilms. RIP1 and NOR1 showed antifungal activity against strains of T. rubrumand M. canis, but DINOR1 showed no significant antifungal activity against the dermatophytes. Furthermore, RIP1 and NOR1 significantly reduced the viability of biofilms invitroand ex vivo(P< 0.05). RIP1 was more potent than NOR1, possibly due to the distance between the p-methoxyphenyl and the phenylamide moieties in these compounds. Due to the significant antifungal and antibiofilm activities observed for RIP1 and NOR1, we suggest that they could be useful in the treatment of dermatophytosis.

Published
2023
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