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11 results on '"Silue, Kigbafori D."'

5. Antiplasmodial activity and acute oral toxicity of Rauvolfia vomitoria leaves extracts

Author

Nkoua-Badzi, Cynthia, Dominique, Tano Konan, Tresor, Dable Marius, Fredy, Nsonde-Ntandou Gelase, Silue, Kigbafori D, Gisele, Kouakou-Siransy, Henri-Joseph, Parra, Herve, Menan, Antoine, Abena Ange, William, Yavo, Nkoua-Badzi, Cynthia, Dominique, Tano Konan, Tresor, Dable Marius, Fredy, Nsonde-Ntandou Gelase, Silue, Kigbafori D, Gisele, Kouakou-Siransy, Henri-Joseph, Parra, Herve, Menan, Antoine, Abena Ange, and William, Yavo

Abstract

Background: Malaria is one of the most important diseases in Republic of Congo with 47.9% of outpatients visit for 64.8% admissions. The rise of antimalarial resistant strains requires the active search of new active compounds and medicinal plants can be an alternative. From an ethnobotanical survey a list of plants with antimalarial reputations was drawn up, including Rauvolfia vomitoria. Aim: The objective of this study is to see if we can validate the supposed activity of Rauvolfia vomitoria and its toxicity. Material and Methods: Rauvolfia vomitoria leaves have been collected, dried and sprayed. Leaves powder were macerated in distilled water for 24 hours. Another part of leaves powder were macerated for 24 hours successively in hexane, dichloromethane, mix of diclhoromethane: methanol (v:v) and methanol. The crude extracts were prepared and tested for antiplasmodial activity on NF54 strains and field isolates with the SYBR Green I-based in vitro assay technique. The extracts with the best antiplasmodial activities were used on rats for acute toxicity. Results: All Rauvolfia vomitoria leaves extracts have shown a very good antiplasmodial activity (0.63 CI50 20.19

Published
2018

6. Erratum for Brunschwig et al., “UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria”

Author

Brunschwig, Christel, primary, Lawrence, Nina, additional, Taylor, Dale, additional, Abay, Efrem, additional, Njoroge, Mathew, additional, Basarab, Gregory S., additional, Le Manach, Claire, additional, Paquet, Tanya, additional, Gonzàlez Cabrera, Diego, additional, Nchinda, Aloysius T., additional, de Kock, Carmen, additional, Wiesner, Lubbe, additional, Denti, Paolo, additional, Waterson, David, additional, Blasco, Benjamin, additional, Leroy, Didier, additional, Witty, Michael J., additional, Donini, Cristina, additional, Duffy, James, additional, Wittlin, Sergio, additional, White, Karen L., additional, Charman, Susan A., additional, Jiménez-Díaz, Maria Belén, additional, Angulo-Barturen, Iñigo, additional, Herreros, Esperanza, additional, Gamo, Francisco Javier, additional, Rochford, Rosemary, additional, Mancama, Dalu, additional, Coetzer, Theresa L., additional, van der Watt, Mariëtte E., additional, Reader, Janette, additional, Birkholtz, Lyn-Marie, additional, Marsh, Kennan C., additional, Solapure, Suresh M., additional, Burke, John E., additional, McPhail, Jacob A., additional, Vanaerschot, Manu, additional, Fidock, David A., additional, Fish, Paul V., additional, Siegl, Peter, additional, Smith, Dennis A., additional, Wirjanata, Grennady, additional, Noviyanti, Rintis, additional, Price, Ric N., additional, Marfurt, Jutta, additional, Silue, Kigbafori D., additional, Street, Leslie J., additional, and Chibale, Kelly, additional

Published
2018
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7. UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

Author

Brunschwig, Christel, primary, Lawrence, Nina, additional, Taylor, Dale, additional, Abay, Efrem, additional, Njoroge, Mathew, additional, Basarab, Gregory S., additional, Le Manach, Claire, additional, Paquet, Tanya, additional, Cabrera, Diego Gonzàlez, additional, Nchinda, Aloysius T., additional, de Kock, Carmen, additional, Wiesner, Lubbe, additional, Denti, Paolo, additional, Waterson, David, additional, Blasco, Benjamin, additional, Leroy, Didier, additional, Witty, Michael J., additional, Donini, Cristina, additional, Duffy, James, additional, Wittlin, Sergio, additional, White, Karen L., additional, Charman, Susan A., additional, Jiménez-Díaz, Maria Belén, additional, Angulo-Barturen, Iñigo, additional, Herreros, Esperanza, additional, Gamo, Francisco Javier, additional, Rochford, Rosemary, additional, Mancama, Dalu, additional, Coetzer, Theresa L., additional, van der Watt, Mariëtte E., additional, Reader, Janette, additional, Birkholtz, Lyn-Marie, additional, Marsh, Kennan C., additional, Solapure, Suresh M., additional, Burke, John E., additional, McPhail, Jacob A., additional, Vanaerschot, Manu, additional, Fidock, David A., additional, Fish, Paul V., additional, Siegl, Peter, additional, Smith, Dennis A., additional, Wirjanata, Grennady, additional, Noviyanti, Rintis, additional, Price, Ric N., additional, Marfurt, Jutta, additional, Silue, Kigbafori D., additional, Street, Leslie J., additional, and Chibale, Kelly, additional

Published
2018
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9. Erratum for Brunschwig et al., “UCT943, a Next-Generation Plasmodium falciparumPI4K Inhibitor Preclinical Candidate for the Treatment of Malaria”

Author

Brunschwig, Christel, Lawrence, Nina, Taylor, Dale, Abay, Efrem, Njoroge, Mathew, Basarab, Gregory S., Le Manach, Claire, Paquet, Tanya, Gonzàlez Cabrera, Diego, Nchinda, Aloysius T., de Kock, Carmen, Wiesner, Lubbe, Denti, Paolo, Waterson, David, Blasco, Benjamin, Leroy, Didier, Witty, Michael J., Donini, Cristina, Duffy, James, Wittlin, Sergio, White, Karen L., Charman, Susan A., Jiménez-Díaz, Maria Belén, Angulo-Barturen, Iñigo, Herreros, Esperanza, Gamo, Francisco Javier, Rochford, Rosemary, Mancama, Dalu, Coetzer, Theresa L., van der Watt, Mariëtte E., Reader, Janette, Birkholtz, Lyn-Marie, Marsh, Kennan C., Solapure, Suresh M., Burke, John E., McPhail, Jacob A., Vanaerschot, Manu, Fidock, David A., Fish, Paul V., Siegl, Peter, Smith, Dennis A., Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N., Marfurt, Jutta, Silue, Kigbafori D., Street, Leslie J., and Chibale, Kelly

Published
2018
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10. UCT943, a Next-Generation Plasmodium falciparumPI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

Author

Brunschwig, Christel, Lawrence, Nina, Taylor, Dale, Abay, Efrem, Njoroge, Mathew, Basarab, Gregory S., Le Manach, Claire, Paquet, Tanya, Cabrera, Diego Gonzàlez, Nchinda, Aloysius T., de Kock, Carmen, Wiesner, Lubbe, Denti, Paolo, Waterson, David, Blasco, Benjamin, Leroy, Didier, Witty, Michael J., Donini, Cristina, Duffy, James, Wittlin, Sergio, White, Karen L., Charman, Susan A., Jiménez-Díaz, Maria Belén, Angulo-Barturen, Iñigo, Herreros, Esperanza, Gamo, Francisco Javier, Rochford, Rosemary, Mancama, Dalu, Coetzer, Theresa L., van der Watt, Mariëtte E., Reader, Janette, Birkholtz, Lyn-Marie, Marsh, Kennan C., Solapure, Suresh M., Burke, John E., McPhail, Jacob A., Vanaerschot, Manu, Fidock, David A., Fish, Paul V., Siegl, Peter, Smith, Dennis A., Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N., Marfurt, Jutta, Silue, Kigbafori D., Street, Leslie J., and Chibale, Kelly

Abstract

The 2-aminopyridine MMV048 was the first drug candidate inhibiting Plasmodiumphosphatidylinositol 4-kinase (PI4K), a novel drug target for malaria, to enter clinical development. In an effort to identify the next generation of PI4K inhibitors, the series was optimized to improve properties such as solubility and antiplasmodial potency across the parasite life cycle, leading to the 2-aminopyrazine UCT943.

Published
2018
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11. High Sensitivity of Mobile Phone Microscopy Screening for Schistosoma haematobium in Azaguié, Côte d'Ivoire.

Author

Coulibaly JT, Silue KD, Armstrong M, Díaz de León Derby M, D'Ambrosio MV, Fletcher DA, Keiser J, Fisher K, Andrews JR, and Bogoch II

Subjects
Humans, Animals, Schistosoma haematobium, Microscopy, Cote d'Ivoire epidemiology, Schistosomiasis diagnosis, Cell Phone
Abstract

Schistosomiasis infections continue to impact African settings disproportionately, and there is an urgent need for novel tools to evaluate infection control and elimination strategies at the community level. Mobile phone microscopes are portable and semiautomated devices with multiple applications for screening neglected tropical diseases. In a community-based schistosomiasis screening program in Azaguié, Côte d'Ivoire, mobile phone microscopy demonstrated a sensitivity of 85.7% (95% CI: 69.7-95.2%) and specificity of 93.3% (95% CI: 87.7-96.9%) for Schistosoma haematobium identification compared with conventional light microscopy, and 95% sensitivity (95% CI: 74.1-99.8%) with egg concentrations of five or more per 10 mL of urine. Mobile phone microscopy is a promising tool for schistosomiasis control and elimination efforts.

Published
2022
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