Search

Your search keyword '"Silsby, Matthew"' showing total 41 results
Start Over Author "Silsby, Matthew"
41 results on '"Silsby, Matthew"'

3. Unilateral Upper‐Limb Tremor Due to C6 Radiculopathy and Demyelinating Neuropathy.

Author

Nagaratnam, Sai A., Harinesan, Nimalan, Silsby, Matthew, and Fung, Victor S.C.

Subjects
CHRONIC inflammatory demyelinating polyradiculoneuropathy, NERVE conduction studies, MOTOR unit, MOTOR neuron diseases, MAGNETIC resonance imaging, POLYNEUROPATHIES
Abstract

The article in "Movement Disorders Clinical Practice" discusses a case of a 49-year-old man with unilateral upper-limb tremor linked to C6 radiculopathy and demyelinating neuropathy. The patient experienced left-arm tremors triggered by elbow flexion, along with sensory symptoms in the feet. Treatment with onabotulinumtoxinA improved the tremor significantly. The study suggests that the tremor's origin was peripheral due to C6 nerve root pathology and coexistent multifocal acquired demyelinating sensory and motor neuropathy (MADSAM). [Extracted from the article]

Published
2024
Full Text
View/download PDF

16. Autoantibodies, routine and novel markers of neuroinflammation in people with atypical psychiatric disease

Author

Jiang, Jocelyn X, primary, Fewings, Nicole, additional, Gatt, Prudence, additional, Dervish, Suat, additional, Silsby, Matthew, additional, Fois, Alessandro F, additional, Duma, Stephen, additional, Bandodkar, Sushil, additional, Ramanathan, Sudarshini, additional, Bleasel, Andrew, additional, John, Bryne, additional, Harris, Anthony, additional, Lin, Ming-Wei, additional, and Brown, David, additional

Published
2023
Full Text
View/download PDF

25. TDP-43 proteinopathies: a new wave of neurodegenerative diseases

Author

Projectafdeling ALS, ZL Neuromusculaire Ziekten Medisch, Brain, Regenerative Medicine and Stem Cells, de Boer, Eva Maria Johanna, Orie, Viyanti K, Williams, Timothy, Baker, Mark R, Oliviera, Hugo, Polvikoski, Tuomo, Silsby, Matthew, Menon, Parvathi, van den Bos, Mehdi, Halliday, Glenda M, van den Berg, Leonard H, Van Den Bosch, Ludo, van Damme, Philip, Kiernan, Matthew, van Es, Michael A, Vucic, Steve, Projectafdeling ALS, ZL Neuromusculaire Ziekten Medisch, Brain, Regenerative Medicine and Stem Cells, de Boer, Eva Maria Johanna, Orie, Viyanti K, Williams, Timothy, Baker, Mark R, Oliviera, Hugo, Polvikoski, Tuomo, Silsby, Matthew, Menon, Parvathi, van den Bos, Mehdi, Halliday, Glenda M, van den Berg, Leonard H, Van Den Bosch, Ludo, van Damme, Philip, Kiernan, Matthew, van Es, Michael A, and Vucic, Steve

Published
2021

26. TDP-43 proteinopathies: a new wave of neurodegenerative diseases

Author

de Boer, Eva Maria Johanna, primary, Orie, Viyanti K, additional, Williams, Timothy, additional, Baker, Mark R, additional, De Oliveira, Hugo M, additional, Polvikoski, Tuomo, additional, Silsby, Matthew, additional, Menon, Parvathi, additional, van den Bos, Mehdi, additional, Halliday, Glenda M, additional, van den Berg, Leonard H, additional, Van Den Bosch, Ludo, additional, van Damme, Philip, additional, Kiernan, Matthew C, additional, van Es, Michael A, additional, and Vucic, Steve, additional

Published
2020
Full Text
View/download PDF

29. Novel Surrogate Markers of CNS Inflammation in CSF in the Diagnosis of Autoimmune Encephalitis

Author

Jiang, Jocelyn X., primary, Fewings, Nicole, additional, Dervish, Suat, additional, Fois, Alessandro F., additional, Duma, Stephen R., additional, Silsby, Matthew, additional, Bandodkar, Sushil, additional, Ramanathan, Sudarshini, additional, Bleasel, Andrew, additional, John, Bryne, additional, Brown, David A., additional, and Lin, Ming-Wei, additional

Published
2020
Full Text
View/download PDF

30. Posturography as a biomarker of intravenous immunoglobulin efficacy in chronic inflammatory demyelinating polyradiculoneuropathy.

Author

Silsby, Matthew, Yiannikas, Con, Ng, Karl, Kiernan, Matthew C., Fung, Victor S. C., and Vucic, Steve

Abstract

Introduction/Aims: Imbalance is a common feature of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Intravenous immunoglobulin (IVIg) exerts clinical benefit in CIDP, including improving balance, although objective markers of efficacy are lacking. Posturography is an established objective marker of balance; therefore, this study aimed to determine the utility of posturography as an objective marker of treatment efficacy in CIDP. Methods: Posturography was performed on 18 CIDP patients, established on IVIg infusions, and results were compared to age‐matched healthy controls. CIDP patients were assessed just prior to IVIg infusion and at the mid‐point of the cycle. Center of pressure (CoP) was measured and the total path traveled by CoP (Sway Path, SP) was calculated for five different conditions: feet placed in parallel 16 cm apart at the medial border with eyes open (16cmEO) and eyes closed (16cmEC); medial borders of the feet touching with eyes open (0cmEO) and eyes closed (0cmEC); and tandem stance. Results: The sway path (SP) was significantly increased in CIDP patients (mean SP 1191 ± 104 mm) when compared to healthy controls (mean SP 724 ± 26 mm, P <.001). The increase was most prominent during eyes closed and tandem stance conditions. Treatment with IVIg significantly reduced SP when assessing 0cmEC (1759 ± 324 mm vs. 1081 ± 134 mm, P =.019) and tandem stance (1775 ± 290 mm vs. 1152 ± 113 mm, P =.027). Discussion Posturography detected significant improvements in balance following IVIg in CIDP patients established on maintenance therapy. As such, posturography may be considered an objective marker of treatment response in clinical management and therapeutic trials. See Editorial on pages 7‐9 in this issue. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

33. TDP-43 proteinopathies: a new wave of neurodegenerative diseases.

Author

Johanna de Boer, Eva Maria, Orie, Viyanti K., Williams, Timothy, Baker, Mark R., De Oliveira, Hugo M., Tuomo Polvikoski, Silsby, Matthew, Menon, Parvathi, van den Bos, Mehdi, Halliday, Glenda M., van den Berg, Leonard H., Van Den Bosch, Ludo, van Damme, Philip, Kiernan, Matthew, van Es, Michael A., Vucic, Steve, de Boer, Eva Maria Johanna, Polvikoski, Tuomo, and Kiernan, Matthew C

Subjects
FRONTOTEMPORAL lobar degeneration, TDP-43 proteinopathies, NEURODEGENERATION, MOTOR neuron diseases, RNA-binding proteins, PATHOLOGY
Abstract

Inclusions of pathogenic deposits containing TAR DNA-binding protein 43 (TDP-43) are evident in the brain and spinal cord of patients that present across a spectrum of neurodegenerative diseases. For instance, the majority of patients with sporadic amyotrophic lateral sclerosis (up to 97%) and a substantial proportion of patients with frontotemporal lobar degeneration (~45%) exhibit TDP-43 positive neuronal inclusions, suggesting a role for this protein in disease pathogenesis. In addition, TDP-43 inclusions are evident in familial ALS phenotypes linked to multiple gene mutations including the TDP-43 gene coding (TARDBP) and unrelated genes (eg, C9orf72). While TDP-43 is an essential RNA/DNA binding protein critical for RNA-related metabolism, determining the pathophysiological mechanisms through which TDP-43 mediates neurodegeneration appears complex, and unravelling these molecular processes seems critical for the development of effective therapies. This review highlights the key physiological functions of the TDP-43 protein, while considering an expanding spectrum of neurodegenerative diseases associated with pathogenic TDP-43 deposition, and dissecting key molecular pathways through which TDP-43 may mediate neurodegeneration. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

34. Potential surrogate markers of central nervous system inflammation in cerebrospinal fluid in the diagnosis of autoimmune encephalitis

Author

Brown, David A., primary, Jiang, Jocelyn, additional, Ramanathan, Sudarshini, additional, Silvestrini, Roger, additional, Bleasel, Andrew, additional, Wienholt, Louise, additional, Fewings, Nicole, additional, Dumas, Steven, additional, Silsby, Matthew, additional, Yin, Katie, additional, Fois, Alex, additional, and Lin, Ming-Wei, additional

Published
2018
Full Text
View/download PDF

38. Potential surrogate markers of central nervous system inflammation in cerebrospinal fluid in the diagnosis of autoimmune encephalitis

Author

Jiang, Jocelyn X., primary, Ramanathan, Sudarshini, additional, Silvestrini, Roger, additional, Bleasel, Andrew, additional, Wienholt, Louise, additional, Fewings, Nicole, additional, Duma, Stephen, additional, Silsby, Matthew, additional, Yin, Katie, additional, Fois, Alessandro F., additional, Brown, David A., additional, and Lin, Ming-Wei, additional

Published
2018
Full Text
View/download PDF

39. TDP-43 proteinopathies: a new wave of neurodegenerative diseases

Author

de Boer, Eva Maria Johanna, Orie, Viyanti K, Williams, Timothy, Baker, Mark R, De Oliveira, Hugo M, Polvikoski, Tuomo, Silsby, Matthew, Menon, Parvathi, van den Bos, Mehdi, Halliday, Glenda M, van den Berg, Leonard H, Van Den Bosch, Ludo, van Damme, Philip, Kiernan, Matthew, van Es, Michael A, and Vucic, Steve

Abstract

Inclusions of pathogenic deposits containing TAR DNA-binding protein 43 (TDP-43) are evident in the brain and spinal cord of patients that present across a spectrum of neurodegenerative diseases. For instance, the majority of patients with sporadic amyotrophic lateral sclerosis (up to 97%) and a substantial proportion of patients with frontotemporal lobar degeneration (~45%) exhibit TDP-43 positive neuronal inclusions, suggesting a role for this protein in disease pathogenesis. In addition, TDP-43 inclusions are evident in familial ALS phenotypes linked to multiple gene mutations including the TDP-43 gene coding (TARDBP) and unrelated genes (eg, C9orf72). While TDP-43 is an essential RNA/DNA binding protein critical for RNA-related metabolism, determining the pathophysiological mechanisms through which TDP-43 mediates neurodegeneration appears complex, and unravelling these molecular processes seems critical for the development of effective therapies. This review highlights the key physiological functions of the TDP-43 protein, while considering an expanding spectrum of neurodegenerative diseases associated with pathogenic TDP-43 deposition, and dissecting key molecular pathways through which TDP-43 may mediate neurodegeneration.

Published
2021
Full Text
View/download PDF

40. Proximal Median Neuropathy Following Anterior Shoulder Dislocation: The Use of Magnetic Resonance Neurography

Author

Silsby, Matthew, Robertson, Alasdair, and Yiannikas, Con

Abstract

Proximal median nerve injury is an uncommon consequence of anterior shoulder dislocation, especially occurring in isolation of other upper limb peripheral nerve injury. We report the case of an 82-year-old woman with a median nerve injury as detected by clinical and neurophysiological examination following a fall and anterior shoulder dislocation. Magnetic resonance neurography confirmed the diagnosis, but also detected asymptomatic brachial plexus and ulnar nerve involvement. Management was non-operative and there has been some improvement over several months. Our case expands the differential diagnosis for proximal median neuropathy and discusses the utility of neurography in cases of neural injury.

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results