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Background: Squamous cell carcinoma is the second most common non-melanoma skin cancer, thought to be related to sun exposure1. The treatment usually involves surgical excision, resulting defects that need reconstruction for significant aesthetic and functional implications. Objective: Our aim is to highlight the effectiveness of the surgical treatment for squamous cells carcinoma in the face region. Material and methods: We report the case of a 69-year-old male who presented with a seven months history of ulcerative, whitish cutaneous lesion with elevated margins in the right parotideomasseteric region. Due to the high-risk location, the progressively increasing size and the characteristic aspect, the lesion was surgically excised with clear margins and the reconstruction has been done using a loco-regional skin flap from the cervical region. Results: The histopathological diagnosis was of squamous cell carcinoma, poorly differentiated (G3), with an anatomical invasion which corresponds to Clark level IV (invading into the reticular dermis) and a Breslow index of 4 mm. The tumoral fragment showed a central necrotic area and an underlying proliferation of tumor cells, free resection margins and an adjacent epidermis with actinic keratosis. No tumor emboli or perineural invasion was observed. Immunohistochemistry was EMA positive and CEA and HMB45 negative. Post-surgery, the patient had not undergone chemotherapy nor radiotherapy, but he is still on regular follow up at an interval of one month without any evidence of disease recurrence. Conclusion: Surgery is the primary means of treatment for the pathology presented1. Considering the location, the surgery can lead to a significant psychological effect but, with a vast experience of the surgeon, it can result in a very good-looking cosmetic outcome. [ABSTRACT FROM AUTHOR]