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1. Histopathological grading affects survival in patients with IDH-mutant grade II and grade III diffuse gliomas

Author

Franceschi, Enrico, Tosoni, Alicia, Bartolini, Stefania, Minichillo, Santino, Mura, Antonella, Asioli, Sofia, Bartolini, Daniela, Gardiman, Marina, Gessi, Marco, Ghimenton, Claudio, Giangaspero, Felice, Lanza, Giovanni, Marucci, Gianluca, Novello, Mariangela, Silini, Enrico M., Zunarelli, Elena, Paccapelo, Alexandro, and Brandes, Alba A.

Published
2020
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3. Sentinel European Node Trial (SENT): 3-year results of sentinel node biopsy in oral cancer

Author

Schilling, Clare, Stoeckli, Sandro J., Haerle, Stephan K., Broglie, Martina A., Huber, Gerhard F., Sorensen, Jens Ahm, Bakholdt, Vivi, Krogdahl, Annelise, von Buchwald, Christian, Bilde, Anders, Sebbesen, Lars R., Odell, Edward, Gurney, Benjamin, O'Doherty, Michael, de Bree, Remco, Bloemena, Elisabeth, Flach, Geke B., Villarreal, Pedro M., Fresno Forcelledo, Manuel Florentino, Junquera Gutiérrez, Luis Manuel, Amézaga, Julio Alvarez, Barbier, Luis, Santamaría-Zuazua, Joseba, Moreira, Augusto, Jacome, Manuel, Vigili, Maurizio Giovanni, Rahimi, Siavash, Tartaglione, Girolamo, Lawson, Georges, Nollevaux, Marie-Cecile, Grandi, Cesare, Donner, Davide, Bragantini, Emma, Dequanter, Didier, Lothaire, Philippe, Poli, Tito, Silini, Enrico M., Sesenna, Erinco, Dolivet, Giles, Mastronicola, Romina, Leroux, Agnes, Sassoon, Isabel, Sloan, Philip, and McGurk, Mark

Published
2015
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5. Implications of a positive sentinel node in oral squamous cell carcinoma

Author

Gurney, Benjamin A. S., Schilling, Clare, Putcha, Venkata, Alkureishi, Lee W., Alvarez, Amezaga J., Bakholdt, Vivi, Barbier Herrero, Luis, Barzan, Luigi, Bilde, Anders, Bloemena, Elisabeth, Salces, Carmen Camarero, Palma, Paolo Dalla, de Bree, Remco, Dequanter, Didier, Dolivet, Gilles, Donner, Davide, Flach, Geke B., Fresno, Manuel, Grandi, Cesare, Haerle, Stephan, Huber, Gerhard F., Hunter, Keith, Lawson, George, Leroux, Agnes, Lothaire, Phillippe H., Mamelle, Gerard, Silini, Enrico M., Mastronicola, Romina, Odell, Edward W., OʼDoherty, Michael J., Poli, Tito, Rahimi, Siavash, Ross, Gary L., Zuazua, Santamaria J., Santini, Simone, Sebbesen, Lars, Shoaib, Taimur, Sloan, Philip, Sorensen, Jens Ahm, Soutar, David S., Therkildsen, Marianne H., Vigili, Maurizio Giovanni, Villarreal, Pedro M., von Buchwald, Christian, Werner, Jochen A., Wiegand, Susanne, and McGurk, Mark

Published
2012
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6. Vascular liver injury mimicking an intrahepatic cholangiocarcinoma in a COVID‐19 patient

Author

Ugolotti, Maria C., primary, Pedrazzini, Massimo, additional, Silini, Enrico M., additional, Missale, Gabriele, additional, Silva, Mario, additional, Franzini, Christian, additional, Palmieri, Gerardo, additional, Costi, Renato, additional, Montali, Filippo, additional, Gnappi, Elisa, additional, Terroni, Lorenza, additional, Colizzi, Elena, additional, Meschi, Michele, additional, and Facchinetti, Francesco, additional

Published
2021
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9. Abstract P1-18-19: Phase II, open label, randomized, biomarker study of immune-mediated mechanism of action of neoadjuvant subcutaneous trastuzumab in patients with operable, locally advanced, or inflammatory HER2-positive breast cancer. ImmunHER trial on behalf of the Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC)

Author

Musolino, Antonino, primary, Gori, Stefania, additional, Cretella, Elisabetta, additional, Marabese, Alessandra, additional, Cavanna, Luigi, additional, Frassoldati, Antonio, additional, Bisagni, Giancarlo, additional, Casarini, Chiara, additional, Bria, Emilio, additional, Carbognin, Luisa, additional, Fiorio, Elena, additional, Brandes, Alba A, additional, Zamagni, Claudio, additional, Gianni, Lorenzo, additional, Zambelli, Alberto, additional, Montemurro, Filippo, additional, Tognetto, Michele, additional, Todeschini, Renata, additional, Maglietta, Giuseppe, additional, Missale, Gabriele, additional, and Silini, Enrico M, additional

Published
2020
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10. Extragenital Müllerian adenosarcoma with pouch of Douglas location

Author

Thai Elena, Franchi Laura, Berretta Roberto, Gizzo Salvatore, Silini Enrico M, Patrelli Tito S, Lukanovic Adolf, Nardelli Giovanni B, and Modena Alberto

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Of all female genital tract tumors, 1-3% are stromal malignancies. In 8-10% of cases, these are represented by Müllerian adenosarcoma an extremely rare tumor characterized by a stromal component of usually low-grade malignancy and by a benign glandular epithelial component. Variant that arises in the pouch of Douglas is scarcely mentioned in the medical literature. Case Presentation A 49-year-old para-0 woman, was seen at our OB/GYN-UNIT because she complained vaguely of pelvic pain. She had a mass of undefined nature in the pouch of Douglas. A simple excision of the mass showed low-grade Müllerian adenosarcoma with areas of stromal overgrowth. One and a half year after surgery, at another hospital, a mass was detected in the patient's posterior vaginal fornix and removed surgically. Six months later she came back to our observation with vaginal bleeding and mass in the vaginal fornix. We performed radical surgery. The pathological examination showed recurrent adenosarcoma. Surgical treatment was supplemented by radiation therapy. Conclusions The case of Müllerian adenosarcoma reported here is the third known so far in the literature that was located in the pouch of Douglas. To date, only two other such cases have been reported, including one resulting from neoplastic degeneration of an endometriotic cyst.

Published
2011
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12. Immune context characterization and heterogeneity in primary tumors and pulmonary metastases from renal cell carcinoma

Author

Bersanelli, Melissa, primary, Gnetti, Letizia, additional, Varotti, Elena, additional, Ampollini, Luca, additional, Carbognani, Paolo, additional, Leonardi, Francesco, additional, Rusca, Michele, additional, Campanini, Nicoletta, additional, Ziglioli, Francesco, additional, Dadomo, Clara I, additional, Pilato, Francesco P, additional, Cortellini, Alessio, additional, Rapacchi, Elena, additional, Caruso, Giuseppe, additional, Silini, Enrico M, additional, Maestroni, Umberto, additional, and Buti, Sebastiano, additional

Published
2019
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13. Prognostic modeling of oral cancer by gene profiles and clinicopathological co-variables

Author

Mes, Steven W., primary, te Beest, Dennis, additional, Poli, Tito, additional, Rossi, Silvia, additional, Scheckenbach, Kathrin, additional, van Wieringen, Wessel N., additional, Brink, Arjen, additional, Bertani, Nicoletta, additional, Lanfranco, Davide, additional, Silini, Enrico M., additional, van Diest, Paul J., additional, Bloemena, Elisabeth, additional, Leemans, C. René, additional, van de Wiel, Mark A., additional, and Brakenhoff, Ruud H., additional

Published
2017
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14. Prognostic modeling of oral cancer by gene profiles and clinicopathological co-variables

Author

Mes, Steven W., te Beest, Dennis, Poli, Tito, Rossi, Silvia, Scheckenbach, Kathrin, Van Wieringen, Wessel N., Brink, Arjen, Bertani, Nicoletta, Lanfranco, Davide, Silini, Enrico M., van Diest, Paul J., Bloemena, Elisabeth, René Leemans, C., Van De Wiel, Mark A., Brakenhoff, Ruud H, Mes, Steven W., te Beest, Dennis, Poli, Tito, Rossi, Silvia, Scheckenbach, Kathrin, Van Wieringen, Wessel N., Brink, Arjen, Bertani, Nicoletta, Lanfranco, Davide, Silini, Enrico M., van Diest, Paul J., Bloemena, Elisabeth, René Leemans, C., Van De Wiel, Mark A., and Brakenhoff, Ruud H

Published
2017

15. Prognostic modeling of oral cancer by gene profiles and clinicopathological co-variables

Author

Pathologie mortuarium en obductie, UMC Utrecht, Pathologie, Cancer, Mes, Steven W., te Beest, Dennis, Poli, Tito, Rossi, Silvia, Scheckenbach, Kathrin, Van Wieringen, Wessel N., Brink, Arjen, Bertani, Nicoletta, Lanfranco, Davide, Silini, Enrico M., van Diest, Paul J., Bloemena, Elisabeth, René Leemans, C., Van De Wiel, Mark A., Brakenhoff, Ruud H, Pathologie mortuarium en obductie, UMC Utrecht, Pathologie, Cancer, Mes, Steven W., te Beest, Dennis, Poli, Tito, Rossi, Silvia, Scheckenbach, Kathrin, Van Wieringen, Wessel N., Brink, Arjen, Bertani, Nicoletta, Lanfranco, Davide, Silini, Enrico M., van Diest, Paul J., Bloemena, Elisabeth, René Leemans, C., Van De Wiel, Mark A., and Brakenhoff, Ruud H

Published
2017

16. Hepatitis C Virus Genotypes and Risk of Cirrhosis in Southern Italy

Author

Osella, Alberto R., Misciagna, Giovanni, Guerra, Vito, Elba, Silvana, Buongiorno, Giampiero, Cavallini, Aldo, Leo, Alfredo Di, Sonzogni, Laura, Mondelli, Mario U., and Silini, Enrico M.

Subjects
Hepatitis C virus -- Health aspects, Liver cirrhosis -- Causes of, Health, Health care industry
Published
2001

17. Sentinel Node in Oral Cancer: The Nuclear Medicine Aspects. A Survey from the Sentinel European Node Trial.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/CARS - Computer Assisted Robotic Surgery, UCL - (MGD) Service d'oto-rhino-laryngologie, UCL - SSS/IREC/MORF - Pôle de Morphologie, UCL - (MGD) Service d'anatomie pathologique, Tartaglione, Girolamo, Stoeckli, Sandro J, de Bree, Remco, Schilling, Clare, Flach, Geke B, Bakholdt, Vivi, Sorensen, Jens Ahm, Bilde, Anders, von Buchwald, Christian, Lawson, Georges, Dequanter, Didier, Villarreal, Pedro M, Forcelledo, Manuel Florentino Fresno, Amezaga, Julio Alvarez, Moreira, Augusto, Poli, Tito, Grandi, Cesare, Vigili, Maurizio Giovanni, O'Doherty, Michael, Donner, Davide, Bloemena, Elisabeth, Rahimi, Siavash, Gurney, Benjamin, Haerle, Stephan K, Broglie, Martina A, Huber, Gerhard F, Krogdah, Annelise L, Sebbesen, Lars R, Odell, Edward, Junquera Gutierrez, Luis Manuel, Barbier, Luis, Santamaria-Zuazua, Joseba, Jacome, Manuel, Nollevaux, Marie-Cécile, Bragantini, Emma, Lothaire, Philippe, Silini, Enrico M, Sesenna, Enrico, Dolivet, Giles, Mastronicola, Romina, Leroux, Agnes, Sassoon, Isabel, Sloan, Philip, Colletti, Patrick M, Rubello, Domenico, McGurk, Mark, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/CARS - Computer Assisted Robotic Surgery, UCL - (MGD) Service d'oto-rhino-laryngologie, UCL - SSS/IREC/MORF - Pôle de Morphologie, UCL - (MGD) Service d'anatomie pathologique, Tartaglione, Girolamo, Stoeckli, Sandro J, de Bree, Remco, Schilling, Clare, Flach, Geke B, Bakholdt, Vivi, Sorensen, Jens Ahm, Bilde, Anders, von Buchwald, Christian, Lawson, Georges, Dequanter, Didier, Villarreal, Pedro M, Forcelledo, Manuel Florentino Fresno, Amezaga, Julio Alvarez, Moreira, Augusto, Poli, Tito, Grandi, Cesare, Vigili, Maurizio Giovanni, O'Doherty, Michael, Donner, Davide, Bloemena, Elisabeth, Rahimi, Siavash, Gurney, Benjamin, Haerle, Stephan K, Broglie, Martina A, Huber, Gerhard F, Krogdah, Annelise L, Sebbesen, Lars R, Odell, Edward, Junquera Gutierrez, Luis Manuel, Barbier, Luis, Santamaria-Zuazua, Joseba, Jacome, Manuel, Nollevaux, Marie-Cécile, Bragantini, Emma, Lothaire, Philippe, Silini, Enrico M, Sesenna, Enrico, Dolivet, Giles, Mastronicola, Romina, Leroux, Agnes, Sassoon, Isabel, Sloan, Philip, Colletti, Patrick M, Rubello, Domenico, and McGurk, Mark

Abstract

PURPOSE: Nuclear imaging plays a crucial role in lymphatic mapping of oral cancer. This evaluation represents a subanalysis of the original multicenter SENT trial data set, involving 434 patients with T1-T2, N0, and M0 oral squamous cell carcinoma. The impact of acquisition techniques, tracer injection timing relative to surgery, and causes of false-negative rate were assessed. METHODS: Three to 24 hours before surgery, all patients received a dose of Tc-nanocolloid (10-175 MBq), followed by lymphoscintigraphy. According to institutional protocols, all patients underwent preoperative dynamic/static scan and/or SPECT/CT. RESULTS: Lymphoscintigraphy identified 723 lymphatic basins. 1398 sentinel lymph nodes (SNs) were biopsied (3.2 SN per patient; range, 1-10). Dynamic scan allowed the differentiation of sentinel nodes from second tier lymph nodes. SPECT/CT allowed more accurate anatomical localization and estimated SN depth more efficiently. After pathological examination, 9.9% of the SN excised (138 of 1398 SNs) showed metastases. The first neck level (NL) containing SN+ was NL I in 28.6%, NL IIa in 44.8%, NL IIb in 2.8%, NL III in 17.1%, and NL IV in 6.7% of positive patients. Approximately 96% of positive SNs were localized in the first and second lymphatic basin visualized using lymphoscintigraphy. After neck dissection, the SN+ was the only lymph node containing metastasis in approximately 80% of patients. CONCLUSIONS: Best results were observed using a dynamic scan in combination with SPECT/CT. A shorter interval between tracer injection, imaging, and surgery resulted in a lower false-negative rate. At least 2 NLs have to be harvested, as this may increase the detection of lymphatic metastases.

Published
2016

18. Sentinel Node in Oral Cancer:The Nuclear Medicine Aspects. A Survey from the Sentinel European Node Trial

Author

Tartaglione, Girolamo, Stoeckli, Sandro J, de Bree, Remco, Schilling, Clare, Flach, Geke B, Bakholdt, Vivi T., Sorensen, Jens Ahm, Bilde, Anders, von Buchwald, Christian, Lawson, Georges, Dequanter, Didier, Villarreal, Pedro M, Forcelledo, Manuel Florentino Fresno, Amézaga, Julio Alvarez, Moreira, Augusto, Poli, Tito, Grandi, Cesare, Vigili, Maurizio Giovanni, O'Doherty, Michael J, Donner, Davide, Bloemena, Elisabeth, Rahimi, Siavash, Gurney, Benjamin A S, Haerle, Stephan K, Broglie, Martina A, Huber, Gerhard F, Krogdah, Annelise L, Sebbesen, Lars R, Odell, Edward, Junquera Gutiérrez, Luis Manuel, Barbier Herrero, Luis, Santamaría-Zuazua, Joseba, Jacome, Manuel, Nollevaux, Marie-Cecile, Bragantini, Emma, Lothaire, Philippe, Silini, Enrico M, Sesenna, Enrico, Dolivet, Giles, Mastronicola, Romina, Leroux, Agnes, Sassoon, Isabel, Sloan, Philip, Colletti, Patrick M, Rubello, Domenico, McGurk, Mark, Tartaglione, Girolamo, Stoeckli, Sandro J, de Bree, Remco, Schilling, Clare, Flach, Geke B, Bakholdt, Vivi T., Sorensen, Jens Ahm, Bilde, Anders, von Buchwald, Christian, Lawson, Georges, Dequanter, Didier, Villarreal, Pedro M, Forcelledo, Manuel Florentino Fresno, Amézaga, Julio Alvarez, Moreira, Augusto, Poli, Tito, Grandi, Cesare, Vigili, Maurizio Giovanni, O'Doherty, Michael J, Donner, Davide, Bloemena, Elisabeth, Rahimi, Siavash, Gurney, Benjamin A S, Haerle, Stephan K, Broglie, Martina A, Huber, Gerhard F, Krogdah, Annelise L, Sebbesen, Lars R, Odell, Edward, Junquera Gutiérrez, Luis Manuel, Barbier Herrero, Luis, Santamaría-Zuazua, Joseba, Jacome, Manuel, Nollevaux, Marie-Cecile, Bragantini, Emma, Lothaire, Philippe, Silini, Enrico M, Sesenna, Enrico, Dolivet, Giles, Mastronicola, Romina, Leroux, Agnes, Sassoon, Isabel, Sloan, Philip, Colletti, Patrick M, Rubello, Domenico, and McGurk, Mark

Abstract

PURPOSE: Nuclear imaging plays a crucial role in lymphatic mapping of oral cancer. This evaluation represents a subanalysis of the original multicenter SENT trial data set, involving 434 patients with T1-T2, N0, and M0 oral squamous cell carcinoma. The impact of acquisition techniques, tracer injection timing relative to surgery, and causes of false-negative rate were assessed.METHODS: Three to 24 hours before surgery, all patients received a dose of Tc-nanocolloid (10-175 MBq), followed by lymphoscintigraphy. According to institutional protocols, all patients underwent preoperative dynamic/static scan and/or SPECT/CT.RESULTS: Lymphoscintigraphy identified 723 lymphatic basins. 1398 sentinel lymph nodes (SNs) were biopsied (3.2 SN per patient; range, 1-10). Dynamic scan allowed the differentiation of sentinel nodes from second tier lymph nodes. SPECT/CT allowed more accurate anatomical localization and estimated SN depth more efficiently. After pathological examination, 9.9% of the SN excised (138 of 1398 SNs) showed metastases. The first neck level (NL) containing SN+ was NL I in 28.6%, NL IIa in 44.8%, NL IIb in 2.8%, NL III in 17.1%, and NL IV in 6.7% of positive patients. Approximately 96% of positive SNs were localized in the first and second lymphatic basin visualized using lymphoscintigraphy. After neck dissection, the SN+ was the only lymph node containing metastasis in approximately 80% of patients.CONCLUSIONS: Best results were observed using a dynamic scan in combination with SPECT/CT. A shorter interval between tracer injection, imaging, and surgery resulted in a lower false-negative rate. At least 2 NLs have to be harvested, as this may increase the detection of lymphatic metastases.

Published
2016

19. Sentinel Node in Oral Cancer

Author

Tartaglione, Girolamo, primary, Stoeckli, Sandro J., additional, de Bree, Remco, additional, Schilling, Clare, additional, Flach, Geke B., additional, Bakholdt, Vivi, additional, Sorensen, Jens Ahm, additional, Bilde, Anders, additional, von Buchwald, Christian, additional, Lawson, Georges, additional, Dequanter, Didier, additional, Villarreal, Pedro M., additional, Forcelledo, Manuel Florentino Fresno, additional, Amezaga, Julio Alvarez, additional, Moreira, Augusto, additional, Poli, Tito, additional, Grandi, Cesare, additional, Vigili, Maurizio Giovanni, additional, O’Doherty, Michael, additional, Donner, Davide, additional, Bloemena, Elisabeth, additional, Rahimi, Siavash, additional, Gurney, Benjamin, additional, Haerle, Stephan K., additional, Broglie, Martina A., additional, Huber, Gerhard F., additional, Krogdah, Annelise l., additional, Sebbesen, Lars R., additional, Odell, Edward, additional, Junquera Gutierrez, Luis Manuel, additional, Barbier, Luis, additional, Santamaria-Zuazua, Joseba, additional, Jacome, Manuel, additional, Nollevaux, Marie-Cecile, additional, Bragantini, Emma, additional, Lothaire, Philippe, additional, Silini, Enrico M., additional, Sesenna, Enrico, additional, Dolivet, Giles, additional, Mastronicola, Romina, additional, Leroux, Agnes, additional, Sassoon, Isabel, additional, Sloan, Philip, additional, Colletti, Patrick M., additional, Rubello, Domenico, additional, and McGurk, Mark, additional

Published
2016
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21. Sentinel European Node Trial (SENT): 3-year results of sentinel node biopsy in oral cancer.

Author

UCL - SSS/IREC/MORF - Pôle de Morphologie, UCL - (MGD) Service d'anatomie pathologique, UCL - (MGD) Service d'oto-rhino-laryngologie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/CARS - Computer Assisted Robotic Surgery, Schilling, Clare, Stoeckli, Sandro J, Haerle, Stephan K, Broglie, Martina A, Huber, Gerhard F, Sorensen, Jens Ahm, Bakholdt, Vivi, Krogdahl, Annelise, von Buchwald, Christian, Bilde, Anders, Sebbesen, Lars R, Odell, Edward, Gurney, Benjamin, O'Doherty, Michael, de Bree, Remco, Bloemena, Elisabeth, Flach, Geke B, Villarreal, Pedro M, Fresno Forcelledo, Manuel Florentino, Junquera Gutiérrez, Luis Manuel, Amézaga, Julio Alvarez, Barbier, Luis, Santamaría-Zuazua, Joseba, Moreira, Augusto, Jacome, Manuel, Vigili, Maurizio Giovanni, Rahimi, Siavash, Tartaglione, Girolamo, Lawson, Georges, Nollevaux, Marie-Cécile, Grandi, Cesare, Donner, Davide, Bragantini, Emma, Dequanter, Didier, Lothaire, Philippe, Poli, Tito, Silini, Enrico M, Sesenna, Erinco, Dolivet, Giles, Mastronicola, Romina, Leroux, Agnes, Sassoon, Isabel, Sloan, Philip, McGurk, Mark, UCL - SSS/IREC/MORF - Pôle de Morphologie, UCL - (MGD) Service d'anatomie pathologique, UCL - (MGD) Service d'oto-rhino-laryngologie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/CARS - Computer Assisted Robotic Surgery, Schilling, Clare, Stoeckli, Sandro J, Haerle, Stephan K, Broglie, Martina A, Huber, Gerhard F, Sorensen, Jens Ahm, Bakholdt, Vivi, Krogdahl, Annelise, von Buchwald, Christian, Bilde, Anders, Sebbesen, Lars R, Odell, Edward, Gurney, Benjamin, O'Doherty, Michael, de Bree, Remco, Bloemena, Elisabeth, Flach, Geke B, Villarreal, Pedro M, Fresno Forcelledo, Manuel Florentino, Junquera Gutiérrez, Luis Manuel, Amézaga, Julio Alvarez, Barbier, Luis, Santamaría-Zuazua, Joseba, Moreira, Augusto, Jacome, Manuel, Vigili, Maurizio Giovanni, Rahimi, Siavash, Tartaglione, Girolamo, Lawson, Georges, Nollevaux, Marie-Cécile, Grandi, Cesare, Donner, Davide, Bragantini, Emma, Dequanter, Didier, Lothaire, Philippe, Poli, Tito, Silini, Enrico M, Sesenna, Erinco, Dolivet, Giles, Mastronicola, Romina, Leroux, Agnes, Sassoon, Isabel, Sloan, Philip, and McGurk, Mark

Abstract

PURPOSE: Optimum management of the N0 neck is unresolved in oral cancer. Sentinel node biopsy (SNB) can reliably detect microscopic lymph node metastasis. The object of this study was to establish whether the technique was both reliable in staging the N0 neck and a safe oncological procedure in patients with early-stage oral squamous cell carcinoma. METHODS: An European Organisation for Research and Treatment of Cancer-approved prospective, observational study commenced in 2005. Fourteen European centres recruited 415 patients with radiologically staged T1-T2N0 squamous cell carcinoma. SNB was undertaken with an average of 3.2 nodes removed per patient. Patients were excluded if the sentinel node (SN) could not be identified. A positive SN led to a neck dissection within 3 weeks. Analysis was performed at 3-year follow-up. RESULTS: An SN was found in 99.5% of cases. Positive SNs were found in 23% (94 in 415). A false-negative result occurred in 14% (15 in 109) of patients, of whom eight were subsequently rescued by salvage therapy. Recurrence after a positive SNB and subsequent neck dissection occurred in 22 patients, of which 16 (73%) were in the neck and just six patients were rescued. Only minor complications (3%) were reported following SNB. Disease-specific survival was 94%. The sensitivity of SNB was 86% and the negative predictive value 95%. CONCLUSION: These data show that SNB is a reliable and safe oncological technique for staging the clinically N0 neck in patients with T1 and T2 oral cancer. EORTC Protocol 24021: Sentinel Node Biopsy in the Management of Oral and Oropharyngeal Squamous Cell Carcinoma.

Published
2015

22. Sentinel European Node Trial (SENT):3-year results of sentinel node biopsy in oral cancer

Author

Schilling, Clare, Stoeckli, Sandro J, Haerle, Stephan K, Broglie, Martina A, Huber, Gerhard F, Sorensen, Jens Ahm, Bakholdt, Vivi, Krogdahl, Annelise, von Buchwald, Christian, Bilde, Anders, Sebbesen, Lars R, Odell, Edward, Gurney, Benjamin, O'Doherty, Michael, de Bree, Remco, Bloemena, Elisabeth, Flach, Geke B, Villarreal, Pedro M, Fresno Forcelledo, Manuel Florentino, Junquera Gutiérrez, Luis Manuel, Amézaga, Julio Alvarez, Barbier, Luis, Santamaría-Zuazua, Joseba, Moreira, Augusto, Jacome, Manuel, Vigili, Maurizio Giovanni, Rahimi, Siavash, Tartaglione, Girolamo, Lawson, Georges, Nollevaux, Marie-Cecile, Grandi, Cesare, Donner, Davide, Bragantini, Emma, Dequanter, Didier, Lothaire, Philippe, Poli, Tito, Silini, Enrico M, Sesenna, Erinco, Dolivet, Giles, Mastronicola, Romina, Leroux, Agnes, Sassoon, Isabel, Sloan, Philip, McGurk, Mark, Schilling, Clare, Stoeckli, Sandro J, Haerle, Stephan K, Broglie, Martina A, Huber, Gerhard F, Sorensen, Jens Ahm, Bakholdt, Vivi, Krogdahl, Annelise, von Buchwald, Christian, Bilde, Anders, Sebbesen, Lars R, Odell, Edward, Gurney, Benjamin, O'Doherty, Michael, de Bree, Remco, Bloemena, Elisabeth, Flach, Geke B, Villarreal, Pedro M, Fresno Forcelledo, Manuel Florentino, Junquera Gutiérrez, Luis Manuel, Amézaga, Julio Alvarez, Barbier, Luis, Santamaría-Zuazua, Joseba, Moreira, Augusto, Jacome, Manuel, Vigili, Maurizio Giovanni, Rahimi, Siavash, Tartaglione, Girolamo, Lawson, Georges, Nollevaux, Marie-Cecile, Grandi, Cesare, Donner, Davide, Bragantini, Emma, Dequanter, Didier, Lothaire, Philippe, Poli, Tito, Silini, Enrico M, Sesenna, Erinco, Dolivet, Giles, Mastronicola, Romina, Leroux, Agnes, Sassoon, Isabel, Sloan, Philip, and McGurk, Mark

Abstract

PURPOSE: Optimum management of the N0 neck is unresolved in oral cancer. Sentinel node biopsy (SNB) can reliably detect microscopic lymph node metastasis. The object of this study was to establish whether the technique was both reliable in staging the N0 neck and a safe oncological procedure in patients with early-stage oral squamous cell carcinoma.METHODS: An European Organisation for Research and Treatment of Cancer-approved prospective, observational study commenced in 2005. Fourteen European centres recruited 415 patients with radiologically staged T1-T2N0 squamous cell carcinoma. SNB was undertaken with an average of 3.2 nodes removed per patient. Patients were excluded if the sentinel node (SN) could not be identified. A positive SN led to a neck dissection within 3 weeks. Analysis was performed at 3-year follow-up.RESULTS: An SN was found in 99.5% of cases. Positive SNs were found in 23% (94 in 415). A false-negative result occurred in 14% (15 in 109) of patients, of whom eight were subsequently rescued by salvage therapy. Recurrence after a positive SNB and subsequent neck dissection occurred in 22 patients, of which 16 (73%) were in the neck and just six patients were rescued. Only minor complications (3%) were reported following SNB. Disease-specific survival was 94%. The sensitivity of SNB was 86% and the negative predictive value 95%.CONCLUSION: These data show that SNB is a reliable and safe oncological technique for staging the clinically N0 neck in patients with T1 and T2 oral cancer. EORTC Protocol 24021: Sentinel Node Biopsy in the Management of Oral and Oropharyngeal Squamous Cell Carcinoma.

Published
2015

23. Isolation and Characterization of Human Lung Lymphatic Endothelial Cells

Author

Lorusso, Bruno, primary, Falco, Angela, additional, Madeddu, Denise, additional, Frati, Caterina, additional, Cavalli, Stefano, additional, Graiani, Gallia, additional, Gervasi, Andrea, additional, Rinaldi, Laura, additional, Lagrasta, Costanza, additional, Maselli, Davide, additional, Gnetti, Letizia, additional, Silini, Enrico M., additional, Quaini, Eugenio, additional, Ampollini, Luca, additional, Carbognani, Paolo, additional, and Quaini, Federico, additional

Published
2015
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24. Implications of a positive sentinel node in oral squamous cell carcinoma

Author

Gurney, Benjamin A S, Schilling, Clare, Putcha, Venkata, Alkureishi, Lee W, Alvarez, Amezaga J, Bakholdt, Vivi T., Barbier Herrero, Luis, Barzan, Luigi, Bilde, Anders, Bloemena, Elisabeth, Salces, Carmen Camarero, Dalla Palma, Paolo, de Bree, Remco, Dequanter, Didier, Dolivet, Gilles, Donner, Davide, Flach, Geke B, Fresno, Manuel, Grandi, Cesare, Haerle, Stephan, Huber, Gerhard F, Hunter, Keith, Lawson, George, Leroux, Agnes, Lothaire, Phillippe H, Mamelle, Gerard, Silini, Enrico M, Mastronicola, Romina, Odell, Edward W, O'Doherty, Michael J, Poli, Tito, Rahimi, Siavash, Ross, Gary L, Zuazua, J Santamaria, Santini, Simone, Sebbesen, Lars, Shoaib, Taimur, Sloan, Philip, Sorensen, Jens Ahm, Soutar, David S, Therkildsen, Marianne H, Vigili, Maurizio Giovanni, Villarreal, Pedro M, von Buchwald, Christian, Werner, Jochen A, Wiegand, Susanne, McGurk, Mark, Gurney, Benjamin A S, Schilling, Clare, Putcha, Venkata, Alkureishi, Lee W, Alvarez, Amezaga J, Bakholdt, Vivi T., Barbier Herrero, Luis, Barzan, Luigi, Bilde, Anders, Bloemena, Elisabeth, Salces, Carmen Camarero, Dalla Palma, Paolo, de Bree, Remco, Dequanter, Didier, Dolivet, Gilles, Donner, Davide, Flach, Geke B, Fresno, Manuel, Grandi, Cesare, Haerle, Stephan, Huber, Gerhard F, Hunter, Keith, Lawson, George, Leroux, Agnes, Lothaire, Phillippe H, Mamelle, Gerard, Silini, Enrico M, Mastronicola, Romina, Odell, Edward W, O'Doherty, Michael J, Poli, Tito, Rahimi, Siavash, Ross, Gary L, Zuazua, J Santamaria, Santini, Simone, Sebbesen, Lars, Shoaib, Taimur, Sloan, Philip, Sorensen, Jens Ahm, Soutar, David S, Therkildsen, Marianne H, Vigili, Maurizio Giovanni, Villarreal, Pedro M, von Buchwald, Christian, Werner, Jochen A, Wiegand, Susanne, and McGurk, Mark

Abstract

The role of sentinel node biopsy in head and neck cancer is currently being explored. Patients with positive sentinel nodes were investigated to establish if additional metastases were present in the neck, their distribution, and their impact on outcome.

Published
2012

26. EGFR Mutation-specific Antibodies in Pulmonary Adenocarcinoma

Author

Ambrosini-Spaltro, Andrea, primary, Campanini, Nicoletta, additional, Bortesi, Beatrice, additional, Azzoni, Cinzia, additional, Naldi, Nadia, additional, Ampollini, Luca, additional, Tiseo, Marcello, additional, Ardizzoni, Andrea, additional, Rusca, Michele, additional, Carbognani, Paolo, additional, and Silini, Enrico M., additional

Published
2012
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32. Human leukocyte antigen class II and III alleles and severity of hepatitis C virus-related chronic liver disease

Author

Asti, Margherita, primary, Martinetti, Miryam, additional, Zavaglia, Claudo, additional, Cuccia, Maria Clara, additional, Gusberti, Laura, additional, Tinelli, Carmine, additional, Cividini, Agostino, additional, Bruno, Savino, additional, Salvaneschi, Laura, additional, Ideo, Gaetano, additional, Mondelli, Mario U., additional, and Silini, Enrico M., additional

Published
1999
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33. Dynamics of hypervariable region 1 variation in hepatitis C virus infection and correlation with clinical and virological features of liver disease

Author

Brambilla, Sabrina, primary, Bellati, Giorgio, additional, Asti, Margherita, additional, Lisa, Antonella, additional, Candusso, Maria Elena, additional, D'Amico, Maria, additional, Grassi, Gabriele, additional, Giacca, Mauro, additional, Franchini, Angelo, additional, Bruno, Savino, additional, Ideo, Gaetano, additional, Mondelli, Mario U., additional, and Silini, Enrico M., additional

Published
1998
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34. Extragenital M llerian adenosarcoma with pouch of Douglas location.

Author

Patrelli, Tito S., Silini, Enrico M., Gizzo, Salvatore, Berretta, Roberto, Franchi, Laura, Thai, Elena, Lukanovic, Adolf, Nardelli, Giovanni B., and Modena, Alberto Bacchi

Subjects
GENITALIA tumors, HOSPITALS, RADIOTHERAPY, VAGINA
Abstract

Background: Of all female genital tract tumors, 1-3% are stromal malignancies. In 8-10% of cases, these are represented by Müllerian adenosarcoma an extremely rare tumor characterized by a stromal component of usually low-grade malignancy and by a benign glandular epithelial component. Variant that arises in the pouch of Douglas is scarcely mentioned in the medical literature. Case Presentation: A 49-year-old para-0 woman, was seen at our OB/GYN-UNIT because she complained vaguely of pelvic pain. She had a mass of undefined nature in the pouch of Douglas. A simple excision of the mass showed low-grade Müllerian adenosarcoma with areas of stromal overgrowth. One and a half year after surgery, at another hospital, a mass was detected in the patient's posterior vaginal fornix and removed surgically. Six months later she came back to our observation with vaginal bleeding and mass in the vaginal fornix. We performed radical surgery. The pathological examination showed recurrent adenosarcoma. Surgical treatment was supplemented by radiation therapy. Conclusions: The case of Müllerian adenosarcoma reported here is the third known so far in the literature that was located in the pouch of Douglas. To date, only two other such cases have been reported, including one resulting from neoplastic degeneration of an endometriotic cyst. [ABSTRACT FROM AUTHOR]

Published
2011
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35. EGFR mutation-specific antibodies in pulmonary adenocarcinoma: a comparison with DNA direct sequencing

Author

Cinzia Azzoni, Beatrice Bortesi, Nicoletta Campanini, Luca Ampollini, Nadia Naldi, Marcello Tiseo, Andrea Ambrosini-Spaltro, Enrico Maria Silini, Andrea Ardizzoni, Michele Rusca, Paolo Carbognani, Ambrosini-Spaltro, Andrea, Campanini, Nicoletta, Bortesi, Beatrice, Azzoni, Cinzia, Naldi, Nadia, Ampollini, Luca, Tiseo, Marcello, Ardizzoni, Andrea, Rusca, Michele, Carbognani, Paolo, and Silini, Enrico M.

Subjects
Male, Histology, Lung Neoplasms, medicine.drug_class, EGFR, Antibodie, DNA Mutational Analysis, Protein Kinase Inhibitor, Gene mutation, Adenocarcinoma, Monoclonal antibody, medicine.disease_cause, Sensitivity and Specificity, Tyrosine-kinase inhibitor, Antibodies, DNA Mutational Analysi, Exon, Mutant Protein, medicine, Humans, Epidermal growth factor receptor, Protein Kinase Inhibitors, Aged, Mutation, biology, business.industry, Sequence Analysis, DNA, Middle Aged, lung adenocarcinoma, Molecular biology, Immunohistochemistry, Lung Neoplasm, ErbB Receptors, Medical Laboratory Technology, Drug Resistance, Neoplasm, biology.protein, Female, Mutant Proteins, Receptor, Epidermal Growth Factor, Anatomy, Antibody, business, Human
Abstract

INTRODUCTION Epidermal growth factor receptor (EGFR) gene mutations are usually detected by direct sequencing to identify patients with advanced pulmonary adenocarcinomas as candidates for tyrosine kinase inhibitor therapy. The aim of the study was to evaluate the efficacy of EGFR mutation-specific antibodies in identifying EGFR-mutated adenocarcinomas. MATERIALS AND METHODS Thirty-three consecutive cases of pulmonary adenocarcinomas sequenced for EGFR mutations were retrieved from our files. Immunohistochemistry was performed with the rabbit monoclonal antibodies E746-A750del (6B6) and L858R (43B2). The results obtained using the 2 procedures were statistically compared by Coehn κ and by calculation of sensitivity and specificity. RESULTS There were 21 women and 12 men, ranging in age from 48 to 78 years. All cases were lung adenocarcinomas, 23 primaries and 10 metastatic. The mutational spectrum was as follows: 12 cases mutated in exon 19 (9 with E746-A750del, 1 with homozygote L747-T751del, 1 with L747-P753del, 1 with E747-S752del), 6 in exon 21 (5 with L858R, 1 with L861Q+L862L), and 15 EGFR wild type. Immunohistochemistry detected 6/9 cases with an E746-A750del mutation (κ=0.744, sensitivity: 66.7%, specificity: 100%) and 5/5 cases with an L858R mutation (κ=1, sensitivity: 100%, specificity: 100%). Four cases showed faint and focal immunostaining and were interpreted as negative. All other cases were negative. Overall, the 2 antibodies had 61.1% sensitivity and 100% specificity for EGFR mutations. CONCLUSIONS EGFR mutation-specific antibodies may represent a first-line screening tool to identify patients as candidates for tyrosine kinase inhibitor therapy.

Published
2012

36. Codon 72 polymorphism of P53 gene does not affect the risk of cirrhosis and hepatocarcinoma in HCV-infected patients.

Author

Leveri M, Gritti C, Rossi L, Zavaglia C, Civardi E, Mondelli MU, De Silvestri A, and Silini EM

Subjects
Aged, Carcinoma, Hepatocellular virology, Codon genetics, DNA, Neoplasm analysis, DNA, Neoplasm genetics, Hepatitis C genetics, Humans, Liver Cirrhosis virology, Liver Neoplasms genetics, Liver Neoplasms virology, Male, Middle Aged, Risk Factors, Carcinoma, Hepatocellular genetics, Genes, p53 genetics, Hepacivirus pathogenicity, Hepatitis C complications, Liver Cirrhosis genetics, Polymorphism, Genetic
Abstract

Chronic hepatitis C virus (HCV) infection is the most frequent cause of progressive liver disease and liver cancer in the West. The p53 tumor suppressor gene is known to play an important role in carcinogenesis of different tissues being involved in gene transcription, DNA synthesis and repair and somatic mutations of p53 are common in primary liver cancer. The p53 gene displays a common genetic Arg/Pro polymorphism at codon 72 with functional significance, that has been investigated as risk factor in several cancer models. We analyzed p53 codon 72 polymorphism in a group of 340 HCV-infected subjects at different stages of disease, including 84 hepatocellular carcinoma patients. No association between codon 72 genotypes and disease severity or liver cancer was observed.

Published
2004
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