25 results on '"Sileo, Filomena Giulia"'
Search Results
2. Outcome of fetal congenital pulmonary malformations: a systematic review and meta-analysis
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Sileo, Filomena Giulia, primary, Alameddine, Sara, additional, Iaccarino, Daniela Anna, additional, Di Mascio, Daniele, additional, Giuliani, Giulia Andrea, additional, Bertucci, Emma, additional, Khalil, Asma, additional, and D’Antonio, Francesco, additional
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- 2024
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3. Ovarian Cancer Biomarkers: Immunohistochemical Surrogates for Molecular Alterations
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Palicelli, Andrea, primary, Kuhn, Elisabetta, additional, Melli, Beatrice, additional, Sileo, Filomena Giulia, additional, and Mandato, Vincenzo Dario, additional
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- 2022
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4. Role of prenatal magnetic resonance imaging in fetuses with isolated severe ventriculomegaly at neurosonography: A multicenter study
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Di Mascio, Daniele, Khalil, Asma, Pilu, Gianluigi, Rizzo, Giuseppe, Caulo, Massimo, Liberati, Marco, Giancotti, Antonella, Lees, Christoph, Volpe, Paolo, Buca, Danilo, Oronzi, Ludovica, D'Amico, Alice, Tinari, Sara, Stampalija, Tamara, Fantasia, Ilaria, Pasquini, Lucia, Masini, Giulia, Brunelli, Roberto, D'Ambrosio, Valentina, Muzii, Ludovico, Manganaro, Lucia, Antonelli, Amanda, Ercolani, Giada, Ciulla, Sandra, Saccone, Gabriele, Maruotti, Giuseppe Maria, Carbone, Luigi, Zullo, Fulvio, Olivieri, Claudiana, Ghi, Tullio, Frusca, Tiziana, Dall'Asta, Andrea, Visentin, Silvia, Cosmi, Erich, Forlani, Francesco, Galindo, Alberto, Villalain, Cecilia, Herraiz, Ignacio, Sileo, Filomena Giulia, Mendez Quintero, Olivia, Salsi, Ginevra, Bracalente, Gabriella, Morales-Roselló, José, Loscalzo, Gabriela, Pellegrino, Marcella, De Santis, Marco, Lanzone, Antonio, Parazzini, Cecilia, Lanna, Mariano, Ormitti, Francesca, Toni, Francesco, Murru, Flora, Di Maurizio, Marco, Trincia, Elena, Garcia, Raquel, Bennike Bjørn Petersen, Olav, Neerup, Lisa, Sandager, Puk, Prefumo, Federico, Pinelli, Lorenzo, Mappa, Ilenia, Acuti Martellucci, Cecilia, Flacco, Maria Elena, Manzoli, Lamberto, Giangiordano, Ilaria, Nappi, Luigi, Scambia, Giovanni, Berghella, Vincenzo, and D'Antonio, Francesco
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- 2021
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5. Isthmocele diagnosis: The optimal timing for detection.
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Bertucci, Emma, Sileo, Filomena Giulia, Longo, Maria, Tarozzi, Giulia, Benuzzi, Martina, and La Marca, Antonio
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MEDICAL sciences , *CESAREAN section , *DIAGNOSTIC ultrasonic imaging , *TRANSVAGINAL ultrasonography , *MENSTRUAL cycle , *UTERINE hemorrhage , *UTERINE rupture , *VAGINAL birth after cesarean , *HYSTEROSCOPY - Abstract
This article discusses the diagnosis of isthmocele, a uterine defect that occurs at the site of a previous cesarean section or other uterine surgeries. It affects up to 70% of women with a history of cesarean sections and can cause symptoms such as abnormal uterine bleeding and abdominal pain. Accurate diagnosis is important as isthmocele has been linked to complications in future pregnancies. Transvaginal ultrasonography is the primary diagnostic method, and the study suggests that performing the ultrasound during the secretive phase of the menstrual cycle provides clearer visualization of the isthmocele. Surgical correction can be done depending on the size of the defect. [Extracted from the article]
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- 2024
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6. Role of fetal magnetic resonance imaging in fetuses with congenital cytomegalovirus infection: multicenter study
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Di Mascio, D., Rizzo, G., Khalil, A., D'Antonio, F., Di Mascio, Daniele, Rizzo, Giuseppe, Khalil, Asma, Giancotti, Antonella, Manganaro, Lucia, Visentin, Silvia, Cosmi, Erich, Prefumo, Federico, Stampalija, Tamara, D'Ambrosio, Valentina, Brunelli, Roberto, Liberati, Marco, Buca, Danilo, Matarrelli, Barbara, D'Amico, Alice, Oronzii, Ludovica, Tinari, Sara, Caulo, Massimo, Gentile, Luigia, Fantasia, Ilaria, Mappa, Ilenia, Maruotti, Giuseppe Maria, Saccone, Gabriele, Carbone, Luigi, Sarno, Laura, Bracalente, Gabriella, Bertucci, Emma, Sileo, Filomena Giulia, Pellegrino, Marcella, De Santis, Marco, Lanzone, Antonio, Pinelli, Lorenzo, Murru, Flora, Trincia, Elena, Pajno, Cristina, Sorrenti, Sara, Vasciaveo, Lorenzo, Nappi, Luigi, Greco, Pantaleo, D'Antonio, Francesco, Di Mascio, D., Rizzo, G., Khalil, A., D'Antonio, F., Di Mascio, Daniele, Rizzo, Giuseppe, Khalil, Asma, Giancotti, Antonella, Manganaro, Lucia, Visentin, Silvia, Cosmi, Erich, Prefumo, Federico, Stampalija, Tamara, D'Ambrosio, Valentina, Brunelli, Roberto, Liberati, Marco, Buca, Danilo, Matarrelli, Barbara, D'Amico, Alice, Oronzii, Ludovica, Tinari, Sara, Caulo, Massimo, Gentile, Luigia, Fantasia, Ilaria, Mappa, Ilenia, Maruotti, Giuseppe Maria, Saccone, Gabriele, Carbone, Luigi, Sarno, Laura, Bracalente, Gabriella, Bertucci, Emma, Sileo, Filomena Giulia, Pellegrino, Marcella, De Santis, Marco, Lanzone, Antonio, Pinelli, Lorenzo, Murru, Flora, Trincia, Elena, Pajno, Cristina, Sorrenti, Sara, Vasciaveo, Lorenzo, Nappi, Luigi, Greco, Pantaleo, and D'Antonio, Francesco
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Radiological and Ultrasound Technology ,CMV ,MRI ,cytomegalovirus ,hearing loss ,infection ,neurosonography ,ultrasound ,Obstetrics and Gynecology ,General Medicine ,Reproductive Medicine ,Settore MED/40 ,Radiology, Nuclear Medicine and imaging - Abstract
To investigate the role of fetal brain magnetic resonance imaging (MRI) in detecting associated anomalies in fetuses with congenital cytomegalovirus (CMV) infection and normal neurosonography.This was a multicenter, retrospective cohort study of patients examined between 2012 and 2021 in 11 referral fetal medicine centers in Italy. Inclusion criteria were fetuses with congenital CMV infection diagnosed by polymerase chain reaction analysis of amniotic fluid, pregnancies that underwent detailed multiplanar ultrasound assessment of the fetal brain as recommended by the International Society of Ultrasound in Obstetrics and Gynecology, maternal age ≥ 18 years, normal fetal karyotype and MRI performed within 3 weeks after the last ultrasound examination. The primary outcome was the rate of central nervous system (CNS) anomalies detected exclusively on MRI and confirmed after birth or autopsy in fetuses with a prenatal diagnosis of congenital CMV infection and normal neurosonography at diagnosis. Additional CNS anomalies were classified into anomalies of the ventricular and the periventricular zone, intracranial calcifications in the basal ganglia or germinal matrix, destructive encephalopathy in the white matter, malformations of cortical development, midline anomalies, posterior fossa anomalies and complex brain anomalies. We evaluated the relationship between the incidence of structural CNS malformations diagnosed exclusively on fetal MRI and a number of maternal and gestational characteristics. Univariate and multivariate logistic regression analyses were used to identify and adjust for potential independent predictors of the MRI diagnosis of fetal anomalies.The analysis included 95 fetuses with a prenatal diagnosis of congenital CMV infection and normal neurosonography referred for prenatal MRI. The rate of structural anomalies detected exclusively at fetal MRI was 10.5% (10/95). When considering the type of anomaly, malformations of cortical development were detected on MRI in 40.0% (4/10) of fetuses, destructive encephalopathy in 20.0% (2/10), intracranial calcifications in the germinal matrix in 10.0% (1/10) and complex CNS anomalies in 30.0% (3/10). On multivariate logistic regression analysis, only CMV viral load in the amniotic fluid, expressed as a continuous variable (odds ratio (OR), 1.16 (95% CI, 1.02-1.21); P = 0.02) or categorical variable ( 100 000 copies/mL) (OR, 12.0 (95% CI, 1.2-124.7); P = 0.04), was independently associated with the likelihood of detecting fetal anomalies on MRI. Associated anomalies were detected exclusively at birth and missed by both prenatal neurosonography and fetal MRI in 3.8% (3/80) of fetuses with congenital CMV infection.Fetal brain MRI can detect additional anomalies in a significant proportion of fetuses with congenital CMV infection and negative neurosonography. Viral load in the amniotic fluid was an independent predictor of the risk of associated anomalies in these fetuses. The findings of this study support a longitudinal evaluation using fetal MRI in congenital CMV infection, even in cases with negative neurosonography at diagnosis. © 2022 International Society of Ultrasound in Obstetrics and Gynecology.
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- 2023
7. Screening for Low-Tract Genital Infections in Women with Threatened Preterm Labor: Which Role?
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Sileo, F, Inversetti, A, Bonati, F, Celora, G, Donno, V, Giuliani, G, Pellegrini, R, Monari, F, Locatelli, A, Facchinetti, F, Sileo, Filomena Giulia, Inversetti, Annalisa, Bonati, Francesca, Celora, Gabriella, Donno, Valeria, Giuliani, Giulia Andrea, Pellegrini, Rosamaria, Monari, Francesca, Locatelli, Anna, Facchinetti, Fabio, Sileo, F, Inversetti, A, Bonati, F, Celora, G, Donno, V, Giuliani, G, Pellegrini, R, Monari, F, Locatelli, A, Facchinetti, F, Sileo, Filomena Giulia, Inversetti, Annalisa, Bonati, Francesca, Celora, Gabriella, Donno, Valeria, Giuliani, Giulia Andrea, Pellegrini, Rosamaria, Monari, Francesca, Locatelli, Anna, and Facchinetti, Fabio
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Objectives: The aim of this study was to evaluate the possible relationship between cultural specimens and preterm birth in women admitted for threatened preterm labor. Preterm birth is the leading cause of neonatal mortality and antenatal hospitalization; several risk factors including intrauterine infections have been identified, but its real causes remain poorly understood. Design: This is a retrospective, multicenter, cohort study including 250 women admitted for threatened preterm labor. Methods, Participants/Materials, Setting: All women admitted for threatened preterm labor, i.e., presenting with cervical changes and uterine activity before 37 weeks at the obstetrics unit of the hospitals of Modena, Monza, Carate, and Vimercate were included in the study. We excluded twin pregnancies and cases with preterm premature rupture of membranes at admission. Data about maternal history, pregnancy complications, cervical length, vaginal swabs, and urine culture at admission and gestational age at delivery were collected from clinical records in order to compare the incidence of preterm birth according to some known risk factors, cervical length, and microbiological test at admission. Results: 250 women were included in the study; preterm birth at less than 37 weeks occurred in 44.4% women admitted for threatened preterm labor. The incidence of preterm birth was not different between those with a positive or a negative vaginal swab (48.3 vs. 38.4%, p = 0.22) or positive versus negative urine culture (31.8 vs. 42.1%, p = 0.23) at admission. A shorter cervical length at admission was found in women with subsequent preterm birth (17 vs. 19.5 mm, p = 0.03). Cervical length <15 mm (OR 1.82, 95% CI: 1.03-3.23, p = 0.039) predicted the risk of preterm birth. Furthermore, only the history of a previous preterm birth (p = 0.02) and a previous uterine curettage (p = 0.045) was associated with preterm birth. Limitations: The observational and retrospective nature of the study
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- 2022
8. Screening for Low-Tract Genital Infections in Women with Threatened Preterm Labor: Which Role?
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Sileo, Filomena Giulia, primary, Inversetti, Annalisa, additional, Bonati, Francesca, additional, Celora, Gabriella, additional, Donno, Valeria, additional, Giuliani, Giulia Andrea, additional, Pellegrini, Rosamaria, additional, Monari, Francesca, additional, Locatelli, Anna, additional, and Facchinetti, Fabio, additional
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- 2022
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9. Diagnostic performance of cerebroplacental and umbilicocerebral ratio in appropriate for gestational age and late growth restricted fetuses attempting vaginal delivery: a multicenter, retrospective study.
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Villalain, Cecilia, Galindo, Alberto, Di Mascio, Daniele, Buca, Danilo, Morales-Rosello, Jose, Loscalzo, Gabriela, Sileo, Filomena Giulia, Finarelli, Alessandra, Bertucci, Emma, Facchinetti, Fabio, Rizzo, Giuseppe, Brunelli, Roberto, Giancotti, Antonella, Muzii, Ludovico, Maruotti, Giuseppe Maria, Carbone, Luigi, D’Amico, Alice, Tinari, Sara, Morelli, Roberta, and Cerra, Chiara
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DELIVERY (Obstetrics) ,GESTATIONAL age ,FETAL development ,PLACENTAL growth factor ,NEONATAL intensive care units ,FETAL growth retardation - Abstract
Background Cerebroplacental Doppler studies have been advocated to predict the risk of adverse perinatal outcome (APO) irrespective of fetal weight. Objective To report the diagnostic performance of cerebroplacental (CPR) and umbilicocerebral (UCR) ratios in predicting APO in appropriate for gestational age (AGA) fetuses and in those affected by late fetal growth restriction (FGR) attempting vaginal delivery. Study design Multicenter, retrospective, nested case-control study between 1 January 2017 and January 2020 involving five referral centers in Italy and Spain. Singleton gestations with a scan between 36 and 40 weeks and within two weeks of attempting vaginal delivery were included. Fetal arterial Doppler and biometry were collected. The AGA group was defined as fetuses with an estimated fetal weight and abdominal circumference >10th and <90th percentile, while the late FGR group was defined by Delphi consensus criteria. The primary outcome was the prediction of a composite of perinatal adverse outcomes including either intrauterine death, Apgar score at 5 min <7, abnormal acid-base status (umbilical artery pH < 7.1 or base excess of more than −11) and neonatal intensive care unit (NICU) admission. Area under the curve (AUC) analysis was performed. Results 646 pregnancies (317 in the AGA group and 329 in the late FGR group) were included. APO were present in 12.6% AGA and 24.3% late FGR pregnancies, with an odds ratio of 2.22 (95% CI 1.46–3.37). The performance of CPR and UCR for predicting APO was poor in both AGA [AUC: 0.44 (0.39–0.51)] and late FGR fetuses [AUC: 0.56 (0.49–0.61)]. Conclusions CPR and UCR on their own are poor prognostic predictors of APO irrespective of fetal weight. [ABSTRACT FROM AUTHOR]
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- 2022
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10. Role of prenatal magnetic resonance imaging in fetuses with isolated severe ventriculomegaly at neurosonography:A multicenter study
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Di Mascio, Daniele, Khalil, Asma, Pilu, Gianluigi, Rizzo, Giuseppe, Caulo, Massimo, Liberati, Marco, Giancotti, Antonella, Lees, Christoph, Volpe, Paolo, Buca, Danilo, Oronzi, Ludovica, D'Amico, Alice, Tinari, Sara, Stampalija, Tamara, Fantasia, Ilaria, Pasquini, Lucia, Masini, Giulia, Brunelli, Roberto, D'Ambrosio, Valentina, Muzii, Ludovico, Manganaro, Lucia, Antonelli, Amanda, Ercolani, Giada, Ciulla, Sandra, Saccone, Gabriele, Maruotti, Giuseppe Maria, Carbone, Luigi, Zullo, Fulvio, Olivieri, Claudiana, Ghi, Tullio, Frusca, Tiziana, Dall'Asta, Andrea, Visentin, Silvia, Cosmi, Erich, Forlani, Francesco, Galindo, Alberto, Villalain, Cecilia, Herraiz, Ignacio, Sileo, Filomena Giulia, Mendez Quintero, Olivia, Salsi, Ginevra, Bracalente, Gabriella, Morales-Roselló, José, Loscalzo, Gabriela, Pellegrino, Marcella, De Santis, Marco, Lanzone, Antonio, Parazzini, Cecilia, Lanna, Mariano, Ormitti, Francesca, Toni, Francesco, Murru, Flora, Di Maurizio, Marco, Trincia, Elena, Garcia, Raquel, Bennike Bjørn Petersen, Olav, Neerup, Lisa, Sandager, Puk, Prefumo, Federico, Pinelli, Lorenzo, Mappa, Ilenia, Acuti Martellucci, Cecilia, Flacco, Maria Elena, Manzoli, Lamberto, Giangiordano, Ilaria, Nappi, Luigi, Scambia, Giovanni, Berghella, Vincenzo, D'Antonio, Francesco, Di Mascio, Daniele, Khalil, Asma, Pilu, Gianluigi, Rizzo, Giuseppe, Caulo, Massimo, Liberati, Marco, Giancotti, Antonella, Lees, Christoph, Volpe, Paolo, Buca, Danilo, Oronzi, Ludovica, D'Amico, Alice, Tinari, Sara, Stampalija, Tamara, Fantasia, Ilaria, Pasquini, Lucia, Masini, Giulia, Brunelli, Roberto, D'Ambrosio, Valentina, Muzii, Ludovico, Manganaro, Lucia, Antonelli, Amanda, Ercolani, Giada, Ciulla, Sandra, Saccone, Gabriele, Maruotti, Giuseppe Maria, Carbone, Luigi, Zullo, Fulvio, Olivieri, Claudiana, Ghi, Tullio, Frusca, Tiziana, Dall'Asta, Andrea, Visentin, Silvia, Cosmi, Erich, Forlani, Francesco, Galindo, Alberto, Villalain, Cecilia, Herraiz, Ignacio, Sileo, Filomena Giulia, Mendez Quintero, Olivia, Salsi, Ginevra, Bracalente, Gabriella, Morales-Roselló, José, Loscalzo, Gabriela, Pellegrino, Marcella, De Santis, Marco, Lanzone, Antonio, Parazzini, Cecilia, Lanna, Mariano, Ormitti, Francesca, Toni, Francesco, Murru, Flora, Di Maurizio, Marco, Trincia, Elena, Garcia, Raquel, Bennike Bjørn Petersen, Olav, Neerup, Lisa, Sandager, Puk, Prefumo, Federico, Pinelli, Lorenzo, Mappa, Ilenia, Acuti Martellucci, Cecilia, Flacco, Maria Elena, Manzoli, Lamberto, Giangiordano, Ilaria, Nappi, Luigi, Scambia, Giovanni, Berghella, Vincenzo, and D'Antonio, Francesco
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Objective: The aim of this study was to report the rate of additional anomalies detected exclusively at prenatal magnetic resonance imaging (MRI) in fetuses with isolated severe ventriculomegaly undergoing neurosonography. Method: Multicenter, retrospective, cohort study involving 20 referral fetal medicine centers in Italy, United Kingdom, Spain and Denmark. Inclusion criteria were fetuses affected by isolated severe ventriculomegaly (≥15 mm), defined as ventriculomegaly with normal karyotype and no other additional central nervous system (CNS) and extra-CNS anomalies on ultrasound. In all cases, a multiplanar assessment of fetal brain as suggested by ISUOG guidelines on fetal neurosonography had been performed. The primary outcome was the rate of additional CNS anomalies detected exclusively at fetal MRI within two weeks from neurosonography. Subgroup analyses according to gestational age at MRI (
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- 2021
11. Role of prenatal magnetic resonance imaging in fetuses with isolated anomalies of corpus callosum: multinational study
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Sileo, Filomena Giulia, Pilu, Gianluigi, Prayer, Daniela, Rizzo, Giuseppe, Khalil, Asma, Managanaro, Lucia, Volpe, Paolo, Van Mieghem, Tim, Bertucci, Emma, Morales Rosello, Jose, Facchinetti, Fabio, Di Mascio, Daniele, Stampalija, Tamara, Buca, Danilo, Tinari, Sara, Oronzi, Ludovica, Ercolani, Giada, D'Amico, Alice, Matarrelli, Barbara, Cerra, Chiara, Fantasia, Ilaria, Pasquini, Lucia, Masini, Giulia, Olivieri, Claudiana, Ghi, Tullio, Frusca, Tiziana, Dall'Asta, Andrea, Visentin, Silvia, Cosmi, Erich, D'Errico, Ignazio, Villalain, Cecilia, Quintero, Olivia Mendez, Giancotti, Antonella, D'Ambrosio, Valentina, Antonelli, Amanda, Caulo, Massimo, Panara, Valentina, De Santis, Marco, Mappa, Ilenia, Prefumo, Federico, Pinelli, Lorenzo, Loscalzo, Gabriela, Bracalente, Gabriella, Liberati, Marco, Filippi, Elisa, Trincia, Elena, Pateisky, Petra, Kiss, Herbert, Curado, Joana, Almeida, Marta, Santos, Antonia, Galindo, Alberto, D'Antonio, Francesco, and ENSO Working Grp
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corpus callosum ,prenatal diagnosis ,fetal ultrasound ,fetal magnetic resonance imaging ,central nervous system ,MRI ,neurosonography - Abstract
Objective To assess the performance of fetal magnetic resonance imaging (MRI) in detecting associated anomalies in fetuses diagnosed with isolated corpus callosal (CC) anomaly on multiplanar ultrasound evaluation of the fetal brain (neurosonography). Methods This was a multicenter, retrospective cohort study involving 14 fetal medicine centers in Italy, UK, Portugal, Canada, Austria and Spain. Inclusion criteria were fetuses with an apparently isolated CC anomaly, defined as an anomaly of the CC and no other additional central nervous system (CNS) or extra-CNS abnormality detected on expert ultrasound, including multiplanar neurosonography; normal karyotype; maternal age >= 18 years; and gestational age at diagnosis >= 18 weeks. The primary outcome was the rate of additional CNS abnormalities detected exclusively on fetal MRI within 2 weeks following neurosonography. The secondary outcomes were the rate of additional abnormalities according to the type of CC abnormality (complete (cACC) or partial (pACC) agenesis of the CC) and the rate of additional anomalies detected only on postnatal imaging or at postmortem examination. Results A total of 269 fetuses with a sonographic prenatal diagnosis of apparently isolated CC anomalies (207 with cACC and 62 with pACC) were included in the analysis. Additional structural anomalies of the CNS were detected exclusively on prenatal MRI in 11.2% (30/269) of cases, with malformations of cortical development representing the most common type of anomaly. When stratifying the analysis according to the type of CC anomaly, the rate of associated anomalies detected exclusively on MRI was 11.6% (24/207) in cACC cases and 9.7% (6/62) in pACC cases. On multivariate logistic regression analysis, only maternal body mass index was associated independently with the likelihood of detecting associated anomalies on MRI (odds ratio, 1.07 (95% CI, 1.01-1.14); P = 0.03). Associated anomalies were detected exclusively after delivery and were missed on both types of prenatal imaging in 3.9% (8/205) of fetuses with prenatal diagnosis of isolated anomaly of the CC. Conclusion In fetuses with isolated anomaly of the CC diagnosed on antenatal neurosonography, MRI can identify a small proportion of additional anomalies, mainly malformations of cortical development, which are not detected on ultrasound. (c) 2021 International Society of Ultrasound in Obstetrics and Gynecology.
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- 2021
12. How Can We Treat Vulvar Carcinoma in Pregnancy? A Systematic Review of the Literature
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Palicelli, Andrea, primary, Giaccherini, Lucia, additional, Zanelli, Magda, additional, Bonasoni, Maria Paola, additional, Gelli, Maria Carolina, additional, Bisagni, Alessandra, additional, Zanetti, Eleonora, additional, De Marco, Loredana, additional, Torricelli, Federica, additional, Manzotti, Gloria, additional, Gugnoni, Mila, additional, D’Ippolito, Giovanni, additional, Falbo, Angela Immacolata, additional, Sileo, Filomena Giulia, additional, Aguzzoli, Lorenzo, additional, Mastrofilippo, Valentina, additional, Bonacini, Martina, additional, De Giorgi, Federica, additional, Ricci, Stefano, additional, Bernardelli, Giuditta, additional, Ardighieri, Laura, additional, Zizzo, Maurizio, additional, De Leo, Antonio, additional, Santandrea, Giacomo, additional, de Biase, Dario, additional, Ragazzi, Moira, additional, Dalla Dea, Giulia, additional, Veggiani, Claudia, additional, Carpenito, Laura, additional, Sanguedolce, Francesca, additional, Asaturova, Aleksandra, additional, Boldorini, Renzo, additional, Disanto, Maria Giulia, additional, Goia, Margherita, additional, Wong, Richard Wing-Cheuk, additional, Singh, Naveena, additional, and Mandato, Vincenzo Dario, additional
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- 2021
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13. Perinatal outcomes of twin pregnancies complicated by late twin‐twin transfusion syndrome: A systematic review and meta‐analysis
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Sileo, Filomena Giulia, primary, D’antonio, Francesco, additional, Benlioglu, Can, additional, Bhide, Amar, additional, and Khalil, Asma, additional
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- 2021
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14. Comparison between Cerebroplacental Ratio and Umbilicocerebral Ratio in Predicting Adverse Perinatal Outcome in Pregnancies Complicated by Late Fetal Growth Restriction: A Multicenter, Retrospective Study
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Di Mascio, Daniele, primary, Herraiz, Ignacio, additional, Villalain, Cecilia, additional, Buca, Danilo, additional, Morales-Rossello, Jose, additional, Loscalzo, Gabriela, additional, Sileo, Filomena Giulia, additional, Finarelli, Alessandra, additional, Bertucci, Emma, additional, Facchinetti, Fabio, additional, Rizzo, Giuseppe, additional, Brunelli, Roberto, additional, Giancotti, Antonella, additional, Muzii, Ludovico, additional, Maruotti, Giuseppe Maria, additional, Carbone, Luigi, additional, D’Amico, Alice, additional, Tinari, Sara, additional, Morelli, Roberta, additional, Cerra, Chiara, additional, Nappi, Luigi, additional, Greco, Pantaleo, additional, Liberati, Marco, additional, Galindo, Alberto, additional, and D’Antonio, Francesco, additional
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- 2021
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15. Role of prenatal magnetic resonance imaging in fetuses with isolated agenesis of corpus callosum in the era of fetal neurosonography: A systematic review and meta‐analysis
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Sileo, Filomena Giulia, primary, Di Mascio, Daniele, additional, Rizzo, Giuseppe, additional, Caulo, Massimo, additional, Manganaro, Lucia, additional, Bertucci, Emma, additional, Masmejan, Sophie, additional, Liberati, Marco, additional, D’Amico, Alice, additional, Nappi, Luigi, additional, Buca, Danilo, additional, Van Mieghem, Tim, additional, Khalil, Asma, additional, and D’Antonio, Francesco, additional
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- 2020
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16. A survey of current clinical practice of chorionic villus sampling
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Sileo, Filomena Giulia, primary, Curado, Joana, additional, and Bhide, Amarnath, additional
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- 2019
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17. Hormonal contraception in women with endometriosis: a systematic review
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Grandi, Giovanni, primary, Barra, Fabio, additional, Ferrero, Simone, additional, Sileo, Filomena Giulia, additional, Bertucci, Emma, additional, Napolitano, Antonella, additional, and Facchinetti, Fabio, additional
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- 2019
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18. Role of prenatal magnetic resonance imaging in fetuses with isolated agenesis of corpus callosum in the era of fetal neurosonography: A systematic review and meta‐analysis.
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Sileo, Filomena Giulia, Di Mascio, Daniele, Rizzo, Giuseppe, Caulo, Massimo, Manganaro, Lucia, Bertucci, Emma, Masmejan, Sophie, Liberati, Marco, D'Amico, Alice, Nappi, Luigi, Buca, Danilo, Van Mieghem, Tim, Khalil, Asma, and D'Antonio, Francesco
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FETAL MRI , *AGENESIS of corpus callosum , *FETAL abnormalities , *PRENATAL diagnosis , *GESTATIONAL age - Abstract
Introduction: Corpus callosum agenesis (ACC) is frequently diagnosed during fetal life; its prognosis depends also on additional anomalies. The additional value of fetal magnetic resonance imaging (MRI) in fetuses with "isolated" complete (cACC) and partial (pACC) agenesis of the corpus callosum on ultrasound is still debated. Material and methods: We performed a systematic literature review and meta‐analysis including fetuses with a prenatal diagnosis of cACC and pACC without associated structural anomalies on ultrasound, undergoing fetal MRI. The primary outcome was the rate of additional anomalies detected at fetal MRI. Further analyses assessed the effect of type of ultrasound assessment (neurosonography vs standard axial assessment), gestational age at fetal MRI and rate of postnatally detected brain anomalies. Random‐effect meta‐analyses of proportions were used to analyze the data. Results: Fourteen studies (798 fetuses) were included. In cases with isolated cACC, 10.9% (95% CI 4.1‐20.6) and 4.3% (95% CI 1.4‐8.8) additional anomalies were detected by fetal MRI and postnatally, respectively. Stratifying according to the type of ultrasound assessment, the rate of associated anomalies detected only on fetal MRI was 5.7% (95% CI 0.5‐16.0) with dedicated neurosonography and 18.5% (95% CI 7.8‐32.4) with a standard axial assessment. In fetuses with isolated pACC, 13.4% (95% CI 4.0‐27.0) and 16.2% (95% CI 5.9‐30.3) additional anomalies were detected by fetal MRI or postnatally, respectively. Stratifying according to the type of ultrasound assessment, the rate of associated anomalies detected only on fetal MRI was 11.4% (95% CI 2.7‐25.0) when dedicated neurosonography was performed. Cortical and posterior fossa anomalies represented the most common anomalies missed at ultrasound with both cACC and pACC. Due to the very small number of included cases, stratification according to early (<24 weeks of gestation) and late (>24 weeks) fetal MRI could not be done for either cACC or pACC. Conclusions: The rate of associated anomalies detected exclusively at fetal MRI in isolated ACC undergoing neurosonography is lower than previously reported. Cortical and posterior fossa anomalies are among the most common anomalies detected exclusively at MRI, thus confirming the crucial role of fetal MRI in determining the prognosis of these fetuses. However, some anomalies still go undetected prenatally and this should be stressed during parental counseling. [ABSTRACT FROM AUTHOR]
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- 2021
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19. Levonorgestrel-releasing intra-uterine systems as female contraceptives
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Grandi, Giovanni, primary, Farulla, Antonino, additional, Sileo, Filomena Giulia, additional, and Facchinetti, Fabio, additional
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- 2018
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20. The Jellyfish Sign: A New Sonographic Cervical Marker to Predict Maternal Morbidity in Abnormally Invasive Placenta Previa.
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Bertucci, Emma, Sileo, Filomena Giulia, Grandi, Giovanni, Fenu, Valentina, Cani, Carlotta, Mancini, Luciano, Mataca, Ema, and Facchinetti, Fabio
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- 2019
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21. Perinatal outcome of monochorionic twin pregnancy complicated by selective fetal growth restriction according to management: systematic review and meta-analysis.
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Townsend, R., D'Antonio, F., Sileo, F. G., Kumbay, H., Thilaganathan, B., Khalil, A., Townsend, Rosemary, D'Antonio, Francesco, Sileo, Filomena Giulia, Kumbay, Hafsah, Thilaganathan, Basky, and Khalil, Asma
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FETAL growth retardation ,INFANT mortality ,EVALUATION of medical care ,META-analysis ,MULTIPLE pregnancy ,PREGNANCY ,TWINS ,SYSTEMATIC reviews ,DIAGNOSIS - Abstract
Objective: To explore the impact of severity and management (expectant, laser treatment or selective reduction) on perinatal outcome of monochorionic twin pregnancies complicated by selective fetal growth restriction (sFGR).Methods: MEDLINE, EMBASE, CINAHL, ClinicalTrials.gov and The Cochrane Library databases were searched for studies on outcome following expectant management, laser treatment or selective reduction in monochorionic twin pregnancies complicated by sFGR. Only pregnancies affected by sFGR and categorized according to the Gratacós classification (Type I, II or III) were included. The primary outcome was mortality, including single and double intrauterine (IUD), neonatal (NND) and perinatal deaths. Secondary outcomes were neonatal morbidity, abnormal postnatal brain imaging, intraventricular hemorrhage, periventricular leukomalacia, respiratory distress syndrome, admission to neonatal intensive care unit and survival free from neurological complications (intact survival). Meta-analyses of proportions were used to analyze the extracted data according to management, severity of sFGR and fetal size (smaller vs larger twin).Results: Sixteen observational studies (786 monochorionic twin pregnancies) were included. In pregnancies complicated by Type-I sFGR managed expectantly, IUD occurred in 3.1% (95% CI, 1.1-5.9%) of fetuses and 97.9% (95% CI, 93.6-99.9%) of twins had intact survival. In pregnancies complicated by Type-I sFGR treated using laser therapy, IUD occurred in 16.7% (95% CI, 0.4-64.1%) of fetuses and, in those treated using selective reduction, IUD occurred in 0% (95% CI, 0-34.9%) of cotwins, with no evidence of neurological complications in the survivors. In pregnancies complicated by Type-II sFGR managed expectantly, IUD occurred in 16.6% (95% CI, 6.9-29.5%) and NND in 6.4% (95% CI, 0.2-28.2%) of fetuses, and 89.3% (95% CI, 71.8-97.7%) of twins survived without neurological compromise. In Type-II sFGR pregnancies treated using laser therapy, IUD occurred in 44.3% (95% CI, 22.2-67.7%) of fetuses, while none of the affected cases experienced morbidity and survivors were free of neurological complications. Of pregnancies undergoing selective reduction, IUD of the cotwin occurred in 5.0% (95% CI, 0.03-20.5%) and NND in 3.7% (95% CI, 0.2-11.1%), and 90.6% (95% CI, 42.3-94.3%) of surviving cotwins were free from neurological complications. In pregnancies complicated by Type-III sFGR managed expectantly, IUD occurred in 13.2% (95% CI, 7.2-20.5%) and NND in 6.8% (95% CI, 0.7-18.6%) of fetuses, and 61.9% (95% CI, 38.4-81.9%) of twins had intact survival. In pregnancies complicated by Type-III sFGR treated with laser therapy, IUD occurred in 32.9% (95% CI, 20.9-46.2%) of fetuses and all surviving twins were without neurological complications. Finally, in pregnancies with Type-III sFGR treated with selective reduction, NND occurred in 5.2% (95% CI, 0.8-12.8%) of cotwins and 98.8% (95% CI, 93.9-99.9%) had intact survival.Conclusion: Type-I sFGR is characterized by good perinatal outcome when managed expectantly, which represents the most reasonable management strategy for the large majority of affected cases. Pregnancies complicated by Type-II or -III sFGR treated with fetoscopic laser ablation have a higher rate of mortality but lower rate of morbidity compared with those managed expectantly, supporting the use of fetal therapy at gestations remote from neonatal viability. Data on outcome following selective reduction are scarce. In view of the lack of evidence from randomized controlled trials, prenatal management of sFGR should be individualized according to gestational age at diagnosis, severity of growth discordance and magnitude of Doppler anomalies. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd. [ABSTRACT FROM AUTHOR]- Published
- 2019
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22. 'Just-flow' visualization of aortic arch in fetuses ≤ 16 weeks.
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Sileo, F. G., Carvalho, J. S., Sileo, Filomena Giulia, and Carvalho, Julene S
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THORACIC aorta ,SECOND trimester of pregnancy ,FETAL echocardiography ,FETUS ,VISUALIZATION - Abstract
Fetal echocardiography in first and early second trimester of pregnancy (≤16 weeks) is now considered an integral part of fetal cardiology in centres with expertise in this area 1,2 . Early echocardiography was complete in 71% of fetuses at 12-16 weeks 3 and the aortic arch seen in axial views in >90% fetuses at 12-13 weeks 4 . This article is protected by copyright. All rights reserved. [ABSTRACT FROM AUTHOR]
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- 2019
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23. Role of prenatal magnetic resonance imaging in fetuses with isolated severe ventriculomegaly at neurosonography: A multicenter study
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Paolo Volpe, Sara Tinari, Vincenzo Berghella, Francesca Ormitti, Francesco Toni, Olav Bennike Bjørn Petersen, Erich Cosmi, Ludovica Oronzi, Alberto Galindo, Marco De Santis, José Morales-Roselló, Lucia Manganaro, Marcella Pellegrino, Gabriela Loscalzo, Giada Ercolani, Lorenzo Pinelli, Giovanni Scambia, Asma Khalil, Flora Murru, Federico Prefumo, Puk Sandager, Daniele Di Mascio, Tamara Stampalija, F. Forlani, Giuseppe Rizzo, Ignacio Herraiz, Cecilia Parazzini, A. Lanzone, Giulia Masini, Gabriele Saccone, Luigi Carbone, Ilaria Giangiordano, Danilo Buca, Marco Liberati, Gianluigi Pilu, Ilenia Mappa, Elena Trincia, Tiziana Frusca, Silvia Visentin, Tullio Ghi, Luigi Nappi, Mariano Lanna, Francesco D'Antonio, Claudiana Olivieri, Christoph Lees, Sandra Ciulla, Ilaria Fantasia, Cecilia Acuti Martellucci, Maria Elena Flacco, Valentina D'Ambrosio, Giuseppe Maria Maruotti, Andrea Dall'Asta, Marco Di Maurizio, Massimo Caulo, Fulvio Zullo, Lamberto Manzoli, Cecilia Villalain, Olivia Mendez Quintero, Ludovico Muzii, Filomena Giulia Sileo, Raquel Garcia, Antonella Giancotti, Lucia Pasquini, Gabriella Bracalente, Roberto Brunelli, Amanda Antonelli, Alice D'Amico, Lisa Neerup, Ginevra Salsi, Di Mascio, D., Khalil, A., Pilu, G., Rizzo, G., Caulo, M., Liberati, M., Giancotti, A., Lees, C., Volpe, P., Buca, D., Oronzi, L., D'Amico, A., Tinari, S., Stampalija, T., Fantasia, I., Pasquini, L., Masini, G., Brunelli, R., D'Ambrosio, V., Muzii, L., Manganaro, L., Antonelli, A., Ercolani, G., Ciulla, S., Saccone, G., Maruotti, G. M., Carbone, L., Zullo, F., Olivieri, C., Ghi, T., Frusca, T., Dall'Asta, A., Visentin, S., Cosmi, E., Forlani, F., Galindo, A., Villalain, C., Herraiz, I., Sileo, F. G., Mendez Quintero, O., Salsi, G., Bracalente, G., Morales-Rosello, J., Loscalzo, G., Pellegrino, M., De Santis, M., Lanzone, A., Parazzini, C., Lanna, M., Ormitti, F., Toni, F., Murru, F., Di Maurizio, M., Trincia, E., Garcia, R., Bennike Bjorn Petersen, O., Neerup, L., Sandager, P., Prefumo, F., Pinelli, L., Mappa, I., Acuti Martellucci, C., Flacco, M. E., Manzoli, L., Giangiordano, I., Nappi, L., Scambia, G., Berghella, V., D'Antonio, F., Di Mascio, Daniele, Khalil, Asma, Pilu, Gianluigi, Rizzo, Giuseppe, Caulo, Massimo, Liberati, Marco, Giancotti, Antonella, Lees, Christoph, Volpe, Paolo, Buca, Danilo, Oronzi, Ludovica, D'Amico, Alice, Tinari, Sara, Stampalija, Tamara, Fantasia, Ilaria, Pasquini, Lucia, Masini, Giulia, Brunelli, Roberto, D'Ambrosio, Valentina, Muzii, Ludovico, Manganaro, Lucia, Antonelli, Amanda, Ercolani, Giada, Ciulla, Sandra, Saccone, Gabriele, Maruotti, Giuseppe Maria, Carbone, Luigi, Zullo, Fulvio, Olivieri, Claudiana, Ghi, Tullio, Frusca, Tiziana, Dall'Asta, Andrea, Visentin, Silvia, Cosmi, Erich, Forlani, Francesco, Galindo, Alberto, Villalain, Cecilia, Herraiz, Ignacio, Sileo, Filomena Giulia, Quintero, Olivia Mendez, Salsi, Ginevra, Bracalente, Gabriella, Morales-Roselló, José, Loscalzo, Gabriela, Pellegrino, Marcella, De Santis, Marco, Lanzone, Antonio, Parazzini, Cecilia, Lanna, Mariano, Ormitti, Francesca, Toni, Francesco, Murru, Flora, Di Maurizio, Marco, Trincia, Elena, Garcia, Raquel, Petersen, Olav Bennike Bjørn, Neerup, Lisa, Sandager, Puk, Prefumo, Federico, Pinelli, Lorenzo, Mappa, Ilenia, Martellucci, Cecilia Acuti, Flacco, Maria Elena, Manzoli, Lamberto, Giangiordano, Ilaria, Nappi, Luigi, Scambia, Giovanni, Berghella, Vincenzo, and D'Antonio, Francesco
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medicine.medical_specialty ,Central nervous system ,Fetal magnetic resonance imaging ,Fetal ultrasound ,MRI ,Neurosonography ,Prenatal diagnosis ,Ventriculomegaly ,Prenatal diagnosi ,central nervous system ,fetal magnetic resonance imaging ,fetal ultrasound ,neurosonography ,prenatal diagnosis ,ventriculomegaly ,Ultrasonography, Prenatal ,NO ,Cohort Studies ,Lesion ,Central nervous system, Fetal magnetic resonance imaging, Fetal ultrasound, MRI, Neurosonography, Prenatal diagnosis, Ventriculomegaly ,Fetus ,Pregnancy ,Humans ,Medicine ,ventriculomegaly, central nervous system, fetal magnetic resonance imaging, MRI, fetal ultrasound, neurosonography, prenatal diagnosis ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Obstetrics and Gynecology ,Gestational age ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,Reproductive Medicine ,Settore MED/40 ,Gestation ,Female ,Radiology ,medicine.symptom ,business ,Hydrocephalus - Abstract
Objective: The aim of this study was to report the rate of additional anomalies detected exclusively at prenatal magnetic resonance imaging (MRI) in fetuses with isolated severe ventriculomegaly undergoing neurosonography. Method: Multicenter, retrospective, cohort study involving 20 referral fetal medicine centers in Italy, United Kingdom, Spain and Denmark. Inclusion criteria were fetuses affected by isolated severe ventriculomegaly (≥15 mm), defined as ventriculomegaly with normal karyotype and no other additional central nervous system (CNS) and extra-CNS anomalies on ultrasound. In all cases, a multiplanar assessment of fetal brain as suggested by ISUOG guidelines on fetal neurosonography had been performed. The primary outcome was the rate of additional CNS anomalies detected exclusively at fetal MRI within two weeks from neurosonography. Subgroup analyses according to gestational age at MRI (
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- 2021
24. Role of prenatal magnetic resonance imaging in fetuses with isolated mild or moderate ventriculomegaly in the era of neurosonography: international multicenter study
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Vincenzo Berghella, Giuseppe Maria Maruotti, Francesco Toni, Gabriella Bracalente, José Morales-Roselló, Ilaria Fantasia, Karen Melchiorre, Ginevra Salsi, Giovanni Scambia, Gabriella Meccariello, Lucia Manganaro, Marco Di Maurizio, Federico Prefumo, Pierluigi Benedetti Panici, Tamara Stampalija, Christoph Lees, Giuseppe Rizzo, Giada Ercolani, Gianluigi Pilu, Paolo Volpe, Francesco D'Antonio, Basky Thilaganathan, Asma Khalil, Tullio Ghi, Alessandra Familiari, Luisa D'Oria, Luigi Nappi, Roberto Brunelli, Claudio Celentano, Marco De Santis, Ilaria Giangiordano, Danilo Buca, S. Buongiorno, Francesca Ormitti, Tiziana Frusca, Giulia Masini, Fulvio Zullo, Nicola Volpe, Luciana Mastricci, Laura Sarno, Lorenzo Vasciaveo, Massimo Caulo, Lucia Pasquini, Valentina D'Ambrosio, Maria Elena Flacco, Giulia Luise, Lamberto Manzoli, Gabriele Saccone, Antonio Lanzone, Filomena Giulia Sileo, Emma Bertucci, Antonella Giancotti, Amanda Antonelli, Gabriela Loscalzo, Luigi Carbone, Massimo Gregori, Daniele Di Mascio, Claudiana Olivieri, Marco Liberati, Andrea Dall'Asta, Lorenzo Pinelli, Di Mascio D., Khalil A., Thilaganathan B., Rizzo G., Buca D., Liberati M., Celentano C., Melchiorre K., Caulo M., Pilu G., Salsi G., Toni F., Stampalija T., Fantasia I., Luise G., Gregori M., Volpe P., Olivieri C., Giancotti A., D'Ambrosio V., Brunelli R., Panici P.B., Manganaro L., Antonelli A., Ercolani G., Pasquini L., Masini G., Di Maurizio M., Lees C., Bracalente G., Morales-Rosello J., Loscalzo G., Saccone G., Carbone L., Sarno L., Maruotti G.M., Zullo F., Ghi T., Frusca T., Dall'Asta A., Volpe N., Ormitti F., Buongiorno S., De Santis M., D'Oria L., Lanzone A., Prefumo F., Pinelli L., Bertucci E., Sileo F.G., Flacco M.E., Manzoli L., Giangiordano I., Mastricci L., Meccariello G., Vasciaveo L., Nappi L., Familiari A., Scambia G., Berghella V., D'Antonio F., Di Mascio, Daniele, Khalil, Asma, Thilaganathan, Basky, Rizzo, Giuseppe, Buca, Danilo, Liberati, Marco, Celentano, Claudio, Melchiorre, Karen, Caulo, Massimo, Pilu, Gianluigi, Salsi, Ginevra, Toni, Francesco, Stampalija, Tamara, Fantasia, Ilaria, Luise, Giulia, Gregori, Massimo, Volpe, Paolo, Olivieri, Claudiana, Giancotti, Antonella, D'Ambrosio, Valentina, Brunelli, Roberto, Benedetti Panici, Pierluigi, Manganaro, Lucia, Antonelli, Amanda, Ercolani, Giada, Pasquini, Lucia, Masini, Giulia, Di Maurizio, Marco, Lees, Christoph, Bracalente, Gabriella, Morales‐roselló, José, Loscalzo, Gabriela, Saccone, Gabriele, Carbone, Luigi, Sarno, Laura, Maruotti, GIUSEPPE MARIA, Zullo, Fulvio, Ghi, Tullio, Frusca, Tiziana, Dall'Asta, Andrea, Volpe, Nicola, Ormitti, Francesca, Buongiorno, Silvia, De Santis, Marco, D'Oria, Luisa, Lanzone, Antonio, Prefumo, Federico, Pinelli, Lorenzo, Bertucci, Emma, Giulia Sileo, Filomena, Elena Flacco, Maria, Manzoli, Lamberto, Giangiordano, Ilaria, Mastricci, Luciana, Meccariello, Gabriella, Vasciaveo, Lorenzo, Nappi, Luigi, Familiari, Alessandra, Scambia, Giovanni, Berghella, Vincenzo, D'Antonio, Francesco, Mascio, Daniele Di, Panici, Pierluigi Benedetti, Maruotti, Giuseppe Maria, Sileo, Filomena Giulia, and Flacco, Maria Elena
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Fetal magnetic resonance imaging ,central nervous system ,fetal magnetic resonance imaging ,fetal ultrasound ,MRI ,neurosonography ,prenatal diagnosis ,ventriculomegaly ,Adult ,Cohort Studies ,Europe ,Female ,Gestational Age ,Humans ,Hydrocephalus ,Predictive Value of Tests ,Pregnancy ,Retrospective Studies ,Magnetic Resonance Imaging ,Prenatal Diagnosis ,medicine.medical_specialty ,Socio-culturale ,Fetal brain ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,Fetus ,prenatal diagnosi ,030219 obstetrics & reproductive medicine ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Obstetrics and Gynecology ,Magnetic resonance imaging ,General Medicine ,medicine.disease ,Settore MED/40 - GINECOLOGIA E OSTETRICIA ,Reproductive Medicine ,Multicenter study ,embryonic structures ,Radiology ,business ,Ventriculomegaly - Abstract
Objectives: To assess the role of fetal magnetic resonance imaging (MRI) in detecting associated anomalies in fetuses presenting with mild or moderate isolated ventriculomegaly (VM) undergoing multiplanar ultrasound evaluation of the fetal brain. Methods: This was a multicenter, retrospective, cohort study involving 15 referral fetal medicine centers in Italy, the UK and Spain. Inclusion criteria were fetuses affected by isolated mild (ventricular atrial diameter, 10.0–11.9 mm) or moderate (ventricular atrial diameter, 12.0–14.9 mm) VM on ultrasound, defined as VM with normal karyotype and no other additional central nervous system (CNS) or extra-CNS anomalies on ultrasound, undergoing detailed assessment of the fetal brain using a multiplanar approach as suggested by the International Society of Ultrasound in Obstetrics and Gynecology guidelines for the fetal neurosonogram, followed by fetal MRI. The primary outcome of the study was to report the incidence of additional CNS anomalies detected exclusively on prenatal MRI and missed on ultrasound, while the secondary aim was to estimate the incidence of additional anomalies detected exclusively after birth and missed on prenatal imaging (ultrasound and MRI). Subgroup analysis according to gestational age at MRI (< 24 vs ≥ 24 weeks), laterality of VM (unilateral vs bilateral) and severity of dilatation (mild vs moderate VM) were also performed. Results: Five hundred and fifty-six fetuses with a prenatal diagnosis of isolated mild or moderate VM on ultrasound were included in the analysis. Additional structural anomalies were detected on prenatal MRI and missed on ultrasound in 5.4% (95% CI, 3.8–7.6%) of cases. When considering the type of anomaly, supratentorial intracranial hemorrhage was detected on MRI in 26.7% of fetuses, while polymicrogyria and lissencephaly were detected in 20.0% and 13.3% of cases, respectively. Hypoplasia of the corpus callosum was detected on MRI in 6.7% of cases, while dysgenesis was detected in 3.3%. Fetuses with an associated anomaly detected only on MRI were more likely to have moderate than mild VM (60.0% vs 17.7%; P < 0.001), while there was no significant difference in the proportion of cases with bilateral VM between the two groups (P = 0.2). Logistic regression analysis showed that lower maternal body mass index (adjusted odds ratio (aOR), 0.85 (95% CI, 0.7–0.99); P = 0.030), the presence of moderate VM (aOR, 5.8 (95% CI, 2.6–13.4); P < 0.001) and gestational age at MRI ≥ 24 weeks (aOR, 4.1 (95% CI, 1.1–15.3); P = 0.038) were associated independently with the probability of detecting an associated anomaly on MRI. Associated anomalies were detected exclusively at birth and missed on prenatal imaging in 3.8% of cases. Conclusions: The incidence of an associated fetal anomaly missed on ultrasound and detected only on fetal MRI in fetuses with isolated mild or moderate VM undergoing neurosonography is lower than that reported previously. The large majority of these anomalies are difficult to detect on ultrasound. The findings from this study support the practice of MRI assessment in every fetus with a prenatal diagnosis of VM, although parents can be reassured of the low risk of an associated anomaly when VM is isolated on neurosonography. Copyright © 2020 ISUOG. Published by John Wiley & Sons Ltd.
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- 2020
25. The Jellyfish Sign: A New Sonographic Cervical Marker to Predict Maternal Morbidity in Abnormally Invasive Placenta Previa.
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Bertucci E, Sileo FG, Grandi G, Fenu V, Cani C, Mancini L, Mataca E, and Facchinetti F
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- Cesarean Section, Female, Humans, Pregnancy, Retrospective Studies, Cervix Uteri pathology, Placenta Accreta diagnosis, Placenta Previa diagnosis
- Abstract
Purpose: To investigate the value of a new cervical sonographic sign, called the jellyfish sign (JS), for predicting the risk of maternal morbidity in cases of abnormally invasive placenta (AIP) previa totalis., Materials and Methods: Retrospective evaluation of transvaginal (TV) and transabdominal (TA) scans performed in all singleton pregnancies with placenta previa totalis. JS, i. e. the absence of the normal linear demarcation between the placenta previa and the cervix, was evaluated by TV scans. The presence/severity of AIP and outcomes of maternal morbidity were related to this sign., Results: JS was noted in 8/39 (20.5 %) patients. The two analyzed groups, i. e. with and without JS, were similar. The specificity of JS in AIP diagnosis, histological findings of accreta/increta/percreta, need for caesarean hysterectomy or blood loss > 2000 ml ranges between 92 % and 96.2 %, with the PPV and NPV ranging between 71.4 % and 85.7 % and 61.3 % and 80.6 %, respectively. The JS group had a significant increase in blood loss (ml) (p = 0.003), transfusions (%) (p = 0.016), red blood cells (p = 0.002) and plasma (p = 0.002), admission to an postoperative intensive care unit (ICU) (%) (p = 0.002), hospitalization length (p < 0.001) and the need of cesarean hysterectomy (%) (p < 0.001). JS was independently correlated to cesarean hysterectomy (OR 25.6; 95 % CI 2.0:322.3, p = 0.012) and blood loss > 2000 ml (OR 16.6; 95 % CI 1.5:180.1, p = 0.021) also in a logistic regression model., Conclusion: JS is useful in predicting the increase in maternal morbidity: massive transfusion, admission to the ICU and cesarean hysterectomy related to intraoperative bleeding in patients with a previa AIP., Competing Interests: Disclosure The authors report no conflicts of interest in this work., (© Georg Thieme Verlag KG Stuttgart · New York.)
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- 2019
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