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1. Human neocortical expansion involves glutamatergic neuron diversification

Author

Berg, Jim, Sorensen, Staci A., Ting, Jonathan T., Miller, Jeremy A., Chartrand, Thomas, Buchin, Anatoly, Bakken, Trygve E., Budzillo, Agata, Dee, Nick, Ding, Song-Lin, Gouwens, Nathan W., Hodge, Rebecca D., Kalmbach, Brian, Lee, Changkyu, Lee, Brian R., Alfiler, Lauren, Baker, Katherine, Barkan, Eliza, Beller, Allison, Berry, Kyla, Bertagnolli, Darren, Bickley, Kris, Bomben, Jasmine, Braun, Thomas, Brouner, Krissy, Casper, Tamara, Chong, Peter, Crichton, Kirsten, Dalley, Rachel, de Frates, Rebecca, Desta, Tsega, Lee, Samuel Dingman, D’Orazi, Florence, Dotson, Nadezhda, Egdorf, Tom, Enstrom, Rachel, Farrell, Colin, Feng, David, Fong, Olivia, Furdan, Szabina, Galakhova, Anna A., Gamlin, Clare, Gary, Amanda, Glandon, Alexandra, Goldy, Jeff, Gorham, Melissa, Goriounova, Natalia A., Gratiy, Sergey, Graybuck, Lucas, Gu, Hong, Hadley, Kristen, Hansen, Nathan, Heistek, Tim S., Henry, Alex M., Heyer, Djai B., Hill, DiJon, Hill, Chris, Hupp, Madie, Jarsky, Tim, Kebede, Sara, Keene, Lisa, Kim, Lisa, Kim, Mean-Hwan, Kroll, Matthew, Latimer, Caitlin, Levi, Boaz P., Link, Katherine E., Mallory, Matthew, Mann, Rusty, Marshall, Desiree, Maxwell, Michelle, McGraw, Medea, McMillen, Delissa, Melief, Erica, Mertens, Eline J., Mezei, Leona, Mihut, Norbert, Mok, Stephanie, Molnar, Gabor, Mukora, Alice, Ng, Lindsay, Ngo, Kiet, Nicovich, Philip R., Nyhus, Julie, Olah, Gaspar, Oldre, Aaron, Omstead, Victoria, Ozsvar, Attila, Park, Daniel, Peng, Hanchuan, Pham, Trangthanh, Pom, Christina A., Potekhina, Lydia, Rajanbabu, Ramkumar, Ransford, Shea, Reid, David, Rimorin, Christine, Ruiz, Augustin, Sandman, David, Sulc, Josef, Sunkin, Susan M., Szafer, Aaron, Szemenyei, Viktor, Thomsen, Elliot R., Tieu, Michael, Torkelson, Amy, Trinh, Jessica, Tung, Herman, Wakeman, Wayne, Waleboer, Femke, Ward, Katelyn, Wilbers, René, Williams, Grace, Yao, Zizhen, Yoon, Jae-Geun, Anastassiou, Costas, Arkhipov, Anton, Barzo, Pal, Bernard, Amy, Cobbs, Charles, de Witt Hamer, Philip C., Ellenbogen, Richard G., Esposito, Luke, Ferreira, Manuel, Gwinn, Ryder P., Hawrylycz, Michael J., Hof, Patrick R., Idema, Sander, Jones, Allan R., Keene, C. Dirk, Ko, Andrew L., Murphy, Gabe J., Ng, Lydia, Ojemann, Jeffrey G., Patel, Anoop P., Phillips, John W., Silbergeld, Daniel L., Smith, Kimberly, Tasic, Bosiljka, Yuste, Rafael, Segev, Idan, de Kock, Christiaan P. J., Mansvelder, Huibert D., Tamas, Gabor, Zeng, Hongkui, Koch, Christof, and Lein, Ed S.

Published
2021
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4. Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex

Author

Lee, Brian R., primary, Dalley, Rachel, additional, Miller, Jeremy A., additional, Chartrand, Thomas, additional, Close, Jennie, additional, Mann, Rusty, additional, Mukora, Alice, additional, Ng, Lindsay, additional, Alfiler, Lauren, additional, Baker, Katherine, additional, Bertagnolli, Darren, additional, Brouner, Krissy, additional, Casper, Tamara, additional, Csajbok, Eva, additional, Donadio, Nicholas, additional, Driessens, Stan L.W., additional, Egdorf, Tom, additional, Enstrom, Rachel, additional, Galakhova, Anna A., additional, Gary, Amanda, additional, Gelfand, Emily, additional, Goldy, Jeff, additional, Hadley, Kristen, additional, Heistek, Tim S., additional, Hill, Dijon, additional, Hou, Wen-Hsien, additional, Johansen, Nelson, additional, Jorstad, Nik, additional, Kim, Lisa, additional, Kocsis, Agnes Katalin, additional, Kruse, Lauren, additional, Kunst, Michael, additional, León, Gabriela, additional, Long, Brian, additional, Mallory, Matthew, additional, Maxwell, Michelle, additional, McGraw, Medea, additional, McMillen, Delissa, additional, Melief, Erica J., additional, Molnar, Gabor, additional, Mortrud, Marty T., additional, Newman, Dakota, additional, Nyhus, Julie, additional, Opitz-Araya, Ximena, additional, Ozsvár, Attila, additional, Pham, Trangthanh, additional, Pom, Alice, additional, Potekhina, Lydia, additional, Rajanbabu, Ram, additional, Ruiz, Augustin, additional, Sunkin, Susan M., additional, Szöts, Ildikó, additional, Taskin, Naz, additional, Thyagarajan, Bargavi, additional, Tieu, Michael, additional, Trinh, Jessica, additional, Vargas, Sara, additional, Vumbaco, David, additional, Waleboer, Femke, additional, Walling-Bell, Sarah, additional, Weed, Natalie, additional, Williams, Grace, additional, Wilson, Julia, additional, Yao, Shenqin, additional, Zhou, Thomas, additional, Barzó, Pál, additional, Bakken, Trygve, additional, Cobbs, Charles, additional, Dee, Nick, additional, Ellenbogen, Richard G., additional, Esposito, Luke, additional, Ferreira, Manuel, additional, Gouwens, Nathan W., additional, Grannan, Benjamin, additional, Gwinn, Ryder P., additional, Hauptman, Jason S., additional, Hodge, Rebecca, additional, Jarsky, Tim, additional, Keene, C. Dirk, additional, Ko, Andrew L., additional, Korshoej, Anders Rosendal, additional, Levi, Boaz P., additional, Meier, Kaare, additional, Ojemann, Jeffrey G., additional, Patel, Anoop, additional, Ruzevick, Jacob, additional, Silbergeld, Daniel L., additional, Smith, Kimberly, additional, Sørensen, Jens Christian, additional, Waters, Jack, additional, Zeng, Hongkui, additional, Berg, Jim, additional, Capogna, Marco, additional, Goriounova, Natalia A., additional, Kalmbach, Brian, additional, de Kock, Christiaan P.J., additional, Mansvelder, Huib D., additional, Sorensen, Staci A., additional, Tamas, Gabor, additional, Lein, Ed S., additional, and Ting, Jonathan T., additional

Published
2023
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5. Author Correction: Human neocortical expansion involves glutamatergic neuron diversification

Author

Berg, Jim, Sorensen, Staci A., Ting, Jonathan T., Miller, Jeremy A., Chartrand, Thomas, Buchin, Anatoly, Bakken, Trygve E., Budzillo, Agata, Dee, Nick, Ding, Song-Lin, Gouwens, Nathan W., Hodge, Rebecca D., Kalmbach, Brian, Lee, Changkyu, Lee, Brian R., Alfiler, Lauren, Baker, Katherine, Barkan, Eliza, Beller, Allison, Berry, Kyla, Bertagnolli, Darren, Bickley, Kris, Bomben, Jasmine, Braun, Thomas, Brouner, Krissy, Casper, Tamara, Chong, Peter, Crichton, Kirsten, Dalley, Rachel, de Frates, Rebecca, Desta, Tsega, Lee, Samuel Dingman, D’Orazi, Florence, Dotson, Nadezhda, Egdorf, Tom, Enstrom, Rachel, Farrell, Colin, Feng, David, Fong, Olivia, Furdan, Szabina, Galakhova, Anna A., Gamlin, Clare, Gary, Amanda, Glandon, Alexandra, Goldy, Jeff, Gorham, Melissa, Goriounova, Natalia A., Gratiy, Sergey, Graybuck, Lucas, Gu, Hong, Hadley, Kristen, Hansen, Nathan, Heistek, Tim S., Henry, Alex M., Heyer, Djai B., Hill, DiJon, Hill, Chris, Hupp, Madie, Jarsky, Tim, Kebede, Sara, Keene, Lisa, Kim, Lisa, Kim, Mean-Hwan, Kroll, Matthew, Latimer, Caitlin, Levi, Boaz P., Link, Katherine E., Mallory, Matthew, Mann, Rusty, Marshall, Desiree, Maxwell, Michelle, McGraw, Medea, McMillen, Delissa, Melief, Erica, Mertens, Eline J., Mezei, Leona, Mihut, Norbert, Mok, Stephanie, Molnar, Gabor, Mukora, Alice, Ng, Lindsay, Ngo, Kiet, Nicovich, Philip R., Nyhus, Julie, Olah, Gaspar, Oldre, Aaron, Omstead, Victoria, Ozsvar, Attila, Park, Daniel, Peng, Hanchuan, Pham, Trangthanh, Pom, Christina A., Potekhina, Lydia, Rajanbabu, Ramkumar, Ransford, Shea, Reid, David, Rimorin, Christine, Ruiz, Augustin, Sandman, David, Sulc, Josef, Sunkin, Susan M., Szafer, Aaron, Szemenyei, Viktor, Thomsen, Elliot R., Tieu, Michael, Torkelson, Amy, Trinh, Jessica, Tung, Herman, Wakeman, Wayne, Waleboer, Femke, Ward, Katelyn, Wilbers, René, Williams, Grace, Yao, Zizhen, Yoon, Jae-Geun, Anastassiou, Costas, Arkhipov, Anton, Barzo, Pal, Bernard, Amy, Cobbs, Charles, de Witt Hamer, Philip C., Ellenbogen, Richard G., Esposito, Luke, Ferreira, Manuel, Gwinn, Ryder P., Hawrylycz, Michael J., Hof, Patrick R., Idema, Sander, Jones, Allan R., Keene, C. Dirk, Ko, Andrew L., Murphy, Gabe J., Ng, Lydia, Ojemann, Jeffrey G., Patel, Anoop P., Phillips, John W., Silbergeld, Daniel L., Smith, Kimberly, Tasic, Bosiljka, Yuste, Rafael, Segev, Idan, de Kock, Christiaan P. J., Mansvelder, Huibert D., Tamas, Gabor, Zeng, Hongkui, Koch, Christof, and Lein, Ed S.

Published
2022
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7. Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex

Author

Kim, Mean-Hwan, primary, Radaelli, Cristina, additional, Thomsen, Elliot R, additional, Monet, Deja, additional, Chartrand, Thomas, additional, Jorstad, Nikolas L, additional, Mahoney, Joseph T, additional, Taormina, Michael J, additional, Long, Brian, additional, Baker, Katherine, additional, Bakken, Trygve E, additional, Campagnola, Luke, additional, Casper, Tamara, additional, Clark, Michael, additional, Dee, Nick, additional, D'Orazi, Florence, additional, Gamlin, Clare, additional, Kalmbach, Brian E, additional, Kebede, Sara, additional, Lee, Brian R, additional, Ng, Lindsay, additional, Trinh, Jessica, additional, Cobbs, Charles, additional, Gwinn, Ryder P, additional, Keene, C Dirk, additional, Ko, Andrew L, additional, Ojemann, Jeffrey G, additional, Silbergeld, Daniel L, additional, Sorensen, Staci A, additional, Berg, Jim, additional, Smith, Kimberly A, additional, Nicovich, Philip R, additional, Jarsky, Tim, additional, Zeng, Hongkui, additional, Ting, Jonathan T, additional, Levi, Boaz P, additional, and Lein, Ed, additional

Published
2023
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8. Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex

Author

Chartrand, Thomas, Dalley, Rachel, Close, Jennie, Goriounova, Natalia A., Lee, Brian R., Mann, Rusty, Miller, Jeremy A., Molnar, Gabor, Mukora, Alice, Alfiler, Lauren, Baker, Katherine, Bakken, Trygve E., Berg, Jim, Bertagnolli, Darren, Braun, Thomas, Brouner, Krissy, Casper, Tamara, Csajbok, Eva Adrienn, Dee, Nick, Egdorf, Tom, Enstrom, Rachel, Galakhova, Anna A., Gary, Amanda, Gelfand, Emily, Goldy, Jeff, Hadley, Kristen, Heistek, Tim S., Hill, Di Jon, Jorstad, Nik, Kim, Lisa, Kocsis, Agnes Katalin, Kruse, Lauren, Kunst, Michael, Leon, Gabriela, Long, Brian, Mallory, Matthew, McGraw, Medea, McMillen, Delissa, Melief, Erica J., Mihut, Norbert, Ng, Lindsay, Nyhus, Julie, Oláh, Gáspár, Ozsvár, Attila, Omstead, Victoria, Peterfi, Zoltan, Pom, Alice, Potekhina, Lydia, Rajanbabu, Ramkumar, Rozsa, Marton, Ruiz, Augustin, Sandle, Joanna, Sunkin, Susan M., Szots, Ildiko, Tieu, Michael, Toth, Martin, Trinh, Jessica, Vargas, Sara, Vumbaco, David, Williams, Grace, Wilson, Julia, Yao, Zizhen, Barzo, Pal, Cobbs, Charles, Ellenbogen, Richard G., Esposito, Luke, Ferreira, Manuel, Gouwens, Nathan W., Grannan, Benjamin, Gwinn, Ryder P., Hauptman, Jason S., Jarsky, Tim, Keene, C. Dirk, Ko, Andrew L., Koch, Christof, Ojemann, Jeffrey G., Patel, Anoop, Ruzevick, Jacob, Silbergeld, Daniel L., Smith, Kimberly, Sorensen, Staci A., Tasic, Bosiljka, Ting, Jonathan T., Waters, Jack, de Kock, Christiaan P.J., Mansvelder, Huib D., Tamas, Gabor, Zeng, Hongkui, Kalmbach, Brian, Lein, Ed S., Chartrand, Thomas, Dalley, Rachel, Close, Jennie, Goriounova, Natalia A., Lee, Brian R., Mann, Rusty, Miller, Jeremy A., Molnar, Gabor, Mukora, Alice, Alfiler, Lauren, Baker, Katherine, Bakken, Trygve E., Berg, Jim, Bertagnolli, Darren, Braun, Thomas, Brouner, Krissy, Casper, Tamara, Csajbok, Eva Adrienn, Dee, Nick, Egdorf, Tom, Enstrom, Rachel, Galakhova, Anna A., Gary, Amanda, Gelfand, Emily, Goldy, Jeff, Hadley, Kristen, Heistek, Tim S., Hill, Di Jon, Jorstad, Nik, Kim, Lisa, Kocsis, Agnes Katalin, Kruse, Lauren, Kunst, Michael, Leon, Gabriela, Long, Brian, Mallory, Matthew, McGraw, Medea, McMillen, Delissa, Melief, Erica J., Mihut, Norbert, Ng, Lindsay, Nyhus, Julie, Oláh, Gáspár, Ozsvár, Attila, Omstead, Victoria, Peterfi, Zoltan, Pom, Alice, Potekhina, Lydia, Rajanbabu, Ramkumar, Rozsa, Marton, Ruiz, Augustin, Sandle, Joanna, Sunkin, Susan M., Szots, Ildiko, Tieu, Michael, Toth, Martin, Trinh, Jessica, Vargas, Sara, Vumbaco, David, Williams, Grace, Wilson, Julia, Yao, Zizhen, Barzo, Pal, Cobbs, Charles, Ellenbogen, Richard G., Esposito, Luke, Ferreira, Manuel, Gouwens, Nathan W., Grannan, Benjamin, Gwinn, Ryder P., Hauptman, Jason S., Jarsky, Tim, Keene, C. Dirk, Ko, Andrew L., Koch, Christof, Ojemann, Jeffrey G., Patel, Anoop, Ruzevick, Jacob, Silbergeld, Daniel L., Smith, Kimberly, Sorensen, Staci A., Tasic, Bosiljka, Ting, Jonathan T., Waters, Jack, de Kock, Christiaan P.J., Mansvelder, Huib D., Tamas, Gabor, Zeng, Hongkui, Kalmbach, Brian, and Lein, Ed S.

Abstract

Neocortical layer 1 (L1) is a site of convergence between pyramidal-neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary expansion of human neocortex is marked by distinctive pyramidal neurons with extensive L1 branching, but whether L1 interneurons are similarly diverse is underexplored. Using Patch-seq recordings from human neurosurgical tissue, we identified four transcriptomic subclasses with mouse L1 homologs, along with distinct subtypes and types unmatched in mouse L1. Subclass and subtype comparisons showed stronger transcriptomic differences in human L1 and were correlated with strong morphoelectric variability along dimensions distinct from mouse L1 variability. Accompanied by greater layer thickness and other cytoarchitecture changes, these findings suggest that L1 has diverged in evolution, reflecting the demands of regulating the expanded human neocortical circuit.

Published
2023
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11. Contributors

Author

Abecassis, Isaac Josh, primary, Agarwal, Vijay, additional, Agarwalla, Pankaj K., additional, Ahuja, Christopher S., additional, Alalade, Andrew Folusho, additional, Alli, Saira, additional, Aquilina, Kristian, additional, Armonda, Rocco A., additional, Baird, Lissa, additional, Bales, James W., additional, Bambakidis, Nicholas C., additional, Barrow, Daniel L., additional, Bauer, David F., additional, Beecher, Jeffrey S., additional, Bell, Randy S, additional, Belli, Antonio, additional, Benzel, Edward C., additional, Bonow, Robert H., additional, Bracale, Umberto Marcello, additional, Browd, Samuel R., additional, Bulsara, Ketan, additional, Cadotte, David W., additional, Cappabianca, Paolo, additional, Cavallo, Luigi Maria, additional, Chan, Alvin Y., additional, Chen, Roc Peng, additional, Chiarelli, Peter A., additional, Choudhri, Omar, additional, Chowdhary, Michelle, additional, Chu, Jason, additional, Cirivello, Michael J., additional, de Araújo Coimbra, Pablo Picasso, additional, Collins, Kelly L., additional, Daartz, Juliane, additional, de Divitiis, Oreste, additional, Deinsberger, Wolfgang, additional, Dekker, Simone E., additional, Dewan, Michael C., additional, Di Maio, Salvatore, additional, Ding, Dale, additional, Ellenbogen, Richard G., additional, Ene, Chibawanye, additional, Fehlings, Michael, additional, de Carvalho, Flávio Leitão, additional, Fink, James R., additional, Fink, Kathleen R. Tozer, additional, Fridley, Jared, additional, Ghobrial, George M., additional, Gleeson, Michael, additional, Goel, Atul, additional, Gokaslan, Ziya L., additional, Goodrich, James Tait, additional, Grant, Gerald A., additional, Gross, Bradley A., additional, Gruss, Joseph, additional, Halasz, Lia, additional, Hanak, Brian W., additional, Hankinson, Todd C., additional, Harrop, James S., additional, Heilman, Carl B., additional, Heller, Robert S., additional, Hoffer, S. Alan, additional, Hofstetter, Christoph P., additional, Hyam, Jonathan A., additional, Impastato, Kate, additional, Isik, Semra, additional, James, Greg, additional, Jha, R. Tushar, additional, Jones, Kristen E., additional, Jowdy, Patrick K., additional, Kalb, Samuel, additional, Keating, Robert F., additional, Kelly, Cory M., additional, Kitchen, Neil D., additional, Ko, Andrew L., additional, Koch, Matthew J., additional, Kondziolka, Douglas, additional, Kuo, Chao-Hung, additional, Larson, A. Noelle, additional, Lawton, Michael T., additional, Lee, Amy, additional, Levitt, Michael R., additional, Levy, Elad I., additional, Loeffler, Jay S., additional, Lucas, Timothy H, additional, Magge, Suresh N., additional, Marchan, Edward M., additional, Marsh, Henry, additional, Mason, Alexander M., additional, Mastorakos, Panagiotis, additional, McCracken, D. Jay, additional, Midha, Rajiv, additional, Morton, Ryan P., additional, Mueller, Kyle, additional, Mullin, Jeffrey P., additional, Nadi, Mustafa, additional, Nakaji, Peter, additional, Nerva, John D., additional, Niazi, Toba N., additional, Ojemann, Jeffrey G., additional, Oyelese, Adetokunbo, additional, Oyesiku, Nelson M., additional, Patel, Anoop P., additional, Peterson, Eric C., additional, Polly, David W., additional, Quach, Helen, additional, Rajan, Shobana, additional, Ravanpay, Ali, additional, Robinson, Leslie C., additional, Rocha, Ricardo, additional, Royce, Trevor J., additional, Rutka, James T., additional, Sekhar, Laligam N., additional, Selman, Warren, additional, Shah, Ashish H., additional, Shallwani, Hussain, additional, Sharma, Deepak, additional, Sharma, Mohan Raj, additional, Silbergeld, Daniel L., additional, Silva, Dulanka, additional, da Silva, Harley Brito, additional, Silveira, Luke, additional, Smith, Edward, additional, Solari, Domenico, additional, Soliman, Hesham, additional, Somma, Teresa, additional, Starke, Robert M., additional, Straus, David C., additional, Teo, Charles, additional, Toma, Ahmed, additional, Tseng, Yolanda D., additional, Tubbs, R. Shane, additional, Vakharia, Kunal, additional, Villa, Alessandro, additional, Wait, Scott D., additional, Walcott, Brian P., additional, Wathen, Connor, additional, Wellons, John C., additional, Wilson, Mark, additional, Wolf, Amparo, additional, Xu, Linda, additional, Yang, Tong, additional, Young, Christopher C., additional, and Zrinzo, Ludvic, additional

Published
2018
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13. Signature morpho-electric properties of diverse GABAergic interneurons in the human neocortex

Author

Lee, Brian, primary, Dalley, Rachel, additional, Miller, Jeremy A, additional, Chartrand, Thomas, additional, Close, Jennie, additional, Mann, Rusty, additional, Mukora, Alice, additional, Ng, Lindsay, additional, Alfiler, Lauren, additional, Baker, Katherine, additional, Bertagnolli, Darren, additional, Brouner, Krissy, additional, Casper, Tamara, additional, Csajbok, Eva, additional, Dee, Nick, additional, Donadio, Nicholas, additional, Driessens, Stan L.W., additional, Egdorf, Tom, additional, Enstrom, Rachel, additional, Galakhova, Anna A, additional, Gary, Amanda, additional, Gelfand, Emily, additional, Goldy, Jeff, additional, Hadley, Kristen, additional, Heistek, Tim S., additional, Hill, Dijon, additional, Johansen, Nelson, additional, Jorstad, Nik, additional, Kim, Lisa, additional, Kocsis, Agnes Katalin, additional, Kruse, Lauren, additional, Kunst, Michael, additional, Leon, Gabriela, additional, Long, Brian, additional, Mallory, Matthew, additional, Maxwell, Michelle, additional, McGraw, Medea, additional, McMillen, Delissa, additional, Melief, Erica J, additional, Molnar, Gabor, additional, Mortrud, Marty T, additional, Newman, Dakota, additional, Nyhus, Julie, additional, Opitz-Araya, Ximena, additional, Pham, Trangthanh, additional, Pom, Alice, additional, Potekhina, Lydia, additional, Rajanbabu, Ram, additional, Ruiz, Augustin, additional, Sunkin, Susan M, additional, Szots, Ildiko, additional, Taskin, Naz, additional, Thyagarajan, Bargavi, additional, Tieu, Michael, additional, Trinh, Jessica, additional, Vargas, Sara, additional, Vumbaco, David, additional, Waleboer, Femke, additional, Weed, Natalie, additional, Williams, Grace, additional, Wilson, Julia, additional, Yao, Shenqin, additional, Zhou, Thomas, additional, Barzo, Pal, additional, Bakken, Trygve, additional, Cobbs, Charles, additional, Ellenbogen, Richard G., additional, Esposito, Luke, additional, Ferreira, Manuel, additional, Gouwens, Nathan W, additional, Grannan, Benjamin, additional, Gwinn, Ryder P., additional, Hauptman, Jason S., additional, Hodge, Rebecca, additional, Jarsky, Tim, additional, Keene, C.Dirk, additional, Ko, Andrew L., additional, Levi, Boaz, additional, Ojemann, Jeffrey G., additional, Patel, Anoop, additional, Ruzevick, Jacob, additional, Silbergeld, Daniel L., additional, Smith, Kim, additional, Waters, Jack, additional, Zeng, Hongkui, additional, Berg, Jim, additional, Goriounova, Natalia A., additional, Kalmbach, Brian, additional, de Kock, Christiaan P.J., additional, Mansvelder, Huib D, additional, Sorensen, Staci A, additional, Tamas, Gabor, additional, Lein, Ed S., additional, and Ting, Jonathan T, additional

Published
2022
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18. Local connectivity and synaptic dynamics in mouse and human neocortex

Author

Campagnola, Luke, primary, Seeman, Stephanie C., additional, Chartrand, Thomas, additional, Kim, Lisa, additional, Hoggarth, Alex, additional, Gamlin, Clare, additional, Ito, Shinya, additional, Trinh, Jessica, additional, Davoudian, Pasha, additional, Radaelli, Cristina, additional, Kim, Mean-Hwan, additional, Hage, Travis, additional, Braun, Thomas, additional, Alfiler, Lauren, additional, Andrade, Julia, additional, Bohn, Phillip, additional, Dalley, Rachel, additional, Henry, Alex, additional, Kebede, Sara, additional, Alice, Mukora, additional, Sandman, David, additional, Williams, Grace, additional, Larsen, Rachael, additional, Teeter, Corinne, additional, Daigle, Tanya L., additional, Berry, Kyla, additional, Dotson, Nadia, additional, Enstrom, Rachel, additional, Gorham, Melissa, additional, Hupp, Madie, additional, Dingman Lee, Samuel, additional, Ngo, Kiet, additional, Nicovich, Philip R., additional, Potekhina, Lydia, additional, Ransford, Shea, additional, Gary, Amanda, additional, Goldy, Jeff, additional, McMillen, Delissa, additional, Pham, Trangthanh, additional, Tieu, Michael, additional, Siverts, La’Akea, additional, Walker, Miranda, additional, Farrell, Colin, additional, Schroedter, Martin, additional, Slaughterbeck, Cliff, additional, Cobb, Charles, additional, Ellenbogen, Richard, additional, Gwinn, Ryder P., additional, Keene, C. Dirk, additional, Ko, Andrew L., additional, Ojemann, Jeffrey G., additional, Silbergeld, Daniel L., additional, Carey, Daniel, additional, Casper, Tamara, additional, Crichton, Kirsten, additional, Clark, Michael, additional, Dee, Nick, additional, Ellingwood, Lauren, additional, Gloe, Jessica, additional, Kroll, Matthew, additional, Sulc, Josef, additional, Tung, Herman, additional, Wadhwani, Katherine, additional, Brouner, Krissy, additional, Egdorf, Tom, additional, Maxwell, Michelle, additional, McGraw, Medea, additional, Pom, Christina Alice, additional, Ruiz, Augustin, additional, Bomben, Jasmine, additional, Feng, David, additional, Hejazinia, Nika, additional, Shi, Shu, additional, Szafer, Aaron, additional, Wakeman, Wayne, additional, Phillips, John, additional, Bernard, Amy, additional, Esposito, Luke, additional, D’Orazi, Florence D., additional, Sunkin, Susan, additional, Smith, Kimberly, additional, Tasic, Bosiljka, additional, Arkhipov, Anton, additional, Sorensen, Staci, additional, Lein, Ed, additional, Koch, Christof, additional, Murphy, Gabe, additional, Zeng, Hongkui, additional, and Jarsky, Tim, additional

Published
2022
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19. Author Correction:Human neocortical expansion involves glutamatergic neuron diversification (Nature, (2021), 598, 7879, (151-158), 10.1038/s41586-021-03813-8)

Author

Berg, Jim, Sorensen, Staci A., Ting, Jonathan T., Miller, Jeremy A., Chartrand, Thomas, Buchin, Anatoly, Bakken, Trygve E., Budzillo, Agata, Dee, Nick, Ding, Song-Lin, Gouwens, Nathan W., Hodge, Rebecca D., Kalmbach, Brian, Lee, Changkyu, Lee, Brian R., Alfiler, Lauren, Baker, Katherine, Barkan, Eliza, Beller, Allison, Berry, Kyla, Bertagnolli, Darren, Bickley, Kris, Bomben, Jasmine, Braun, Thomas, Brouner, Krissy, Casper, Tamara, Chong, Peter, Crichton, Kirsten, Dalley, Rachel, de Frates, Rebecca, Desta, Tsega, Lee, Samuel Dingman, D’Orazi, Florence, Dotson, Nadezhda, Egdorf, Tom, Enstrom, Rachel, Farrell, Colin, Feng, David, Fong, Olivia, Furdan, Szabina, Galakhova, Anna A., Gamlin, Clare, Gary, Amanda, Glandon, Alexandra, Goldy, Jeff, Gorham, Melissa, Goriounova, Natalia A., Gratiy, Sergey, Graybuck, Lucas, Gu, Hong, Hadley, Kristen, Hansen, Nathan, Heistek, Tim S., Henry, Alex M., Heyer, Djai B., Hill, DiJon, Hill, Chris, Hupp, Madie, Jarsky, Tim, Kebede, Sara, Keene, Lisa, Kim, Lisa, Kim, Mean-Hwan, Kroll, Matthew, Latimer, Caitlin, Levi, Boaz P., Link, Katherine E., Mallory, Matthew, Mann, Rusty, Marshall, Desiree, Maxwell, Michelle, McGraw, Medea, McMillen, Delissa, Melief, Erica, Mertens, Eline J., Mezei, Leona, Mihut, Norbert, Mok, Stephanie, Molnar, Gabor, Mukora, Alice, Ng, Lindsay, Ngo, Kiet, Nicovich, Philip R., Nyhus, Julie, Olah, Gaspar, Oldre, Aaron, Omstead, Victoria, Ozsvar, Attila, Park, Daniel, Peng, Hanchuan, Pham, Trangthanh, Pom, Christina A., Potekhina, Lydia, Rajanbabu, Ramkumar, Ransford, Shea, Reid, David, Rimorin, Christine, Ruiz, Augustin, Sandman, David, Sulc, Josef, Sunkin, Susan M., Szafer, Aaron, Szemenyei, Viktor, Thomsen, Elliot R., Tieu, Michael, Torkelson, Amy, Trinh, Jessica, Tung, Herman, Wakeman, Wayne, Waleboer, Femke, Ward, Katelyn, Wilbers, René, Williams, Grace, Yao, Zizhen, Yoon, Jae-Geun, Anastassiou, Costas, Arkhipov, Anton, Barzo, Pal, Bernard, Amy, Cobbs, Charles, de Witt Hamer, Philip C., Ellenbogen, Richard G., Esposito, Luke, Ferreira, Manuel, Gwinn, Ryder P., Hawrylycz, Michael J., Hof, Patrick R., Idema, Sander, Jones, Allan R., Keene, C. Dirk, Ko, Andrew L., Murphy, Gabe J., Ng, Lydia, Ojemann, Jeffrey G., Patel, Anoop P., Phillips, John W., Silbergeld, Daniel L., Smith, Kimberly, Tasic, Bosiljka, Yuste, Rafael, Segev, Idan, de Kock, Christiaan P. J., Mansvelder, Huibert D., Tamas, Gabor, Zeng, Hongkui, Koch, Christof, and Lein, Ed S.

Abstract

In the version of this Article initially published, the Acknowledgements statement contained an error. Originally appearing with thanks for support given in part as follows, “R01EY023173 from The National Eye Institute, U01MH105982 from the National Institute of Mental Health and Eunice Kennedy Shriver National Institute of Child Health and Human Development, and R011EY023173 from The National Institute of Allergy and Infectious Disease,” the last number (R011EY023173) was mistakenly added and is not in fact a grant or one provided by the NIAID. The mention has been removed. The changes have been made to the online version of the Article.

Published
2022

20. Gene therapy enhances chemotherapy tolerance and efficacy in glioblastoma patients

Author

Adair, Jennifer E., Johnston, Sandra K., Mrugala, Maciej M., Beard, Brian C., Guyman, Laura A., Baldock, Anne L., Bridge, Carly A., Hawkins-Daarud, Andrea, Gori, Jennifer L., Born, Donald E., Gonzalez-Cuyar, Luis F., Silbergeld, Daniel L., Rockne, Russell C., Storer, Barry E., Rockhill, Jason K., Swanson, Kristin R., and Kiem, Hans-Peter

Subjects
Temozolomide -- Research -- Dosage and administration, Gene therapy -- Research -- Health aspects, Glioblastoma multiforme -- Research -- Drug therapy -- Development and progression -- Patient outcomes, Stem cells -- Transplantation, Health care industry
Abstract

BACKGROUND. Temozolomide (TMZ) is one of the most potent chemotherapy agents for the treatment of glioblastoma. Unfortunately, almost half of glioblastoma tumors are TMZ resistant due to overexpression of methylguanine methyltransferase ([MGMT.sup.hi]). Coadministration of [O.sup.6]-benzylguanine ([O.sup.6]BG) can restore TMZ sensitivity, but causes off-target myelosuppression. Here, we conducted a prospective clinical trial to test whether gene therapy to confer [O.sup.6]BG resistance in hematopoietic stem cells (HSCs) improves chemotherapy tolerance and outcome. METHODS. We enrolled 7 newly diagnosed glioblastoma patients with [MGMT.sup.hi] tumors. Patients received autologous gene-modified HSCs following single-agent carmustine administration. After hematopoietic recovery, patients underwent [O.sup.6]BG/TMZ chemotherapy in 28-day cycles. Serial blood samples and tumor images were collected throughout the study. Chemotherapy tolerance was determined by the observed myelosuppression and recovery following each cycle. Patient specific biomathematical modeling of tumor growth was performed. Progression-free survival (PFS) and overall survival (OS) were also evaluated. RESULTS. Gene therapy permitted a significant increase in the mean number of tolerated [O.sup.6]BG/TMZ cycles (4.4 cycles per patient, P < 0.05) compared with historical controls without gene therapy (n = 7 patients, 1.7 cycles per patient). One patient tolerated an unprecedented 9 cycles and demonstrated long-term PFS without additional therapy. Overall, we observed a median PFS of 9 (range 3.5-[57.sup.+]) months and OS of 20 (range 13-[57.sup.+]) months. Furthermore, biomathematical modeling revealed markedly delayed tumor growth at lower cumulative TMZ doses in study patients compared with patients that received standard TMZ regimens without [O.sup.6]BG. CONCLUSION. These data support further development of chemoprotective gene therapy in combination with [O.sup.6]BG and TMZ for the treatment of glioblastoma and potentially other tumors with overexpression of MGMT. TRIAL REGISTRATION. Clinicaltrials.gov NCT00669669. FUNDING. R01CA114218, R01AI080326, R01HL098489, P30DK056465, K01DK076973, R01HL074162, R01CA164371, R01NS060752, U54CA143970., Introduction Glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor in adults, is almost uniformly fatal, carrying a 47% chance of survival at one year from diagnosis and [...]

Published
2014
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21. Signature morpho-electric, transcriptomic, and dendritic properties of human layer 5 neocortical pyramidal neurons

Author

Kalmbach, Brian E., primary, Hodge, Rebecca D., additional, Jorstad, Nikolas L., additional, Owen, Scott, additional, de Frates, Rebecca, additional, Yanny, Anna Marie, additional, Dalley, Rachel, additional, Mallory, Matt, additional, Graybuck, Lucas T., additional, Radaelli, Cristina, additional, Keene, C. Dirk, additional, Gwinn, Ryder P., additional, Silbergeld, Daniel L., additional, Cobbs, Charles, additional, Ojemann, Jeffrey G., additional, Ko, Andrew L., additional, Patel, Anoop P., additional, Ellenbogen, Richard G., additional, Bakken, Trygve E., additional, Daigle, Tanya L., additional, Dee, Nick, additional, Lee, Brian R., additional, McGraw, Medea, additional, Nicovich, Philip R., additional, Smith, Kimberly, additional, Sorensen, Staci A., additional, Tasic, Bosiljka, additional, Zeng, Hongkui, additional, Koch, Christof, additional, Lein, Ed S., additional, and Ting, Jonathan T., additional

Published
2021
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24. Local Connectivity and Synaptic Dynamics in Mouse and Human Neocortex

Author

Campagnola, Luke, primary, Seeman, Stephanie C, additional, Chartrand, Thomas, additional, Kim, Lisa, additional, Hoggarth, Alex, additional, Gamlin, Clare, additional, Ito, Shinya, additional, Trinh, Jessica, additional, Davoudian, Pasha, additional, Radaelli, Cristina, additional, Kim, Mean-Hwan, additional, Hage, Travis, additional, Braun, Thomas, additional, Alfiler, Lauren, additional, Andrade, Juia, additional, Bohn, Phillip, additional, Dalley, Rachel, additional, Henry, Alex, additional, Kebede, Sara, additional, Mukora, Alice, additional, Sandman, David, additional, Williams, Grace, additional, Larsen, Rachael, additional, Teeter, Corinne, additional, Daigle, Tanya L., additional, Berry, Kyla, additional, Dotson, Nadia, additional, Enstrom, Rachel, additional, Gorham, Melissa, additional, Hupp, Madie, additional, Lee, Samuel Dingman, additional, Ngo, Kiet, additional, Nicovich, Rusty, additional, Potekhina, Lydia, additional, Ransford, Shea, additional, Gary, Amanda, additional, Goldy, Jeff, additional, McMillen, Delissa, additional, Pham, Trangthanh, additional, Tieu, Michael, additional, Siverts, La’Akea, additional, Walker, Miranda, additional, Farrell, Colin, additional, Schroedter, Martin, additional, Slaughterbeck, Cliff, additional, Cobb, Charles, additional, Ellenbogen, Richard, additional, Gwinn, Ryder P, additional, Keene, C. Dirk, additional, Ko, Andrew L, additional, Ojemann, Jeffrey G, additional, Silbergeld, Daniel L, additional, Carey, Daniel, additional, Casper, Tamara, additional, Crichton, Kirsten, additional, Clark, Michael, additional, Dee, Nick, additional, Ellingwood, Lauren, additional, Gloe, Jessica, additional, Kroll, Matthew, additional, Sulc, Josef, additional, Tung, Herman, additional, Wadhwani, Katherine, additional, Brouner, Krissy, additional, Egdorf, Tom, additional, Maxwell, Michelle, additional, McGraw, Medea, additional, Pom, Christina Alice, additional, Ruiz, Augustin, additional, Bomben, Jasmine, additional, Feng, David, additional, Hejazinia, Nika, additional, Shi, Shu, additional, Szafer, Aaron, additional, Wakeman, Wayne, additional, Phillips, John, additional, Bernard, Amy, additional, Esposito, Luke, additional, D’Orazi, Florence D, additional, Sunkin, Susan, additional, Smith, Kimberly, additional, Tasic, Bosiljka, additional, Arkhipov, Anton, additional, Sorensen, Staci, additional, Lein, Ed, additional, Koch, Christof, additional, Murphy, Gabe, additional, Zeng, Hongkui, additional, and Jarsky, Tim, additional

Published
2021
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25. Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex

Author

Mich, John K., primary, Graybuck, Lucas T., additional, Hess, Erik E., additional, Mahoney, Joseph T., additional, Kojima, Yoshiko, additional, Ding, Yi, additional, Somasundaram, Saroja, additional, Miller, Jeremy A., additional, Kalmbach, Brian E., additional, Radaelli, Cristina, additional, Gore, Bryan B., additional, Weed, Natalie, additional, Omstead, Victoria, additional, Bishaw, Yemeserach, additional, Shapovalova, Nadiya V., additional, Martinez, Refugio A., additional, Fong, Olivia, additional, Yao, Shenqin, additional, Mortrud, Marty, additional, Chong, Peter, additional, Loftus, Luke, additional, Bertagnolli, Darren, additional, Goldy, Jeff, additional, Casper, Tamara, additional, Dee, Nick, additional, Opitz-Araya, Ximena, additional, Cetin, Ali, additional, Smith, Kimberly A., additional, Gwinn, Ryder P., additional, Cobbs, Charles, additional, Ko, Andrew L., additional, Ojemann, Jeffrey G., additional, Keene, C. Dirk, additional, Silbergeld, Daniel L., additional, Sunkin, Susan M., additional, Gradinaru, Viviana, additional, Horwitz, Gregory D., additional, Zeng, Hongkui, additional, Tasic, Bosiljka, additional, Lein, Ed S., additional, Ting, Jonathan T., additional, and Levi, Boaz P., additional

Published
2021
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28. Contributors

Author

Abdulrauf, Saleem I., primary, Acerbi, Francesco, additional, Appelboom, Geoffrey, additional, Armonda, Rocco A., additional, Balériaux, Danielle, additional, Bambakidis, Nicholas C., additional, Batjer, H. Hunt, additional, Bauman, Joel A., additional, Bell, LCDR Randy S., additional, Belverud, Shawn A., additional, Bendok, Bernard R., additional, Benzel, Edward C., additional, Berger, Mitchel S., additional, Bhangoo, Sandeep S., additional, Bingaman, William, additional, Black, Peter, additional, Blondel, Benjamin, additional, Broggi, Giovanni, additional, Broggi, Morgan, additional, Brotchi, Jacques, additional, Browd, Samuel R., additional, Bruneau, Michaël, additional, Cadotte, David W., additional, Cappabianca, Paolo, additional, Carrau, Ricardo L., additional, Cavallo, Luigi Maria, additional, Celix, Juanita M., additional, Cifarelli, Chris, additional, Cirivello, Lt. Michael, additional, Cohen, Alan R., additional, Connolly, E. Sander, additional, Correa-Correa, Victor, additional, Darbar, Aneela, additional, Di Maio, Salvatore, additional, Eddleman, Christopher S., additional, Ellenbogen, Richard G., additional, Eller, Jorge L., additional, Esposito, Felice, additional, Esposito, Isabella, additional, Fallah, Aria, additional, Fehlings, Michael G., additional, Ferreira, Manuel, additional, Filippidis, Aristotelis S., additional, Fink, James R., additional, Tozer Fink, Kathleen R., additional, Flickinger, John C., additional, Garcia, Rabindranath, additional, Geisler, Fred H., additional, Gelfenbeyn, Mikhail, additional, Gerganov, Venelin M., additional, Getch, Christopher C., additional, Ghobrial, George M., additional, Giussani, Carlo, additional, Goel, Atul, additional, Gokaslan, Ziya L., additional, Goodrich, James Tait, additional, Grant, Gerald A., additional, Gunel, Murat, additional, Hankinson, Todd C., additional, Harrop, James S., additional, Hdeib, Alia, additional, Hoffer, Alan, additional, Hopkins, L. Nelson, additional, Houseman, Clifford M., additional, Hughes, Gwyneth, additional, Jimenez, David F., additional, Kalani, M. Yashar S., additional, Kassam, Amin B., additional, Keating, Robert F., additional, Kelly, Daniel, additional, Kemp, Joanna, additional, Khandekar, Melin, additional, Kim, Louis J., additional, Kondziolka, Douglas, additional, Lafage, Virginie, additional, Landriel, Federico, additional, Lapointe, Geneviève, additional, Larson, A. Noelle, additional, Laufer, Ilya, additional, Lebovitz, Jonathon J., additional, Lefranc, Florence, additional, Levitt, Michael R., additional, Levy, Elad I., additional, Liu, James K.C., additional, Loeffler, Jay, additional, Loeser, John, additional, López, Ramón López, additional, Lucas, Timothy H., additional, Lunsford, L. Dade, additional, Macyszyn, Luke J., additional, Madera, Marcella A., additional, Magge, Suresh N., additional, Malik, Ghaus M., additional, Manson, Paul N., additional, Marchan, Edward M., additional, Marras, Carlo, additional, Marsh, Henry, additional, Matula, Christian, additional, McLaughlin, Nancy, additional, Messina, Giuseppe, additional, Mantovani, Alessandra, additional, Morton, Ryan, additional, Muh, Carrie R., additional, Narayan, Raj K., additional, Natarajan, Sabareesh K., additional, Niranjan, Ajay, additional, Ojemann, Jeffrey G., additional, Oluigbo, Chima O., additional, Oyesiku, Nelson M., additional, Ozturk, Ali K., additional, Palejwala, Sheri K., additional, Piazza, Matthew, additional, Polly, David W., additional, Prevedello, Daniel M., additional, Radon, Anja-Maria, additional, Rajan, Govind, additional, Rezai, Ali R., additional, Rodriguez, Eduardo, additional, Rutka, James T., additional, Samii, Madjid, additional, Samuelson, Mical, additional, Sanai, Nader, additional, Sasaki-Adams, Deanna, additional, Savage, Jennifer Gentry, additional, Schlesinger, David, additional, Schwab, Frank, additional, Sciubba, Daniel, additional, Scott, R. Michael, additional, Sekhar, Laligam N., additional, Selman, Warren, additional, Seruya, Mitchel, additional, Sgouros, Spyros, additional, Sheehan, Jason P., additional, Shih, Helen, additional, Siddiqui, Adnan H., additional, Silbergeld, Daniel L., additional, Singer, Justin, additional, Smith, Edward R., additional, Stagno, Vita, additional, Štenˇo, Juraj, additional, Sutton, Leslie N., additional, Sweeney, Justin M., additional, Taghva, Alexander S., additional, Tariq, Farzana, additional, Teo, Charles, additional, Theodore, Nicholas, additional, Tubbs, R. Shane, additional, Two, Aimee, additional, Wait, Scott D., additional, Walter, Grace Elisabeth, additional, Weeks, Adrienne, additional, Wellons, John C., additional, Yang, Lynda J.-S., additional, and Yen, Chun Po, additional

Published
2012
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30. Contributors

Author

Abbott, Rick, primary, Acosta, Frank, additional, Allen, R. Todd, additional, Alvernia, Jorge E., additional, Anand, Vijay K., additional, Angeles, Carmina F., additional, Aryan, Henry E., additional, Awad, Issam, additional, Badie, Behnam, additional, Badlani, Neil, additional, Baird, Lissa C., additional, Batjer, H. Hunt, additional, Belzberg, Allan J., additional, Bendok, Bernard R., additional, Benzel, Edward C., additional, Bettegowda, Chetan, additional, Bingaman, William E., additional, Bookland, Markus, additional, Burchiel, Kim, additional, Bydon, Mohamad, additional, Campbell, Peter G., additional, Chaichana, Kaisorn L., additional, Chaudhary, Saad B., additional, Chen, Mike Yue, additional, Chen, Tsulee, additional, Chou, Dean, additional, Ciacci, Joseph D., additional, Cohen, Steven R., additional, Colby, Geoffrey P., additional, Connolly, E. Sander, additional, Conway, James E., additional, Dacey, Ralph G., additional, Dey, Mahua, additional, Dorsi, Michael J., additional, Duenas, Matthew J., additional, Dunn, Gavin P., additional, Eddleman, Christopher S., additional, Elhammady, Mohamed Samy, additional, Farin, Azadeh, additional, Fessler, Richard G., additional, Francis, Howard W., additional, Frank, Ryan C., additional, Fraser, Justin F., additional, Fukushima, Takanori, additional, Gallia, Gary, additional, Garcia-Aguilar, Julio, additional, Garonzik, Ira M., additional, Hayden Gephart, Melanie G., additional, Germanwala, Anand V., additional, Getch, Christopher C., additional, Giannotta, Steven, additional, Gigante, Paul, additional, Giliberto, Giuliano, additional, Gonda, David, additional, Gonzalez-Martinez, Jorge Alvaro, additional, Gross, Robert E., additional, Harrop, James S., additional, Hebb, Adam O., additional, Hernesniemi, Juha, additional, Heros, Roberto C., additional, Herrera, Sebastian R., additional, Hiremath, Girish K., additional, Ho, Allen, additional, Hughes, Samuel A., additional, Hutton, Daniel S., additional, Isaacs, Robert E., additional, Jaffe, Jennifer, additional, Jallo, George I., additional, Jallo, Jack I., additional, Jandial, Rahul, additional, Jankowski, Pawel, additional, Javalkar, Vijayakumar, additional, Jian, Brian, additional, Johnson, J. Patrick, additional, Johnston, James M., additional, Kaiser, Michael G., additional, Kanter, Adam S., additional, Kellner, Christopher P., additional, Keshavarzi, Sassan, additional, Kim, Bong-Soo, additional, Kim, Kee D., additional, Kretzer, Ryan M., additional, Lanzino, Giuseppe, additional, Lawton, Michael T., additional, Lee, Marco, additional, Lehecka, Martin, additional, Levy, Michael L., additional, Liauw, Jason, additional, Lim, Michael, additional, Link, Timothy, additional, Liu, John C., additional, Lochhead, Richard A., additional, Lokuketagoda, Jaliya R., additional, Lu, Daniel C., additional, Lulic, Dzenan, additional, Madhok, Ricky, additional, Manley, Geoffrey T., additional, Martinez, Joseph L., additional, Matheus, Virgilio, additional, Mbabuike, Nnenna, additional, McDermott, Michael W., additional, Mehta, Vivek, additional, Meltzer, Hal, additional, Menon, Jayant P., additional, Monaco, Edward A., additional, Mummaneni, Praveen V., additional, Mummaneni, Valli P., additional, Nanda, Anil, additional, Niemelä, Mika, additional, Nimjee, Shahid M., additional, Ogilvy, Christopher S., additional, Okonkwo, David O., additional, Olivi, Alessandro, additional, O'Toole, John E., additional, Papanastassiou, Alexander M., additional, Park, Jon, additional, Parsa, Andrew T., additional, Perez-Cruet, Mick, additional, Peterson, Erika Anne, additional, Porter, Randall W., additional, Potts, Mathew B., additional, Quiñones-Hinojosa, Alfredo, additional, Radovanovic, Ivan, additional, Raslan, Ahmed, additional, Raza, Shaan M., additional, Recinos, Pablo F., additional, Reynolds, Matthew R., additional, Rivas, Alejandro, additional, Sanai, Nader, additional, Schulz, Matthias, additional, Schwartz, Theodore H., additional, Scibelli, Stephen S., additional, Silbergeld, Daniel L., additional, Slavin, Konstantin V., additional, Smyth, Matthew D., additional, Sonntag, Volker, additional, Spencer, Dennis D., additional, Steinberg, Gary K., additional, Stiver, Shirley I., additional, Subbaiah, Sathish, additional, Sughrue, Michael E., additional, Sugrue, Patrick A., additional, Syed, Omar N., additional, Tamargo, Rafael J., additional, Teegala, Ramesh, additional, Teo, Charles, additional, Theodore, Nicholas, additional, Thomale, Ulrich W., additional, Thomas, Andrew P., additional, Thompson, B. Gregory, additional, Tobler, William D., additional, Tomycz, Nestor D., additional, Tormenti, Matthew J., additional, Uschold, Timothy D., additional, Vannemreddy, Prasad, additional, Vasudevan, Ram R., additional, Vaynman, Shoshanna, additional, Vives, Kenneth P., additional, Wallace, M. Christopher, additional, Wang, Michael Y., additional, Wang, Vincent Y., additional, Ware, Marcus L., additional, Washington, Chad W., additional, Waters, J. Dawn, additional, Whitworth, Louis Anthony, additional, Woods, Kamal R.M., additional, Woodworth, Graeme F., additional, Zakarevicius, Zilvinas, additional, Zipfel, Gregory J., additional, and Zussman, Benjamin M., additional

Published
2011
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32. Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex

Author

Kim, Mean-Hwan, primary, Radaelli, Cristina, additional, Thomsen, Elliot R., additional, Machen, Deja, additional, Chartrand, Tom, additional, Jorstad, Nikolas L., additional, Mahoney, Joseph T., additional, Taormina, Michael J., additional, Long, Brian, additional, Baker, Katherine, additional, Campagnola, Luke, additional, Casper, Tamara, additional, Clark, Michael, additional, Dee, Nick, additional, D’Orazi, Florence, additional, Gamlin, Clare, additional, Kalmbach, Brian, additional, Kebede, Sara, additional, Lee, Brian R., additional, Ng, Lindsay, additional, Trinh, Jessica, additional, Cobbs, Charles, additional, Gwinn, Ryder P., additional, Keene, C. Dirk, additional, Ko, Andrew L., additional, Ojemann, Jeffrey G., additional, Silbergeld, Daniel L., additional, Sorensen, Staci A., additional, Berg, Jim, additional, Smith, Kimberly, additional, Nicovich, Philip R., additional, Jarsky, Tim, additional, Murphy, Gabe, additional, Zeng, Hongkui, additional, Ting, Jonathan T., additional, Levi, Boaz P., additional, and Lein, Ed S., additional

Published
2020
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33. Human cortical expansion involves diversification and specialization of supragranular intratelencephalic-projecting neurons

Author

Berg, Jim, primary, Sorensen, Staci A., additional, Ting, Jonathan T., additional, Miller, Jeremy A., additional, Chartrand, Thomas, additional, Buchin, Anatoly, additional, Bakken, Trygve E., additional, Budzillo, Agata, additional, Dee, Nick, additional, Ding, Song-Lin, additional, Gouwens, Nathan W., additional, Hodge, Rebecca D., additional, Kalmbach, Brian, additional, Lee, Changkyu, additional, Lee, Brian R., additional, Alfiler, Lauren, additional, Baker, Katherine, additional, Barkan, Eliza, additional, Beller, Allison, additional, Berry, Kyla, additional, Bertagnolli, Darren, additional, Bickley, Kris, additional, Bomben, Jasmine, additional, Braun, Thomas, additional, Brouner, Krissy, additional, Casper, Tamara, additional, Chong, Peter, additional, Crichton, Kirsten, additional, Dalley, Rachel, additional, de Frates, Rebecca, additional, Desta, Tsega, additional, Dingman Lee, Samuel, additional, D’Orazi, Florence, additional, Dotson, Nadezhda, additional, Egdorf, Tom, additional, Enstrom, Rachel, additional, Farrell, Colin, additional, Feng, David, additional, Fong, Olivia, additional, Furdan, Szabina, additional, Galakhova, Anna A., additional, Gamlin, Clare, additional, Gary, Amanda, additional, Glandon, Alexandra, additional, Goldy, Jeff, additional, Gorham, Melissa, additional, Goriounova, Natalia A., additional, Gratiy, Sergey, additional, Graybuck, Lucas, additional, Gu, Hong, additional, Hadley, Kristen, additional, Hansen, Nathan, additional, Heistek, Tim S., additional, Henry, Alex M., additional, Heyer, Djai B., additional, Hill, DiJon, additional, Hill, Chris, additional, Hupp, Madie, additional, Jarsky, Tim, additional, Kebede, Sara, additional, Keene, Lisa, additional, Kim, Lisa, additional, Kim, Mean-Hwan, additional, Kroll, Matthew, additional, Latimer, Caitlin, additional, Levi, Boaz P., additional, Link, Katherine E., additional, Mallory, Matthew, additional, Mann, Rusty, additional, Marshall, Desiree, additional, Maxwell, Michelle, additional, McGraw, Medea, additional, McMillen, Delissa, additional, Melief, Erica, additional, Mertens, Eline J., additional, Mezei, Leona, additional, Mihut, Norbert, additional, Mok, Stephanie, additional, Molnar, Gabor, additional, Mukora, Alice, additional, Ng, Lindsay, additional, Ngo, Kiet, additional, Nicovich, Philip R., additional, Nyhus, Julie, additional, Olah, Gaspar, additional, Oldre, Aaron, additional, Omstead, Victoria, additional, Ozsvar, Attila, additional, Park, Daniel, additional, Peng, Hanchuan, additional, Pham, Trangthanh, additional, Pom, Christina A., additional, Potekhina, Lydia, additional, Rajanbabu, Ramkumar, additional, Ransford, Shea, additional, Reid, David, additional, Rimorin, Christine, additional, Ruiz, Augustin, additional, Sandman, David, additional, Sulc, Josef, additional, Sunkin, Susan M., additional, Szafer, Aaron, additional, Szemenyei, Viktor, additional, Thomsen, Elliot R., additional, Tieu, Michael, additional, Torkelson, Amy, additional, Trinh, Jessica, additional, Tung, Herman, additional, Wakeman, Wayne, additional, Ward, Katelyn, additional, Wilbers, René, additional, Williams, Grace, additional, Yao, Zizhen, additional, Yoon, Jae-Geun, additional, Anastassiou, Costas, additional, Arkhipov, Anton, additional, Barzo, Pal, additional, Bernard, Amy, additional, Cobbs, Charles, additional, de Witt Hamer, Philip C., additional, Ellenbogen, Richard G., additional, Esposito, Luke, additional, Ferreira, Manuel, additional, Gwinn, Ryder P., additional, Hawrylycz, Michael J., additional, Hof, Patrick R., additional, Idema, Sander, additional, Jones, Allan R., additional, Keene, C.Dirk, additional, Ko, Andrew L., additional, Murphy, Gabe J., additional, Ng, Lydia, additional, Ojemann, Jeffrey G., additional, Patel, Anoop P., additional, Phillips, John W., additional, Silbergeld, Daniel L., additional, Smith, Kimberly, additional, Tasic, Bosiljka, additional, Yuste, Rafael, additional, Segev, Idan, additional, de Kock, Christiaan P.J., additional, Mansvelder, Huibert D., additional, Tamas, Gabor, additional, Zeng, Hongkui, additional, Koch, Christof, additional, and Lein, Ed S., additional

Published
2020
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34. Functional Enhancer Elements Drive Subclass-Selective Expression from Mouse to Primate Neocortex

Author

Mich, John K., primary, Graybuck, Lucas T., additional, Hess, Erik, additional, Mahoney, Joseph, additional, Kojima, Yoshiko, additional, Ding, Yi, additional, Somasundaram, Saroja, additional, Miller, Jeremy A., additional, Weed, Natalie, additional, Omstead, Victoria, additional, Bishaw, Yemeserach, additional, Shapovalova, Nadiya, additional, Martinez, Refugio, additional, Fong, Olivia, additional, Yao, Shenqin, additional, Mortrud, Marty, additional, Chong, Peter, additional, Loftus, Luke, additional, Bertagnolli, Darren, additional, Goldy, Jeff, additional, Casper, Tamara, additional, Dee, Nick, additional, Opitz-Araya, Ximena, additional, Cetin, Ali, additional, Smith, Kimberly A., additional, Gwinn, Ryder P., additional, Cobbs, Charles, additional, Ko, Andrew L., additional, Ojemann, Jeffrey G., additional, Keene, C. Dirk, additional, Silbergeld, Daniel L., additional, Sunkin, Susan M., additional, Gradinaru, Viviana, additional, Horwitz, Gregory D., additional, Zeng, Hongkui, additional, Tasic, Bosiljka, additional, Lein, Ed, additional, Ting, Jonathan, additional, and Levi, Boaz, additional

Published
2020
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37. Epigenetic landscape and AAV targeting of human neocortical cell classes

Author

Mich, John K., Hess, Erik E., Graybuck, Lucas T., Somasundaram, Saroja, Miller, Jeremy A., Ding, Yi, Shapovalova, Nadiya V., Fong, Olivia, Yao, Shenqin, Mortrud, Marty, Chong, Peter, Bertagnolli, Darren, Goldy, Jeff, Casper, Tamara, Kroll, Matthew, Hodge, Rebecca D., Bakken, Trygve E., Yao, Zizhen, Dee, Nick, Cetin, Ali, Smith, Kimberly A., Gwinn, Ryder P., Cobbs, Charles, Ko, Andrew. L., Ojemann, Jeffrey G., Keene, C. Dirk, Silbergeld, Daniel. L., Gradinaru, Viviana, Sunkin, Susan M., Zeng, Hongkui, Lein, Ed S., Tasic, Bosiljka, Ting, Jonathan T., and Levi, Boaz P.

Abstract

Myriad cell types comprise the human neocortex, but their roles in normal brain function and disease are largely unknown because few tools exist. To find enhancer elements useful for cell type-specific genetic tools, we examined chromatin accessibility in >2,800 high-quality single human neocortical nuclei. Accessible elements frequently are conserved in mouse (34%), often overlap with hypomethylated sites (27%), and connect cell types with neurological diseases via trait-associated SNPs. Directly testing these elements in viral vectors demonstrates functional enhancer activity with cell type specificity predicted by their chromatin accessibility patterns. In summary we present a catalog of human cell class-specific epigenetic elements, and utilize them for new species-agnostic cell type-specific viral genetic tools, which will illuminate human neuron function and drive gene therapy applications. One sentence summary Mapping chromatin accessibility in human brain cell classes links gene regulation to disease and enables human genetic tools.

Published
2019
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47. h-channels contribute to divergent electrophysiological properties of supragranular pyramidal neurons in human versus mouse cerebral cortex

Author

Kalmbach, Brian E, Buchin, Anatoly, Long, Brian, Close, Jennie, Nandi, Anirban, Miller, Jeremy A, Bakken, Trygve E, Hodge, Rebecca D, Chong, Peter, de Frates, Rebecca, Dai, Kael, Maltzer, Zoe, Nicovich, Philip R, Keene, C Dirk, Silbergeld, Daniel L, Gwinn, Ryder P, Cobbs, Charles, Ko, Andrew L, Ojemann, Jeffrey G, Koch, Christof, Anastassiou, Costas A, Lein, Ed S, and Ting, Jonathan T

Subjects
Adult, Cerebral Cortex, Male, Potassium Channels, Pyramidal Cells, Cell Membrane, Models, Neurological, food and beverages, Mice, Transgenic, Article, Membrane Potentials, Mice, Inbred C57BL, nervous system, Species Specificity, Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels, Animals, Humans, Female
Abstract

Gene expression studies suggest that differential ion channel expression contributes to differences in rodent versus human neuronal physiology. We tested whether h-channels more prominently contribute to the physiological properties of human compared to mouse supragranular pyramidal neurons. Single-cell/nucleus RNA sequencing revealed ubiquitous HCN1-subunit expression in excitatory neurons in human, but not mouse, supragranular layers. Using patch-clamp recordings, we found stronger h-channel-related membrane properties in supragranular pyramidal neurons in human temporal cortex, compared to mouse supragranular pyramidal neurons in temporal association area. The magnitude of these differences depended upon cortical depth and was largest in pyramidal neurons in deep L3. Additionally, pharmacologically blocking h-channels produced a larger change in membrane properties in human compared to mouse neurons. Finally, using biophysical modeling, we provide evidence that h-channels promote the transfer of theta frequencies from dendrite-to-soma in human L3 pyramidal neurons. Thus, h-channels contribute to between-species differences in a fundamental neuronal property.

Published
2018

49. Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex

Author

Mich, John K., primary, Graybuck, Lucas T., additional, Hess, Erik E., additional, Mahoney, Joseph T., additional, Kojima, Yoshiko, additional, Ding, Yi, additional, Somasundaram, Saroja, additional, Miller, Jeremy A., additional, Weed, Natalie, additional, Omstead, Victoria, additional, Bishaw, Yemeserach, additional, Shapovalova, Nadiya V., additional, Martinez, Refugio A., additional, Fong, Olivia, additional, Yao, Shenqin, additional, Mortrud, Marty, additional, Chong, Peter, additional, Loftus, Luke, additional, Bertagnolli, Darren, additional, Goldy, Jeff, additional, Casper, Tamara, additional, Dee, Nick, additional, Opitz-Araya, Ximena, additional, Cetin, Ali, additional, Smith, Kimberly A., additional, Gwinn, Ryder P., additional, Cobbs, Charles, additional, Ko, Andrew. L., additional, Ojemann, Jeffrey G., additional, Keene, C. Dirk, additional, Silbergeld, Daniel. L., additional, Sunkin, Susan M., additional, Gradinaru, Viviana, additional, Horwitz, Gregory D., additional, Zeng, Hongkui, additional, Tasic, Bosiljka, additional, Lein, Ed S., additional, Ting, Jonathan T., additional, and Levi, Boaz P., additional

Published
2019
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