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2. Transcription factors gene expression in chronic rhinosinusitis with and without nasal polyps

Author

Soklic Tanja Kosak, Rijavec Matija, Silar Mira, Koren Ana, Kern Izidor, Hocevar-Boltezar Irena, and Korosec Peter

Subjects
chronic rhinosinusitis, nasal polyps, th1 cells, th2 cells, th17 cells, transcription factors, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Chronic rhinosinusitis (CRS) current therapeutic approaches still fail in some patients with severe persistent symptoms and recurrences after surgery. We aimed to evaluate the master transcription factors gene expression levels of T cell subtypes in chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP) that could represent new, up-stream targets for topical DNAzyme treatment.

Published
2019
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10. The culprit insect but not severity of allergic reactions to bee and wasp venom can be determined by molecular diagnosis

Author

Gattinger, Pia, Lupinek, Christian, Kalogiros, Lampros, Silar, Mira, Zidarn, Mihaela, Korosec, Peter, Koessler, Christine, Novak, Natalija, Valenta, Rudolf, and Mittermann, Irene

Subjects
European People, German People, venom, Wasp Venoms, Toxicology, Pathology and Laboratory Medicine, Severity of Illness Index, alergija in imunologija -- diagnostika, Allergies, Medicine and Health Sciences, Toxins, Ethnicities, reakcije po piku, Bites and Stings, strup, Enzyme-Linked Immunoassays, čebela, Eukaryota, imunoterapija, Bees, allergens -- diagnosis, Insects, Bee Venoms, Molecular Diagnostic Techniques, Medicine, wasp, hymenoptera, immunotherapy, Research Article, Arthropoda, Science, Toxic Agents, Immunology, udc:616-097, macromolecular substances, systemic reactions, Research and Analysis Methods, complex mixtures, alergeni -- diagnostika, allergy and immunology -- diagnosis, sistemske reakcije, Diagnostic Medicine, molecular diagnosis, Hypersensitivity, sting reactions, Animals, Humans, molekularna diagnostika, Immunoassays, Skin Tests, Venoms, fungi, Organisms, Biology and Life Sciences, Allergens, Immunoglobulin E, Invertebrates, Hymenoptera, osa, Slovenian People, People and Places, Immunologic Techniques, Clinical Immunology, Population Groupings, Immunization, kožekrilci, Clinical Medicine, bee, Slavic People
Abstract

BackgroundAllergy to bee and wasp venom can lead to life-threatening systemic reactions. The identification of the culprit species is important for allergen-specific immunotherapy.ObjectivesTo determine a panel of recombinant bee and wasp allergens which is suitable for the identification of bee or wasp as culprit allergen sources and to search for molecular surrogates of clinical severity of sting reactions.MethodsSera from eighty-seven patients with a detailed documentation of their severity of sting reaction (Mueller grade) and who had been subjected to titrated skin testing with bee and wasp venom were analyzed for bee and wasp-specific IgE levels by ImmunoCAPTM. IgE-reactivity testing was performed using a comprehensive panel of recombinant bee and wasp venom allergens (rApi m 1, 2, 3, 4, 5 and 10; rVes v 1 and 5) by ISAC chip technology, ImmunoCAP and ELISA. IgG4 antibodies to rApi m 1 and rVes v 5 were determined by ELISA and IgE/IgG4 ratios were calculated. Results from skin testing, IgE serology and IgE/IgG4 ratios were compared with severity of sting reactions.ResultsThe panel of rApi m 1, rApi m 10, rVes v 1 and rVes v 5 allowed identification of the culprit venom in all but two of the 87 patients with good agreement to skin testing. Severities of sting reactions were not associated with results obtained by skin testing, venom-specific IgE levels or molecular diagnosis. Severe sting reactions were observed in patients showing < 1 ISU and < 2kUA/L of IgE to Api m 1 and/or Ves v 5.ConclusionWe identified a minimal panel of recombinant bee and wasp allergens for molecular diagnosis which may permit identification of bee and/or wasp as culprit insect in venom-sensitized subjects. The severity of sting reactions was not associated with parameters obtained by molecular diagnosis.

Published
2020

14. Mast cell activation test in the diagnosis of allergic disease and anaphylaxis

Author

Bahri, Rajia, Custovic, Adnan, Korosec, Peter, Tsoumani, Marina, Barron, Martin, Wu, Jiakai, Sayers, Rebekah, Weimann, Alf, Ruiz-Garcia, Monica, Patel, Nandinee, Robb, Abigail, Shamji, M. H., Fontanella, Sara, Silar, Mira, Mills, ENC, Simpson, Angela, Turner, Paul J, Bulfone-Paus, Silvia, Medical Research Council (MRC), Imperial College Healthcare NHS Trust- BRC Funding, National Institute for Health Research, and Commission of the European Communities

Subjects
MC, Mast cell, hMC, Human blood-derived mast cell, Allergy, diagnosis, FDA, Functional data analysis, Immunology, DEGRANULATION, PBST, PBS containing 0.1% Tween 20, ROC, Receiver operating characteristic, ICC, Intraclass correlation, mast cells, CHILDREN, PEANUT, Article, CULTURE, Manchester Institute of Biotechnology, IGE-SENSITIZATION, TOLERANCE, Anaphylaxis, METAANALYSIS, food allergy, Science & Technology, sIgE, Allergen-specific IgE, peanut allergy, SPT, Skin prick test, mast cell activation test, ResearchInstitutes_Networks_Beacons/manchester_institute_of_biotechnology, AUC, Area under the curve, PGD2, Prostaglandin D2, CRTH2, Chemoattractant receptor–homologous molecule expressed of TH2 cells, PREVALENCE, CD-sens, Threshold sensitivity, BASOPHIL ACTIVATION, basophil activation test, 1107 Immunology, BAT, Basophil activation test, FPC, Functional principal component, MAT, Mast cell activation test, DBPCFC, Double-blind, placebo-controlled food challenge, Life Sciences & Biomedicine
Abstract

Background Food allergy is an increasing public health issue and the most common cause of life-threatening anaphylactic reactions. Conventional allergy tests assess for the presence of allergen-specific IgE, significantly overestimating the rate of true clinical allergy and resulting in overdiagnosis and adverse effect on health-related quality of life. Objective To undertake initial validation and assessment of a novel diagnostic tool, we used the mast cell activation test (MAT). Methods Primary human blood-derived mast cells (MCs) were generated from peripheral blood precursors, sensitized with patients' sera, and then incubated with allergen. MC degranulation was assessed by means of flow cytometry and mediator release. We compared the diagnostic performance of MATs with that of existing diagnostic tools to assess in a cohort of peanut-sensitized subjects undergoing double-blind, placebo-controlled challenge. Results Human blood-derived MCs sensitized with sera from patients with peanut, grass pollen, and Hymenoptera (wasp venom) allergy demonstrated allergen-specific and dose-dependent degranulation, as determined based on both expression of surface activation markers (CD63 and CD107a) and functional assays (prostaglandin D2 and β-hexosaminidase release). In this cohort of peanut-sensitized subjects, the MAT was found to have superior discrimination performance compared with other testing modalities, including component-resolved diagnostics and basophil activation tests. Using functional principle component analysis, we identified 5 clusters or patterns of reactivity in the resulting dose-response curves, which at preliminary analysis corresponded to the reaction phenotypes seen at challenge. Conclusion The MAT is a robust tool that can confer superior diagnostic performance compared with existing allergy diagnostics and might be useful to explore differences in effector cell function between basophils and MCs during allergic reactions., Graphical abstract

Published
2018

15. Mast cell activation test in the diagnosis of allergic disease and anaphylaxis

Author

Bahri, Rajia, primary, Custovic, Adnan, additional, Korosec, Peter, additional, Tsoumani, Marina, additional, Barron, Martin, additional, Wu, Jiakai, additional, Sayers, Rebekah, additional, Weimann, Alf, additional, Ruiz-Garcia, Monica, additional, Patel, Nandinee, additional, Robb, Abigail, additional, Shamji, Mohamed H., additional, Fontanella, Sara, additional, Silar, Mira, additional, Mills, E.N.Clare, additional, Simpson, Angela, additional, Turner, Paul J., additional, and Bulfone-Paus, Silvia, additional

Published
2018
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17. 7th drug hypersensitivity meeting: part one

Author

Carr, Daniel F., Chung, Wen-Hung, Jenkiins, Rosalind E., Chaponda, Mas, Nwikue, Gospel, Cornejo Castro, Elena M., Antoine, Daniel J., Pirmohamed, Munir, Wuillemin, Natascha, Dina, Dolores, Eriksson, Klara K., Yerly, Daniel, Pavlos, Rebecca, Mckinnin, Elizabeth, Ostrov, David, Peters, Bjoern, Buus, Soren, Koelle, David, Chopra, Abha, Rive, Craig, Redwood, Alec, Restrepo, Susana, Bracey, Austin, Yuan, Jing, Gaudieri, Silvana, Carrington, Mary, Haas, David, Mallal, Simon, Phillips, Elizabeth, De Boer, Douwe, Menheere, Paul, Nieuwhof, Chris, Bons, Judith, Jonsson, Friederike, De Chaisemartin, Luc, Granger, Vanessa, Gillis, Caitlin, Gouel, Aurelie, Neukirch, Catherine, Dib, Fadia, Nicaise, Pascale Roland, Longrois, Dan, Tubach, Florence, Martin, Sylvie, Bruhns, Pierre, Chen, Kai-Lung, Liao, Shu-Ling, Sheen, Yi-Shuan, Cho, Yung-Tsu, Yang, Che-Wen, Liau, Jau-Yu, Chu, Chia-Yu, Aguiar, Rita, Lopes, Anabela, Fernandes, Natália, Viegas, Leonor, Pereira-Barbosa, M. A., Bünter, Antonia, Gupta, Nisha, Petkovic, Tatjana Pecaric, Wirth, Nicole, Pichler, Werner J., Hausmann, Oliver, Yazicioglu, Mehtap, Ozdemir, Pinar G., Ciplak, Gokce, Kaya, Ozkan, Cooke, Peter John, Mota, Inês, Gaspar, Ângela, Benito-Garcia, Filipe, Chambel, Marta, Morais-Almeida, Mário, Marques, Luis, Alcoceba, Eva, Lara, Silvia, Carneiro-Leão, Leonor, Botelho, Carmen, Dias-Castro, Eunice, Cernadas, Josefina R., Nicholls, Katherine, Lay, William, Smith, Olivia, Collins, Christine, Unglik, Gary, Spriggs, Kymble, Auyeung, Priscilla, McComish, Jeremy, Douglass, Jo A., Peter, Jonny G., Potter, Paul, Carolino, Fabrícia, De Castro, Eunice Dias, Moreira, Ana Sofia, Abreu, Carmo, Gomes, Eva, Cardoso, Bárbara Kong, Tomaz, Elza, Correia, Sara, Inácio, Filipe, Arnold, Annabelle, Bear, Natasha, Rueter, Kristina, Gong, Grace, O’Sullivan, Michael, Muthusamy, Saravanan, Noble, Valerie, Lucas, Michaela, Buterleviciute, Neringa, Rudzeviciene, Odilija, May, Sara, Pongdee, Thanai, Park, Miguel, Griguola, Linas, Vinikovas, Arturas, Kašinskaite, Simona, Kvedariene, Violeta, Aktas, Ayse, Rahman, Suheyla, Elbi, Huseyin, Ozyurt, Beyhan Cengiz, Cavkaytar, Ozlem, Karaatmaca, Betul, Cetinkaya, Pinar Gur, Esenboga, Saliha, Sahiner, Umit M., Sekerel, Bulent E., Soyer, Ozge, Zubrinich, Celia, Tong, Bianca, Patel, Mittal, Giles, Michelle, O’Hehir, Robyn, Puy, Robert, Amaral, Luís, Demir, Semra, Gelincik, Asli, Olgac, Muge, Caskun, Raif, Unal, Derya, Colakoglu, Bahauddin, Buyukozturk, Suna, Matute, Olga Vega, Bernad, Amalia, Gastaminza, Gabriel, Madamba, Roselle, Lacasa, Carlos, Goikoetxea, M. J., D’Amelio, Carmen, Rifón, Jose, Martínez, Nicolas, Ferrer, Marta, Ribeiro, Carmelita, Faria, Emília, Frutuoso, Cristina, Barros, Anabela, Lebre, Rosário, Pego, Alice, Bom, Ana Todo, Ensina, Luis Felipe, Aranda, Carolina, Nunes, Ines Camelo, Martins, Ana Maria, Solé, Dirceu, Bavbek, Sevim, Kendirlinan, Resat, Çerçi, Pamir, Tutluer, Seda, Soyyigit, Sadan, Sözener, Zeynep Çelebi, Aydin, Ömür, Gümüsburun, Reyhan, Almeida, Marta, Sai, Kimie, Imatoh, Takuya, Nakamura, Ryosuke, Fukazawa, Chisato, Hinomura, Yasushi, Saito, Yoshiro, Sousa-Pinto, Bernardo, Correia, Cláudia, Gomes, Lídia, Gil-Mata, Sara, Araújo, Luís, Delgado, Luís, Okamoto-Uchida, Yoshimi, Kajinami, Koji, Matsunaga, Kayoko, Aihara, Michiko, Wang, Chuang-Wei, Su, Shih-Chi, Hung, Shuen-Iu, Ho, Hsin-Chun, Yang, Chih-Hsun, Paulmann, Maren, Dunant, Ariane, Mockenhaupt, Maja, Sekula, Peggy, Schumacher, Martin, Kardaun, Sylvia, Naldi, Luigi, Bellón, Teresa, Creamer, Daniel, Haddad, Cynthia, Sassolas, Bruno, Lebrun-Vignes, Bénédicte, Valeyrie-Allanore, Laurence, Roujeau, Jean-Claude, Kremmler, Carmen, Dodiuk-Gad, Roni P., Olteanu, Cristina, Feinstein, Anthony, Hashimoto, Rena, Alhusayen, Raed, Whyte-Croasdaile, Sonia, Finkelstein, Yaron, Burnett, Marjorie, Sade, Shachar, Cartotto, Robert, Jeschke, Marc, Shear, Neil H., Takamura, Naoko, Yamane, Yumiko, Matsukura, Setsuko, Nakamura, Kazuko, Watanabe, Yuko, Yamaguchi, Yukie, Kambara, Takeshi, Ikezawa, Zenro, Chew, Hall, Knezevic, Brittany, Ionmhain, Una Nic, Barraclough, Allison, Anstey, Matthew, Usui, Toru, Meng, Xiaoli, Farrell, John, Whitaker, Paul, Watson, John, French, Neil, Park, Kevin, Naisbitt, Dean, Neves, Ana Castro, Cadinha, Susana, Moreira, Ana, Da Silva, J. P. Moreira, Drvar, Daniela Ledic, Gulin, Sandra Jerkovic, Hadzavdic, Suzana Ljubojevic, Ceovic, Romana, De Francisco, Ana Montoro, De Vicente Jiménez, Talía, Luque, Amelia García, David, Natalia Rosado, Galván, José Mª Mateos, Darlenski, Razvigor, Gulin, Dario, Sikic, Jozica, Habek, Jasna Cerkez, Galic, Edvard, Specht, Philip, Staab, Doris, Mayer, Beate, Roehmel, Jobst, Solovan, Caius, Chiriac, Anca, Djurinec, Paola, Kostovic, Kresimir, Bradamante, Mirna, Almeida, Jose Pedro, Caiado, Joana, Pedro, Elisa, Da Silva, Pedro Canas, Barbosa, Manuel Pereira, Bogas, Gador, Blanca-López, Natalia, Pérez-Alzate, Diana, Doña, Inmaculada, Agúndez, José Augusto, García-Martín, Elena, Cornejo-García, José Antonio, Mayorga, Cristobalina, Torres, María José, Canto, Maria Gabriela, Blanca, Miguel, Aksakal, Sengül, Sin, Aytül Zerrin, Koç, Zeynep Peker, Günsen, Fatma Düsünür, Ardeniz, Ömür, Gökmen, Emine Nihal Mete, Gülbahar, Okan, Kokuludag, Ali, Pérez-Sánchez, Natalia, Salas, María, Salas, Maria, Gomez, Francisca, Barrionuevo, Esther, Andreu, Inmaculada, Miranda, Miguel Ángel, Didžiokaite, Gabija, Gaidej, Olesia, Garcimartin, Maria Isabel, Somoza, Maria Luisa, Bojas, Gador, Cornejo-Garcia, Jose Antonio, Perez, Francisco Javier Ruano, Miranda, Miguel Angel, Jerschow, Elina, Pelletier, Teresa, Ren, Zhen, Hudes, Golda, Sanak, Marek, Morales, Esperanza, Schuster, Victor, Spivack, Simon D, Rosenstreich, David, Erzen, Renato, Silar, Mira, Bajrovic, Nissera, Rijavec, Matija, Zidarn, Mihaela, Korosec, Peter, Castro, Eunice, Al-Ahmad, Mona, Rodriguez, Tito, Azevedo, João Pedro, Tavares, Beatriz, Regateiro, Frederico, Todo-Bom, Ana, Miranda, Pablo Andrés, De La Cruz Hoyos, Bautista, Abuzeid, Waleed, Akbar, Nadeem, Gibber, Marc, Fried, Marvin, Han, Weiguo, Keskin, Taha, Tamayev, Robert, Spivack, Simon D., Boni, Elisa, Russello, Marina, Mauro, Marina, Neto, Marta Ferreira, Brosseron, Lise, Malheiro, Daniela, Barreira, Patrícia, Sprigg, Dustin, Trevenen, Michelle, Seet, Jason, Trubiano, Jason, Smith, William, Jeelall, Yogesh, Vale, Sandra, Loh, Richard, Mclean-Tooke, Andrew, Müller, Sabine, Amstutz, Ursula, Jörg, Lukas, Yawalkar, Nikhil, Krähenbühl, Stephan, Leblanc, Ana, Ribeiro, Laura, Vega, Arantza, Rivas, Raquel Gutierrez, Alonso, Ana, Beitia, Juan Maria, Mateo, Belén, Cárdenas, Remedios, Garcia-Dominguez, Juan Jesus, Strautins, Kaija, James, Ian, Neves, Ana, Do Céu Machado, Maria, Dalgiç, Ceyda Tunakan, Bulut, Gökten, Ardeniz, Fatma Ömür, Hsu, Shao-Hsuan, Ye, Young-Min, Hur, Gyu-Young, Park, Hae-Sim, Kim, Seung-Hyun, Ali, Syed, Hollingsworth, Peter N., Mclean-Tooke, Andrew P. C., Chadly, Zohra, Fredj, Nadia Ben, Aouam, Karim, Romdhane, Haifa Ben, Boughattas, Naceur A., Chaabane, Amel, Salazar, Marina Lluncor, Pola, Beatriz, Fiandor, Ana, Ramírez, Elena, Ortega, Javier Domínguez, Quirce, Santiago, Cabañas, Rosario, Baynova, Krasimira, Labella, Marina, Prados, Manuel, Ramonaite, Agne, Bajoriuniene, Ieva, Sitkauskiene, Brigita, Sakalauskas, Raimundas, Kwon, Jae-Woo, Park, Shinyoung, Silva, Diana, Leão, Leonor Carneiro, Garcimartin, Maria, De La Torre, Maria Vazquez, Pérez, Francisco Javier Ruano, Haroun, Elisa, Diez, Gabriela Canto, Ónodi-Nagy, Katinka, Kinyó, Ágnes, Kemény, Lajos, Bata-Csörgo, Zsuzsanna, Pita, Joana Sofia, Fernandes, Rosa Anita, Moura, Ana, Sousa, Nuno, Loureiro, Carlos, Pfützner, Wolfgang, Marrouche, Nadine, Grattan, Clive, Chen, Yu-En, Chen, Chun-Bing, Hsiao, Yu-Ping, and Ruano, Francisco Javier

Subjects
Pulmonary and Respiratory Medicine, Drug, Allergy, business.industry, media_common.quotation_subject, Immunology, medicine.disease, Meeting Abstracts, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Drug Hypersensitivity Syndrome, 030220 oncology & carcinogenesis, Immunology and Allergy, Medicine, business, media_common
Abstract

Table of contents Oral Abstracts O1 Functionally distinct HMGB1 isoforms correlate with physiological processes in drug-induced SJS/TEN Daniel F. Carr, Wen-Hung Chung, Rosalind E. Jenkiins, Mas Chaponda, Gospel Nwikue, Elena M. Cornejo Castro, Daniel J. Antoine, Munir Pirmohamed O2 Hypersensitivity reactions to beta-lactams, does the t cell recognition pattern influence the clinical picture? Natascha Wuillemin, Dolores Dina, Klara K. Eriksson, Daniel Yerly O3 Specific binding characteristics of HLA alleles associated with nevirapine hypersensitivity Rebecca Pavlos, Elizabeth Mckinnin, David Ostrov, Bjoern Peters, Soren Buus, David Koelle, Abha Chopra, Craig Rive, Alec Redwood, Susana Restrepo, Austin Bracey, Jing Yuan, Silvana Gaudieri, Mary Carrington, David Haas, Simon Mallal, Elizabeth Phillips O4 Do we need to measure total ige for the interpretation of analytical results of ImmunoCAP dnd 3gAllergy specific IgE? Douwe De Boer, Paul Menheere, Chris Nieuwhof, Judith Bons O5 Neutrophil activation in systemic anaphylaxis: results from the multicentric NASA study Friederike Jonsson, Luc De Chaisemartin, Vanessa Granger, Caitlin Gillis, Aurelie Gouel, Catherine Neukirch, Fadia Dib, Pascale Roland Nicaise, Dan Longrois, Florence Tubach, Sylvie Martin, Pierre Bruhns, NASA Study Group O6 Purpuric drug eruptions due to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) for non-small-cell lung cancer (NSCLC): a clinic-pathological study of 32 cases Kai-Lung Chen, Shu-Ling Liao, Yi-Shuan Sheen, Yung-Tsu Cho, Che-Wen Yang, Jau-Yu Liau, Chia-Yu Chu Poster presentations: Poster Walk 1—Anaphylaxis (P01–P09) P1 Anaphylactic reactions during anaesthesia and the perioperative period Rita Aguiar, Anabela Lopes, Natália Fernandes, Leonor Viegas, M. A. Pereira-Barbosa P2 Anaphylaxis to chlorhexidine: is there a cross-reactivity to alexidine? Antonia Bünter, Nisha Gupta, Tatjana Pecaric Petkovic, Nicole Wirth, Werner J. Pichler, Oliver Hausmann P3 Cefotaxime-induced severe anaphylaxis in a neonate Mehtap Yazicioglu, Pinar G. Ozdemir, Gokce Ciplak, Ozkan Kaya P4 Clinical features and diagnosis of anaphylaxis resulting from exposure to chlorhexidine Peter John Cooke P5 Drug-induced anaphylaxis: five-year single-center survey Inês Mota, Ângela Gaspar, Filipe Benito-Garcia, Marta Chambel, Mário Morais-Almeida P6 Intraoperative severe anaphylactic reaction due to patent blue v dye Luis Marques, Eva Alcoceba, Silvia Lara P7 Kounis syndrome in the setting of anaphylaxis to diclofenac Leonor Carneiro-Leão, Carmen Botelho, Eunice Dias-Castro, Josefina Cernadas P8 Perioperative anaphylaxis audit: Royal Melbourne Hospital Katherine Nicholls, William Lay, Olivia Smith, Christine Collins, Gary Unglik, Kymble Spriggs, Priscilla Auyeung, Jeremy McComish, Jo A. Douglass P9 Recurrent peri-operative anaphylaxis: a perfect storm Jonny G. Peter, Paul Potter Poster Walk 2: DH regions and patient groups (P10–P19) P10 A rare presentation of amoxicillin allergy in a young child Fabrícia Carolino, Eunice Dias De Castro, Josefina R. Cernadas P11 Adverse drug reactions in children: antibiotics or virus? Ana Sofia Moreira, Carmo Abreu, Eva Gomes P12 Allergic reactions in invasive medical procedures Bárbara Kong Cardoso, Elza Tomaz, Sara Correia, Filipe Inácio P13 Antibiotic allergy in children: room for improvement Annabelle Arnold, Natasha Bear, Kristina Rueter, Grace Gong, Michael O’Sullivan, Saravanan Muthusamy, Valerie Noble, Michaela Lucas P14 Drug hypersensitivity reactions in children and results of diagnostic evaluation Neringa Buterleviciute, Odilija Rudzeviciene P15 Nonimmediate cutaneous drug reactions in children: are skin tests required? Ana Sofia Moreira, Carmo Abreu, Eva Gomes P16 Pediatric patients with a history of penicillin allergy and a positive penicillin skin test may not be at an increased risk for multiple drug allergies Sara May, Thanai Pongdee, Miguel Park P17 Proved hypersensitivity to drugs according data of Vilnius University Hospital Santariskiu Klinikos Linas Griguola, Arturas Vinikovas, Simona Kašinskaite, Violeta Kvedariene P18 Self-reported prevalence of drug hypersensitivity reactions among students in Celal Bayar University, Turkey Ayse Aktas, Suheyla Rahman, Huseyin Elbi, Beyhan Cengiz Ozyurt P19 Severe drug hypersensitivity reactions in pediatric age Ozlem Cavkaytar, Betul Karaatmaca, Pinar Gur Cetinkaya, Saliha Esenboga, Umit M. Sahiner, Bulent E. Sekerel, Ozge Soyer Poster Walk 3: Desensitisation (P20–P28) P20 A protocol for desensitisation to valaciclovir Celia Zubrinich, Bianca Tong, Mittal Patel, Michelle Giles, Robyn O’Hehir, Robert Puy P21 A rare case of desensitization to modafinil Josefina Cernadas, Luís Amaral, Fabrícia Carolino P22 A sixteen-day desensitization protocol in delayed type hypersensitivity reactions to oral drugs Semra Demir, Asli Gelincik, Muge Olgac, Raif Caskun, Derya Unal, Bahauddin Colakoglu, Suna Buyukozturk P23 Desensitization to intravenous etoposide using a 12 and a 13-step protocol. Two cases report Olga Vega Matute, Amalia Bernad, Gabriel Gastaminza, Roselle Madamba, Carlos Lacasa, M. J. Goikoetxea, Carmen D’Amelio, Jose Rifón, Nicolas Martínez, Marta Ferrer P24 Drug desensitisation in oncology: the experience of an immunoallergology department for 5 years Carmelita Ribeiro, Emília Faria, Cristina Frutuoso, Anabela Barros, Rosário Lebre, Alice Pego, Ana Todo Bom P25 Filgrastim anaphylaxis: a successful desensitization protocol Luis Amaral, Josefina Cernadas P26 Galsulfase hypersensitivity and desensitization of a mucopolysaccharidosis VI patient Luis Felipe Ensina, Carolina Aranda, Ines Camelo Nunes, Ana Maria Martins, Dirceu Solé P27 Rapid drug desensitization with biologicals: one-center experience with four biologicals Sevim Bavbek, Resat Kendirlinan, Pamir Çerçi, Seda Tutluer, Sadan Soyyigit, Zeynep Çelebi Sözener, Ömür Aydin, Reyhan Gümüsburun P28 Successful desensitization to a high dose of methotrexate in a delayed type hypersensitivity reaction Josefina Cernadas, Leonor Carneiro-Leão, Fabrícia Carolino, Marta Almeida Poster Walk 4: SJS (P29–P38) P29 Assessment of impact of infection on drug-induced severe cutaneous adverse reactions and rhabdomyolysis using the Japanese adverse drug event report database Kimie Sai, Takuya Imatoh, Ryosuke Nakamura, Chisato Fukazawa, Yasushi Hinomura, Yoshiro Saito P30 Characterization of erythema multiforme and severe cutaneous adverse reactions hospitalizations Bernardo Sousa-Pinto, Cláudia Correia, Lídia Gomes, Sara Gil-Mata, Luís Araújo, Luís Delgado P31 Effects of infection on incidence/severity of SJS/TEN and myopathy in Japanese cases analyzed by voluntary case reports Ryosuke Nakamura, Kimie Sai, Takuya Imatoh, Yoshimi Okamoto-Uchida, Koji Kajinami, Kayoko Matsunaga, Michiko Aihara, Yoshiro Saito P32 Efficacy of tumor necrosis factor—a antagonists in Stevens–Johnson syndrome and toxic epidermal necrolysis: a randomized controlled trial and immunosuppressive effects evaluation Chuang-Wei Wang, Shih-Chi Su, Shuen-Iu Hung, Hsin-Chun Ho, Chih-Hsun Yang, Wen-Hung Chung P33 Evolution of drug causality in Stevens–Johnson syndrome and toxic epidermal necrolysis in Europe: analysis of 10 years RegiSCAR-Study Maren Paulmann, Ariane Dunant, Maja Mockenhaupt, Peggy Sekula, Martin Schumacher, Sylvia Kardaun, Luigi Naldi, Teresa Bellón, Daniel Creamer, Cynthia Haddad, Bruno Sassolas, Bénédicte Lebrun-Vignes, Laurence Valeyrie-Allanore, Jean-Claude Roujeau P34 Long-term sequelae in patients with Stevens–Johnson syndrome and toxic epidermal necrolysis: a 5-year analysis Maren Paulmann, Carmen Kremmler, Peggy Sekula, Laurence Valeyrie-Allanore, Luigi Naldi, Sylvia Kardaun, Maja Mockenhaupt P35 Major emotional complications and decreased health related quality of life among survivors of Stevens–Johnson syndrome and toxic epidermal necrolysis Roni P. Dodiuk-Gad, Cristina Olteanu, Anthony Feinstein, Rena Hashimoto, Raed Alhusayen, Sonia Whyte-Croasdaile, Yaron Finkelstein, Marjorie Burnett, Shachar Sade, Robert Cartotto, Marc Jeschke, Neil H. Shear P36 Retrospective analysis of Stevens–Johnson syndrome and toxic epidermal necrolysis in Japanese patients: treatment and outcome Naoko Takamura, Yumiko Yamane, Setsuko Matsukura, Kazuko Nakamura, Yuko Watanabe, Yukie Yamaguchi, Takeshi Kambara, Zenro Ikezawa, Michiko Aihara P37 Severe physical complications among survivors of Stevens–Johnson syndrome and toxic epidermal necrolysis Roni P. Dodiuk-Gad, Cristina Olteanu, Rena Hashimoto, Hall Chew, Raed Alhusayen, Sonia Whyte-Croasdaile, Yaron Finkelstein, Marjorie Burnett, Shachar Sade, Robert Cartotto, Marc Jeschke, Neil H. Shear P38 Stevens–Johnson syndrome/toxic epidermal necrolysis combined with haemophagocytic lymphohistiocytosis: a case report Brittany Knezevic, Una Nic Ionmhain, Allison Barraclough, Michaela Lucas, Matthew Anstey Poster Walk 5: Other organs/unexpected immune reactions (P39–P47) P39 A case report of patient with anti-tuberculosis drug-related severe liver failure Toru Usui, Xiaoli Meng, John Farrell, Paul Whitaker, John Watson, Neil French, Kevin Park, Dean Naisbitt P40 Acute interstitial nephritis induced by ibuprofen Ana Castro Neves, Susana Cadinha, Ana Moreira, J. P. Moreira Da Silva P41 Cetuximab induced acneiform rash—two case reports Daniela Ledic Drvar, Sandra Jerkovic Gulin, Suzana Ljubojevic Hadzavdic, Romana Ceovic P42 Enteropathy associated with losartan Ana Montoro De Francisco, Talía De Vicente Jiménez, Amelia García Luque, Natalia Rosado David, José Mª Mateos Galván P43 Granuloma annulare after therapy with canakinumab Razvigor Darlenski P44 Hypersensitivity eosinophilic myocarditis or acute coronary syndrome? Case report Dario Gulin, Jozica Sikic, Jasna Cerkez Habek, Sandra Jerkovic Gulin, Edvard Galic P45 Piperacillin-induced immune haemolytic anaemia: a severe and frequent complication of antibiotic treatment in patients with cystic fibrosis Philip Specht, Doris Staab, Beate Mayer, Jobst Roehmel P46 Progesterone triggered pemphigus foliaceus: case report Sandra Jerkovic Gulin, Caius Solovan, Anca Chiriac P47 Ramipril: triggered generalized pustular psoriasis Paola Djurinec, Kresimir Kostovic, Mirna Bradamante, Sandra Jerkovic Gulin, Romana Ceovic Poster Walk 6: NSAIDs (P48–P56) P48 Aspirin desensitization in cardiovascular disease—Portuguese experience Jose Pedro Almeida, Joana Caiado, Elisa Pedro, Pedro Canas Da Silva, Manuel Pereira Barbosa P49 Asthma and/or rhinitis to NSAIDs with good tolerance to ASA Gador Bogas, Natalia Blanca-López, Diana Pérez-Alzate, Inmaculada Doña, José Augusto Agúndez, Elena García-Martín, José Antonio Cornejo-García, Cristobalina Mayorga, María José Torres, Gabriela Canto, Miguel Blanca P50 Clinical characteristics of 196 patients with non-steroidal anti-inflammatory drug (NSAIDs) hypersensitivity Sengül Aksakal, Aytül Zerrin Sin, Zeynep Peker Koç, Fatma Düsünür Günsen, Ömür Ardeniz, Emine Nihal Mete Gökmen, Okan Gülbahar, Ali Kokuludag P51 Development of immediate hypersensitivity to several NSAIDs maintaining good tolerance to ASA Natalia Pérez-Sánchez, Natalia Blanca-López, Diana Pérez-Alzate, Gador Bogas, Inmaculada Doña, María Salas, María José Torres, Miguel Blanca, Gabriela Canto P52 Diagnosis of hypersensitivity reactions to paracetamol in a large series of cases Inmaculada Doña, Maria Salas, Francisca Gomez, Natalia Blanca-Lopez, Diana Perez-Alzate, Gador Bogas, Esther Barrionuevo, Maria Jose Torres, Inmaculada Andreu, Miguel Ángel Miranda, Gabriela Canto, Miguel Blanca P53 Hypersensitivity to paracetamol according to the new classification of hypersensitivity to NSAIDs Gabija Didžiokaite, Olesia Gaidej, Simona Kašinskaite, Violeta Kvedariene P54 Ibuprofen and other aryl propionic derivates can induce immediate selective hypersensitivity responses Diana Perez-Alzate, Natalia Blanca-López, Maria Isabel Garcimartin, Inmaculada Doña, Maria Luisa Somoza, Cristobalina Mayorga, Maria Jose Torres, Gador Bojas, Jose Antonio Cornejo-Garcia, Maria Gabriela Canto, Miguel Blanca P55 Subjects developing immediate responses to several NSAIDs can be selective with good tolerance to ASA Natalia Blanca-Lopez, Diana Pérez-Alzate, Francisco Javier Ruano Perez, Inmaculada Doña, Maria Luisa Somoza, Inmaculada Andreu, Miguel Angel Miranda, Cristobalina Mayorga, Maria Jose Torres, Jose Antonio Cornejo-Garcia, Miguel Blanca, Maria Gabriela Canto P56 Utility of low-dose oral aspirin challenges for diagnosis of aspirin exacerbated respiratory disease Elina Jerschow, Teresa Pelletier, Zhen Ren, Golda Hudes, Marek Sanak, Esperanza Morales, Victor Schuster, Simon D. Spivack, David Rosenstreich Poster Walk 7: NSAID 2 (P57–P65) P57 Alternate regulation of cyclooxygenase-2 (COX-2) MRNA expression may predispose patients to aspirin-induced exacerbations Renato Erzen, Mira Silar, Nissera Bajrovic, Matija Rijavec, Mihaela Zidarn, Peter Korosec P58 Anaphylaxis to diclofenac: what about the underlying mechanism? Leonor Carneiro-Leão, Fabrícia Carolino, Luís Amaral, Carmen Botelho, Eunice Dias-Castro, Josefina Cernadas P59 COX-2 inhibitors: are they always a safe alternative in hypersensitivity to nonsteroidal anti-inflammatory drugs? Luis Amaral, Fabricia Carolino, Eunice Castro, Josefina Cernadas P60 Management of patients with history of NSAIDs reactions prior to coronary angioplasty Mona Al-Ahmad, Tito Rodriguez P61 Oral drug challenge with non-steroidal anti-inflammatory drug under spirometric control: clinical series of 110 patients João Pedro Azevedo, Emília Faria, Beatriz Tavares, Frederico Regateiro, Ana Todo-Bom P62 Prevalence and incidence of analgesic hypersensitivity reactions in Colombia Pablo Andrés Miranda, Bautista De La Cruz Hoyos P63 Recent endoscopic sinus surgery lessens reactions during aspirin challenge in patients with aspirin exacerbated respiratory disease Teresa Pelletier, Waleed Abuzeid, Nadeem Akbar, Marc Gibber, Marvin Fried, Weiguo Han, Taha Keskin, Robert Tamayev, Golda Hudes, Simon D. Spivack, David Rosenstreich, Elina Jerschow P64 Safe use of imidazole salycilate in a case of multiple NSAIDs induced urticaria-angioedema Elisa Boni, Marina Russello, Marina Mauro P65 Selective hypersensitivity reactions to ibuprofen—seven years experience Marta Ferreira Neto Poster Walk 8: Epidemiological methods (P66–P72) P66 Allopurinol hypersensitivity: a 7-year review Lise Brosseron, Daniela Malheiro, Susana Cadinha, Patrícia Barreira, J. P. Moreira Da Silva P67 Antibiotic allergy labelling is associated with increased hospital readmission rates in Australia Brittany Knezevic, Dustin Sprigg, Michelle Trevenen, Jason Seet, Jason Trubiano, William Smith, Yogesh Jeelall, Sandra Vale, Richard Loh, Andrew Mclean-Tooke, Michaela Lucas P68 Experts’ opinions on severe cutaneous adverse drug reactions-report of a survey from the 9th international congress on cutaneous adverse drug reactions 2015 Roni P. Dodiuk-Gad, Cristina Olteanu, Wen-Hung Chung, Neil H. Shear P69 HLA-A*31-positive AGEP with carbamazepine use and other severe cutaneous adverse drug reactions (SCARs) detected by electronic medical records screening Sabine Müller, Ursula Amstutz, Lukas Jörg, Nikhil Yawalkar, Stephan Krähenbühl P70 Patients with suspected drug allergy: a specific psychological profile? Eunice Dias-Castro, Ana Leblanc, Laura Ribeiro, Josefina R. Cernadas P71 Use of an electronic device and a computerized mathematic algorithm to detect the allergic drug reactions through the analysis of heart rate variability Arantza Vega, Raquel Gutierrez Rivas, Ana Alonso, Juan Maria Beitia, Belén Mateo, Remedios Cárdenas, Juan Jesus Garcia-Dominguez P72 Variation in ERAP influences risk for HLA-B*57:01 positive abacavir hypersensitivity Rebecca Pavlos, Kaija Strautins, Ian James, Simon Mallal, Alec Redwood, Elizabeth Phillips Poster Walk 9: DRESS/AGEP (P73–P81) P73 A clinical case of DRESS syndrome in a child after administration of amoxicillin-clavulanic acid Rita Aguiar, Anabela Lopes, Ana Neves, Maria Do Céu Machado, M. A. Pereira-Barbosa P74 Acute generalized exanthematous pustulosis (AGEP) induced by mesalazine, reliable and oftenly used drug to treat inflammatory bowel disease Ceyda Tunakan Dalgiç, Emine Nihal Mete Gökmen, Fatma Düsünür Günsen, Gökten Bulut, Fatma Ömür Ardeniz, Okan Gülbahar, Ali Kokuludag, Aytül Zerrin Sin P75 Changes of blood plasmacytoid dendritic cells, myeloid dendritic cells, and basophils during the acute stage of drug reaction with eosinophilia and systemic symptoms (DRESS) and other drug eruptions Shao-Hsuan Hsu, Yung-Tsu Cho, Che-Wen Yang, Kai-Lung Chen, Chia-Yu Chu P76 Characterization of isoniazid/rifampicin-specific t-cell responses in patients with DRESS syndrome Young-Min Ye, Gyu-Young Hur, Hae-Sim Park, Seung-Hyun Kim P77 DRESS syndrome secondary to sulfasalazine with delayed TEN: a case presentation Syed Ali, Michaela Lucas, Peter N. Hollingsworth, Andrew P. C. Mclean-Tooke P78 Drug rash with eosinophilia and systemic symptoms (DRESS) features according to the culprit drug Zohra Chadly, Nadia Ben Fredj, Karim Aouam, Haifa Ben Romdhane, Naceur A. Boughattas, Amel Chaabane P79 Drug reaction with eosinophilia and systemic symptoms induced by allopurinol: not always easy to diagnose Marina Lluncor Salazar, Beatriz Pola, Ana Fiandor, Teresa Bellón, Elena Ramírez, Javier Domínguez Ortega, Santiago Quirce, Rosario Cabañas P80 Drug reaction with eosinophilia and systemic symptoms syndrome induced by two drugs simultaneously: a case report Krasimira Baynova, Marina Labella, Manuel Prados P81 The drug reaction with eosinophilia and systemic symptoms (DRESS) induced by the second-line antituberculosis drugs and Epstein–Barr virus infection Agne Ramonaite, Ieva Bajoriuniene, Brigita Sitkauskiene, Raimundas Sakalauskas Poster Walk 10: Miscellaneous drug hypersensitivity (P82–P91) P82 A case of cycloserine-induced lichenoid drug eruption confirmed with a lymphocatye transformation test Jae-Woo Kwon, Shinyoung Park P83 Allergic reaction to topical eye drops: 5 years’ retrospective study in a drug allergy unit Diana Silva, Leonor Carneiro Leão, Fabricia Carolino, Eunice Castro, Josefina Cernadas P84 Allergy to heparins Diana Perez-Alzate, Natalia Blanca-López, Maria Luisa Somoza Alvarez, Maria Garcimartin, Maria Vazquez De La Torre, Francisco Javier Ruano Pérez, Elisa Haroun, Gabriela Canto Diez P85 Allopurinol-induced adverse drug reactions Katinka Ónodi-Nagy, Ágnes Kinyó, Lajos Kemény, Zsuzsanna Bata-Csörgo P86 Analysis of a population with immediate hypersensitivity to corticosteroids: an 11 year review Joana Sofia Pita, Emília Faria, Rosa Anita Fernandes, Ana Moura, Nuno Sousa, Carmelita Ribeiro, Carlos Loureiro, Ana Todo Bom P87 Anaphylaxis against mivacurium in a 12-months old boy at first-time exposure Wolfgang Pfützner P88 Antihistamine-exacerbated chronic spontaneous urticaria: a paradox? Nadine Marrouche, Clive Grattan P89 Anti-osteoporotic agents-induced cutaneous adverse drug reactions in Asians Yu-En Chen, Chun-Bing Chen, Wen-Hung Chung, Yu-Ping Hsiao, Chia-Yu Chu P90 Diagnosis of allergic reactions to eye drops Maria Vazquez De La Torre, Natalia Blanca-Lopez, Diana Perez-Alzate, Maria Isabel Garcimartin, Francisco Javier Ruano, Maria Luisa Somoza, Elisa Haroun, Gabriela Canto P91 Diagnostic approach in suspected hypersensitivity reactions to corticosteroids Fabrícia Carolino, Eunice Dias De Castro, Josefina R. Cernadas

Published
2016

20. 6th International Symposium on Molecular Allergology (ISMA)

Author

Hilger, Christiane, primary, Swiontek, Kyra, additional, Fischer, Jörg, additional, Hentges, François, additional, Lehners, Christiane, additional, Morisset, Martine, additional, Eberlein, Bernadette, additional, Biedermann, Tilo, additional, Ollert, Markus, additional, Wildner, Sabrina, additional, Stemeseder, Teresa, additional, Freier, Regina, additional, Briza, Peter, additional, Lang, Roland, additional, Batanero, Eva, additional, Villalba, Mayte, additional, Lidholm, Jonas, additional, Hawranek, Thomas, additional, Ferreira, Fatima, additional, Brandstetter, Hans, additional, Gadermaier, Gabriele, additional, Moingeon, Philippe, additional, Groeme, Rachel, additional, Bouley, Julien, additional, Bordas, Véronique, additional, Le Mignon, Maxime, additional, Bussières, Laetitia, additional, Lautrette, Aurélie, additional, Mascarell, Laurent, additional, Lombardi, Vincent, additional, Baron-Bodo, Véronique, additional, Chabre, Henri, additional, Batard, Thierry, additional, Nony, Emmanuel, additional, De Amicis, Karine Marafigo, additional, Watanabe, Alexandra Sayuri, additional, Figo, Daniele Danella, additional, Dos Santos-Pinto, José Roberto Aparecido, additional, Palma, Mario Sergio, additional, Castro, Fabio Fernandes Morato, additional, Kalil, Jorge, additional, Wohlschlager, Therese, additional, Ferreira-Briza, Fatima, additional, Santos, Keity Souza, additional, Faber, Margaretha, additional, Van Gasse, Athina, additional, Sabato, Vito, additional, Hagendorens, Margo M., additional, Bridts, Chris H., additional, De Clerck, Luc S., additional, Perales, Araceli Diaz, additional, Ebo, Didier, additional, Zavadakova, Petra, additional, Buchwalder, Aurélie, additional, Rebeaud, Fabien, additional, Märki, Iwan, additional, Gepp, Barbara, additional, Lengger, Nina, additional, Möbs, Christian, additional, Pfützner, Wolfgang, additional, Radauer, Christian, additional, Bohle, Barbara, additional, Galvao, Clovis Eduardo, additional, Santos-Pinto, Jose Roberto Aparecido, additional, Schwager, Christian, additional, Kull, Skadi, additional, Schocker, Frauke, additional, Behrends, Jochen, additional, Becker, Wolf-Meinhard, additional, Jappe, Uta, additional, Mastrorilli, Carla, additional, Tripodi, Salvatore, additional, Caffarelli, Carlo, additional, Asero, Riccardo, additional, Dondi, Arianna, additional, Ricci, Giampaolo, additional, Dascola, Carlotta Povesi, additional, Calamelli, Elisabetta, additional, Di Rienzo Businco, Andrea, additional, Bianchi, Annamaria, additional, Frediani, Tullio, additional, Verga, Carmen, additional, Iacono, Iride Dello, additional, Peroni, Diego, additional, Pingitore, Giuseppe, additional, Bernardini, Roberto, additional, Matricardi, Paolo Maria, additional, Hofer, Heidi, additional, Asam, Claudia, additional, Hauser, Michael, additional, Himly, Martin, additional, Ebner, Christof, additional, Lemoine, Pierrick, additional, Jain, Karine, additional, Abiteboul, Kathy, additional, Arvidsson, Monica, additional, Rak, Sabina, additional, Mota, Inês, additional, Garcia, Filipe Benito, additional, Gaspar, Angela, additional, Arêde, Cristina, additional, Piedade, Susana, additional, Sampaio, Graça, additional, Pires, Graça, additional, Borrego, Luís Miguel, additional, Santa-Marta, Cristina, additional, Morais-Almeida, Mário, additional, Popescu, Florin-Dan, additional, Vieru, Mariana, additional, Secureanu, Florin-Adrian, additional, Fernandes, Rosa Anita Rodrigues, additional, Carrapatoso, Isabel, additional, Gomes, Raquel, additional, Pereira, Celso, additional, Todo-Bom, Ana, additional, De Basoa, María Cecilia Martín Fernández, additional, Regio, Javier Barrios, additional, De Castro Cordova, Juan, additional, Ferreiro, Antón Fernández, additional, Tsilochristou, Olympia, additional, Perna, Serena, additional, Schwarz, Alina, additional, Rohrbach, Alexander, additional, Cappella, Antonio, additional, Hatzler, Laura, additional, Bauer, Carl-Peter, additional, Hoffmann, Ute, additional, Forster, Johannes, additional, Zepp, Fred, additional, Schuster, Antje, additional, D’amelio, Raffael, additional, Wahn, Ulrich, additional, Keil, Thomas, additional, Lau, Susanne, additional, Apoil, Pol André, additional, Mailhol, Claire, additional, Broué-Chabbert, Anne, additional, Juchet, Agnès, additional, Didier, Alain, additional, Carrer, Elodie, additional, Lanot, Thomas, additional, Blancher, Antoine, additional, Kurtaj, Almedina, additional, Hillebrand, Christoph, additional, Fichtinger, Gerda, additional, Danzer, Martin, additional, Gabriel, Christian, additional, Thalhamer, Theresa, additional, Scheiblhofer, Sandra, additional, Thalhamer, Josef, additional, Weiss, Richard, additional, Wolf, Martin, additional, Pichler, Ulrike, additional, Twaroch, Teresa, additional, Yokoi, Hidenori, additional, Takai, Toshiro, additional, Didierlaurent, Alain, additional, Mari, Adriano, additional, Behrendt, Heidrun, additional, Neubauer, Angela, additional, Stolz, Frank, additional, Ferreira, Fátima, additional, Wallner, Michael, additional, Carvalho, Sara, additional, Lourenço, Tatiana, additional, Cosme, Joana, additional, Duarte, Fátima Cabral, additional, Santos, Amélia Spínola, additional, Costa, Ana Célia, additional, Barbosa, Manuel Pereira, additional, Klinglmayr, Eva, additional, Schweidler, Bettina, additional, Lueftenegger, Lisa, additional, Moser, Stephanie, additional, Doppler, Patrick, additional, Oostingh, Gertie J., additional, Bathke, Arne, additional, Zumbach, Joerg, additional, Panzner, Petr, additional, Vachova, Martina, additional, Vlas, Tomas, additional, Maly, Marek, additional, Posa, Daniela, additional, Hofmaier, Stephanie, additional, Stock, Philippe, additional, Grabenhenrich, Linus, additional, Chen, Kuan-Wei, additional, Resch, Yvonne, additional, Vrtala, Susanne, additional, Valenta, Rudolf, additional, Abramidze, Tamar, additional, Lomidze, Nino, additional, Gotua, Maia, additional, Dapkeviciute, Austeja, additional, Einikyte, Ruta, additional, Norkuniene, Jolita, additional, Skrickiene, Laima, additional, Miskiniene, Asta, additional, Kvedariene, Violeta, additional, Schiener, Maximilian, additional, Moreno-Aguilar, Carmen, additional, Pietsch, Gunilla, additional, Intyre, Mareike Mc, additional, Schwarze, Lea, additional, Rußkamp, Dennis, additional, Spillner, Edzard, additional, Darsow, Ulf, additional, Schmidt-Weber, Carsten, additional, Blank, Simon, additional, Longé, Cyril, additional, Brazdova, Andrea, additional, Brunet, Jean-Louis, additional, Schwartz, Claire, additional, Girodet, Bruno, additional, Lavaud, François, additional, Birnbaum, Joelle, additional, Thi, Nhân Pham, additional, Duchateau, Magalie, additional, Chamot-Rooke, Julia, additional, Guilloux, Laurence, additional, Selva, Marie-Ange, additional, Couderc, Rémy, additional, Sénéchal, Hélène, additional, Sutra, Jean-Pierre, additional, Poncet, Pascal, additional, Augustin, Steffen, additional, Pump, Linda, additional, Wald, Martin, additional, Eichhorn, Thomas, additional, Fischer, Frank, additional, Willers, Christoph, additional, Miehe, Michaela, additional, Plum, Melanie, additional, Wolf, Sara, additional, Jabs, Frederic, additional, Raiber, Tim, additional, Bantleon, Frank, additional, Seismann, Henning, additional, Jakob, Thilo, additional, Apostolovic, Danijela, additional, Tran, Anh Thu, additional, Sanchez-Vidaurre, Sara, additional, Velickovic, Tanja Cirkovic, additional, Starkhammar, Maria, additional, Hamsten, Carl, additional, Van Hage, Marianne, additional, Dubiela, Pawel, additional, Humeniuk, Piotr, additional, Pfeifer, Sabine, additional, Bublin, Merima, additional, Borowski, Tomasz, additional, Hoffmann-Sommergruber, Karin, additional, Verschuren, Martie C. M., additional, Bastiaan-Net, Shanna, additional, Depoortere, Defien, additional, Foetisch, Kay, additional, Scheurer, Stephan, additional, Wichers, Harry J, additional, Noij, Theo, additional, Van Uden, Nikki M.E., additional, Vandenberghe, Karel, additional, Wichers, Harry J., additional, Noij, Theo H. M., additional, Roulias, Anargyros, additional, Parigiani, Maria Alejandra, additional, Ahammer, Linda, additional, Grutsch, Sarina, additional, Tollinger, Martin, additional, Moya, Raquel, additional, López-Matas, Mª Angeles, additional, Reyes, Raquel, additional, Carnés, Jerónimo, additional, Larré, Colette, additional, Rogniaux, Hélène, additional, Lupi, Roberta, additional, Denery-Papini, Sandra, additional, Pablos, Isabel Maria, additional, Eichhorn, Stephanie, additional, Machado, Yoan, additional, Park, Jung-Won, additional, Arora, Naveen, additional, Vieths, Stefan, additional, Tanaka, Charlene, additional, Pineau, Florence, additional, Drouet, Martine, additional, Beaudouin, Etienne, additional, Altenbach, Susan, additional, Mameri, Hamza, additional, Brossard, Chantal, additional, Gaudin, Jean Charles, additional, Moneret-Vautrin, Denise Anne, additional, Paty, Evelyne, additional, Tranquet, Olivier, additional, Masci, Stefania, additional, Moneret-Vautrin, Denise-Anne, additional, Petersen, Arnd, additional, Böttger, Marisa, additional, Rennert, Sandra, additional, Krause, Susanne, additional, Ernst, Martin, additional, Gutsmann, Thomas, additional, Bauer, Johann, additional, Lindner, Buko, additional, Koppelman, Stef, additional, Jayasena, Shyamali, additional, Luykx, Dion, additional, Schepens, Erik, additional, De Jong, Govardus, additional, Isleib, Tom, additional, Nordlee, Julie, additional, Baumert, Joe, additional, Taylor, Steve, additional, Maleki, Soheila, additional, Palladino, Chiara, additional, Sirvent, Sofía, additional, Angelina, Alba, additional, Eiwegger, Thomas, additional, Palomares, Oscar, additional, Breiteneder, Heimo, additional, Claude, Mathilde, additional, Bouchaud, Grégory, additional, Bodinier, Marie, additional, Korte, Robin, additional, Bräcker, Julia, additional, Brockmeyer, Jens, additional, Satoh, Rie, additional, Teshima, Reiko, additional, Tscheppe, Angelika, additional, Palmberger, Dieter, additional, Grabherr, Reingard, additional, Raith, Marianne, additional, Sonnleitner, Linda, additional, Zach, Doris, additional, Woroszylo, Konrad, additional, Focke-Tejkl, Margit, additional, Wank, Herbert, additional, Graf, Thorsten, additional, Kuehn, Annette, additional, Swoboda, Ines, additional, Huber, Sara, additional, Gay-Crosier, Fabienne, additional, Polak, Dominika, additional, Nagl, Birgit, additional, Kitzmüller, Claudia, additional, Samadi, Nazanin, additional, Geyeregger, Rene, additional, Jahn-Schmid, Beatrice, additional, Gomez, Ariel, additional, Haka, Jaana, additional, Hattara, Liisa, additional, Heikkinen, Marika, additional, Niemi, Merja H, additional, Rouvinen, Juha, additional, Saviranta, Petri, additional, Mattila, Pekka, additional, Takkinen, Kristiina, additional, Laukkanen, Marja-Leena, additional, Pablos, Isabel, additional, Kastner, Bianca, additional, Silar, Mira, additional, Selb, Julij, additional, Kogovsek, Rok, additional, Kosnik, Mitja, additional, Korosec, Peter, additional, Pestana, Leticia, additional, Melo, Alcinda Campos, additional, Mendes, Ana, additional, Pedro, Maria Elisa, additional, Santos, Maria Conceição Pereira, additional, Bienvenu, Françoise, additional, Goursaud, Claire, additional, Garnier, Lorna, additional, Jacquenet, Sandrine, additional, Degaud, Michaël, additional, Viel, Sébastien, additional, Barre, Annick, additional, Rougé, Pierre, additional, Bienvenu, Jacques, additional, Vitte, Joana, additional, Bensalah, Amel, additional, Cleach, Isabelle, additional, Mousseau, Laurent, additional, Agabriel, Chantal, additional, Liabeuf, Valérie, additional, Birnbaum, Joëlle, additional, Mège, Jean-Louis, additional, Gardner, James, additional, Gandhi, Minal, additional, Kariyawasam, Harsha, additional, Rotiroti, Giuseppina, additional, Regateiro, Frederico, additional, Faria, Emília, additional, Schmid, Johannes Martin, additional, Dahl, Ronald, additional, Hoffmann, Hans Juergen, additional, Pestana, Letícia, additional, Silva, Diana, additional, Vieira, Teresa, additional, Pereira, Ana Maria, additional, Moreira, André, additional, Delgado, Luís, additional, Prates, Sara, additional, Alves, Cátia, additional, Finelli, Elena, additional, Pinto, Paula Leiria, additional, Cardoso, Bárbara Kong, additional, Cruz, Cíntia, additional, Semedo, Filipa, additional, Tomaz, Elza, additional, Inácio, Filipe, additional, Maity, Santanu, additional, Baricevic-Jones, Ivona, additional, Marsh, Justin T., additional, Johnson, Phil E., additional, Balasundaram, Anuradha, additional, Hope, Anya-May, additional, Taekema, Aafke, additional, Simpson, Angela, additional, Semic-Jusufagic, Aida, additional, Clare Mills, E. N., additional, Nelly, Gourdon Dubois, additional, Laetitia, Sellam, additional, Bruno, Pereira, additional, Elodie, Michaud, additional, Khaled, Messaoudi, additional, Bertrand, Evrard, additional, Jean-Luc, Fauquert, additional, Goodman, Richard E., additional, Plata, Elena Rodríguez, additional, Amaral, Luis, additional, Bartolomé, Borja, additional, Coimbra, Alice, additional, Placido, Jose L, additional, Ganea, Carmen Saviana, additional, Costello, Carol Ann, additional, Sorensen, Martin, additional, Mills, Clare, additional, Rogers, Adrian, additional, Otherhals, Aage, additional, Kalic, Tanja, additional, Ellinger, Isabella, additional, Waltl, Eva, additional, Niederberger-Leppin, Verena, additional, Szczepankiewicz, Dawid, additional, Pruszynska-Oszmalek, Ewa, additional, Skrzypski, Marek, additional, Nowak, Krzysztof W., additional, Szczepankiewicz, Aleksandra, additional, Jang, Gwang-Cheon, additional, Markovic, Iva, additional, Borowski, Andreas, additional, Vetter, Tina, additional, Wohlmann, Andreas, additional, Kuepper, Michael, additional, Friedrich, Karlheinz, additional, Gracia, Ibon Eguiluz, additional, Bosco, Anthony, additional, Dollner, Ralph, additional, Melum, Guro Reinholt, additional, Jones, Anya C, additional, Lexberg, Maria, additional, Holt, Patrick G, additional, Bækkevold, Espen Sønderaal, additional, Jahnsen, Frode Lars, additional, Sobkowiak, Paulina, additional, Rachel, Marta, additional, Narozna, Beata, additional, Jenerowicz, Dorota, additional, Swiatowy, Witold, additional, Breborowicz, Anna, additional, Nestelbacher, Reinhard, additional, and Fukui, Hiroyuki, additional

Published
2016
Full Text
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22. 7th Drug hypersensitivity meeting: part two

Author

Elera, Javier Dionicio, primary, Boteanu, Cosmin, additional, Blanco, Maria Aranzazu Jimenez, additional, Gonzalez-Mendiola, Rosario, additional, García, Irene Carrasco, additional, Alvarez, Antonio, additional, Martinez, Jose Julio Laguna, additional, Garrido, Jaume Martí, additional, Barona, Carla Torán, additional, Chorda, Carolina Perales, additional, Salgueiro, Ramón López, additional, Palacios, Miguel Díaz, additional, De Rojas, Dolores Hernández Fernández, additional, Acar, Emre Ali, additional, Aktas, Ayse, additional, Ermertcan, Aylin Türel, additional, Temiz, Peyker, additional, Lin, Chien-Yio, additional, Hui, Chung-Yee Rosaline, additional, Chang, Ya-Ching, additional, Yang, Chih-Hsun, additional, Chung, Wen-Hung, additional, Carolino, Fabrícia, additional, Silva, Diana, additional, De Castro, Eunice Dias, additional, Cernadas, Josefina R., additional, Ensina, Luis Felipe, additional, Aranda, Carolina, additional, Nunes, Ines Camelo, additional, Lacerda, Alex, additional, Martins, Ana Maria, additional, Goudouris, Ekaterini, additional, Ribeiro, Marcia, additional, Da Silva Franco, José Francisco, additional, Queiroz, Leandra, additional, Solé, Dirceu, additional, Dalgiç, Ceyda Tunakan, additional, Sin, Aytül Zerrin, additional, Günsen, Fatma Düsünür, additional, Bulut, Gökten, additional, Ardeniz, Fatma Ömür, additional, Gülbahar, Okan, additional, Gökmen, Emine Nihal Mete, additional, Kokuludag, Ali, additional, De Francisco, Ana M. Montoro, additional, De Vicente Jiménez, Talía Mª, additional, Mendoza Parra, Adriana M., additional, Burgos Pimentel, Angella M., additional, Luque, Amelia García, additional, Amaral, Luis, additional, Leão, Leonor Carneiro, additional, Pinto, Nicole, additional, Belo, Joana, additional, Marques, João, additional, Carreiro-Martins, Pedro, additional, Leiria-Pinto, Paula, additional, Chaabane, Amel, additional, Romdhane, Haifa Ben, additional, Fredj, Nadia Ben, additional, Chadly, Zohra, additional, Boughattas, Naceur A., additional, Aouam, Karim, additional, Uyttebroek, Astrid P., additional, Bridts, Chris H., additional, Romano, Antonino, additional, Ebo, Didier G., additional, Sabato, Vito, additional, Lopes, Anabela, additional, Cosme, Joana, additional, Aguiar, Rita, additional, Lourenço, Tatiana, additional, Paes, Maria-João, additional, Spínola-Santos, Amélia, additional, Pereira-Barbosa, Manuel, additional, Cruz, Cíntia Rito, additional, Dos Reis, Rute Pereira, additional, Tomaz, Elza, additional, Pires, Ana Paula, additional, Inácio, Filipe, additional, Benito-Garcia, Filipe, additional, Mota, Inês, additional, Correia, Magna, additional, Gaspar, Ângela, additional, Chambel, Marta, additional, Piedade, Susana, additional, Morais-Almeida, Mário, additional, Nakonechna, Alla, additional, Antipkin, Yurij, additional, Umanets, Tetiana, additional, Pineda, Fernando, additional, Arribas, Francisca, additional, Lapshyn, Volodymyr, additional, Miranda, Pablo Andrés, additional, De La Cruz Hoyos, Bautista, additional, Blanco, Aranzazu Jimenez, additional, Del Pozo, Marta, additional, Vultaggio, Alessandra, additional, Nencini, Francesca, additional, Pratesi, Sara, additional, Matucci, Andrea, additional, Maggi, Enrico, additional, Cegec, Ivana, additional, Nahal, Danica Juricic, additional, Turk, Viktorija Erdeljic, additional, Aumiler, Matea Radacic, additional, Ausperger, Ksenija Makar, additional, Kraljickovic, Iva, additional, Simic, Iveta, additional, Yamaguchi, Yukie, additional, Watanabe, Tomoya, additional, Satoh, Megumi, additional, Tanegashima, Tomohiko, additional, Oda, Kayoko, additional, Wada, Hidefumi, additional, Aihara, Michiko, additional, Lee, Jaechun Jason, additional, Choi, Jay Chol, additional, Lee, Hwa Young, additional, Fernandes, Rosa-Anita Rodrigues, additional, Faria, Emília, additional, Pita, Joana, additional, Sousa, Nuno, additional, Ribeiro, Carmelita, additional, Carrapatoso, Isabel, additional, Bom, Ana Todo, additional, Rodolfo, Ana, additional, Dias-Castro, Eunice, additional, Voronova, Marina, additional, Valle, Diana Kury, additional, Coronel, Verónica Pacheco, additional, Chordá, Carolina Perales, additional, Madamba, Roselle Catherine Yu, additional, Ferrer, Marta, additional, Goikoetxea, Maria Jose, additional, D’Amelio, Carmen, additional, Bernad, Amalia, additional, Vega, Olga, additional, Gastaminza, Gabriel, additional, Bibián, Beatriz Pola, additional, Salazar, Marina Lluncor, additional, Vilà-Nadal, Gemma, additional, Roman, Ana María Fiandor, additional, Ortega, Javier Dominguez, additional, Muñoz, Miguel Gonzalez, additional, Gancedo, Santiago Quirce, additional, Moreno, Maria Rosario Cabañas, additional, Hofmeier, Kathrin Scherer, additional, Barzylovych, Vladyslava, additional, Pola, Beatriz, additional, Lluncor, Marina, additional, Fiandor, Ana, additional, Bellón, Teresa, additional, Domínguez, Javier, additional, Quirce, Santiago, additional, Yang, Min-Suk, additional, Kim, Sun-Sin, additional, Kim, Sae-Hoon, additional, Kang, Hye-Ryun, additional, Park, Heung-Woo, additional, Cho, Sang-Heon, additional, Min, Kyung-Up, additional, Chang, Yoon-Seok, additional, Delahaye, Clémence, additional, Flabbee, Jenny, additional, Waton, Julie, additional, Bauvin, Olivia, additional, Barbaud, Annick, additional, Fadhel, Najah Ben, additional, Gulin, Sandra Jerkovic, additional, Chiriac, Anca, additional, Cardoso, Bárbara Kong, additional, Viseu, Regina, additional, Moreira, Ana, additional, Cadinha, Susana, additional, Neves, Ana Castro, additional, Barreira, Patrícia, additional, Malheiro, Daniela, additional, Da Silva, J. P. Moreira, additional, Jurakic-Toncic, Ružica, additional, Ljubojevic, Suzana, additional, Turcic, Petra, additional, Gilissen, Liesbeth, additional, Huygens, Sara, additional, Goossens, An, additional, Andreu, Inmaculada, additional, Romero, Alicia Martinez, additional, Cabezas, Pau Gomez, additional, Parejo, Pedro Ayuso, additional, Del Carmen Plaza-Serón, Maria, additional, Doña, Inmaculada, additional, Blanca-López, Natalia, additional, Flores, Carlos, additional, Galindo, María Luisa, additional, Molina, Ana, additional, Perkins, James Richard, additional, Cornejo-García, José Antonio, additional, García-Agúndez, José Augusto, additional, García-Martín, Elena, additional, Campo, Paloma, additional, Canto, María Gabriela, additional, Blanca, Miguel, additional, Guéant-Rodríguez, Rosa María, additional, Jurado-Escobar, Raquel, additional, Barrionuevo, Esther, additional, Salas, María, additional, Canto, Gabriela, additional, Guéant, Jean-Louis, additional, Usui, Toru, additional, Tailor, Arun, additional, Faulkner, Lee, additional, Farrell, John, additional, Alfirevic, Ana, additional, Kevin Park, B., additional, Naisbitt, Dean J., additional, Trelles, Oswaldo, additional, Guerrero, María Auxiliadora, additional, Upton, Alex, additional, Ueta, Mayumi, additional, Sawai, Hiromi, additional, Sotozono, Chie, additional, Tokunaga, Katushi, additional, Kinoshita, Shigeru, additional, Sukasem, Chonlaphat, additional, Satapornpong, Patompong, additional, Tempark, Therdpong, additional, Rerknimitr, Pawinee, additional, Pairayayutakul, Kulprapat, additional, Klaewsongkram, Jettanong, additional, Koomdee, N., additional, Jantararoungtong, T., additional, Santon, S., additional, Puangpetch, A., additional, Intusoma, U., additional, Tassaneeyakul, W., additional, Theeramoke, V., additional, Ramirez, Elena, additional, Borobia, Alberto Manuel, additional, Tong, Hoi, additional, Castañer, Jose Luis, additional, De Abajo, Francisco José, additional, Galvao, Violeta Régnier, additional, Pavlos, Rebecca, additional, Mckinnon, Elizabeth, additional, Williams, Kristina, additional, Beeghly-Fadiel, Alicia, additional, Redwood, Alec, additional, Phillips, Elizabeth, additional, Castells, Mariana, additional, Boni, Elisa, additional, Russello, Marina, additional, Mauro, Marina, additional, Ue, Kok Loong, additional, Rutkowski, Krzysztof, additional, Gomis, Victor Soriano, additional, Ferre, Jorge Frances, additional, Rodriguez, Angel Esteban, additional, Reig, Vicente Cantó, additional, Sanchez, Javier Fernandez, additional, Breynaert, Christine, additional, Van Hoeyveld, Erna, additional, Schrijvers, Rik, additional, Irigoyen, Raquel Fuentes, additional, Collado, Daniel, additional, Vida, Yolanda, additional, Najera, Francisco, additional, Perez-Inestrosa, Ezequiel, additional, Mesa-Antunez, Pablo, additional, Mayorga, Cristobalina, additional, Torres, María José, additional, Tannert, Line K., additional, Mortz, Charlotte G., additional, Skov, Per Stahl, additional, Bindslev-Jensen, Carsten, additional, Pfützner, Wolfgang, additional, Dörnbach, Hannah, additional, Visse, Johanna, additional, Rauber, Michele, additional, Möbs, Christian, additional, Elzagallaai, Abdelbaset A., additional, Chow, Lindsey, additional, Abuzgaia, Awatif M., additional, Rieder, Michael J., additional, Trubiano, Jason, additional, Woolnough, Emily, additional, Stautins, Kaija, additional, Cheng, Christina, additional, Kato, Kenichi, additional, Azukizawa, Hiroaki, additional, Hanafusa, Takaaki, additional, Katayama, Ichiro, additional, Fujiyama, Toshiharu, additional, Hashizume, Hideo, additional, Umayahara, Takatsune, additional, Ito, Taisuke, additional, Tokura, Yoshiki, additional, Silar, Mira, additional, Zidarn, Mihaela, additional, Rupnik, Helena, additional, Korosec, Peter, additional, Redwood, Alec James, additional, Strautins, Kaija, additional, White, Katie, additional, Chopra, Abha, additional, Konvinse, Katherine, additional, Leary, Shay, additional, Mallal, Simon, additional, Cabañas, Rosario, additional, Fiandor, Ana María, additional, Sullivan, Andrew, additional, Whitaker, Paul, additional, Peckham, Daniel, additional, Haw, Wei Yann, additional, Polak, Marta E., additional, Mcguire, Carolann, additional, Ardern-Jones, Michael R., additional, Aoyama, Yumi, additional, Shiohara, Tetsuo, additional, Correia, Sara, additional, Gelincik, Asli, additional, Demir, Semra, additional, Sen, Fatma, additional, Bozbey, Hamza Ugur, additional, Olgac, Muge, additional, Unal, Derya, additional, Coskun, Raif, additional, Colakoglu, Bahauddin, additional, Buyuozturk, Suna, additional, Çatin-Aktas, Esin, additional, Deniz, Gunnur, additional, Laguna, Jose Julio, additional, Dionicio, J., additional, Fernandez, Tahia, additional, Olazabal, I., additional, Ruiz, Maria Dolores, additional, Torres, Maria José, additional, Lafuente, Alberto, additional, Núñez, Jorge, additional, Fernández, Tahia Diana, additional, Palomares, Francisca, additional, Fernández, Rubén, additional, Sanchez, Maria Isabel, additional, Fernandez, Tahía, additional, Ruiz, Arturo, additional, Ariza, Adriana, additional, Alonso, Amalia Bernad, additional, Garófalo, Carmen D’Amelio, additional, Matute, Olga Vega, additional, Puga, Marta Ferrer, additional, Lapresa, María José Goikoetxea, additional, Lasarte, Gabriel Gastaminza, additional, Thinnes, Antonia, additional, Merk, Hans F., additional, Baron, Jens Malte, additional, Leverkus, Martin, additional, Balakirski, Galina, additional, Gibson, Andrew, additional, Ogese, Monday, additional, Al-Attar, Zaid, additional, Yaseen, Fiazia, additional, Meng, Xiaoli, additional, Jenkins, Rozalind, additional, Farrel, John, additional, Alhilali, Khetam, additional, Xue, Yanni, additional, Illing, Patricia, additional, Mifsud, Nicole, additional, Fettke, Heidi, additional, Lai, Jeffrey, additional, Ho, Rebecca, additional, Kwan, Patrick, additional, Purcell, Anthony, additional, Ogese, Monday O., additional, Betts, Catherine, additional, Thomson, Paul, additional, Alhaidari, Mohammad, additional, Berry, Neill, additional, O’Neill, Paul M., additional, Alzahrani, Abdulaziz, additional, Azoury, Marie Eliane, additional, Fili, Lucia, additional, Bechara, Rami, additional, Scornet, Noémie, additional, Nhim, Cathy, additional, Weaver, Richard, additional, Claude, Nancy, additional, Joseph, Delphine, additional, Maillere, Bernard, additional, Parronchi, Paola, additional, Pallardy, Marc, additional, Villani, Axel Patrice, additional, Rozières, Aurore, additional, Bensaïd, Benoît, additional, Tardieu, Mathilde, additional, Albert, Floriane, additional, Mutez, Virginie, additional, Baysal, Tugba, additional, Maryanski, Janet, additional, Nicolas, Jean-François, additional, Kanagawa, Osami, additional, Vocanson, Marc, additional, Hung, Shuen-Iu, additional, Harrison, Caroline J., additional, Jenkins, Rosalind E., additional, French, Neil S., additional, Montañez, Maria Isabel, additional, Fernandez, Tahia D., additional, Martin-Serrano, Angela, additional, Torres, Maria Jose, additional, Molina, Noemi, additional, Wood, Sally, additional, Pirmohamed, Munir, additional, Montañez, María Isabel, additional, Martín-Serrano, Ángela, additional, Pérez-Inestrosa, Ezequiel, additional, Pérez-Sala, Dolores, additional, Guzmán, Antonio E., additional, Ko, Tai-Ming, additional, Chen, Yuan-Tsong, additional, Wu, Jer-Yuarn, additional, Sánchez-Gómez, Francisco J., additional, González-Morena, Juan M., additional, Torres, María J., additional, Arreola, Alejandra Monroy, additional, Corona, Jesus Agustin Badillo, additional, Flores, Silvia Mendez, additional, Cherit, Judith Dominguez, additional, Figueroa, Noe Valentin Duran, additional, Flores, Jose Luis Castrejon, additional, Perkins, James, additional, Pérez-Alzate, Diana, additional, Bogas, Gador, additional, Torres, María J, additional, Marti, Luis Mario Tubella, additional, De La Losa, Fernando Pineda, additional, Poves, Francisca Arribas, additional, Lopez, Jaime Tubella, additional, and Santiago, Teodora Lopez, additional

Published
2016
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39. Stable phase post-MI patients have elevated VEGF levels correlated with inflammation markers, but not with atherosclerotic burden.

Author

ErZen, Barbara, Silar, Mira, Sabovic, Miso, ErŽen, Barbara, Šilar, Mira, and Šabovič, Mišo

Abstract

Background: The role of vascular endothelial growth factor (VEGF) in patients in the stable phase after myocardial infarction (MI) has not yet been explored. Therefore, we compared the values of VEGF in post-MI patients with those obtained in healthy controls. Furthermore, we investigated whether the values of VEGF correlate to either inflammation markers or the atherosclerotic burden. Methods: 41 male patients (on average 44 years old) in the stable phase after MI (on average 20.5 months after MI) were recruited, while 25 healthy age-matched males served as controls. Plasma levels of VEGF and several markers of inflammation were measured by standard procedures. The atherosclerotic burden was determined by the angiographic severity of coronary atherosclerosis, endothelial dysfunction (measured by ultrasound measurement of the flow mediated dilation of the brachial artery), the intima-media thickness of the common carotid artery and the ankle-brachial pressure index. Results: VEGF values were significantly elevated in post-MI patients compared to the controls (53.8 ± 42.7 pg/ml vs. 36.3 ± 8.9 pg/ml, p = 0.014). The elevated VEGF values significantly correlated to the (increased) values of the inflammatory molecules interleukin 6 and 8 (r = 0.37, p = 0.017; and r = 0.45, p = 0.003; respectively). In contrast, no correlation was found between VEGF and the parameters of the atherosclerotic burden, although FMD and IMT were significantly impaired in patients. Conclusions: We found that plasma levels of VEGF are increased in the stable phase after MI and correlate with inflammation cytokines, but not with the atherosclerotic burden. Thus, this suggests that increased levels of VEGF are a part of ongoing inflammatory activity. Since VEGF in these patients stimulates neovascularization of inflamed plaques and induces their destabilization, the VEGF level can have an important negative prognostic value. Clearly, further studies are needed to clarify the role of VEGF as a prognostic marker. [ABSTRACT FROM AUTHOR]

Published
2014
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40. The relevance of basophil allergen sensitivity testing to distinguish between severe and mild peanut-allergic children.

Author

Homšak M, Silar M, Berce V, Tomazin M, Skerbinjek-Kavalar M, Celesnik N, Košnik M, and Korošec P

Subjects
Adolescent, Allergens genetics, Child, Child, Preschool, Female, Humans, Immunoglobulin E blood, Male, Peanut Hypersensitivity physiopathology, Recombinant Proteins genetics, Recombinant Proteins metabolism, Allergens immunology, Arachis immunology, Basophils immunology, Peanut Hypersensitivity diagnosis, Peanut Hypersensitivity immunology
Abstract

Background: Peanut sensitization is common in children. However, it is difficult to assess which children will react mildly and which severely. This study evaluated the relevance of basophil allergen sensitivity testing to distinguish the severity of peanut allergy in children., Methods: Twenty-seven peanut-sensitized children with symptoms varying from mild symptoms to severe anaphylaxis underwent peanut CD63 dose-response curve analysis with the inclusion of basophil allergen sensitivity calculation (CD-sens) and peanut component immunoglobulin E (IgE) testing., Results: Eleven children who had experienced anaphylaxis to peanuts showed a markedly higher peanut CD63 response at submaximal allergen concentrations and CD-sens (median 1,667 vs. 0.5; p < 0.0001) than 16 children who experienced a milder reaction. Furthermore, a negative or low CD-sens to peanuts unambiguously excluded anaphylactic peanut allergy. Children with anaphylaxis have higher levels of Ara h 1, 2, 3 and 9 IgE, but comparable levels of IgE to Ara h 8 and whole-peanut extract. The diagnostic specificity calculated with a receiver operating characteristic analysis reached 100% for CD-sens and 73% for Ara h 2., Conclusions: We demonstrated that severe peanut allergy is significantly associated with higher basophil allergen sensitivity. This cellular test should facilitate a more accurate diagnosis of peanut allergy., (© 2013 S. Karger AG, Basel.)

Published
2013
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41. Reply: To PMID 22277204.

Author

Korošec P, Silar M, Zidarn M, and Košnik M

Subjects
Animals, Humans, Activins pharmacology, Respiratory Hypersensitivity immunology, T-Lymphocytes, Helper-Inducer immunology, Transforming Growth Factor beta pharmacology
Published
2012
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42. High sensitivity of CAP-FEIA rVes v 5 and rVes v 1 for diagnosis of Vespula venom allergy.

Author

Korošec P, Valenta R, Mittermann I, Celesnik N, Silar M, Zidarn M, and Košnik M

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Allergens immunology, Animals, Antigens, Plant immunology, Bees, Female, Humans, Hyaluronoglucosaminidase immunology, Hypersensitivity immunology, Immunoglobulin E blood, Insect Proteins immunology, Male, Middle Aged, Phospholipases A immunology, Phospholipases A metabolism, Recombinant Proteins metabolism, Sensitivity and Specificity, Sequence Homology, Amino Acid, Serologic Tests methods, Wasp Venoms adverse effects, Wasp Venoms immunology, Wasps, Young Adult, Allergens metabolism, Antigens, Plant metabolism, Hyaluronoglucosaminidase metabolism, Hypersensitivity diagnosis, Insect Proteins metabolism, Wasp Venoms metabolism
Published
2012
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43. Expressions of topoisomerase IIα and BCRP in metastatic cells are associated with overall survival in small cell lung cancer patients.

Author

Rijavec M, Silar M, Triller N, Kern I, Cegovnik U, Košnik M, and Korošec P

Subjects
ATP Binding Cassette Transporter, Subfamily B, Member 1 genetics, ATP Binding Cassette Transporter, Subfamily G, Member 2, Adenocarcinoma genetics, Adenocarcinoma mortality, Adenocarcinoma pathology, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma, Non-Small-Cell Lung genetics, Carcinoma, Non-Small-Cell Lung mortality, Carcinoma, Non-Small-Cell Lung pathology, Carcinoma, Squamous Cell genetics, Carcinoma, Squamous Cell mortality, Carcinoma, Squamous Cell pathology, Cisplatin administration & dosage, Cyclophosphamide administration & dosage, Epirubicin administration & dosage, Etoposide administration & dosage, Female, Humans, Lung Neoplasms genetics, Lung Neoplasms mortality, Lung Neoplasms pathology, Lymphatic Metastasis, Male, Mediastinal Neoplasms secondary, Middle Aged, Multidrug Resistance-Associated Proteins genetics, Prospective Studies, RNA, Messenger genetics, Real-Time Polymerase Chain Reaction, Small Cell Lung Carcinoma pathology, Survival Rate, Treatment Outcome, Vault Ribonucleoprotein Particles genetics, Vincristine administration & dosage, ATP-Binding Cassette Transporters genetics, Antigens, Neoplasm genetics, DNA Topoisomerases, Type II genetics, DNA-Binding Proteins genetics, Mediastinal Neoplasms genetics, Mediastinal Neoplasms mortality, Neoplasm Proteins genetics, Small Cell Lung Carcinoma genetics, Small Cell Lung Carcinoma mortality
Abstract

The aim of this study was to investigate the mRNA expression levels of multidrug resistance-associated proteins in chemo-naïve metastatic lung cancer cells and to determine the correlation with response to chemotherapy and overall survival. Metastatic cells were obtained by transbronchial fine needle aspiration biopsy of enlarged mediastinal lymph nodes in 14 patients with small cell lung cancer (SCLC) and 7 patients with non-small cell lung cancer (NSCLC). After cytological confirmation of lung cancer type, total RNA was extracted from biopsy samples and reverse transcribed to cDNA, and real-time PCR for the genes of interest [P-glycoprotein (P-gp), multidrug resistance protein 1 (MRP1), breast cancer resistance protein (BCRP), lung resistance protein (LRP) and topoisomerase IIα (TOPIIα)], was performed. We observed significantly decreased expression of BCRP and significantly increased expression of TOPIIα in metastatic SCLC cells compared to NSCLC. Furthermore, in SCLC high topoisomerase IIα and low BCRP expression levels positively correlated with longer overall survival. Our results showed higher expression levels of BCRP as well as lower levels of topoisomerase IIα in chemo-naïve metastatic cells in NSCLC than in SCLC. These results correlate with previous observations that metastatic SCLC cells at the beginning of chemotherapy are potentially more sensitive to chemotherapeutic agents while in metastatic NSCLC cells resistance is usually inherent. We also showed that altered levels of topoisomerase IIα and BCRP in SCLC are important factors that contribute to resistance to chemotherapeutics that interfere with the enzyme and/or DNA and are highly associated with overall survival.

Published
2011
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44. The specificity of tests for anti-beta-lactam IgE antibodies declines progressively with increase of total serum IgE.

Author

Zidarn M, Silar M, Vegnuti M, Korosec P, and Kosnik M

Subjects
Adult, Aged, Aged, 80 and over, Amoxicillin immunology, Ampicillin immunology, Antibody Specificity immunology, Drug Hypersensitivity diagnosis, False Positive Reactions, Female, Humans, Intradermal Tests, Male, Middle Aged, Penicillin G immunology, Penicillin V immunology, Anti-Bacterial Agents immunology, Drug Hypersensitivity immunology, Epitopes immunology, Immunoglobulin E blood, beta-Lactams immunology
Abstract

Background: Immediate allergic reactions to beta-lactam antibiotics are mediated by specific IgE antibodies. The Phadia CAP System FEIA is a commercial method for quantification of specific IgE. We wished to determine anti-beta-lactam IgE antibodies in patients without penicillin allergy but with high levels of total IgE., Methods: Sera from 41 patients (31 with high total IgE, 10 with low total IgE) were analyzed for IgE antibodies specific to penicilloyl G, penicilloyl V, amoxicilloyl and ampicilloyl using the CAP FEIA((R)) method that was available up to 2006. Seven sera that tested positive were rechecked in a new improved system available after 2006., Results: In patients without a history of penicillin allergy, the specificities of commercial tests for anti-beta-lactam IgE antibodies were 100%, 60%, 27% and 20% at total IgE levels of 8-263 kU/l, 500-664 kU/l, 1000-2000 kU/l and > 2000 kU/l, respectively. In seven retested sera, only 2 (28%) were still positive for penicillin-specific IgE antibody., Conclusion: Before 2006, tests for anti-beta-lactam IgE antibody in patients with total IgE > 500 kU/l were probably often false positive. Patients who were diagnosed as penicillin allergic before 2006 solely on the basis of a positive CAP FEIA test for specific IgE should be considered for diagnostic reevaluation.

Published
2009
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45. Carbohydrate epitopes as a cause of cross-reactivity in patients allergic to Hymenoptera venom.

Author

Erzen R, Korosec P, Silar M, Music E, and Kosnik M

Subjects
Adolescent, Adult, Aged, Animals, Antibody Specificity immunology, Female, Humans, Hyaluronoglucosaminidase immunology, Hypersensitivity diagnosis, Intradermal Tests, Male, Middle Aged, Young Adult, Allergens immunology, Bee Venoms immunology, Bites and Stings immunology, Carbohydrates immunology, Cross Reactions physiology, Epitopes immunology, Hymenoptera immunology, Hypersensitivity immunology, Immunoglobulin E immunology, Pollen immunology, Wasp Venoms immunology
Abstract

Background: Among patients with allergy to insect stings, double positivity in tests for IgE antibodies specific to honey bee and wasp venoms is a frequent diagnostic problem. True double sensitization and possible cross-reactivity of venom hyaluronidases and with carbohydrate determinants must be considered in such patients. We studied the frequency of sensitization to carbohydrate determinants and the role of these in double positivity in tests for specific IgE antibodies., Materials and Methods: A group of 66 patients (41 men, 25 women; 16-66 years) with double positivity for wasp and bee venoms were tested in the FEIA inhibition test in order to distinguish true double sensitization from cross-reactivity. Patients were tested for the presence of IgE antibodies specific to oilseed rape (OSR) pollen and MUXF3 allergens, both of which are rich in cross-reacting carbohydrate epitopes., Results: Inhibition tests revealed true double sensitization in 37 patients (56.1%) and cross-reactivity in 29. Among those showing cross-reactivity, five were sensitized to honey bee venom and 24 to wasp venom. The median value of IgE specific for OSR pollen in patients sensitized to honey bee venom was 4.350 IU/ml, in patients sensitized to wasp venom 0.61 IU/ml, and in patients with double sensitization 0.25 IU/ml (P = 0.028, Kruskal-Wallis test). Findings for IgE specific for MUXF3 were similar. Discordance between OSR pollen positivity and MUXF3 positivity was found in 11.1% of the patients., Conclusion: The values of IgE specific for OSR pollen and MUXF3 in patients with primary sensitization to either honey bee venom or wasp venom were significantly higher than in patients with double sensitization. These results confirm that IgE antibodies against carbohydrates epitopes are a frequent cause of double positivity in tests for anti-venom IgE antibodies.

Published
2009
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46. Wasp venom is appropriate for immunotherapy of patients with allergic reaction to the European hornet sting.

Author

Kosnik M, Korosec P, Silar M, Music E, and Erzen R

Subjects
Adult, Animals, Humans, Anaphylaxis therapy, Immunotherapy methods, Insect Bites and Stings immunology, Wasp Venoms immunology, Wasps
Abstract

Aim: To identify whether it is the yellow jacket (Vespula germanica) or European hornet (Vespa crabro) venom that induces sensitization in patients with IgE-mediated allergic reaction to the venom from the sting of a European hornet. Since these patients usually have positive skin tests and specific IgE to all vespid venoms, it would be useful to distinguish cross-reactors from non-cross-reactors to perform immunotherapy with the venom that induced the sensitization., Methods: We performed inhibition tests in 24 patients who had experienced anaphylactic reaction after being stung by a European hornet., Results: Of 24 patients with allergic reaction after Vespa crabro sting, 17 were sensitized only to epitopes of Vespula germanica venom. Only 4 out of 24 patients were sensitized to epitopes completely cross-reactive with Dolichovespula arenaria venom., Conclusion: In Slovenia, the vast majority of patients with anaphylactic reaction to Vespa crabro sting seem to be sensitized to Vespula germanica venom. We consider wasp venom an appropriate immunotherapeutic agent for such patients, except for those with proven primary sensitization to specific epitopes of Vespa crabro venom. Fluorescence enzyme immunoassay inhibition should be considered a convenient tool for the identification of primary sensitization in patients allergic to vespid venoms.

Published
2002

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