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21 results on '"Sihm, Inger"'

2. Myocardial Oxygen Consumption and Efficiency in Aortic Valve Stenosis Patients With and Without Heart Failure

Author

Hansson, Nils Henrik Stubkjær, primary, Sörensen, Jens, additional, Harms, Hendrik Johannes, additional, Kim, Won Yong, additional, Nielsen, Roni, additional, Tolbod, Lars P., additional, Frøkiær, Jørgen, additional, Bouchelouche, Kirsten, additional, Dodt, Karen Kaae, additional, Sihm, Inger, additional, Poulsen, Steen Hvitfeldt, additional, and Wiggers, Henrik, additional

Published
2017
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4. Small artery structure during antihypertensive therapy is an independent predictor of cardiovascular events in essential hypertension

Author

Buus, Niels H., primary, Mathiassen, Ole N., additional, Fenger-Grøn, Morten, additional, Præstholm, Michael N., additional, Sihm, Inger, additional, Thybo, Niels K., additional, Schroeder, Anne P., additional, Thygesen, Kristian, additional, Aalkjær, Christian, additional, Pedersen, Ole L., additional, Mulvany, Michael J., additional, and Christensen, Kent L., additional

Published
2013
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14. Long-term Renal and Cardiovascular Effects of Antihypertensive Treatment Regimens based upon Isradipine, Perindopril and Thiazide.

Author

Sihm, Inger, Thygesen, Kristian, Krusell, Lars Romer, and Lederballe, Ole

Subjects
*HEMODYNAMICS, *ANTIHYPERTENSIVE agents, *HYPERTENSION, *GLOMERULAR filtration rate
Abstract

The aim of this study was to describe the renal function (renal hemodynamics, water and sodium handling) and its relation to cardiovascular structural changes in a population of essential hypertensive patients before and after antihypertensive treatment. Glomerular filtration rate and renal plasma flow were measured by a constant infusion technique. The reference substances used were [[sup 131]I]iodohippurate (Hippuran) and [[sup 125]I]iothalamate. The lithium clearance method was used for measuring renal water and sodium handling. Microalbuminuria was measured. A subcutaneous gluteal biopsy was taken and the media thickness to lumen diameter ratio of small resistance vessels was determined. Left ventricular mass index was determined by echocardiography. Thirty-seven patients with newly diagnosed or poorly controlled essential hypertension were randomized to treatment with regimens based upon either isradipine, perindopril or hydrochlorothiazide-amiloride. Atenolol and hydralazine were added as secondary and tertiary drugs, respectively, when needed for normalization of diastolic blood pressure. Investigations were performed before and after 9 months of normalization of blood pressure. Renal function in untreated hypertensive patients was characterized by increased renal vascular resistance, decreased renal blood flow, normal glomerular filtration fraction and normal serum creatinine. No association was found between peripheral resistance vessel structure in subcutaneous vessels and renal hemodynamic parameters. Patients with severe left ventricular hypertrophy (left ventricular mass >360 g) had lower glomerular filtration fraction, greater renal vascular resistance, lower renal blood flow and increased microalbuminuria in comparison with patients with less pronounced cardiac changes. After 1 year of treatment, which had a profound effect on heart and vessel structure, renal hemodynamics were unchanged in patients receiving antihypertensive treatment regimens based on the ACE inhibitor perindopril or the Ca-antagonist isradipine, whereas renal plasma flow was reduced, glomerular filtration rate preserved and filtration fraction significantly increased in those treated with a regimen based on diuretics. The serum creatinine concentration was decreased in the former group, whereas it was unchanged in the latter two. Significantly detrimental effect on uric acid homeostasis was only found in patients treated with a regimen based on diuretics. [ABSTRACT FROM AUTHOR]

Published
2000
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18. Psychic vulnerability and type-A behavior among young Danish male survivors of acute myocardial infarction

Author

Sihm, Inger, Dehlholm, Gitte, Hansen, Ebbe Stender, Gerdes, Lars Ulrik, and Faergeman, Ole

Abstract

The role of the type-A behavioral pattern (TABP) and psychic vulnerability (PV) as risk factors in coronary heart disease (CHD) was investigated in 54 male acute myocardial infarction survivors less than 55 years old and 77 age-matched healthy controls. No significant difference between patients and controls was found in TABP, as assessed by Jenkins Activity Survey. The frequency of PV was surprisingly high among both patients and controls, but with no difference between groups. However, patients responded positively significantly more often to questions concerning the frequent occurrence of headaches, unexplained rapid heart beat, faintness, or spells of complete exhaustion, unhappiness, a sense of bodily deterioration, depression, anger, extreme shyness or sensitivity, or preference for loneliness. TABP and PV were present simultaneously in 13% of both patients and controls. Twenty-three per cent of patients and 46% of controls exhibited neither PV nor TABP (p<0.01). It is concluded that psychic vulnerability occurs predominantly among subjects not exhibiting the type-A behavioral pattern. Absence of these two behavioral traits is associated with low risk of CHD, whereas liability to negative emotions may prove to be associated with increased coronary risk.

Published
1991
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