10 results on '"Sigrid Pedersen"'
Search Results
2. Genome-wide decrease in DNA methylation in adults with epilepsy treated with modified ketogenic diet: A prospective study
- Author
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Sigrid Pedersen, Magnhild Kverneland, Karl Otto Nakken, Knut Rudi, Per Ole Iversen, Kristina Gervin, and Kaja Kristine Selmer
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Adult ,Epilepsy ,Neurology ,Seizures ,Inositol Phosphates ,Humans ,Neurology (clinical) ,Ketone Bodies ,Prospective Studies ,DNA Methylation ,Diet, Ketogenic - Abstract
Objective The aim of this study was to investigate the impact of the modified ketogenic diet on DNA methylation in adults with epilepsy. Methods In this prospective study, we investigated the genome-wide DNA methylation in whole blood in 58 adults with epilepsy treated with the modified ketogenic for 12 weeks. Patients were recruited from the National Center for Epilepsy, Norway, from March 1, 2011 to February 28, 2017. DNA methylation was analyzed using the Illumina Infinium MethylationEPIC BeadChip array. Analysis of variance and paired t-test were used to identify differentially methylated loci after 4 and 12 weeks of dietary treatment. A false discovery rate approach with a significance threshold of
- Published
- 2022
3. Pyruvate dehydrogenase deficiency
- Author
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Sigrid, Pedersen, Yngve Thomas, Bliksrud, Kaja Kristine, Selmer, and Anette, Ramm-Pettersen
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Diagnosis, Differential ,Dichloroacetic Acid ,Humans ,Pyruvate Dehydrogenase Complex ,Thiamine ,Diet, Ketogenic ,Pyruvate Dehydrogenase Complex Deficiency Disease - Abstract
Pyruvate dehydrogenase deficiency is a rare mitochondrial disease leading to energy deficiency in the cells. This particularly affects the central nervous system, resulting in a broad range of neurological symptoms.
- Published
- 2019
4. Microbiota-gut brain axis involvement in neuropsychiatric disorders
- Author
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Hervé M. Blottière, Emilio Russo, Sigrid Pedersen, Francesca Ronchi, Luigi Francesco Iannone, Gaia Luongo, Federico Zara, Cinzia Ferraris, P. Mainardi, Anna Tagliabue, Alberto Preda, Gerard Clarke, Kaja Kristine Selmer, Elisa Santocchi, Stefania Provasi, Vincenzo Belcastro, Carmen Giordano, Alberto Verrotti, Pietro Baldelli, Carlo Minetti, Rita Citraro, Diego Albani, Pasquale Striano, Andrea Petretto, Paola Iannetti, Marco Carotenuto, Jakob Zimmermann, Nicola Segata, Annamaria Cattaneo, Alberto Spalice, Letizia Guiducci, Sanjay M. Sisodiya, Iannone, Luigi Francesco, Preda, Alberto, Blottière, Hervé M, Clarke, Gerard, Albani, Diego, Belcastro, Vincenzo, Carotenuto, Marco, Cattaneo, Annamaria, Citraro, Rita, Ferraris, Cinzia, Ronchi, Francesca, Luongo, Gaia, Santocchi, Elisa, Guiducci, Letizia, Baldelli, Pietro, Iannetti, Paola, Pedersen, Sigrid, Petretto, Andrea, Provasi, Stefania, Selmer, Kaja, Spalice, Alberto, Tagliabue, Anna, Verrotti, Alberto, Segata, Nicola, Zimmermann, Jakob, Minetti, Carlo, Mainardi, Paolo, Giordano, Carmen, Sisodiya, Sanjay, Zara, Federico, Russo, Emilio, Striano, Pasquale, University of Catanzaro, University of Genoa (UNIGE), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, University College Cork (UCC), IRCCS - Istituto di Ricerche Farmacologiche 'Mario Negri', Saint Anna Hospital, Partenaires INRAE, Università degli studi della Campania 'Luigi Vanvitelli', King's College, University of Pavia, University of Bern, Ordine dei Tecnologi Alimentari Campania e Lazio, Stella Maris Foundation, Institute of Clinical Physiology, National Council of Research, University of Genova, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Oslo University Hospital [Oslo], Istituto Giannina Gaslini, University of Laquila, University of Trento, Kolfarma SRL, Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta' (CMIC), Politecnico di Milano [Milan] (POLIMI), Department of Clinical and Experimental Epilepsy, and UCL Institute of Neurology
- Subjects
microbiota-gut brain axis ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,Central nervous system ,Gut–brain axis ,Inflammation ,Bidirectional communication ,digestive system ,03 medical and health sciences ,fluids and secretions ,0302 clinical medicine ,Ketogenic diet ,inflammation ,manipulating microbiota ,metabolomics ,neuropsychiatric disorders ,Central Nervous System Diseases ,medicine ,microbiota-gut brain axi ,Humans ,Pharmacology (medical) ,Ketogenic diet, inflammation, manipulating microbiota, metabolomics, microbiota-gut brain axis, neuropsychiatric disorders ,business.industry ,General Neuroscience ,Multiple sclerosis ,Mental Disorders ,medicine.disease ,3. Good health ,030227 psychiatry ,Clinical neurology ,Gastrointestinal Microbiome ,stomatognathic diseases ,medicine.anatomical_structure ,Clinical evidence ,Immunology ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery ,metabolomic - Abstract
International audience; Introduction: The microbiota-gut brain (MGB) axis is the bidirectional communication between the intestinal microbiota and the brain. An increasing body of preclinical and clinical evidence has revealed that the gut microbial ecosystem can affect neuropsychiatric health. However, there is still a need of further studies to elucidate the complex gene-environment interactions and the role of the MGB axis in neuropsychiatric diseases, with the aim of identifying biomarkers and new therapeutic targets, to allow early diagnosis and improving treatments. Areas covered: To review the role of MGB axis in neuropsychiatric disorders, prediction and prevention of disease through exploitation, integration, and combination of data from existing gut microbiome/microbiota projects and appropriate other International '-Omics' studies. The authors also evaluated the new technological advances to investigate and modulate, through nutritional and other interventions, the gut microbiota. Expert opinion: The clinical studies have documented an association between alterations in gut microbiota composition and/or function, whereas the preclinical studies support a role for the gut microbiota in impacting behaviors which are of relevance to psychiatry and other central nervous system (CNS) disorders. Targeting MGB axis could be an additional approach for treating CNS disorders and all conditions in which alterations of the gut microbiota are involved.
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- 2019
5. Pyruvatdehydrogenase-mangel
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Kaja Kristine Selmer, Anette Ramm-Pettersen, Sigrid Pedersen, and Yngve Thomas Bliksrud
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medicine.medical_specialty ,medicine.anatomical_structure ,Endocrinology ,Internal medicine ,Mitochondrial disease ,Central nervous system ,medicine ,General Medicine ,Biology ,medicine.disease ,Energy deficiency ,Pyruvate dehydrogenase deficiency - Abstract
Pyruvate dehydrogenase deficiency is a rare mitochondrial disease leading to energy deficiency in the cells. This particularly affects the central nervous system, resulting in a broad range of neurological symptoms.
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- 2019
6. Coffee inhibits nuclear factor-kappa B in prostate cancer cells and xenografts
- Author
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Harald Carlsen, Ingvild Paur, Siv Kjølsrud Bøhn, Heidi Kiil Blomhoff, Marit Kolberg, Sigrid Pedersen, Kristine Lillebø Holm, Maiko Mitake, and Rune Blomhoff
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Male ,0301 basic medicine ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Apoptosis ,urologic and male genital diseases ,Coffee ,Biochemistry ,Mice ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,In vivo ,Cell Line, Tumor ,Gene expression ,medicine ,Animals ,Humans ,Molecular Biology ,Transcription factor ,Caspase ,Cell Proliferation ,Tumor microenvironment ,Nutrition and Dietetics ,biology ,NF-kappa B ,Prostatic Neoplasms ,medicine.disease ,Molecular biology ,Cytoprotection ,030104 developmental biology ,030220 oncology & carcinogenesis ,biology.protein ,Heterografts - Abstract
Chronic inflammation contributes to prostate cancer and the transcription factor Nuclear Factor-kappa B (NF-κB) is constitutively active in most such cancers. We examine the effects of coffee on NF-κB and on the regulation of selected genes in human-derived prostate cancer cells (PC3) and in PC3 xenografts in athymic nude mice. PC3 cells stably transduced with an NF-κB-luciferase reporter were used both in vitro and for xenografts. NF-κB activity was measured by reporter assays, DNA binding and in vivo imaging. Gene expression was measured in PC3 cells, xenografts and tumor microenvironment by low-density arrays. Western blotting of activated caspases was used to quantify apoptosis. Coffee inhibited TNFα-induced NF-κB activity and DNA-binding in PC3 cells. Furthermore, coffee increased apoptosis and modulated expression of a number of inflammation- and cancer-related genes in TNFα-treated PC3 cells. In vivo imaging revealed a 31% lower NF-κB-luciferase activation in the xenografts of the mice receiving 5% coffee compared to control mice. Interestingly, we observed major changes in gene expression in the PC3 cells in xenografts as compared to PC3 cells in vitro. In PC3 xenografts, genes related to inflammation, apoptosis and cytoprotection were down-regulated in mice receiving coffee, and coffee also affected the gene expression in the xenograft microenvironment. Our data demonstrate that coffee inhibits NF-κB activity in PC3 cells in vitro and in xenografts. Furthermore, coffee modulates transcription of genes related to prostate cancer and inflammation. Our results are the first to suggest mechanistic links between coffee consumption and prostate cancer in an experimental mouse model.
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- 2016
7. Dietary therapy for epilepsy
- Author
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Magnhild, Kverneland, Ellen, Molteberg, Kathrine C, Haavardsholm, Sigrid, Pedersen, Anette, Ramm-Pettersen, and Karl O, Nakken
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Adult ,Diet, Carbohydrate-Restricted ,Drug Resistant Epilepsy ,Motivation ,Seizures ,Humans ,Patient Compliance ,Child ,Diet, Ketogenic - Abstract
Children with pharmacoresistant epilepsy should be offered ketogenic dietary therapy. The diet, which is rich in fat and low in carbohydrate, has a beneficial effect in reducing seizures in this patient group. It may also have a beneficial effect in adults, but there is less evidence than in children. Dietary treatment of epilepsy is a specialist therapy, and in order to adhere to the diet, strong motivation of the patient and relatives as well as close follow-up from the specialist health service are necessary.
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- 2017
8. Diettbehandling av epilepsi
- Author
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Sigrid Pedersen, Ellen Molteberg, Anette Ramm-Pettersen, Karl O. Nakken, Magnhild Kverneland, and Kathrine C. Haavardsholm
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Pediatrics ,medicine.medical_specialty ,business.industry ,General Medicine ,medicine.disease ,Pharmacoresistant epilepsy ,Epilepsy ,Health services ,Dietary treatment ,medicine ,Dietary therapy ,Patient group ,business ,Patient compliance - Abstract
Children with pharmacoresistant epilepsy should be offered ketogenic dietary therapy. The diet, which is rich in fat and low in carbohydrate, has a beneficial effect in reducing seizures in this patient group. It may also have a beneficial effect in adults, but there is less evidence than in children. Dietary treatment of epilepsy is a specialist therapy, and in order to adhere to the diet, strong motivation of the patient and relatives as well as close follow-up from the specialist health service are necessary.
- Published
- 2017
9. Tomato paste alters NF-κB and cancer-related mRNA expression in prostate cancer cells, xenografts, and xenograft microenvironment
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Marit Kolberg, Harald Carlsen, Rune Blomhoff, Nasser E. Bastani, Sigrid Pedersen, and Ingvild Paur
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Male ,STAT3 Transcription Factor ,Cancer Research ,Medicine (miscellaneous) ,Gene Expression ,Mice, Nude ,Prostate cancer ,Mice ,Lycopene ,Solanum lycopersicum ,Cell Line, Tumor ,Gene expression ,medicine ,Tumor Microenvironment ,Animals ,Humans ,RNA, Messenger ,STAT3 ,Tumor microenvironment ,Nutrition and Dietetics ,biology ,Plant Extracts ,Tumor Necrosis Factor-alpha ,Gene Expression Profiling ,fungi ,NF-kappa B ,food and beverages ,Cancer ,Prostatic Neoplasms ,medicine.disease ,Carotenoids ,Oncology ,Apoptosis ,Cell culture ,Immunology ,Cancer research ,biology.protein ,Heterografts ,Tumor necrosis factor alpha ,STAT6 Transcription Factor ,Oxidation-Reduction ,Signal Transduction - Abstract
Tomatoes may protect against prostate cancer development, possibly through targeting signaling pathways such as nuclear factor-κB (NF-κB). We investigated whether tomato paste could modulate NF-κB activity and cancer-related gene expression in human derived prostate cancer cells (PC3) and PC3 xenografts. PC3-cells were stably transduced with an NF-κB-luciferase construct, and treated with tomato extracts or vehicle control. Nude mice bearing PC3 xenografts were fed a Western-like diet with or without 10% tomato paste for 6.5 wk. The tomato diet significantly inhibited TNFα stimulated NF-κB activity in cultured PC3 cells, and modulated the expression of genes associated with inflammation, apoptosis, and cancer progression. Accumulation of lycopene occurred in liver, xenografts, and serum of mice fed tomato diet. Tomato paste in the diet did not affect tumor size in mice; however, there was a trend toward inhibition of NF-κB activity in the xenografts. The effect of tomato on gene expression was most prominent in the xenograft microenvironment, where among others NFKB2, STAT3, and STAT6 showed higher expression levels after tomato treatment. Our findings support biological activity of tomatoes in cancer-related inflammation.
- Published
- 2015
10. Plant extracts of spices and coffee synergistically dampen nuclear factor-κB in U937 cells
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Marit Kolberg, Rune Blomhoff, Trude Rakel Balstad, David R. Jacobs, Ingvild Paur, and Sigrid Pedersen
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Lipopolysaccharides ,Lipopolysaccharide ,Endocrinology, Diabetes and Metabolism ,Large array ,Phytochemicals ,Anti-Inflammatory Agents ,Coffea ,Nuclear factor κb ,Biology ,Pharmacology ,Monocytes ,Thymus Plant ,chemistry.chemical_compound ,Endocrinology ,Origanum ,Humans ,Spices ,Transcription factor ,Nutrition and Dietetics ,U937 cell ,Dose-Response Relationship, Drug ,business.industry ,Plant Extracts ,NF-kappa B ,NF-κB ,Drug Synergism ,U937 Cells ,Biotechnology ,chemistry ,Cell culture ,business ,Antagonism - Abstract
A large array of bioactive plant compounds (phytochemicals) has been identified and synergy among these compounds might contribute to the beneficial effects of plant foods. The transcription factor nuclear factor-κB (NF-κB) has been suggested as a target for many phytochemicals. Due to the complexity of mechanisms involved in NF-κB regulation, including numerous feedback loops, and the large number of phytochemicals which regulate NF-κB activity, we hypothesize that synergistic or antagonistic effects are involved. The objectives of our study were to develop a statistical methodology to evaluate the concept of synergy and antagonism and to use this methodology in a monocytic cell line (U937 expressing an NF-κB-luciferase reporter) treated with lipopolysaccharide and phytochemical-rich plant extracts. Both synergistic and antagonistic effects were clearly observed. Observed synergy was most pronounced for the combinations of oregano and coffee, and thyme and oregano. For oregano and coffee the synergistic effect was highest at 5 mg/mL with 13.9% (P < .001), and for thyme and oregano the highest synergistic effects was at 3 mg/mL with 13.7% (P < .001). Dose dependent synergistic and antagonistic effects were observed for all combinations tested. In conclusion, this work presents a methodological tool to define synergy in experimental studies. Our results support the hypothesis that phytochemical-rich plants may exert synergistic and antagonistic effects on NF-κB regulation. Such complex mechanistic interactions between phytochemicals are likely to underlie the protective effects of a plant-based diet on life-style related diseases.
- Published
- 2013
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