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1. Effect of specialised versus generalised outpatient treatment for bipolar disorder: the CAG Bipolar trial - study protocol for a randomised controlled trial

Author

Maria Faurholt-Jepsen, Ida Hageman, Maj Vinberg, Lars Vedel Kessing, Ellen Margrethe Christensen, Natacha Blauenfeldt Kyster, Pernille Bondo-Kozuch, Birgitte Vejstrup, Birte Smidt, Anne-Marie Bangsgaard Jørgensen, Raben Rosenberg, Darius Mardosas, Louise Behrend Rasmussen, Kim Brøndmark, Signe Seidelin, Ida Palmblad Sarauw-Nielsen, and Annemette Larsen

Subjects
Medicine
Abstract

Introduction Despite current available treatment patients with bipolar disorder often experience relapses and decreased overall functioning. Furthermore, patients with bipolar disorder are often not treated medically or psychologically according to guidelines and recommendations. A Clinical Academic Group is a new treatment initiative bringing together clinical services, research, education and training to offer care and treatment that is based on reliable evidence backed up by research. The present Clinical Academic Group for bipolar disorder (the CAG Bipolar) randomised controlled trial (RCT) aims for the first time to investigate whether specialised outpatient treatment in CAG Bipolar versus generalised community-based treatment improves patient outcomes and clinician’s satisfaction with care in patients with bipolar disorder.Methods and analysis The CAG Bipolar trial is a pragmatic randomised controlled parallel-group trial undertaken in the Capital Region of Denmark covering a catchment area of 1.85 million people. Patients with bipolar disorder are invited to participate as part of their outpatient treatment in the Mental Health Services. The included patients will be randomised to (1) specialised outpatient treatment in the CAG Bipolar (intervention group) or (2) generalised community-based outpatient treatment (control group). The trial started 13 January 2020 and has currently included more than 600 patients. The outcomes are (1) psychiatric hospitalisations and cumulated number and duration of psychiatric hospitalisations (primary), and (2) self-rated depressive symptoms, self-rated manic symptoms, quality of life, perceived stress, satisfaction with care, use of medication and the clinicians’ satisfaction with their care (secondary). A total of 1000 patients with bipolar disorder will be included.Ethics and dissemination The CAG Bipolar RCT is funded by the Capital Region of Denmark and ethical approval has been obtained from the Regional Ethical Committee in The Capital Region of Denmark (H-19067248). Results will be published in peer-reviewed academic journals, presented at scientific meetings and disseminated to patient organisations and media outlets.Trial registration number NCT04229875.

Published
2021
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2. From atomic fountains to ultra-stable lasers

Author

Bess Fang, Herve Le Goff, Baptiste Chupin, Luca Lorini, Michel Abgrall, Pascal Blondé, Daniele Rovera, Philip Tuckey, Pierre Uhrich, Joseph Achkar, Jocelyne Guéna, Nicolas Galland, Shuo Zhang, Nemanja Lucic, Rodolphe Le Targat, Signe Seidelin, Alban Ferrier, Philippe Goldner, Yann Le Coq, Sébastien Bize, Laboratoire national de métrologie et d'essais - Systèmes de Référence Temps-Espace (LNE - SYRTE), Systèmes de Référence Temps Espace (SYRTE), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Nano-Optique et Forces (NEEL - NOF), Institut Néel (NEEL), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Institut de Recherche de Chimie Paris (IRCP), Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC), Région Ile de France DIM C’nano and SIRTEQ, LABEX Cluster of Excellence FIRST-TF (ANR-10-LABX-48-01) within the Program 'Investissement d’Avenir' operated by the French National Research Agency (ANR), European Project: 712721,NanOQTech, European Project: OC18, and Henry, Florence

Subjects
[PHYS]Physics [physics], Optical frequency metrology, Ultrastable lasers, [PHYS.ASTR] Physics [physics]/Astrophysics [astro-ph], Spectral hole burning
Abstract

The SI second is currently defined through the ground-state hyperfine transition frequency of the cesium atom. We discuss the calibration of international time scales using one of the primary frequency standards at LNE-SYRTE. However, the future of time and frequency metrology lies in the optical domain. We describe our ongoing research on laser spectroscopy for ultra-stable lasers which will eventually enable the ultimate performance in optical clocks.

Published
2021

3. Effect of specialised versus generalised outpatient treatment for bipolar disorder:The CAG Bipolar trial-study protocol for a randomised controlled trial

Author

Maria Faurholt-Jepsen, Ida Hageman, Maj Vinberg, Lars Vedel Kessing, Ellen Margrethe Christensen, Natacha Blauenfeldt Kyster, Pernille Bondo-Kozuch, Birgitte Vejstrup, Birte Smidt, Anne-Marie Bangsgaard Jørgensen, Raben Rosenberg, Darius Mardosas, Louise Behrend Rasmussen, Kim Brøndmark, Signe Seidelin, Ida Palmblad Sarauw-Nielsen, and Annemette Larsen

Subjects
medicine.medical_specialty, Bipolar Disorder, Adult psychiatry, Capital region, organisation of health services, law.invention, Quality of life (healthcare), Randomized controlled trial, law, Outpatients, mental disorders, Ambulatory Care, Medicine, Humans, In patient, Bipolar disorder, Randomized Controlled Trials as Topic, Protocol (science), business.industry, Trial study, General Medicine, medicine.disease, Mental health, Mental Health, Research Design, Depression & mood disorders, Organisation of health services, depression & mood disorders, Physical therapy, adult psychiatry, Neoplasm Recurrence, Local, business
Abstract

IntroductionDespite current available treatment patients with bipolar disorder often experience relapses and decreased overall functioning. Furthermore, patients with bipolar disorder are often not treated medically or psychologically according to guidelines and recommendations. A Clinical Academic Group is a new treatment initiative bringing together clinical services, research, education and training to offer care and treatment that is based on reliable evidence backed up by research. The present Clinical Academic Group for bipolar disorder (the CAG Bipolar) randomised controlled trial (RCT) aims for the first time to investigate whether specialised outpatient treatment in CAG Bipolar versus generalised community-based treatment improves patient outcomes and clinician’s satisfaction with care in patients with bipolar disorder.Methods and analysisThe CAG Bipolar trial is a pragmatic randomised controlled parallel-group trial undertaken in the Capital Region of Denmark covering a catchment area of 1.85 million people. Patients with bipolar disorder are invited to participate as part of their outpatient treatment in the Mental Health Services. The included patients will be randomised to (1) specialised outpatient treatment in the CAG Bipolar (intervention group) or (2) generalised community-based outpatient treatment (control group). The trial started 13 January 2020 and has currently included more than 600 patients. The outcomes are (1) psychiatric hospitalisations and cumulated number and duration of psychiatric hospitalisations (primary), and (2) self-rated depressive symptoms, self-rated manic symptoms, quality of life, perceived stress, satisfaction with care, use of medication and the clinicians’ satisfaction with their care (secondary). A total of 1000 patients with bipolar disorder will be included.Ethics and disseminationThe CAG Bipolar RCT is funded by the Capital Region of Denmark and ethical approval has been obtained from the Regional Ethical Committee in The Capital Region of Denmark (H-19067248). Results will be published in peer-reviewed academic journals, presented at scientific meetings and disseminated to patient organisations and media outlets.Trial registration numberNCT04229875.

Published
2021

4. A single nitrogen-vacancy defect coupled to a nanomechanical oscillator

Author

O. Arcizet, Philippe Poncharal, Alessandro Siria, Signe Seidelin, Pascal Vincent, and Vincent Jacques

Subjects
Physics, Quantum optics, Cantilever, Condensed matter physics, Nanowire, Physics::Optics, General Physics and Astronomy, Diamond, engineering.material, 01 natural sciences, Inductive coupling, 010305 fluids & plasmas, Condensed Matter::Materials Science, Vacancy defect, 0103 physical sciences, Physics::Atomic and Molecular Clusters, engineering, Quantum system, 010306 general physics, Spin (physics)
Abstract

A single quantum system comprising a nitrogen-vacancy in diamond is now coupled to a nanowire cantilever. Magnetic fields can then couple the nitrogen-vacancy spin and the oscillator enabling read-out of the nanometre-scale motion.

Published
2011

5. Les émulateurs pédagogiques: une source d’innovations qui se construit à l’Université Joseph Fourier de Grenoble

Author

Christian Hoffmann, Anne Briançon-Marjollet, Philippe Brulard, Jean-Luc Cracowski, Julien Douady, Myriam Houssay-Holzschuch, pascal lafourcade, Isabelle Le Brun, Signe Seidelin, Sophie Térouanne, Hélium : du fondamental aux applications (HELFA), Institut Néel (NEEL), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS), Education, Cultures et Politiques (ECP), Université Lumière - Lyon 2 (UL2)-Université Jean Monnet [Saint-Étienne] (UJM), Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire (HP2), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Joseph Fourier - Grenoble 1 (UJF), Laboratoire Interdisciplinaire de Physique [Saint Martin d’Hères] (LIPhy), Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Pacte, Laboratoire de sciences sociales (PACTE), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Sciences Po Grenoble - Institut d'études politiques de Grenoble (IEPG)-Centre National de la Recherche Scientifique (CNRS), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Grenoble Institut des Neurosciences (GIN), and Nano-Optique et Forces (NOF)

Subjects
valeurs, accompagnement, Enseignants, [SHS.EDU]Humanities and Social Sciences/Education, identité, innovation
Abstract

International audience; Nous décrivons et analysons dans cette communication le fonctionnement d’un groupe d’enseignants et d’enseignants-chercheurs qui contribue au développement professionnel de chacun de ses membres d’une part, et qui devient une source durable d’innovations pédagogiques dans notre établissement d’autre part.

Published
2015

6. Experimental study of coupling Bose–Einstein condensates into weakly non-trapping and trapping states

Author

G. Delannoy, Fabrice Gerbier, Alain Aspect, Signe Seidelin, Joseph H. Thywissen, S. Richard, Philippe Bouyer, Sadiqali A. Rangwala, and Y. Le Coq

Subjects
Condensed Matter::Quantum Gases, Physics, Oscillation, General Physics and Astronomy, Trapping, Instability, law.invention, Atom laser, Coupling (physics), Frequency comb, law, Ultracold atom, Physics::Atomic Physics, Atomic physics, Bose–Einstein condensate
Abstract

We study the production of an atom laser from a Bose–Einstein condensate using radio-frequency out-coupling. Single frequency coupling from the Bose–Einstein condensate leads to unstable production of an atom laser due to the extreme sensitivity of this process to magnetic field fluctuations. The extent of this experimental instability is quantified. Stable, repeatable production of an atom laser is achieved by the frequency modulation of the coupling, which forms a frequency comb across the condensate. Different regimes of modulated coupling are discussed. In addition the coupling of atoms into a weakly trapping state is studied. The oscillation frequency of this state in the vertical direction is measured. Preliminary results indicating qualitative difference between condensate and thermal cloud coupling are presented.

Published
2001

7. Surface effects in a semiconductor photonic nanowire and spectral stability of an embedded single quantum dot

Author

Jean-Philippe Poizat, Emmanuel Dupuy, Édouard Wagner, Yann-Michel Niquet, N. S. Malik, Joël Bleuse, Mathieu Munsch, Gilles Nogues, Signe Seidelin, Inah Yeo, Julien Claudon, Jean-Michel Gérard, Alexia Auffèves, Nanophysique et Semiconducteurs (NPSC), Institut Néel (NEEL), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Institut Nanosciences et Cryogénie (INAC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Automatisation et Caractérisation (AUTOCARAC), Nano-Optique et Forces (NOF), Nanophysique et Semiconducteurs (NEEL - NPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS), Automatisation & caractérisation (NEEL - AUTOCARAC), and Nano-Optique et Forces (NEEL - NOF)

Subjects
Photon, Materials science, III-V semiconductors, Physics and Astronomy (miscellaneous), Nanowire, Physics::Optics, FOS: Physical sciences, 02 engineering and technology, 01 natural sciences, semiconductor quantum dots, [PHYS.QPHY]Physics [physics]/Quantum Physics [quant-ph], 0103 physical sciences, Mesoscale and Nanoscale Physics (cond-mat.mes-hall), Laser power scaling, 010306 general physics, Quantum optics, Quantum Physics, Condensed Matter - Mesoscale and Nanoscale Physics, business.industry, 021001 nanoscience & nanotechnology, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, gallium arsenide, indium compounds, Semiconductor, surface charging, nanowires, Quantum dot, [PHYS.COND.CM-GEN]Physics [physics]/Condensed Matter [cond-mat]/Other [cond-mat.other], Optoelectronics, Photonics, 0210 nano-technology, business, 78.67.Hc, 78.67.Uh, 73.40.-c, Quantum Physics (quant-ph), Excitation
Abstract

International audience; We evidence the influence of surface effects for InAs quantum dots embedded into GaAs photonic nanowires used as efficient single photon sources. We observe a continuous temporal drift of the emission energy that is an obstacle to resonant quantum optics experiments at the single photon level. We attribute the drift to the sticking of oxygen molecules onto the wire, which modifies the surface charge and hence the electric field seen by the quantum dot. The influence of temperature and excitation laser power on this phenomenon is studied. Most importantly, we demonstrate a proper treatment of the nanowire surface to suppress the drift.

Published
2011
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8. Continuous-wave versus time-resolved measurements of Purcell-factors for quantum dots in semiconductor microcavities

Author

Alexia Auffèves, Alexis Mosset, Signe Seidelin, Isabelle Sagnes, Mathieu Munsch, Jean-Philippe Poizat, Jean-Michel Gérard, Pascale Senellart, Aristide Lemaître, Nanophysique et Semiconducteurs (NPSC), Institut Néel (NEEL), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS), Nano-Optique et Forces (NOF), Laboratoire de photonique et de nanostructures (LPN), Centre National de la Recherche Scientifique (CNRS), and QAP, Contract No. 15848

Subjects
FOS: Physical sciences, Physics::Optics, 02 engineering and technology, Purcell effect, Purcell factor, 01 natural sciences, law.invention, law, 0103 physical sciences, Mesoscale and Nanoscale Physics (cond-mat.mes-hall), 010306 general physics, [PHYS.COND.CM-MSQHE]Physics [physics]/Condensed Matter [cond-mat]/Mesoscopic Systems and Quantum Hall Effect [cond-mat.mes-hall], Physics, 42.50.Pq, 78.67.Hc, 78.90.+t, Condensed matter physics, Condensed Matter - Mesoscale and Nanoscale Physics, business.industry, photo luminescence, Cavity quantum electrodynamics, Resonance, quantum dot, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Optical microcavity, [PHYS.PHYS.PHYS-GEN-PH]Physics [physics]/Physics [physics]/General Physics [physics.gen-ph], Electronic, Optical and Magnetic Materials, Semiconductor, Quantum dot, Quantum dot laser, Continuous wave, Optoelectronics, Physics::Accelerator Physics, 0210 nano-technology, business, micropillar cavity
Abstract

International audience; The light emission rate of a single quantum dot can be drastically enhanced by embedding it in a resonant semiconductor microcavity. This phenomenon is known as the Purcell effect, and the coupling strength between emitter and cavity can be quantified by the Purcell factor. The most natural way for probing the Purcell effect is a time-resolved measurement. However, this approach is not always the most convenient one, and alternative approaches based on a continuous-wave measurement are often more appropriate. Various signatures of the Purcell effect can indeed be observed using continuous-wave measurements (increase of the pump rate needed to saturate the quantum dot emission, enhancement of its emission rate at saturation, change of its radiation pattern), signatures which are encountered when a quantum dot is put on-resonance with the cavity mode. All these observations potentially allow one to estimate the Purcell factor. In this paper, we carry out these different types of measurements for a single quantum dot in a pillar microcavity and we compare their reliability. We include in the data analysis the presence of independent, non-resonant emitters in the microcavity environment, which are responsible for a part of the observed fluorescence.

Published
2009

9. Rapid cooling of a strain-coupled oscillator by an optical phase-shift measurement

Author

Yann Le Coq, Signe Seidelin, Klaus Mølmer, Nano-Optique et Forces (NOF ), Institut Néel (NEEL), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Laboratoire national de métrologie et d'essais - Systèmes de Référence Temps-Espace (LNE - SYRTE), Systèmes de Référence Temps Espace (SYRTE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Aarhus University [Aarhus], and European Union’s Horizon 2020 research and innovation program under grant agreement No 712721 (NanOQTech)-LABEX Cluster of Excellence FIRST-TF (ANR-10-LABX-48-01), within the Program 'Investissements d’Avenir' operated by the French National Research Agency (ANR)-Villum Foundation-Ville de Paris Emergence Program

Subjects
Physics, Quantum Physics, [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], Cantilever, Doping, FOS: Physical sciences, Thermal fluctuations, Optical field, 01 natural sciences, Computer Science::Digital Libraries, 010305 fluids & plasmas, Ion, Resonator, [PHYS.QPHY]Physics [physics]/Quantum Physics [quant-ph], 0103 physical sciences, Active cooling, Spectral hole burning, Physics::Atomic Physics, Atomic physics, Quantum Physics (quant-ph), 010306 general physics, Computer Science::Formal Languages and Automata Theory, Optics (physics.optics), Physics - Optics
Abstract

International audience; We consider an optical probe that interacts with an ensemble of rare earth ions doping a materialin the shape of a cantilever. By optical spectral hole burning, the inhomogeneously broadenedtransition in the ions is prepared to transmit the probe field within a narrow window, but bendingof the cantilever causes strain in the material which shifts the ion resonances. The motion of thecantilever may thus be registered by the phase shift of the probe. By continuously measuringthe optical field we induce a rapid reduction of the position and momentum uncertainty of thecantilever. Doing so, the probing extracts entropy and thus effectively cools the thermal state ofmotion towards a known, conditional oscillatory motion with strongly reduced thermal fluctuations.Moreover, as the optical probe provides a force on the resonator proportional to its intensity, it ispossible to exploit the phase shift measurements in order to create an active feedback loop, whicheliminates the thermal fluctuations of the resonator. We describe this system theoretically, andprovide numerical simulations which demonstrate the rapid reduction in resonator position andmomentum uncertainty, as well as the implementation of the active cooling protocol.

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