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16 results on '"Siewe Fodjo, Joseph N."'

2. Onchocerciasis-associated epilepsy: an explorative case-control study with viral metagenomic analyses on Onchocerca volvulus

Author

Hadermann, Amber, primary, Jada, Stephen Raimon, additional, Sebit, Wilson J., additional, Deng, Thomas, additional, Bol, Yak Y., additional, Siewe Fodjo, Joseph N., additional, De Coninck, Lander, additional, Matthijnssens, Jelle, additional, Mertens, Inge, additional, Polman, Katja, additional, and Colebunders, Robert, additional

Published
2023
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4. Assessing Onchocerca volvulus Intensity of Infection and Genetic Diversity Using Mitochondrial Genome Sequencing of Single Microfilariae Obtained before and after Ivermectin Treatment

Author

Hedtke, Shannon M., primary, Choi, Young-Jun, additional, Kode, Anusha, additional, Chalasani, Gowtam C., additional, Sirwani, Neha, additional, Jada, Stephen R., additional, Hotterbeekx, An, additional, Mandro, Michel, additional, Siewe Fodjo, Joseph N., additional, Amambo, Glory Ngongeh, additional, Abong, Raphael A., additional, Wanji, Samuel, additional, Kuesel, Annette C., additional, Colebunders, Robert, additional, Mitreva, Makedonka, additional, and Grant, Warwick N., additional

Published
2023
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5. Impact of a bi-annual community-directed treatment with ivermectin programme on the incidence of epilepsy in an onchocerciasis-endemic area of Mahenge, Tanzania: A population-based prospective study

Author

Bhwana, Dan, primary, Amaral, Luís-Jorge, additional, Mhina, Athanas, additional, Hayuma, Paul Martine, additional, Francis, Filbert, additional, Siewe Fodjo, Joseph N., additional, Mmbando, Bruno P., additional, and Colebunders, Robert, additional

Published
2023
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10. First description of Nodding Syndrome in the Central African Republic

Author

Metanmo, Salvatore, primary, Boumédiène, Farid, additional, Preux, Pierre-Marie, additional, Colebunders, Robert, additional, Siewe Fodjo, Joseph N., additional, de Smet, Eric, additional, Yangatimbi, Emmanuel, additional, Winkler, Andrea S., additional, Mbelesso, Pascal, additional, and Ajzenberg, Daniel, additional

Published
2021
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14. Focus of Ongoing Onchocerciasis Transmission Close to Bangui, Central African Republic

Author

de Smet, Eric, primary, Metanmo, Salvatore, additional, Mbelesso, Pascal, additional, Kemata, Benoit, additional, Siewe Fodjo, Joseph N., additional, Boumédiène, Farid, additional, Ekwoge, Hilda T., additional, Yangatimbi, Emmanuel, additional, Ajzenberg, Daniel, additional, Badibanga, Orphee, additional, Preux, Pierre-Marie, additional, and Colebunders, Robert, additional

Published
2020
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16. Rapid diagnostic testing for onchocerciasis in Maridi (South Sudan) before and after improving elimination strategies: a repeated cross-sectional survey.

Author

Hadermann A, Jada SR, Amaral LJ, Colebunders R, Bol YY, and Siewe Fodjo JN

Abstract

Background: Maridi County is an onchocerciasis-endemic area in South Sudan. Annual community-directed treatment with ivermectin (CDTi) was instituted in Maridi since the early 2000s, but with low coverage. In 2021, the CDTi programme was strengthened to a six-monthly programme. Additionally, the community-based vector control strategy "Slash and Clear" has been implemented since 2019 at the Maridi Dam, the only blackfly breeding site in the area. This study assessed the effect of these reinforced onchocerciasis elimination interventions on the Onchocerca volvulus seroprevalence among young children, an indicator of ongoing transmission., Methods: Baseline and follow-up serosurveys were conducted in Maridi in 2019 (prior to strengthening onchocerciasis elimination efforts) and 2023, respectively. During both surveys, children aged three to nine years were recruited from five study sites situated at different distances from the Maridi Dam. Ov16 antibodies were detected via rapid diagnostic tests (RDTs) using whole blood obtained by finger-pricking the participants. Baseline and follow-up Ov16 prevalence rates were calculated and compared., Results: In 2019, the Ov16 seroprevalence among children aged three to nine years was 24.5% compared to 30.6% in 2023 (p=0.22). Both surveys found a particularly high Ov16 seroprevalence in the study site closest to the Maridi Dam (35.0% in 2019 and 44.0% in 2023, p=0.52). The Ov16 seroprevalence had a non-significant decreasing trend in the three-year-old children, from 12.5% (3/24) in 2019 to 8.8% (3/34) in 2023 (p=0.65)., Conclusion: The persistent Ov16 RDT seropositivity among three-year-old children in 2023 indicates ongoing O. volvulus transmission. Therefore, further strengthening of the onchocerciasis elimination programme is required. The study highlights the utility of RDTs in monitoring onchocerciasis transmission in highly endemic settings., Competing Interests: No competing interests were disclosed., (Copyright: © 2024 Hadermann A et al.)

Published
2024
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