Search

This chapter discusses the evolution of an opioid use disorder as well as treatment approaches, including the medication-assisted treatments of methadone, buprenorphine, and naltrexone and non-pharmacologic interventions. Using the narrative of a case study, readers will improve their understanding on how to diagnose, assess, and treat opioid use disorder. They will also learn how to weigh the pros and cons of the existing medication treatment options and how to begin prescribing these medications to their patients. Issues covered include the role of prescription opioids and untreated pain in the development of an opioid use disorder, misconceptions and stigma about medication-assisted treatment, and the increasing use of kratom, an unscheduled opioid receptor agonist, among patients with opioid use disorder.

We report on the first results of a large-scale comparison study of central pit craters throughout the solar system, focused on Mars, Mercury, Ganymede, Rhea, Dione, and Tethys. We have identified 10 more central pit craters on Rhea, Dione, and Tethys than have previously been reported. We see a general trend that the median ratio of the pit to crater diameter (Dp/Dc) decreases with increasing gravity and decreasing volatile content of the crust. Floor pits are more common on volatile-rich bodies while summit pits become more common as crustal volatile content decreases. Uplifted bedrock from below the crater floor occurs in the central peak upon which summit pits are found and in rims around floor pits, which may or may not break the surface. Peaks on which summit pits are found on Mars and Mercury share similar characteristics to those of nonpitted central peaks, indicating that some normal central peaks undergo an additional process to create summit pits. Martian floor pits do not appear to be the result of a central peak collapse as the median ratio of the peak to crater diameter (Dpk/Dc) is about twice as high for central peaks/summit pits than Dp/Dc values for floor pits. Median Dpk/Dc is twice as high for Mars as for Mercury, reflecting differing crustal strength between the two bodies. Results indicate that a complicated interplay of crustal volatiles, target strength, surface gravity, and impactor energy along with both uplift and collapse are involved in central pit formation. Multiple formation models may be required to explain the range of central pits seen throughout the solar system.

Exoplanet discoveries since the mid-1990's have revealed an astounding diversity of planetary systems. Studying these systems is essential to understanding planetary formation processes, as well as the development of life in the universe. Unfortunately, humanity can only observe limited aspects of exoplanetary systems by telescope, and the significant distances between stars presents a barrier to in situ exploration. In this study, we propose an alternative path to gain insight into exoplanetary systems: Bridge, a mission concept design to fly by an interstellar object as it passes through our solar system. Designed as a New Frontiers-class mission during the National Aeronautics and Space Administration (NASA) Planetary Science Summer Seminar, Bridge would provide a unique opportunity to gain insight into potential physical, chemical, and biological differences between solar systems as well as the possible exchange of planetary materials between them. Bridge employs ultraviolet/visible, near-infrared, and mid-infrared point spectrometers, a visible camera, and a guided impactor. We also provide a quantitative Monte Carlo analysis that estimates wait times for a suitable target, and examines key trades between ground storage and a parking orbit, power sources, inner versus outer solar system encounters, and launch criteria. Due to the fleeting nature of interstellar objects, reaching an interstellar object may require an extended ground storage phase for the spacecraft until a suitable target is discovered, followed by a rapid response launch strategy. To enable rapid response missions designed to intercept such unique targets, language would need to be added to future NASA announcements of opportunity such that ground storage and rapid response would be allowable components of a proposed mission.