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1. Empiric antibiotic regimens in adults with non-ventilator-associated hospital-acquired pneumonia: a systematic review and network meta-analysis of randomized controlled trials

Author

Ghadimi, Maryam, Siemieniuk, Reed A.C., Guyatt, Gordon, Loeb, Mark, Hazzan, Afeez Abiola, Aminaei, Danial, Gomaa, Huda, Wang, Ying, Yao, Liang, Agarwal, Arnav, Basmaji, John, Grant, Alexandre, Kim, William S.H., Alvarado-Gamarra, Giancarlo, Likhvantsev, Valery, Lima, João Pedro, Motaghi, Shahrzad, Couban, Rachel, Sadeghirad, Behnam, and Brignardello-Petersen, Romina

Published
2024
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3. Pharmacological agents for procedural sedation and analgesia in the emergency department and intensive care unit: a systematic review and network meta-analysis of randomised trials

Author

Sharif, Sameer, Kang, Jasmine, Sadeghirad, Behnam, Rizvi, Fayyaz, Forestell, Ben, Greer, Alisha, Hewitt, Mark, Fernando, Shannon M., Mehta, Sangeeta, Eltorki, Mohamed, Siemieniuk, Reed, Duffett, Mark, Bhatt, Maala, Burry, Lisa, Perry, Jeffrey J., Petrosoniak, Andrew, Pandharipande, Pratik, Welsford, Michelle, and Rochwerg, Bram

Published
2024
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4. Compelling evidence from meta-epidemiological studies demonstrates overestimation of effects in randomized trials that fail to optimize randomization and blind patients and outcome assessors

Author

Wang, Ying, Parpia, Sameer, Couban, Rachel, Wang, Qi, Armijo-Olivo, Susan, Bassler, Dirk, Briel, Matthias, Brignardello-Petersen, Romina, Gluud, Lise Lotte, Keitz, Sheri A., Letelier, Luz M., Ravaud, Philippe, Schulz, Kenneth F., Siemieniuk, Reed A.C., Zeraatkar, Dena, and Guyatt, Gordon H.

Published
2024
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7. Instruments assessing risk of bias of randomized trials frequently included items that are not addressing risk of bias issues

Author

Wang, Ying, Ghadimi, Maryam, Wang, Qi, Hou, Liangying, Zeraatkar, Dena, Iqbal, Atiya, Ho, Cameron, Yao, Liang, Hu, Malini, Ye, Zhikang, Couban, Rachel, Armijo-Olivo, Susan, Bassler, Dirk, Briel, Matthias, Gluud, Lise Lotte, Glasziou, Paul, Jackson, Rod, Keitz, Sheri A., Letelier, Luz M., Ravaud, Philippe, Schulz, Kenneth F., Siemieniuk, Reed A.C., Brignardello-Petersen, Romina, and Guyatt, Gordon H.

Published
2022
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8. Serious reporting deficiencies exist in minimal important difference studies: current state and suggestions for improvement

Author

Carrasco-Labra, Alonso, Devji, Tahira, Qasim, Anila, Phillips, Mark, Johnston, Bradley C., Devasenapathy, Niveditha, Zeraatkar, Dena, Bhatt, Meha, Jin, Xuejing, Brignardello-Petersen, Romina, Urquhart, Olivia, Foroutan, Farid, Schandelmaier, Stefan, Pardo-Hernandez, Hector, Vernooij, Robin WM., Huang, Hsiaomin, Rizwan, Yamna, Siemieniuk, Reed, Lytvyn, Lyubov, Patrick, Donald L., Ebrahim, Shanil, Furukawa, Toshi A., Nesrallah, Gihad, Schunemann, Holger J., Bhandari, Mohit, Thabane, Lehana, and Guyatt, Gordon H.

Published
2022
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11. Clinical trials in COVID-19 management & prevention: A meta-epidemiological study examining methodological quality

Author

Honarmand, Kimia, Penn, Jeremy, Agarwal, Arnav, Siemieniuk, Reed, Brignardello-Petersen, Romina, Bartoszko, Jessica J., Zeraatkar, Dena, Agoritsas, Thomas, Burns, Karen, Fernando, Shannon M., Foroutan, Farid, Ge, Long, Lamontagne, Francois, Jimenez-Mora, Mario A., Murthy, Srinivas, Yepes-Nuñez, Juan Jose, Vandvik, Per O., Ye, Zhikang, and Rochwerg, Bram

Published
2021
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12. A living WHO guideline on drugs for covid-19

Author

Siemieniuk, Reed, Rochwerg, Bram, Agoritsas, Thomas, Lamontagne, François, Leo, Yee-Sin, Macdonald, Helen, Agarwal, Arnav, Zeng, Linan, Lytvyn, Lyubov, Appiah, John Adabie, Amin, Wagdy, Arabi, Yaseen, Blumberg, Lucille, Burhan, Erlina, Bausch, Frederique Jacquerioz, Calfee, Carolyn S, Cao, Bin, Cecconi, Maurizio, Chanda, Duncan, Cooke, Graham, Du, Bin, Dunning, Jake, Geduld, Heike, Gee, Patrick, Hashimi, Madiha, Hui, David S, Kabra, Sushil, Kanda, Seema, Kawano-Dourado, Leticia, Kim, Yae-Jean, Kissoon, Niranjan, Kwizera, Arthur, Laake, Jon Henrik, Machado, Flavia R, Mahaka, Imelda, Manai, Hela, Mino, Greta, Nsutebu, Emmanuel, Pshenichnaya, Natalia, Qadir, Nida, Sabzwari, Saniya, Sarin, Rohit, Sharland, Michael, Shen, Yinzhong, Ranganathan, Shalini Sri, Souza, Joao, Ugarte, Sebastian, Venkatapuram, Sridhar, Dat, Vu Quoc, Vuyiseka, Dubula, Stegemann, Miriam, Wijewickrama, Ananda, Maguire, Brittany, Zeraatkar, Dena, Bartoszko, Jessica, Ge, Long, Brignardello-Petersen, Romina, Owen, Andrew, Guyatt, Gordon, Diaz, Janet, Jacobs, Michael, and Vandvik, Per Olav

Published
2020

13. Remdesivir for severe covid-19 : a clinical practice guideline

Author

Rochwerg, Bram, Agarwal, Arnav, Zeng, Linan, Leo, Yee-Sin, Appiah, John Adabie, Agoritsas, Thomas, Bartoszko, Jessica, Brignardello-Petersen, Romina, Ergan, Begum, Ge, Long, Geduld, Heike, Gershengorn, Hayley B, Manai, Hela, Huang, Minhua, Lamontagne, François, Kanda, Seema, Kawano-Dourado, Leticia, Kurian, Linda, Kwizera, Arthur, Murthy, Srinivas, Qadir, Nida, Siemieniuk, Reed, Silvestre, Maria Asuncion, Vandvik, Per Olav, Ye, Zhikang, Zeraatkar, Dena, and Guyatt, Gordon

Published
2020

14. Drug treatments for covid-19 : living systematic review and network meta-analysis

Author

Siemieniuk, Reed AC, Bartoszko, Jessica J, Ge, Long, Zeraatkar, Dena, Izcovich, Ariel, Kum, Elena, Pardo-Hernandez, Hector, Rochwerg, Bram, Lamontagne, Francois, Han, Mi Ah, Liu, Qin, Agarwal, Arnav, Agoritsas, Thomas, Chu, Derek K, Couban, Rachel, Darzi, Andrea, Devji, Tahira, Fang, Bo, Fang, Carmen, Flottorp, Signe Agnes, Foroutan, Farid, Ghadimi, Maryam, Heels-Ansdell, Diane, Honarmand, Kimia, Hou, Liangying, Hou, Xiaorong, Ibrahim, Quazi, Khamis, Assem, Lam, Bonnie, Loeb, Mark, Marcucci, Maura, McLeod, Shelley L, Motaghi, Sharhzad, Murthy, Srinivas, Mustafa, Reem A, Neary, John D, Qasim, Anila, Rada, Gabriel, Riaz, Irbaz Bin, Sadeghirad, Behnam, Sekercioglu, Nigar, Sheng, Lulu, Sreekanta, Ashwini, Switzer, Charlotte, Tendal, Britta, Thabane, Lehana, Tomlinson, George, Turner, Tari, Vandvik, Per O, Vernooij, RobinWM, Viteri-García, Andrés, Wang, Ying, Yao, Liang, Ye, Zhikang, Guyatt, Gordon H, and Brignardello-Petersen, Romina

Published
2020

15. Evaluating the credibility of anchor based estimates of minimal important differences for patient reported outcomes : instrument development and reliability study

Author

Devji, Tahira, Carrasco-Labra, Alonso, Qasim, Anila, Phillips, Mark, Johnston, Bradley C, Devasenapathy, Niveditha, Zeraatkar, Dena, Bhatt, Meha, Jin, Xuejing, Brignardello-Petersen, Romina, Urquhart, Olivia, Foroutan, Farid, Schandelmaier, Stefan, Pardo-Hernandez, Hector, Vernooij, Robin WM, Huang, Hsiaomin, Rizwan, Yamna, Siemieniuk, Reed, Lytvyn, Lyubov, Patrick, Donald L, Ebrahim, Shanil, Furukawa, Toshi, Nesrallah, Gihad, Schünemann, Holger J, Bhandari, Mohit, Thabane, Lehana, and Guyatt, Gordon H

Published
2020

19. Minimal important difference estimates for patient-reported outcomes: A systematic survey

Author

Carrasco-Labra, Alonso, Devji, Tahira, Qasim, Anila, Phillips, Mark R., Wang, Yuting, Johnston, Bradley C., Devasenapathy, Niveditha, Zeraatkar, Dena, Bhatt, Meha, Jin, Xuejing, Brignardello-Petersen, Romina, Urquhart, Olivia, Foroutan, Farid, Schandelmaier, Stefan, Pardo-Hernandez, Hector, Hao, Qiukui, Wong, Vanessa, Ye, Zhikang, Yao, Liam, Vernooij, Robin W.M., Huang, Hsiaomin, Zeng, Linan, Rizwan, Yamna, Siemieniuk, Reed, Lytvyn, Lyubov, Patrick, Donald L., Ebrahim, Shanil, Furukawa, Toshi A., Nesrallah, Gihad, Schünemann, Holger J., Bhandari, Mohit, Thabane, Lehana, and Guyatt, Gordon H.

Published
2021
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21. GRADE Guidelines 28: Use of GRADE for the assessment of evidence about prognostic factors: rating certainty in identification of groups of patients with different absolute risks

Author

Foroutan, Farid, Guyatt, Gordon, Zuk, Victoria, Vandvik, Per Olav, Alba, Ana Carolina, Mustafa, Reem, Vernooij, Robin, Arevalo-Rodriguez, Ingrid, Munn, Zachary, Roshanov, Pavel, Riley, Richard, Schandelmaier, Stefan, Kuijpers, Ton, Siemieniuk, Reed, Canelo-Aybar, Carlos, Schunemann, Holger, and Iorio, Alfonso

Published
2020
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22. Management of chronic pain associated with temporomandibular disorders: a clinical practice guideline

Author

Busse, Jason W, primary, Casassus, Rodrigo, additional, Carrasco-Labra, Alonso, additional, Durham, Justin, additional, Mock, David, additional, Zakrzewska, Joanna M, additional, Palmer, Carolyn, additional, Samer, Caroline F, additional, Coen, Matteo, additional, Guevremont, Bruno, additional, Hoppe, Thomas, additional, Guyatt, Gordon H, additional, Crandon, Holly N, additional, Yao, Liang, additional, Sadeghirad, Behnam, additional, Vandvik, Per O, additional, Siemieniuk, Reed A C, additional, Lytvyn, Lyuba, additional, Hunskaar, Birk Stokke, additional, and Agoritsas, Thomas, additional

Published
2023
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23. Colorectal cancer screening with faecal immunochemical testing, sigmoidoscopy or colonoscopy : a clinical practice guideline

Author

Helsingen, Lise M, Vandvik, Per Olav, Jodal, Henriette C, Agoritsas, Thomas, Lytvyn, Lyubov, Anderson, Joseph C, Auer, Reto, Murphy, Silje Bjerkelund, Almadi, Majid Abdulrahman, Corley, Douglas A, Quinlan, Casey, Fuchs, Jonathan M, McKinnon, Annette, Qaseem, Amir, Heen, Anja Fog, Siemieniuk, Reed A C, Kalager, Mette, Usher-Smith, Juliet A, Lansdorp-Vogelaar, Iris, Bretthauer, Michael, and Guyatt, Gordon

Published
2019

25. Efficacy and safety of gastrointestinal bleeding prophylaxis in critically ill patients: an updated systematic review and network meta-analysis of randomized trials

Author

Wang, Ying, Ge, Long, Ye, Zhikang, Siemieniuk, Reed A., Reintam Blaser, Annika, Wang, Xin, and Perner, Anders

Subjects
Mortality -- Canada, Histamine -- Health aspects, Gastrointestinal bleeding -- Health aspects, Proton pump inhibitors -- Health aspects, Health care industry
Abstract

Purpose Motivated by a new randomized trial (the PEPTIC trial) that raised the issue of an increase in mortality with proton pump inhibitors (PPIs) relative to histamine-2 receptor antagonists (H2RAs), we updated our prior systematic review and network meta-analysis (NMA) addressing the impact of pharmacological gastrointestinal bleeding prophylaxis in critically ill patients. Methods We searched for randomized controlled trials that examined the efficacy and safety of gastrointestinal bleeding prophylaxis with PPIs, H2RAs, or sucralfate versus one another or placebo or no prophylaxis in adult critically ill patients. We performed Bayesian random-effects NMA and conducted analyses using all PEPTIC data as well as a restricted analysis using only PEPTIC data from high compliance centers. We used the GRADE approach to quantify absolute effects and assess the certainty of evidence. Results Seventy-four trials enrolling 39 569 patients proved eligible. Both PPIs (risk ratio (RR) 1.03, 95% credible interval 0.93 to 1.14, moderate certainty) and H2RAs (RR 0.98, 0.89 to 1.08, moderate certainty) probably have little or no impact on mortality compared with no prophylaxis. There may be no important difference between PPIs and H2RAs on mortality (RR 1.05, 0.97 to 1.14, low certainty), the 95% credible interval of the complete analysis has not excluded an important increase in mortality with PPIs. Both PPIs (RR 0.46, 0.29 to 0.66) and H2RAs (RR 0.67, 0.48 to 0.94) probably reduce clinically important gastrointestinal bleeding; the magnitude of reduction is probably greater in PPIs than H2RAs (RR 0.69, 0.45 to 0.93), and the difference may be important in higher, but not lower bleeding risk patients. PPIs (RR 1.08, 0.88 to 1.45, low certainty) and H2RAs (RR 1.07, 0.85 to 1.37, low certainty) may have no important impact on pneumonia compared with no prophylaxis. Conclusion This updated NMA confirmed that PPIs and H2RAs are most likely to have a similar effect on mortality compared to each other and compared to no prophylaxis; however, the possibility that PPIs may slightly increase mortality cannot be excluded (low certainty evidence). PPIs and H2RAs probably achieve important reductions in clinically important gastrointestinal bleeding; for higher bleeding risk patients, the greater benefit of PPIs over H2RAs may be important. PPIs or H2RAs may not result in important increases in pneumonia but the certainty of evidence is low., Author(s): Ying Wang [sup.1], Long Ge [sup.2], Zhikang Ye [sup.1], Reed A. Siemieniuk [sup.1] [sup.3], Annika Reintam Blaser [sup.4] [sup.5], Xin Wang [sup.6], Anders Perner [sup.7], Morten H. Møller [sup.7], [...]

Published
2020
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28. Corticosteroids in Patients Hospitalized With Community-Acquired Pneumonia : Systematic Review and Individual Patient Data Metaanalysis

Author

Ovidius Study Group, Capisce Study Group, and STEP Study Group, Briel, Matthias, Spoorenberg, Simone M. C., Snijders, Dominic, Torres, Antoni, Fernandez-Serrano, Silvia, Meduri, G. Umberto, Gabarrús, Albert, Blum, Claudine A., Confalonieri, Marco, Kasenda, Benjamin, Siemieniuk, Reed A.C., Boersma, Wim, Bos, Willem Jan W., and Christ-Crain, Mirjam

Published
2018

30. Evidence-based guidelines for supportive care of patients with Ebola virus disease

Author

Lamontagne, François, Fowler, Robert A, Adhikari, Neill K, Murthy, Srinivas, Brett-Major, David M, Jacobs, Michael, Uyeki, Timothy M, Vallenas, Constanza, Norris, Susan L, Fischer, William A, 2nd, Fletcher, Thomas E, Levine, Adam C, Reed, Paul, Bausch, Daniel G, Gove, Sandy, Hall, Andrew, Shepherd, Susan, Siemieniuk, Reed A, Lamah, Marie-Claude, Kamara, Rashida, Nakyeyune, Phiona, Soka, Moses J, Edwin, Ama, Hazzan, Afeez A, Jacob, Shevin T, Elkarsany, Mubarak Mustafa, Adachi, Takuya, Benhadj, Lynda, Clément, Christophe, Crozier, Ian, Garcia, Armando, Hoffman, Steven J, and Guyatt, Gordon H

Published
2018
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32. Living systematic reviews: 4. Living guideline recommendations

Author

Agoritsas, Thomas, Hilton, John, Perron, Caroline, Akl, Elie, Hodder, Rebecca, Pestridge, Charlotte, Albrecht, Lauren, Horsley, Tanya, Platt, Joanne, Armstrong, Rebecca, Nguyen, Phi Hung, Plovnick, Robert, Arno, Anneliese, Ivers, Noah, Quinn, Gail, Au, Agnes, Johnston, Renea, Rada, Gabriel, Bagg, Matthew, Jones, Arwel, Ravaud, Philippe, Boden, Catherine, Kahale, Lara, Richter, Bernt, Boisvert, Isabelle, Keshavarz, Homa, Ryan, Rebecca, Brandt, Linn, Kolakowsky-Hayner, Stephanie A., Salama, Dina, Brazinova, Alexandra, Nagraj, Sumanth Kumbargere, Salanti, Georgia, Buchbinder, Rachelle, Lasserson, Toby, Santaguida, Lina, Champion, Chris, Lawrence, Rebecca, Santesso, Nancy, Chandler, Jackie, Les, Zbigniew, Schünemann, Holger J., Charidimou, Andreas, Leucht, Stefan, Shemilt, Ian, Chou, Roger, Low, Nicola, Sherifali, Diana, Churchill, Rachel, Maas, Andrew, Siemieniuk, Reed, Cnossen, Maryse C., MacLehose, Harriet, Simmonds, Mark, Cossi, Marie-Joelle, Macleod, Malcolm, Skoetz, Nicole, Counotte, Michel, Marshall, Iain, Soares-Weiser, Karla, Craigie, Samantha, Marshall, Rachel, Srikanth, Velandai, Dahm, Philipp, Martin, Nicole, Sullivan, Katrina, Danilkewich, Alanna, Martínez García, Laura, Synnot, Anneliese, Danko, Kristen, Mavergames, Chris, Taylor, Mark, Donoghue, Emma, Maxwell, Lara J., Thayer, Kris, Dressler, Corinna, McAuley, James, Thomas, James, Egan, Cathy, McDonald, Steve, Tritton, Roger, Elliott, Julian, McKenzie, Joanne, Tsafnat, Guy, Elliott, Sarah A., Meerpohl, Joerg, Tugwell, Peter, Etxeandia, Itziar, Merner, Bronwen, Turgeon, Alexis, Featherstone, Robin, Mondello, Stefania, Turner, Tari, Foxlee, Ruth, Morley, Richard, van Valkenhoef, Gert, Garner, Paul, Munafo, Marcus, Vandvik, Per, Gerrity, Martha, Munn, Zachary, Wallace, Byron, Glasziou, Paul, Murano, Melissa, Wallace, Sheila A., Green, Sally, Newman, Kristine, Watts, Chris, Grimshaw, Jeremy, Nieuwlaat, Robby, Weeks, Laura, Gurusamy, Kurinchi, Nikolakopoulou, Adriani, Weigl, Aaron, Haddaway, Neal, Noel-Storr, Anna, Wells, George, Hartling, Lisa, O'Connor, Annette, Wiercioch, Wojtek, Hayden, Jill, Page, Matthew, Wolfenden, Luke, Helfand, Mark, Pahwa, Manisha, Yepes Nuñez, Juan José, Higgins, Julian, Pardo, Jordi Pardo, Yost, Jennifer, Hill, Sophie, Pearson, Leslea, Akl, Elie A., Meerpohl, Joerg J., and Kahale, Lara A.

Published
2017
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33. Living systematic reviews: 3. Statistical methods for updating meta-analyses

Author

Agoritsas, Thomas, Hilton, John, Perron, Caroline, Akl, Elie, Hodder, Rebecca, Pestridge, Charlotte, Albrecht, Lauren, Horsley, Tanya, Platt, Joanne, Armstrong, Rebecca, Nguyen, Phi Hung, Plovnick, Robert, Arno, Anneliese, Ivers, Noah, Quinn, Gail, Au, Agnes, Johnston, Renea, Rada, Gabriel, Bagg, Matthew, Jones, Arwel, Ravaud, Philippe, Boden, Catherine, Kahale, Lara, Richter, Bernt, Boisvert, Isabelle, Keshavarz, Homa, Ryan, Rebecca, Brandt, Linn, Kolakowsky-Hayner, Stephanie A., Salama, Dina, Brazinova, Alexandra, Nagraj, Sumanth Kumbargere, Salanti, Georgia, Buchbinder, Rachelle, Lasserson, Toby, Santaguida, Lina, Champion, Chris, Lawrence, Rebecca, Santesso, Nancy, Chandler, Jackie, Les, Zbigniew, Schünemann, Holger J., Charidimou, Andreas, Leucht, Stefan, Shemilt, Ian, Chou, Roger, Low, Nicola, Sherifali, Diana, Churchill, Rachel, Maas, Andrew, Siemieniuk, Reed, Cnossen, Maryse C., MacLehose, Harriet, Simmonds, Mark, Cossi, Marie-Joelle, Macleod, Malcolm, Skoetz, Nicole, Counotte, Michel, Marshall, Iain, Soares-Weiser, Karla, Craigie, Samantha, Marshall, Rachel, Srikanth, Velandai, Dahm, Philipp, Martin, Nicole, Sullivan, Katrina, Danilkewich, Alanna, Martínez García, Laura, Synnot, Anneliese, Danko, Kristen, Mavergames, Chris, Taylor, Mark, Donoghue, Emma, Maxwell, Lara J., Thayer, Kris, Dressler, Corinna, McAuley, James, Thomas, James, Egan, Cathy, McDonald, Steve, Tritton, Roger, Elliott, Julian, McKenzie, Joanne, Tsafnat, Guy, Elliott, Sarah A., Meerpohl, Joerg, Tugwell, Peter, Etxeandia, Itziar, Merner, Bronwen, Turgeon, Alexis, Featherstone, Robin, Mondello, Stefania, Turner, Tari, Foxlee, Ruth, Morley, Richard, van Valkenhoef, Gert, Garner, Paul, Munafo, Marcus, Vandvik, Per, Gerrity, Martha, Munn, Zachary, Wallace, Byron, Glasziou, Paul, Murano, Melissa, Wallace, Sheila A., Green, Sally, Newman, Kristine, Watts, Chris, Grimshaw, Jeremy, Nieuwlaat, Robby, Weeks, Laura, Gurusamy, Kurinchi, Nikolakopoulou, Adriani, Weigl, Aaron, Haddaway, Neal, Noel-Storr, Anna, Wells, George, Hartling, Lisa, O'Connor, Annette, Wiercioch, Wojtek, Hayden, Jill, Page, Matthew, Wolfenden, Luke, Helfand, Mark, Pahwa, Manisha, Yepes Nuñez, Juan José, Higgins, Julian, Pardo, Jordi Pardo, Yost, Jennifer, Hill, Sophie, and Pearson, Leslea

Published
2017
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34. Living systematic review: 1. Introduction—the why, what, when, and how

Author

Agoritsas, Thomas, Hilton, John, Perron, Caroline, Akl, Elie, Hodder, Rebecca, Pestridge, Charlotte, Albrecht, Lauren, Horsley, Tanya, Platt, Joanne, Armstrong, Rebecca, Nguyen, Phi Hung, Plovnick, Robert, Arno, Anneliese, Ivers, Noah, Quinn, Gail, Au, Agnes, Johnston, Renea, Rada, Gabriel, Bagg, Matthew, Jones, Arwel, Ravaud, Philippe, Boden, Catherine, Kahale, Lara, Richter, Bernt, Boisvert, Isabelle, Keshavarz, Homa, Ryan, Rebecca, Brandt, Linn, Kolakowsky-Hayner, Stephanie A., Salama, Dina, Brazinova, Alexandra, Nagraj, Sumanth Kumbargere, Salanti, Georgia, Buchbinder, Rachelle, Lasserson, Toby, Santaguida, Lina, Champion, Chris, Lawrence, Rebecca, Santesso, Nancy, Chandler, Jackie, Les, Zbigniew, Schünemann, Holger J., Charidimou, Andreas, Leucht, Stefan, Shemilt, Ian, Chou, Roger, Low, Nicola, Sherifali, Diana, Churchill, Rachel, Maas, Andrew, Siemieniuk, Reed, Cnossen, Maryse C., MacLehose, Harriet, Simmonds, Mark, Cossi, Marie-Joelle, Macleod, Malcolm, Skoetz, Nicole, Counotte, Michel, Marshall, Iain, Soares-Weiser, Karla, Craigie, Samantha, Marshall, Rachel, Srikanth, Velandai, Dahm, Philipp, Martin, Nicole, Sullivan, Katrina, Danilkewich, Alanna, Martínez García, Laura, Synnot, Anneliese, Danko, Kristen, Mavergames, Chris, Taylor, Mark, Donoghue, Emma, Maxwell, Lara J., Thayer, Kris, Dressler, Corinna, McAuley, James, Thomas, James, Egan, Cathy, McDonald, Steve, Tritton, Roger, Elliott, Julian, McKenzie, Joanne, Tsafnat, Guy, Elliott, Sarah A., Meerpohl, Joerg, Tugwell, Peter, Etxeandia, Itziar, Merner, Bronwen, Turgeon, Alexis, Featherstone, Robin, Mondello, Stefania, Turner, Tari, Foxlee, Ruth, Morley, Richard, van Valkenhoef, Gert, Garner, Paul, Munafo, Marcus, Vandvik, Per, Gerrity, Martha, Munn, Zachary, Wallace, Byron, Glasziou, Paul, Murano, Melissa, Wallace, Sheila A., Green, Sally, Newman, Kristine, Watts, Chris, Grimshaw, Jeremy, Nieuwlaat, Robby, Weeks, Laura, Gurusamy, Kurinchi, Nikolakopoulou, Adriani, Weigl, Aaron, Haddaway, Neal, Noel-Storr, Anna, Wells, George, Hartling, Lisa, O'Connor, Annette, Wiercioch, Wojtek, Hayden, Jill, Page, Matthew, Wolfenden, Luke, Helfand, Mark, Pahwa, Manisha, Yepes Nuñez, Juan José, Higgins, Julian, Pardo, Jordi Pardo, Yost, Jennifer, Hill, Sophie, Pearson, Leslea, Elliott, Julian H., Akl, Elie A., and Tovey, David

Published
2017
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35. Living systematic reviews: 2. Combining human and machine effort

Author

Agoritsas, Thomas, Hilton, John, Perron, Caroline, Akl, Elie, Hodder, Rebecca, Pestridge, Charlotte, Albrecht, Lauren, Horsley, Tanya, Platt, Joanne, Armstrong, Rebecca, Nguyen, Phi Hung, Plovnick, Robert, Arno, Anneliese, Ivers, Noah, Quinn, Gail, Au, Agnes, Johnston, Renea, Rada, Gabriel, Bagg, Matthew, Jones, Arwel, Ravaud, Philippe, Boden, Catherine, Kahale, Lara, Richter, Bernt, Boisvert, Isabelle, Keshavarz, Homa, Ryan, Rebecca, Brandt, Linn, Kolakowsky-Hayner, Stephanie A., Salama, Dina, Brazinova, Alexandra, Nagraj, Sumanth Kumbargere, Salanti, Georgia, Buchbinder, Rachelle, Lasserson, Toby, Santaguida, Lina, Champion, Chris, Lawrence, Rebecca, Santesso, Nancy, Chandler, Jackie, Les, Zbigniew, Schünemann, Holger J., Charidimou, Andreas, Leucht, Stefan, Shemilt, Ian, Chou, Roger, Low, Nicola, Sherifali, Diana, Churchill, Rachel, Maas, Andrew, Siemieniuk, Reed, Cnossen, Maryse C., MacLehose, Harriet, Simmonds, Mark, Cossi, Marie-Joelle, Macleod, Malcolm, Skoetz, Nicole, Counotte, Michel, Marshall, Iain, Soares-Weiser, Karla, Craigie, Samantha, Marshall, Rachel, Srikanth, Velandai, Dahm, Philipp, Martin, Nicole, Sullivan, Katrina, Danilkewich, Alanna, Martínez García, Laura, Synnot, Anneliese, Danko, Kristen, Mavergames, Chris, Taylor, Mark, Donoghue, Emma, Maxwell, Lara J., Thayer, Kris, Dressler, Corinna, McAuley, James, Thomas, James, Egan, Cathy, McDonald, Steve, Tritton, Roger, Elliott, Julian, McKenzie, Joanne, Tsafnat, Guy, Elliott, Sarah A., Meerpohl, Joerg, Tugwell, Peter, Etxeandia, Itziar, Merner, Bronwen, Turgeon, Alexis, Featherstone, Robin, Mondello, Stefania, Turner, Tari, Foxlee, Ruth, Morley, Richard, van Valkenhoef, Gert, Garner, Paul, Munafo, Marcus, Vandvik, Per, Gerrity, Martha, Munn, Zachary, Wallace, Byron, Glasziou, Paul, Murano, Melissa, Wallace, Sheila A., Green, Sally, Newman, Kristine, Watts, Chris, Grimshaw, Jeremy, Nieuwlaat, Robby, Weeks, Laura, Gurusamy, Kurinchi, Nikolakopoulou, Adriani, Weigl, Aaron, Haddaway, Neal, Noel-Storr, Anna, Wells, George, Hartling, Lisa, O'Connor, Annette, Wiercioch, Wojtek, Hayden, Jill, Page, Matthew, Wolfenden, Luke, Helfand, Mark, Pahwa, Manisha, Yepes Nuñez, Juan José, Higgins, Julian, Pardo, Jordi Pardo, Yost, Jennifer, Hill, Sophie, Pearson, Leslea, and McDonald, Steven

Published
2017
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36. Management of chronic pain associated with temporomandibular disorders: a clinical practice guideline.

Author

Busse, Jason W., Casassus, Rodrigo, Carrasco-Labra, Alonso, Durham, Justin, Mock, David, Zakrzewska, Joanna M., Palmer, Carolyn, Samer, Caroline F., Coen, Matteo, Guevremont, Bruno, Hoppe, Thomas, Guyatt, Gordon H., Crandon, Holly N., Liang Yao, Sadeghirad, Behnam, Vandvik, Per O., Siemieniuk, Reed A. C., Lytvyn, Lyuba, Hunskaar, Birk Stokke, and Agoritsas, Thomas

Subjects
CHRONIC pain treatment, NARCOTICS, HEALTH services accessibility, NONSTEROIDAL anti-inflammatory agents, MEDICAL care costs, MEDICAL protocols, RISK assessment, HEALTH care teams, TEMPOROMANDIBULAR disorders, RELAXATION techniques, PAIN management, COGNITIVE therapy, DISEASE complications
Published
2024
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37. Ketamine sedation in the intensive care unit: a survey of Canadian intensivists.

Author

Sharif, Sameer, Munshi, Laveena, Burry, Lisa, Mehta, Sangeeta, Gray, Sara, Chaudhuri, Dipayan, Duffett, Mark, Siemieniuk, Reed A., and Rochwerg, Bram

Abstract

Copyright of Canadian Journal of Anaesthesia / Journal Canadien d'Anesthésie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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38. A living WHO guideline on drugs for covid-19.

Author

Agarwal, Arnav, Hunt, Beverley J., Stegemann, Miriam, Rochwerg, Bram, Lamontagne, François, Siemieniuk, Reed A. C., Agoritsas, Thomas, Askie, Lisa, Lytvyn, Lyubov, Yee-Sin Leo, Macdonald, Helen, Zeng, Linan, Alhadyan, Ahmed, Muna, Al-Maslamani, Amin, Wagdy, Araujo da Silva, André Ricardo, Aryal, Diptesh, Barragan, Fabian A. Jaimes, Bausch, Frederique J., and Burhan, Erlina

Subjects
INTERLEUKINS, COVID-19, ADRENOCORTICAL hormones, HEALTH services accessibility, ANTICOAGULANTS, UNCERTAINTY, DRUGS, HOSPITAL care, RITONAVIR, AZITHROMYCIN, HEALTH equity, MACROLIDE antibiotics
Published
2023
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39. Benefits and harms of drug treatment for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials

Author

Shi, Qingyang, primary, Nong, Kailei, additional, Vandvik, Per Olav, additional, Guyatt, Gordon H, additional, Schnell, Oliver, additional, Rydén, Lars, additional, Marx, Nikolaus, additional, Brosius, Frank C, additional, Mustafa, Reem A, additional, Agarwal, Arnav, additional, Zou, Xinyu, additional, Mao, Yunhe, additional, Asadollahifar, Aminreza, additional, Chowdhury, Saifur Rahman, additional, Zhai, Chunjuan, additional, Gupta, Sana, additional, Gao, Ya, additional, Lima, João Pedro, additional, Numata, Kenji, additional, Qiao, Zhi, additional, Fan, Qinlin, additional, Yang, Qinbo, additional, Jin, Yinghui, additional, Ge, Long, additional, Yang, Qiuyu, additional, Zhu, Hongfei, additional, Yang, Fan, additional, Chen, Zhe, additional, Lu, Xi, additional, He, Siyu, additional, Chen, Xiangyang, additional, Lyu, Xiafei, additional, An, Xingxing, additional, Chen, Yaolong, additional, Hao, Qiukui, additional, Standl, Eberhard, additional, Siemieniuk, Reed, additional, Agoritsas, Thomas, additional, Tian, Haoming, additional, and Li, Sheyu, additional

Published
2023
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41. Effectiveness of Transmitted Drug Resistance Testing Before Initiation of Antiretroviral Therapy in HIV-Positive Individuals

Author

Lodi, Sara, Günthard, Huldrych F., Gill, John, Phillips, Andrew N., Dunn, David, Vu, Quang, Siemieniuk, Reed, Garcia, Federico, Logan, Roger, Jose, Sophie, Bucher, Heiner C., Scherrer, Alexandra U., Reiss, Peter, van Sighem, Ard, Boender, T. Sonia, Porter, Kholoud, Gilson, Richard, Paraskevis, Dimitrios, Simeon, Metallidis, Vourli, Georgia, Moreno, Santiago, Jarrin, Inmaculada, Sabin, Caroline, and Hernán, Miguel A.

Published
2019
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43. Antibiotic Prophylaxis in the Management of Open Fractures: A Systematic Survey of Current Practice and Recommendations

Author

Chang, Yaping, Bhandari, Mohit, Zhu, Kan Lun, Mirza, Reza Donald, Ren, Melody, Kennedy, Sean Alexander, Negm, Ahmed, Bhatnagar, Neera, Naji, Faysal N., Milovanovic, Lazar, Fei, Yutong, Agarwal, Arnav, Kamran, Rakhshan, Cho, Sung Min, Schandelmaier, Stefan, Wang, Li, Jin, Lin, Hu, Shiyun, Zhao, Yanping, Lopes, Luciane Cruz, Wang, Mei, Petrisor, Brad, Ristevski, Bill, Siemieniuk, Reed A.C., and Guyatt, Gordon H.

Published
2019
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44. The authors reply

Author

Oczkowski, Simon J., Rochwerg, Bram, Alhazzani, Waleed, Siemieniuk, Reed A. C., Annane, Djillali, and Guyatt, Gordon

Published
2019
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46. The authors reply

Author

Rochwerg, Bram, Oczkowski, Simon J., Alhazzani, Waleed, Guyatt, Gordon, Annane, Djillali, and Siemieniuk, Reed A. C.

Published
2018
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49. Mycobacterium avium complex infection presenting as persistent ascites

Author

Auguste, Bourne L., Patel, Ashish D., and Siemieniuk, Reed A.

Subjects
Ultrasound imaging -- Usage, History of medicine -- Analysis, Mycobacterium infections -- Case studies -- Diagnosis -- Care and treatment, Health
Abstract

A 53-year-old man presented to hospital with a six-month history of weight gain, peripheral edema and abdominal distention. The patient's past medical history included a renal cadaveric transplant in 2016, [...]

Published
2018
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50. Comparative efficacy and safety of alternative glucocorticoids regimens in patients with ANCA-associated vasculitis: a systematic review

Author

Xiao, Yingqi, Guyatt, Gordon, Zeng, Linan, Rw Jayne, David, A Merkel, Peter, Ac Siemieniuk, Reed, Dookie, Jared E, A Buchan, Tayler, Ahmed, Muhammad Muneeb, J Couban, Rachel, Mahr, Alfred, Walsh, Michael, Xiao, Yingqi [0000-0001-8766-5184], Zeng, Linan [0000-0001-9892-2000], Ac Siemieniuk, Reed [0000-0002-3725-3031], Ahmed, Muhammad Muneeb [0000-0003-4208-6247], Walsh, Michael [0000-0001-8292-2014], and Apollo - University of Cambridge Repository

Subjects
clinical trials, haematology, oral medicine, Humans, Kidney Failure, Chronic, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Glucocorticoids
Abstract

OBJECTIVE: To compare the efficacy and safety of alternative glucocorticoids (GCs) regimens as induction therapy for patients with antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis. DESIGN: Systematic review of randomised controlled trials (RCTs). DATA SOURCES: Medline, Embase, Clinicaltrials.gov and Cochrane Central Register of Controlled Trials up to 10 April 2020. STUDY SELECTION AND REVIEW METHODS: RCTs comparing two (or more) different dose regimens of GC in ANCA-associated vasculitis during induction of remission, regardless of other therapies. Pairs of reviewers independently screened records, extracted data and assessed risk of bias. Two reviewers rated certainty of evidence using the Grading of Recommendations Assessment, Development, and Evaluation approach. RESULTS: Of 3912 records identified, the full texts of two records met the eligibility criteria. Due to the heterogeneity of population and dose regimen of GCs between the two trials, we descriptively presented the two trials and did not combine the results using meta-analysis. Compared with the standard-dose regimen, the reduced-dose regimen of GC may reduce death risk difference (RD): from -1.7% to -2.1%, low certainty), while not increasing end-stage kidney disease (ESKD) (RD: from -1.5% to 0.4%, moderate certainty). The reduced-dose regimen probably has an important reduction in serious infections at 1 year (RD: from -12.8% to -5.9%, moderate certainty). Reduced-dose regimen of GCs probably has trivial or no effect in disease remission, relapse or health-related quality of life (moderate to high certainty). CONCLUSIONS: The reduced-dose regimen of GC may reduce death at the follow-up of 6 months to longer than 1 year and serious infections while not increasing ESKD. PROSPERO REGISTRATION NUMBER: CRD42020179087.

Published
2022
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