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Beschreibung: Evidenzbasierte Gesundheitsinformationen stützen sich auf das beste aktuelle Wissen und folgen den Anforderungen der „Guten Praxis Gesundheitsinformationen“ [ref:1]. Diese verlangt u. a. den Verzicht auf direktive Empfehlungen sowie eine angemessene Darstellung[zum vollständigen Text gelangen Sie über die oben angegebene URL], Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin

Hintergrund: Laut Statistischem Bundesamt hatten 2016 mehr als 18 Millionen Menschen in Deutschland einen Migrationshintergrund. Die Studienlage zeigt, dass diese Menschen erhöhte Gesundheitsrisiken und eine geringere Gesundheitskompetenz im Vergleich zur Allgemeinbevölkerung haben. Ein Arztgespräch[zum vollständigen Text gelangen Sie über die oben angegebene URL], 17. Deutscher Kongress für Versorgungsforschung (DKVF)

M@n@gement offers here a mosaic of short and reflexive essays dedicated to the topic: #TimeIsUp, Academics and Organization Studies. Papers may engage in a poetic, controversial, academic, auto-ethnographical, or fictional style but all share strong ideas around the question of academia, gender and organizing.

This study aimed to identify indicators for an increased frequency of recurrent or metastatic disease in women with mammary carcinoma staged negative for nodal involvement.202/270 patients (age: mean 57.5, range 24-83 years) with histologically confirmed early stage mammary carcinoma negative for metastasis to the sentinel lymph nodes (SLN) were observed with respect to their clinical course for a mean period of 3.6 years following SLN extirpation.Forty of 202 patients with negative SLN underwent chemotherapy (38/188 in the recurrence-free group vs. 2/14 in the group with progressive disease) and 79% of both subcollectives did not undergo chemotherapy. Seven of 188 of patients in the recurrence-free group received immunotherapy and none of the patients in the group with disease progression were treated with this modality. One hundred sixty-two of 202 patients with negative SLN underwent hormone therapy, 157/188 in the recurrence-free group and 5/14 in the group with disease progression. One hundred sixty-four of 202 patients with negative nodal status received adjuvant radiation therapy of the affected breast, 156/188 in the recurrence-free group and 8/14 in the group with disease progression.When assessing the risk profile for disease recurrence or the occurrence of metastatic disease, statistically significant differences with respect to disease progression were identified for the parameters chemo-, antibody, hormone, and radiation therapy. The preliminary observations of this study show that even those patients in an early disease stage and with negative SLNs profit from these adjuvant non-surgical therapy options.

Zielsetzung: In dem Workshop soll der Frage nachgegangen werden, wie hochwertige Gesundheitsinformationen erstellt werden können, die nicht direkt Krankheiten betreffen und auf die daher manche Anforderungen an evidenzbasierte Gesundheitsinformationen nicht übertragbar sind. Dabei soll es [zum vollständigen Text gelangen Sie über die oben angegebene URL], Klasse statt Masse – wider die wertlose Wissenschaft; 18. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin

Hintergrund und Fragestellung: Für Ärzte ist es oft nicht leicht, Leitlinienempfehlungen den Patienten zu vermitteln. So kann das Gespräch schwierig sein, wenn Kranke Erwartungen an Untersuchungen oder Behandlungen haben oder Maßnahmen einfordern, die im Widerspruch zur aktuellen[zum vollständigen Text gelangen Sie über die oben angegebene URL], Klasse statt Masse – wider die wertlose Wissenschaft; 18. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin

In numerical weather prediction, ensembles are used to retrieve probabilistic forecasts of future weather conditions. We consider events where the verification is smaller than the smallest, or larger than the largest ensemble member of a scalar ensemble forecast. These events are called outliers. In a statistically consistent K-member ensemble, outliers should occur with a base rate of 2/(K+1). In operational ensembles this base rate tends to be higher. We study the predictability of outlier events in terms of the Brier Skill Score and find that forecast probabilities can be calculated which are more skillful than the unconditional base rate. This is shown analytically for statistically consistent ensembles. Using logistic regression, forecast probabilities for outlier events in an operational ensemble are calculated. These probabilities exhibit positive skill which is quantitatively similar to the analytical results. Possible causes of these results as well as their consequences for ensemble interpretation are discussed.

Dupuytren´s disease, a fibromatosis of the connective tissue in the palm, is a common complex disease with a strong genetic component. Up to date nine genetic loci have been found to be associated with the disease. Six of these loci contain genes that code for Wnt signalling proteins. In spite of this striking first insight into the genetic factors in Dupuytren´s disease, much of the inherited risk in Dupuytren´s disease still needs to be discovered. The already identified loci jointly explain ~1% of the heritability in this disease. To further elucidate the genetic basis of Dupuytren´s disease, we performed a genome-wide meta-analysis combining three genome-wide association study (GWAS) data sets, comprising 1,580 cases and 4,480 controls. We corroborated all nine previously identified loci, six of these with genome-wide significance (p-value < 5x10-8). In addition, we identified 14 new suggestive loci (p-value < 10-5). Intriguingly, several of these new loci contain genes associated with Wnt signalling and therefore represent excellent candidates for replication. Next, we compared whole-transcriptome data between patient- and control-derived tissue samples and found the Wnt/β-catenin pathway to be the top deregulated pathway in patient samples. We then conducted network and pathway analyses in order to identify protein networks that are enriched for genes highlighted in the GWAS meta-analysis and expression data sets. We found further evidence that the Wnt signalling pathways in conjunction with other pathways may play a critical role in Dupuytren´s disease.

Background Cow's milk allergy (CMA) is one of the most commonly reported childhood food problems. Community-based incidence and prevalence estimates vary widely, due to possible misinterpretations of presumed reactions to milk and differences in study design, particularly diagnostic criteria. Methods Children from the EuroPrevall birth cohort in 9 European countries with symptoms possibly related to CMA were invited for clinical evaluation including cows' milk-specific IgE antibodies (IgE), skin prick test (SPT) reactivity and double-blind, placebo-controlled food challenge. Results Across Europe, 12 049 children were enrolled, and 9336 (77.5%) were followed up to 2 years of age. CMA was suspected in 358 children and confirmed in 55 resulting in an overall incidence of challenge-proven CMA of 0.54% (95% CI 0.41-0.70). National incidences ranged from 1% (in the Netherlands and UK) to