433 results on '"Siebold, Christian"'
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2. Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling
3. Mapping structural and dynamic divergence across the MBOAT family
4. Diverse genetic causes of amenorrhea in an ethnically homogeneous cohort and an evolving approach to diagnosis
5. LipIDens: simulation assisted interpretation of lipid densities in cryo-EM structures of membrane proteins
6. Rocking the MBOAT: Structural insights into the membrane bound O-acyltransferase family
7. Cilia-Associated Oxysterols Activate Smoothened
8. Structure, mechanism, and inhibition of Hedgehog acyltransferase
9. Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex
10. Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling
11. Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling
12. iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition
13. Cholesterol access in cellular membranes controls Hedgehog signaling
14. Glypicans shield the Wnt lipid moiety to enable signalling at a distance
15. Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling
16. Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling
17. Cholesterol Interaction Sites on the Transmembrane Domain of the Hedgehog Signal Transducer and Class F G Protein-Coupled Receptor Smoothened
18. Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase
19. Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates
20. The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism
21. High-Resolution Structure of the Catalytic Region of MICAL (Molecule Interacting with CasL), a Multidomain Flavoenzyme-Signaling Molecule
22. Crystal Structure of HLA-DQ0602 That Protects against Type 1 Diabetes and Confers Strong Susceptibility to Narcolepsy
23. A Mechanism of Covalent Substrate Binding in the X-Ray Structure of Subunit K of the Escherichia coli Dihydroxyacetone Kinase
24. RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling
25. Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins
26. The energetics and ion coupling of cholesterol transport through Patched1
27. Structural basis for integration of GluD receptors within synaptic organizer complexes
28. Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning
29. Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases
30. Structural basis of smoothened regulation by its extracellular domains
31. Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP
32. Structural insights into semaphorins and their receptors
33. Structural insights into proteoglycan-shaped Hedgehog signaling
34. Structure of the Repulsive Guidance Molecule (RGM)–Neogenin Signaling Hub
35. The Inseparable Relationship Between Cholesterol and Hedgehog Signaling.
36. LipIDens: Simulation assisted interpretation of lipid densities in cryo-EM structures of membrane proteins
37. Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain
38. Proteoglycan-Specific Molecular Switch for RPTPσ Clustering and Neuronal Extension
39. Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling
40. Automation of large scale transient protein expression in mammalian cells
41. Structure of a Tyrosine Phosphatase Adhesive Interaction Reveals a Spacer-Clamp Mechanism
42. Lipid-like to lipid-site: a protocol for simulation assisted interpretation of cryo-EM densities
43. Crystal Structure of Enzyme I of the Phosphoenolpyruvate Sugar Phosphotransferase System in the Dephosphorylated State
44. Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling
45. An Ion-channel Modulator from the Saliva of the Brown Ear Tick has a Highly Modified Kunitz/BPTI Structure
46. Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes
47. Author response: Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes
48. Relative Affinities of Protein–Cholesterol Interactions from Equilibrium Molecular Dynamics Simulations
49. Biochemical and Structural Studies of ASPP Proteins Reveal Differential Binding to p53, p63, and p73
50. Structural basis of semaphorin-plexin signalling
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