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2. Parallel tubular arrays in severe combined immunodeficiency disease: an ultrastructural study of peripheral blood lymphocytes

Author

Payne, CM, Jones, JF, Sieber, OF Jr, and Fulginiti, VA

Abstract

The ultrastructure of the lymphocytes from three children with severe combined immunodeficiency disease (SCID) is described. Parallel tubular arrays (PTA) were found in a large percentage of circulating lymphocytes (53%, 41%, and 13%) in three SCID patients when compared to age-matched controls. The size of these inclusions was quite variable, with some attaining a length of 1.7 micrometer. They contained a tubular substructure with a diameter of 36--44 nm. The PTA were mostly located in the centriolar and Golgi regions of the cytoplasm, and were sometimes membrane bound. A centriolar origin of the inclusion was suggested. A second inclusion, the tubuloreticular structure, was found in only 1.4% of the circulating lymphocytes from one SCID patient. The origin of the PTA and its occurrence in severe combined immunodeficiency disease are discussed.

Published
1977
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3. Early-warning indicators for tipping points

Author

Ritchie, Paul David Longden Jr and Sieber, Jan Jr

Subjects
331.2, Tipping points, rate-induced, noise-induced, early-warning indicators
Abstract

The term ‘tipping event’ is used to describe a certain class of phenomena as observed in many different fields of science. It refers to an event where a gradual change of external forcing causes a sudden, large, often unwanted, transition to the state of the system. Some examples of known tipping events in science include: Arctic sea ice melting (climate), epileptic seizures (biology), collapse of ecosystems and populations (ecology) and market crashes (finance). Three mathematical mechanisms for tipping events have been proposed in the literature: bifurcation-, noise- or rate-induced tipping. Recent research has focused on developing early-warning indicators to potentially offer forewarning, which can extract from output time series whether the external forcing approaches a critical level at which tipping occurs. Two commonly used early-warning indicators are an increase of autocorrelation and variance in the time series data for the system’s output. The theory behind the presence of these indicators is the loss of stability of the system’s current state known as ‘critical slowing down’ for the approach of a bifurcation-induced tipping. Rate-induced tipping occurs when the external forcing reaches a critical rate instead of level. For rate-induced tipping there is no loss of stability of the system’s current state and therefore it is not clear if the early-warning indicators should exist. In this thesis we investigate the presence of early-warning indicators for models that show rate-induced tipping with additive noise. We also explore a technique for determining the most likely time of tipping using optimal paths for escape. Research has mainly focussed on testing the early-warning indicators for examples of known tipping events in the past. The ultimate aim of early-warning indicators would be to have the ability to predict future tipping events. Using the early-warning indicators in isolation is susceptible to incurring false alarms and missed alarms. We present a method for approximating the probability of experiencing rate-induced tipping with noise for slow to moderate drift speeds.

Published
2016

5. Trimethoprim-sulfamethoxazole treatment of Pneumocystis carinii pneumonitis.

Author

Larter WE, John TJ, Sieber OF Jr, Johnson H, Corrigan JJ Jr, and Fulginiti VA

Subjects
Adolescent, Child, Preschool, Drug Combinations, Female, Humans, Infant, Male, Sulfamethoxazole administration & dosage, Trimethoprim administration & dosage, Pneumonia, Pneumocystis drug therapy, Sulfamethoxazole therapeutic use, Trimethoprim therapeutic use
Published
1978
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6. Pseudomonas cepacia pneumonia in a child with chronic granulomatous disease and selective IgA deficiency.

Author

Sieber OF Jr and Fulginiti VA

Subjects
Child, Humans, Male, Dysgammaglobulinemia complications, Granulomatous Disease, Chronic complications, Immunoglobulin A, Immunologic Deficiency Syndromes complications, Phagocyte Bactericidal Dysfunction complications, Pneumonia immunology, Pseudomonas Infections immunology
Abstract

A 6 1/2 year-old boy with chronic granulomatous disease (CGD) and selective IgA deficiency developed a chronic progressive pneumonia which failed to respond to several conventional combinations of antimicrobial therapy. On lung biopsy, Pseudomonas cepacia was obtained in pure culture, sensitive to chloramphenicol, tetracycline, kanamycin and nalidixic acid. With specific therapy, he slowly recovered. P. cepacia has not been previously described as a cause of persistent pneumonia in immunodeficient children. The occurrence of CGD and selective IgA deficiency together is a very rare combination of immunodeficiencies.

Published
1976
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7. Predominance of B-lymphocyte function after cultured thymus fragment therapy in severe combined immunodeficiency disease.

Author

Jones JF, Sieber OF Jr, Fulginiti VA, Ochs H, Schulte-Wisserman H, and Hong R

Subjects
Concanavalin A pharmacology, Female, Humans, Immunoglobulin G biosynthesis, Infant, Leukocyte Count, Lymphocytes, Phytohemagglutinins pharmacology, Pokeweed Mitogens pharmacology, Receptors, Antigen, B-Cell, Rosette Formation, Skin Tests, B-Lymphocytes immunology, Immunologic Deficiency Syndromes therapy, Thymus Gland transplantation
Published
1980
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9. Respiratory syncytial virus infections. Comments.

Author

Sieber OF Jr

Subjects
Animals, Disease Models, Animal, Haplorhini, Humans, Immunity, Cellular, Infant, Infant, Newborn, Macaca mulatta, Immunoglobulin E, Respiratory Syncytial Viruses immunology, Virus Diseases immunology
Published
1977

10. Coccidioides immitis osteomyelitis of the mandible in an infant.

Author

Sieber OF Jr, Larter W, Smith PJ, Crowe P Jr, and Pitt M

Subjects
Amphotericin B therapeutic use, Child, Preschool, Coccidioides, Coccidioidomycosis diagnostic imaging, Coccidioidomycosis drug therapy, Coccidioidomycosis pathology, Female, Humans, Infant, Mandibular Diseases diagnostic imaging, Mandibular Diseases drug therapy, Mandibular Diseases pathology, Osteomyelitis diagnostic imaging, Osteomyelitis drug therapy, Osteomyelitis pathology, Radiography, Coccidioidomycosis diagnosis, Mandibular Diseases diagnosis, Osteomyelitis diagnosis
Abstract

Coccidioidomycotic osteomyelitis developed at the angle of the right side of the mandible in a 5-month-old Papago infant. The disease was successfully treated with a combination of amphotericin B, surgery, and transfer factor with complete immunological, microbiological, and radiological cure. At 4 years of age, the only residual effect is prominence of the right hemimandible with asymmetry of the jaw.

Published
1977

13. Shigella sepsis.

Author

Duncan B, Fulginiti VA, Sieber OF Jr, and Ryan KJ

Subjects
Child, Preschool, Humans, Infant, Prognosis, Dysentery, Bacillary diagnosis, Dysentery, Bacillary mortality, Sepsis diagnosis, Sepsis mortality
Abstract

It is generally believed that bacteremia rarely occurs with enteric Shigella infections. During a five-year period, 110 children were admitted to the University Hospital of the Arizona Health Sciences Center, Tucson, with Shigella enteritis. Eight (7%) had Shigella bacteremia/septicemia, and four of the eight died. An analysis of these patients and their course disclosed clinical characteristics that were of potential prognostic importance. Some of these indicators are identifiable early and hence could be useful in management. The patients at greatest risk were afebrile; 10% or more dehydrated; malnourished, with a low serum albumin level; infected with ampicillin-resistant strains; had leukopenia during the course of the illness; and had persistent watery hemoglobin-positive stools.

Published
1981
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14. Colorado tick fever encephalitis.

Author

Draughn DE, Sieber OF Jr, and Umlauf JH Jr

Subjects
Animals, Child, Colorado, Diagnosis, Differential, Encephalitis Viruses, Tick-Borne isolation & purification, Humans, Insect Bites and Stings complications, Male, Mice, Meningoencephalitis etiology, Ticks
Published
1965
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16. Stevens-Johnson syndrome associated with Mycoplasma pneumoniae infection.

Author

Sieber OF Jr, John TJ, Fulginiti VA, and Overholt EC

Subjects
Adenoviridae Infections diagnosis, Adult, Antibodies, Complement Fixation Tests, Conjunctivitis, Hemagglutination Inhibition Tests, Humans, Male, Stomatitis, Urethritis, Mycoplasma isolation & purification, Pneumonia diagnosis, Stevens-Johnson Syndrome microbiology
Published
1967

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