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OBJECTIVE: To clarify the epidemiological, diagnostic and therapeutic features and to improve the prognosis of inflammatory breast cancer. MATERIALS AND METHODS: This is a retrospective study from January 1, 2018 to December 31, 2020 including patients with a diagnosis of inflammatory breast cancer. RESULTS: During the study, 1.730 cases of breast cancer were collected, of which 43 cases of inflammatory cancer (2.5%). The average age of the patients was 44.8 years. The average consultation time was 6.4 months. All patients had lymph node involvement. Non-specific infiltrating carcinoma was the histological type found in all cases. All patients received at least a first line of chemotherapy with a better clinical response to taxanes than to anthracyclines. Surgery was performed in 69.76% of cases. Forty percent of patients were alive at the end of the study. CONCLUSION: Inflammatory breast cancer is quite rare at the Joliot-Curie Institute. The diagnosis is late. Early diagnostic and therapeutic management would improve the therapeutic outcome of inflammatory breast cancer. KEYWORDS: Inflammatory breast cancer; Epidemiology; Prognosis.

Background: The objective of this work completed at the Cancer Institute in Dakar is to report the results of inguinal lymph node dissection in cancers of the lower limb and of the lower genital tract. Methods: This is a retrospective study over a 10-year period. The parameters being studied are histological type, lymph node involvement, postoperative morbidity, recurrence, and survival. Results: 81 patients received surgery over a period of 7 years. The average age of our patients was 61. The sex ratio is 0.74 with 34 men and 47 women. There were 70 cases of cancer of the lower limbs (86%) and 11 cases of cancer of the vulva (14%). The most common histological type was squamous cell carcinoma (SCC) with 41 cases (51%). Clinical inguinal involvement was noted in 58 patients (72.5%) with palpable lymph nodes. All vulvar cancer patients developed histologically positive nodes. Melanoma patients were more susceptible to developing positive nodes. In sarcoma there were more matches between clinical and histological positive nodes. No vascular and nerve damage was reported. The average length of hospitalization was 5 days, with 3 days being the shortest stay, and 40 days the longest stay. Local complications consisted of suture releases in 9 cases, and 6 surgical necrosis of the wound. A seroma was found with an average duration of 35 days in 69 patients (85%). Postoperative deaths occurred in 5 cases (6%), 1 after a renal failure, 1 due to thromboembolic disease, 1 due to sepsis, and 2 deaths occurred after patients experienced respiratory distress. Conclusion: After five years of follow-up care, no patient presented chronic sequelae after inguinal dissection, 7 patients (8.75%) had local recurrence, and 4 patients (7.7%) had lymph node metastases. We recorded 33 cancer-related deaths (41%). Chronic complications, including lymphedema are underestimated and require better assessment methods for prevention and treatment.

Objective: Describe the epidemiological, diagnostic, therapeutic and evolutionary profile of triple negative breast cancer at the Dakar Cancer Institute in Senegal. Patients and Methods: This was a retrospective study between January 1, 2011 and December 31, 2014. All patients with a triple negative molecular profile were included. The data were collected from the medical records of the patients. The data were entered and analyzed with SPSS edition 16 software under Windows 7. Results: Two hundred and twenty-five patients were selected. The mean age was 47.9 ± 12.5 years with extremes of 25 and 90 years. The main reason for consultation was dominated by the finding of a breast lump. The mean clinical tumor size was 8, 54 cm with a large majority of T3-T4 tumors 26% and 63% respectively, lymph node involvement in one hundred and seventy-two cases (76.4%); twenty eight patients (12.4%) were metastatic from the outset. Non-specific invasive carcinoma was the most common histologic type (78.2%), and more than half of the patients (53.3%) had an aggressive tumor (Scarff-Bloom-Richardson grading III). Neoadjuvant chemotherapy was performed in 65.78% of cases. We noted 27.7% total response and 41.7% partial response in patients who have received this neoadjuvant chemotherapy. The surgery was radical in 77% of cases, conservative in 14% and cleanliness surgery for palliative purposes in 9% of cases. Adjuvant radiotherapy is performed in 58.6% of operated patients. The mean time to follow-up was 20.63 months with extremes of 1 and 53 months. Overall survival was 69.8% at one year, 41.6% at two years and 25.6% at three years. Conclusion: The descriptive analysis of these results confirms the high frequency of triple-negative breast cancer in Senegal and its poor prognosis.

Objectives: To study the epidemiological, diagnostic, therapeutic and prognostic aspects of gastric adenocarcinoma at the Joliot Curie Institute in Dakar. Materials and Methods: We conducted a retrospective study over a seven-year period from January 2010 to December 2017 at the Joliot Curie Institute in Dakar. All cases of gastric adenocarcinoma proven by fibroscopy followed by histology or proven on the histological analysis of a surgical specimen were taken into account. The parameters studied were age, risk factors, stages of the disease, treatment and prognosis. Results: There were 54 cases of gastric adenocarcinoma over a period of 7 years. The average age was 54.74 years with extremes of 25 and 84 years. A male predominance was noted (35/54). The main risk factors found were alcohol (5/54), tobacco (13/54), Helicobacter pilori (4/54), gastric ulcer (12/54). Epigastralgia was the most frequent clinical manifestation. FOGD was carried out in 77.8% of patients. Histology was obtained before surgery in 40 patients (74.1% of cases) and on the operating room in 14 patients (25.9%). Patients were classified as stage II in 2/54 cases, stage III in 5/54 cases and stage IV in 47/54 cases. Gastro-entero-anastomosis was the main surgical procedure performed. External radiotherapy was performed in 1/54 patients. Chemotherapy was done in 52/54 patients, 96.3% of the cases. It was palliative in 66.7% of cases, neoadjuvant in 1.9% of cases, adjuvant in 24.1% of cases, perioperative in 3.7% of cases. Mortality was 79.6%. Patient survival times were relatively short: in less than 6 months 24/54 cases, 13/54 cases between 6 - 12 months, 5/54 cases between 13 - 24 months and 6/54 cases beyond 24 months. 6/54 patients were lost from view. Conclusion: Gastric adenocarcinoma is diagnosed lately in our conditions. It is responsible for a high mortality rate. Palliative treatment is often the only option because of the delay in diagnosis.

INTRODUCTION: In Senegal, breast cancer is the second female cancer and poses a major public health problem. The aim of this work was to assess prognostic factors in the progression of breast cancer in women. PATIENTS AND METHODS: This is a retrospective study carried out over a period of one year from January 1, 2008 to December 31, 2008 on all the women followed for breast cancer in the oncology department at the Joliot Curie Institute. Thus, 288 breast cancer patients were collected. RESULTS: The average age of our patients was 47.32 years. The average parity was 4.9 children per woman. Twenty-two or 7% of patients had a history of cancer. Clinically, the tumor size was classified as T4 in 180 patients, ie 81%. Lymph node involvement in 188 patients (65.2%). The most frequent histological type was invasive ductal carcinoma with 90.3% of cases. A predominance of grades SBRII and SBRIII was observed (respectively 41% and 46%). Hormone receptors (RH) were positive in eight cases (24%). Overexpression of the HER2 gene was found in only four out of 30 patients. The limits of the surgery were specified in 48 patients with invaded margins in seven patients (14.5%). The presence of vascular emboli was noted in 18 patients among the 29 whose research was carried out in 179 patients, ie 62%. At the time of the initial diagnosis, 45 patients or 19.7% of patients presented at least one distant metastasis. The majority of patients were received at an advanced stage (89%, classified between stage III and IV). Only one patient was received at stage I. Overall survival for breast cancer was 72% at 3 years and 30% at 5 years. The 5-year overall survival of patients with localized disease was 85% compared to 5% for patients with advanced stage. CONCLUSION: The prognostic factors are multiple and often pejorative in our patients with a predominance of young women, locally advanced cancers and aggressive biological forms.

Imperforate hymen is a fairly uncommon genital disorder where the hymen completely obstructs the vaginal opening. Several authors have ruled out its co-occurrence with other congenital anomalies. In this report, we discuss the exceptional case of a late diagnosis of imperforate hymen associated with bilateral hydronephrosis of a horseshoe kidney in a 19-year-old female patient. To our knowledge, an association of imperforate hymen and horseshoe kidney has never been reported.

BRCA1 and BRCA2 are the most incriminated genes in inherited breast/ovarian cancers. Several pathogenic variants of these genes conferring genetic predisposition have been described in different populations but rarely in sub-Saharan Africa. The objectives of this study were to identify pathogenic variants of the BRCA genes involved in hereditary breast cancer in Senegal and to search for a founder effect. We recruited after free informed consent, 27 unrelated index cases diagnosed with breast cancer and each having a family history. Mutation screening of the genes identified a duplication of ten nucleotides c.815_824dupAGCCATGTGG, (p.Thr276Alafs) (NM_007294.3) located in exon 11 of BRCA1 gene, in 15 index cases (allelic frequency 27.7%). The pathogenic variant has been previously reported in African Americans as a founder mutation of West African origin. Haplotypes analysis of seven microsatellites surrounding the BRCA1 gene highlights a shared haplotype encompassing ~400 kb between D17S855 and D17S1325. This haplotype was not detected in none of 15 healthy controls. Estimation of the age of the pathogenic variant suggested that it occurred ~1400 years ago. Our study identified a founder pathogenic variant of BRCA1 predisposing to breast cancer and enabled the establishment of an affordable genetic test as a mean of prevention for Senegalese women at risk.

Introduction: The principal postoperative complication of mastectomies with axillary dissection is the lymphocele that can last many months after surgery. The purpose of our study was to prevent its formation using the padding. Methods: Sixty-one patients have been included in our study. The follow-up was 6 months. The patients were divided in two groups through a random draw (simple drainage and drainage associated with padding). All patients had a mastectomy with axillary dissection following the Madden technique. All quantities of lymphoceles during postoperative hospitalization and ambulatory care have been noted. Results: Twenty-five patients had benefited from the padding and 36 of a simple axillary drainage. Six months after the surgery, the patients benefitting from the padding had a quantity of lymphocele equal to half that of the control group (761.83 mL against 1373.60 mL; p = 0.01). During the postoperative hospitalization, the quantities were of 362.80 mL for the padding group versus 630.83 mL; p Conclusion: The production of postoperative lymphocele is heterogenous, varying from one patient to another. Nevertheless, the padding of the mastectomy compartment and of the axillary cavity allows a noticeable reduction of the produced quantity and of the hospitalization period at the expense of more pain.

Founder mutations have been reported in BRCA1 and BCRA2 in different ethnic groups with inherited breast cancer. Testing of targeted mutations in specific populations is important for cancer prevention in mutation carriers. In Sub-Saharan Africa, only a few studies have reported specific founder mutations in inherited breast cancer. The pathogenic variant c.815_824dup of BRCA1 has been reported as the most frequent among African American populations with inherited breast cancer and was supposed to have a West African origin. Recent report from Senegal identified this variant in women with inherited breast cancer at the highest frequency ever reported. The variant was linked to a common haplotype confirming its founder effect in West Africa. In this article, we review the mutation history of c.815_824dup and discuss how it spread out of Africa through the transatlantic slave trade.

AIM: To study the therapeutic aspects of endometrial cancer at the Joliot Curie Institute in Dakar. MATERIALS AND METHODS: This is a retrospective study conducted at the Joliot Curie Institute in Dakar including all cases of endometrial cancer confirmed by histology between January 2012 and December 2016. RESULTS: There were 30 cases of endometrial cancer over a period of five years. Endometrioid adenocarcinoma was the most common type of histology and was found in 25 patients, or 84% of cases. The patients were classified as stages I and II of FIGO in 43% of cases, stage III in 24% of cases and stage IV in 33% of cases. Colpo-hysterectomy with pelvic lymphadenectomy (CHL) was the main surgical procedure performed. External radiotherapy was performed in three patients or 10%. A case of radiation cystitis and radiodermatitis were recorded as a radiotherapy complication. No patient received brachytherapy. Chemotherapy was performed in 17 patients, ie 56.6%. She was adjuvant in 10 patients, or 34% of cases. Pelvic recurrences were noted in three patients who underwent 10% surgery. After 13 months of follow-up, survival was 50%. CONCLUSION: The most effective treatment modality for endometrial cancer at the Joliot Curie Institute was surgery followed by chemotherapy and Radiation therapy.

A multidisciplinary Task Force of African oncologists and patient representatives published the Choosing Wisely Africa (CWA) recommendations in 2020. These top 10 recommendations identify low-value, unnecessary, or harmful practices that are frequently used in Sub-Saharan Africa (SSA). In this study, we describe agreement and concordance with the recommendations from front-line oncologists across SSA.An electronic survey was distributed to members of the African Organization for ResearchTraining in Cancer (AORTIC) and oncology groups within SSA using a hierarchical snowball method; each primary contact distributed the survey through their personal networks. The survey captured information about awareness of the CWA list, agreement with recommendations, and concordance with clinical practice. Descriptive statistics were used to summarize study results.52 individuals responded to the survey; 64% (33/52) were female and 58% (30/52) were clinical oncologists. Respondents represented 15 countries in SSA; 69% (36/52) practiced exclusively in the public system. Only 46% (24/52) were aware of the CWA list and 89% (46/52) agreed it would be helpful if the list was displayed in their clinic. There was generally a high agreement with the recommendations (range 84-98%); the highest agreement was related to staging/defining treatment intent (98%). The proportion of oncologists who implemented these recommendations in routine practice was somewhat lower (range 68-100%). Lowest rates of concordance related to: the use of shorter schedules of radiotherapy (67%); discussion of active surveillance forlow-risk prostate cancer (67%); only performing breast surgery for a mass that was proven to be malignant (70%); and seeking multidisciplinary input for curative intent treatment plans (73%).While most frontline SSA oncologists agree with CWA recommendations, efforts are needed to disseminate the list. Agreement with the recommendations is high but there are gaps in implementation in routine practice. Further work is needed to understand the barriers and enablers of implementation.

Background and Objectives: Cervical cancer is a leading cause of cancer death in female populations. It is a virally induced carcinoma resulting from sexually transmitted high risk Human Papillomavirus infections (e.g. HPV-16, HPV-18). Previous studies have shown associations between IL-17A levels in cancer micro-environments and metastasis of tumor cells. In Africa, chemotherapy (CT) is the standard first-line treatment for cervical cancer and the prognosis remains poor for metastatic and recurrent cases. The impact of CT as a treatment option is still unclear. We investigated the prognostic relevance of IL-17A profiles in Cervical cancer patients (CP) patients treated with cisplatin in combination with 5-fluouracil (5FU) for three cycles. Methods: The study included 57 CP and 59 women with no history of malignancy as healthy controls (HC). IL-17A plasma levels were evaluated by ELISA. For each CP, three blood samples were collected at three-week intervals before initiation of the chemotherapy protocol. Results: Before chemotherapy CP showed higher serum levels of IL-17A compared to HCs (p = 0.035). No relation was detected between age and IL-17A levels. We observed a significant increase in serum IL-17A during treatment of the CP group (p < 0.05). Depending on chemotherapy’s efficacy, CP were divided into 1) non responders, 2) partial responders and 3) good responders. Non-responders patients showed significantly higher serum levels of IL-17A during the follow-up compared to partial and good responder groups both following the first CT cycle (p < 0.05) and the second CT cycle (p < 0.03). Conclusion: Our results suggest that high serum levels of IL-17A are associated with poor responses to classical chemotherapy. However, considering these results to design CC biomarkers, we need further investigations particularly about the relevant prognostic indicator following chemotherapy.

e18835 Background: A multidisciplinary Task Force of African oncologists and patient representatives published the Choosing Wisely Africa (CWA) recommendations in 2020. These recommendations identified low-value, unnecessary, or harmful practices that are frequently used in Sub-Saharan Africa (SSA). We describe agreement and concordance with the recommendations from front-line oncologists across SSA. Methods: A self-administered electronic survey was distributed to members of the African Organization for Research & Training in Cancer and oncology groups within SSA using a hierarchical snowball method. The survey captured information about awareness of CWA, agreement with recommendations, and concordance with clinical practice. Descriptive statistics were used to summarize study results. Results: 49 individuals responded to the survey; 61% (30/49) were female and 59% (29/49) were clinical oncologists. Respondents represented 14 countries in SSA; 69% (34/49) practiced exclusively in the public system. Only 43% (21/49) were aware of the CWA list and 90% (44/49) agreed it would be helpful if the list was displayed in their clinic. There was generally high agreement (Table) with the recommendations (range 84-98%); highest agreement related to staging/defining treatment intent (98%). The proportion of oncologists who implemented these recommendations in routine practice was somewhat lower (range 68-100%). Lowest rates of concordance related to: use of shorter schedules of radiotherapy (68%). Conclusions: While most frontline SSA oncologists agree with CWA recommendations, efforts are needed to disseminate the list. Agreement with the recommendations is high but there are gaps in implementation in routine practice. Further work is required to understand barriers and enablers of implementation.[Table: see text]

Un myofibroblastome de type mammaire est une tumeur molle rare; les myofibroblastomes extramammaires sont particulièrement rare. Un homme de 78 ans s'est présenté en consultation pour des douleurs pelviennes soulagées par la défécation ou les urines. Le toucher rectal retrouve une masse en avant de la paroi rectale antérieure. L'imagerie par résonance magnétique (IRM) montre une masse de 10 x 6 x 8cm, bien circonscrite et hétérogène, située en arrière de la vessie qu'elle refoule vers l'avant, en avant du recto-sigmoïde. L'immunohistochimie montre des cellules tumorales co-exprimant CD34 et la desmine de façon diffuse, expression de Rb dans la majorité des cellules, expression des récepteurs aux œstrogènes, expression intense et diffuse de la P16, un index de prolifération avec le ki67 estimé à 25%. Il n'y a pas eu de récidive après 8 mois de radiothérapie d'induction suivie de chirurgie. Un myofibroblastome de type mammaire est une tumeur rare et bénigne. La récidive n'est quasiment pas observée après traitement local. Ce cas permet de mettre en avance la possibilité d'utiliser la radiothérapie afin de faciliter la chirurgie.

Un myofibroblastome de type mammaire est une tumeur molle rare; les myofibroblastomes extramammaires sont particulièrement rare. Un homme de 78 ans s'est présenté en consultation pour des douleurs pelviennes soulagées par la défécation ou les urines. Le toucher rectal retrouve une masse en avant de la paroi rectale antérieure. L'imagerie par résonance magnétique (IRM) montre une masse de 10 x 6 x 8cm, bien circonscrite et hétérogène, située en arrière de la vessie qu'elle refoule vers l'avant, en avant du recto-sigmoïde. L'immunohistochimie montre des cellules tumorales co-exprimant CD34 et la desmine de façon diffuse, expression de Rb dans la majorité des cellules, expression des récepteurs aux œstrogènes, expression intense et diffuse de la P16, un index de prolifération avec le ki67 estimé à 25%. Il n'y a pas eu de récidive après 8 mois de radiothérapie d'induction suivie de chirurgie. Un myofibroblastome de type mammaire est une tumeur rare et bénigne. La récidive n'est quasiment pas observée après traitement local. Ce cas permet de mettre en avance la possibilité d'utiliser la radiothérapie afin de faciliter la chirurgie.

Background Cases of cervical cancer are increasing steadily in sub-Saharan Africa, with over 75,000 new cases and nearly 50,000 deaths a year (Mboumba et al., 2017). In Senegal, pathologies such as cervical cancer are one of the top causes of death and the Human papillomavirus (HPV) is its aetiological agent (Steenbergen et al., 2005). Methods The aim of the study is to analyse the distribution of HPV among Senegalese women with cervical cancer. The main objective of this study is to identify the HPV types associated or “co-associated” with cervical oncogenesis in Senegal. The association with the risk factors of cervin carcinogenesis were analysed as well. Cervical biopsies were performed on the women admitted to Aristide Hospital Le Dantec-Julio Curie Institute. Three methods were used to detect HPV genotypes: SANGER sequencing genotyping (Applied BioSystems), PCR real-time approach technique (HPV 16 & 18 RealTime PCR kit) (www.bioneer.co.kr) and the genotyping approach from Chippron (HPV kit 3.5 LCDArray) (info@chipron.com).Results In this study, 24.16% of monoinfections and 75.83% of multiple infections (co-infections) were noted and the majority were at high risk (HR-HPV types). It appears that the HPV genotypes 16, 18 and 45 are the most found in tumors. The most common types of HPV in our study were HPV 16 (100%), 18 (83%), 45 (33%), 33 (31%), 59 (28%), 35 (12%), 31 (11%), 58 (8%), 39 and 73 (4%), 44, 54 and 68 (3%). In the Dakar region, which had the highest number of cases, a prevalence of 17.89% of HR-HPV co-infections was found and the majority of our patients were on a polygamous diet. Polygamy could therefore be a cofactor in the occurrence of cervical cancer in Senegalese women.Conclusion Polygamy could represent a cofactor in the occurrence of cervical cancer in Senegalese women. No association was found between high-risk HPV co-infections and cancer stages. However, an increase of our cohort would be necessary to affirm these hypotheses.

En 2 ans de pandémie, la science est toujours interpellée en priorité pour répondre au défi de la Covid-19. La vaccination tant attendue a apporté son lot d’espoir et montré ses limites qui ne tiennent pas tant de son efficacité que de déterminants socio-culturels et politiques. Notre capacité de résilience quoique mise à rude épreuve nous a permis de maintenir les bases de notre cohésion sociale et professionnelle. Et c’est dans ce contexte que nous organisons pour la 2ème fois en plein Covid-19, le congrès SOSECAN 2021. Forts de notre capacité d’adaptation et de notre expérience de la SOSECAN 2020 et forcés de nous battre contre le cancer dans ce tumulte infectieux, nous avons organisé ce congrès en semi-présentiel en respectant les mesures édictées par l’autorité. L’innovation de cette année vient d’outre-manche avec l’organisation parallèle de l’ISUOG qui lutte contre les cancers gynécologiques. Nous espérons vous voir nombreux assister à ce congrès et remercions les autorités académiques et les partenaires de l’industrie pharmaceutique pour leur implication. Bienvenue à tous ! Dr Sidy Ka, Professeur Assimilé Président du comité d’organisation

Introductionnon-puerperal uterine inversions are a rare situation. Indeed, 85% of uterine inversions are puerperal. We report 2 cases observed at the Joliot Curie Institute of the Aristide Le Dantec University Hospital.Case PresentationIt was about a 39-year-old primigravida and a 47-year-old seventh gestational patient, who had a stage 4 of uterine inversion picture in relation to uterine sarcoma and uterine myoma respectively. The diagnosis was suspected at the clinic due to the absence of palpation of the uterus. Confirmation was made on medical imaging and intraoperatively. Management was radical with a total hysterectomy with bilateral adnexectomy via the vaginal and abdominal routes. However, in the first patient with sarcoma, surgery combined bilateral pelvic lymphadenectomy and was preceded by chemotherapy.Conclusionnon-puerperal uterine inversion is a rare situation. Its treatment is essentially surgical. However, it is important to look for an etiology and in the case of a tumor to ensure that the mass is a cancer or not because the management and prognosis depend on it.

PURPOSE Choosing Wisely Africa (CWA) builds on Choosing Wisely (CW) in the United States, Canada, and India and aims to identify low-value, unnecessary, or harmful cancer practices that are frequently used on the African continent. The aim of this work was to use physicians and patient advocates to identify a short list of low-value practices that are frequently used in African low- and middle-income countries. METHODS The CWA Task Force was convened by the African Organization for Research and Training in Cancer and included representatives from surgical, medical, and radiation oncology, the private and public sectors, and patient advocacy groups. Consensus was built through a modified Delphi process, shortening a long list of practices to a short list, and then to a final list. A voting threshold of ≥ 60% was used to include an individual practice on the short list. A consensus was reached after a series of teleconferences and voting processes. RESULTS Of the 10 practices on the final list, one is a new suggestion and 9 are revisions or adaptations of practices from previous CW campaign lists. One item relates to palliative care, 8 concern treatment, and one relates to surveillance. CONCLUSION The CWA initiative has identified 10 low-value, common interventions in Africa’s cancer practice. The success of this campaign will be measured by how the recommendations are implemented across sub-Saharan Africa and whether this improves the delivery of high-quality cancer care.

X-ray repair cross complementing 1 and 3 (XRCC1 and XRCC3) gene plays a key role in DNA repair, genetic instability and tumorigenesis.We hypothesized that single nucleotide polymorphisms (SNPs) in XRCC1 and XRCC3 gene might affect its expression and/or function which have an influence on the development of cervical cancer. The aim of our study was to assess the association of four polymorphisms was carried out in the following DNA repair genes: XRCC1 (Arg399Gln, Arg194Trp) (rs25487, rs1799782), XRCC3 (C241T and A316G) (rs861539, rs1799794). The study group included 505 Senegalese individuals (313 cervical cancer patients, and 192 healthy controls). From the cancer patients and controls, genomic DNA was extracted from blood and tissues samples. Genotype was carried out for four SNPs using Taqman genotyping assay method.A significant association was found between XRCC1194C>T and cervical cancer (OR= 2.696 95% CI= 1.181-6.154 p= 0.018, using an additive model), (OR=2.989 95% CI= 1.078-8.283 p= 0.035, using dominant model), while there is no significant association between Arg399Gln polymorphisms and cervical cancer. Also, no association was found between XRCC3Thr241Met genotype and expressed risk of susceptibility to both cervical cancer in Senegalese population.This study indicates that variant types of DNA repair genes play an important role in modifying individual susceptibility to cervical cancer. &nbsp

Background Cases of cervical cancer are increasing steadily in sub-Saharan Africa, with over 75,000 new cases and nearly 50,000 deaths a year (Mboumba et al., 2017). In Senegal, pathologies such as cervical cancer are one of the top causes of death and the Human papillomavirus (HPV) is its aetiological agent (Steenbergen et al., 2005). Methods The aim of the study is to analyse the distribution of HPV among Senegalese women with cervical cancer. The main objective of this study is to identify the HPV types associated or “co-associated” with cervical oncogenesis in Senegal. The correlations with the risk factors of cervin carcinogenesis were analysed as well. Cervical biopsies were performed on the women admitted to Aristide Hospital Le Dantec-Julio Curie Institute. Three methods were used to detect HPV genotypes: SANGER sequencing genotyping (Applied BioSystems), PCR real-time approach technique (HPV 16 & 18 RealTime PCR kit) (www.bioneer.co.kr) and the genotyping approach from Chippron (HPV kit 3.5 LCDArray) (info@chipron.com). Results In this study, the sample had multiple infections (co-infections), and a majority of the coinfections were high-risk types (HR-HPV types). The most common type of HPV in our study were 16 (34.37%), 18 (23.29%), 45 (10.75%), 33 (9.94%), 59 (9.09%), (3.97%) and 31 (3.69%). Among the co-infections detected in different regions of Senegal in women with cervical cancer, we found that HPV types 16 and 18 had the highest prevalence. In the Dakar region, which had the highest number of cases, a prevalence of 17.89% of HR-HPV co-infections was found. Conclusion Polygamy could represent a cofactor in the occurrence of cervical cancer in Senegalese women. No association was found between high-risk HPV co-infections and cancer stages. However, an increase of our cohort would be necessary to affirm these hypotheses.