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3. Ab-Externo MicroShunt versus Trabeculectomy in Primary Open-Angle Glaucoma: Two-Year Results from a Randomized, Multicenter Study

Author

Vold, Steven, McFarland, Michael, Stiles, Michael, Stechschulte, Ann, Strom, Amanda, Reynolds, Adam, Noecker, Robert, Thimons, Joseph, Khaimi, Mahmoud, Allen, Evan, Sarkisian, Steve, Barnebey, Howard, Golez, Ernesto, Feldman, Robert, Bell, Nicholas, Blieden, Lauren, Cantor, Louis, WuDunn, Darrell, Catoira-Boyle, Yara, Chen, Huiyi, Evans, Joshua, Martin, Elizabeth, Sozeri, Yasemin, Srivastava, Vinita, Wise, Ryan, Schwartz, Kenneth, Grover, Davinder, Butler, Michelle, Emanuel, Matthew, Fellman, Ronald, Godfrey, David, Smith, Oluwatosin, Kornmann, Helen, Khatana, Anup, Hagee, Daniel, Kuhlman, Brian, Zink, Jeffrey, Moster, Marlene, Dale, Elizabeth, Pro, Michael, Baker, Douglas, Chambers, Megan, Lehmann, David, Caprioli, Joseph, Francis, Brian, Giaconi, JoAnn, Law, Simon, Nouri-Mahdavi, Kouros, Coleman, Anne, Flynn, William, Rashid, Edward, Reilly, Charles, Rice, Robert, Sidoti, Paul, Panarelli, Joseph, Garg, Reena, Tania Tai, Tak Yee, Vinod, Kate, Harizman, Noga, Ritch, Robert, Reiss, George, Dewan, Vinay, Patel, Shamil, Sorenson, Christina, Larsen, Christine, Samuelson, Thomas, Hansen, Mark, Barth, Tara, Blakstad, Alyson, Buboltz, Mark, Fahmy, Ahmad, Fahmy, Mona, Montealegre, Kate, Mizener, Martin, Whitted, Peter, Lim, Michele, Brandt, James, Baik, Annie, Jiang, Angela, Brown, Steve V.L., Breunig, Adam C., Gorla, Madhu S.R., Riss, Isabelle, Feijoo, Garcia, Mendez Hernandez, Carmen, Martinez de la Casa, Jose, Dupré Pelaez, Mauro, Fernandez Vidal, Ana, García Sáenz, Sofia, Morales Fernandez, Laura, Sáenz Francés, Federico, Santos Bueso, Enrique, Perucho Gonzalez, Lucia, Beckers, Henny J.M., Kujovic, Stefani, Nardi, Marco, Maglionico, Maria N., Nasini, Francesco, Passani, Andrea, Strouthidis, Nick, Barton, Keith, Clarke, Jonathan, Gazzard, Gus, Jayaram, Hari, Khaw, Peng, Papadopoulos, Maria, Puertas, Renata, Toth, Marta, Lunt, David, Triolo, Giacinto, Kam, Ronald, Levine, Jason, Flowers, Brian, Nair, Unni, Simmons, Steven, Pokabla, Michael, Panarelli, Joseph F., Moster, Marlene R., Garcia-Feijoo, Julian, Flowers, Brian E., Baker, N. Douglas, Barnebey, Howard S., Grover, Davinder S., Khatana, Anup K., Lee, Bonny, Nguyen, Tuan, Stiles, Michael C., Sadruddin, Omar, and Khaw, Peng T.

Published
2024
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4. Visual Field Outcomes in the Primary Tube Versus Trabeculectomy Study

Author

Gedde, Steven, Banitt, Michael, Budenz, Donald, Chang, Ta, Lee, Richard, Palmberg, Paul, Parrish, Richard, II, Swaminathan, Swarup, Vazquez, Luis, Wellik, Sarah, Werner, Mark, Zink, Jeffrey, Khatana, Anup, Grover, Davinder, Neelakantan, Arvind, Barton, Keith, Panarelli, Joseph, Sidoti, Paul, Tsai, James, Vinod, Kateki, Goyal, Saurabh, Lind, John, Shields, Steven, Lim, Kin Sheng, Brandt, James, Sherwood, Mark, Khaimi, Mahmoud, Sankar, Prithvi, Ansari, Husam, Miller-Ellis, Eydie, Feldman, Robert, Baker, Laura, Bell, Nicholas, Ahmed, Iqbal, Williams, Donna, Prum, Bruce, Ramulu, Pradeep, Jampel, Henry, Feuer, William, Londono, Luz, Schiffman, Joyce, Shi, Wei, Silva, Yolanda, Vanner, Elizabeth, Chen, Philip, Heuer, Dale, Singh, Kuldev, Wright, Martha, Swaminathan, Swarup S., Jammal, Alessandro A., Medeiros, Felipe A., and Gedde, Steven J.

Published
2024
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6. Outcomes of Glaucoma Reoperations in the Primary Tube Versus Trabeculectomy Study

Author

Coulon, Sara J., Vanner, Elizabeth A., Gedde, Steven J., Banitt, Michael, Budenz, Donald, Lee, Richard, Palmberg, Paul, Parrish, Richard, II, Vazquez, Luis, Wellik, Sarah, Werner, Mark, Zink, Jeffrey, Khatana, Anup, Grover, Davinder, Neelakantan, Arvind, Barton, Keith, Panarelli, Joseph, Sidoti, Paul, Tsai, James, Vinod, Kateki, Goyal, Saurabh, Lind, John, Shields, Steven, Lim, Kin Sheng, Brandt, James, Sherwood, Mark, Khaimi, Mahmoud, Sankar, Prithvi, Ansari, Husam, Miller-Ellis, Eydie, Feldman, Robert, Baker, Laura, Bell, Nicholas, Ahmed, Iqbal, Williams, Donna, Prum, Bruce, Ramulu, Pradeep, Jampel, Henry, Feuer, William, Londono, Luz, Schiffman, Joyce, Shi, Wei, Silva, Yolanda, Vanner, Elizabeth, Chen, Philip, Heuer, Dale, Singh, Kuldev, and Wright, Martha

Published
2023
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7. The African Descent and Glaucoma Evaluation Study (ADAGES) III Contribution of Genotype to Glaucoma Phenotype in African Americans: Study Design and Baseline Data

Author

Zangwill, Linda M, Ayyagari, Radha, Liebmann, Jeffrey M, Girkin, Christopher A, Feldman, Robert, Dubiner, Harvey, Dirkes, Keri A, Holmann, Matthew, Williams-Steppe, Eunice, Hammel, Naama, Saunders, Luke J, Vega, Suzanne, Sandow, Kevin, Roll, Kathryn, Slight, Rigby, Auerbach, Daniel, Samuels, Brian C, Panarelli, Joseph F, Mitchell, John P, Al-Aswad, A, Park, Sung Chul, Tello, Celso, Cotliar, Jeremy, Bansal, Rajendra, Sidoti, Paul A, Cioffi, George A, Blumberg, Dana, Ritch, Robert, Bell, Nicholas P, Blieden, Lauren S, Davis, Garvin, Medeiros, Felipe A, Ng, Maggie CY, Das, Swapan K, Palmer, Nicholette D, Divers, Jasmin, Langefeld, Carl D, Freedman, Barry I, Bowden, Donald W, Christopher, Mark A, Chen, Yii-der I, Guo, Xiuqing, Taylor, Kent D, Rotter, Jerome I, Weinreb, Robert N, and Group, African Descent and Glaucoma Evaluation Study III Genomics Study

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Neurosciences, Aging, Neurodegenerative, Clinical Research, Eye Disease and Disorders of Vision, Eye, Black or African American, Aged, Body Constitution, Case-Control Studies, Cross-Sectional Studies, Female, Gene-Environment Interaction, Genome-Wide Association Study, Genotype, Glaucoma, Open-Angle, Humans, Intraocular Pressure, Male, Middle Aged, Phenotype, Polymorphism, Single Nucleotide, Research Design, Visual Acuity, Visual Fields, White People, African Descent and Glaucoma Evaluation Study III Genomics Study Group, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry, Ophthalmology and optometry
Abstract

PurposeTo describe the study protocol and baseline characteristics of the African Descent and Glaucoma Evaluation Study (ADAGES) III.DesignCross-sectional, case-control study.ParticipantsThree thousand two hundred sixty-six glaucoma patients and control participants without glaucoma of African or European descent were recruited from 5 study centers in different regions of the United States.MethodsIndividuals of African descent (AD) and European descent (ED) with primary open-angle glaucoma (POAG) and control participants completed a detailed demographic and medical history interview. Standardized height, weight, and blood pressure measurements were obtained. Saliva and blood samples to provide serum, plasma, DNA, and RNA were collected for standardized processing. Visual fields, stereoscopic disc photographs, and details of the ophthalmic examination were obtained and transferred to the University of California, San Diego, Data Coordinating Center for standardized processing and quality review.Main outcome measuresParticipant gender, age, race, body mass index, blood pressure, history of smoking and alcohol use in POAG patients and control participants were described. Ophthalmic measures included intraocular pressure, visual field mean deviation, central corneal thickness, glaucoma medication use, or past glaucoma surgery. Ocular conditions, including diabetic retinopathy, age-related macular degeneration, and past cataract surgery, were recorded.ResultsThe 3266 ADAGES III study participants in this report include 2146 AD POAG patients, 695 ED POAG patients, 198 AD control participants, and 227 ED control participants. The AD POAG patients and control participants were significantly younger (both, 67.4 years) than ED POAG patients and control participants (73.4 and 70.2 years, respectively). After adjusting for age, AD POAG patients had different phenotypic characteristics compared with ED POAG patients, including higher intraocular pressure, worse visual acuity and visual field mean deviation, and thinner corneas (all P < 0.001). Family history of glaucoma did not differ between AD and ED POAG patients.ConclusionsWith its large sample size, extensive specimen collection, and deep phenotyping of AD and ED glaucoma patients and control participants from different regions in the United States, the ADAGES III genomics study will address gaps in our knowledge of the genetics of POAG in this high-risk population.

Published
2019

8. Genetic Architecture of Primary Open-Angle Glaucoma in Individuals of African Descent The African Descent and Glaucoma Evaluation Study III

Author

Taylor, Kent D, Guo, Xiuqing, Zangwill, Linda M, Liebmann, Jeffrey M, Girkin, Christopher A, Feldman, Robert M, Dubiner, Harvey, Hai, Yang, Samuels, Brian C, Panarelli, Joseph F, Mitchell, John P, Al-Aswad, A, Park, Sung Chul, Tello, Celso, Cotliar, Jeremy, Bansal, Rajendra, Sidoti, Paul A, Cioffi, George A, Blumberg, Dana, Ritch, Robert, Bell, Nicholas P, Blieden, Lauren S, Davis, Garvin, Medeiros, Felipe A, Das, Swapan K, Divers, Jasmin, Langefeld, Carl D, Palmer, Nicholette D, Freedman, Barry I, Bowden, Donald W, Ng, Maggie CY, Chen, Yii-Der Ida, Ayyagari, Radha, Rotter, Jerome I, Weinreb, Robert N, and Group, African Descent and Glaucoma Evaluation Study III Genomics Study

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Neurosciences, Eye Disease and Disorders of Vision, Prevention, Genetics, Aging, Neurodegenerative, Human Genome, Black or African American, Aged, Case-Control Studies, Cross-Sectional Studies, Female, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Glaucoma, Open-Angle, Humans, Intraocular Pressure, Male, Middle Aged, Phosphopyruvate Hydratase, Polymorphism, Single Nucleotide, ROC Curve, African Descent and Glaucoma Evaluation Study III Genomics Study Group, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry, Ophthalmology and optometry
Abstract

PurposeTo find genetic contributions to glaucoma in African Americans.DesignCross-sectional, case-control study.ParticipantsOne thousand eight hundred seventy-five primary open-angle glaucoma (POAG) patients and 1709 controls, self-identified as being of African descent (AD), from the African Descent and Glaucoma Evaluation Study (ADAGES) III and Wake Forest School of Medicine.MethodsMegaChip genotypes were imputed to Thousand Genomes data. Association of single nucleotide polymorphisms (SNPs) with POAG and advanced POAG was tested by linear mixed model correcting for relatedness and population stratification. Genetic risk scores were tested by receiver operator characteristic curves (ROC-AUCs).Main outcome measuresPrimary open-angle glaucoma defined by visual field loss without other nonocular conditions (n = 1875). Advanced POAG was defined by age-based mean deviation of visual field (n = 946).ResultsEighteen million two hundred eighty-one thousand nine hundred twenty SNPs met imputation quality of r2 > 0.7 and minor allele frequency > 0.005. Association of a novel locus, EN04, was observed for advanced POAG (rs185815146 β, 0.36; standard error, 0.065; P < 3×10-8). For POAG, an AD signal was observed at the 9p21 European descent (ED) POAG signal (rs79721419; P < 6.5×10-5) independent of the previously observed 9p21 ED signal (rs2383204; P < 2.3×10-5) by conditional analyses. An association with POAG in FNDC3B (rs111698934; P < 3.9×10-5) was observed, not in linkage disequilibrium (LD) with the previously reported ED SNP. Additional previously identified loci associated with POAG in persons of AD were: 8q22, AFAP1, and TMC01. An AUC of 0.62 was observed with an unweighted genetic risk score comprising 11 SNPs in candidate genes. Two additional risk scores were studied by using a penalized matrix decomposition with cross-validation; risk scores of 50 and 400 SNPs were identified with ROC of AUC = 0.74 and AUC = 0.94, respectively.ConclusionsA novel association with advanced POAG in the EN04 locus was identified putatively in persons of AD. In addition to this finding, this genome-wide association study in POAG patients of AD contributes to POAG genetics by identification of novel signals in prior loci (9p21), as well as advancing the fine mapping of regions because of shorter average LD (FNDC3B). Although not useful without confirmation and clinical trials, the use of genetic risk scores demonstrated that considerable AD-specific genetic information remains in these data.

Published
2019

11. Diagnostic Capability of OCTA-Derived Macular Biomarkers for Early to Moderate Primary Open Angle Glaucoma.

Author

Verticchio Vercellin, Alice, Harris, Alon, Oddone, Francesco, Carnevale, Carmela, Siesky, Brent A., Arciero, Julia, Fry, Brendan, Eckert, George, Sidoti, Paul A., Antman, Gal, Alabi, Denise, Coleman-Belin, Janet C., and Pasquale, Louis R.

Subjects
RECEIVER operating characteristic curves, OPTICAL coherence tomography, OPEN-angle glaucoma, NERVE fibers, OPTICAL control
Abstract

Background/Objectives: To investigate macular vascular biomarkers for the detection of primary open-angle glaucoma (POAG). Methods: A total of 56 POAG patients and 94 non-glaucomatous controls underwent optical coherence tomography angiography (OCTA) assessment of macular vessel density (VD) in the superficial (SCP), and deep (DCP) capillary plexus, foveal avascular zone (FAZ) area, perimeter, VD, choriocapillaris and outer retina flow area. POAG patients were classified for severity based on the Glaucoma Staging System 2 of Brusini. ANCOVA comparisons adjusted for age, sex, race, hypertension, diabetes, and areas under the receiver operating characteristic curves (AUCs) for POAG/control differentiation were compared using the DeLong method. Results: Global, hemispheric, and quadrant SCP VD was significantly lower in POAG patients in the whole image, parafovea, and perifovea (p < 0.001). No significant differences were found between POAG and controls for DCP VD, FAZ parameters, and the retinal and choriocapillaris flow area (p > 0.05). SCP VD in the whole image and perifovea were significantly lower in POAG patients in stage 2 than stage 0 (p < 0.001). The AUCs of SCP VD in the whole image (0.86) and perifovea (0.84) were significantly higher than the AUCs of all DCP VD (p < 0.05), FAZ parameters (p < 0.001), and retinal (p < 0.001) and choriocapillaris flow areas (p < 0.05). Whole image SCP VD was similar to the AUC of the global retinal nerve fiber layer (RNFL) (AUC = 0.89, p = 0.53) and ganglion cell complex (GCC) thickness (AUC = 0.83, p = 0.42). Conclusions: SCP VD is lower with increasing functional damage in POAG patients. The AUC for SCP VD was similar to RNFL and GCC using clinical diagnosis as the reference standard. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Glaucoma Treatment Outcomes in Open Angle Glaucoma Patients of African Descent

Author

Siesky, Brent, Harris, Alon, Belamkar, Aditya, Zukerman, Ryan, Horn, Avery, Vercellin, Alice Verticchio, Mendoza, Kristen Ann V., Sidoti, Paul A., and Oddone, Francesco

Subjects
Ophthalmology, Treatment Outcome, Humans, Glaucoma, Trabeculectomy, Prospective Studies, Article, Glaucoma, Open-Angle, Intraocular Pressure
Abstract

Open angle glaucoma (OAG), characterized by structural changes to the optic nerve head and retinal nerve fiber layer, is a progressive multifactorial optic neuropathy and a leading cause of irreversible blindness globally. Currently, intraocular pressure is the only modifiable risk factor; however, others have been identified, including genetics and race. Importantly, OAG is much more prevalent in persons of African descent (AD) compared with those of European descent (ED). OAG patients of AD are also known to have a more severe course of the disease, a finding potentially explained by structural and/or vascular differences within eye tissues. In addition, disparities in treatment outcomes have been identified in OAG patients of AD. Specifically, prostaglandin analogues have been suggested to be more effective in patients of AD than in those ED, while beta-adrenergic receptors have been suggested to be less effective, although the evidence is inconsistent. AD has also been identified as a risk factor for trabeculectomy failure while laser trabeculoplasty has been conversely found to be very effective in lowering intraocular pressure in patients of AD. Alternative surgical options, including Ex-Press shunt implantation, viscocanalostomy, and canaloplasty are promising in equivalence but require further research to evaluate disparity in outcome properly. In addition to treatment outcomes, social disparities affecting clinical care also exist for AD persons in the form of reduced adherence, access, and choice. Overall, data suggest the need for properly designed prospective trials with AD populations as a primary focus to identify the potential mechanisms driving disparities in treatment and address overall potential bias in glaucoma management.

Published
2022

22. Postoperative Complications in the Primary Tube Versus Trabeculectomy Study During 5 Years of Follow-up

Author

Gedde, Steven J., primary, Feuer, William J., additional, Lim, Kin Sheng, additional, Barton, Keith, additional, Goyal, Saurabh, additional, Ahmed, Iqbal I., additional, Brandt, James D., additional, Banitt, Michael, additional, Budenz, Donald, additional, Lee, Richard, additional, Palmberg, Paul, additional, Parrish, Richard, additional, Vazquez, Luis, additional, Wellik, Sarah, additional, Werner, Mark, additional, Zink, Jeffrey, additional, Khatana, Anup, additional, Grover, Davinder, additional, Neelakantan, Arvind, additional, Panarelli, Joseph, additional, Sidoti, Paul, additional, Tsai, James, additional, Vinod, Kateki, additional, Lind, John, additional, Shields, Steven, additional, Sherwood, Mark, additional, Khaimi, Mahmoud, additional, Sankar, Prithvi, additional, Ansari, Husam, additional, Miller-Ellis, Eydie, additional, Feldman, Robert, additional, Baker, Laura, additional, Bell, Nicholas, additional, Williams, Donna, additional, Prum, Bruce, additional, Ramulu, Pradeep, additional, Jampel, Henry, additional, Londono, Luz, additional, Schiffman, Joyce, additional, Shi, Wei, additional, Silva, Yolanda, additional, Vanner, Elizabeth, additional, Chen, Philip, additional, Heuer, Dale, additional, Singh, Kuldev, additional, and Wright, Martha, additional

Published
2022
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23. Treatment Outcomes in the Primary Tube Versus Trabeculectomy Study after 5 Years of Follow-up

Author

Gedde, Steven J., primary, Feuer, William J., additional, Lim, Kin Sheng, additional, Barton, Keith, additional, Goyal, Saurabh, additional, Ahmed, Iqbal I., additional, Brandt, James D., additional, Banitt, Michael, additional, Budenz, Donald, additional, Lee, Richard, additional, Palmberg, Paul, additional, Parrish, Richard, additional, Vazquez, Luis, additional, Wellik, Sarah, additional, Werner, Mark, additional, Zink, Jeffrey, additional, Khatana, Anup, additional, Grover, Davinder, additional, Neelakantan, Arvind, additional, Panarelli, Joseph, additional, Sidoti, Paul, additional, Tsai, James, additional, Vinod, Kateki, additional, Lind, John, additional, Shields, Steven, additional, Sherwood, Mark, additional, Khaimi, Mahmoud, additional, Sankar, Prithvi, additional, Ansari, Husam, additional, Miller-Ellis, Eydie, additional, Feldman, Robert, additional, Baker, Laura, additional, Bell, Nicholas, additional, Williams, Donna, additional, Prum, Bruce, additional, Ramulu, Pradeep, additional, Jampel, Henry, additional, Londono, Luz, additional, Schiffman, Joyce, additional, Shi, Wei, additional, Silva, Yolanda, additional, Vanner, Elizabeth, additional, Chen, Philip, additional, Heuer, Dale, additional, Singh, Kuldev, additional, and Wright, Martha, additional

Published
2022
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35. The African Descent and Glaucoma Evaluation Study (ADAGES) III: Contribution of Genotype to Glaucoma Phenotype in African Americans: Study Design and Baseline Data.

Author

Liebmann, Jeffrey, Liebmann, Jeffrey, Girkin, Christopher, Feldman, Robert, Dubiner, Harvey, Dirkes, Keri, Holmann, Matthew, Williams-Steppe, Eunice, Hammel, Naama, Saunders, Luke, Vega, Suzanne, Sandow, Kevin, Roll, Kathryn, Slight, Rigby, Auerbach, Daniel, Samuels, Brian, Panarelli, Joseph, Mitchell, John, Al-Aswad, Lama, Park, Sung, Tello, Celso, Cotliar, Jeremy, Bansal, Rajendra, Sidoti, Paul, Cioffi, George, Blumberg, Dana, Ritch, Robert, Bell, Nicholas, Blieden, Lauren, Davis, Garvin, Medeiros, Felipe, Ng, Maggie, Das, Swapan, Palmer, Nicholette, Divers, Jasmin, Langefeld, Carl, Freedman, Barry, Bowden, Donald, Christopher, Mark, Chen, Yii-der, Guo, Xiuqing, Taylor, Kent, Rotter, Jerome, Ayyagari, Radha, Weinreb, Robert, Zangwill, Linda, Liebmann, Jeffrey, Liebmann, Jeffrey, Girkin, Christopher, Feldman, Robert, Dubiner, Harvey, Dirkes, Keri, Holmann, Matthew, Williams-Steppe, Eunice, Hammel, Naama, Saunders, Luke, Vega, Suzanne, Sandow, Kevin, Roll, Kathryn, Slight, Rigby, Auerbach, Daniel, Samuels, Brian, Panarelli, Joseph, Mitchell, John, Al-Aswad, Lama, Park, Sung, Tello, Celso, Cotliar, Jeremy, Bansal, Rajendra, Sidoti, Paul, Cioffi, George, Blumberg, Dana, Ritch, Robert, Bell, Nicholas, Blieden, Lauren, Davis, Garvin, Medeiros, Felipe, Ng, Maggie, Das, Swapan, Palmer, Nicholette, Divers, Jasmin, Langefeld, Carl, Freedman, Barry, Bowden, Donald, Christopher, Mark, Chen, Yii-der, Guo, Xiuqing, Taylor, Kent, Rotter, Jerome, Ayyagari, Radha, Weinreb, Robert, and Zangwill, Linda

Abstract

PURPOSE: To describe the study protocol and baseline characteristics of the African Descent and Glaucoma Evaluation Study (ADAGES) III. DESIGN: Cross-sectional, case-control study. PARTICIPANTS: Three thousand two hundred sixty-six glaucoma patients and control participants without glaucoma of African or European descent were recruited from 5 study centers in different regions of the United States. METHODS: Individuals of African descent (AD) and European descent (ED) with primary open-angle glaucoma (POAG) and control participants completed a detailed demographic and medical history interview. Standardized height, weight, and blood pressure measurements were obtained. Saliva and blood samples to provide serum, plasma, DNA, and RNA were collected for standardized processing. Visual fields, stereoscopic disc photographs, and details of the ophthalmic examination were obtained and transferred to the University of California, San Diego, Data Coordinating Center for standardized processing and quality review. MAIN OUTCOME MEASURES: Participant gender, age, race, body mass index, blood pressure, history of smoking and alcohol use in POAG patients and control participants were described. Ophthalmic measures included intraocular pressure, visual field mean deviation, central corneal thickness, glaucoma medication use, or past glaucoma surgery. Ocular conditions, including diabetic retinopathy, age-related macular degeneration, and past cataract surgery, were recorded. RESULTS: The 3266 ADAGES III study participants in this report include 2146 AD POAG patients, 695 ED POAG patients, 198 AD control participants, and 227 ED control participants. The AD POAG patients and control participants were significantly younger (both, 67.4 years) than ED POAG patients and control participants (73.4 and 70.2 years, respectively). After adjusting for age, AD POAG patients had different phenotypic characteristics compared with ED POAG patients, including higher intraocular pressure, worse

Published
2019

36. Genetic Architecture of Primary Open Angle Glaucoma in Individuals of African Descent: The African Descent & Glaucoma Evaluation Study (ADAGES) III

Author

Taylor, Kent D., Guo, Xiuqing, Zangwill, Linda M., Liebmann, Jeffrey M., Girkin, Christopher A., Feldman, Robert M., Dubiner, Harvey, Hai, Yang, Samuels, Brian C., Panarelli, Joseph F., Mitchell, John P., Al-Aswad, Lama A., Park, Sung Chul, Tello, Celso, Cotliar, Jeremy, Bansal, Rajendra, Sidoti, Paul A., Cioffi, George A., Blumberg, Dana, Ritch, Robert, Bell, Nicholas P., Blieden, Lauren S., Davis, Garvin, Medeiros, Felipe A., Das, Swapan K., Divers, Jasmin, Langefeld, Carl D., Palmer, Nicholette D., Freedman, Barry I., Bowden, Donald W., Ng, Maggie C. Y., Chen, Yii-Der Ida, Ayyagari, Radha, Rotter, Jerome I., and Weinreb, Robert N.

Subjects
Male, genetic structures, Genotype, Middle Aged, Polymorphism, Single Nucleotide, eye diseases, Article, Black or African American, Cross-Sectional Studies, Gene Frequency, ROC Curve, Case-Control Studies, Phosphopyruvate Hydratase, Humans, Female, Genetic Predisposition to Disease, Glaucoma, Open-Angle, Intraocular Pressure, Aged, Genome-Wide Association Study
Abstract

OBJECTIVE: Find genetic contributions to glaucoma in African Americans. DESIGN: Cross-sectional, case-control study. PARTICIPANTS: 1875 POAG cases and 1709 controls, self-identified as African Descent (AD), from the African Descent and Glaucoma Evaluation Study (ADAGESIII) and Wake Forest School of Medicine. METHODS: MegaChip genotypes were imputed to Thousand Genomes data. Association of SNPs with POAG and advanced POAG was tested by linear mixed model correcting for relatedness and population stratification. Genetic risk scores were tested by Receiver Operator Characteristics (ROC-AUC). MAIN OUTCOME: POAG defined by visual field loss without other non-ocular conditions (N=1875). Advanced POAG was defined by age-based mean deviation of visual field (N=946). RESULTS: 18,281,920 SNPs met imputation quality r2>0.7 and minor allele frequency>0.005. Association of a novel locus, ENO4, was observed for advanced POAG (rs185815146 beta 0.36, SE 0.065, p

Published
2018

42. Optical Coherence Tomography Angiography Analysis of Perfused Peripapillary Capillaries in Primary Open-Angle Glaucoma and Normal-Tension Glaucoma

Author

Scripsema, Nicole K., primary, Garcia, Patricia M., additional, Bavier, Richard D., additional, Chui, Toco Y. P., additional, Krawitz, Brian D., additional, Mo, Shelley, additional, Agemy, Steven A., additional, Xu, Luna, additional, Lin, Yijie B., additional, Panarelli, Joseph F., additional, Sidoti, Paul A., additional, Tsai, James C., additional, and Rosen, Richard B., additional

Published
2016
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46. Meeting covers update on glaucoma drainage devices

Author

Sidoti, Paul A. and Ritch, Robert

Subjects
Health
Abstract

New data, technical innovations presented for complicated cases Editor's Introduction: New clinical data and several technical innovations regarding the use of glaucoma drainage devices for the treatment of complicated glaucomas [...]

Published
1998

49. Ocular decompression retinopathy: A review

Author

Mukkamala, Sri Krishna, primary, Patel, Amar, additional, Dorairaj, Syril, additional, McGlynn, Robert, additional, Sidoti, Paul A., additional, Weinreb, Robert N., additional, Rusoff, Jade, additional, Rao, Sunil, additional, and Gentile, Ronald C., additional

Published
2013
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