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• Disease prediction based on different user symptoms is done. • Different machine learning-based approaches are designed and employed for different tasks. • Utilizes sensors to measure corresponding symptoms, the study combines the IoT and cutting-edge deep learning models to yield an optimal result. • Microservice-based user interface is designed. COVID-19 disrupted lives and livelihoods and affected various sectors of the economy. One such domain was the already overburdened healthcare sector, which faced fresh challenges as the number of patients rose exponentially and became difficult to deal with. In such a scenario, telemedicine, teleconsultation, and virtual consultation became increasingly common to comply with social distancing norms. To overcome this pressing need of increasing 'remote' consultations in the 'post-COVID' era, the Internet of Things (IoT) has the potential to play a pivotal role, and this present paper attempts to develop a novel system that implements the most efficient machine learning (ML) algorithm and takes input from the patients such as symptoms, audio recordings, available medical reports, and other histories of illnesses to accurately and holistically predict the disease that the patients are suffering from. A few of the symptoms, such as fever and low blood oxygen, can also be measured via sensors using Arduino and ESP8266. It then provides for the appropriate diagnosis and treatment of the disease based on its constantly updated database, which can be developed as an application-based or website-based platform. [Display omitted] [ABSTRACT FROM AUTHOR]