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9 results on '"Siciliano, Edy Angela"'

1. Correction: Santonocito et al. Astaxanthin-Loaded Stealth Lipid Nanoparticles (AST-SSLN) as Potential Carriers for the Treatment of Alzheimer’s Disease: Formulation Development and Optimization. Nanomaterials 2021, 11, 391

Author

Santonocito, Debora, primary, Raciti, Giuseppina, additional, Campisi, Agata, additional, Sposito, Giovanni, additional, Panico, Annamaria, additional, Siciliano, Edy Angela, additional, Sarpietro, Maria Grazia, additional, Damiani, Elisabetta, additional, and Puglia, Carmelo, additional

Published
2023
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5. Astaxanthin-Loaded Stealth Lipid Nanoparticles (AST-SSLN) as Potential Carriers for the Treatment of Alzheimer’s Disease: Formulation Development and Optimization

Author

Santonocito, Debora, primary, Raciti, Giuseppina, additional, Campisi, Agata, additional, Sposito, Giovanni, additional, Panico, Annamaria, additional, Siciliano, Edy Angela, additional, Sarpietro, Maria Grazia, additional, Damiani, Elisabetta, additional, and Puglia, Carmelo, additional

Published
2021
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9. Solid Lipid Nanoparticles Loading Idebenone Ester with Pyroglutamic Acid: In Vitro Antioxidant Activity and In Vivo Topical Efficacy.

Author

Montenegro, Lucia, Panico, Anna Maria, Santagati, Ludovica Maria, Siciliano, Edy Angela, Intagliata, Sebastiano, and Modica, Maria N.

Subjects
NANOPARTICLES, PYROGLUTAMIC acid, ANTIOXIDANTS, NEURODEGENERATION, PHYSICS experiments
Abstract

Idebenone (IDE), a strong antioxidant widely investigated for the treatment of neurodegenerative diseases and skin disorders, shows low oral and topical bioavailability due to its unfavorable physico-chemical properties. In this work, to improve IDE topical effectiveness, we explored a two-steps approach: (1) we synthesized an IDE ester (IDEPCA) with pyroglutamic acid, a molecule whose hydrating effects are well known; (2) we loaded IDEPCA into solid lipid nanocarriers (SLN). We evaluated in vitro antioxidant and anti-glycation activity and in vivo hydrating effects after topical application in human volunteers from gel vehicles of IDEPCA SLN in comparison to IDE SLN. All SLN showed good technological properties (mean particle size < 25 nm, polydispersity index < 0.300, good stability). The oxygen radical absorbance capacity assay showed that IDEPCA SLN and IDE SLN had similar antioxidant activity while IDEPCA SLN were more effective in the in vitro NO scavenging assay. Both IDEPCA and IDE SLN showed the same effectiveness in inhibiting the formation of advanced glycation end products. In vivo experiments pointed out a better hydrating effect of IDEPCA SLN in comparison to IDE SLN. These results suggest that the investigated approach could be a promising strategy to obtain topical formulations with increased hydrating effects. [ABSTRACT FROM AUTHOR]

Published
2019
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