1. Comparative study of fibrosis induced by Marlex®, Parietex Composite®, Vicryl® and Ultrapro® meshes1.
- Author
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Biondo-Simões MLP, Sichciopi AA, Ioshii SO, Robes RR, and Biondo-Simões R
- Subjects
- Abdominal Wall surgery, Animals, Collagen administration & dosage, Fibrosis etiology, Fibrosis pathology, Materials Testing, Models, Animal, Polyesters administration & dosage, Polyglactin 910 administration & dosage, Polypropylenes administration & dosage, Time Factors, Tissue Adhesions etiology, Tissue Adhesions pathology, Abdominal Wall pathology, Collagen adverse effects, Polyesters adverse effects, Polyglactin 910 adverse effects, Polypropylenes adverse effects, Surgical Mesh adverse effects
- Abstract
Purpose: To evaluate the fibrosis induced by four different meshes: Marlex®, Parietex Composite®, Vicryl® and Ultrapro®., Methods: Histological cutouts of abdominal wall were analyzed with polarized light 28 days after the meshes implants and colorized by picrosirius to identify the intensity of collagen types I and III, and their maturation index., Results: When the four groups were compared, the total collagen area analyzed was bigger in groups A and D, with no difference between them. The collagen type I density was bigger in group A, with an average of 9.62 ± 1.0, and smaller in group C, with an average of 3.86 ± 0.59. The collagen type III density was similar in groups A, B and C, and bigger in group D. The collagen maturation index was different in each of the four groups, bigger in group A with 0.87, group B with 0.66, group D with 0.57 and group C with 0.33 (p = 0.0000)., Conclusion: The most prominent fibrosis promotion in the given meshes was found on Marlex® (polypropylene mesh) and the Parietex Composite® (non-biodegradable polyester); the collagen maturation index was higher in the Marlex® mesh, followed by Ultrapro®, Parietex Composite® and Vicryl® meshes.
- Published
- 2018
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