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6. SNS Timing System

Author

oerter, B., Nelson, R., Shea, T., and Sibley, C.

Subjects
Computer Science - Hardware Architecture, B.m
Abstract

This poster describes the timing system being designed for Spallation Neutron Source being built at Oak Ridge National lab.

Published
2001

12. The Spallation Neutron Source accelerator system design

Author

Henderson, S., Abraham, W., Aleksandrov, A., Allen, C., Alonso, J., Anderson, D., Arenius, D., Arthur, T., Assadi, S., Ayers, J., Bach, P., Badea, V., Battle, R., Beebe-Wang, J., Bergmann, B., Bernardin, J., Bhatia, T., Billen, J., Birke, T., Bjorklund, E., Blaskiewicz, M., Blind, B., Blokland, W., Bookwalter, V., Borovina, D., Bowling, S., Bradley, J., Brantley, C., Brennan, J., Brodowski, J., Brown, S., Brown, R., Bruce, D., Bultman, N., Cameron, P., Campisi, I., Casagrande, F., Catalan-Lasheras, N., Champion, M., Chen, Z., Cheng, D., Cho, Y., Christensen, K., Chu, C., Cleaves, J., Connolly, R., Cote, T., Cousineau, S., Crandall, K., Creel, J., Crofford, M., Cull, P., Cutler, R., Dabney, R., Dalesio, L., Daly, E., Damm, R., Danilov, V., Davino, D., Davis, K., Dawson, C., Day, L., Deibele, C., Delayen, J., DeLong, J., Demello, A., DeVan, W., Digennaro, R., Dixon, K., Dodson, G., Doleans, M., Doolittle, L., Doss, J., Drury, M., Elliot, T., Ellis, S., Error, J., Fazekas, J., Fedotov, A., Feng, P., Fischer, J., Fox, W., Fuja, R., Funk, W., Galambos, J., Ganni, V., Garnett, R., Geng, X., Gentzlinger, R., Giannella, M., Gibson, P., Gillis, R., Gioia, J., Gordon, J., Gough, R., Greer, J., Gregory, W., Gribble, R., Grice, W., Gurd, D., Gurd, P., Guthrie, A., Hahn, H., Hardek, T., Hardekopf, R., Harrison, J., Hatfield, D., He, P., Hechler, M., Heistermann, F., Helus, S., Hiatt, T., Hicks, S., Hill, J., Hoff, L., Hoff, M., Hogan, J., Holding, M., Holik, P., Holmes, J., Holtkamp, N., Hovater, C., Howell, M., Hseuh, H., Huhn, A., Hunter, T., Ilg, T., Jackson, J., Jain, A., Jason, A., Jeon, D., Johnson, G., Jones, A., Joseph, S., Justice, A., Kang, Y., Kasemir, K., Keller, R., Kersevan, R., Kerstiens, D., Kesselman, M., Kim, S., Kneisel, P., Kravchuk, L., Kuneli, T., Kurennoy, S., Kustom, R., Kwon, S., Ladd, P., Lambiase, R., Lee, Y.Y., Leitner, M., Leung, K.-N., Lewis, S., Liaw, C., Lionberger, C., Lo, C.C., Long, C., Ludewig, H., Ludvig, J., Luft, P., Lynch, M., Ma, H., MacGill, R., Macha, K., Madre, B., Mahler, G., Mahoney, K., Maines, J., Mammosser, J., Mann, T., Marneris, I., Marroquin, P., Martineau, R., Matsumoto, K., McCarthy, M., McChesney, C., McGahern, W., McGehee, P., Meng, W., Merz, B., Meyer, R., Jr., Meyer, R., Sr., Miller, B., Mitchell, R., Mize, J., Monroy, M., Munro, J., Murdoch, G., Musson, J., Nath, S., Nelson, R., O׳Hara, J., Olsen, D., Oren, W., Oshatz, D., Owens, T., Pai, C., Papaphilippou, I., Patterson, N., Patterson, J., Pearson, C., Pelaia, T., Pieck, M., Piller, C., Plawski, T., Plum, M., Pogge, J., Power, J., Powers, T., Preble, J., Prokop, M., Pruyn, J., Purcell, D., Rank, J., Raparia, D., Ratti, A., Reass, W., Reece, K., Rees, D., Regan, A., Regis, M., Reijonen, J., Rej, D., Richards, D., Richied, D., Rode, C., Rodriguez, W., Rodriguez, M., Rohlev, A., Rose, C., Roseberry, T., Jr., Rowton, L., Roybal, W., Rust, K., Salazer, G., Sandberg, J., Saunders, J., Schenkel, T., Schneider, W., Schrage, D., Schubert, J., Severino, F., Shafer, R., Shea, T., Shishlo, A., Shoaee, H., Sibley, C., Sims, J., Smee, S., Smith, J., Smith, K., Spitz, R., Staples, J., Stein, P., Stettler, M., Stirbet, M., Stockli, M., Stone, W., Stout, D., Stovall, J., Strelo, W., Strong, H., Sundelin, R., Syversrud, D., Szajbler, M., Takeda, H., Tallerico, P., Tang, J., Tanke, E., Tepikian, S., Thomae, R., Thompson, D., Thomson, D., Thuot, M., Treml, C., Tsoupas, N., Tuozzolo, J., Tuzel, W., Vassioutchenko, A., Virostek, S., Wallig, J., Wanderer, P., Wang, Y., Wang, J.G., Wangler, T., Warren, D., Wei, J., Weiss, D., Welton, R., Weng, J., Weng, W-T., Wezensky, M., White, M., Whitlatch, T., Williams, D., Williams, E., Wilson, K., Wiseman, M., Wood, R., Wright, P., Wu, A., Ybarrolaza, N., Young, K., Young, L., Yourd, R., Zachoszcz, A., Zaltsman, A., Zhang, S., Zhang, W., Zhang, Y., and Zhukov, A.

Published
2014
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13. Poster Summaries

Author

Gucciardo, Sébastien, Wisniewski, Jean-Pierre, Mak, Lora, Durrant, Marcus, Rathbun, Elizabeth, Brewin, Nick, Suzuki, Akihiro, Akune, Mitsumi, Imagama, Yoshihiro, Osuki, Ken-ichi, Aoki, Toshio, Uchiumi, Toshiki, Abe, Mikiko, Chou, Minxia, Zhou, Junchu, Xie, Bo, Miao, Lihong, Zhou, Kui, Xie, Fuli, Cheng, Xian-Guo, Tajima, Shigeyuki, Kouchi, Hiroshi, Wang, Yanzhang, Yu, Guan-Qiao, Zhu, Jia-Bi, He, Zhishui, Xie, Rong, Terakado, Junko, Yoneyama, Tadakatsu, Fujihara, Shinsuke, Ooki, Y., Banba, M., Yano, K., Maruya, J., Sato, S., Tabata, S., Saeki, K., Hayashi, M., Kawaguchi, M., Izui, K., Hata, S., Deguchi, Y., Checchetka, S.A., Bamba, M., Maeda, D., Ashida, K., Iguchi, K., Nomura, Mika, Thu, Mai Ha, Yokoyama, Tadashi, Hakoyama, Tsuneo, Arima, Yasuhiro, Shimoda, Y., Higashi, Shiro, Yukihiro, Maru, Hiroki, Miwa, Toshihiro, Aono, Hiroshi, Oyaizu, Wei, Hui, Layzell, David B., Du, Bing Hai, Wang, Lei, Qi, Su Wei, Jiang, Ju Quan, Yang, Su Sheng, Cheng, J., Sibley, C. D., Landry, T., Chain, P. S. G., Lehman, S., Golding, G. B., Yuan, Ze-Chun, Morton, Richard A., Zaheer, Rahat, Rybak, Adrian, Finan, Turlough M., Guillén-Navarro, Karina, Araíza, Gisela, Dunn, Michael F., Nakatsukasa, Hiroki, Wen, Jin, Nan, Bei-Yan, O’Gara, Fergal, Yue, Wen, Wen, Bi-Qing, Wang, Yi-Ping, Yao, Shi-Yi, Luo, Li, Har, Katherine J., Becker, Anke, Cheng, Hai-Ping, Sasakura, Fuyuko, Takenouchi, Katsumi, Wang, Yi-Ping, editor, Lin, Min, editor, Tian, Zhe-Xian, editor, Elmerich, Claudine, editor, and Newton, William E., editor

Published
2005
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15. IFPA Meeting 2011 workshop report I: Placenta: Predicting future health; roles of lipids in the growth and development of feto-placental unit; placental nutrient sensing; placental research to solve clinical problems – A translational approach

Author

Acharya, G., Albrecht, C., Benton, S.J., Cotechini, T., Dechend, R., Dilworth, M.R., Duttaroy, A.K., Grotmol, T., Heazell, A.E., Jansson, T., Johnstone, E.D., Jones, H.N., Jones, R.L., Lager, S., Laine, K., Nagirnaja, L., Nystad, M., Powell, T., Redman, C., Sadovsky, Y., Sibley, C., Troisi, R., Wadsack, C., Westwood, M., and Lash, G.E.

Published
2012
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17. Temporal distribution of Plasmodium falciparum recrudescence following artemisinin-based combination therapy: an individual participant data meta-analysis

Author

Dahal, P, Simpson, JA, Abdulla, S, Achan, J, Adam, I, Agarwal, A, Allan, R, Anvikar, AR, Ashley, EA, Bassat, Q, Borrmann, S, Bousema, T, Bukirwa, H, Carrara, V, Corsi, M, D'Alessandro, U, Davis, TME, Deloron, P, Desai, M, Dimbu, PR, Djalle, D, Djimde, A, Dorsey, G, Drakeley, CJ, Duparc, S, Edstein, MD, Espie, E, Abul, F, Falade, C, Fanello, C, Faucher, J-F, Faye, B, Fortes, FDJ, Gadalla, NB, Gaye, O, Gil, JP, Gilayeneh, J, Greenwood, B, Grivoyannis, A, Hien, TT, Hwang, J, Janssens, B, Juma, E, Kamugisha, E, Karema, C, Karunajeewa, HA, Kiechel, JR, Kironde, F, Kofoed, P-E, Kremsner, PG, Lee, SJ, Marsh, K, Martensson, A, Mayxay, M, Menan, H, Mens, P, Mutabingwa, TK, Ndiaye, J-L, Ngasala, BE, Noedl, H, Nosten, F, Offianan, AT, Ogutu, BR, Olliaro, PL, Ouedraogo, JB, Piola, P, Plowe, C, Plucinski, MM, Pratt, OJ, Premji, Z, Ramharter, M, Rogier, C, Vitare, P, Rombo, L, Rosenthal, PJ, Sibley, C, Sirima, S, Smithuis, F, Staedke, SG, Sutanto, I, Talisuna, AO, Tarning, J, Taylor, WRJ, Temu, E, Thriemer, K, Thuy-Nhien, N, Udhayakumar, V, Ursing, JD, van Herp, M, van Lenthe, M, van Vugt, M, William, Y, Winnips, C, Zaloumis, S, Zongo, I, White, NJ, Guerin, PJ, Stepniewska, K, Price, RN, Arinaitwe, E, Dahal, P, Simpson, JA, Abdulla, S, Achan, J, Adam, I, Agarwal, A, Allan, R, Anvikar, AR, Ashley, EA, Bassat, Q, Borrmann, S, Bousema, T, Bukirwa, H, Carrara, V, Corsi, M, D'Alessandro, U, Davis, TME, Deloron, P, Desai, M, Dimbu, PR, Djalle, D, Djimde, A, Dorsey, G, Drakeley, CJ, Duparc, S, Edstein, MD, Espie, E, Abul, F, Falade, C, Fanello, C, Faucher, J-F, Faye, B, Fortes, FDJ, Gadalla, NB, Gaye, O, Gil, JP, Gilayeneh, J, Greenwood, B, Grivoyannis, A, Hien, TT, Hwang, J, Janssens, B, Juma, E, Kamugisha, E, Karema, C, Karunajeewa, HA, Kiechel, JR, Kironde, F, Kofoed, P-E, Kremsner, PG, Lee, SJ, Marsh, K, Martensson, A, Mayxay, M, Menan, H, Mens, P, Mutabingwa, TK, Ndiaye, J-L, Ngasala, BE, Noedl, H, Nosten, F, Offianan, AT, Ogutu, BR, Olliaro, PL, Ouedraogo, JB, Piola, P, Plowe, C, Plucinski, MM, Pratt, OJ, Premji, Z, Ramharter, M, Rogier, C, Vitare, P, Rombo, L, Rosenthal, PJ, Sibley, C, Sirima, S, Smithuis, F, Staedke, SG, Sutanto, I, Talisuna, AO, Tarning, J, Taylor, WRJ, Temu, E, Thriemer, K, Thuy-Nhien, N, Udhayakumar, V, Ursing, JD, van Herp, M, van Lenthe, M, van Vugt, M, William, Y, Winnips, C, Zaloumis, S, Zongo, I, White, NJ, Guerin, PJ, Stepniewska, K, Price, RN, and Arinaitwe, E

Abstract

BACKGROUND: The duration of trial follow-up affects the ability to detect recrudescent infections following anti-malarial treatment. The aim of this study was to explore the proportions of recrudescent parasitaemia as ascribed by genotyping captured at various follow-up time-points in treatment efficacy trials for uncomplicated Plasmodium falciparum malaria. METHODS: Individual patient data from 83 anti-malarial efficacy studies collated in the WorldWide Antimalarial Resistance Network (WWARN) repository with at least 28 days follow-up were available. The temporal and cumulative distributions of recrudescence were characterized using a Cox regression model with shared frailty on study-sites. Fractional polynomials were used to capture non-linear instantaneous hazard. The area under the density curve (AUC) of the constructed distribution was used to estimate the optimal follow-up period for capturing a P. falciparum malaria recrudescence. Simulation studies were conducted based on the constructed distributions to quantify the absolute overestimation in efficacy due to sub-optimal follow-up. RESULTS: Overall, 3703 recurrent infections were detected in 60 studies conducted in Africa (15,512 children aged < 5 years) and 23 studies conducted in Asia and South America (5272 patients of all ages). Using molecular genotyping, 519 (14.0%) recurrences were ascribed as recrudescent infections. A 28 day artemether-lumefantrine (AL) efficacy trial would not have detected 58% [95% confidence interval (CI) 47-74%] of recrudescences in African children and 32% [95% CI 15-45%] in patients of all ages in Asia/South America. The corresponding estimate following a 42 day dihydroartemisinin-piperaquine (DP) efficacy trial in Africa was 47% [95% CI 19-90%] in children under 5 years old treated with > 48 mg/kg total piperaquine (PIP) dose and 9% [95% CI 0-22%] in those treated with ≤ 48 mg/kg PIP dose. In absolute terms, the simulation study found that trials limited to 28 days follow-up

Published
2022

18. Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data

Author

Mansoor, R, Commons, RJ, Douglas, NM, Abuaku, B, Achan, J, Adam, I, Adjei, GO, Adjuik, M, Alemayehu, BH, Allan, R, Allen, EN, Anvikar, AR, Arinaitwe, E, Ashley, EA, Ashurst, H, Asih, PBS, Bakyaita, N, Barennes, H, Barnes, K, Basco, L, Bassat, Q, Baudin, E, Bell, DJ, Bethell, D, Bjorkman, A, Boulton, C, Bousema, T, Brasseur, P, Bukirwa, H, Burrow, R, Carrara, V, Cot, M, D'Alessandro, U, Das, D, Das, S, Davis, TME, Desai, M, Djimde, AA, Dondorp, AM, Dorsey, G, Drakeley, CJ, Duparc, S, Espie, E, Etard, J-F, Falade, C, Faucher, JF, Filler, S, Fogg, C, Fukuda, M, Gaye, O, Genton, B, Rahim, AG, Gilayeneh, J, Gonzalez, R, Grais, RF, Grandesso, F, Greenwood, B, Grivoyannis, A, Hatz, C, Hodel, EM, Humphreys, GS, Hwang, J, Ishengoma, D, Juma, E, Kachur, SP, Kager, PA, Kamugisha, E, Kamya, MR, Karema, C, Kayentao, K, Kazienga, A, Kiechel, J-R, Kofoed, P-E, Koram, K, Kremsner, PG, Lalloo, DG, Laman, M, Lee, SJ, Lell, B, Maiga, AW, Martensson, A, Mayxay, M, Mbacham, W, McGready, R, Menan, H, Menard, D, Mockenhaupt, F, Moore, BR, Muller, O, Nahum, A, Ndiaye, J-L, Newton, PN, Ngasala, BE, Nikiema, F, Nji, AM, Noedl, H, Nosten, F, Ogutu, BR, Ojurongbe, O, Osorio, L, Ouedraogo, J-B, Owusu-Agyei, S, Pareek, A, Penali, LK, Piola, P, Plucinski, M, Premji, Z, Ramharter, M, Richmond, CL, Rombo, L, Rosenthal, PJ, Salman, S, Same-Ekobo, A, Sibley, C, Sirima, SB, Smithuis, FM, Some, FA, Staedke, SG, Starzengruber, P, Strub-Wourgaft, N, Sutanto, I, Swarthout, TD, Syafruddin, D, Talisuna, AO, Taylor, WR, Temu, EA, Thwing, J, Tinto, H, Tjitra, E, Toure, OA, Tran, TH, Ursing, J, Valea, I, Valentini, G, van Vugt, M, von Seidlein, L, Ward, SA, Were, V, White, NJ, Woodrow, CJ, Yavo, W, Yeka, A, Zongo, I, Simpson, JA, Guerin, PJ, Stepniewska, K, Price, RN, Roper, C, Mansoor, R, Commons, RJ, Douglas, NM, Abuaku, B, Achan, J, Adam, I, Adjei, GO, Adjuik, M, Alemayehu, BH, Allan, R, Allen, EN, Anvikar, AR, Arinaitwe, E, Ashley, EA, Ashurst, H, Asih, PBS, Bakyaita, N, Barennes, H, Barnes, K, Basco, L, Bassat, Q, Baudin, E, Bell, DJ, Bethell, D, Bjorkman, A, Boulton, C, Bousema, T, Brasseur, P, Bukirwa, H, Burrow, R, Carrara, V, Cot, M, D'Alessandro, U, Das, D, Das, S, Davis, TME, Desai, M, Djimde, AA, Dondorp, AM, Dorsey, G, Drakeley, CJ, Duparc, S, Espie, E, Etard, J-F, Falade, C, Faucher, JF, Filler, S, Fogg, C, Fukuda, M, Gaye, O, Genton, B, Rahim, AG, Gilayeneh, J, Gonzalez, R, Grais, RF, Grandesso, F, Greenwood, B, Grivoyannis, A, Hatz, C, Hodel, EM, Humphreys, GS, Hwang, J, Ishengoma, D, Juma, E, Kachur, SP, Kager, PA, Kamugisha, E, Kamya, MR, Karema, C, Kayentao, K, Kazienga, A, Kiechel, J-R, Kofoed, P-E, Koram, K, Kremsner, PG, Lalloo, DG, Laman, M, Lee, SJ, Lell, B, Maiga, AW, Martensson, A, Mayxay, M, Mbacham, W, McGready, R, Menan, H, Menard, D, Mockenhaupt, F, Moore, BR, Muller, O, Nahum, A, Ndiaye, J-L, Newton, PN, Ngasala, BE, Nikiema, F, Nji, AM, Noedl, H, Nosten, F, Ogutu, BR, Ojurongbe, O, Osorio, L, Ouedraogo, J-B, Owusu-Agyei, S, Pareek, A, Penali, LK, Piola, P, Plucinski, M, Premji, Z, Ramharter, M, Richmond, CL, Rombo, L, Rosenthal, PJ, Salman, S, Same-Ekobo, A, Sibley, C, Sirima, SB, Smithuis, FM, Some, FA, Staedke, SG, Starzengruber, P, Strub-Wourgaft, N, Sutanto, I, Swarthout, TD, Syafruddin, D, Talisuna, AO, Taylor, WR, Temu, EA, Thwing, J, Tinto, H, Tjitra, E, Toure, OA, Tran, TH, Ursing, J, Valea, I, Valentini, G, van Vugt, M, von Seidlein, L, Ward, SA, Were, V, White, NJ, Woodrow, CJ, Yavo, W, Yeka, A, Zongo, I, Simpson, JA, Guerin, PJ, Stepniewska, K, Price, RN, and Roper, C

Abstract

BACKGROUND: Plasmodium falciparum malaria is associated with anaemia-related morbidity, attributable to host, parasite and drug factors. We quantified the haematological response following treatment of uncomplicated P. falciparum malaria to identify the factors associated with malarial anaemia. METHODS: Individual patient data from eligible antimalarial efficacy studies of uncomplicated P. falciparum malaria, available through the WorldWide Antimalarial Resistance Network data repository prior to August 2015, were pooled using standardised methodology. The haematological response over time was quantified using a multivariable linear mixed effects model with nonlinear terms for time, and the model was then used to estimate the mean haemoglobin at day of nadir and day 7. Multivariable logistic regression quantified risk factors for moderately severe anaemia (haemoglobin < 7 g/dL) at day 0, day 3 and day 7 as well as a fractional fall ≥ 25% at day 3 and day 7. RESULTS: A total of 70,226 patients, recruited into 200 studies between 1991 and 2013, were included in the analysis: 50,859 (72.4%) enrolled in Africa, 18,451 (26.3%) in Asia and 916 (1.3%) in South America. The median haemoglobin concentration at presentation was 9.9 g/dL (range 5.0-19.7 g/dL) in Africa, 11.6 g/dL (range 5.0-20.0 g/dL) in Asia and 12.3 g/dL (range 6.9-17.9 g/dL) in South America. Moderately severe anaemia (Hb < 7g/dl) was present in 8.4% (4284/50,859) of patients from Africa, 3.3% (606/18,451) from Asia and 0.1% (1/916) from South America. The nadir haemoglobin occurred on day 2 post treatment with a mean fall from baseline of 0.57 g/dL in Africa and 1.13 g/dL in Asia. Independent risk factors for moderately severe anaemia on day 7, in both Africa and Asia, included moderately severe anaemia at baseline (adjusted odds ratio (AOR) = 16.10 and AOR = 23.00, respectively), young age (age < 1 compared to ≥ 12 years AOR = 12.81 and AOR = 6.79, respectively), high parasitaemia (AOR = 1.78 and AOR = 1.

Published
2022

19. IFPA Meeting 2010 Workshops Report II: Placental pathology; Trophoblast invasion; Fetal sex; Parasites and the placenta; Decidua and embryonic or fetal loss; Trophoblast differentiation and syncytialisation

Author

Al-Khan, A., Aye, I.L., Barsoum, I., Borbely, A., Cebral, E., Cerchi, G., Clifton, V.L., Collins, S., Cotechini, T., Davey, A., Flores-Martin, J., Fournier, T., Franchi, A.M., Fretes, R.E., Graham, C.H., Godbole, G., Hansson, S.R., Headley, P.L., Ibarra, C., Jawerbaum, A., Kemmerling, U., Kudo, Y., Lala, P.K., Lassance, L., Lewis, R.M., Menkhorst, E., Morris, C., Nobuzane, T., Ramos, G., Rote, N., Saffery, R., Salafia, C., Sarr, D., Schneider, H., Sibley, C., Singh, A.T., Sivasubramaniyam, T.S., Soares, M.J., Vaughan, O., Zamudio, S., and Lash, G.E.

Published
2011
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23. Sustained improvement in renal function with palopegteriparatide in adults with chronic hypoparathyroidism: 2-year results from the phase 3 PaTHway trial

Author

Kamenicky, P., Schwarz, P., Rejnmark, L., Gosmanova, E., Khan, A., Makita, N., Takeuchi, Y., Imanishi, Y., Sprague, S., Shoback, D., Kohlmeier, L., Rubin, M., Palermo, A., Gagnon, C., Tsourdi, E., Zhao, C., Makara, M., Ominsky, M., Lai, B., Ukena, J., Sibley, C., and Shu, A.

Abstract

This post hoc analysis examines the impact of palopegteriparatide on renal function in adults with chronic hypoparathyroidism through week 104 of PaTHway, a phase 3 trial with a randomized, double-blind, placebo-controlled 26-week period and ongoing 156-week open-label extension. Changes in renal function were assessed using eGFR. At week 104, 76 of 82 participants remained in the trial. Of those, 82% had normal albumin-adjusted serum calcium levels (2.07–2.64mmol/L), 97% were independent from conventional therapy, and none required active vitamin D. Mean (SD) serum phosphate (1.1 (0.2) mmol/L) and albumin-adjusted calcium x phosphate product (2.5 (0.4) mmol2/L2) were normal. At week 104, mean (SD) eGFR was 77.8 (14.8) mL/min/1.73m2. With palopegteriparatide treatment mean eGFR increased 8.9 (11.0) mL/min/1.73m2(P<.0001) from baseline to week 52, which was sustained through week 104 (mean (SD) change from baseline 9.0 (10.3) mL/min/1.73 m2(P<0.0001)). By week 104, 61% and 44% of participants had an increase in eGFR of ≥ 5mL/min/1.73 m2and ≥ 10mL/min/1.73 m2, respectively. Palopegteriparatide normalized mean 24-hour urine calcium within 26 weeks, maintaining levels below 6.2mmol/day through week 104 (4.0 (2.3) mmol/day). No cases of nephrolithiasis were reported with palopegteriparatide. Most TEAEs were mild or moderate; no new safety signals reported. These findings show sustained renal safety of palopegteriparatide and suggest that PTH replacement with palopegteriparatide and independence from conventional therapy may not only preserve but improve renal function in adults with chronic hypoparathyroidism.

Published
2024
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28. Cooperative phenotype predicts economic conservatism, policy views, and political party support

Author

Claessens, S., Sibley, C., Chaudhuri, A., Atkinson, Q., and https://orcid.org/0000-0002-8499-7535

Abstract

Decades of research suggest that our political differences are best captured by two dimensions of political ideology: economic and social conservatism. The dual evolutionary framework of political ideology predicts that these dimensions should be related to variation in general preferences for cooperation and group conformity. Here, we show that, controlling for a host of demographic covariates, a general cooperative preference captured by a suite of incentivised economic games (the "cooperative phenotype") is indeed negatively correlated with two widely-used measures of economic conservatism - Social Dominance Orientation and Schwartz's altruistic vs. self-enhancement values. The cooperative phenotype also predicts political party support and economically progressive views on political issues like income redistribution, welfare, taxation, and environmentalism. By contrast, a second "norm-enforcing punishment" dimension of economic game behaviour, expected to be a proxy for social conservatism and group conformity, showed no reliable relationship with political ideology. These findings reveal how general social preferences that evolved to help us navigate the challenges of group living continue to shape our political differences even today. - Cooperative phenotype predicts economic conservatism, policy views, and political party support - Results - Discussion - Methods - Participants -- Power analysis -- Participants and sampling - Materials -- New Zealand Attitudes and Values Survey measures -- Battery of economic games - Procedure - Statistical analysis

Published
2020

49. Poster Summaries

Author

Gucciardo, Sébastien, primary, Wisniewski, Jean-Pierre, additional, Mak, Lora, additional, Durrant, Marcus, additional, Rathbun, Elizabeth, additional, Brewin, Nick, additional, Suzuki, Akihiro, additional, Akune, Mitsumi, additional, Imagama, Yoshihiro, additional, Osuki, Ken-ichi, additional, Aoki, Toshio, additional, Uchiumi, Toshiki, additional, Abe, Mikiko, additional, Chou, Minxia, additional, Zhou, Junchu, additional, Xie, Bo, additional, Miao, Lihong, additional, Zhou, Kui, additional, Xie, Fuli, additional, Cheng, Xian-Guo, additional, Tajima, Shigeyuki, additional, Kouchi, Hiroshi, additional, Wang, Yanzhang, additional, Yu, Guan-Qiao, additional, Zhu, Jia-Bi, additional, He, Zhishui, additional, Xie, Rong, additional, Terakado, Junko, additional, Yoneyama, Tadakatsu, additional, Fujihara, Shinsuke, additional, Ooki, Y., additional, Banba, M., additional, Yano, K., additional, Maruya, J., additional, Sato, S., additional, Tabata, S., additional, Saeki, K., additional, Hayashi, M., additional, Kawaguchi, M., additional, Izui, K., additional, Hata, S., additional, Deguchi, Y., additional, Checchetka, S.A., additional, Bamba, M., additional, Maeda, D., additional, Ashida, K., additional, Iguchi, K., additional, Nomura, Mika, additional, Thu, Mai Ha, additional, Yokoyama, Tadashi, additional, Hakoyama, Tsuneo, additional, Arima, Yasuhiro, additional, Shimoda, Y., additional, Higashi, Shiro, additional, Yukihiro, Maru, additional, Hiroki, Miwa, additional, Toshihiro, Aono, additional, Hiroshi, Oyaizu, additional, Wei, Hui, additional, Layzell, David B., additional, Du, Bing Hai, additional, Wang, Lei, additional, Qi, Su Wei, additional, Jiang, Ju Quan, additional, Yang, Su Sheng, additional, Cheng, J., additional, Sibley, C. D., additional, Landry, T., additional, Chain, P. S. G., additional, Lehman, S., additional, Golding, G. B., additional, Yuan, Ze-Chun, additional, Morton, Richard A., additional, Zaheer, Rahat, additional, Rybak, Adrian, additional, Finan, Turlough M., additional, Guillén-Navarro, Karina, additional, Araíza, Gisela, additional, Dunn, Michael F., additional, Nakatsukasa, Hiroki, additional, Wen, Jin, additional, Nan, Bei-Yan, additional, O’Gara, Fergal, additional, Yue, Wen, additional, Wen, Bi-Qing, additional, Wang, Yi-Ping, additional, Yao, Shi-Yi, additional, Luo, Li, additional, Har, Katherine J., additional, Becker, Anke, additional, Cheng, Hai-Ping, additional, Sasakura, Fuyuko, additional, and Takenouchi, Katsumi, additional

Published
2005
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