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2. Incidence and pattern of urgent revascularization in acute coronary syndromes treated with ticagrelor or prasugrel

Author

Aytekin, Alp, Scalamogna, Maria, Coughlan, J. J., Lahu, Shqipdona, Ndrepepa, Gjin, Menichelli, Maurizio, Mayer, Katharina, Wöhrle, Jochen, Bernlochner, Isabell, Witzenbichler, Bernhard, Hochholzer, Willibald, Sibbing, Dirk, Angiolillo, Dominick J., Hemetsberger, Rayyan, Tölg, Ralph, Valina, Christian, Müller, Arne, Kufner, Sebastian, Liebetrau, Christoph, Xhepa, Erion, Hapfelmeier, Alexander, Sager, Hendrik B., Joner, Michael, Richardt, Gert, Laugwitz, Karl-Ludwig, Neumann, Franz Josef, Schunkert, Heribert, Schüpke, Stefanie, Kastrati, Adnan, and Cassese, Salvatore

Published
2024
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3. De-escalation or abbreviation of dual antiplatelet therapy in acute coronary syndromes and percutaneous coronary intervention: a Consensus Statement from an international expert panel on coronary thrombosis

Author

Gorog, Diana A., Ferreiro, Jose Luis, Ahrens, Ingo, Ako, Junya, Geisler, Tobias, Halvorsen, Sigrun, Huber, Kurt, Jeong, Young-Hoon, Navarese, Eliano P., Rubboli, Andrea, Sibbing, Dirk, Siller-Matula, Jolanta M., Storey, Robert F., Tan, Jack W. C., ten Berg, Jurrien M., Valgimigli, Marco, Vandenbriele, Christophe, and Lip, Gregory Y. H.

Published
2023
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5. Temporary mechanical circulatory support in infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials with 6-month follow-up

Author

Burkhoff, Daniel, Cohen, Howard, Brunckhorst, Corinna, O'Neill, William W., Thiele, Holger Thiele, Sick, Peter, Boudriot, Enno, Diederich, Klaus-Werner, Hambrecht, Rainer, Niebauer, Josef, Schuler, Gerhard, Seyfarth, Melchior, Sibbing, Dirk, Bauer, Iris, Fröhlich, Georg, Bott-Flügel, Lorenz, Byrne, Robert, Dirschinger, Josef, Kastrati, Adnan, Schömig, Albert, Ouweneel, Dagmar M., Eriksen, Erlend, Sjauw, Krischan D., van Dongen, Ivo M., Hirsch, Alexander, Packer, Erik J.S, Vis, M. Marie, Wykrzykowska, Joanna J., Koch, Karel T., Baan, Jan, De Winter, Robbert J, Piek, Jan J., Lagrand, Wim K, de Mol, Bas A.J.M, Tijssen, Jan G.P., Henriques, José P.S., Møller, Jacob E., Engstrøm, Thomas, Jensen, Lisette Okkels, Eiskjær, Hans, Mangner, Norman, Polzin, Amin, Schulze, P. Christian, Skurk, Carsten, Nordbeck, Peter, Clemmensen, Peter, Panoulas, Vasileios, Zimmer, Sebastian, Schäfer, Andreas, Werner, Nikos, Frydland, Martin, Holmvang, Lene, Kjærgaard, Jesper, Sørensen, Rikke, Lønborg, Jacob, Greve, Matias, Christiansen, Evald H., Linke, Axel, Woitek, Felix J., Westenfeld, Ralf, Moebius-Winkler, Sven, Wachtell, Kristian, Ravn, Hanne Berg, Lassen, Jens Flensted, Boesgaard, Søren, Gerke, Oke, Hassager, Christian, Lackermair, Korbinian, Brunner, Stefan, Orban, Mathias, Peterss, Sven, Orban, Martin, Theiss, Hans D., Huber, Bruno C., Juchem, Gerd, Born, Frank, Boulesteix, Anne-Laure, Bauer, Axel, Pichlmaier, Maximilian, Hausleiter, Jörg, Massberg, Steffen, Hagl, Christian, Guenther, Sabina P.W., Ostadal, Petr, Rokyta, Richard, Karasek, Jiri, Kruger, Andreas, Vondrakova, Dagmar, Janotka, Marek, Naar, Jan, Smalcova, Jana, Hubatova, Marketa, Hromadk, Milan, Volovar, Stefan, Seyfrydova, Miroslava, Jarkovsky, Jiri, Svoboda, Michal, Linhart, Ales, Belohlavek, Jan, Banning, Amerjeet S., Sabaté, Manel, Gracey, Jay, López-Sobrino, Teresa, Bogaerts, Kris, Adriaenssens, Tom, Berry, Colin, Erglis, Andrejs, Haine, Steven, Myrmel, Truls, Patel, Sameer, Buera, Irene, Sionis, Alessandro, Vilalta, Victoria, Yusuff, Hakeem, Vrints, Christiaan, Adlam, David, Flather, Marcus, Gershlick, Anthony H., Thiele, Holger, Zeymer, Uwe, Akin, Ibrahim, Behnes, Michael, Rassaf, Tienush, Mahabadi, Amir-Abbas, Lehmann, Ralf, Eitel, Ingo, Graf, Tobias, Seidler, Tim, Schuster, Andreas, Duerschmied, Daniel, Hennersdorf, Marcus, Fichtlscherer, Stephan, Voigt, Ingo, John, Stefan, Ewen, Sebastian, Tigges, Eike, Nordbeck, Peter Steffen, Bruch, Leonhard, Jung, Christian, Franz, Jutta, Lauten, Philipp, Goslar, Tomaz, Feistritzer, Hans-Josef, Pöss, Janine, Kirchhof, Eva, Ouarrak, Taoufik, Schneider, Steffen, Desch, Steffen, Freund, Anne, Møller, Jacob E, Henriques, Jose P S, Bogerd, Margriet, Hochadel, Matthias, and Schulze, P Christian

Published
2024
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6. High on-aspirin treatment platelet reactivity and restenosis after percutaneous coronary intervention: results of the Intracoronary Stenting and Antithrombotic Regimen-ASpirin and Platelet Inhibition (ISAR-ASPI) Registry

Author

Mayer, Katharina, Ndrepepa, Gjin, Schroeter, Mira, Emmer, Christopher, Bernlochner, Isabell, Schüpke, Stefanie, Gewalt, Senta, Hilz, Raphaela, Coughlan, John Joseph, Aytekin, Alp, Heyken, Clarissa, Morath, Tanja, Schunkert, Heribert, Laugwitz, Karl-Ludwig, Sibbing, Dirk, and Kastrati, Adnan

Published
2023
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7. Ticagrelor or prasugrel in patients with acute coronary syndrome with off-hour versus on-hour presentation: a subgroup analysis of the ISAR-REACT 5 trial

Author

Behnes, Michael, Lahu, Shqipdona, Ndrepepa, Gjin, Menichelli, Maurizio, Mayer, Katharina, Wöhrle, Jochen, Bernlochner, Isabell, Gewalt, Senta, Witzenbichler, Bernhard, Hochholzer, Willibald, Sibbing, Dirk, Cassese, Salvatore, Angiolillo, Dominick J., Hemetsberger, Rayyan, Valina, Christian, Müller, Arne, Kufner, Sebastian, Hamm, Christian W., Xhepa, Erion, Hapfelmeier, Alexander, Sager, Hendrik B., Joner, Michael, Fusaro, Massimiliano, Richardt, Gert, Laugwitz, Karl-Ludwig, Neumann, Franz-Josef, Schunkert, Heribert, Schüpke, Stefanie, Kastrati, Adnan, and Akin, Ibrahim

Published
2023
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9. Body mass index and efficacy and safety of ticagrelor versus prasugrel in patients with acute coronary syndromes

Author

Lahu, Shqipdona, Behnes, Michael, Ndrepepa, Gjin, Neumann, Franz-Josef, Sibbing, Dirk, Bernlochner, Isabell, Menichelli, Maurizio, Mayer, Katharina, Richardt, Gert, Gewalt, Senta, Angiolillo, Dominick J., Coughlan, John Joseph, Aytekin, Alp, Witzenbichler, Bernhard, Hochholzer, Willibald, Cassese, Salvatore, Kufner, Sebastian, Xhepa, Erion, Sager, Hendrik B., Joner, Michael, Fusaro, Massimiliano, Laugwitz, Karl-Ludwig, Schunkert, Heribert, Schüpke, Stefanie, Kastrati, Adnan, and Akin, Ibrahim

Published
2022
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10. Índice de masa corporal y eficacia y seguridad del ticagrelor frente al prasugrel en pacientes con síndrome coronario agudo

Author

Lahu, Shqipdona, Behnes, Michael, Ndrepepa, Gjin, Neumann, Franz-Josef, Sibbing, Dirk, Bernlochner, Isabell, Menichelli, Maurizio, Mayer, Katharina, Richardt, Gert, Gewalt, Senta, Angiolillo, Dominick J., Coughlan, John Joseph, Aytekin, Alp, Witzenbichler, Bernhard, Hochholzer, Willibald, Cassese, Salvatore, Kufner, Sebastian, Xhepa, Erion, Sager, Hendrik B., Joner, Michael, Fusaro, Massimiliano, Laugwitz, Karl-Ludwig, Schunkert, Heribert, Schüpke, Stefanie, Kastrati, Adnan, and Akin, Ibrahim

Published
2022
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11. Defining Strategies of Modulation of Antiplatelet Therapy in Patients With Coronary Artery Disease: A Consensus Document from the Academic Research Consortium

Author

Capodanno, Davide, Mehran, Roxana, Krucoff, Mitchell W., Baber, Usman, Bhatt, Deepak L., Capranzano, Piera, Collet, Jean-Philippe, Cuisset, Thomas, De Luca, Giuseppe, De Luca, Leonardo, Farb, Andrew, Franchi, Francesco, Gibson, C. Michael, Hahn, Joo-Yong, Hong, Myeong-Ki, James, Stefan, Kastrati, Adnan, Kimura, Takeshi, Lemos, Pedro A., Lopes, Renato D., Magee, Adrian, Matsumura, Ryosuke, Mochizuki, Shuichi, O’Donoghue, Michelle L., Pereira, Naveen L., Rao, Sunil V., Rollini, Fabiana, Shirai, Yuko, Sibbing, Dirk, Smits, Peter C., Steg, P. Gabriel, Storey, Robert F., ten Berg, Jurrien, Valgimigli, Marco, Vranckx, Pascal, Watanabe, Hirotoshi, Windecker, Stephan, Serruys, Patrick W., Yeh, Robert W., Morice, Marie-Claude, and Angiolillo, Dominick J.

Published
2023
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13. Ticagrelor or Prasugrel in Patients With Acute Coronary Syndrome in Relation to Estimated Glomerular Filtration Rate

Author

Wöhrle, Jochen, Seeger, Julia, Lahu, Shqipdona, Mayer, Katharina, Bernlochner, Isabell, Gewalt, Senta, Menichelli, Maurizio, Witzenbichler, Bernhard, Hochholzer, Willibald, Sibbing, Dirk, Cassese, Salvatore, Angiolillo, Dominick J., Hemetsberger, Rayyan, Valina, Christian, Kufner, Sebastian, Xhepa, Erion, Hapfelmeier, Alexander, Sager, Hendrik B., Joner, Michael, Richardt, Gert, Laugwitz, Karl-Ludwig, Neumann, Franz Josef, Schunkert, Heribert, Schüpke, Stefanie, Kastrati, Adnan, and Ndrepepa, Gjin

Published
2021
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14. Apixaban versus PhenpRocoumon: Oral AntiCoagulation plus antiplatelet tHerapy in patients with Acute Coronary Syndrome and Atrial Fibrillation (APPROACH-ACS-AF): Rationale and design of the prospective randomized parallel-group, open-label, blinded-endpoint, superiority, multicenter-trial of a triple therapy versus a dual therapy in patients with Atrial Fibrillation and Acute Coronary Syndrome undergoing coronary stenting

Author

Riesinger, Lisa, Strobl, Claudia, Leistner, David M., Gori, Tommaso, Akin, Ibrahim, Mehr, Michael, Kellnar, Antonia, Mahabadi, Amir A., Bogossian, Harilaos, Block, Michael, Edelmann, Frank, Sarafoff, Nikolaus, Sibbing, Dirk, Ince, Hüseyin, Rassaf, Tienush, Mansmann, Ulrich, Mehilli, Julinda, Kääb, Stefan, Hausleiter, Jörg, Massberg, Steffen, and Wakili, Reza

Published
2021
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15. Clopidogrel Versus Aspirin as Monotherapy Following Dual Antiplatelet Therapy in Patients With Acute Coronary Syndrome Receiving a Drug‐Eluting Stent: A Systematic Literature Review and Meta‐Analysis.

Author

Sibbing, Dirk, Nicolas, Johny, Spirito, Alessandro, Vogel, Birgit, Cao, Davide, Stipek, Wanda, Kasireddy, Ellen, Qian, Andi, Khan, Irfan, and Mehran, Roxana

Subjects
PLATELET aggregation inhibitors, ACUTE coronary syndrome, MAJOR adverse cardiovascular events, ANGINA pectoris, RANDOMIZED controlled trials
Abstract

Objective: This study aimed to evaluate the comparative effectiveness and safety of clopidogrel versus aspirin as monotherapy following adequate dual antiplatelet therapy (DAPT) in patients with acute coronary syndrome (ACS). Methods: MEDLINE, Embase, and CENTRAL were searched from database inception to September 1, 2023. Randomized controlled trials (RCTs) and observational studies evaluating the effectiveness or safety of clopidogrel versus aspirin as monotherapy following DAPT in patients with ACS who received a drug‐eluting stent were included. Random‐effects meta‐analyses were conducted to compare risks of major adverse cardiovascular events (MACE) and clinically relevant bleeding. Results: Of 6242 abstracts identified, three unique studies were included: one RCT and two retrospective cohort studies. Studies included a total of 7081 post‐percutaneous coronary intervention ACS patients, 4260 of whom received aspirin monotherapy and 2821 received clopidogrel monotherapy. Studies included variable proportions of patients with ST‐elevation myocardial infarction (STEMI), non‐STEMI, and unstable angina. From the meta‐analysis, clopidogrel was associated with a 28% reduction in the risk of MACE compared with aspirin (hazard ratio [HR]: 0.72; 95% confidence interval [CI]: 0.54, 0.98), with no significant difference in clinically relevant bleeding (HR: 0.92; 95% CI: 0.68, 1.24). Conclusion: Despite the paucity of published evidence on the effectiveness and safety of clopidogrel versus aspirin in patients with ACS post‐drug‐eluting stent implantation, this meta‐analysis suggests that clopidogrel versus aspirin may result in a lower risk of MACE, with a similar risk of major bleeding. The present results are hypothesis‐generating and further large RCTs comparing antiplatelet monotherapy options in ACS patients are warranted. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Ticagrelor or Prasugrel in Patients With Acute Coronary Syndrome and High Bleeding Risk

Author

Lahu, Shqipdona, Presch, Antonia, Ndrepepa, Gjin, Menichelli, Maurizio, Valina, Christian, Hemetsberger, Rayyan, Witzenbichler, Bernhard, Bernlochner, Isabell, Joner, Michael, Xhepa, Erion, Hapfelmeier, Alexander, Kufner, Sebastian, Rifatov, Nonglag, Sager, Hendrik B., Mayer, Katharina, Kessler, Thorsten, Laugwitz, Karl-Ludwig, Richardt, Gert, Schunkert, Heribert, Neumann, Franz-Josef, Sibbing, Dirk, Angiolillo, Dominick J., Kastrati, Adnan, and Cassese, Salvatore

Published
2022
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20. Antithrombotische Therapie nach strukturellen kardialen Interventionen: Empfehlung der Arbeitsgruppe Kardiovaskuläre Hämostase und Antithrombotische Therapie (AG19) der Deutschen Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e. V. (DGK) in Zusammenarbeit mit der Arbeitsgruppe Interventionelle Kardiologie (AG6) – AGIK und der Arbeitsgruppe Klinische Pharmakologie (AG22) der DGK

Author

Hochholzer, Willibald, Nührenberg, Thomas, Flierl, Ulrike, Olivier, Christoph B., Landmesser, Ulf, Möllmann, Helge, Dörr, Marcus, Mehilli, Julinda, Schäfer, Andreas, Dürschmied, Daniel, Sibbing, Dirk, El-Armouche, Ali, Zeymer, Uwe, Neumann, Franz-Josef, Ahrens, Ingo, and Geisler, Tobias

Published
2021
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21. Demystifying the Contemporary Role of 12-Month Dual Antiplatelet Therapy After Acute Coronary Syndrome

Author

Valgimigli, Marco, Landi, Antonio, Angiolillo, Dominick J., Baber, Usman, Bhatt, Deepak L., Bonaca, Marc P., Capodanno, Davide, Cohen, David J., Gibson, C. Michael, James, Stefan, Kimura, Takeshi, Lopes, Renato D., Mehta, Shamir R., Montalescot, Gilles, Sibbing, Dirk, Steg, P. Gabriel, Stone, Gregg W., Storey, Robert F., Vranckx, Pascal, Windecker, Stephan, Mehran, Roxana, Valgimigli, Marco, Landi, Antonio, Angiolillo, Dominick J., Baber, Usman, Bhatt, Deepak L., Bonaca, Marc P., Capodanno, Davide, Cohen, David J., Gibson, C. Michael, James, Stefan, Kimura, Takeshi, Lopes, Renato D., Mehta, Shamir R., Montalescot, Gilles, Sibbing, Dirk, Steg, P. Gabriel, Stone, Gregg W., Storey, Robert F., Vranckx, Pascal, Windecker, Stephan, and Mehran, Roxana

Abstract

For almost two decades, 12-month dual antiplatelet therapy (DAPT) in acute coronary syndrome (ACS) has been the only class I recommendation on DAPT in American and European guidelines, which has resulted in 12-month durations of DAPT therapy being the most frequently implemented in ACS patients undergoing percutaneous coronary intervention (PCI) across the globe. Twelve-month DAPT was initially grounded in the results of the CURE (Clopidogrel in Unstable Angina to Prevent Recurrent Events) trial, which, by design, studied DAPT versus no DAPT rather than the optimal DAPT duration. The average DAPT duration in this study was 9 months, not 12 months. Subsequent ACS studies, which were not designed to assess DAPT duration, rather its composition (aspirin with prasugrel or ticagrelor compared with clopidogrel) were further interpreted as supportive evidence for 12-month DAPT duration. In these studies, the median DAPT duration was 9 or 15 months for ticagrelor and prasugrel, respectively. Several subsequent studies questioned the 12-month regimen and suggested that DAPT duration should either be fewer than 12 months in patients at high bleeding risk or more than 12 months in patients at high ischemic risk who can safely tolerate the treatment. Bleeding, rather than ischemic risk assessment, has emerged as a treatment modifier for maximizing the net clinical benefit of DAPT, due to excessive bleeding and no clear benefit of prolonged treatment regimens in high bleeding risk patients. Multiple DAPT de-escalation treatment strategies, including switching from prasugrel or ticagrelor to clopidogrel, reducing the dose of prasugrel or ticagrelor, and shortening DAPT duration while maintaining monotherapy with ticagrelor, have been consistently shown to reduce bleeding without increasing fatal or nonfatal cardiovascular or cerebral ischemic risks compared with 12-month DAPT. However, 12-month DAPT remains the only class-I DAPT recommendation for patients with ACS despite the la

Published
2024
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22. Updated Expert Consensus Statement on Platelet Function and Genetic Testing for Guiding P2Y12 Receptor Inhibitor Treatment in Percutaneous Coronary Intervention

Author

Sibbing, Dirk, Aradi, Daniel, Alexopoulos, Dimitrios, ten Berg, Jurrien, Bhatt, Deepak L., Bonello, Laurent, Collet, Jean-Philippe, Cuisset, Thomas, Franchi, Francesco, Gross, Lisa, Gurbel, Paul, Jeong, Young-Hoon, Mehran, Roxana, Moliterno, David J., Neumann, Franz-Josef, Pereira, Naveen L., Price, Matthew J., Sabatine, Marc S., So, Derek Y.F., Stone, Gregg W., Storey, Robert F., Tantry, Udaya, Trenk, Dietmar, Valgimigli, Marco, Waksman, Ron, and Angiolillo, Dominick J.

Published
2019
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23. Switching Platelet P2Y12Receptor Inhibiting Therapies

Author

Ortega-Paz, Luis, Rollini, Fabiana, Franchi, Francesco, Sibbing, Dirk, and Angiolillo, Dominick J.

Abstract

Antiplatelet therapy involving aspirin and a P2Y12receptor inhibitor is fundamental in managing patients with atherothrombotic disease. Switching between P2Y12inhibitors is frequently observed in clinical settings for various reasons, such as safety, efficacy, patient adherence, or cost concerns. Although it occurs often, the optimal method for switching remains a concern owing to potential drug interactions, which can result in either inadequate platelet inhibition and subsequent thrombotic events or low platelet reactivity and increased bleeding risks due to therapy overlap. This review offers practical guidance on switching P2Y12inhibitors, drawing from pharmacodynamic and clinical data.

Published
2024
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24. Temporary mechanical circulatory support in infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials with 6-month follow-up

Author

Thiele, Holger, Møller, Jacob E, Henriques, Jose P S, Bogerd, Margriet, Seyfarth, Melchior, Burkhoff, Daniel, Ostadal, Petr, Rokyta, Richard, Belohlavek, Jan, Massberg, Steffen, Flather, Marcus, Hochadel, Matthias, Schneider, Steffen, Desch, Steffen, Freund, Anne, Eiskjær, Hans, Mangner, Norman, Pöss, Janine, Polzin, Amin, Schulze, P Christian, Skurk, Carsten, Zeymer, Uwe, Hassager, Christian, Burkhoff, Daniel, Cohen, Howard, Brunckhorst, Corinna, O'Neill, William W., Thiele, Holger Thiele, Sick, Peter, Boudriot, Enno, Diederich, Klaus-Werner, Hambrecht, Rainer, Niebauer, Josef, Schuler, Gerhard, Seyfarth, Melchior, Sibbing, Dirk, Bauer, Iris, Fröhlich, Georg, Bott-Flügel, Lorenz, Byrne, Robert, Dirschinger, Josef, Kastrati, Adnan, Schömig, Albert, Ouweneel, Dagmar M., Eriksen, Erlend, Sjauw, Krischan D., van Dongen, Ivo M., Hirsch, Alexander, Packer, Erik J.S, Vis, M. Marie, Wykrzykowska, Joanna J., Koch, Karel T., Baan, Jan, De Winter, Robbert J, Piek, Jan J., Lagrand, Wim K, de Mol, Bas A.J.M, Tijssen, Jan G.P., Henriques, José P.S., Møller, Jacob E., Engstrøm, Thomas, Jensen, Lisette Okkels, Eiskjær, Hans, Mangner, Norman, Polzin, Amin, Schulze, P. Christian, Skurk, Carsten, Nordbeck, Peter, Clemmensen, Peter, Panoulas, Vasileios, Zimmer, Sebastian, Schäfer, Andreas, Werner, Nikos, Frydland, Martin, Holmvang, Lene, Kjærgaard, Jesper, Sørensen, Rikke, Lønborg, Jacob, Greve, Matias, Christiansen, Evald H., Linke, Axel, Woitek, Felix J., Westenfeld, Ralf, Moebius-Winkler, Sven, Wachtell, Kristian, Ravn, Hanne Berg, Lassen, Jens Flensted, Boesgaard, Søren, Gerke, Oke, Hassager, Christian, Lackermair, Korbinian, Brunner, Stefan, Orban, Mathias, Peterss, Sven, Orban, Martin, Theiss, Hans D., Huber, Bruno C., Juchem, Gerd, Born, Frank, Boulesteix, Anne-Laure, Bauer, Axel, Pichlmaier, Maximilian, Hausleiter, Jörg, Massberg, Steffen, Hagl, Christian, Guenther, Sabina P.W., Ostadal, Petr, Rokyta, Richard, Karasek, Jiri, Kruger, Andreas, Vondrakova, Dagmar, Janotka, Marek, Naar, Jan, Smalcova, Jana, Hubatova, Marketa, Hromadk, Milan, Volovar, Stefan, Seyfrydova, Miroslava, Jarkovsky, Jiri, Svoboda, Michal, Linhart, Ales, Belohlavek, Jan, Banning, Amerjeet S., Sabaté, Manel, Orban, Martin, Gracey, Jay, López-Sobrino, Teresa, Massberg, Steffen, Kastrati, Adnan, Bogaerts, Kris, Adriaenssens, Tom, Berry, Colin, Erglis, Andrejs, Haine, Steven, Myrmel, Truls, Patel, Sameer, Buera, Irene, Sionis, Alessandro, Vilalta, Victoria, Yusuff, Hakeem, Vrints, Christiaan, Adlam, David, Flather, Marcus, Gershlick, Anthony H., Thiele, Holger, Zeymer, Uwe, Akin, Ibrahim, Behnes, Michael, Rassaf, Tienush, Mahabadi, Amir-Abbas, Lehmann, Ralf, Eitel, Ingo, Graf, Tobias, Seidler, Tim, Schuster, Andreas, Skurk, Carsten, Duerschmied, Daniel, Clemmensen, Peter, Hennersdorf, Marcus, Fichtlscherer, Stephan, Voigt, Ingo, Seyfarth, Melchior, John, Stefan, Ewen, Sebastian, Linke, Axel, Tigges, Eike, Nordbeck, Peter Steffen, Bruch, Leonhard, Jung, Christian, Franz, Jutta, Lauten, Philipp, Goslar, Tomaz, Feistritzer, Hans-Josef, Pöss, Janine, Kirchhof, Eva, Ouarrak, Taoufik, Schneider, Steffen, Desch, Steffen, and Freund, Anne

Abstract

Percutaneous active mechanical circulatory support (MCS) devices are being increasingly used in the treatment of acute myocardial infarction-related cardiogenic shock (AMICS) despite conflicting evidence regarding their effect on mortality. We aimed to ascertain the effect of early routine active percutaneous MCS versus control treatment on 6-month all-cause mortality in patients with AMICS.

Published
2024
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25. Messungen der ADP-induzierten Thrombozytenaggregation mittels optischer Aggregometrie nach Born und mittels Multiplate Analyter aus Vollblut nach Gabe einer 600 mg Loadingdosis Clopidogrel.

Author

Sibbing, Dirk (Prof. Dr.), Sibbing, Dirk (Prof. Dr.);Ewert, Peter (Prof. Dr.), Jawansky, Stefan, Sibbing, Dirk (Prof. Dr.), Sibbing, Dirk (Prof. Dr.);Ewert, Peter (Prof. Dr.), and Jawansky, Stefan

Abstract

Es hat sich gezeigt, dass das Maß der Plättchenaggregation, welches mit der optischen Aggregometrie (LTA) in Plättchenreichem Plasma (PRP) gemessen wird, mit der Prognose nach einer perkutanen Koronarintervention (PCI) zusammen hängt. Messungen der Plättchenfunktion mit LTA sind jedoch zeitaufwendig. Eine neue Methode, die mehrfach Elektroden Aggregometrie (MEA), wurde zur schnellen Messung der Plättchenaggregation in Vollblut entwickelt. Ziel der Studie war ein Vergleich der Plättchenfunktion mit MEA und LTA vor und nach einer Gabe von 600 mg Clopidogrel., The level of platelet aggregation, measured with light transmission aggregometry (LTA) in platelet rich plasma (PRP), has been shown to predict outcomes after percutaneous coronary intervention (PCI). However, measuring parameters of platelet function with LTA is time consuming. A new method, multiple electrode aggregometry (MEA), to rapidly measure platelet aggregation in whole blood has been developed. The aim of this study was to assess parameters of platelet function with MEA and LTA before and after administration of 600 mg clopidogrel.

Published
2023

27. Guided de-escalation of DAPT in acute coronary syndrome patients undergoing percutaneous coronary intervention with BVS implantation: a post-hoc analysis from the randomized TROPICAL-ACS trial

Author

Koltowski, Lukasz, Tomaniak, Mariusz, Gross, Lisa, Rymuza, Bartosz, Kowara, Michal, Parma, Radoslaw, Komosa, Anna, Klopotowski, Mariusz, Jacobshagen, Claudius, Gori, Tommaso, Aradi, Daniel, Huber, Kurt, Hadamitzky, Martin, Massberg, Steffen, Lesiak, Maciej, Filipiak, Krzysztof J., Witkowski, Adam, Opolski, Grzegorz, Huczek, Zenon, and Sibbing, Dirk

Published
2019
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29. Guided de-escalation of antiplatelet treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention (TROPICAL-ACS): a randomised, open-label, multicentre trial

Author

Parma, Radoslaw, Parma, Zofia, Lesiak, Maciej, Komosa, Anna, Huczek, Zenon, Koltowski, Lukasz, Kowara, Michal, Rymuza, Bartosz, Klopotowski, Mariusz, Malek, Lukasz, Aradi, Daniel, Veress, Gábor, Dézsi, András Döme, Merkely, Béla, Lux, Árpád, Kiss, Róbert Gábor, Papp, Judit, Kovács, Andrea, Dézsi, Csaba András, Amer, Sayour, Ruzsa, Zoltán, Róna, Szilárd, Komócsi, András, Ili, Renáta, Ungi, Imre, Nagy, Ferenc, Zweiker, Robert, Tóth-Gayor, Gábor, Huber, Kurt, Haller, Paul, von Scheidt, Wolfgang, Blüthgen, Andreas, Neumann, Franz-Josef, Trenk, Dietmar, Leggewie, Stefan, Kreider-Stempfle, Hans Ulrich, Remp, Thomas, Kara, Kaffer, Mügge, Andreas, Wutzler, Alexander, Fichtlscherer, Stephan, Zeiher, Andreas M., Seeger, Florian, Hinterseer, Martin, König, Andreas, Lederle, Susanne, Jacobshagen, Claudius, Czepluch, Frauke, Maier, Lars, Schillinger, Wolfgang, Sossalla, Samuel, Hummel, Astrid, Felix, Stephan, Karakas, Mahir, Sydow, Karsten, Rudolph, Tanja, Halbach, Marcel, Gori, Tommaso, Münzel, Thomas, May, Andreas, Gerstenberg, Carsten-Manuel, Pilecky, David, Rieber, Johannes, Deichstetter, Markus, Sibbing, Dirk, Mehilli, Julinda, Gross, Lisa, Kääb, Stefan, Löw, Anja, Orban, Martin, Orban, Matthias, Sattler, Stefan, Deuschl, Sabine, Teupser, Daniel, Holdt, Lesca, Mudra, Harald, Räder, Thomas, Schütz, Torsten, Vahldiek, Felix, Divchev, Dimitar, Ince, Hüseyin, Nienaber, Christoph A, Radunski, Henning, Boekstegers, Peter, Horstkotte, Jan, Mueller, Ralf, Geisler, Tobias, Müller, Karin, Schwinger, Robert, Rasp, Oliver, Aradi, Dániel, Hadamitzky, Martin, Dézsi, Csaba A, Felix, Stephan B, Schwinger, Robert H G, and Massberg, Steffen

Published
2017
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32. Ticagrelor or Prasugrel in Patients With ST-Segment–Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Author

Aytekin, Alp, Ndrepepa, Gjin, Neumann, Franz-Josef, Menichelli, Maurizio, Mayer, Katharina, Wöhrle, Jochen, Bernlochner, Isabell, Lahu, Shqipdona, Richardt, Gert, Witzenbichler, Bernhard, Sibbing, Dirk, Cassese, Salvatore, Angiolillo, Dominick J., Valina, Christian, Kufner, Sebastian, Liebetrau, Christoph, Hamm, Christian W., Xhepa, Erion, Hapfelmeier, Alexander, Sager, Hendrik B., Wustrow, Isabel, Joner, Michael, Trenk, Dietmar, Fusaro, Massimiliano, Laugwitz, Karl-Ludwig, Schunkert, Heribert, Schüpke, Stefanie, and Kastrati, Adnan

Published
2020
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34. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

Author

Collet, Jean-Philippe, Thiele, Holger, Barbato, Emanuele, Barthélémy, Olivier, Bauersachs, Johann, Bhatt, Deepak L., Dendale, Paul, Dorobantu, Maria, Edvardsen, Thor, Folliguet, Thierry, Gale, Chris P., Gilard, Martine, Jobs, Alexander, Jüni, Peter, Lambrinou, Ekaterini, Lewis, Basil S., Mehilli, Julinda, Meliga, Emanuele, Merkely, Béla, Mueller, Christian, Roffi, Marco, Rutten, Frans H., Sibbing, Dirk, and Siontis, George C.M.

Published
2021
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35. Guía ESC 2020 sobre el diagnóstico y tratamiento del síndrome coronario agudo sin elevación del segmento ST: Grupo de Trabajo de la Sociedad Europea de Cardiología (ESC) para el diagnóstico y tratamiento del síndrome coronario agudo (SCA) en pacientes sin elevación persistente del segmento ST

Author

Collet, Jean-Philippe, Thiele, Holger, Barbato, Emanuele, Barthélémy, Olivier, Bauersachs, Johann, Bhatt, Deepak L., Dendale, Paul, Dorobantu, Maria, Edvardsen, Thor, Folliguet, Thierry, Gale, Chris P., Gilard, Martine, Jobs, Alexander, Jüni, Peter, Lambrinou, Ekaterini, Lewis, Basil S., Mehilli, Julinda, Meliga, Emanuele, Merkely, Béla, Mueller, Christian, Roffi, Marco, Rutten, Frans H., Sibbing, Dirk, and Siontis, George C.M.

Published
2021
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39. Acute, periprocedural and longterm antithrombotic therapy in older adults: 2022 Update by the ESC Working Group on Thrombosis

Author

Andreotti, Felicita, Geisler, Tobia, Collet, Jean-Philippe, Gigante, Bruna, Gorog, Diana A, Halvorsen, Sigrun, Lip, Gregory Y H, Morais, Joao, Navarese, Eliano Pio, Patrono, Carlo, Rocca, Bianca, Rubboli, Andrea, Sibbing, Dirk, Storey, Robert F, Verheugt, Freek W A, Vilahur, Gemma, Andreotti, Felicita (ORCID:0000-0002-1456-6430), Rocca, Bianca (ORCID:0000-0001-8304-6423), Andreotti, Felicita, Geisler, Tobia, Collet, Jean-Philippe, Gigante, Bruna, Gorog, Diana A, Halvorsen, Sigrun, Lip, Gregory Y H, Morais, Joao, Navarese, Eliano Pio, Patrono, Carlo, Rocca, Bianca, Rubboli, Andrea, Sibbing, Dirk, Storey, Robert F, Verheugt, Freek W A, Vilahur, Gemma, Andreotti, Felicita (ORCID:0000-0002-1456-6430), and Rocca, Bianca (ORCID:0000-0001-8304-6423)

Abstract

The first international guidance on antithrombotic therapy in the elderly came from the European Society of Cardiology Working Group on Thrombosis in 2015. This same group has updated its previous report on antiplatelet and anticoagulant drugs for older patients with acute or chronic coronary syndromes, atrial fibrillation, or undergoing surgery or procedures typical of the elderly (transcatheter aortic valve implantation and left atrial appendage closure). The aim is to provide a succinct but comprehensive tool for readers to understand the bases of antithrombotic therapy in older patients, despite the complexities of comorbidities, comedications and uncertain ischaemic- vs. bleeding-risk balance. Fourteen updated consensus statements integrate recent trial data and other evidence, with a focus on high bleeding risk. Guideline recommendations, when present, are highlighted, as well as gaps in evidence. Key consensus points include efforts to improve medical adherence through deprescribing and polypill use; adoption of universal risk definitions for bleeding, myocardial infarction, stroke and cause-specific death; multiple bleeding-avoidance strategies, ranging from gastroprotection with aspirin use to selection of antithrombotic-drug composition, dosing and duration tailored to multiple variables (setting, history, overall risk, age, weight, renal function, comedications, procedures) that need special consideration when managing older adults.

Published
2023

41. Dual antiplatelet therapy de-escalation in acute coronary syndrome: an individual patient meta-analysis

Author

Kang, Jeehoon, primary, Rizas, Konstantinos D, additional, Park, Kyung Woo, additional, Chung, Jaewook, additional, van den Broek, Wout, additional, Claassens, Daniel M F, additional, Choo, Eun ho, additional, Aradi, Dániel, additional, Massberg, Steffen, additional, Hwang, Doyeon, additional, Han, Jung-Kyu, additional, Yang, Han-Mo, additional, Kang, Hyun-Jae, additional, Chang, Kiyuk, additional, ten Berg, Jur M, additional, Sibbing, Dirk, additional, Koo, Bon-Kwon, additional, and Kim, Hyo-Soo, additional

Published
2023
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44. Immature Platelet Fraction Predicts Adverse Events in Patients With Acute Coronary Syndrome: the ISAR-REACT 5 Reticulated Platelet Substudy

Author

Bongiovanni, Dario, primary, Schreiner, Nina, additional, Gosetti, Rosanna, additional, Mayer, Katharina, additional, Angiolillo, Dominick J., additional, Sibbing, Dirk, additional, Holdenrieder, Stefan, additional, Anetsberger, Aida, additional, von Scheidt, Moritz, additional, Schunkert, Heribert, additional, Laugwitz, Karl-Ludwig, additional, Schüpke, Stefanie, additional, Kastrati, Adnan, additional, Fegers-Wustrow, Isabel, additional, and Bernlochner, Isabell, additional

Published
2023
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46. The impact of therapeutic hypothermia on on-treatment platelet reactivity and clinical outcome in cardiogenic shock patients undergoing primary PCI for acute myocardial infarction: Results from the ISAR-SHOCK registry

Author

Orban, Martin, Mayer, Katharina, Morath, Tanja, Bernlochner, Isabell, Hadamitzky, Martin, Braun, Siegmund, Schulz, Stefanie, Hoppmann, Petra, Hausleiter, Jörg, Tiroch, Klaus, Mehilli, Julinda, Schunkert, Heribert, Massberg, Steffen, Laugwitz, Karl-Ludwig, Sibbing, Dirk, and Kastrati, Adnan

Published
2015
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48. De-escalation or abbreviation of dual antiplatelet therapy in acute coronary syndromes and percutaneous coronary intervention: a Consensus Statement from an international expert panel on coronary thrombosis

Author

Gorog, Diana A, Ferreiro, Jose Luis, Ahrens, Ingo, Ako, Junya, Geisler, Tobias, Halvorsen, Sigrun, Huber, Kurt, Jeong, Young-Hoon, Navarese, Eliano P, Rubboli, Andrea, Sibbing, Dirk, Siller-Matula, Jolanta M, Storey, Robert F, Tan, Jack W C, Ten Berg, Jurrien M, Valgimigli, Marco, Vandenbriele, Christophe, and Lip, Gregory Y H

Subjects
610 Medicine & health
Abstract

Conventional dual antiplatelet therapy (DAPT) for patients with acute coronary syndromes undergoing percutaneous coronary intervention comprises aspirin with a potent P2Y purinoceptor 12 (P2Y12) inhibitor (prasugrel or ticagrelor) for 12 months. Although this approach reduces ischaemic risk, patients are exposed to a substantial risk of bleeding. Strategies to reduce bleeding include de-escalation of DAPT intensity (downgrading from potent P2Y12 inhibitor at conventional doses to either clopidogrel or reduced-dose prasugrel) or abbreviation of DAPT duration. Either strategy requires assessment of the ischaemic and bleeding risks of each individual. De-escalation of DAPT intensity can reduce bleeding without increasing ischaemic events and can be guided by platelet function testing or genotyping. Abbreviation of DAPT duration after 1-6 months, followed by monotherapy with aspirin or a P2Y12 inhibitor, reduces bleeding without an increase in ischaemic events in patients at high bleeding risk, particularly those without high ischaemic risk. However, these two strategies have not yet been compared in a head-to-head clinical trial. In this Consensus Statement, we summarize the evidence base for these treatment approaches, provide guidance on the assessment of ischaemic and bleeding risks, and provide consensus statements from an international panel of experts to help clinicians to optimize these DAPT approaches for individual patients to improve outcomes.

Published
2023
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49. Acute, periprocedural and longterm antithrombotic therapy in older adults

Author

Andreotti, Felicita, primary, Geisler, Tobias, additional, Collet, Jean-Philippe, additional, Gigante, Bruna, additional, Gorog, Diana A, additional, Halvorsen, Sigrun, additional, Lip, Gregory Y H, additional, Morais, Joao, additional, Navarese, Eliano Pio, additional, Patrono, Carlo, additional, Rocca, Bianca, additional, Rubboli, Andrea, additional, Sibbing, Dirk, additional, Storey, Robert F, additional, Verheugt, Freek W A, additional, and Vilahur, Gemma, additional

Published
2022
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50. Association between Platelet Count and Treatment Effect of Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes

Author

Koch, Tobias, additional, Lahu, Shqipdona, additional, Coughlan, J. J., additional, Cassese, Salvatore, additional, Voll, Felix, additional, Ndrepepa, Gjin, additional, Menichelli, Maurizio, additional, Valina, Christian, additional, Hemetsberger, Rayyan, additional, Witzenbichler, Bernhard, additional, Bernlochner, Isabell, additional, Joner, Michael, additional, Xhepa, Erion, additional, Mayer, Katharina, additional, Kessler, Thorsten, additional, Laugwitz, Karl-Ludwig, additional, Richardt, Gert, additional, Schunkert, Heribert, additional, Angiolillo, Dominick J., additional, Sibbing, Dirk, additional, Kastrati, Adnan, additional, and Kufner, Sebastian, additional

Published
2022
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