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The parotid duct has been reported to be the most common site of sialoliths in horses. In this case report, we described the first confirmed case of the equine sialolithiasis in Slovakia. The work was aimed to describe the transcutaneous approach to removing the sialolith, which manifested as a hard painless mass in the area of the maxillary cheek teeth, in a 14-year-old Slovakian warmblood mare. Pathological-anatomical and histological examination after extirpation confirmed the presence of parotid duct ectasia resulting from calculus. The mineral composition of the sialolith was determined with atomic absorption spectroscopy using X-ray powder diffraction. The sialolith was successfully extirpated transcutaneously, without complications or recurrence. [ABSTRACT FROM AUTHOR]

Three Caspian miniature horses, exhibiting facial swellings, were examined in Alborz province. Physical examinations denoted sialolithiasis in two patients, and arose suspicion of the same condition in the third patient. The sialoliths were removed using a transcutaneous surgical approach with standing sedation using xylazine (1mg/kg, intravenously) and local anaesthesia with lidocaine (5-10 mL) in all three patients. In Case 1, multiple pieces of stone were excised from the left parotid duct using a transcutaneous approach. InCase 2, a single oval-shaped stone (44 g) was excised fromthe right parotid duct with the same technique as mentioned above. Case 3 presented a 1-g amorphous stone partially obstructing the right parotid duct, resulting in cyst formation on the right aspect of the face. Chemical analysis identified calcium carbonate as the primary component. Given the distribution of horses in Iran, accurate estimation of the frequency of sialolithiasis is quite challenging, and numerous cases are overlooked. [ABSTRACT FROM AUTHOR]

This article discusses the techniques, complications, and success rate of removing salivary stones in a cohort study. The study found that sialendoscopy should be the first-line treatment for these stones, and for larger or impacted stones, the transfacial-endoscopic approach should be considered. The article also highlights that some procedures can be done under local anesthesia, saving time and costs. The study found that antibiotics are not necessary for uncomplicated removal of the stones, and parotidectomy is rarely needed. The data shows that larger stones required a transfacial approach and took longer to remove. Complications occurred in 16% of patients, with chronic illnesses, prophylactic antibiotics, and transfacial procedures being associated with a higher risk. The majority of patients experienced symptom relief, and the success rate of stone removal was 86%. The authors concluded that routine use of antibiotics was not necessary for uncomplicated removal of these stones. [Extracted from the article]

Objectives: To compare the performance of ultrasonography with magnetic resonance imaging (MRI) and computed tomography (CT) for detecting submandibular sialoliths. Methods: Thirteen patients with suspected submandibular sialoliths who underwent ultrasonography and CT or MRI were included. Sialoliths were diagnosed using CT (11 cases) or MRI (two cases). The submandibular duct was classified into distal and proximal ducts based on the point around the mylohyoid muscle. Sialoliths located in the proximal duct were difficult to differentiate from those located within the submandibular gland (SMG). Therefore, the location of the sialoliths was classified as follows: within the SMG/proximal duct and within the distal duct. The ultrasound results were compared with CT/MRI results. Results: Of the 13 patients included, two had sialoliths in both the SMG/proximal duct and the distal duct, three had sialoliths in the SMG/proximal duct, and five had sialoliths in the distal duct on CT or MRI. In this small cohort, all five sialoliths in the SMG/proximal duct were detected by ultrasoonography; however, of the seven cases with sialoliths located in the distal duct, only three could be detected by ultrasonography. Conclusions: The incidence of sialoliths in the distal duct was higher than that in the SMG/proximal duct. Ultrasonography showed a good performance compared with CT/MRI in the SMG/proximal duct but not in the distal duct. [ABSTRACT FROM AUTHOR]

BackgroundSialolithiasis or salivary gland stones are associated with high clinical morbidity. The advances in the treatment of sialolithiasis has been limited, however, by our understanding of their composition. More specifically, there is little information regarding the formation and composition of the protein matrix, the role of mineralogical deposition, or the contributions of cell epithelium and secretions from the salivary glands. A better understanding of these stone characteristics could pave the way for future non-invasive treatment strategies.MethodsTwenty-nine high-quality ductal stone samples were analyzed. The preparation included successive washings to avoid contamination from saliva and blood. The sialoliths were macerated in liquid nitrogen and the maceration was subjected to a sequential, four-step, protein extraction. The four fractions were pooled together, and a standardized aliquot was subjected to tandem liquid chromatography mass spectrometry (LCMS). The data output was subjected to a basic descriptive statistical analysis for parametric confirmation and a subsequent G.O.-KEGG data base functional analysis and classification for biological interpretation.ResultsThe LC-MS output detected 6934 proteins, 824 of which were unique for individual stones. An example of our sialolith protein data is available via ProteomeXchange with the identifier PXD012422. More important, the sialoliths averaged 53% homology with bone-forming proteins that served as a standard comparison, which favorably compared with 62% homology identified among all sialolith sample proteins. The non-homologous protein fraction had a highly variable protein identity. The G.O.-KEGG functional analysis indicated that extracellular exosomes are a primary cellular component in sialolithiasis. Light and electron microscopy also confirmed the presence of exosomal-like features and the presence of intracellular microcrystals.ConclusionSialolith formation presents similarities with the hyperoxaluria that forms kidney stones, which suggests the possibility of a common origin. Further verification of a common origin could fundamentally change the way in which lithiasis is studied and treated.

OBJECTIVES: Sialendoscopy is a relatively new mini-invasive method that allows direct visualisation and intervention in the salivary gland ductal system. The aim of the study was to evaluate the results of sialendoscopy in the treatment of obstructive sialadenitis. MATERIALS AND METHODS: This is a 15-year retrospective study analysing the treatment results of patients treated in the period of 2007–2022 at the Department of Oral and Maxillofacial Surgery, Comenius University Bratislava, Slovakia. RESULTS: The total number of performed sialendoscopies was 70, of which 44 (62.9 %) were performed on the submandibular gland and 26 (37.1 %) on the parotid gland; 46 procedures (65.7 %) were performed via natural ductal system opening without the need for surgical assistance while 24 sialendoscopies (34.3 %) required surgical assistance. The most frequent perioperative findings were the sialoliths (37) in quantities ranging from one to four. Non-calculi pathologies (23) included mucous plugs, strictures, plaque, erythema or foreign bodies. No pathology was found on 10 sialendoscopies. In 82 % (n = 55) of patients, sialendoscopy prevented the salivary gland from being excised. In 18 % (n = 12) of cases, sialendoscopy findings indicated that salivary gland excision was needed. CONCLUSION: The study acknowledges the significant benefit of sialendoscopy in the treatment of obstructive sialadenitis. [ABSTRACT FROM AUTHOR]

Salivary stones (sialoliths) are calcified structures located in the ductal system of the major salivary glands. Their exact cause is not clear but in general they are characterized by concentric inorganic (hydroxyapatite) layers. The formation is a slow intermittent process which may result in enlargement of the sialolith causing obstruction of saliva secretion resulting in mealtime related pain and swelling of the affected salivary gland. Various studies reported the presence of organic material such as proteins and lipids in the core of sialoliths. In the present study the protein composition of twenty submandibular sialoliths was analyzed. It was found that proteins contributed on average 5% to the dry weight of submandibular stones whereby small salivary stones contained more extractable proteins than large salivary stones. Using a combination of SDS-PAGE gel electrophoresis and Western blotting, we identified α-amylase (in all stones; 100%), lysozyme (95%), lactoferrin (85%), secretory-IgA (75%), MUC7 (60%), complement C4 (60%) and C-reactive protein (35%). The presence, and the combinations, of lactoferrin, lysozyme, s-IgA and α-amylase in sialoliths was confirmed by ELISA. The gradually increasing size of a sialolith might provoke a local inflammatory response in the duct of the submandibular gland whereby the relatively low concentrations of lactoferrin and lysozyme may originate from neutrophils. The interaction of lactoferrin with s-IgA could contribute to the accumulation of lactoferrin in sialoliths. In summary, these results suggest a new pathophysiological role for lactoferrin, in the formation of sialoliths. [ABSTRACT FROM AUTHOR]

Relevance. The current limits of endoscopic removal of sialolithes are limited to 3-5mm, larger sialolithes require crushing, but an effective and safe technology has not yet been found. The solution to this problem is primarily related to the technologies of shock wave lithotripsy. Currently, various methods of lithotripsy using extracorporeal and intracorporeal sources are described in the literature. The positive experience of urological laser lithotripsy served as the basis for our study of the possibilities of using the thule laser device FiberLase U2 for the fragmentation of sialolithes. Materials and Methods. The study included 16 clinical observations of patients diagnosed with sialolithiasis who underwent sialoendoscopy with additional application of the technique of intra-c urrent crushing of the concretion with a thule laser device FiberLase U2 with subsequent extraction of fragments. Results and Discussion. Sialolithes were fragmented in all 16 clinical cases, regardless of shape and structure. Large fragments were removed using basket traps and endoscopic forceps. In 9 out of 16 observations, the operation ended with the complete removal of the stone and all its visible fragments (until the duct was completely cleaned). In 7 patients, fragments remained in the duct, which could not be removed. During the crushing process, we observed an undesirable effect of retrograde migration of the stone with a pulse impact, as well as the resulting suspension of small fragments and air bubbles complicated the visibility and the operation process. Also, in 3 cases, when the stone was destroyed, the laser beam hit the duct wall, which was accompanied by weak bleeding and for a while hindered endoscopic visibility and required active irrigation. Conclusion. At the first time, the technology of thule laser lithotripsy was used that made possible the destruction of sialolithes and remove stones larger than 5 mm. This approach expands the limits of endoscopic surgery of sialolithiasis. At the same time, there is a number of important problems that require further study and improvement of the method.

Sialolithiasis is a disease process involving the formation of conglomerates of calcifications in the ductal system or the parenchyma of the salivary gland. The Submandibular gland is more vulnerable to form sialoliths than the other major salivary glands due to its salivary composition and anatomic factors. The management of sialolithiasis is determined by the dimensions and position of the calculi. Here, we discuss a case of a twenty eight mm submandibular sialolith managed by an intraoral approach. [ABSTRACT FROM AUTHOR]

Sialoliths arising extraductally are rarely reported, particularly when large in size. Here we report a large calcified mass presenting in the submandibular region which proved difficult to locate with imaging. Clinical presentation findings can include pain, swelling (usually associated with eating), obstruction of the salivary duct and sialadenitis. A 71‐year‐old male was referred by his general dental practitioner to the Oral Surgery department regarding a 6‐month history of a firm painful swelling in the left floor of mouth. He had experienced only one episode of associated submandibular swelling which resolved spontaneously after a few days. A large, mobile, firm mass was palpable on clinical examination in the left lingual sulcus, which was slightly tender. There was no associated swelling palpable of the submandibular gland. Ultrasound imaging confirmed a calcified mass present of 18 mm in anteroposterior (AP) dimension which was not related to the submandibular duct or gland. Following recommendation from the Radiologist, a small field computed tomography (CT) scan was requested to locate the mass and determine its relationship to adjacent structures. CT findings confirmed a heavy calcified mass replacing much of the sublingual gland, with the absence of submandibular sialadenitis or duct dilation. The report raised a query of mucoepidermoid carcinoma so prompt excision to confirm the diagnosis was arranged accordingly. The patient recovered well following extraductal excision of the sialolith and marsupialisation of the submandibular duct under general anaesthesia. [ABSTRACT FROM AUTHOR]

Aim of the study: The present preliminary study aims to evaluate the possible positive outcomes of ultrasonography-guided sialolithotomies and duct stricture dilations utilizing stone retrieval baskets and guide wires. Case description: A total of 6 cases in an ongoing study (4 cases of sialolithiasis and 2 cases of duct strictures with intraluminal adhesion) were analyzed. All sialoliths were

Salivary gland disorder occurs commonly because of salivary calculi, which may occur at any age and involves any of the salivary glands. Most of the cases of sialolithiasis occur in the submandibular salivary gland as its duct is most prone to and common for acute and chronic infections. The symptoms include decreased or obstructed salivary flow. This case report presents a case of a patient with sialolithiasis of the submandibular gland and its treatment. It also includes etiology, signs and symptoms, diagnosis, and various treatment modalities.

Sialolithiasis is most commonly affects submandibular gland and duct due to its saliva content properties and anatomical location. The common size of sialolith is between 5mm and 10mm and it is called unusual in size when bigger than 10mm. The exact aetiology of its formation is still unknown. Typical presenting symptom is long history of fluctuating submandibular swelling which is associated with meal. Diagnosis is usually based on the history, clinical examination and supplemented by radiographic finding. Treatment is depending on size, location, and the number of stone. We present a case of unusual size of submandibular stone, 15mm x 5mm which is self-extruded by conservative management. [ABSTRACT FROM AUTHOR]

Published findings on the computed tomographic (CT) appearance of sialoceles are limited to brief descriptions from reported cases in eight dogs and one cat. The authors have seen sialoceles with CT characteristics that are not consistent with these previous reports. The purpose of this multicenter, retrospective, descriptive, case series study was to provide more detailed descriptions of the CT appearance of confirmed sialoceles in dogs. Dogs over a 10‐year period with cytologically or histologically confirmed sialoceles and pre‐ and postcontrast CT studies of the head were included. Multiple qualitative and quantitative features were described for each sialocele with histological correlation. Twelve dogs with a total of 13 sialoceles were identified, including: seven cervical sialoceles, three complex (combined cervical and sublingual) sialoceles, two sublingual sialoceles, and one zygomatic sialocele. All sialoceles were characterized by fluid attenuating, non‐contrast enhancing contents (median 18.5 HU) and soft tissue attenuating, contrast‐enhancing walls. The external margins of all sialocele walls were smooth; however, the internal margins in six sialoceles were irregular with poorly defined nodular to frond‐like protrusions. Mineralized foci of variable size (range < 1 mm to 4.8 mm) and attenuation (range 119 to 1253 HU) were present in seven sialoceles and histologically identified as sialoliths (three sialoceles) and osseous metaplasia (two sialoceles). A unique finding in the sialoceles in this study was the presence of intraluminal nodular to frond‐like protrusions arising from the wall. This study also reports the CT appearance of cervical and complex sialoceles and sialocele mineralizations. [ABSTRACT FROM AUTHOR]

Objective: This article discusses the clinical significance of an unusual case of the simultaneous occurrence of 2 giant sialoliths within the ipsilateral submandibular gland and distal aspect of Wharton's duct in a 63‐year‐old patient. Background: The majority of submandibular gland sialoliths are found in Wharton's duct, with fewer within the gland parenchyma. Giant sialoliths (exceeding 15 mm in size) are rare. Materials and methods: An asymptomatic, otherwise healthy older patient sought dental care and underwent a comprehensive oral and radiographic examination. Results: A panoramic radiograph revealed 2 incidental radiopaque structures, representing giant sialoliths within the submandibular gland and along the distal segment of Wharton's duct. This synchronous finding apparently represents the first case reported in the geriatric literature. Conclusions: The detection of 1 salivary stone should heighten the scrutiny for additional stones. Practitioners should carefully weigh the risk of sialolith removal versus deferment of treatment in older medically compromised patients. [ABSTRACT FROM AUTHOR]

In this case report, we detail a rare instance of sialadenitis secondary to bilateral hypertrophic torus mandibularis (TM) in a 70-year-old Caucasian male who presented with neck swelling, dysphagia, and weight loss. Radiographic evaluations revealed enlarged TM obstructing Wharton's duct, further complicated by a sialolith. The patient's treatment regimen included antibiotics, oral steroids, and sialogogues, accompanied by surgical removal of the hypertrophic TM and sialoendoscopy, which resulted in significant symptomatic relief and the resolution of sialadenitis. This case emphasizes the importance of recognizing mechanical etiologies in patients presenting with sialadenitis, particularly when linked to pronounced anatomical abnormalities like TM., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Basharat et al.)

Sialolithiasis is a condition that is characterized by the obstruction of the salivary gland duct opening by calcified mineral deposits due to various factors discussed in this case report. The most common symptom associated with the pathology is difficulty in deglutition, which can often lead to dehydration due to poor water intake. This, in turn further increases the viscosity of saliva which further promotes the formation of sialoliths. The management is dictated by the location and size of the sialolith, and in this case report, the significance of conservative treatment is emphasized while acknowledging the importance of invasive treatment when necessary., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Basra et al.)

Giant submandibular sialolithiasis is uncommon and sialoliths causing sialo-oral fistula are rare. We report a case of giant Wharton's duct sialolithiasis causing sialo-oral fistula in a 40 years male who presented with pain and swelling over right side of floor of mouth for more than two years and visualisation of yellow coloured stone like structure at floor of mouth in the last two days. With diagnosis of Submandibular gland sialolithiasis with sialo-oral fistula, sialolithotomy and marsupialization of Wharton's duct was done under local anaesthesia.

Objectives: Some calcifications of the head and neck region may be seen on dental panoramic images due to the superimpositions and proximity of structures. The aim of the present study was to evaluate the prevalence of soft tissue calcifications observed on digital panoramic images and the relationship of the calcifications with age and gender. Materials and Methods: Four thousand two hundred and sixty-three digital dental panoramic radiographs of the individuals aged between 6 and 89 who had visited the faculty of dentistry for different oral and dental complaints were evaluated retrospectively and detected calcifications were recorded with the age and gender information. Data were analyzed by means of descriptive statistics, Pearson Chi-squared, and independent samples t-test. Results: Two hundred and seventy calcifications (6.4%) were detected in the whole study population. Observed calcification types were tonsillolith (2.5%), carotid artery calcification (2.3%), sialolith (1%), and calcified lymph node (0.6%). The prevalence of calcifications for all types increased with age (P < 0.001). Conclusions: The prevalence of calcifications seen on the dental panoramic images is relatively rare, but the detection during routine dental examinations is important in terms of the need for more detailed evaluation of the patients.

Objectives: The present study was developed to evaluate the accuracy of in vivo ultrasound sizing for parotid and submandibular salivary gland calculi, as compared with ex vivo pathology sizing with a standard plastic ruler after extraction. Study Design: Retrospective chart review. Setting: Ultrasound is frequently used to size salivary calculi and make treatment decisions, but the accuracy of measurements from this modality has not been validated. Subjects and Methods: We evaluated and reviewed the charts and ultrasound examinations of 167 patients who underwent procedures for the treatment of sialolithiasis involving the parotid and submandibular glands. US examinations were performed between 2009 and 2016 in a tertiary-level hospital setting by the senior author. Measurements were collected from ultrasound evaluation before sialolithotomy, and pathology measurements were taken after removal. Ultrasound measurements in millimeters were compared with the measurements collected with a ruler. The differences were calculated and compared. Results: A total of 167 calculi measurements were compared. Good concurrent validity between pathology and ultrasound measurements was suggested by a Pearson correlation of 0.92 (95% CI, 0.887-0.937). On Bland-Altman plot, correlation of the difference between US and pathology measurements showed a mean difference of 0.095 mm (95% CI, –0.19 to 0.38 mm) with a limit of agreement ranging from –3.59 mm (95% CI, –3.84 to –3.34 mm) to +3.78 mm (95% CI, +3.53 to +4.03 mm). Conclusions: Ultrasound is an accurate, relatively precise, and minimally invasive imaging tool for salivary gland sialolithiasis. Preoperative size of calculi can be used to guide management and clinical decision making. Level of Evidence: 2C. [ABSTRACT FROM AUTHOR]

Sialolithiasis is one of the common diseases affecting the salivary glands. The submandibular gland is the most commonly affected gland among the three major salivary glands. The incidence of parotid sialolith is rare and when present, often demands surgical removal. Here, we report a rare case of a female patient presented with large sialolith indicated for surgical removal. However, surprisingly, it resulted in self-exfoliation eliminating the need for surgery as the patient had opted to wait.

Panoramic radiography is a useful screening tool for an array of dental and nonodontogenic disorders related to calcification as well as assessment of trauma and development of the oral and maxillofacial complex. Rotational movements of the radiographic source and detector plate may promote ghost image formation, particularly with larger radiopaque objects, and complicate the radiographic interpretation. This article describes cases of a giant submandibular gland sialolith and a giant tonsillolith, each of which appeared as a bilateral presentation due to contralateral ghost images, and discusses their clinical, demographic, and radiographic characteristics. Computed tomographic examinations were used to confirm the unilateral presentation of these objects and for determination of the extent of adjacent soft tissue impingement. Distinguishing an actual panoramic image from a ghost artifact may avoid unnecessary surgical intervention and improve clinical outcomes. [ABSTRACT FROM AUTHOR]

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Introduction: Sialolith is the most common condition of the salivary gland disorders after mumps, which usually occurs in the submandibular gland. A rare case of giant parotid sialolith is described. Case Report: A 58-years-old man with a complaint of swelling in the buccal area referred to the Department of Oral Medicine of the Dental School of Semnan University. A mild swelling was observed in the right cheek area in front of Ramus during the extraoral examination. Iintraoral evaluation revealed a 2.5 x 2 cm swelling with same color of the mucous membrane, adjacent to the maxillary first molar at the Parotid Papilla area, and with a stony-hard consistency. In the radiographic imaging, an estimated 18x6 mm homogenous opaque lesion was recognized; hence, the sialolith diagnosis was suggested. Surgical removal with electrocautery was done and no complaints were reported one month after the surgery. Conclusion: Since giant sialolith can lead to complications which may affect patients' quality of life, surgical treatment of such lesion is strongly recommended. [ABSTRACT FROM AUTHOR]

Sialolithiasis accounts for the most common cause of diseases of salivary glands. The majority of sialoliths occur in the submandibular gland or the Wharton's duct. Obstructive sialadenitis is the most frequent non-neoplastic salivary disorder with sialoliths being the main cause. This case report presents a case of a sialolith in the left Wharton's duct in an adolescent, which was diagnosed using radiographs and removed via a simple intra-oral approach. [ABSTRACT FROM AUTHOR]

Objectives: Sialolithiasis is the primary etiology for parotid and submandibular swelling, potentially resulting in discomfort, bacterial infections, and hospitalization. The etiology of sialolith formation is unknown. Currently, the proposed etiologies range from inflammation, coalescence of organic molecules, sialomicrolith formation, pH changes, and biofilm formation. In this study, we performed a descriptive analysis of images obtained through electron microscopy of sialoliths. Based on our findings and descriptive analysis, we hypothesize that sialolith formation is likely multifactorial and begins with biofilm formation. Biofilm formation then triggers a host immune response, and it is the interaction of biofilm with host immune cells and calcium nanoparticles that forms the nidus and creates a favorable environment for calcium precipitation.Methods: Sialoliths were extracted from patients and imaged under light and scanning electron microscopy. Specimens for light microscopy were prepared using a diamond saw. Specimens for electron microscopy were freeze-fractured, thus providing an undisturbed view of the core of the sialolith.Results: We were able to identify clear evidence of biofilm caves at the core of each sialolith. These biofilm caves were complex with the presence of bacteria and dehydrated extrapolysaccharide matrix, host cells (immune cells, platelets and erythrocytes), and calcium nanoparticles.Conclusion: The etiology of sialolith formation is likely multifactorial. We propose that biofilm formation within a single salivary gland or duct leads to local ductal injury, which results in the influx of host immune cells that interact with the biofilm and calcium nanoparticles, creating a scaffold upon which further calcium deposition can occur.Level Of Evidence: NA Laryngoscope, 130:69-74, 2020. [ABSTRACT FROM AUTHOR]

Our studies aimed to explore the protein components of the matrix of human submandibular gland sialoliths. A qualitative analysis was carried out based on the filter aided sample preparation (FASP) methodology. In the protein extraction process, we evaluated the applicability of the standard demineralization step and the use of a lysis buffer containing sodium dodecyl sulfate (SDS) and dithiothreitol (DTT). The analysis of fragmentation spectra based on the human database allowed for the identification of 254 human proteins present in the deposits. In addition, the use of multi-round search in the PEAKS Studio program against the bacterial base allowed for the identification of 393 proteins of bacterial origin present in the extract obtained from sialolith, which so far has not been carried out for this biological material. Furthermore, we successfully applied the SWATH methodology, allowing for a relative quantitative analysis of human proteins present in deposits. The obtained results correlate with the classification of sialoliths proposed by Tretiakow. The performed functional analysis allowed for the first time the selection of proteins, the levels of which differ between the tested samples, which may suggest the role of these proteins in the calcification process in different types of sialoliths. These are preliminary studies, and drawing specific conclusions requires research on a larger group, but it provides us the basis for the continuation of the work that has already begun.

Sialolithiasis is characterized by obstruction of a salivary gland or its duct due to the formation of calcareous concretions, leading to recurrent painful swelling of the involved gland. It is aggravated while eating. Submandibular gland is the most commonly affected gland. The size of the sialolith may range from 1 to 10 mm. Sometimes, the formation of sialo-oral or sialo-cutaneous fistula may promote the growth of the sialolith to a giant size of 15 to 20 mm. Giant sialolith of size greater than 20 mm is sparse in the literature. The purpose of this presentation is to report a case of an unusually large sialolith measuring 28 mm located in the left submandibular salivary gland of a 29-year-old male patient. [ABSTRACT FROM AUTHOR]

Objectives: To compare the performance of ultrasonography with magnetic resonance imaging (MRI) and computed tomography (CT) for detecting submandibular sialoliths., Methods: Thirteen patients with suspected submandibular sialoliths who underwent ultrasonography and CT or MRI were included. Sialoliths were diagnosed using CT (11 cases) or MRI (two cases). The submandibular duct was classified into distal and proximal ducts based on the point around the mylohyoid muscle. Sialoliths located in the proximal duct were difficult to differentiate from those located within the submandibular gland (SMG). Therefore, the location of the sialoliths was classified as follows: within the SMG/proximal duct and within the distal duct. The ultrasound results were compared with CT/MRI results., Results: Of the 13 patients included, two had sialoliths in both the SMG/proximal duct and the distal duct, three had sialoliths in the SMG/proximal duct, and five had sialoliths in the distal duct on CT or MRI. In this small cohort, all five sialoliths in the SMG/proximal duct were detected by ultrasoonography; however, of the seven cases with sialoliths located in the distal duct, only three could be detected by ultrasonography., Conclusions: The incidence of sialoliths in the distal duct was higher than that in the SMG/proximal duct. Ultrasonography showed a good performance compared with CT/MRI in the SMG/proximal duct but not in the distal duct., Competing Interests: All authors declare no conflicts of interest associated with this manuscript., (© 2023 Australasian Society for Ultrasound in Medicine.)

Objectives: For chronic obstructive sialadenitis, there is a paucity of long-term prospective evidence of disease-specific symptom outcomes after sialendoscopy-assisted salivary duct surgery (SASDS). We prospectively assessed patients with sialolithiasis before and at 3 months and 1 year after SASDS using the Chronic Obstructive Sialadenitis Symptoms (COSS) questionnaire.Methods: A prospective cohort study of adult patients with sialolithiasis who underwent SASDS and completed the COSS questionnaire over a 1-year follow-up period. The COSS questionnaire consists of 20 disease-specific symptom questions. COSS score outcomes were classified by complete, partial, and nonresolution, as well as by clinically significant improvement.Results: Ninety-six patients underwent SASDS in 110 glands, of which 69 glands (63%) had findings of sialolithiasis. The following median COSS scores were reported for sialolithiasis glands: preoperative, 27.5 (interquartile range [IQR]: 12.5-44); 3 months, 1 (IQR: 0-5); and 1 year, 1 (IQR: 0-5.5). Patients with sialolithiasis reported statistically significant improvements in COSS scores from preoperative to 3 months post-SASDS (P > 0.05). A vast majority of patients maintained this improvement from 3 months to 1 year, indicating durability. Complete resolution of symptoms was attained in 95% and 85% of glands at 3 months and 1 year, respectively. Open/hybrid compared to endoscopic-only sialolithiasis extraction achieved similar 3-month and 1-year COSS outcomes. Potential risk factors for symptom persistence after SASDS included nonreachable parenchymal sialoliths and concurrent inflammatory disease and/or stenosis.Conclusion: SASDS for sialolithiasis extraction is associated with durable, long-term benefit regardless of endoscopic or open technique or sialolith location, suggesting that subsequent ductal stenosis from iatrogenic or sialolithiasis-related inflammation fibrosis is unlikely.Level Of Evidence: 4 Laryngoscope, 129:396-402, 2019. [ABSTRACT FROM AUTHOR]

Amelogenesis imperfecta (AI) is a disease primarily affecting amelogenesis, but other various aberrations have been reported in association with this entity. Enamel-renal syndrome (ERS) is a very rare disorder associating AI with nephrocalcinosis. It is known by various synonyms such as AI nephrocalcinosis syndrome, MacGibbon syndrome, Lubinsky syndrome and Lubinsky–MacGibbon syndrome. The purposes of this article are to describe other dental anomalies which are rarely associated with AI making the diagnosis of AI a complex disorder and also to report a rare case of MacGibbon syndrome presented with sialolith of submandibular gland duct which is the first reported case in the literature. [ABSTRACT FROM AUTHOR]

Background/purpose: To our knowledge, sialolithiasis in minor salivary glands is very rare, and information about the disease is limited. The current study aimed to provide updated data regarding the disease in Taiwan. The data were compared with those of previous case series studies. Materials and methods: The features of 17 cases of histopathologically confirmed sialolithiasis in minor salivary glands between 1991 and 2015 in our institution were retrospectively analyzed. Results: Most of the patients were male (n = 14; 82.35%), with only three female patients (17.65%). The mean age of the 17 patients was 62.93 years (range, 35–82 years). Fifteen cases (∼88%) were found within the 6th–9th decades. Seven cases (∼41%) were identified in patients aged ≥70 years, six of which had been diagnosed in the most recent 5 years (2011–2015). The most common site was the buccal mucosa (n = 7; 41.18%), followed by the upper lip (n = 5; 29.41%), lower lip (n = 3; 17.65%), and vestibule and retromolar area (each n = 1; 5.88%). Only one case (5.88%) was clinically diagnosed as sialolithiasis prior to biopsy examination. Conclusion: The current study demonstrated an aging tendency and a male predilection of sialolithiasis in minor salivary glands in Taiwan when compared with published case series studies.

During sialoendoscopy, insertion of the endoscope through the ductal orifice is usually a challenging procedure, especially for beginners. Based on our experience, we have found that using the Kolenda Salivary Access Introducer Set is the most reliable and easily learned ductal access approach. We report details of the technique and discuss the advantages of this approach. [ABSTRACT FROM AUTHOR]

Background and objectives: Sialolithiasis is an inflammation of a salivary gland due to obstruction of salivary flow by a sialolith. We aim to assess potential factors that may predict lower morbidity following endoscopically assisted per-oral sialolith removal. Materials and Methods: Retrospective cohort study. Retrospective review of 100 records of patients with sialolithiasis, following surgical sialolith removal. A single medical center (Department of oral and maxillofacial surgery-Rabin Medical Center, Beilinson & Hasharon–Israel) survey. Data were gleaned from the patient files based on a structured questionnaire. Factors that may predict morbidity were evaluated using linear regression equation. Results: 59 of the subjects were men and 41 were women. The mean age of the patients in the study was 50 ± 17.5 years. Sialolith volume and past antibiotic treatment were positively associated while age was negatively associated with hospitalization duration. Conclusion: Early sialolith diagnosis and removal may lower postoperative morbidity.

Giant submandibular sialolithiasis is uncommon and sialoliths causing sialo-oral fistula are rare. We report a case of giant Wharton's duct sialolithiasis causing sialo-oral fistula in a 40 years male who presented with pain and swelling over right side of floor of mouth for more than two years and visualisation of yellow coloured stone like structure at floor of mouth in the last two days. With diagnosis of Submandibular gland sialolithiasis with sialo-oral fistula, sialolithotomy and marsupialization of Wharton's duct was done under local anaesthesia. [ABSTRACT FROM AUTHOR]

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In this series of cases, we highlight that a patient's reason for presentation may not always be as it seems. [ABSTRACT FROM AUTHOR]

Copyright of Revista ADM is the property of Asociacion Dental Mexicana and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Sialoliths are calcified organic matter that forms within the secretory system of the major salivary glands. Salivary gland calculi account for the most common disease of the salivary glands, and may range from tiny particles to several centimetres in length. It is the most common cause of acute and chronic infections. While the majorities of salivary stones are asymptomatic or cause minimal discomfort, larger stones may interfere with the flow of saliva and cause pain and swelling. We are presenting the case of 52 years old male patient complains of swelling on the right side of the face since 2 months. The majority of sialoliths occur in the submandibular gland or its duct; here we are presenting a case of parotid glands with emphasis on diagnostic aids.