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4 results on '"Si-Fan Gao"'

3. LC3B in Malignant Cells Correlates With Immune Infiltrate in Hypopharyngeal Squamous Cell Carcinoma

Author

Dangjun Wei, Chaobing Gao, Zhengsheng Wu, Jun Chen, Xiaowen Han, and Si-Fan Gao

Subjects
Male, Cancer Research, Cellular immunity, autophagy, Gene Expression, Kaplan-Meier Estimate, Immunoglobulin light chain, lcsh:RC254-282, Immunophenotyping, 03 medical and health sciences, 0302 clinical medicine, Immune system, Lymphocytes, Tumor-Infiltrating, Tumor-Associated Macrophages, Cytotoxic T cell, Humans, LC3B, Neoplasm Metastasis, 030304 developmental biology, Neoplasm Staging, 0303 health sciences, CD39, hypopharyngeal squamous cell carcinoma, Chemistry, Squamous Cell Carcinoma of Head and Neck, Autophagy, CD8, Prognosis, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Immunohistochemistry, Oncology, 030220 oncology & carcinogenesis, Cancer research, Female, Original Article, CD163, immune cell, MAP1LC3B, Microtubule-Associated Proteins, Biomarkers
Abstract

The objective of this study was to investigate the between autophagy activity and local immune response in hypopharyngeal squamous cell carcinoma (HSCC). Herein, we observed the expression of autophagy marker microtubule-associated protein light chain 3B (MAP1LC3B), CD8 cytotoxic T lymphocytes (CTLs), CD39 (regulatory T cells Tregs) and CD163 (tumor-associated macrophages TAMs) in HSCC, and determined the prognostic roles of CD8+/CD39+ and CD8+/CD163+ in patients with HSCC. The expression of light chain 3B (LC3B) and CD8+/CD39+ was found to be significantly lower in HSCC tissues than in adjacent non-tumor mucosa tissue samples; LC3B expression was positively correlated with the infiltration rate of CD8+/CD39+ in HSCC. Further studies revealed that the ratio of CD8+/CD39+ immune cells was negatively correlated with tumor lymph node metastasis and TNM classification, while the ratio of CD8+/CD163+ immune cells was negatively correlated with TNM classification. Moreover, the expression of LC3B was analyzed and the patients were grouped according to their immune infiltration characteristics. The 5-year cumulative survival rates of LC3B+, CD8+/CD39+, and CD8+/CD163+ patients were significantly higher than those of other group patients. Collectively, our studies indicated that the expression of LC3B in HSCC was correlated with the infiltration ratio of immune cells, and a change in autophagy activity may affect the cellular immunity in HSCC. The ratios of tCD8+/CD39+ and tCD8+/CD163+ may serve as prognostic factors for HSCC.

Published
2020

4. The long-term impact of expansion sphincter pharyngoplasty treatment on blood pressure control and health-related quality of life in patients with obstructive sleep apnea and hypertension

Author

Si-Fan Gao, Hongting Hua, Dong Wang, Y H Liu, Jun Chen, Yun-Xia Ma, and Chao-Bing Gao

Subjects
Adult, Male, medicine.medical_specialty, Ambulatory blood pressure, Neurology, medicine.drug_class, Diastole, Obstetric Surgical Procedures, Comorbidity, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Internal medicine, Outcome Assessment, Health Care, medicine, Humans, Antihypertensive drug, Antihypertensive Agents, Aged, Sleep Apnea, Obstructive, business.industry, Middle Aged, medicine.disease, Combined Modality Therapy, Obstructive sleep apnea, Blood pressure, medicine.anatomical_structure, 030228 respiratory system, Otorhinolaryngology, Hypertension, Cardiology, Quality of Life, Sphincter, Pharynx, Female, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

To assess how expansion sphincter pharyngoplasty (ESP) impacts blood pressure (BP) and health-related quality of life (HRQOL) in hypertensive patients with obstructive sleep apnea (OSA). Patients were separated into two groups based upon whether or not they adhered to antihypertensive drug regimens. Patients underwent 24-h ambulatory BP monitoring before and at 6 months post-ESP, while clinical BP measurements and HRQOL questionnaires (SF-36) were conducted over the course of 24 months post-surgery. We enrolled 62 patients, with 25 and 37 in the medicated and non-medicated groups, respectively. Mean 24-h BP differed significantly, with systolic and diastolic BP (SBP and DBP) decreases of 5.3 mmHg and 2.5 mmHg, respectively (P

Published
2020

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