Search

Healthcare providers rely on complex biomedical devices to assess, treat, and monitor patients. Ongoing research efforts are attempting to generate and implement better algorithms and mechanisms to ensure the early, accurate, automated, and clinically meaningful recognition of patterns and changes in patient health and pathology. Effecting such evolutionary advances in patient monitoring will likely require large collections of high-resolution physiologic parameter datasets from a broad spectrum of patients. As part of a research program to scientifically improve patient monitoring (with a focus on alarm fatigue mitigation), investigators developed the Medical Technology Interface-Open/Research toolkit with modular conduit components that provide the following capabilities: 1) access to select bedside monitor physiologic signals in real-world clinical settings for near-real-time acquisition, storage, and export of high-resolution patient datastreams in a portable format (.json); 2) establishment of a safe, parallel test environment at the bedside for experimental datastream analyses in a research framework. Deployment and interfacing of toolkit elements with off-the-shelf software solutions in a live emergency department setting enabled the construction of a bedside clinical informatics (BCI) research pipeline infrastructure that featured 1) indexing, search/query, and retrieval of datastreams for sophisticated analyses, experimental processing, and algorithm development; and 2) dataset visualization for expert adjudication of datastream interpretability, alarm clinical significance and severity, and experimental algorithm performance. In order to help institute a collaborative biomedical engineering research resource, this article shares details of the active ED BCI data pipeline and presents preliminary examples of ongoing multimodal data fusion applications.

Background: Current induced in a guidewire during papillotomy poses a danger of injury to the bile duct. We measured currents induced in three commercially available guidewires and a prototype fiberglass wire during simulated sphincterotomy under standard and nonstandard conditions. Methods: Blended current at 55 W was applied to a double-lumen papillotome grounded through a 1000 Ω resistor. For extreme conditions, power was increased to 70 W using a single-lumen papillotome. Fault conditions were created with a break in the insulation at the distal end of each wire. Guidewire-induced current was measured, and safety calculations performed for adherence to accepted standards for electrosurgical devices. Results: Induced current was within safety limits for all wires tested under standard conditions. With insulation faults, one of the commercially available wires was unsafe. Under extreme conditions, with or without faults, the three commercial wires produced currents ranging from 9% to 225% above acceptable levels, while only the prototype wire remained safe. Conclusions: Most guidewires contain metal cores that function as capacitors. Because its core is primarily fiberglass, the prototype wire generates less induced current under nonstandard conditions, thus achieving a greater margin of safety during wire-guided sphincterotomy. (Gastrointest Endosc 1997;45:493-7.)