1. A New Lipoxygenase Inhibitory Flavonoid from the Kino of Eucalyptus citriodora
- Author
-
Shwu-Woan Lee
- Subjects
chemistry.chemical_classification ,biology ,010405 organic chemistry ,Stereochemistry ,Flavonoid ,Plant Science ,General Chemistry ,01 natural sciences ,General Biochemistry, Genetics and Molecular Biology ,Cinnamic acid ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,Lipoxygenase ,chemistry ,Eucalyptus citriodora ,Caffeic acid ,biology.protein ,Gallic acid ,Quercetin ,IC50 - Abstract
A new lipoxygenase inhibitory flavonoid, 8-[1-(p-hydroxyphenyl)ethyl]rhamnocitrin (1), together with four known compounds, cinnamic acid (2), p-coumaric acid (3), caffeic acid (4), and gallic acid (5), was isolated from the kino of Eucalyptus citriodora, and their structures were elucidated on the basis of spectroscopic methods including 2D NMR spectra. These compounds were tested for inhibitory activity against 15-lipoxygenase. Compound 1 showed stronger inhibitory activity (IC50 27.6 ± 0.7 μM) than the positive control quercetin (IC50 37.5 ± 0.8 μM).
- Published
- 2019
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