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Abstract To analyze the clinical characteristics and to improve clinicians’ understanding of multiple pulmonary sclerosing pneumocytoma (PSP) patients. A total of 36 PSP patients with multiple tumor characteristics were identified from the literature search. They were compared with 43 solitary PSP patients diagnosed and treated in our hospital in the past 5 years. Thus, the pathogenesis, clinical symptoms, diagnosis methods, treatment strategies, and prognosis of pulmonary sclerosing pneumocytoma (PSP) patients with multiple tumors were explored. Patients with multiple PSP are mostly distributed in Asia (88.89%) and are females (83.33%). PSP can be located in any one lobe (19.44%), or grow across ipsilateral lobes (44.44%), or even, bilateral lobes (36.11%). It can be accompanied by metastasis (9.09%) and is prone to misdiagnosis (27.78%). Compared with solitary PSP, the occurrence age of multiple PSP was younger (mean ± standard deviation [SD]: 40.36 ± 18.12: 51.28 ± 12.74 years), but there was no significant difference in sex, tumor size (mean ± SD: 43.54 ± 46.18: 30.56 ± 17.62 mm), or symptoms. Individualized surgical resection is required for treatment, including pneumonectomy (17.65%), lobectomy (23.53%), subpulmonary lobectomy (38.24%), or combined lobectomy (5.88%). Multiple PSP is relatively rare. Surgical resection within a limited time should be the main treatment for such patients. The prognosis of patients with multiple PSP is generally good, but inappropriate diagnosis and treatment plans may lead to poor prognosis.

Atherosclerosis is associated with inflammation in the arteries, a significant cause of heart attacks and strokes. Although statin therapy can reduce the chances of atherosclerotic plaque formation, they need to be administered in high doses due to low systemic bioavailability and encountered with side effects. To overcome these challenges, we developed nanoparticles using biocompatible and biodegradable lipids and polymers for improving systemic drug absorption and therapeutic response. The polymeric nanoparticles were prepared using PLGA and PVA, while hybrid nanoparticles were prepared using PLGA and Phospholipon 90 G. Both nanoparticles were systematically optimized by I-optimal response surface design. The optimum formulation composition exhibited particle size of less than 250 nm, polydispersity index of less than 0.3, entrapment efficiency of more than 70%, and sustained drug release up to 6 h. In vivo pharmacokinetic evaluation in rats indicated multi-fold improvement in the extent of drug absorption (Cmax and AUCtotal) for atorvastatin from the nanoparticles vis-à-vis the pure drug suspension. In vivo pharmacodynamic studies also indicated the excellent ability of nanoparticles to lower the elevated levels of lipids (total cholesterol, triglycerides, and low-density lipoproteins) and increase the level of high-density lipoproteins as compared to that of the pure drug suspension.

Soil heavy metal pollution has become a major ecological and environmental problem and a serious threat to global food security. Organic fertilizer can not only improve soil quality and provide nutrients for plants but also reduce the harm of heavy metal ions to a certain extent, meaning it has become a current research hotspot in the field of heavy metal passivation. In this paper, a completely combined experimental design was used to compare the effects of five organic fertilizers [nutshell organic fertilizer (NOF), pig manure organic fertilizer (PMOF), sludge organic fertilizer (SOF), humus soil organic fertilizer (HSOF) and earthworm soil organic fertilizer (ESOF)] on available Cd in soil with different pollution levels at different dosages, and the passivation mechanism of soil Cd was preliminarily discussed. The results showed that all kinds of organic fertilizers were passivated by reducing the Cd availability, and their effects on the Cd availability of purple soil were closely related to the degree of soil pollution and the amount of organic fertilizers. The passivation effect of moderate Cd-contaminated soil was the best, which increased with the increase of organic fertilizer application rate, and the effects of NOF and SOF were the best. However, the passivation effect of organic fertilizers on soil Cd was the worst in mild Cd-contaminated soil, especially ESOF. The results of Cd morphological correlation analysis showed that Exe-Cd and FeMnOx-Cd in the soil had significantly positive contributions to available Cd, while Res-Cd showed significantly negative contributions. And in moderate Cd contaminated soil, Exe-Cd content decreased by 7.12%–28.50%, while Res-Cd content increased by 19.74%–65.81%. In addition, the content of available Cd in soil decreased first and then increased with time after adding organic fertilizer, and reached the lowest value at 15 days and stabilized after 60 days. The conclusion of this paper can provide a theoretical basis for the rational use of organic fertilizer to reduce the bioavailability of cadmium in Gray-Purple soil.

With the development of intelligent ship, types of advanced sensors are in great demand for monitoring the work conditions of ship machinery. In the present work, a self-powered and highly accurate vibration sensor based on bouncing-ball triboelectric nanogenerator (BB-TENG) is proposed and investigated. The BB-TENG sensor consists of two copper electrode layers and one 3D-printed frame filled with polytetrafluoroethylene (PTFE) balls. When the sensor is installed on a vibration exciter, the PTFE balls will continuously bounce between the two electrodes, generating a periodically fluctuating electrical signals whose frequency can be easily measured through fast Fourier transform. Experiments have demonstrated that the BB-TENG sensor has a high signal-to-noise ratio of 34.5 dB with mean error less than 0.05% at the vibration frequency of 10 Hz to 50 Hz which covers the most vibration range of the machinery on ship. In addition, the BB-TENG can power 30 LEDs and a temperature sensor by converting vibration energy into electricity. Therefore, the BB-TENG sensor can be utilized as a self-powered and highly accurate vibration sensor for condition monitoring of intelligent ship machinery.

The development of artificial intelligence technology has brought changes to various industries. Under the concept of green sustainable development, how to use the progress of science and technology to implement low-carbon strategies is a problem that every enterprise should consider. Aiming at the problem of picking up goods in logistics industry, this paper proposed a secondary task assignment theory for multiple unmanned aerial vehicle (Multi-UAV) based on green scheduling. The theory greatly improves the utilization rate of unmanned aerial vehicle (UAV) and reduces the energy consumption. We analyzed the advantages and disadvantages of local optimal algorithm and global optimal algorithm in time and energy consumption. Through repeated experiments in different ranges, we have well verified the high efficiency and general applicability of this theory, which can provide theoretical and practical implications for logistics enterprises using UAV to achieve low-carbon sustainable development in the future.

Abstract Background Interferon-γ (IFN-γ) is critical for innate and adaptive immunity against viral and bacterial infections. IFN-γ reportedly affects the phagocytic ability of monocytes and macrophages as well as regulates pituitary function in humans and mice. The present study analyzed the impact of IFN-γ on monocyte and macrophage phagocytosis, production performance, and pituitary function in vivo and in vitro (in dwarf chickens). IFN-γ was injected into dwarf chickens through a vein, and then, the laying rate, average egg weight, and levels of follicle-stimulating hormone (FSH) and IFN-γ were measured in treatment and control groups. For the in vitro experiment, the pituitary tissues were supplemented with IFN-γ, and the mRNA expression levels of follicle-stimulating hormone beta subunit (FSH-β), interferon gamma receptor 1 (IFNGR1), and interferon gamma receptor 2 (IFNGR2) in the pituitary were assessed. Results Monocyte and macrophage phagocytosis product (PP) was decreased by IFN-γ treatment in a dose-dependent manner in vitro. In the in vivo experiment, the level of IFN-γ in the treatment group was higher than that in the control group at 7 d (P

Long-chain fatty acyl-CoA synthetase (ACSLs) is an essential enzyme for the synthesis of fatty acyl-CoA. ACSL1 plays a key role in the synthesis of triglycerides, phospholipids, and cholesterol esters. Background: In the current study, triglyceride content did not increase after overexpression of the ACSL1 gene. Methods: RNA-seq and lipid metabolome profiling were performed to determine why triglyceride levels did not change with ACSL1 overexpression. Results: Fatty acyl-CoA produced by ACSL1 was determined to be involved in the diglyceride synthesis pathway, and diglyceride content significantly increased when ACSL1 was overexpressed. Moreover, the arachidonic acid (AA) content in sheep adipocytes significantly increased, and the level of cyclooxygenase 2 (COX2) expression, the downstream metabolic gene, was significantly downregulated. Knocking down the ACSL1 gene was associated with an increase in COX2 mRNA expression, as well as an increase in prostaglandin content, which is the downstream metabolite of AA. Conclusions: The overexpression of the ACSL1 gene promotes the production of AA via downregulation of COX2 gene expression.