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1. Activation of the Notch1-c-myc-VCAM1 signalling axis initiates liver progenitor cell-driven hepatocarcinogenesis and pulmonary metastasis

Author

Wen-Rui Wu, Xiang-De Shi, Fa-Peng Zhang, Ke Zhu, Rui Zhang, Xian-Huan Yu, Yu-Fei Qin, Shun-Peng He, Hou-Wei Fu, Lei Zhang, Hong Zeng, Man-Sheng Zhu, Lei-Bo Xu, Ping-Pui Wong, and Chao Liu

Subjects
Cancer Research, Carcinoma, Hepatocellular, Lung Neoplasms, Carcinogenesis, Cell Line, Tumor, Stem Cells, Liver Neoplasms, Genetics, Animals, Humans, Receptor, Notch1, Molecular Biology, Rats
Abstract

The cellular origin of hepatocellular carcinomas (HCC) and the role of Notch1 signalling in HCC initiation are controversial. Herein, we establish Notch1 as a regulator of HCC development and progression. Clinically, high Notch1 expression correlates with enhanced cancer progression, elevated lung metastasis, increased cancer stem cell (CSC)-like cells' gene signature expression, and poor overall survival in HCC patients. Notch1 intracellular domain (N1ICD) overexpression spontaneously transforms rat liver progenitor cells (LPC) into CSC-like cells (WB

Published
2022
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