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BACKGROUND: Middle cerebral artery (MCA) occlusion is extremely common, especially unilateral artery, which can result in a significant incidence of cerebral infarction. OBJECTIVE: To assess the value of whole-brain computed tomography perfusion (CTP) imaging combined with dynamic CT angiography (dCTA) in the evaluation of pial collateral circulation in patients with MCA occlusion. METHODS: Whole-brain CTP and dCTA images were acquired in 58 patients with unilateral MCA occlusion. All patients were divided into three groups according to the American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology (ASITN/SIR) collateral score (by CTA). The CTP parameters were analysed, including relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), relative mean transit time (rMTT), and relative time to peak (rTTP). Patients were followed up with the modified Rankin scale (mRS). All cases in this study were confirmed by DSA. RESULTS: The CTP parameters of the MCA blood supply area on the affected side of patients with different degrees of stenosis were significantly different from those on the unaffected side. There are significant differences in the CTP parameters and openings of the Willis circle in patients with different degrees of stenosis. Significant differences were found in the number of patients with good prognosis. CONCLUSIONS: Whole-brain CT perfusion combined with dynamic CTA can structurally and functionally evaluate the establishment of pial collateral circulation and its effect on cerebral hemodynamic changes.

OBJECTIVE: To compare the spectral computed tomography (CT) imaging parameters between squamous cell carcinoma (SCC) and adenocarcinoma (AC) at the gastroesophageal junction (GEJ). METHODS: A total of 80 patients were enrolled in this retrospective study. Among them, 35 were diagnosed with SCC (SCC group) and 45 were diagnosed with AC (AC group). All patients underwent an enhanced scan with spectral CT. The following CT imaging parameters were evaluated: iodine concentration (IC), water content (WC), effective atomic number (Eff-Z) and slope of the spectral HU curve (λHU) of lesions. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of spectral CT imaging parameters for diagnosis of SCC and AC. RESULTS: Patients with SCC had lower IC, Eff-Z, and λHU in arterial phase and venous phase compared with AC (p< 0.05). There were no significant differences in WC between the two groups. ROC curve analyses revealed that IC, Eff-Z, and λHU in arterial phase and venous phase were predictors for diagnosis of SCC and AC (AUC > 0.5). Moreover, the IC, Eff-Z and λHU in venous phase had better differential diagnostic performances than that in arterial phase. CONCLUSIONS: Spectral CT could be useful in the differential diagnosis of SCC and AC at the GEJ. Therefore, a routine spectral CT scan is recommended for patients with carcinoma of the GEJ.

Objective To observe the role of ultrasound biomicroscopy(UBM)in two-year post-operative follow-up for primary open-angle glaucoma patients with modified CO

Circular RNA (circRNA) is a type of closed circular RNA molecules formed by reverse splicing, which exists widely in organisms and has become a research hotspot in non-coding RNAs in recent years. Skeletal muscle plays the role of coordinating movement and maintaining normal metabolism and endocrine in organisms. With the development of sequencing and bioinformatics analysis technology, the functions and regulation mechanisms of circRNAs in skeletal muscle development have been gradually revealed. In this review, we summarize the types of molecular regulatory mechanisms, the classical research ideas and the functional research methods of circRNAs, and the research progress of circRNAs involved in normal development of skeletal muscle and regulation of skeletal muscle disease, in order to provide a reference to further study of the genetic mechanisms of circRNAs in the regulation of skeletal muscle development.环状RNA (circular RNA, circRNA)是一类反向剪接形成的闭合环状RNA分子,广泛存在于生物体内,近年来成为非编码RNA中的研究热点。骨骼肌在生物体中起到协调运动的作用,是维持体内正常代谢和内分泌的器官之一。随着测序技术和生物信息学分析技术的发展,circRNA在动物骨骼肌发育中的功能和调控机制逐渐被揭示。本文就当前circRNA的分子调控机制类型、circRNA经典研究思路及功能研究方法以及circRNA参与骨骼肌正常发育与骨骼肌疾病发生调控的研究进展进行了综述,以期为进一步深入研究circRNA参与骨骼肌生长发育调控的遗传机制以及circRNA相关研究方法提供参考。.

As it is well known, proper exercise benefits our mind and body, especially the skeletal muscle. Exercise increases the capacity of muscle metabolism, enhances the biological function of mitochondria, regulates the transformation of muscle fiber types and increases the muscle power. In recent years, more and more researches show that epigenetic regulation plays an important role in strengthening the muscle, and these studies mainly include DNA methylation, histone modification, and regulation of miRNA expression. In order to adapt to the body movement, these three epigenetic patterns change the metabolic capacity of skeletal muscle, mitochondrial biological function and muscle fiber types by regulating the gene expression of skeletal muscle. In this review, we summarize research progresses of exercise-induced epigenetic regulation of gene expression of skeletal muscle, in order to provide a reference for further studies of how sports improve our body health.

Enhancers are key cis-acting gene regulatory elements in eukaryotes, which can effectively promote the expression of target genes. Emerging evidence showed that enhancers in activation state could be transcribed to enhancer RNAs (eRNAs), the processes of which are regulated by various signaling systems and actions of signal-dependent transcription factors. Compared with the other transcripts (e.g. lncRNA, mRNA), eRNAs have shorter sequences, lower stability, and higher tissue specificity. eRNAs play roles in the initiation or stabilization of enhancer-promoter looping, and promote the expression of target genes. Recent studies have further showed that eRNAs have crucial roles in biological processes, such as development and disease initiation and progression. However, functional studies of eRNAs are currently lacking, and the regulatory mechanisms of eRNAs are still uncertain. Herein, we focus on the features, research methods and functional properties of eRNAs, and discusse the possibility of using eRNAs as therapeutic targets. We hope this discussion might provide some insights for further research on eRNAs.

According to requirements of lubrication points and characteristics of grease, a distributed intelligent lubrication system of wind turbines is presented in this paper. PLC+SCU is the major control part in this system. It is adopted communication mode between PLC and SCU, so the system has better expansibility, which can simultaneously lubricate more classified points of wind turbines. PLC has more reserved interface sources and can completely supply grease at long distance. Monitor and protect circuits are devised in this system, and these parts can inspire, locate and alert the fault when the failure in pipelines or operator system is occurred. This paper introduces the structure, principle and its’ control system of lubrication system for wind turbines in detail, and the usability of the system is analyzed and some practical equipments are shown on.

With the development of economy in recent years, rapid growth of electricity demand, the cooling and heating load gets more and more big proportion of the total electricity load; the power load is influenced by meteorological factors which become more and more big. This topic will be based on short-term load forecasting in ANN (Artificial Neural Networks), conduct further research on the relationship between meteorological factors and power load, find the impact of the core meteorological factors of power load, and linear core meteorological factor model to establish the suitable for load forecasting based on ANN, make the forecasting to correctly reflect the meteorological conditions, improve the prediction accuracy of short-term load forecasting.

Wind power system reactive power optimization problem is a very complicated nonlinear programming problem, using the traditional reactive power optimization algorithm such as nonlinear programming method, the genetic method, particle swarm algorithm, etc; it's easy to have a slow convergence speed, into a local optimal solution of problem. To solve these problems, we improve algorithm accordingly. According to the actual situation of wind power system, adjust the parameters, especially the number of artificial fish and vision for the dynamic testing, the selection, crossover and mutation in the number of artificial fish for debugging, in order to achieve satisfactory effect.

The hollow-triangle fiber is a novel profiled fiber. Its cross-sectional shape and shape factor index were obtained by a microcomputer image acquisition system, with a polarization capability and image analysis software. The shape factors of the fiber, such as shape factor in radius, shape factor in cross-section, branch factor and volume content were tested. The cross-section shape of cross-hollow fiber was compared with that of the hollow fiber. After that, a novel method about equivalent diameter was proposed to evaluate the characteristic shape coefficient. The method possesses many merits such as rapid, simple, accurate, convenient and thus being of great practical value.

The hollow-triangle PA6 composite shaped fiber produced by high-speed spinning with semi-dull polyamide 6 chips was designed and developed in our lab. Both the morphological structure and the rebound resilience of the fiber were observed and analyzed. Meanwhile, the weak acid, neutral and disperse dyes were applied to in the dyeing test. The results showed that the hollow-triangle fiber had a high degree of profile and good bulkiness. Furthermore, the immediate elastic recovery and total elastic recovery rate of the fiber were large. When stretched by 5%, the immediate elastic deformation of this fiber was 86.4% and its elastic recover rate was up to 100%, which is obviously better than that of the general PA6 fiber. Besides, the dyeing ability of the hollow-triangle PA6 fiber was nearly the same as that of the general one when it was dyed with different dyes under the normal technical conditions.

The relationship between properties of BF-WPC and the content of BF were studied, when wood-plastics composite (WPC) was reinforced by 12 mm and 3 mm short basalt fiber (SBF). The results showed that there may have some uneven distributions of SBF in WPC, when the content of 12 mm BF exceeded 30%. Restricted to the uneven distribution and the quantity of “end weak’’, it formed the close comprehensive property of BF-WPC by the length of 12mm and 3mm BF. The comprehensive property of BF-WPC has a maximum range of 15%-30% of the content of 12 mm BF. Compared to pure WPC, the tensile and bending strength of BF-WPC have improved. However, the reinforce effect of BF-WPC is different and is dependent on the index of each property. The BF-WPC plate can be developed with different properties and be a cost-effective material by choosing different length and content of BF.

Satellite cell is a kind of myogenic stem cells, which plays an important role in muscle development and injury repair. Through proliferation, differentiation and fusion of muscle fiber can satellite cells make new myonuclear, leading to the hypertrophy of skeletal muscle and fiber type transformation, and this would further affect the meat quality. Here, we review the relationship between muscle fiber development and meat quality attributes as well as the influence of the satellite cell differentiation on muscle fiber character. Besides, we also summarize the classical signaling pathway (i.e., Notch etc.) and influence of epigenetic regulation (i.e. miRNA) on muscle quality.

Objective: To investigate the clinical effect of Rhinitis Spray (RS) in treating chronic simple and hypertrophic rhinitis.Methods: Eighty patients with chronic rhinitis were divided into three groups and treated with RS, ephedrine and normal saline respectively.Results: The short-term effective rate in the three groups was 89.3%, 66.7% and 8.0% respectively. RS was effective in alleviating symptoms, increasing IgG level in nasal discharge, improving ventilatory function of nasal cavity and transfer function of nasal muosa cilia obviously.Conclusion: The therapeutic effect of RS in treating chronic rhinitis is satisfactory.

Intraocular pressure (IOP) is a elementary data in diagnosis and therapy of glaucoma. Many studies have confirmed that most tonometry, including Goldmann applanation tonometry, are influenced by central corneal thickness (CCT) and CCT varies greatly among the general population. As a result, the measurement of CCT has a great implication in management of glaucoma. Further, CCT is confirmed a risk factor for progression from ocular hypertension to primary open angle glaucoma. The idea of that CCT may bear an inverse relation with the risk for developing glaucoma damage is in debating. Many specialists bring forward that CCT measurement should be one of the regular examinations in treatment of glaucoma patients.

The epidemiological characteristics of Sjogren syndrome (SS) are significantly varied in different countries. We conducted the present study to survey the epidemiological characteristics of primary SS in China. We recruited 483 primary SS patients from 16 Chinese medical centers nationwide from January 2009 to November 2011 and assessed salivary and lacrimal gland dysfunction, organ involvement, and autoimmunity in these patients. The cohort included 456 women and 27 men (ratio, 17:1; mean age at onset, 42 ± 11 years; median age at diagnosis, 49 years; range, 41–56 years). Male patients showed a lower frequency of xerophthalmia (37.0% vs 60.7%) and a higher frequency of arthritis (40.7% vs 16.4%). Young-onset patients showed a higher frequency of low C3 levels (57.7% vs 36.3%) and pancytopenia (22.2% vs 8.8%). Patients with systemic involvement had a higher frequency of immunoglobulin A (IgA) (39.4% vs 22.5%) and immunoglobulin M (IgM) (12.4% vs 37.9%). Patients with pulmonary involvement had a higher parotid enlargement (21.4% vs 10.2%), purpura (12.1% vs 5.7%) and higher anti-La/SS-B (61.7% vs 41.8%), immunoglobulin G (IgG) (80.7% vs 64.6%) and IgA (48.9% vs 30.6%) levels. Patients with anti-Ro/SSA antibodies had more frequent exocrine gland symptoms and some extraglandular symptoms and immunological alterations. Compared with previous studies performed in other countries, SS patients in China showed particular clinical manifestation, systemic involvement, and immunological alterations.