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422 results on '"Shuman, H."'

3. Intracellular Multiplication of Legionella pneumophila: Human Pathogen or Accidental Tourist?

Author

Shuman, H. A., Purcell, M., Segal, G., Hales, L., Wiater, L. A., Compans, R. W., editor, Cooper, M., editor, Hogle, J. H., editor, Ito, Y., editor, Koprowski, H., editor, Melchers, F., editor, Oldstone, M., editor, Olsnes, S., editor, Potter, M., editor, Saedler, H., editor, Vogt, P. K., editor, Wagner, H., editor, Vogt, Peter K., editor, and Mahan, Michael J., editor

Published
1998
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4. Legionella pneumophila Invasion of Mononuclear Phagocytes

Author

Shuman, H. A., Horwitz, M. A., Compans, R. W., editor, Cooper, M., editor, Koprowski, H., editor, Melchers, F., editor, Oldstone, M., editor, Olsnes, S., editor, Potter, M., editor, Saedler, H., editor, Vogt, P. K., editor, Wagner, H., editor, and Miller, Virginia L., editor

Published
1996
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11. Generation and characterization of monoclonal antibodies to alveolar type II cell lamellar body membrane

Author

Zen, K., Notarfrancesco, K., Oorschot, V., Slot, J.W., Fisher, A.B., and Shuman, H.

Subjects
Monoclonal antibodies -- Physiological aspects, Proteins -- Physiological aspects, Lungs -- Physiological aspects, Rats -- Physiological aspects, Biological sciences
Abstract

A study was conducted to examine the production and characterization of monoclonal antibodies to alveolar type II cell lamellar body membranes. Lamellar bodies were obtained from rat lungs which had been cleared of blood while elastase digestion was utilized to isolate alveolar type II cells. Results indicated that the lbm180 protein is a lung lamellar body protein. Findings also showed that secretory granules from various tissues accommodated a number of common features.

Published
1998

14. Pathways for uptake of fluorescently labeled liposomes by alveolar type II cells in culture

Author

Muller, W.J., Zen, K., Fisher, A.B., and Shuman, H.

Subjects
Liposomes -- Physiological aspects, Pulmonary surfactant -- Physiological aspects, Biological transport -- Physiological aspects, Biological sciences
Abstract

There appears to be two surfactant lipid internalization pathways for uptake of liposomes by alveolar type II cells. Intact internalization of liposomes by type II cells seems to be dependent on clathedrin. Cytochalasin D decreases uptake by half, indicating a separate actin-dependent pathway. Liposome uptake appears to occur near intracellular lamellar bodies in a temperature- and energy-dependent manner.

Published
1995

15. Cluster Analysis of Neuronal Discharge Patterns During Breathing and the Laryngeal Adductor Reflex with Computer Simulations and Dynamic Visualizations

Author

Morris, Kendall F., primary, Shuman, H. Dale, additional, O'Connor, Russell, additional, Nuding, Sarah C., additional, Horton, Kofi‐Kermit, additional, Alencar, Pierina Ashley, additional, Bolser, Donald C., additional, Davenport, Paul W., additional, Gestreau, Christian, additional, Pitts, Teresa G., additional, Lindsey, Bruce G., additional, and Segers, Lauren S., additional

Published
2019
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16. Preliminary Phenotypic Cluster Analysis of Cardiorespiratory Modulated Neuronal Discharge Patterns with Dynamic Visualizations

Author

MORRIS, KENDALL F., primary, O'Connor, Russell, additional, Segers, Lauren S., additional, Nuding, Sarah C., additional, Horton, Kofi‐Kermit, additional, Alencar, P. Ashley, additional, Bolser, Donald C., additional, Dick, Thomas E., additional, Baekey, David M., additional, Lindsey, Bruce G., additional, and Shuman, H. Dale, additional

Published
2018
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22. Surface-expressed lamellar body membrane is recycled to lamellar bodies

Author

SCHALLER-BALS, S., BATES, S. R., NOTARFRANCESCO, K., TAO, J. Q., FISHER, A. B., and SHUMAN, H.

Subjects
Antibodies -- Physiological aspects, Lungs -- Cytology, Endocytosis -- Physiological aspects, Cell organelles -- Formation, Cell physiology -- Research, Biological sciences
Abstract

Schaller-Bals, S., S. R. Bates, K. Notarfrancesco, J. Q. Tao, A. B. Fisher, and H. Shuman. Surface-expressed lamellar body membrane is recycled to lamellar bodies. Am J Physiol Lung Cell Mol Physiol 279: L631-L640, 2000.--Monoclonal antibody (MAb) 3C9, an antibody generated to the lamellar body of rat lung type II pneumocytes, specifically labels the luminal face of the lamellar body membrane. To follow the retrieval of lamellar body membrane from the cell surface in these cells, MAb 3C9 was instilled into rat lungs. In vivo, it was endocytosed by type II cells but not by other lung cells. In type II cells that were isolated from rat lungs by elastase digestion and cultured on plastic for 24 h, MAb 3C9 first bound to the cell surface, then was found in endosomes, vesicular structures, and multivesicular bodies and, finally, clustered on the luminal face of lamellar body membranes. The amount internalized reached a plateau after 1.5 h of incubation and was stimulated with the secretagogue ATP. In double-labeling experiments, internalized MAb 3C9 did not completely colocalize with NBD-PC liposomes or the nonspecific endocytic marker TMA-DPH, suggesting that lamellar body membrane is retrieved back to existing lamellar bodies by a pathway different from that of bulk membrane and may be one pathway for surfactant endocytosis. The lamellar body membrane components are retrieved as subunits that are redistributed among the preexisting lamellar bodies in the cell. endocytosis; membrane trafficking; organelle biogenesis; type II pneumocytes

Published
2000

25. Patents and literature

Author

Long, M. E., Lee, C. K., Griffith, W. L., Compere, A. L., Holleman, J. W., Simonson, L. G., Lamberts, B. L., Fenton, D. M., Goldstein, J., Dawson, E. C., Roman, J. D. H., Weemen, B. K. Van, Matsumura, E., lshikawa, H., Misaki, H., Griffiths, M. W., Muir, D. D., Phillips, J. D., Gauhl, H., Schawohl, G., Seidel, H., Beaucamp, K., Johal, S., Norman, B. E., Terada, O., Aisaka, K., Teague, J. R., Huebner, A. L., Hershberger, D. F., Sternberg, M. M., Shimizu, J., Suzuki, K., Nakajima, Y., Higgins, I. J., Spence, K. D., Andrews, R. E., Peel, E., Dalton, C. C., Litchfield, J. H., Lawhon, W. T., Nakajima, H., Nagata, K., Kageyma, M., Suga, T., Suzuki, T., Motosugi, K., Sozzi, T., Schrenk, A., Buhler, M., Rosenberg, R. A., Gong, C. S., Chen, L. F., Tsao, G. T., Kurane, R., Suzuki, T., Takahara, Y., Carduck, F. J., Kloetzer, D., Veldman, G., Tolbert, W. R., Hitt, M. M., Feder, J., Kimes, R. C., Hartmeier, W., Senior, P. J., Wright, L. F., Alderson, B., Yukawa, H., Nara, T., Takayama, Y., Hayes, F. W., Weisrock, W. P., Updike, M. H., Calton, G. J., Cox, R. G., Steer, D. C., Lawford, G. R., Lewis, P. N., Whistler, R. L., Nakazawa, H., Yamane, I., Akutsu, E., Heady, R. E., Assai, Y., Shimada, M., Soda, K., Powell, K. A., Collinson, B. A., Muller, W. C., Miller, F. D., Iizuka, H., Nakamura, Y., Hung, P. P., Lee, S. G., Ptashne, M., Lauer, G. D., Roberts, T. M., Backman, K. C., Reusser, F., Manis, J. J., Highlander, K., Silhavy, T. J., Shuman, H. A., Beckwith, J., Schwartz, M., Sugano, H., Kleid, D. G., Yansura, D. G., Heyneken, H. L., and Miozzari, G. F.

Published
1983
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