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33 results on '"Shubham, Shantanu"'

6. Effects of non-invasive vagus nerve stimulation on clinical symptoms and molecular biomarkers in Parkinson’s disease

Author

Mondal, Banashree, primary, Choudhury, Supriyo, additional, Banerjee, Rebecca, additional, Roy, Akash, additional, Chatterjee, Koustav, additional, Basu, Purba, additional, Singh, Ravi, additional, Halder, Saptak, additional, Shubham, Shantanu, additional, Baker, Stuart N., additional, Baker, Mark R., additional, and Kumar, Hrishikesh, additional

Published
2024
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10. Effect of Non-Invasive Vagus Nerve Stimulation in Clinical and Molecular Biomarkers of Parkinson’s Disease

Author

Mondal, Banashree, primary, Choudhury, Supriyo, additional, Banerjee, Rebecca, additional, Roy, Akash, additional, Chatterjee, Koustav, additional, Basu, Purba, additional, Singh, Ravi, additional, Halder, Saptak, additional, Shubham, Shantanu, additional, Baker, Stuart N, additional, Baker, Mark R, additional, and Kumar, Hrishikesh, additional

Published
2023
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13. Agitated saline contrast to delineate central venous catheter position in neonates

Author

Upadhyay, Jaya, Basu, Sriparna, Srivastava, Yash, Digal, Kanhu Charan, Shubham, Shantanu, Grover, Rajat, and Singh, Poonam

Abstract

Objective: Central venous catheter (CVC) insertion is required for the management of sick neonates. Ultrasonography/targeted neonatal echocardiography (TNE) with/without normal saline (NS) flush is used to identify CVC position. The present study compared the visibility and safety of agitated saline (AS) with normal saline (NS) flush. Study design: This prospective interventional study included 110 CVC insertions, both umbilical venous catheterization (UVC) and peripherally inserted central catheterization (PICC). Catheter position was monitored by real-time TNE. Results: Overall visibility of catheter tip (combined UVC and PICC) was significantly better in AS (n= 55) compared with NS group (n= 55) [48/55 (87.2%) vs. 28/55 (50.9%); p< 0.0001]. Time to detect catheter tip by AS push was significantly less than that of NS push. There was no difference in the amount of saline flush required with either method. No major adverse effect was observed. Conclusions: AS push can be used as a safe method to delineate CVC position in neonates.

Published
2024
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17. Neuroimaging Pearls from the MDS Congress Video Challenge. Part 2: Acquired Disorders

Author

Fearon, Conor, primary, Rawal, Sapna, additional, Olszewska, Diana, additional, Alcaide‐Leon, Paula, additional, Kern, Drew S., additional, Sharma, Soumya, additional, Jaiswal, Shyam K., additional, Murthy, Jagarlapudi M.K., additional, Ha, Ainhi D., additional, Schwartz, Raymond S., additional, Fung, Victor S.C., additional, Spears, Chauncey, additional, Tholanikunnel, Tracy, additional, Almeida, Leonardo, additional, Hatano, Taku, additional, Oji, Yutaka, additional, Hattori, Nobutaka, additional, Shubham, Shantanu, additional, Kumar, Hrishikesh, additional, Bhidayasiri, Roongroj, additional, Laohathai, Christopher, additional, and Lang, Anthony E., additional

Published
2022
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19. Non-invasive vagus nerve stimulation improves clinical and molecular biomarkers of Parkinson's disease in patients with freezing of gait

Author

Mondal, Banashree, Choudhury, Supriyo, Banerjee, Rebecca, Roy, Akash, Chatterjee, Koustav, Basu, Purba, Singh, Ravi, Halder, Saptak, Shubham, Shantanu, Baker, Stuart N., Baker, Mark R., and Kumar, Hrishikesh

Subjects
Parkinson's disease, Neurology. Diseases of the nervous system, RC346-429, Predictive markers, Article
Abstract

Non-invasive vagus nerve stimulation (nVNS) is an established neurostimulation therapy used in the treatment of epilepsy, migraine and cluster headache. In this randomized, double-blind, sham-controlled crossover trial we explored the role of nVNS in the treatment of gait and other motor symptoms in Parkinson’s disease (PD) patients. In a subgroup of patients, we measured selected neurotrophin levels and markers of inflammation and oxidative stress in serum, before and after the experimental intervention. Thirty-three PD patients with associated freezing of gait were randomised to either nVNS or sham. After baseline assessments, patients were instructed to deliver 6 two-minute stimulations (total 12 min/day) of the nVNS/sham device (electroCore, Inc. USA) for one month at home. Patients were then re-assessed. After a washout period of one month, the same patients were allocated to the alternate treatment arm and the same process was followed. Significant improvements in key gait parameters were observed with nVNS, including walking speed, stance time and step length, compared to sham. Similarly, overall motor function (MDS-UPDRS III) also improved significantly following nVNS stimulation. Serum Tumor Necrosis Factor (TNF)-α and glutathione levels decreased and brain-derived neurotrophic factor (BDNF) levels increased significantly (p

Published
2020

25. Abnormal Blink Reflex and Intermuscular Coherence in Writer's Cramp

Author

Choudhury, Supriyo, Singh, Ravi, Chatterjee, Payel, Trivedi, Santosh, Shubham, Shantanu, Baker, Mark R., Kumar, Hrishikesh, and Baker, Stuart N.

Subjects
theta band, focal dystonia, Neurology, pre-pulse inhibition, oscillations, Original Research, writer's cramp
Abstract

Background: Writer's cramp (WC) is a task-specific focal hand dystonia presenting with pain, stiffness and/or tremor while writing. We explored the involvement of cortical and brainstem circuits by measuring intermuscular coherence (IMC) and pre-pulse inhibition (PPI) of the blink reflex. Methods: IMC was measured in 10 healthy controls and 20 WC patients (10 with associated tremor) while they performed a precision grip task at different force levels. Blink responses were evaluated in 9 healthy controls and 10 WC patients by stimulating the right supraorbital nerve and recording surface EMG from the orbicularis oculi muscles bilaterally. PPI involved conditioning this stimulation with a prior shock to the right median nerve (100 ms interval), and measuring the reduction in the R2 component of the blink reflex. Results: Significant IMC at 3–7 Hz was present in WC patients, but not in healthy controls. Compared to healthy controls, in WC patients the R2 component of the blink reflex showed significantly less PPI. IMC at 3–7 Hz could reliably discriminate WC patients from healthy controls. Conclusion: Cortical or sub-cortical circuits generating theta (3–7 Hz) oscillations might play an important role in the pathogenesis of WC. Moreover, the lack of PPI implicates abnormalities in brainstem inhibition in the emergence of WC. IMC may merit further development as an electrodiagnostic test for focal dystonia.

Published
2018

28. VEGF alleviates ALS-CSF induced cytoplasmic accumulations of TDP-43 and FUS/TLS in NSC-34 cells

Author

Shubham Shantanu, K. Vijayalakshmi, Trichur R. Raju, S. Shruthi, Talakad N. Sathyaprabha, Phalguni Anand Alladi, Atchayaram Nalini, and B K Chandrasekhar Sagar

Subjects
0301 basic medicine, Adult, Male, Vascular Endothelial Growth Factor A, Cytoplasm, Biology, Neuroprotection, Cell Line, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Stress granule, medicine, Humans, Amyotrophic lateral sclerosis, Amyotrophic Lateral Sclerosis, Middle Aged, medicine.disease, Cell biology, Vascular endothelial growth factor, DNA-Binding Proteins, 030104 developmental biology, chemistry, Apoptosis, Cell culture, RNA-Binding Protein FUS, Female, 030217 neurology & neurosurgery, Biomarkers
Abstract

Cytoplasmic mislocalisation and aggregation of TDP-43 and FUS/TLS proteins in spinal motor neurons contribute to the pathogenesis of the highly fatal disorder amyotrophic lateral sclerosis (ALS). We investigated the neuroprotective effect of VEGF on expression of these proteins in the motor neuronal cell line NSC-34 modelled to reminisce sporadic form of ALS. We studied the expression of TDP-43 and FUS/TLS proteins after exposure to ALS-CSF and following VEGF supplementation by quantitative confocal microscopy and electron microscopy. ALS-CSF caused cytoplasmic overexpression of both the proteins and stress-granule formation in the cells. These alterations were alleviated by VEGF supplementation. The related ultrastructural changes like nuclear membrane dysmorphism and p-bodies associated changes were also reversed. However the protein expression did not completely translocate to the nucleus, as some cells continued to show to cytoplasmic mislocalisation. Thus, the present findings indicate that VEGF alleviates TDP43 and FUS pathology by complimenting its role in controlling apoptosis and reversing choline acetyl transferase expression. Hence, VEGF appears to target multiple pathogenic processes in the neurodegenerative cascade of ALS.

Published
2016

29. Levosulpiride-induced Movement Disorders

Author

Choudhury, Supriyo, primary, Chatterjee, Koustav, additional, Singh, Ravi, additional, Shubham, Shantanu, additional, Trivedi, Santosh, additional, Chatterjee, Suparna, additional, and Kumar, Hrishikesh, additional

Published
2017
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32. Gait analysis in Parkinson’s disease assessing the effect of levodopa using a validated electronic walkway

Author

Mondal, Banashree, primary, Choudhury, Supriyo, additional, Banerjee, Rebecca, additional, Chatterjee, Payel, additional, Kulsum, Marium Umme, additional, Chatterjee, Sayan, additional, Chatterjee, Koustav, additional, Sen, Swagata, additional, Ghoshal, Anirban, additional, Shubham, Shantanu, additional, Naskar, Dipak, additional, Anand, Sidharth Shankar, additional, and Kumar, Hrishikesh, additional

Published
2016
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33. Clinical Characterization of Genetically Diagnosed Cases of Spinocerebellar Ataxia Type 12 from India.

Author

Choudhury, Supriyo, Chatterjee, Sayan, Chatterjee, Koustav, Banerjee, Rebecca, Humby, Jonathan, Mondal, Banashree, Anand, Sidharth S., Shubham, Shantanu, and Kumar, Hrishikesh

Subjects
SPINOCEREBELLAR ataxia, CEREBELLAR ataxia, NEUROLOGIC examination, DYSTONIA, EXTRAPYRAMIDAL disorders
Abstract

Abstract: View Supplementary Video Background: Spinocerebellar ataxia type 12 (SCA12) is a rare form of an autosomal‐dominant ataxic disorder associated with an expansion of CAG repeat length. Here, we present a large case series of patients with SCA12 and describe a wide range of typical and rare symptoms. Methods: Twenty‐one consecutive patients with genetically proven SCA12 underwent detailed neurological examination. We assessed clinical characteristics using validated rating scales for evaluating motor features in SCA. Nonmotor symptoms and quality of life were assessed using appropriate, validated scales. Correlations of CAG repeat length with both severity score and age of onset were explored. Results: The mean age of onset was 51 years, and most patients were descendants of a single, endogamous Indian community (Agarwal). Tremor was the most common initial presenting symptom (90%). Hand dystonia was present in 14 of 21 patients, and most patients in the cohort presented with gait disturbance. Neuropsychiatric manifestations were common coexisting features. The CAG repeat length was significantly correlated (r = −0.760; P = 0.0001) with early age of onset, but not with disease severity. Tremor affected the quality of life in 18 of 21 patients, because they had difficulty in handling liquids. Conclusions: Tremor was the most common, nonataxic symptom at initial presentation in patients with SCA12. Proximal upper limb tremor, typically with high amplitude and low frequency, can raise a strong diagnostic suspicion. Associated hand dystonia was a common coexisting motor feature. Various nonmotor features were also observed in several cases which require therapeutic attention. [ABSTRACT FROM AUTHOR]

Published
2018
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